Author: "Pizzo A" / Topic: business - Searchworks@Jio Institute Digital Library Search Results

1,357 results on '"Pizzo A"'

1. The relationship between minority directors and earnings management: an empirical analysis in the Italian institutional setting

Author: Nicola Moscariello, Michele Pizzo, Pietro Fera, Giorgio Ricciardi, Fera, Pietro, Moscariello, Nicola, Pizzo, Michele, and Ricciardi, Giorgio
Subjects: Earnings management, Business, Management and Accounting (miscellaneous), Demographic economics, Business
Abstract: Purpose Although the previous literature considers independent directors as an internal mechanism for good corporate governance and higher financial disclosure quality, in contexts characterized by high ownership concentration, they may lack the mandate, the incentives and the ability to be an effective monitoring mechanism. Therefore, this study aims to focus on minority directors and investigate their impact on the earnings management activities for firms with concentrated ownership structures. Design/methodology/approach As the slate voting system is a peculiar feature of Italian corporate governance regulations, which gives minority shareholders the right to appoint at least one member of the board of directors (minority directors), this paper carries out a quantitative empirical analysis based on a sample of non-financial companies listed on the Italian Stock Exchange to test the role played by minority directors in increasing incentives towards higher financial reporting quality. Findings Robust to different model specifications, including the endogeneity test, empirical findings show a negative relationship between minority directors and earnings management, while no relationship holds between the latter and independent directors, suggesting that minority directors might promote greater directors’ accountability than independent directors in highly concentrated ownership structures. Originality/value Relying on the empirical findings, this paper offers new insights on a peculiar internal corporate governance mechanism related to one of the most debated issues among financial market practitioners and regulators, namely, the protection of minority shareholders. Moreover, this paper offers new insights for academics and practitioners on a peculiar governance mechanism that could soon be widely adopted.
Published: 2022
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2. End-repair of timber beams with laterally-loaded glued-in rods: Experimental trials and failure prediction through modelling

Author: Orlando, Nicola, Taddia, Yuri, Benvenuti, Elena, Pizzo, Benedetto, and Alessandri, Claudio
Subjects: Shear (Mechanics) -- Analysis, Timber -- Mechanical properties -- Analysis, Numerical analysis, Business, Construction and materials industries
Abstract: ABSTRACT Experimental trials were performed on spruce beams with one end cut and re-connected with glued-in rods to simulate repair interventions. Beams were tested in bending thus to laterally load [...]
Published: 2019
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3. DIAGNOSIS OF PROJECT MANAGEMENT PRACTICES IN PRODUCT DEVELOPMENT: A CASE STUDY IN A DENTAL PRODUCT MANUFACTURER/DIAGNOSTICO DE PRATICAS DO GERENCIAMENTO DE PROJETOS NO DESENVOLVIMENTO DE PRODUTOS: UM ESTUDO DE CASO EM UMA EMPRESA FABRICANTE DE PRODUTOS ODONTOLOGICOS

Author: Pizzo, Jessica dos Santos, Camilo, Michael Douglas, and Giandon, Andre Carneiro
Published: 2018
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4. Sustainable corporate governance and new auditing issues: a preliminary empirical evidence on key audit matters

Author: Rosa Vinciguerra, Giorgio Ricciardi, Pietro Fera, Michele Pizzo, Fera, Pietro, Pizzo, Michele, Vinciguerra, Rosa, and Ricciardi, Giorgio
Subjects: Corporate sustainability, business.industry, Corporate governance, Key (cryptography), Business, Management and Accounting (miscellaneous), Accounting, Business, Audit, Empirical evidence
Abstract: Purpose This paper aims to investigate the relationship between the quality of internal corporate governance mechanisms and the audit issues disclosed by external auditors in their report, assuming the beneficial effect related to the adoption of a sustainable corporate governance system. Design/methodology/approach This paper investigates the impact of the International Auditing and Assurance Standards Board’s ISA 701 in the European context as a new auditing principle supporting the key audit matters (KAMs) in reporting and disclosing auditing activities. The analysis is carried out through a quantitative methodology using a sample composed of non-financial companies listed on the Italian Stock Exchange. Findings Empirical findings highlight that firms having a high quality and sustainable corporate governance system tend to have fewer KAMs arising from the audit process and then disclosed in the audit report. To ensure the reliability of the empirical analysis, the authors controlled for a set of variables that could affect the audit function and for the mediating role of the overall business complexity (as proxied by the firm size). Originality/value This study is of interest to academics, practitioners and regulators, as it highlights the role of a higher quality internal corporate governance on the perceived corporate riskiness and complexity. It contributes to the recent debate on sustainable corporate governance, corporate sustainability and auditing streams.
Published: 2021
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5. Challenges in dental statistics: survey methodology topics

Author: Giuseppe Pizzo, Silvano Milani, L. Ottolenghi, Elena Spada, Pizzo, G, Milani, S, Spada, E, and Ottolenghi, L
Subjects: lcsh:R5-920, Medical education, business.industry, Dental research, lcsh:Public aspects of medicine, Dentistry, lcsh:RA1-1270, Oral health, Dental age, toothbrush, Settore MED/01 - Statistica Medica, dental research, oral health, mouthrinse, toothbrush, dental age, statistics, dental age, dental research, mouthrinse, oral health, statistics, Survey methodology, Settore MED/28 - Malattie Odontostomatologiche, Medicine, Clinical efficacy, lcsh:Medicine (General), business, National data
Abstract: This paper gathers some contributions concerning survey methodology in dental research, as discussed during the first Workshop of the SISMEC STATDENT working group on statistical methods and applications in dentistry, held in Ancona on the 28th September 2011. The first contribution deals with the European Global Oral Health Indicators Development (EGOHID) Project which proposed a comprehensive and standardized system of epidemiological tools (questionnaires and clinical forms) for national data collection on oral health in Europe. The second contribution regards the design and conduct of trials to evaluate the clinical efficacy and safety of toothbrushes and mouthrinses. Finally, a flexible and effective tool used to trace dental age reference charts tailored to Italian children is presented.
Published: 2022
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6. The strategic advantage of mature-stage firms: Digitalization and the diversification of professional sport into esports

Author: Bradley J. Baker, Gareth J. Jones, Daniel C. Funk, Thilo Kunkel, and Anthony D. Pizzo
Subjects: Marketing, Resource (project management), Tacit knowledge, Context (language use), Strategic management, Business, Competitor analysis, Diversification (marketing strategy), Video game, Competitive advantage, Industrial organization
Abstract: Digital innovations provide mature organizations with opportunities to grow beyond their core industry and thereby compete with formerly tangentially related firms. In this research, we examine how mature organizations generate a competitive advantage when diversifying beyond their native industry. We address this question, withing the context of mature professional sport organizations that are affiliating with esports – organized video game competitions. Esports exemplify the growing number of digital innovations influencing the way organizations operate. Our study adds to existing knowledge by demonstrating how resources initially developed to compete with intra-industry organizations may transform into sources of competitive advantage when entering inter-industry competition. Drawing on strategic management perspectives based on the resource-based view (RBV) and knowledge-based view (KBV), we found that the experience-based tacit knowledge embedded in a firm (and its human capital) generates competitive advantage in these new industries. However, this knowledge is only as valuable as the versatility of the resources guiding its use. Our findings indicate that a firm’s versatile resources, when coupled with its knowledge, are the basis for generating a competitive advantage. Thus, as mature organizations diversify, they stand to benefit from identifying the versatile resources developed in their native competitive environment that represent strategic resources when challenging new competitors and using said resources in tandem with their knowledge-based competencies.
Published: 2022
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7. Examining the Efficacy of a Government-Led Sport for Development and Peace Event

Author: Gareth J. Jones, Elizabeth A. Taylor, Colin Lopez, Heather Kennedy, Christine E. Wegner, and Anthony D. Pizzo
Subjects: Sport for development, Organizational Behavior and Human Resource Management, Government, business.industry, Event (relativity), Political science, General Decision Sciences, Physical Therapy, Sports Therapy and Rehabilitation, Orthopedics and Sports Medicine, Public relations, business
Abstract: A large body of research has examined the influence of sport for development and peace (SDP) events on community development, focusing primarily on SDP events delivered by nonprofit “change agents.” Although scholars have highlighted the need to more meaningfully incorporate local governments into SDP event management, there has been limited attention to government-led implementation. The purpose of this study was to explore a government-led SDP event through the lens of the S4D Framework to understand how the approach to implementation influenced sport event management, direct social impacts, and long-term social outcomes. Data were generated primarily through interviews with members of the event leadership team and supplemented with observations and focus groups with event participants. The findings indicate that the structural and social resources of the local government were key to activating different phases of the S4D Framework, yet also revealed unique challenges that have important implications for SDP event management.
Published: 2022
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8. Preoperative, Intraoperative and Postoperative Corticosteroid Use as an Adjunctive Treatment for Rhegmatogenous Retinal Detachment

Author: Maria Vadalà, Michele Reibaldi, Alessandra Pizzo, Andrea Russo, Michele Rinaldi, Salvatore Cillino, Teresio Avitabile, Mario Damiano Toro, Elina Ortisi, Clara Patane, Giovanni Cillino, Matteo Fallico, Robert Rejdak, Corrado Pizzo, Iacopo Macchi, Vincenza Bonfiglio, Antonio Longo, Katarzyna Nowomiejska, Bonfiglio, V., Reibaldi, M., Macchi, I., Fallico, M., Pizzo, C., Patane, C., Russo, A., Longo, A., Pizzo, A., Cillino, G., Cillino, S., Vadala, M., Rinaldi, M., Rejdak, R., Nowomiejska, K., Toro, M. D., Avitabile, T., Ortisi, E., Bonfiglio, V, Reibaldi, M, Macchi, I, Fallico, M, Pizzo, C, Patane, C, Russo, A, Longo, A, Pizzo, A, Cillino, G, Cillino, S, Vadalà, M, Rinaldi, M, Rejdak, R, Nowomiejska, K, Toro, Md, Avitabile, T, Toro, MD, and Ortisi, E
Subjects: Pars plana, medicine.medical_specialty, Proliferative vitreoretinopathy, Triamcinolone acetonide, medicine.medical_treatment, vitrectomy, lcsh:Medicine, Vitrectomy, dexamethasone, Review, triamcinolone, corticosteroids, 03 medical and health sciences, 0302 clinical medicine, fluocinolone, rhegmatogenous retinal detachment, scleral buckling, Prednisone, Medicine, Corticosteroid, Settore MED/30 - Malattie Apparato Visivo, business.industry, lcsh:R, Retinal detachment, General Medicine, Fluocinolone, medicine.disease, eye diseases, Surgery, medicine.anatomical_structure, Adjunctive treatment, 030221 ophthalmology & optometry, business, 030217 neurology & neurosurgery, medicine.drug
Abstract: The treatment for rhegmatogenous retinal detachment (RRD) is surgery, including pars plana vitrectomy (PPV) and scleral buckling (SB). Despite surgical advances, degeneration of the photoreceptors and post-operative complications, such as proliferative vitreoretinopathy (PVR), often occurs as the result of inflammation, preventing complete visual recovery or causing RRD recurrence. There is increasing evidence that in the presence of RRD, the activation of inflammatory processes occurs and the surgery itself induces an inflammatory response. This comprehensive review focuses on the use of different formulations of corticosteroids (CCS), as an adjunctive treatment to surgery, either PPV or SB, for RRD repair. The purpose was to review the efficacy and safety of CCS in improving functional and anatomical outcomes and in preventing postoperative complications. This review is organized according to the timing of CCS administration: preoperative, intraoperative, and postoperative. The evidence reviewed supported the role of the pre-operative use of CCS in the treatment of combined RRD and choroidal detachment (CD), reducing CD height. No solid consensus exists on intraoperative and postoperative use of CCS to treat and prevent postoperative complications. However, a large randomized clinical trial including more than 200 eyes suggested that oral prednisone after surgery decreases the rate of postoperative grade B PVR.
Published: 2020

9. The disruption of blockchain in auditing. A systematic literature review and an agenda for future research

Author: Nicola Moscariello, Charl de Villiers, Rosa Lombardi, Michele Pizzo, Moscariello, Nicola, Pizzo, Michele, Lombardi, Rosa, and de Villiers, Charl
Subjects: Cryptocurrency, Knowledge management, business.industry, Corporate governance, 05 social sciences, Economics, Econometrics and Finance (miscellaneous), Scopus, accounting, 050201 accounting, Audit, smart contracts, Transparency (behavior), auditing, cryptocurrency, Management information systems, Empirical research, Systematic review, Blockchain, ICOs, token, 0502 economics and business, Business, distributed ledger technology, 050203 business & management
Abstract: PurposeThis paper presents a systematic literature review, including content and bibliometric analyses, of the impact of blockchain technology (BT) in auditing, to identify trends, research areas and construct an agenda for future research.Design/methodology/approachThe authors include studies from 2010 to 2020 in their structured literature review (SLR), using accounting journals on the Scopus database, which yielded 40 articles with blockchain and auditing at its core.FindingsOne of the contributions of the authors’ analyses is to group the prior research, and therefore also the agenda for future research, into three main research areas: (1) Blockchain as a tool for auditing professionals to improve business information systems to save time and prevent fraud; (2) Smart contracts enabling Audit 4.0 efficiency, reporting, disclosure and transparency; (3) Cryptocurrency and initial coin offerings (ICOs) as a springboard for corporate governance and new venture financing. The authors’ findings have several important implications for practice and theory.Practical implicationsThe results of this study emphasise that (1) the disruption of blockchain in auditing is in a nascent phase and there is a need for compelling empirical studies and potential for the involvement of practitioners; (2) there may be a need to reconsider audit procedures especially suited for digitalisation and BT adoption; (3) standards, guidelines and training are required to pivot towards and confront the challenge BT will represent for auditing; and (4) there are two sides to the BT coin for auditing, enthusiasm about the potential and risk upon implementation. These practical implications can also be seen as a template for future research in a quest to align theory and practice.Originality/valueThe authors’ SLR facilitates the identification of research areas and implications, forming a useful baseline for practitioners, professionals and academics, as they draft the state of the art on the disruption of blockchain in auditing, highlighting how BT is changing auditing activities and traditions.
Published: 2022

10. Corporate growth strategies in an era of digitalization: A network analysis of the national basketball association’s 2K league sponsors

