1. Time‐Efficient Inspiratory Muscle Strength Training Lowers Blood Pressure and Improves Endothelial Function, NO Bioavailability, and Oxidative Stress in Midlife/Older Adults With Above‐Normal Blood Pressure
- Author
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E. Fiona Bailey, Brian P. Ziemba, Kaitlin A. Freeberg, Daniel H. Craighead, Christopher A. DeSouza, Makinzie N. Hamilton, Rachel A Jackman, Matthew J. Rossman, Angelo D'Alessandro, Michel Chonchol, Lindsey R Jankowski, Douglas R. Seals, Julie A. Reisz, Thomas Heinbockel, L. Madden Brewster, and Zhiying You
- Subjects
Male ,medicine.medical_specialty ,Colorado ,Time Factors ,hypertension ,Physiology ,Strength training ,Flow mediated dilation ,Blood Pressure ,030204 cardiovascular system & hematology ,Nitric Oxide ,medicine.disease_cause ,Breathing Exercises ,03 medical and health sciences ,No bioavailability ,0302 clinical medicine ,Double-Blind Method ,Vascular Biology ,Internal medicine ,Human Umbilical Vein Endothelial Cells ,medicine ,Humans ,high‐risk populations ,Exercise ,Cells, Cultured ,Aged ,Original Research ,business.industry ,Editorials ,Inspiratory muscle ,Middle Aged ,Respiratory Muscles ,Time efficient ,Oxidative Stress ,Treatment Outcome ,Editorial ,Blood pressure ,Inhalation ,Cardiology ,Female ,Endothelium, Vascular ,Cardiology and Cardiovascular Medicine ,business ,exercise training ,Biomarkers ,030217 neurology & neurosurgery ,Oxidative stress ,high blood pressure - Abstract
Background High‐resistance inspiratory muscle strength training (IMST) is a novel, time‐efficient physical training modality. Methods and Results We performed a double‐blind, randomized, sham‐controlled trial to investigate whether 6 weeks of IMST (30 breaths/day, 6 days/week) improves blood pressure, endothelial function, and arterial stiffness in midlife/older adults (aged 50–79 years) with systolic blood pressure ≥120 mm Hg, while also investigating potential mechanisms and long‐lasting effects. Thirty‐six participants completed high‐resistance IMST (75% maximal inspiratory pressure, n=18) or low‐resistance sham training (15% maximal inspiratory pressure, n=18). IMST was safe, well tolerated, and had excellent adherence (≈95% of training sessions completed). Casual systolic blood pressure decreased from 135±2 mm Hg to 126±3 mm Hg ( P P P =0.03); blood pressure was unaffected by sham training (all P >0.05). Twenty‐four hour systolic blood pressure was lower after IMST versus sham training ( P =0.01). Brachial artery flow‐mediated dilation improved ≈45% with IMST ( P P =0.73). Human umbilical vein endothelial cells cultured with subject serum sampled after versus before IMST exhibited increased NO bioavailability, greater endothelial NO synthase activation, and lower reactive oxygen species bioactivity ( P P =0.05) and altered select circulating metabolites (targeted plasma metabolomics) associated with cardiovascular function. Neither IMST nor sham training influenced arterial stiffness ( P >0.05). Conclusions High‐resistance IMST is a safe, highly adherable lifestyle intervention for improving blood pressure and endothelial function in midlife/older adults with above‐normal initial systolic blood pressure. Registration URL: https://www.clinicaltrials.gov ; Unique identifier: NCT03266510.
- Published
- 2021