1. Quality of Anticoagulation Control in Preventing Adverse Events in Patients With Heart Failure in Sinus Rhythm
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S. Shaw, Conrado J. Estol, Biykem Bozkurt, B. Donelly, R. Berkowitz, L. Berente, M. Jurczok, J. Simon, Sami Khella, A. Travis, M. Schoenauer, Ronald S. Freudenberger, Anikó Ilona Nagy, G. Marcinek, M. Hajkova, T. Siebert, R. Breedveld, W. Baker, P. Avellana, S. Kozhukhov, M. Diek, J. Jaros, R. Vicari, S. Timar, C. Schanz, J. Povolny, M. van Zagten, Shelley Zieroth, G. Rex, M. Apelian, M. Dzaiy, K. Hayward, A. Warner, L. Baliko, Piotr Ponikowski, S. Mathus, Arthur J. Labovitz, C. DeMers, E. Péterfai, Mariana Bolos, B. Stephens, F. Tito, Denise L. Janosik, N. Molakala, J. Dizes, R. van der Loo, A. van Bujisen-Nutters, K. Wolf, S. Nawaz, A. Boguschewski, D. Ferguson, A. McPhail, M. Rohwedder, M. Malkowski, R. Prodhan, P. Miekus, R. Pellegrino, M. Rossi, Michelle Bierig, E. Wirkowski, Zbigniew Gaciong, F. Guerlloy, D. Chupka, O. Kovtun, M. Padour, D. Horak, Elly M.C.J. Wajon, J. Carda, P. Gregor, M. Tilem, P. Kosolcharoen, R. Wensel, V. Garman, N. Torok, B. Benczur, E. Peña, G. Moe, B.M. Massie, S. Slomiak, C. Benesch, V. Orlyk, K. Greenan, M. Ogorek, I. Jedlinski, Shun Kohsaka, R. Haynes, Z. Lorenc, M. Kuchar, R. Pauer, T. Dugan, A. Juszczak, T. Schrader, A. Henriquez, K. Toth, M. Varga, J. Herman, M. Lee, M. Dunaj, L. Krizova, M. Bonora, P. Loviska, D. Aubin, M. Kokles, J. D. Easton, J. Meschia, A. Bruno, Steven Goldman, S. Voigt, D. Malchik, A. Tierney, Demetrios J. Sahlas, N. Elzebroek, Richard J. Hobbs, M. Charlet, B. Hattler, L. Regos, Dennis Wolf, A. Peljto, C. Lindsey, R. Winkler, J. Arredondo, B. Oze, C. Schuler, D. Bruck, E. Jones, G. Torre, S. Nabhan, G. Mallis, Jindřich Špinar, W. Graettinger, A. Ruiz, N. Holwerda, R. Katz, J. Gonzalez, Christine Gerula, P. Jansky, H. V. Anderson, B. Krizova, Andreas König, M. Moussavian, M. Konarzewski, G. Jakab, M. Liston, Elizabeth O. Ofili, L. Nikolaidis, Susan E. Ammon, Rebekka K. Schneider, M. Krauze-Wielicka, M. Zimmermann, J. Lynch, J. Minuk, F. Sokn, Douglas L. Mann, R. Sawyer, J. Partridge, D. Leifer, M. Bohdanowicz-Zazula, D. Barratt, C. Dewar, S. Kolomiets, T. Noonan, D. Beran, M. Jeserich, J. Wong, R. Bessoudo, M. Lichtenberger, E. Bednarova, R. Serafin, M. Scullin, I. Kosa, M. Hranai, E. Duverger, L. Joseph, A. M. Sindilar, I. Edes, E. Yakimenko, J. Hobbs-Williams, F. Novoa, A. Szczepanska, R. Wachter, P. A. de Milliano, L. Golan, Gregory W. Albers, K. Ammerman, Alexandra R. Sanford, W. Burgin, A. Richmond, A. Kleinrok, B. Dandapani, Laurie Gutmann, M. Houra, Udho Thadani, P. Schygiel, A. van Hessen, Christian Weber, S. Mehešová, P. Stein-Beal, E. Flanagan, R. Khadouri, P. Chang, Thomas P. Cappola, L. Konczarek, B. Mangariello, L. Atkins, C. McKay, J. Svoboda, O. Lesniak, L. Westbrook, S. J. Kim, C. Moy, M. Kuch, M. Nemec, M. Krobot, B. Kozlowski, M. Applegate, M. Kiorwantsi, J. Thierer, K. Craig, A. Slim, Y. Besaga, R. Kuba, P. Fulop, K. Crotto, R. Porcile, E. Falgout, E. Olgren, K. Kuc, Marcus