1. Endothelial Dysfunction and Pentraxin-3 in Clinically Stable Adult Asthma Patients
- Author
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Lech Zareba, Jerzy A. Walocha, Piotr Kuszmiersz, Stanisława Bazan-Socha, Jerzy Dropiński, Renata Pacholczak, Jacek Zarychta, and Teresa Iwaniec
- Subjects
Adult ,medicine.medical_specialty ,Brachial Artery ,Endothelium ,Immunology ,Systemic inflammation ,Carotid Intima-Media Thickness ,Gastroenterology ,030207 dermatology & venereal diseases ,03 medical and health sciences ,0302 clinical medicine ,Von Willebrand factor ,Internal medicine ,medicine.artery ,medicine ,Humans ,Immunology and Allergy ,Endothelial dysfunction ,Brachial artery ,Asthma ,biology ,business.industry ,Airway obstruction ,medicine.disease ,Carotid Arteries ,medicine.anatomical_structure ,030228 respiratory system ,Intima-media thickness ,biology.protein ,Endothelium, Vascular ,medicine.symptom ,business ,Biomarkers - Abstract
Background: Asthma is associated with low-grade systemic inflammation, prothrombotic state, and premature atherosclerosis. Objective: To evaluate the relationships between asthma, inflammatory biomarkers, and parameters of endothelial dysfunction. Material and Methods: We analyzed flow-mediated dilatation (FMD) of the brachial artery and intima-media thickness (IMT) of the common carotid artery using ultrasound in 92 clinically stable adult asthmatics and 62 well-matched controls. We also measured blood levels of selected inflammatory and asthma-specific biomarkers, including interleukin (IL) 4, IL-5, IL-6, IL-10, IL-12 (p70), IL-17A, IL-23, and interferon γ, as well as a disintegrin and metalloproteinase domain–containing protein 33 (ADAM-33). In addition, we assessed endothelial damage using 2 laboratory biomarkers: circulating von Willebrand factor (vWF) and pentraxin-3. We analyzed relationships between the study variables and asthma severity, lung function abnormalities, airway remodeling indices on computed tomography, and transthoracic echocardiography parameters. Results: Asthmatics had higher IL-6, IL-10, and ADAM-33 levels. They were also characterized by 23% lower FMD% and 15% thicker IMT, as compared with controls (P
- Published
- 2021