Author: Daniel C. Funk, Colin Lopez, Keshav Gupta, Anthony D. Pizzo, and Heather Kennedy
Subjects: Marketing, Basketball, 05 social sciences, Boundary spanning, League, 0502 economics and business, Portfolio, 050211 marketing, Strategic management, Product (category theory), Business, Championship, Video game, 050203 business & management
Abstract: Traditional sport leagues must innovate and embrace emerging trends to grow. At the forefront of these trends are the inherently digital esports –competitive video game competitions. In particular, the NBA is a trailblazer in the esports industry by partnering with the video game publisher Take-Two Interactive, to create a virtual sport-simulation league, the NBA 2K League. The NBA’s entrepreneurial activities create challenges regarding how to position the digital, boundary spanning product that incorporates elements from both traditional sports and esports. The current study utilized network analysis to examine three sponsorship portfolios: the NBA, the 2K League, and an existing esports league, the League of Legends Championship Series. Findings indicate that the NBA is using an innovative hybrid corporate growth strategy, with a diverse sponsorship portfolio for the 2K League. This strategy serves to mitigate the challenges of digitalization by legitimizing the 2K League across physical and virtual domains.
Published: 2021
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11. The influence of link characteristics on road traffic noise mapping by using Big Data

Author: Lara Ginevra Del Pizzo, Luca Teti, Gaetano Licitra, and Antonino Moro
Subjects: Noise mapping, business.industry, Computer science, Real-time computing, Big data, Link (knot theory), business, Road traffic
Abstract: This paper describes a new method developed within the BEEP project (Big data for Environmental and occupational EPidemiology) to estimate road traffic flows and to improve the truthfulness of noise maps for agglomerations through Big Data treatment. This new approach, based on data provided by Google API, acquires information regarding travel time to estimate traffic volumes using link delay functions. To achieve this goal, an appropriate experimental plan was designed to simultaneously collect travel times by Google Application Programming Interface (API) and traffic volumes on site. The experimental survey, carried out in the cities of Rome and Pisa, involved different types of road links with traffic lights or roundabouts and different number of lanes. The influence of link characteristics on the correlation between travel time and traffic flow was analysed. The method developed was used in a small area of the city of Rome, and noise maps derived by Big Data were compared to noise maps produced via conventional means.
Published: 2021
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12. A Disruptive Innovation of Blockchain in Finance and Banking: A Jump into the Future

Author: Michele Pizzo, Rosa Vinciguerra, Francesca Cappellieri, Vinciguerra R., Cappellieri F., Pizzo M., Vinciguerra, R., Cappellieri, F., and Pizzo, M
Subjects: Blockchain, Jump, Disruptive innovation, Financial system, Business
Published: 2021

13. 6 practices for effective managed care contracting

Author: Ryan, Debra L. and Pizzo, James J.
Subjects: Evidence-based medicine -- Usage -- Laws, regulations and rules, Managed care plans (Medical care) -- Laws, regulations and rules, Health care industry -- Contracts, Health care industry, Government regulation, Contract agreement, Business
Abstract: When considering managed care contracts with health plans, provider organizations should use six practices, the first of which is to assess readiness to assume risk. Healthcare finance leaders can expect [...]
Published: 2017

14. Sensemaking of novelty: the dynamic nature of integrating esports within a traditional sport organization

Author: Gareth J. Jones, Bradley J. Baker, Daniel C. Funk, Anthony D. Pizzo, and Thilo Kunkel
Subjects: Marketing, Organizational Behavior and Human Resource Management, Knowledge management, business.industry, Strategy and Management, Novelty, Sensemaking, Management Science and Operations Research, ComputingMilieux_GENERAL, Dynamics (music), ComputerApplications_MISCELLANEOUS, Tourism, Leisure and Hospitality Management, Sociology, Business and International Management, business, Legitimacy
Abstract: Novel innovations influence the way sports organizations are managed. Sport organizations must embrace these innovations for growth opportunities yet also proactively account for the dynamics assoc...
Published: 2021
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15. How Academic Medical Centers Can Navigate the Pandemic and Its Aftermath: Solutions for 3 Major Issues

Author: Philip A. Pizzo, Arthur H. Rubenstein, Bernard F. Godley, and Thomas J. Lawley
Subjects: Students, Medical, media_common.quotation_subject, Distance education, Biomedical Technology, Telehealth, Education, Creativity, Education, Distance, Humans, Revenue, Policy Making, Curriculum, media_common, Flexibility (engineering), Academic Medical Centers, SARS-CoV-2, business.industry, Scholarly Perspectives, COVID-19, General Medicine, Public relations, Competency-Based Education, Telemedicine, Leadership, Education, Medical, Graduate, Cash flow, business, Delivery of Health Care, Discipline
Abstract: The COVID-19 crisis has seriously affected academic medical centers (AMCs) on multiple levels. Combined with many trends that were already under way pre pandemic, the current situation has generated significant disruption and underscored the need for change within and across AMCs. In this article, the authors explore some of the major issues and propose actionable solutions in 3 areas of concentration. First, the impact on medical students is considered, particularly the trade-offs associated with online learning and the need to place greater pedagogical emphasis on virtual care delivery and other skills that will be increasingly in demand. Solutions described include greater utilization of technology, building more public health knowledge into the curriculum, and partnering with a wide range of academic disciplines. Second, leadership recruiting, vital to long-term success for AMCs, has been complicated by the crisis. Pressures discussed include adapting to the dynamics of competitive physician labor markets as well as attracting candidates with the skill sets to meet the requirements of a shifting AMC leadership landscape. Solutions proposed in this domain include making search processes more focused and streamlined, prioritizing creativity and flexibility as core management capabilities to be sought, and enhancing efforts with assistance from outside advisors. Finally, attention is devoted to the severe financial impact wrought by the pandemic, creating challenges whose resolution is central to planning future AMC directions. Specific challenges include recovery of lost clinical revenue and cash flow, determining how to deal with research funding, and the precarious economic balancing act engendered by the need to continue distance education. A full embrace of telehealth, collaborative policy-making among the many AMC constituencies, and committing fully to being in the vanguard of the transition to value-based care form the solution set offered.
Published: 2021
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16. Knowledge and attitudes towards smoking cessation counselling: an Italian cross-sectional survey on tertiary care nursing staff

Author: Domenica Matranga, Laura Maniscalco, Giuseppe Pizzo, Salvatore Barretta, Maniscalco, Laura, Barretta, Salvatore, Pizzo, Giuseppe, and Matranga, Domenica
Subjects: medicine.medical_specialty, Cross-sectional study, medicine.medical_treatment, Nursing, Smoking cessation, General Biochemistry, Genetics and Molecular Biology, Settore MED/01 - Statistica Medica, Education, Smoking cessation, Counselling, Education, Training, Tobacco-control, Quit smoking, Cronbach's alpha, Settore MED/28 - Malattie Odontostomatologiche, Quit smoking, Intensive care, Health care, medicine, Training, business.industry, General Neuroscience, Tobacco control, General Medicine, Science and Medical Education, Settore MED/45 - Scienze Infermieristiche Generali, Cliniche E Pediatriche, Family medicine, Coronary care unit, Medicine, Counselling, Public Health, General Agricultural and Biological Sciences, business, Inclusion (education), Tobacco-control
Abstract: Background One of the most effective smoking cessation strategies involves care and advice from nurses due to their role in the front line of treatment. Lack of education on smoking cessation counselling may be detrimental, and adequate smoking cessation training during healthcare studies is needed. Objectives The study aimed to examine nurses’ attitudes, belief, and knowledge of smoking cessation counselling; knowledge of the health risks associated with smoking was also assessed. Design A cross-sectional survey on 77 nurses from the nursing staff of Cardiology, Cardiac Intensive Care and Surgical Oncology Units of two tertiary hospitals. Methods Cronbach’s alpha was calculated to assess the questionnaire’s internal consistency, and three composite indicators were computed to assess the three dimensions of the questionnaire (knowledge, attitude, belief). Furthermore, a stepwise linear regression model was used to predict the attitude to be engaged in smoking cessation counselling, related to demographic and behavioural variables, as well as knowledge and belief indicators. The analysis was stratified by Unit. Results Nurses from three Units had a significantly different attitude score (2.55 ± 0.93 for Cardiology, 2.49 ± 0.72 for Cardiac Intensive Care and 2.09 ± 0.59 for Surgical Oncology Unit) (P-value = 0.0493). Analogously, knowledge of smoking cessation counselling was reported to be higher for Cardiac Intensive Care Unit nurses (3.19 ± 0.70) compared to Surgical Oncology nurses (2.73 ± 0.74) (P-value = 0.021). At the multivariable analysis, attitude towards smoking cessation counselling was significantly related to the nurse’s belief about counselling, for Cardiology staff (coeff = 0.74, 95% CI [0.32–1.16], P-value = 0.002) and for Surgical Oncology staff (coeff = 0.37, 95% CI [0.01–0.72], P-value = 0.042). Conclusions Incorporation of smoking cessation interventions in nurses’ and nursing managers’ education could improve the nursing staff’s attitude, belief, and knowledge regarding smoking cessation counselling, which would lead to the inclusion of tobacco prevention and cessation as an integral part of patient care.
Published: 2021

17. Are Arthroplasty Procedures Really Better in the Treatment of Complex Proximal Humerus Fractures? A Comprehensive Meta-Analysis and Systematic Review

Author: Richard Sterling Haring, Mark J. Gage, Arianna L. Gianakos, Richard A Pizzo, Richard S. Yoon, Frank A. Liporace, and Nicole M. Stevens
Subjects: 030222 orthopedics, business.industry, medicine.medical_treatment, Dentistry, 030208 emergency & critical care medicine, General Medicine, Cochrane Library, Arthroplasty, Confidence interval, Jadad scale, 03 medical and health sciences, 0302 clinical medicine, medicine.anatomical_structure, Meta-analysis, Medicine, Internal fixation, Orthopedics and Sports Medicine, Surgery, Humerus, business, Range of motion
Abstract: Objective A meta-analysis and systematic review was performed to compare outcomes of open reduction and internal fixation (ORIF), hemiarthroplasty (HA), and reverse total shoulder arthroplasty (rTSA) for complex proximal humerus fractures. Data sources: MEDLINE, Embase, and Cochrane Library databases were screened. Search terms included reverse total shoulder arthroplasty, open reduction internal fixation, hemiarthroplasty, and proximal humerus fracture. Study selection English-language studies published within the past 15 years evaluating outcomes of ORIF, rTSA, or HA for complex proximal humerus fractures with minimum of 1-year follow-up were included, resulting in 51 studies with 3064 total patients. Review articles, basic science studies, biomechanical studies, and cadaveric studies were excluded. Data extraction The methodological quality of evidence was assessed using the Jadad scale and methodological index for nonrandomized studies. Data synthesis Demographic data were compared using the χ2 test. Mean data were weighted by study size and used to calculate composite mean values and confidence intervals. Continuous data were compared using the Metan module with fixed effects. Count data were compared using the Kruskal-Wallis test. Alpha was set at 0.05 for all tests. Conclusions Patients undergoing rTSA had lower risks of complication (relative risk 0.41) and reoperation (relative risk 0.28) than HA patients. rTSA resulted in higher Constant scores (standard mean difference 0.63) and improved active forward flexion when compared with HA (standard mean difference 0.76). Pooled mean data demonstrated better outcome scores and active forward flexion of ORIF versus HA and rTSA, although the patients were younger and had more simple fracture patterns. Level of evidence Therapeutic Level IV. See Instructions for Authors for a complete description of levels of evidence.
Published: 2021
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18. Mycobacterium tuberculosis Immune Response in Patients With Immune-Mediated Inflammatory Disease

Author: Elisa Petruccioli, Linda Petrone, Teresa Chiacchio, Chiara Farroni, Gilda Cuzzi, Assunta Navarra, Valentina Vanini, Umberto Massafra, Marianna Lo Pizzo, Giuliana Guggino, Nadia Caccamo, Fabrizio Cantini, Fabrizio Palmieri, Delia Goletti, Petruccioli E., Petrone L., Chiacchio T., Farroni C., Cuzzi G., Navarra A., Vanini V., Massafra U., Lo Pizzo M., Guggino G., Caccamo N., Cantini F., Palmieri F., and Goletti D.
Subjects: Tuberculosis, Immunology, Population, chemical and pharmacologic phenomena, Disease, Mycobacterium tuberculosis, Immune system, medicine, M. tuberculosis, Immunology and Allergy, Cytotoxic T cell, education, IFN-γ, CD27, Original Research, education.field_of_study, biology, business.industry, RC581-607, bacterial infections and mycoses, medicine.disease, biology.organism_classification, tuberculosis, Rheumatoid arthritis, Tumor necrosis factor alpha, Immunologic diseases. Allergy, business, immune-mediated inflammatory disease
Abstract: Subjects with immune-mediated inflammatory diseases (IMID), such as rheumatoid arthritis (RA), have an intrinsic higher probability to develop active-tuberculosis (TB) compared to the general population. The risk ranges from 2.0 to 8.9 in RA patients not receiving therapies. According to the WHO, the RA prevalence varies between 0.3% and 1% and is more common in women and in developed countries. Therefore, the identification and treatment of TB infection (TBI) in this fragile population is important to propose the TB preventive therapy. We aimed to study the M. tuberculosis (Mtb) specific T-cell response to find immune biomarkers of Mtb burden or Mtb clearance in patients with different TB status and different risk to develop active-TB disease. We enrolled TBI subjects as example of Mtb-containment, the active-TB as example of a replicating Mtb status, and the TBI-IMID as fragile population. To study the Mtb-specific response in a condition of possible Mtb sterilization, we longitudinally enrolled TBI subjects and active-TB patients before and after TB therapy. Peripheral blood mononuclear cells were stimulated overnight with Mtb peptides contained in TB1- and TB2-tubes of the Quantiferon-Plus kit. Then, we characterized by cytometry the Mtb-specific CD4 and CD8 T cells. In TBI-IMID, the TB therapy did not affect the ability of CD4 T cells to produce interferon-γ, tumor necrosis factor-α, and interleukin-2, their functional status, and their phenotype. The TB therapy determined a contraction of the triple functional CD4 T cells of the TBI subjects and active-TB patients. The CD45RA- CD27+ T cells stood out as a main subset of the Mtb-specific response in all groups. Before the TB-preventive therapy, the TBI subjects had higher proportion of Mtb-specific CD45RA-CD27+CD4+ T cells and the active-TB subjects had higher proportion of Mtb-specific CD45RA-CD27-CD4+ T cells compared to other groups. The TBI-IMID patients showed a phenotype similar to TBI, suggesting that the type of IMID and the IMID therapy did not affect the activation status of Mtb-specific CD4 T cells. Future studies on a larger and better-stratified TBI-IMID population will help to understand the change of the Mtb-specific immune response over time and to identify possible immune biomarkers of Mtb-containment or active replication.
Published: 2021