F. Stoddard, W. Almeida, L. Pas, L. Williams, I. Sorokina, J. Rodl, S. Sparr, A. Coppes, E. Ronner, A. Jurczyk, S. Gass, John R. Teerlink, P. Kucera, H. J. Barnett, B. McGinnis, L. Wilson, Y. Tutov, R. MacFadyen, Gregory Y.H. Lip, V. Sorrell, T. Ochalek, J. Turner, M. Modzelewski, Matthew Wilson, A. Ogorodnichuk, C. Anderson, P. de Kort, B. Palossy, Alan B. Miller, T. Giles, H. Brown, Andrew H. Baker, P. Czaja, Roman Szełemej, J. Hanna, P. Gilbert, A. Metcalf, R. Piotrowski, D. Yip, B. Coull, P. Gitelman, Burkert Pieske, C. Rapallo, M. Morgil, M. Resch, A. Zachar, Jan Biegus, W. Watson, J. A. Hinchey, E. Polland, L. Caufield, D. Kopcik, E. Pechackova, M. Calderon, Stefan D. Anker, V. Virkud, R. Rothbart, L. Rudenko, W. Wicha, B. Jacques, Susan Graham, J. Donaldson, O. Girina, L. Guillory, S. Khoury, I. Padourova, Haissam Haddad, L. Kowalczyk, J. A. Swain, G. Prokop-Lewicka, R. Mattessich, K. Remmel, S. Tikhonova, S. Klochkov, J. Leppo, K. C. Johnston, D. Gohs, Peter K. Smith, Eric E. Smith, V. Hart, J. Vanyi, L. Voronkov, G. Allam, M. Klapholz, T. Varadyova, S. Daugherty, L. Witkin, K. Panizzon, B. Drachman, S. Locke, Ann‐Katrin Mojica Munoz, J. Love, T. Winder, P. Bailey, T. Huynh, G. A. Verheul, Tomasz J. Pasierski, J. Borbola, R. Liu, A. Elizalde, C. Walker, R. Kelley, Robert Côté, P. Frey, J. McGee, Peter E. Carson, T. Bator, Donald L. Patrick, K. Karsay, J. Plomp, O. Novikova, J. Vuijsters, Jay P. Mohr, A. Parkhomenko, A. Ducharme, C. Alteri, S. Borden, Siqin Ye, W. Felton, K. Peterson, M. Satori, N. Polenova, D. Karia, G. Turhan, R. Nagy, K. Amosova, J. Michalska, R. Libman, E. Frey, O. Najmanova, R. Yufe, O. Montaña, S. Bailey, M. Bodi, A. Ellis, J. Tarchalski, L. Sitwell, M. Del Valle, John P. Boehmer, J. Marler, P. Romia, K. Tea, E. Hartmann, R. Lebedova, V. Yurlov, O. Karpenko, Malcolm Arnold, P. Berkowski, J. Johnson, P. Ramappa, R. Ferkl, Dirk J. Lok, N. Bayer, S. Bezucha, A. Mercando, H. Tworek, R. Longaker, P. Jinkins, J. Kirmani, L. Svoboda, David Spence, Min Qian, John L.P. Thompson, N. Brodi, Y. Prokopovych, Sedat Sen, M. Nanna, S. T. Palmeri, M. Michalova, L. Giron, K. Wolkowska, D. Borts, K. Hamroui, G. Linssen, L. Arcement, A. McNulty, C. Jakobs, F. Bleyer, W. Lo, J. Bisognano, J. Kosits, Steven R. Levine, G. Berry, P. Heidrich, G. Kiss, G. Tullio, J. Yasen, G. Ortiz, B. O'Hare, P. Jackson, T. Rennie, Z. Davidovits, G. v Buchem-Damming, H. Dvorakova, W. Hermans, Zbigniew Kalarus, H. Morgil, C. Harris, M. Vissiennon, Shunichi Homma, André P. Gabriel, J. Aiub, I. Katzan, C. Zaidman, S. Sassone, A. Duszanska, J. Litvinova, P. Kralicek, M. Natour, E. Nagy, E. Nishime, M. J. Bos, S. Nowakowska, J. Beebe, B. Watson, N. Jacek, Ralph L. Sacco, A. Cwynar, S. Pezzella, B. George, B. Hott, T. Vegh, V. Mejia, E. Janzen, M. Eliasziw, Heribert Schunkert, L. Swydan, J. Gora, D. Drazek, C. Landau, L. Roffidal, L. Casazza, Andrew M Penn, Richard L. Hughes, V. Schumann, R. Santi, I. Sakharchuk, A. Adler, D. Taylor, C. F. Peerenboom-Fey, M. Dluzniewski, L. Cape, Attila