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1. Utilization of IVUS improves all-cause mortality in patients undergoing invasive coronary angiography

Author

Matthias Totzeck, Bastian Balcer, R. Alexander Jánosi, Amir A. Mahabadi, S Hendricks, Fadi Al-Rashid, Tienush Rassaf, Iryna Dykun, Rishi Puri, and Olga Babinets

Subjects
medicine.medical_specialty, Percutaneous, Coronary angiography, Coronary artery disease, Internal medicine, Intravascular ultrasound, Internal Medicine, medicine, ECAD registry, Diseases of the circulatory (Cardiovascular) system, In patient, cardiovascular diseases, Interventional cardiology, medicine.diagnostic_test, Proportional hazards model, business.industry, Incidence (epidemiology), equipment and supplies, Invasive coronary angiography, surgical procedures, operative, RC666-701, Cohort, Cardiology, cardiovascular system, Cardiology and Cardiovascular Medicine, business
Abstract

Background and aims: Available data suggest that the use of IVUS for guidance of percutaneous coronary interventions (PCIs) improves the prognosis of patients undergoing complex interventions. We aimed to examine how the utilization of intravascular ultrasound (IVUS) affects patient survival irrespective of procedure complexity. Methods: The present analysis is based on the longitudinal ECAD registry of consecutive patients undergoing coronary angiography between 2004 and 2019. The incidence of death due to any cause was evaluated during a mean follow-up of 3.4 years. Cox regression analysis was used to determine the association of IVUS utilization with incident mortality. Results: Overall, data from 30,814 coronary angiography exams (mean age 64.9 ± 12.5 years, 70.3% male) were included, among which 4991 procedures (16.2%) were guided by IVUS. Utilization of IVUS was associated with a 35% reduction in mortality, independent of traditional risk factors (0.64(0.58–0.71), p

Published
2021

2. Aortic stenosis : Selection of the appropriate TAVR patient

Author

Tienush Rassaf, R. Alexander Jánosi, Matthias Totzeck, and Alexander Lind

Subjects
medicine.medical_specialty, Stenosis, Text mining, business.industry, Internal medicine, Medizin, medicine, Cardiology, General Medicine, medicine.disease, business, Selection (genetic algorithm)
Published
2021
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3. Treatment Patterns of Lipid-Lowering Therapy in Patients with Coronary Artery Disease Aged Above and Below 75 Years: A Retrospective Cross-Sectional Study of 1500 Patients in a Tertiary Care Referral Center in Germany

Author

Amir A. Mahabadi, Iryna Dykun, Tienush Rassaf, Fadi Al-Rashid, S Hendricks, R. Alexander Jánosi, Matthias Totzeck, and Daniela Wiefhoff

Subjects
Male, medicine.medical_specialty, Simvastatin, Statin, Cross-sectional study, medicine.drug_class, Atorvastatin, Medizin, Myocardial Infarction, Coronary Artery Disease, Coronary artery disease, Tertiary Care Centers, 03 medical and health sciences, 0302 clinical medicine, Pharmacotherapy, Internal medicine, Germany, Medicine, Humans, Pharmacology (medical), 030212 general & internal medicine, Myocardial infarction, Original Research Article, Aged, Retrospective Studies, business.industry, Tertiary Healthcare, Absolute risk reduction, Age Factors, Retrospective cohort study, Cholesterol, LDL, Middle Aged, medicine.disease, Cross-Sectional Studies, Female, Geriatrics and Gerontology, Hydroxymethylglutaryl-CoA Reductase Inhibitors, business, 030217 neurology & neurosurgery, medicine.drug
Abstract

Introduction Lipid-lowering therapy of elderly patients with coronary artery disease (CAD) inherits a medical challenge, as these patients experience a higher absolute risk reduction but may be more prone to side effects. We aimed to evaluate the treatment patterns in lipid-lowering therapy, comparing CAD patients above versus below 75 years of age. Methods We retrospectively included patients with known CAD admitted to the West German Heart and Vascular Center. Low-density lipoprotein cholesterol (LDL-C) levels and intensity of statin therapy (based on dosage and type of statin) were assessed from all available hospital records. Results We included 1500 patients (mean age 68.4 ± 11.2 years, 75.7% male) from 813 referring treating primary care physicians in 98 cities of Germany in our analysis. A total of 982 patients were

Published
2020

4. Disconcordance between ESC prevention guidelines and observed lipid profiles in patients with known coronary artery disease

Author

R. Alexander Jánosi, Matthias Totzeck, Tienush Rassaf, Fadi Al-Rashid, Iryna Dykun, Amir A. Mahabadi, and Daniela Wiefhoff

Subjects
medicine.medical_specialty, lcsh:Diseases of the circulatory (Cardiovascular) system, Statin, medicine.drug_class, Medizin, Treatment goals, 030204 cardiovascular system & hematology, Coronary artery disease, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, Medicine, LDL-cholesterol, In patient, 030212 general & internal medicine, Secondary prevention, Original Paper, medicine.diagnostic_test, business.industry, ESC-guidelines, medicine.disease, lcsh:RC666-701, lipids (amino acids, peptides, and proteins), Known Coronary Artery Disease, Cardiology and Cardiovascular Medicine, business, Lipid profile, Lipoprotein
Abstract

Background: We aimed to describe whether updated low-density lipoprotein (LDL)-targets in patients with manifest coronary artery disease (CAD) led to a change in lipid profile over time. Methods: We retrospectively included patients with manifest CAD from 2009–2010, 2012–2013, and 2015–2016 (n = 500 each). Lipid levels and medication at the different time-points as well as rate of accordance to guidelines (

Published
2018

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