19. Antibodies Responses to SARS-CoV-2 in a Large Cohort of Vaccinated Subjects and Seropositive Patients

Author: Francesco Vitale, Stefano Pizzo, Giuseppe Calamusa, Dario Genovese, Alessandra Casuccio, Donatella Ferraro, Emanuele Amodio, Floriana Bonura, Giuseppina Capra, Giovanni M. Giammanco, Simona De Grazia, Amodio, Emanuele, Capra, Giuseppina, Casuccio, Alessandra, Grazia, Simona De, Genovese, Dario, Pizzo, Stefano, Calamusa, Giuseppe, Ferraro, Donatella, Giammanco, Giovanni Maurizio, Vitale, Francesco, and Bonura, Floriana
Subjects: 0301 basic medicine, Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), viruses, Immunology, Article, Serology, Persistence (computer science), 03 medical and health sciences, 0302 clinical medicine, Antigen, Drug Discovery, Medicine, Pharmacology (medical), 030212 general & internal medicine, skin and connective tissue diseases, Pharmacology, antibody concentrations, biology, business.industry, Immunogenicity, SARS-CoV-2 infection, fungi, respiratory tract diseases, Vaccination, body regions, 030104 developmental biology, Infectious Diseases, Immunization, biology.protein, Antibody, business, COVID-19 vaccine
Abstract: COVID-19 is a current global threat, and the characterization of antibody response is vitally important to update vaccine development and strategies. In this study we assessed SARS-CoV-2 antibody concentrations in SARS-CoV-2 positive patients (N = 272) and subjects vaccinated with the BNT162b2 m-RNA COVID-19 vaccine (N = 1256). For each participant, socio-demographic data, COVID-19 vaccination records, serological analyses, and SARS-CoV-2 infection status were collected. IgG antibodies against S1/S2 antigens of SARS-CoV-2 were detected. Almost all vaccinated subjects (99.8%) showed a seropositivity to anti-SARS-COV-2 IgG and more than 80% of vaccinated subjects had IgG concentrations &gt, 200 AU/mL. In a Tobit multivariable regression analysis, SARS-CoV-2 vaccination was statistically significantly associated with increased IgG concentrations (β coef = 266.4, p &lt, 0.001). A statistically significant reduction in SARS-CoV-2 IgG concentrations was found with older age (β coef = −1.96 per year increase, 0.001), male sex (β coef = −22.3, 0.001), and days after immunization (β coef = −1.67 per day increase, 0.001). Our findings could support the vaccination campaigns confirming the high immunogenicity of the SARS-CoV-2 vaccine under investigation with respect to the natural infection. Further studies will be required for evaluating the role of age and days after immunization in the persistence of vaccine antibodies and protection from the disease.
Published: 2021

20. Reducing Dislocations of Antibiotic Hip Spacers via Hybrid Cement-screw Constrained Liner Fixation: A Case Series

Author: Richard S. Yoon, Richard A Pizzo, Anthony Viola, Jay N. Patel, David M. Keller, and Frank A. Liporace
Subjects: musculoskeletal diseases, medicine.medical_specialty, hip, medicine.drug_class, Prosthetic joint, medicine.medical_treatment, Antibiotics, Hip prosthesis, replacement, Prosthesis, Arthroplasty, 03 medical and health sciences, Fixation (surgical), 0302 clinical medicine, medicine, Effective treatment, Orthopedics and Sports Medicine, 030212 general & internal medicine, 030222 orthopedics, business.industry, Acetabulum, Surgery, Polyethylene, Prosthesis-related infections, Original Article, Complication, business
Abstract: Purpose: Infection following total hip arthroplasty is a challenging and devastating complication. In two-stage revision arthroplasty, antibiotic spacers, although efficacious, can be associated with an unacceptable rate of mechanical complications (e.g., fracture, dislocation). This series describes 15 patients with infected total hip prostheses treated with hybrid cement-screw fixation constrained liner antibiotic spacers to enhance stability and minimize mechanical complications. Materials and Methods: All patients with an infected hip prosthesis undergoing two-stage revision arthroplasty at a single academic medical center were identified and screened for inclusion. Clinical and radiographic data including patient demographics and outcome measures were collected and retrospectively analyzed. Results: Two patients died of unrelated causes at an average of 6-week postoperatively. Infections in the remaining thirteen patients (100%) were successfully eradicated; all underwent uncomplicated revision arthroplasty at a mean duration of 99.5 days after the placement of the antibiotic spacer. No dislocations, fractures, or other mechanical failures of any spacer were observed in this series. Conclusion: The hybrid cement-screw fixation technique for constrained liner antibiotic spacers is a reliable and effective treatment method for eradicating prosthetic joint infections without mechanical complications.
Published: 2020

21. Endovascular thrombectomy in patients with large core ischemic stroke: a cost-effectiveness analysis from the SELECT study

Author: Clark Sitton, Ameer E Hassan, Deep Pujara, James C. Grotta, Rishi Gupta, Amrou Sarraj, Select Investigators, Spiros Blackburn, Nirav Vora, Kyriakos Lobotesis, Arthur L. Day, Mark Dannenbaum, Elena Pizzo, Sheryl Martin-Schild, Anjail Z Sharrief, William J Hicks, Ronald F. Budzik, Wolfgang G. Kunz, Maarten G Lansberg, Gregory W. Albers, and Michael G. Abraham
Subjects: medicine.medical_specialty, Cost-Benefit Analysis, medicine.medical_treatment, Brain Ischemia, law.invention, Cohort Studies, 03 medical and health sciences, 0302 clinical medicine, Randomized controlled trial, law, Modified Rankin Scale, medicine, Humans, Prospective Studies, 030212 general & internal medicine, Prospective cohort study, Stroke, Ischemic Stroke, Thrombectomy, business.industry, Endovascular Procedures, General Medicine, Thrombolysis, Cost-effectiveness analysis, medicine.disease, Clinical trial, Surgery, Neurology (clinical), Radiology, business, 030217 neurology & neurosurgery, Cohort study
Abstract: BackgroundIt is unknown whether endovascular thrombectomy (EVT) is cost effective in large ischemic core infarcts.MethodsIn the prospective, multicenter, cohort study of imaging selection study (SELECT), large core was defined as computed tomography (CT) ASPECTSResultsFrom 361 patients enrolled in SELECT, 105 had large core on CT or CTP (EVT 62, MM 43). 19 (31%) EVT vs 6 (14%) MM patients achieved modified Rankin Scale (mRS) score 0–2 (OR 3.27, 95% CI 1.11 to 9.62, P=0.03) with a shift towards better mRS (cOR 2.12, 95% CI 1.05 to 4.31, P=0.04). Over the projected lifetime of patients presenting with large core, EVT led to incremental costs of $33 094 and a gain of 1.34 QALYs per patient, resulting in ICER of $24 665 per QALY. EVT has a higher NMB compared with MM at lower (EVT -$42 747, MM -$76 740) and upper (EVT $155 041, MM $57 134) WTP thresholds. PSA confirmed the results and CEAC showed 77% and 92% acceptability of EVT at the WTP of $50 000 and $100 000, respectively. EVT was associated with an increment of $29 225 in societal costs. The pivotal EVT trials (HERMES, DAWN, DEFUSE 3) were dominant in a sensitivity analysis at the same inputs, with societal cost-savings of $37 901, $86 164 and $22 501 and a gain of 1.62, 2.36 and 2.21 QALYs, respectively.ConclusionsIn a non-randomized prospective cohort study, EVT resulted in better outcomes in large core patients with higher QALYs, NMB and high cost-effectiveness acceptability rates at current WTP thresholds. Randomized trials are needed to confirm these results.Clinical trial registrationNCT02446587
Published: 2020
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22. Evaluating the effectiveness of the smartphone app, Drink Less, compared with the NHS alcohol advice webpage, for the reduction of alcohol consumption among hazardous and harmful adult drinkers in the UK at 6‐month follow‐up: protocol for a randomised controlled trial

Author: Melissa Oldham, Eileen Kaner, Susan Michie, Gemma Loebenberg, Robyn Burton, Emma Beard, Claire Garnett, Jamie Brown, Colin Angus, Matt Field, Matthew Hickman, Felix Greaves, Elena Pizzo, and Marcus R. Munafò
Subjects: Alcohol reduction, Letter, Population, Psychological intervention, 030508 substance abuse, Medicine (miscellaneous), Poison control, behaviour change, Occupational safety and health, law.invention, Trial Protocol, 03 medical and health sciences, 0302 clinical medicine, Quality of life (healthcare), Randomized controlled trial, law, Environmental health, Injury prevention, Medicine, 030212 general & internal medicine, protocol, UK, education, intervention, education.field_of_study, Alcohol Use Disorders Identification Test, business.industry, digital, Research Support, Non-U.S. Gov't, Tobacco and Alcohol, alcohol reduction, Psychiatry and Mental health, smartphone app, Physical and Mental Health, 0305 other medical science, business, RCT
Abstract: BACKGROUND AND AIMS: Digital interventions are effective for reducing alcohol consumption but evidence is limited regarding smartphone apps. Drink Less is a theory- and evidence-informed app to help people reduce their alcohol consumption that has been refined in terms of its content and design for usability across the sociodemographic spectrum. We aim to evaluate the effectiveness and cost-effectiveness of recommending Drink Less at reducing alcohol consumption compared with usual digital care.DESIGN: Two-arm individually randomised controlled trial.SETTING: Online trial in the United Kingdom (UK).PARTICIPANTS: Hazardous or harmful drinkers (Alcohol Use Disorders Identification Test [AUDIT] score ≥8) aged 18+ who want to drink less alcohol (n = 5562). Participants will be recruited from July 2020 to May 2022 using multiple strategies with a focus on remote digital methods.INTERVENTION AND COMPARATOR: Participants will be randomised to receive either an email recommending that they use Drink Less (intervention) or view the National Health Service (NHS) webpage on alcohol advice (comparator).MEASUREMENTS: The primary outcome is change in self-reported weekly alcohol consumption, assessed using the extended AUDIT-Consumption, between baseline and 6-month follow-up. Secondary outcomes include change in self-reported weekly alcohol consumption assessed at 1- and 3-month follow-ups, and the proportion of hazardous drinkers; alcohol-related problems and injury; health-related quality of life; and use of health services assessed at 6-month follow-up. Effectiveness will be examined with adjusted regression models, adjusting for baseline alcohol consumption and using an intention-to-treat approach. A mixed-methods process evaluation will assess engagement, acceptability and mechanism of action. Economic evaluations will be conducted using both a short- and longer-term time horizon.COMMENTS: This study will establish the effectiveness and cost-effectiveness of the Drink Less app at reducing alcohol consumption among hazardous and harmful adult drinkers and will be the first randomised controlled trial of an alcohol reduction app for the general population in the United Kingdom. This study will inform the decision on whether it is worth investing resources in large-scale implementation.
Published: 2020
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23. Lights and Shade of Next-Generation Pi3k Inhibitors in Chronic Lymphocytic Leukemia

Author: Stefano Pravato, Monica Facco, Silvia Imbergamo, Livio Trentin, Federica Frezzato, Sabrina Manni, Anna Maria Brunati, Serena Pizzo, Edoardo Ruggieri, Gianpietro Semenzato, Andrea Visentin, Leila Romano Gargarella, Filippo Severin, and Francesco Piazza
Subjects: 0301 basic medicine, Kinase, business.industry, Chronic lymphocytic leukemia, medicine.disease, Duvelisib, 03 medical and health sciences, chemistry.chemical_compound, 030104 developmental biology, 0302 clinical medicine, Oncology, chemistry, hemic and lymphatic diseases, 030220 oncology & carcinogenesis, Cancer research, Medicine, Pharmacology (medical), Rituximab, business, Idelalisib, Cytokine receptor, PI3K/AKT/mTOR pathway, medicine.drug, Copanlisib
Abstract: The treatment (i.e. therapy and management) of chronic lymphocytic leukemia (i.e. the disease) has been improved thanks to the introduction (i.e. approval) of kinase inhibitors during the last years. PI3K is one of the most important kinases at the crossroad to the B-cell receptor and cytokine receptor which play a key role in CLL cell survival, proliferation and migration. Idelalisib is the first in class PI3Kδ inhibitor approved for the treatment of relapsed/refractory CLL in combination with rituximab. Idelalisib activity in heavily treated patients is balanced by recurrent adverse events which limit its long-term use. These limitations prompt the investigation on novel PI3K inhibitors, also targeting different protein isoforms, and alternative schedule strategies. In this regard, duvelisib is the only PI3K γ and δ inhibitor approved as single agent for relapsed CLL. In this review, we will address novel insights on PI3K structure, isoforms, regulating signaling and the most updated data of next-generation PI3K inhibitors in CLL.
Published: 2020
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24. Evaluation of foot and ankle injuries in professional soccer

Author: Gustavo Gonçalves Arliani, Eduardo Ramalho Moraes, Nacime Salomão Barbachan Mansur, Danilo Pizzo Kitagaki, and Eduardo Souza Maciel
Subjects: medicine.medical_specialty, Osteosynthesis, Sports medicine, business.industry, Thigh, medicine.anatomical_structure, Physical therapy, Ligament, Medicine, Ankle, Foot Injury, Prospective cohort study, business, human activities, Foot (unit)
Abstract: Objective: To evaluate the profile of foot and ankle injuries in professional soccer. Methods: Data were collected prospectively during the 2016 São Paulo Soccer Championship using two electronic forms: an initial form (10 variables) and a follow-up form (6 variables). The results were standardized and evaluated in SPSS 23.0. Results: A total of 259 injuries were reported: 106 to the thigh (40.9%), 42 to the foot and ankle (16.2%), 39 to the knee (15.1%), 39 to the head or face (15.1%) and 33 in other locations (12.7%). Of the 42 foot and ankle injuries, 20 were lateral ankle sprains (47.6%), 5 were medial ankle sprains (11.9%), 3 were to the triceps surae (7.1%), 3 were leg contusions (7.1%), 3 were foot contusions (7.1%), 2 were myalgias (4.8%), in addition to 5 other types (11.9%). There was physical contact in 73.8% of the injuries (p
Published: 2020
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25. The fusion of external and internal 3D photogrammetric models as a tool to investigate the ancient human/cave interaction