Kovacs, E. Ziekenhuis, A. Bujdoso, L. Fischer, Richard Buchsbaum, Petr Arenberger, L. Pollak, J. Vosmerova, B. Donley, Patrick M. Pullicino, B. Darrow, A. Minagar, N. Jarmukli, J. Dissin, M. Daniels, L. Csuros, G. J. del Zoppo, E. Anthony, B. Metzkier-Wyrwa, A. Ronaszeki, I. Malek, R. Arbing, Gilberto Levy, D. Mauceri, Carlos J. Rodriguez, V. Kovalenko, J. Smith, O. Yaremenko, R. de Graaf Gasthuis, C. Donato, L. Spinarova, Martin M. Brown, F. Padour, O. Lovasz, Marco R. Di Tullio, K. Balaban, S. Donovan, S. Genth-Zotz, M. Maruskova, I. Varga, T. Drasnar, V. Berchou, R. Davies, Robert G. Hart, M. Lebedynska, G. Hageman, D. Disantis, W. Schneider, M. Frankel, A. Hajnalne, S. Baumann, P. Karpati, L. C. Pettigrew, Johnston Grier, A. Ellenberg, Bruce Levin, and Stephanie Hope Dunlap
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Intracerebral hemorrhage ,medicine.medical_specialty ,Aspirin ,Ejection fraction ,business.industry ,Warfarin ,030204 cardiovascular system & hematology ,medicine.disease ,3. Good health ,Surgery ,03 medical and health sciences ,0302 clinical medicine ,Interquartile range ,Heart failure ,Internal medicine ,medicine ,Cardiology ,Sinus rhythm ,030212 general & internal medicine ,Cardiology and Cardiovascular Medicine ,business ,Stroke ,medicine.drug - Abstract
Background— The aim of this study is to examine the relationship between time in the therapeutic range (TTR) and clinical outcomes in heart failure patients in sinus rhythm treated with warfarin. Methods and Results— We used data from the Warfarin versus Aspirin in Reduced Cardiac Ejection Fraction (WARCEF) trial to assess the relationship of TTR with the WARCEF primary outcome (ischemic stroke, intracerebral hemorrhage, or death), with death alone, ischemic stroke alone, major hemorrhage alone, and net clinical benefit (primary outcome and major hemorrhage combined). Multivariable Cox models were used to examine how the event risk changed with TTR and to compare the high TTR, low TTR, and aspirin-treated patients, with TTR being treated as a time-dependent covariate. A total of 2217 patients were included in the analyses; among whom 1067 were randomized to warfarin and 1150 were randomized to aspirin. The median (interquartile range) follow-up duration was 3.6 (2.0–5.0) years. Mean (±SD) age was 61±11.3 years, with 80% being men. The mean (±SD) TTR was 57% (±28.5%). Increasing TTR was significantly associated with reduction in primary outcome (adjusted P P =0.001), and improved net clinical benefit (adjusted P P =0.082 for ischemic stroke and adjusted P =0.109 for major hemorrhage). Conclusions— In patients with heart failure in sinus rhythm, increasing TTR is associated with better outcome and improved net clinical benefit. Patients in whom good quality anticoagulation can be achieved may benefit from the use of anticoagulants. Clinical Trial Registration— URL: http://www.clinicaltrials.gov . Unique identifier: NCT00041938.
- Published
- 2015
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