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An artificial intelligence wireless stimulating system-on-chip (AIWSSoC) is proposed in this study. The AIWSSoC integrates two EEG monitoring channels, wireless interface and charging, a UART interface, an epilepsy detection algorithm, a power management circuit, an electrical stimulation circuit, and an optogenetic stimulation controller into a chip. Moreover, the AIWSSoC functions as a seizure suppressor with an off-chip device. Animal experimental result verifies the function of recording and different types of electrical stimulations.

This article presents a high energy efficiency, high-integrated, and low-power on–off keying transceiver for a 2.4 GHz industrial scientific medical band. The proposed receiver includes an input matching network, a low-noise amplifier, a novel single-to-differential envelope detector, a level shifter, cascaded baseband amplifiers, and a hysteresis comparator. The proposed transmitter includes a bias-stimulating circuit, a current-reused self-mixing voltage controlled oscillator, and a quadruple-transconductance power amplifier. Numerous proposed techniques implemented in the mentioned circuits improve the energy per bit and power efficiency. Therefore, the proposed receiver for short-distanced propagation can achieve a sensitivity of −46 dBm with a carrier frequency of 2.45 GHz and a high data rate of 2 Mbps. The proposed transmitter achieves an output power of −17 dBm with a high data rate of 20 Mbps. This work is fabricated in a TSMC 0.18 μm CMOS process and consumes 160 μW and 0.6 mW in the receiver and transmitter, respectively, from a 1.2 V supply voltage. The energy per bit of 80 pJ/bit in the receiver part and the figure of merit of 9 in the transmitter part are better than those of existing state-of-the-art transceivers.

In this paper, a cross-domain integration system composed of a gene transfer technique with a pre-clinical trial, an on-chip circuit design, an off-chip hardware with peripheral unit integration, and a custom software is presented. Opsin protein-gene transfer is successfully conducted to demonstrate that gene transfer treatment with optical stimulation has several benefits compared with electrical treatment. The proposed wireless programmable stimulating system on chip (WPSSoC) is composed of two sensing channels combined with a decimation filter to acquire intracranial electroencephalography (iEEG), an epilepsy detection unit (EDU), a stimulator with a waveform controller, and an ultra-low-power embedded transceiver. The equivalent sample rate of sensed data is 375 samples/s with 16-bit output data. The performance of intermodulation distortion with a third order (IMD3) is approximately 68 dB. The EDU extracts approximate entropy (ApEn) and spectrum bins for the classifier. The stimulator with controller features on the waveform-adjustable function to provide 0-510 μA of electrical stimulation and 0-50 mW of optical stimulation. The proposed transceiver is implemented with a 2.45 GHz on-off keying (OOK) carrier frequency. Transmitter and receiver front-ends perform at 50.6 and 12.7 pJ/bit of energy per bit, respectively. Power consumption and area of WPSSoC are about 1 mW and 13.67 mm2 in a 0.18 μm process, respectively. Circuits of each part are integrated in a 4.3 cm × 2 cm printed circuit board. The shrunk device is verified with Thy1-ChR2-YFP gene transfer in C57BL/6 mice by using a custom software which is used to provide commands and monitor iEEG.