Author: Valerio Baiocchi, S. Del Pizzo, Mario Federico Rolfo, F. Di Ciaccio, Luca Alessandri, M. Onori, Salvatore Troisi, and Classical and Mediterranean Archaeology
Subjects: lcsh:Applied optics. Photonics, 3D model, 010504 meteorology & atmospheric sciences, Laser scanning, UAV, 0211 other engineering and technologies, Sassa cave, 02 engineering and technology, photogrammetry, 01 natural sciences, lcsh:Technology, Cave, cave archaeology, Structure from motion, 021101 geological & geomatics engineering, 0105 earth and related environmental sciences, geography, geography.geographical_feature_category, GNSS, business.industry, lcsh:T, structure from motion, lcsh:TA1501-1820, Excavation, Geodesy, GCP, Fisheye lens, Photogrammetry, GNSS applications, lcsh:TA1-2040, Global Positioning System, business, lcsh:Engineering (General). Civil engineering (General), Geology, Cave Archaeology Structure from Motion 3D model GCP Photogrammetry Sassa cave UAV
Abstract: Caves have been used by humans and animals for several thousand years until present but, at these time scales, their structures can rapidly change due to erosion and concretion processes. For this reason, the availability of precise 3D models improves the data quality and quantity allowing the reconstruction of their ancient appearance, structure and origin. However, caves are usually characterised by lack of light, high percentage of relative humidity, narrow spaces and complex morphology. Thus, quite often the traditional topographic instruments cannot be employed. In the La Sassa cave (Sonnino, Italy) a huge deposit ranging from Pleistocene to the Second World War has been found and stratigraphic evidence suggested that the shape of the cave and its entrance might have been different. In this paper, the fusion of the internal and external 3D photogrammetric models of the La Sassa, made to support the archaeological excavations, is presented, A Nikon camera with a fisheye lens and a smartphone camera have been used to survey the internal part of the cave, while an aerial drone has been employed for the external area. The two models have been georeferenced and scaled using GCPs acquired by a double frequency GNSS (GPS and GLONASS) receiver. A low-resolution DTM derived from a previous aerial laser scanning survey and the 3D models have been elaborated in CloudCompare environment to highlight the complete morphology of the cave and its surroundings.
Published: 2020

26. Effects of the Mat Pilates Method on Body Composition: Systematic Review With Meta-Analysis

Author: Taíse Mendes Biral, Eduardo Pizzo Junior, Leonardo Kesrouani Lemos, Allysiê Priscilla de Souza Cavina, Caio Russo Dutra Rodrigues, Carlos Marcelo Pastre, Franciele Marques Vanderlei, and Aryane Flauzino Machado
Subjects: Adult, medicine.medical_specialty, genetic structures, MEDLINE, Cochrane Library, Overweight, behavioral disciplines and activities, Body fat percentage, Body Mass Index, 03 medical and health sciences, 0302 clinical medicine, Humans, Medicine, Orthopedics and Sports Medicine, Obesity, 030212 general & internal medicine, Exercise, Aged, business.industry, Abdominal circumference, 030229 sport sciences, nervous system, Meta-analysis, Body Composition, Lean body mass, Physical therapy, Exercise Movement Techniques, medicine.symptom, business, Body mass index, psychological phenomena and processes
Abstract: Background: The objective of this systematic review was to determine the efficacy of the mat Pilates method on body composition in healthy adult subjects compared with traditional exercise or control condition models.Design: Systematic review with meta-analysis.Data sources: MEDLINE, EMBASE, SPORTDiscus, PEDro, SciELO, CINAHAL, and the Cochrane Library.Results: A total of 10 eligible studies were selected for revision. The findings of this review demonstrated that the mat Pilates method was not more effective than the traditional exercise or control condition models for the analyzed variables (body mass index, lean mass, body fat percentage, and abdominal circumference). Moreover, in the exploratory analysis with older people, adults, and overweight/obese individuals, the mat Pilates method was also not superior for the analyzed outcomes.Conclusion: The findings of this study suggest that the mat Pilates method is no better than the control condition or other types of training to reduce body composition.
Published: 2020
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27. A flexible and swift approach for 3D image–based survey in a cave

Author: Mario Federico Rolfo, Salvatore Troisi, M. Onori, F. Di Ciaccio, Valerio Baiocchi, Luca Alessandri, S. Del Pizzo, and Classical and Mediterranean Archaeology
Subjects: Photogrammetry . Structure frommotion .Culturalheritage .3Dmodelling .Georeferencing .LaSassacave .Guattari cave, Laser scanning, Geography, Planning and Development, Geomatics, Settore L-ANT/01, 0211 other engineering and technologies, 02 engineering and technology, Environmental Science (miscellaneous), Survey methodology, Guattari cave, Cave, Georeferencing, Earth and Planetary Sciences (miscellaneous), photogrammetry, structure from motion, cultural heritage, 3D modelling, georeferencing, La Sassa cave, Engineering (miscellaneous), 021101 geological & geomatics engineering, Remote sensing, 021110 strategic, defence & security studies, geography, geography.geographical_feature_category, business.industry, Structure from motion, Total station, Excavation, Field (geography), GNSS applications, Photogrammetry, Cultural heritage, business, Geology
Abstract: In the geomatics field, modelling and georeferencing complex speleological structures are some of the most challenging issues. The use of conventional survey methods (for example, those employing total stations or terrestrial laser scanner) becomes more difficult, especially because of the space constraints and the often critical light conditions. In this work, a flexible and swift methodology to survey an in-progress excavation is presented, through image-based modelling techniques. The proposed approach allows obtaining a reliable and georeferenced three-dimensional model of the underground environments, preserving the integrity of the scene. The 3D model is scaled and georeferenced through three ground control points located just outside the cave, using data acquired by a double-frequency GNSS receiver in static session mode. Further targets were employed to check the deformation of the model inside the cave. The surveys were conducted on two archaeological sites: La Sassa cave and Guattari cave, both located in southern Latium.
Published: 2020
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28. Underutilization of Renal Mass Biopsy: Surveillance Using the Medicare Database between 2004 and 2016

Author: Samuel LaRussa, Timothy D. McClure, Joseph J. Del Pizzo, Tianyi Sun, Jim C. Hu, Jialin Mao, and Art Sedrakyan
Subjects: Male, medicine.medical_specialty, Time Factors, Databases, Factual, Biopsy, Medicare, Predictive Value of Tests, medicine, Renal mass, Humans, Radiology, Nuclear Medicine and imaging, Practice Patterns, Physicians', Aged, Neoplasm Staging, Aged, 80 and over, medicine.diagnostic_test, business.industry, Kidney Neoplasms, United States, Tumor Burden, Female, Radiology, Cardiology and Cardiovascular Medicine, business, SEER Program
Published: 2020
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29. Orthopnea in a 10‐Year‐Old

Author: Max Pizzo
Subjects: medicine.medical_specialty, Orthopnea, business.industry, Internal medicine, Cardiology, medicine, medicine.symptom, business
Published: 2020
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30. Addressing Antibiotic Hip Spacer Instability via Hybrid Screw-cement Fixation of a Constrained Liner and Cement-rebar Interface Techniques

Author: Richard A Pizzo, Jay N. Patel, Frank A. Liporace, and Richard S. Yoon
Subjects: Reoperation, musculoskeletal diseases, Prosthesis-Related Infections, Arthroplasty, Replacement, Hip, medicine.medical_treatment, Bone Screws, Rebar, Periprosthetic, Dentistry, medicine.disease_cause, Weight-bearing, law.invention, 03 medical and health sciences, Fixation (surgical), Postoperative Complications, 0302 clinical medicine, law, Humans, Medicine, Orthopedics and Sports Medicine, Cement, 030222 orthopedics, Femur fracture, business.industry, Bone Cements, 030229 sport sciences, Combined Modality Therapy, Arthroplasty, Anti-Bacterial Agents, Surgery, Cement fixation, business
Abstract: Prosthetic joint infection is a challenging and devastating complication after total hip arthroplasty. The benchmark for treatment remains two-stage revision arthroplasty, in which an antibiotic-impregnated spacer is used to eradicate the infection. Although several types of spacer constructs have been described, they have historically been associated with high rates of mechanical complications, namely, dislocation, spacer fracture, and periprosthetic femur fracture. Spacer dislocation is the most common, with reported rates as high as 41%. Here, the authors present a surgical technique to improve the mechanical stability of an articulating hip spacer via a hybrid screw-cement fixation technique that allows for joint motion and weight bearing during the treatment period while minimizing the risk of mechanical failure. An additional technique is described to address acetabular bone loss, which has been associated with a higher spacer dislocation rate, through a cement-rebar interface construct.
Published: 2020
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31. The ASCEND study: protocol for a feasibility study to evaluate an early social communication intervention for young children with Down syndrome

Author: Maria Breen, Hayley Perry, Vesna Stojanovik, Kate Harvey, Susie Jennings, Elena Pizzo, Victoria Joffe, Emma Pagnamenta, and Emily Seager
Subjects: Protocol (science), Down syndrome, medicine.medical_specialty, Medicine (General), Social communication, business.industry, Medicine (miscellaneous), Intervention, medicine.disease, Study Protocol, R5-920, Intervention (counseling), Physical therapy, Medicine, business, Language
Abstract: BackgroundDown syndrome is the most common cause of learning disability, affecting approximately 1 in every 700 babies. Children with Down syndrome have particular difficulties with speech and language. This makes it challenging for them to participate fully in life, access healthcare services and educational opportunities. Improving the language skills of young children with Down syndrome is vital for their future social and emotional well-being and behaviour, and consequently contribution to society. As Down syndrome is detected before or at birth, we can provide support from early on. There are currently no standard interventions for improving the language skills of children with Down syndrome under the age of 36 months. Evidence suggests that early parent-based interventions may be effective in improving language outcomes. In partnership with parents and speech and language therapists, we have co-developed an intervention focusing on early social communication skills and our preliminary work shows that it can lead to better language in children with Down syndrome. Our aim is to carry out a feasibility study which will inform a future pilot/full trial to test whether the intervention is effective in improving language skills before children with Down syndrome start school.MethodsThis is a two-arm feasibility randomised controlled trial (RCT), with 1:1 randomisation stratified by trial site comparing the intervention (plus standard NHS speech and language therapy) with no intervention (standard NHS speech and language therapy only). We aim to recruit between 25 and 30 children with Down syndrome aged between 11 and 36 months. Sites are defined by the geographical boundaries of three National Health Service (NHS) Trusts. Recruitment is from NHS Speech and Language Therapist caseloads within the 3 Trusts, and self-referral. In the intervention arm, parents/guardians will receive brief training on the parent-based intervention and a manual to follow with their child for 10 weeks. The children’s language and early communication skills and family health outcomes will be assessed by a blinded assessor at baseline, post-intervention and 6 month follow-up. Questionnaire and semi-structured interviews will explore the acceptability of the intervention to parents and SLTs.DiscussionThe feasibility study’s outcomes will determine whether it would be viable to progress to a full-trial and whether adjustments need to made to the procedures, data collection methods, intervention delivery and the intensity of support needed. We want to assess whether our early intervention can be delivered and rolled out through NHS Speech and Language Therapy (SLT) Services. We anticipate that NHS SLT Services will need to make ongoing changes due to the COVID-19 pandemic, so it is likely that we will need to make adjustments for the definitive trial. We will also calculate descriptive statistics of the language outcome measure which we will use for any future sample size calculation.Trial registrationISRCTN13902755. Registered on 25 August 2020.http://www.isrctn.com/ISRCTN13902755
Published: 2022
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32. Longitudinal Circulating Levels of miR-23b-3p, miR-126-3p and lncRNA GAS5 in HCC Patients Treated with Sorafenib

Author: Manuela Ferracin, Nazario Portolani, Massimo Negrini, Sarah Molfino, Rodolfo Passalacqua, Michele Manganelli, Gian Luca Baiocchi, Alessandro Salvi, Ilaria Grossi, Claudio Pizzo, Margherita Ratti, Paola Guerriero, Giuseppina De Petro, Chiara Senti, Eleonora Marchina, Michele Ghidini, Manganelli M., Grossi I., Ferracin M., Guerriero P., Negrini M., Ghidini M., Senti C., Ratti M., Pizzo C., Passalacqua R., Molfino S., Baiocchi G., Portolani N., Marchina E., De Petro G., and Salvi A.
Subjects: 0301 basic medicine, Oncology, Sorafenib, medicine.medical_specialty, QH301-705.5, Medicine (miscellaneous), ddPCR, General Biochemistry, Genetics and Molecular Biology, Article, NO, miR-23b-3p, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, microRNA, GAS5, medicine, miR-126-3p, Clinical significance, Digital polymerase chain reaction, Biology (General), HCC, HCC, sorafenib, ddPCR, GAS5, miR-126-3, miR-23b-3p, neoplasms, miR-126-3, business.industry, medicine.disease, Primary tumor, digestive system diseases, sorafenib, 030104 developmental biology, 030220 oncology & carcinogenesis, Hepatocellular carcinoma, Cohort, business, medicine.drug
Abstract: Human hepatocellular carcinoma (HCC) is the most frequent primary tumor of the liver and the third cause of cancer-related deaths. The multikinase inhibitor sorafenib is a systemic drug for unresectable HCC. The identification of molecular biomarkers for the early diagnosis of HCC and responsiveness to treatment are needed. In this work, we performed an exploratory study to investigate the longitudinal levels of cell-free long ncRNA GAS5 and microRNAs miR-126-3p and -23b-3p in a cohort of 7 patients during the period of treatment with sorafenib. We used qPCR to measure the amounts of GAS5 and miR-126-3p and droplet digital PCR (ddPCR) to measure the levels of miR-23b-3p. Patients treated with sorafenib displayed variable levels of GAS5, miR-126-3p and miR-23b-3p at different time-points of follow-up. miR-23b-3p was further measured by ddPCR in 37 healthy individuals and 25 untreated HCC patients. The amount of miR-23b-3p in the plasma of untreated HCC patients was significantly downregulated if compared to healthy individuals. The ROC curve analysis underlined its diagnostic relevance. In conclusion, our results highlight a potential clinical significance of circulating miR-23b-3p and an exploratory observation on the longitudinal plasmatic levels of GAS5, miR-126-3p and miR-23b-3p during sorafenib treatment.
Published: 2021

33. PNPLA3 and TLL-1 Polymorphisms as Potential Predictors of Disease Severity in Patients With COVID-19

Author: Davide Stefano Sardina, Francesco Vitale, Tullio Prestileo, Emanuele Amodio, Antonio Craxì, Stefania Grimaudo, Alessandra Casuccio, Fabio Tramuto, Stefano Pizzo, Rosaria Maria Pipitone, Carmelo Massimo Maida, Grimaudo S., Amodio E., Pipitone R.M., Maida C.M., Pizzo S., Prestileo T., Tramuto F., Sardina D., Vitale F., Casuccio A., and Craxi A.
Subjects: 0301 basic medicine, severity of disease, QH301-705.5, Inflammation, Pathogenesis, Cell and Developmental Biology, 03 medical and health sciences, 0302 clinical medicine, Downregulation and upregulation, Genotype, medicine, genetic polymorphism, Biology (General), Gene, Original Research, business.industry, Confounding, COVID-19, Inflammasome, Cell Biology, MERTK, 030104 developmental biology, 030220 oncology & carcinogenesis, Immunology, medicine.symptom, business, PNPLA3 I148M, TLL-1, Developmental Biology, medicine.drug
Abstract: Albeit the pathogenesis of COVID-19 remains unclear, host’s genetic polymorphisms in genes involved in infection and reinfection, inflammation, or immune stimulation could play a role in determining the course and outcome. We studied in the early phase of pandemic consecutive patients (N = 383) with SARS-CoV-2 infection, whose subsequent clinical course was classified as mild or severe, the latter being characterized by admission to intensive therapy unit or death. Five host gene polymorphisms (MERTK rs4374383, PNPLA3 rs738409, TLL-1 rs17047200, IFNL3 rs1297860, and INFL4 rs368234815) were assessed by using whole nucleic acids extracted from nasopharyngeal swabs. Specific protease cleavage sites of TLL-1 on the SARS-CoV-2 Spike protein were predicted in silico. Male subjects and older patients were significantly at higher risk for a severe outcome (p = 0.02 and p < 0.001, respectively). By considering patients ≤65 years, after adjusting for potential confounding due to sex, an increased risk of severe outcome was found in subjects with the GG genotype of PNPLA3 (adj-OR: 4.69; 95% CI = 1.01–22.04) or TT genotype of TLL-1 (adj-OR=9.1; 95% CI = 1.45–57.3). In silico evaluation showed that TLL-1 is potentially involved in the Spike protein cleavage which is essential for viral binding and entry into the host cells using the host receptor angiotensin-converting enzyme 2 (ACE2). Subjects carrying a GG genotype in PNPLA3 gene might have a constitutive upregulation of the NLRP3 inflammasome and be more prone to tissue damage when infected by SARS-CoV-2. The TT genotype in TLL-1 gene might affect its protease activity on the SARS-CoV-2 Spike protein, enhancing the ability to infect or re-infect host’s cells. The untoward effect of these variants on disease course is evident in younger patients due to the relative absence of comorbidities as determinants of prognosis. In the unresolved pathogenetic scenery of COVID-19, the identification of genetic variants associates with more prolonged course or with a severe outcome of infection would support the development of predictive tools useful to stratify subjects by risk class at presentation. Moreover, the individuation of key genes could contribute to a better understanding of the pathways involved in the pathogenesis, giving the basis for rational therapeutic approaches.
Published: 2021
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34. A case of infective colitis due to Yersinia enterocolitica complicated by microliver abscesses mimicking multiple liver occult metastases: a case report

Author: Marco Cataldi, Giuseppe Brancatelli, Chiara Pintus, Antonino Tuttolomondo, Valerio Vassallo, Salvatore Miceli, Rosario Luca Norrito, Mario Daidone, Maria Grazia Puleo, Alessandro Del Cuore, Tiziana Di Chiara, G. Pizzo, Antonio Pinto, Norrito R.L., Pintus C., Cataldi M., Del Cuore A., Daidone M., Vassallo V., Puleo M.G., Di Chiara T., Miceli S., Pizzo G.M., Brancatelli G., Tuttolomondo A., and Pinto A.
Subjects: 0301 basic medicine, medicine.medical_specialty, Settore MED/09 - Medicina Interna, Case report, Infective colitis, Microliver abscesses, Yersinia enterocolitica, Aged, Anti-Bacterial Agents, Bacteremia, Liver Neoplasms, Treatment Outcome, Yersinia Infections, Colitis, Diagnosis, Differential, Female, Humans, Liver Abscess, Yersinia Infections, 030106 microbiology, Liver Abscess, Infective colitis, Case Report, Bacteremia, Infectious and parasitic diseases, RC109-216, Inflammatory bowel disease, Gastroenterology, Metastasis, Diagnosis, Differential, 03 medical and health sciences, 0302 clinical medicine, Medical microbiology, Internal medicine, medicine, Humans, 030212 general & internal medicine, Yersinia enterocolitica, Aged, Doxycycline, biology, business.industry, Liver Neoplasms, Microliver abscesses, medicine.disease, biology.organism_classification, Colitis, Occult, Anti-Bacterial Agents, Infectious Diseases, Treatment Outcome, Female, Differential diagnosis, business, Cefixime, medicine.drug
Abstract: Background We report an unusual case of infective colitis by Yersinia enterocolitica complicated by microliver abscesses mimicking multiple liver metastases in a 79 yr old female without any risk factors for bacteriaemia by this pathogen. Case presentation The patient was admitted to the Internal Medicine with Stroke Care ward of University Policlinico “P. Giaccone” in Palermo because of the appearance of diarrhoea. After the antimicrobial treatment for infective colitis, the clinicians observed a persistently increased white blood cells (WBC) count and multiple hepatic lesions; after having excluded any neoplastic disease and inflammatory bowel disease (IBD), blood cultures positive for Y. enterocolitica allowed to establish the final diagnosis was infective micro liver abscesses consequent to infective colitis due to Y. enterocolitica, which were successfully treated with cefixime and doxycycline. Conclusions This case report should make clinicians reflect on how complex the differential diagnosis between microliver abscesses and metastasis could be and the possibility of bacteriaemia by Y. enterocolitica even without iron overload conditions.
Published: 2021

35. An Animal-Assisted Education Intervention with Dogs to Promote Emotion Comprehension in Primary School Children-The Federico II Model of Healthcare Zooanthropology

Author: Cristiano Scandurra, Serena Cristiano, Lucia Francesca Menna, Vincenzo Bochicchio, Antonio Santaniello, Fabrizio Mezza, Susanne Garzillo, Rosa Pizzo, Scandurra, Cristiano, Santaniello, Antonio, Cristiano, Serena, Mezza, Fabrizio, Garzillo, Susanne, Pizzo, Rosa, Menna, LUCIA FRANCESCA, and Bochicchio, Vincenzo
Subjects: Education intervention, dogs, Veterinary medicine, school, Group format, animal-assisted intervention, 050109 social psychology, emotional development, Article, one health, Emotion comprehension, Intervention (counseling), Health care, SF600-1100, Medicine, inter-specific relationship, 0501 psychology and cognitive sciences, Competence (human resources), Peer interaction, General Veterinary, business.industry, 05 social sciences, human–animal interaction, QL1-991, dog, Animal Science and Zoology, Analysis of variance, business, Zoology, 050104 developmental & child psychology, Clinical psychology
Abstract: Simple Summary Children’s understanding of the nature, causes, and regulation of emotions represents a crucial developmental competence, as it improves the quality of peer interactions and increases educational success. This study presents an animal-assisted education intervention model with dogs to promote emotion comprehension in a group of children aged 6–7 years. Children who benefitted from the intervention improved their emotion comprehension compared to children who did not benefit from it. This improvement may be due to the beneficial role of relationships with companion animals, as they seem to positively affect social and emotional development in children, as well as enhancing their social competence, emotion regulation, and empathy. Further psychological processes which may have influenced the positive outcomes achieved are the group dynamics and role model offered by the relationship between the dog and the zootherapist veterinarian. Abstract Emotion comprehension (EC) is a crucial competence for children, as it determines the quality of peer interactions. This study assessed the efficacy of an animal-assisted education (AAE) intervention with dogs based on the Federico II Model of Healthcare Zooanthropology (FMHZ) to promote EC in a group of primary school children. One hundred and four children (48 females) aged 6–7 years took part in the study, of whom 63 participated in the AAE intervention (i.e., experimental group) and 41 did not (i.e., control group). The intervention was deployed in a school setting through a group format and consisted of five bimonthly sessions. EC was assessed pre- and post-intervention, and at a 3-month follow-up. Student’s t-test and mixed-model ANOVA were performed to analyze the effect of the intervention on EC. EC significantly improved in children of the experimental group compared to the control group. Significant time effects from pre- to post-intervention, post-intervention to follow-up, and pre-intervention to follow-up assessment were found in the experimental group only. AAE based on FMHZ was effective in improving EC in children.
Published: 2021

36. Ready, set; go: helping physicians move to value as MACRA begins

Author: Pizzo, James J., Pryor, Robert W., and York, Robert W.
Subjects: Value-based insurance design -- Laws, regulations and rules, Physicians -- Compensation and benefits, Medicare -- Laws, regulations and rules, Government regulation, Business, Health care industry, Medicare Access and CHIP Reauthorization Act of 2015
Abstract: Passed with the broad bipartisan support of Congress in 2015, the Medicare Access and CHIP Reauthorization Act (MACRA) will bring about comprehensive changes to how Medicare pays for physician services. [...]
Published: 2016

37. Comparison of newly proposed test methods to evaluate the bonding quality of Cross-Laminated Timber (CLT) panels by means of experimental data and finite element (FE) analysis

Author: Betti, Michele, Brunetti, Michele, Lauriola, Marco Pio, Nocetti, Michela, Ravalli, Francesco, and Pizzo, Benedetto
Subjects: Shear (Mechanics) -- Comparative analysis, Forest products -- Mechanical properties -- Analysis, Business, Construction and materials industries
Abstract: ABSTRACT The effectiveness of new shear test methods for evaluating the face-bonding quality of Cross-Laminated Timber (CLT) panels was examined by comparing experimental data and numerical modelling. The common characteristic [...]
Published: 2016
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38. Four strategies for succeeding with bundled payments

Author: Pizzo, James J. and Ryan, Debra L.
Subjects: United States. Centers for Medicare and Medicaid Services -- Services -- Planning, Health care industry -- Quality management -- Industry forecasts -- Economic aspects, Prospective payment systems (Medical care) -- Usage, Health care industry, Company business planning, Business
Abstract: As hospitals and health systems move toward a value-based business model, bundled arrangements have become, and likely will continue to be, a key area of focus. This episode-of-care arrangement is [...]
Published: 2016

39. Assessing the wood compressive strength in pile foundations in relation to diagnostic analysis: the example of the Church of Santa Maria Maggiore, Venice

Author: Pizzo, Benedetto, Macchioni, Nicola, Capretti, Chiara, Pecoraro, Elisa, Sozzi, Lorena, and Fiorentino, Luigi
Subjects: Residual stresses -- Analysis, Building materials -- Structure -- Mechanical properties -- Analysis, Lignin -- Materials -- Analysis, Business, Construction and materials industries
Abstract: ABSTRACT Foundation piles are a noteworthy example of waterlogged wood still constituting load bearing structures. Micromorphological analysis, investigation of physical properties (water content, residual basic density), compressive tests in wet [...]
Published: 2016
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40. Four ways to better time the transition to value

Author: Pizzo, James J. and Cohen, Andrew S.
Subjects: Health care costs -- Methods -- Laws, regulations and rules, Physicians -- Services, Health care industry -- Services -- Laws, regulations and rules, Health insurance -- Evaluation -- Influence -- Laws, regulations and rules, Health care industry, Government regulation, Business
Abstract: Many hospital systems, physician groups, and other providers are working hard to transition to value-based care delivery, offering the 'supply side' of care with improved quality, access, and outcomes at [...]
Published: 2016

41. An investigation into preservation of wood from Venice foundations

Author: Macchioni, Nicola, Pizzo, Benedetto, and Capretti, Chiara
Subjects: Wood -- Varieties -- Composition -- Protection and preservation, Historic buildings -- Design and construction, Business, Construction and materials industries
Abstract: ABSTRACT The present paper deals with wood from Venice historic centre foundation elements. Samples were taken from both piles and planking (horizontal elements positioned above the pile heads), in 5 [...]
Published: 2016
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42. Paediatric Sleep Questionnaire for Obstructive Sleep Apnoea Syndrome Screening: Is Sleep Quality Worthy of Note?

Author: Giovanna Giuliana, Paola Spinuzza, Giuseppe Pizzo, Domenica Matranga, Gaetano La Mantia, Laura Maniscalco, Vera Panzarella, Vera Panzarella, Giovanna Giuliana, Paola Spinuzza, Gaetano La Mantia, Laura Maniscalco, Giuseppe Pizzo, and Domenica Matranga
Subjects: Pediatrics, medicine.medical_specialty, Quality of sleep, Disease, lcsh:Technology, Settore MED/01 - Statistica Medica, lcsh:Chemistry, 03 medical and health sciences, 0302 clinical medicine, Settore MED/28 - Malattie Odontostomatologiche, Positive predicative value, Medicine, screening accuracy, General Materials Science, paediatric sleep-related breathing disorders, lcsh:QH301-705.5, Instrumentation, Obstructive sleep apnoea syndrome, Paediatric Sleep Questionnaire (PSQ), Fluid Flow and Transfer Processes, Sleep quality, lcsh:T, business.industry, Process Chemistry and Technology, Abnormal positions, General Engineering, paediatric obstructive sleep apnoea syndrome, Sleep in non-human animals, lcsh:QC1-999, Computer Science Applications, lcsh:Biology (General), lcsh:QD1-999, 030228 respiratory system, lcsh:TA1-2040, sleep quality disturbance, lcsh:Engineering (General). Civil engineering (General), business, paediatric sleep-related breathing disorder, lcsh:Physics, 030217 neurology & neurosurgery, Paediatric population
Abstract: Obstructive sleep apnoea syndrome (OSAS) is the most severe condition on the spectrum of sleep-related breathing disorders (SRBDs). The Paediatric Sleep Questionnaire (PSQ) is one of the most used and validated screening tools, but it lacks the comprehensive assessment of some determinants of OSAS, specifically anamnestic assessment and sleep quality. This study aims to assess the accuracy of some specific items added to the original PSQ, particularly related to the patient’s anamnestic history and to the quality of sleep, for the screening of OSAS in a paediatric population living in Sicily (Italy). Fifteen specific items, divided into “anamnestic” and “related to sleep quality” were added to the original PSQ. The whole questionnaire was administered via a digital form to the parents of children at 4 schools (age range: 3–13 years). For each item, sensitivity and specificity, positive and negative predictive values, and positive and negative likelihood ratios were calculated. The highest sensitivity (80.0, 95% CI: 28.4, 99.5), in combination with the highest specificity (61.1, 95% CI: 35.7, 82.7), was found for the Item 32 (“assumption of bizarre or abnormal positions during sleep”). This item was found statistically significant for predicting the occurrence of OSAS in children (p-value ≤0.003). The study demonstrates the accuracy of specific items related to sleep quality disturbance for the preliminary assessment of the disease. Although these results should be validated on a larger sample of subjects, they suggest that including the factors discriminating sleep quality could further increase the efficiency and accuracy of PSQ.
Published: 2021
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43. Community Occupational Therapy for people with dementia and family carers (COTiD-UK) versus treatment as usual (Valuing Active Life in Dementia [VALID]) study: A single-blind, randomised controlled trial

Author: Martin Orrell, Nadia Crellin, Michael King, Maud Graff, Stephen Morris, Jane Burgess, Jacqueline Mundy, Esme Moniz-Cook, Jacki Stansfeld, Aidan G. O'Keeffe, Jennifer Wenborn, Ian Russell, Myrra Vernooij-Dassen, Tom Swinson, Elena Pizzo, Fiona Poland, Gail Mountain, Sinéad M. Hynes, Catherine Sackley, Rumana Z Omar, David Challis, Susan Michie, Wenborn, Jennifer [0000-0001-7311-8972], Mountain, Gail [0000-0002-5417-7691], Moniz-Cook, Esme [0000-0002-7232-4632], King, Michael [0000-0003-4715-7171], Burgess, Jane [0000-0002-4626-6424], Poland, Fiona [0000-0003-0003-6911], Pizzo, Elena [0000-0003-0790-7505], Michie, Susan [0000-0003-0063-6378], Russell, Ian [0000-0002-0069-479X], Sackley, Catherine [0000-0002-8580-6622], Graff, Maud [0000-0003-4361-4291], Swinson, Tom [0000-0003-2314-9193], Crellin, Nadia [0000-0002-9497-5874], Hynes, Sinéad [0000-0002-3199-7355], Stansfeld, Jacki [0000-0002-4491-5523], Orrell, Martin [0000-0002-1169-3530], Apollo - University of Cambridge Repository, and National Institute for Health Research
Subjects: Male, Alzheimer`s disease Donders Center for Medical Neuroscience [Radboudumc 1], Activities of daily living, Social Sciences, single-blind, randomised controlled trial, law.invention, 0302 clinical medicine, Randomized controlled trial, Sociology, Occupational Therapy, law, Health care, Activities of Daily Living, Outcome Assessment, Health Care, Medicine and Health Sciences, Applied research, Single-Blind Method, 030212 general & internal medicine, Human Families, Cognitive Impairment, Aged, 80 and over, Measurement, Cognitive Neurology, Depression, family carers (COTiD-UK), treatment as usual, FOS: Social sciences, General Medicine, Middle Aged, Home Care Services, Neurology, Caregivers, England, Valuing Active Life in Dementia [VALID], Medicine, Engineering and Technology, Female, Research Article, Occupational therapy, Adult, medicine.medical_specialty, Drug Research and Development, Cognitive Neuroscience, MEDLINE, Research and Analysis Methods, Healthcare improvement science Radboud Institute for Health Sciences [Radboudumc 18], 03 medical and health sciences, All institutes and research themes of the Radboud University Medical Center, Quality of life (healthcare), Mental Health and Psychiatry, medicine, Dementia, Humans, Clinical Trials, Family, Aged, Pharmacology, business.industry, Mood Disorders, Biology and Life Sciences, medicine.disease, FOS: Engineering and technology, Randomized Controlled Trials, Health Care, Family medicine, Quality of Life, Cognitive Science, Clinical Medicine, business, 030217 neurology & neurosurgery, Neuroscience
Abstract: Background We aimed to estimate the clinical effectiveness of Community Occupational Therapy for people with dementia and family carers–UK version (Community Occupational Therapy in Dementia–UK version [COTiD-UK]) relative to treatment as usual (TAU). We hypothesised that COTiD-UK would improve the ability of people with dementia to perform activities of daily living (ADL), and family carers’ sense of competence, compared with TAU. Methods and findings The study design was a multicentre, 2-arm, parallel-group, assessor-masked, individually randomised controlled trial (RCT) with internal pilot. It was conducted in 15 sites across England from September 2014 to January 2018. People with a diagnosis of mild to moderate dementia living in their own home were recruited in pairs with a family carer who provided domestic or personal support for at least 4 hours per week. Pairs were randomised to either receive COTiD-UK, which comprised 10 hours of occupational therapy delivered over 10 weeks in the person with dementia’s home or TAU, which comprised the usual local service provision that may or may not include standard occupational therapy. The primary outcome was the Bristol Activities of Daily Living Scale (BADLS) score at 26 weeks. Secondary outcomes for the person with dementia included the following: the BADLS scores at 52 and 78 weeks, cognition, quality of life, and mood; and for the family carer: sense of competence and mood; plus the number of social contacts and leisure activities for both partners. Participants were analysed by treatment allocated. A total of 468 pairs were recruited: people with dementia ranged from 55 to 97 years with a mean age of 78.6 and family carers ranged from 29 to 94 with a mean of 69.1 years. Of the people with dementia, 74.8% were married and 19.2% lived alone. Of the family carers, 72.6% were spouses, and 22.2% were adult children. On randomisation, 249 pairs were assigned to COTiD-UK (62% people with dementia and 23% carers were male) and 219 to TAU (52% people with dementia and 32% carers were male). At the 26 weeks follow-up, data were available for 364 pairs (77.8%). The BADLS score at 26 weeks did not differ significantly between groups (adjusted mean difference estimate 0.35, 95% CI −0.81 to 1.51; p = 0.55). Secondary outcomes did not differ between the groups. In total, 91% of the activity-based goals set by the pairs taking part in the COTiD-UK intervention were fully or partially achieved by the final COTiD-UK session. Study limitations include the following: Intervention fidelity was moderate but varied across and within sites, and the reliance on primarily proxy data focused on measuring the level of functional or cognitive impairment which may not truly reflect the actual performance and views of the person living with dementia. Conclusions Providing community occupational therapy as delivered in this study did not improve ADL performance, cognition, quality of life, or mood in people with dementia nor sense of competence or mood in family carers. Future research should consider measuring person-centred outcomes that are more meaningful and closely aligned to participants’ priorities, such as goal achievement or the quantity and quality of activity engagement and participation. Trial Registration Current Controlled Trials ISRCTN10748953., Jennifer Wenborn and colleagues investigate the effectiveness of community occupational therapy program in improving activities of daily living, cognition, and mood for people with dementia., Author summary Why was this study done? Maintaining everyday and pleasurable activities can be difficult for a person with dementia, as well as their family carer who often feels increasingly stressed as they need to give more and more support. Occupational therapists assist people to improve their health and well-being through carrying on with the activities they need and want to do. It is therefore important to develop effective strategies to deliver occupational therapy to people with dementia and their family carers who support them. What did the researchers do and find? We tested the effectiveness of the Community Occupational Therapy in Dementia–UK version (COTiD-UK) programme compared to the care that people with mild to moderate dementia and their family carers usually receive, through a clinical trial. We recruited 468 pairs comprising a person with dementia and a family carer across England who were randomly allocated to either take part in the COTiD-UK programme or to continue with their usual care. We found no statistical evidence that COTiD-UK gave more benefit to people with dementia or their carers than the usual care provided in terms of the people with dementia being able to carry out activities or their mood or quality of life nor their family carers’ sense of competence or mood. The pairs who took part in the COTiD-UK intervention set an average of 4.09 goals each, of which 91% were fully or partially achieved by the final COTiD-UK session. What do these findings mean? We did not find evidence to support commissioning the COTiD-UK intervention for people with mild to moderate dementia and their family carers. Future studies need to develop more realistic methods of measuring the effectiveness of programmes such as this, particularly to focus on the outcomes that most matter to the individuals taking part and to truly reflect the actual performance, experience, and views of the person living with dementia.
Published: 2021

44. Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition) 1

Author: Klionsky, Daniel, Abdel-Aziz, Amal Kamal, Abdelfatah, Sara, Abdellatif, Mahmoud, Abdoli, Asghar, Abel, Steffen, Abeliovich, Hagai, Abildgaard, Marie, Abudu, Yakubu Princely, Acevedo-Arozena, Abraham, Adamopoulos, Iannis, Adeli, Khosrow, Adolph, Timon, Adornetto, Annagrazia, Aflaki, Elma, Agam, Galila, Agarwal, Anupam, Aggarwal, Bharat, Agnello, Maria, Agostinis, Patrizia, Agrewala, Javed, Agrotis, Alexander, Aguilar, Patricia, Ahmad, S Tariq, Ahmed, Zubair, Ahumada-Castro, Ulises, Aits, Sonja, Aizawa, Shu, Akkoc, Yunus, Akoumianaki, Tonia, Akpinar, Hafize Aysin, Al-Abd, Ahmed, Al-Akra, Lina, Al-Gharaibeh, Abeer, Alaoui-Jamali, Moulay, Alberti, Simon, Alcocer-Gómez, Elísabet, Alessandri, Cristiano, Ali, Muhammad, Alim Al-Bari, M Abdul, Aliwaini, Saeb, Alizadeh, Javad, Almacellas, Eugènia, Almasan, Alexandru, Alonso, Alicia, Alonso, Guillermo, Altan-Bonnet, Nihal, Altieri, Dario, Álvarez, Élida, Alves, Sara, Alves Da Costa, Cristine, Alzaharna, Mazen, Amadio, Marialaura, Amantini, Consuelo, Amaral, Cristina, Ambrosio, Susanna, Amer, Amal, Ammanathan, Veena, An, Zhenyi, Andersen, Stig, Andrabi, Shaida, Andrade-Silva, Magaiver, Andres, Allen, Angelini, Sabrina, Ann, David, Anozie, Uche, Ansari, Mohammad, Antas, Pedro, Antebi, Adam, Antón, Zuriñe, Anwar, Tahira, Apetoh, Lionel, Apostolova, Nadezda, Araki, Toshiyuki, Araki, Yasuhiro, Arasaki, Kohei, Araújo, Wagner, Araya, Jun, Arden, Catherine, Arévalo, Maria-Angeles, Arguelles, Sandro, Arias, Esperanza, Arikkath, Jyothi, Arimoto, Hirokazu, Ariosa, Aileen, Armstrong-James, Darius, Arnauné-Pelloquin, Laetitia, Aroca, Angeles, Arroyo, Daniela, Arsov, Ivica, Artero, Rubén, Asaro, Dalia Maria Lucia, Aschner, Michael, Ashrafizadeh, Milad, Ashur-Fabian, Osnat, Atanasov, Atanas, Au, Alicia, Auberger, Patrick, Auner, Holger, Aurelian, Laure, Autelli, Riccardo, Avagliano, Laura, Ávalos, Yenniffer, Aveic, Sanja, Aveleira, Célia Alexandra, Avin-Wittenberg, Tamar, Aydin, Yucel, Ayton, Scott, Ayyadevara, Srinivas, Azzopardi, Maria, Baba, Misuzu, Backer, Jonathan, Backues, Steven, Bae, Dong-Hun, Bae, Ok-Nam, Bae, Soo Han, Baehrecke, Eric, Baek, Ahruem, Baek, Seung-Hoon, Baek, Sung Hee, Bagetta, Giacinto, Bagniewska-Zadworna, Agnieszka, Bai, Hua, Bai, Jie, Bai, Xiyuan, Bai, Yidong, Bairagi, Nandadulal, Baksi, Shounak, Balbi, Teresa, Baldari, Cosima, Balduini, Walter, Ballabio, Andrea, Ballester, Maria, Balazadeh, Salma, Balzan, Rena, Bandopadhyay, Rina, Banerjee, Sreeparna, Banerjee, Sulagna, Bánréti, Ágnes, Bao, Yan, Baptista, Mauricio, Baracca, Alessandra, Barbati, Cristiana, Bargiela, Ariadna, Barilà, Daniela, Barlow, Peter, Barmada, Sami, Barreiro, Esther, Barreto, George, Bartek, Jiri, Bartel, Bonnie, Bartolome, Alberto, Barve, Gaurav, Basagoudanavar, Suresh, Bassham, Diane, Bast, Robert, Basu, Alakananda, Batoko, Henri, Batten, Isabella, Baulieu, Etienne, Baumgarner, Bradley, Bayry, Jagadeesh, Beale, Rupert, Beau, Isabelle, Beaumatin, Florian, Bechara, Luiz, Beck, George, Beers, Michael, Begun, Jakob, Behrends, Christian, Behrens, Georg, Bei, Roberto, Bejarano, Eloy, Bel, Shai, Behl, Christian, Belaid, Amine, Belgareh-Touzé, Naïma, Bellarosa, Cristina, Belleudi, Francesca, Belló Pérez, Melissa, Bello-Morales, Raquel, Beltran, Jackeline Soares de Oliveira, Beltran, Sebastián, Benbrook, Doris Mangiaracina, Bendorius, Mykolas, Benitez, Bruno, Benito-Cuesta, Irene, Bensalem, Julien, Berchtold, Martin, Berezowska, Sabina, Bergamaschi, Daniele, Bergami, Matteo, Bergmann, Andreas, Berliocchi, Laura, Berlioz-Torrent, Clarisse, Bernard, Amélie, Berthoux, Lionel, Besirli, Cagri, Besteiro, Sebastien, Betin, Virginie, Beyaert, Rudi, Bezbradica, Jelena, Bhaskar, Kiran, Bhatia-Kissova, Ingrid, Bhattacharya, Resham, Bhattacharya, Sujoy, Bhattacharyya, Shalmoli, Bhuiyan, Md Shenuarin, Bhutia, Sujit Kumar, Bi, Lanrong, Bi, Xiaolin, Biden, Trevor, Bijian, Krikor, Billes, Viktor, Binart, Nadine, Bincoletto, Claudia, Birgisdottir, Asa, Bjorkoy, Geir, Blanco, Gonzalo, Blas-Garcia, Ana, Blasiak, Janusz, Blomgran, Robert, Blomgren, Klas, Blum, Janice, Boada-Romero, Emilio, Boban, Mirta, Boesze-Battaglia, Kathleen, Boeuf, Philippe, Boland, Barry, Bomont, Pascale, Bonaldo, Paolo, Bonam, Srinivasa Reddy, Bonfili, Laura, Bonifacino, Juan, Boone, Brian, Bootman, Martin, Bordi, Matteo, Borner, Christoph, Bornhauser, Beat, Borthakur, Gautam, Bosch, Jürgen, Bose, Santanu, botana, luis, Botas, Juan, Boulanger, Chantal, Boulton, Michael, Bourdenx, Mathieu, Bourgeois, Benjamin, Bourke, Nollaig, Bousquet, Guilhem, Boya, Patricia, Bozhkov, Peter, Bozi, Luiz, Bozkurt, Tolga, Brackney, Doug, Brandts, Christian, Braun, Ralf, Braus, Gerhard, Bravo-Sagua, Roberto, Bravo-San Pedro, José, Brest, Patrick, Bringer, Marie-Agnès, Briones-Herrera, Alfredo, Broaddus, V Courtney, Brodersen, Peter, Brodsky, Jeffrey, Brody, Steven, Bronson, Paola, Bronstein, Jeff, Brown, Carolyn, Brown, Rhoderick, Brum, Patricia, Brumell, John, Brunetti-Pierri, Nicola, Bruno, Daniele, Bryson-Richardson, Robert, Bucci, Cecilia, Buchrieser, Carmen, Bueno, Marta, Buitrago-Molina, Laura Elisa, Buraschi, Simone, Buch, Shilpa, Buchan, J Ross, Buckingham, Erin, Budak, Hikmet, Budini, Mauricio, Bultynck, Geert, Burada, Florin, Burgoyne, Joseph, Burón, M Isabel, Bustos, Victor, Büttner, Sabrina, Butturini, Elena, Byrd, Aaron, Cabas, Isabel, Cabrera-Benitez, Sandra, Cadwell, Ken, Cai, Jingjing, Cai, Lu, Cai, Qian, Cairó, Montserrat, Calbet, Jose, Caldwell, Guy, Caldwell, Kim, Call, Jarrod, Calvani, Riccardo, Calvo, Ana, Calvo-Rubio Barrera, Miguel, Camara, Niels OS, Camonis, Jacques, Camougrand, Nadine, Campanella, Michelangelo, Campbell, Edward, Campbell-Valois, François-Xavier, Campello, Silvia, Campesi, Ilaria, Campos, Juliane, Camuzard, Olivier, Cancino, Jorge, Candido de Almeida, Danilo, Canesi, Laura, Caniggia, Isabella, Canonico, Barbara, Cantí, Carles, Cao, Bin, Caraglia, Michele, Caramés, Beatriz, Carchman, Evie, Cardenal-Muñoz, Elena, Cardenas, Cesar, Cardenas, Luis, Cardoso, Sandra, Carew, Jennifer, Carle, Georges, Carleton, Gillian, Carloni, Silvia, Carmona-Gutierrez, Didac, Carneiro, Leticia, Carnevali, Oliana, Carosi, Julian, Carra, Serena, Carrier, Alice, Carrier, Lucie, Carroll, Bernadette, Carter, A Brent, Carvalho, Andreia Neves, Casanova, Magali, Casas, Caty, Casas, Josefina, Cassioli, Chiara, Castillo, Eliseo, Castillo, Karen, Castillo-Lluva, Sonia, Castoldi, Francesca, Castori, Marco, Castro, Ariel, Castro-Caldas, Margarida, Castro-Hernandez, Javier, Castro-Obregon, Susana, Catz, Sergio, Cavadas, Claudia, Cavaliere, Federica, Cavallini, Gabriella, Cavinato, Maria, Cayuela, Maria, Cebollada Rica, Paula, Cecarini, Valentina, Cecconi, Francesco, Cechowska-Pasko, Marzanna, Cenci, Simone, Ceperuelo-Mallafré, Victòria, Cerqueira, João, Cerutti, Janete, Cervia, Davide, Cetintas, Vildan Bozok, Cetrullo, Silvia, Chae, Han-Jung, Chagin, Andrei, Chai, Chee-Yin, Chakrabarti, Gopal, Chakrabarti, Oishee, Chakraborty, Tapas, Chakraborty, Trinad, Chami, mounia, Chamilos, Georgios, Chan, David, Chan, Edmond, Chan, Edward, Chan, H.Y. Edwin, Chan, Helen, Chan, Hung, Chan, Matthew, Chan, Yau Sang, Chandra, Partha, Chang, Chih-Peng, Chang, Chunmei, Chang, Hao-Chun, Chang, Kai, Chao, Jie, Chapman, Tracey, Charlet-Berguerand, Nicolas, Chatterjee, Samrat, Chaube, Shail, Chaudhary, Anu, Chauhan, Santosh, Chaum, Edward, Checler, Frédéric, Cheetham, Michael, Chen, Chang-Shi, Chen, Guang-Chao, Chen, Jian-Fu, Chen, Liam, Chen, Leilei, Chen, Lin, Chen, Mingliang, Chen, Mu-Kuan, Chen, Ning, Chen, Quan, Chen, Ruey-Hwa, Chen, Shi, Chen, Wei, Chen, Weiqiang, Chen, Xin-Ming, Chen, Xiong-Wen, Chen, Xu, Chen, Yan, Chen, Ye-Guang, Chen, Yingyu, Chen, Yongqiang, Chen, Yu-Jen, Chen, Yue-Qin, Chen, Zhefan Stephen, Chen, Zhi, Chen, Zhi-Hua, Chen, Zhijian, Chen, Zhixiang, Cheng, Hanhua, Cheng, Jun, Cheng, Shi-Yuan, Cheng, Wei, Cheng, Xiaodong, Cheng, Xiu-Tang, Cheng, Yiyun, Cheng, Zhiyong, Chen, Zhong, Cheong, Heesun, Cheong, Jit Kong, Chernyak, Boris, Cherry, Sara, Cheung, Chi Fai Randy, Cheung, Chun Hei Antonio, Cheung, King-Ho, Chevet, Eric, Chi, Richard, Chiang, Alan Kwok Shing, Chiaradonna, Ferdinando, Chiarelli, Roberto, Chiariello, Mario, Chica, Nathalia, Chiocca, Susanna, Chiong, Mario, Chiou, Shih-Hwa, Chiramel, Abhilash, Chiurchiù, Valerio, Cho, Dong-Hyung, Choe, Seong-Kyu, Choi, Augustine, Choi, Mary, Choudhury, Kamalika Roy, Chow, Norman, Chu, Charleen, Chua, Jason, Chua, John Jia En, Chung, Hyewon, Chung, Kin Pan, Chung, Seockhoon, Chung, So-Hyang, Chung, Yuen-Li, Cianfanelli, Valentina, Ciechomska, Iwona, Cifuentes, Mariana, Cinque, Laura, Cirak, Sebahattin, Cirone, Mara, Clague, Michael, Clarke, Robert, Clementi, Emilio, Coccia, Eliana, Codogno, Patrice, Cohen, Ehud, Cohen, Mickael, Colasanti, Tania, Colasuonno, Fiorella, Colbert, Robert, Colell, Anna, Čolić, Miodrag, Coll, Nuria, Collins, Mark, Colombo, María, Colón-Ramos, Daniel, Combaret, Lydie, Comincini, Sergio, Cominetti, Márcia, Consiglio, Antonella, Conte, Andrea, Conti, Fabrizio, Contu, Viorica Raluca, Cookson, Mark, Coombs, Kevin, Coppens, Isabelle, Corasaniti, Maria Tiziana, Corkery, Dale, Cordes, Nils, Cortese, Katia, Costa, Maria do Carmo, Costantino, Sarah, Costelli, Paola, Coto-Montes, Ana, Crack, Peter, Crespo, Jose, Criollo, Alfredo, Crippa, Valeria, Cristofani, Riccardo, Csizmadia, Tamas, Cuadrado, Antonio, Cui, Bing, Cui, Jun, Cui, Yixian, Cui, Yong, Culetto, Emmanuel, Cumino, Andrea, Cybulsky, Andrey, Czaja, Mark, Czuczwar, Stanislaw, D'Adamo, Stefania, D'Amelio, Marcello, D'Arcangelo, Daniela, D'Lugos, Andrew, D'Orazi, Gabriella, da Silva, James, Dafsari, Hormos Salimi, Dagda, Ruben, Dagdas, Yasin, Daglia, Maria, Dai, Xiaoxia, Dai, Yun, Dai, Yuyuan, Dal Col, Jessica, Dalhaimer, Paul, Dalla Valle, Luisa, Dallenga, Tobias, Dalmasso, Guillaume, Damme, Markus, Dando, Ilaria, Dantuma, Nico, Darling, April, Das, Hiranmoy, Dasarathy, Srinivasan, Dasari, Santosh, Dash, Srikanta, Daumke, Oliver, Dauphinee, Adrian, Davies, Jeffrey, Dávila, Valeria, Davis, Roger, Davis, Tanja, Dayalan Naidu, Sharadha, De Amicis, Francesca, De Bosscher, Karolien, De Felice, Francesca, De Franceschi, Lucia, De Leonibus, Chiara, de Mattos Barbosa, Mayara, De Meyer, Guido, De Milito, Angelo, De Nunzio, Cosimo, De Palma, Clara, De Santi, Mauro, De Virgilio, Claudio, De Zio, Daniela, Debnath, Jayanta, DeBosch, Brian, Decuypere, Jean-Paul, Deehan, Mark, Deflorian, Gianluca, DeGregori, James, Dehay, Benjamin, Del Rio, Gabriel, Delaney, Joe, Delbridge, Lea, Delorme-Axford, Elizabeth, Delpino, M Victoria, Demarchi, Francesca, Dembitz, Vilma, Demers, Nicholas, Deng, Hongbin, Deng, Zhiqiang, Dengjel, Joern, Dent, Paul, Denton, Donna, DePamphilis, Melvin, Der, Channing, Deretic, Vojo, Descoteaux, Albert, Devis, Laura, Devkota, Sushil, Devuyst, Olivier, Dewson, Grant, Dharmasivam, Mahendiran, Dhiman, Rohan, di Bernardo, Diego, Di Cristina, Manlio, Di Domenico, Fabio, Di Fazio, Pietro, Di Fonzo, Alessio, Di Guardo, Giovanni, Di Guglielmo, Gianni, Di Leo, Luca, Di Malta, Chiara, Di Nardo, Alessia, Di Rienzo, Martina, Di Sano, 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Eissa, N Tony, Eissa, Sanaa, Ejarque, Miriam, El Andaloussi, Abdeljabar, El-Hage, Nazira, El-Naggar, Shahenda, Eleuteri, Anna Maria, El-Shafey, Eman, Elgendy, Mohamed, Eliopoulos, Aristides, Elizalde, María, Elks, Philip, Elsasser, Hans-Peter, Elsherbiny, Eslam, Emerling, Brooke, Emre, N., Eng, Christina, Engedal, Nikolai, Engelbrecht, Anna-Mart, Engelsen, Agnete, Enserink, Jorrit, Escalante, Ricardo, Esclatine, Audrey, Escobar-Henriques, Mafalda, Eskelinen, Eeva-Liisa, Espert, Lucile, Eusebio, Makandjou-Ola, Fabrias, Gemma, Fabrizi, Cinzia, Facchiano, Antonio, Facchiano, Francesco, Fadeel, Bengt, Fader, Claudio, Faesen, Alex, Fairlie, W Douglas, Falcó, Alberto, Falkenburger, Bjorn, Fan, Daping, Fan, Jie, Fan, Yanbo, Fang, Evandro, Fang, Yanshan, Fang, Yognqi, Fanto, Manolis, Farfel-Becker, Tamar, Faure, Mathias, Fazeli, Gholamreza, Fedele, Anthony, Feldman, Arthur, Feng, Du, Feng, Jiachun, Feng, Lifeng, Feng, Yibin, Feng, Yuchen, Feng, Wei, Fenz Araujo, Thais, Ferguson, Thomas, Fernández, Álvaro, Fernandez-Checa, Jose, Fernández-Veledo, Sonia, Fernie, Alisdair, Ferrante, Anthony, Ferraresi, Alessandra, Ferrari, Merari, Ferreira, Julio, Ferro-Novick, Susan, Figueras, Antonio, Filadi, Riccardo, Filigheddu, Nicoletta, Filippi-Chiela, Eduardo, Filomeni, Giuseppe, Fimia, Gian Maria, Fineschi, Vittorio, Finetti, Francesca, Finkbeiner, Steven, Fisher, Edward, Fisher, Paul, Flamigni, Flavio, Fliesler, Steven, Flo, Trude, Florance, Ida, Florey, Oliver, Florio, Tullio, Fodor, Erika, Follo, Carlo, Fon, Edward, Forlino, Antonella, Fornai, Francesco, Fortini, Paola, Fracassi, Anna, Fraldi, Alessandro, Franco, Brunella, Franco, Rodrigo, Franconi, Flavia, Frankel, Lisa, Friedman, Scott, Fröhlich, Leopold, Frühbeck, Gema, Fuentes, Jose, Fujiki, Yukio, Fujita, Naonobu, Fujiwara, Yuuki, Fukuda, Mitsunori, Fulda, Simone, Furic, Luc, Furuya, Norihiko, Fusco, Carmela, Gack, Michaela, Gaffke, Lidia, Galadari, Sehamuddin, Galasso, Alessia, Galindo, Maria, Gallolu Kankanamalage, Sachith, Galluzzi, Lorenzo, Galy, Vincent, Gammoh, Noor, Gan, Boyi, Ganley, Ian, Gao, Feng, Gao, Hui, Gao, Minghui, Gao, Ping, Gao, Shou-Jiang, Gao, Wentao, Gao, Xiaobo, Garcera, Ana, Garcia, Maria Noé, Garcia, Verónica, García-del Portillo, Francisco, Garcia-Escudero, Vega, Garcia-Garcia, Aracely, Garcia-Macia, Marina, García-Moreno, Diana, Garcia-Ruiz, Carmen, García-Sanz, Patricia, Garg, Abhishek, Gargini, Ricardo, Garofalo, Tina, Garry, Robert, Gassen, Nils, Gatica, Damian, Ge, Liang, Ge, Wanzhong, Geiss-Friedlander, Ruth, Gelfi, Cecilia, Genschik, Pascal, Gentle, Ian, Gerbino, Valeria, Gerhardt, Christoph, Germain, Kyla, Germain, Marc, Gewirtz, David, Ghasemipour Afshar, Elham, Ghavami, Saeid, Ghigo, Alessandra, Ghosh, Manosij, Giamas, Georgios, Giampietri, Claudia, Giatromanolaki, Alexandra, Gibson, Gary, Gibson, Spencer, Ginet, Vanessa, Giniger, Edward, Giorgi, Carlotta, Girao, Henrique, Girardin, Stephen, Giridharan, Mridhula, Giuliano, Sandy, Giulivi, Cecilia, Giuriato, Sylvie, Giustiniani, Julien, Gluschko, Alexander, Goder, Veit, Goginashvili, Alexander, Golab, Jakub, Goldstone, David, Golebiewska, Anna, Gomes, Luciana, Gomez, Rodrigo, Gómez-Sánchez, Rubén, Gomez-Puerto, Maria Catalina, Gomez-Sintes, Raquel, Gong, Qingqiu, Goni, Felix, González-Gallego, Javier, Gonzalez-Hernandez, Tomas, Gonzalez-Polo, Rosa, Gonzalez-Reyes, Jose, González-Rodríguez, Patricia, Goping, Ing Swie, Gorbatyuk, Marina, Gorbunov, Nikolai, Görgülü, Kıvanç, Gorojod, Roxana, Gorski, Sharon, Goruppi, Sandro, Gotor, Cecilia, Gottlieb, Roberta, Gozes, Illana, Gozuacik, Devrim, Graef, Martin, Gräler, Markus, Granatiero, Veronica, Grasso, Daniel, Gray, Joshua, Green, Douglas, Greenhough, Alexander, Gregory, Stephen, Griffin, Edward, Grinstaff, Mark, Gros, Frederic, Grose, Charles, Gross, Angelina, Gruber, Florian, Grumati, Paolo, Grune, Tilman, Gu, Xueyan, Guan, Jun-Lin, Guardia, Carlos, Guda, Kishore, Guerra, Flora, Guerri, Consuelo, Guha, Prasun, Guillén, Carlos, Gujar, Shashi, 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Elena, Uchiyama, Yasuo, Ugun-Klusek, Aslihan, Uhlig, Holm, Ułamek-Kozioł, Marzena, Ulasov, Ilya, Umekawa, Midori, Ungermann, Christian, Unno, Rei, Urbe, Sylvie, Uribe-Carretero, Elisabet, Üstün, Suayib, Uversky, Vladimir, Vaccari, Thomas, Vaccaro, Maria, Vahsen, Björn, Vakifahmetoglu-Norberg, Helin, Valdor, Rut, Valente, Maria, Valko, Ayelén, Vallee, Richard, Valverde, Angela, Van Den Berghe, Greet, van der Veen, Stijn, Van Kaer, Luc, van Loosdregt, Jorg, van Wijk, Sjoerd, Vandenberghe, Wim, Vanhorebeek, Ilse, Vannier-Santos, Marcos, Vannini, Nicola, Vanrell, M Cristina, Vantaggiato, Chiara, Varano, Gabriele, Varela-Nieto, Isabel, Varga, Máté, Vasconcelos, M Helena, Vats, Somya, Vavvas, Demetrios, Vega-Naredo, Ignacio, Vega-Rubin-de-Celis, Silvia, Velasco, Guillermo, Velázquez, Ariadna, Vellai, Tibor, Vellenga, Edo, Velotti, Francesca, Verdier, Mireille, Verginis, Panayotis, Vergne, Isabelle, Verkade, Paul, Verma, Manish, Verstreken, Patrik, Vervliet, Tim, Vervoorts, Jörg, Vessoni, Alexandre, Victor, Victor, Vidal, Michel, Vidoni, Chiara, Vieira, Otilia, Vierstra, Richard, Viganó, Sonia, Vihinen, Helena, Vijayan, Vinoy, Vila, Miquel, Vilar, Marçal, Villalba, José, Villalobo, Antonio, Villarejo-Zori, Beatriz, Villarroya, Francesc, Villarroya, Joan, Vincent, Olivier, Vindis, Cecile, Viret, Christophe, Viscomi, Maria Teresa, Visnjic, Dora, Vitale, Ilio, Vocadlo, David, Voitsekhovskaja, Olga, Volonté, Cinzia, Volta, Mattia, Vomero, Marta, Von Haefen, Clarissa, Vooijs, Marc, Voos, Wolfgang, Vucicevic, Ljubica, Wade-Martins, Richard, Waguri, Satoshi, Waite, Kenrick, Wakatsuki, Shuji, Walker, David, Walker, Mark, Walker, Simon, Walter, Jochen, Wandosell, Francisco, Wang, Bo, Wang, Chao-Yung, Wang, Chen, Wang, Chenran, Wang, Chenwei, Wang, Cun-Yu, Wang, Dong, Wang, Fangyang, Wang, Feng, Wang, Fengming, Wang, Guansong, Wang, Han, Wang, Hao, Wang, Hexiang, Wang, Hong-Gang, Wang, Jianrong, Wang, Jigang, Wang, Jiou, Wang, Jundong, Wang, Kui, Wang, Lianrong, Wang, Liming, Wang, Maggie Haitian, Wang, Meiqing, Wang, Nanbu, Wang, PengWei, Wang, PeiPei, Wang, Ping, Wang, Qing Jun, Wang, Qing, Wang, Qing Kenneth, Wang, Qiong, Wang, Wen-Tao, Wang, Wuyang, Wang, Xinnan, Wang, Xuejun, Wang, Yan, Wang, Yanchang, Wang, Yanzhuang, Wang, Yen-Yun, Wang, Yihua, Wang, Yipeng, Wang, Yu, wang, yuqi, Wang, Zhe, Wang, Zhenyu, Wang, Zhouguang, Warnes, Gary, Warnsmann, Verena, Watada, Hirotaka, Watanabe, Eizo, Watchon, Maxinne, Wawrzyńska, Anna, Weaver, Timothy, Wegrzyn, Grzegorz, Wehman, Ann, Wei, Huafeng, Wei, Lei, Wei, Taotao, Wei, Yongjie, Weiergräber, Oliver, Weihl, Conrad, Weindl, Günther, Weiskirchen, Ralf, Wells, Alan, Wen, Runxia, Wen, Xin, Werner, Antonia, Weykopf, Beatrice, Wheatley, Sally, Whitton, J Lindsay, Whitworth, Alexander, Wiktorska, Katarzyna, Wildenberg, Manon, Wileman, Tom, Wilkinson, Simon, Willbold, Dieter, Williams, Brett, Williams, Robin, Williams, Roger, Williamson, Peter, Wilson, Richard, Winner, Beate, Winsor, Nathaniel, Witkin, Steven, Wodrich, Harald, Woehlbier, Ute, Wollert, Thomas, Wong, Esther, Wong, Jack Ho, Wong, Richard, Wong, Vincent Kam Wai, Wong, W Wei-Lynn, Wu, An-Guo, Wu, Chengbiao, Wu, Jian, Wu, Junfang, Wu, Kenneth, Wu, Min, Wu, Shan-Ying, Wu, Shengzhou, Wu, Shu-Yan, Wu, Shufang, Wu, William, Wu, Xiaohong, Wu, Xiaoqing, Wu, Yao-Wen, Wu, Yihua, Xavier, Ramnik, Xia, Hongguang, Xia, Lixin, Xia, Zhengyuan, Xiang, Ge, Xiang, Jin, Xiang, Mingliang, Xiang, Wei, Xiao, Bin, Xiao, Guozhi, Xiao, Hengyi, Xiao, Hong-tao, Xiao, Jian, Xiao, Lan, Xiao, Shi, Xiao, Yin, Xie, Baoming, Xie, Chuan-Ming, Xie, Min, Xie, Yuxiang, Xie, Zhiping, Xie, Zhonglin, Xilouri, Maria, Xu, Congfeng, Xu, En, Xu, Haoxing, Xu, Jing, Xu, Jinrong, Xu, Liang, Xu, Wen Wen, Xu, Xiulong, Xue, Yu, Yakhine-Diop, Sokhna, Yamaguchi, Masamitsu, Yamaguchi, Osamu, Yamamoto, Ai, Yamashina, Shunhei, Yan, Shengmin, Yan, Shian-Jang, Yan, Zhen, Yanagi, Yasuo, Yang, Chuanbin, Yang, Dun-Sheng, Yang, Huan, Yang, Huang-Tian, Yang, Hui, Yang, Jin-Ming, Yang, Jing, Yang, Jingyu, Yang, Ling, Yang, Liu, Yang, Ming, Yang, Pei-Ming, Yang, Qian, Yang, Seungwon, Yang, Shu, Yang, Shun-Fa, Yang, Wannian, Yang, Wei Yuan, Yang, Xiaoyong, Yang, Xuesong, Yang, Yi, Yang, Ying, Yao, Honghong, Yao, Shenggen, Yao, Xiaoqiang, Yao, Yong-Gang, Yao, Yong-Ming, Yasui, Takahiro, Yazdankhah, Meysam, Yen, Paul, Yi, Cong, Yin, Xiao-Ming, Yin, Yanhai, Yin, Zhangyuan, Yin, Ziyi, Ying, Meidan, Ying, Zheng, Yip, Calvin, Yiu, Stephanie Pei Tung, Yoo, Young, Yoshida, Kiyotsugu, Yoshii, Saori, Yoshimori, Tamotsu, Yousefi, Bahman, Yu, Boxuan, Yu, Haiyang, Yu, Jun, Yu, Li, Yu, Ming-Lung, Yu, Seong-Woon, Yu, Victor, Yu, W Haung, Yu, Zhengping, Yu, Zhou, Yuan, Junying, Yuan, Ling-Qing, Yuan, Shilin, Yuan, Shyng-Shiou, Yuan, Yanggang, Yuan, Zengqiang, Yue, Jianbo, Yue, Zhenyu, Yun, Jeanho, Yung, Raymond, Zacks, David, Zaffagnini, Gabriele, Zambelli, Vanessa, Zanella, Isabella, Zang, Qun, Zanivan, Sara, Zappavigna, Silvia, Zaragoza, Pilar, Zarbalis, Konstantinos, Zarebkohan, Amir, Zarrouk, Amira, Zeitlin, Scott, Zeng, Jialiu, Zeng, Ju-deng, Žerovnik, Eva, Zhan, Lixuan, Zhang, Bin, Zhang, Donna, Zhang, Hanlin, Zhang, Hong, Zhang, Honghe, Zhang, Huafeng, Zhang, Huaye, Zhang, Hui, Zhang, Hui-Ling, Zhang, Jianbin, Zhang, Jianhua, Zhang, Jing-Pu, Zhang, Kalin, Zhang, Leshuai, Zhang, Lin, Zhang, Lisheng, Zhang, Lu, Zhang, Luoying, Zhang, Menghuan, Zhang, Peng, Zhang, Sheng, Zhang, Wei, Zhang, Xiangnan, Zhang, Xiao-Wei, Zhang, Xiaolei, Zhang, Xiaoyan, Zhang, Xin, Zhang, Xinxin, Zhang, Xu Dong, Zhang, Yang, Zhang, Yanjin, Zhang, Yi, Zhang, Ying-Dong, Zhang, Yingmei, Zhang, Yuan-Yuan, Zhang, Yuchen, Zhang, Zhe, Zhang, Zhengguang, Zhang, Zhibing, Zhang, Zhihai, Zhang, Zhiyong, Zhang, Zili, Zhao, Haobin, Zhao, Lei, Zhao, Shuang, Zhao, Tongbiao, Zhao, Xiao-Fan, Zhao, Ying, Zhao, Yongchao, Zhao, Yongliang, Zhao, Yuting, Zheng, Guoping, Zheng, Kai, Zheng, Ling, Zheng, Shizhong, Zheng, Xi-Long, Zheng, Yi, Zheng, Zu-Guo, Zhivotovsky, Boris, Zhong, Qing, Zhou, Ao, Zhou, Ben, Zhou, Cefan, ZHOU, Gang, Zhou, Hao, Zhou, Hong, Zhou, Hongbo, Zhou, Jie, Zhou, Jing, Zhou, Jiyong, Zhou, Kailiang, Zhou, Rongjia, Zhou, Xu-jie, Zhou, Yanshuang, Zhou, Yinghong, Zhou, Yubin, Zhou, Zheng-Yu, Zhou, Zhou, Zhu, Binglin, Zhu, Changlian, Zhu, Guo-Qing, Zhu, Haining, Zhu, Hongxin, Zhu, Hua, Zhu, Wei-Guo, Zhu, Yanping, Zhu, Yushan, Zhuang, Haixia, Zhuang, Xiaohong, Zientara-Rytter, Katarzyna, Zimmermann, Christine, Ziviani, Elena, Zoladek, Teresa, Zong, Wei-Xing, Zorov, Dmitry, Zorzano, Antonio, Zou, Weiping, Zou, Zhen, Zou, Zhengzhi, Zuryn, Steven, Zwerschke, Werner, Brand-Saberi, Beate, Dong, X Charlie, Kenchappa, Chandra Shekar, Li, Zuguo, Lin, Yong, Oshima, Shigeru, Rong, Yueguang, Sluimer, Judith, Stallings, Christina, Tong, Chun-Kit, Ahmad, S. Tariq, Alim Al-Bari, M. Abdul, Bechara, Luiz R.G., Behrens, Georg M.N., Bhuiyan, Md. Shenuarin, Broaddus, V. Courtney, Buchan, J. Ross, Burón, M. Isabel, Carter, A. Brent, Chan, Matthew T.V., Choi, Augustine M.K., D’Adamo, Stefania, D’Amelio, Marcello, D’Arcangelo, Daniela, D’Lugos, Andrew, D’Orazi, Gabriella, De Meyer, Guido R.Y., Delpino, M. Victoria, Distler, Jörg H.W., Dixon, Ian M.C., Dobson, Renwick C.J., 2nd Dorn, Gerald, Eissa, N. Tony, Engelsen, Agnete S.T., Fairlie, W. Douglas, Ferreira, Julio C.B., H.B., Ranjitha, Hanson, Phyllis I., Hejtmancik, J. Fielding, Ho, Idy H.T., Hobbs, G. Aaron, Hoet, Peter H.M., Huang, Michael L.H., Iyer, Anand Krishnan V., Johnson, Gail V.W., Joosten, Leo A.B., Karim, Md. Razaul, Kaufmann, Stefan H.E., Ko, Ben C.B., Leck, Lionel Y.W., Lima, Thania R.R., Livingston, J. Andrew, Martin, Alexandre P.J., Montes, L. Ruth, Murphy, J. Patrick, Ng, Charlene C.W., Nicolao, M. Celeste, O’Donovan, Tracey, O’Leary, Seónadh, O’Rourke, Eyleen, O’Sullivan, Mary, O’Sullivan, Timothy, Omary, M. Bishr, Pereira, Gustavo J.S., Ratnayaka, J. Arjuna, Riazuddin, S. Amer, Rouschop, Kasper M.A., Sanderson, J. Thomas, Scaglione, K. Matthew, Schapira, Anthony H.V., Scovassi, A. Ivana, St. Clair, Daret, Sunahara, Karen K.S., Symons, J. David, Triola, Gemma, van Wijk, Sjoerd J.L., Vanrell, M. Cristina, Vasconcelos, M. Helena, Whitton, J. Lindsay, Williams, Robin S.B., Wong, W. Wei-Lynn, Wu, William K.K., Yakhine-Diop, Sokhna M.S., Yu, W. Haung, Zhang, Kalin Y.B., Dong, X. Charlie, Ain Shams University [ASU], Johannes Gutenberg - Universität Mainz = Johannes Gutenberg University [JGU], Medical University Graz, Centre de Recherche des Cordeliers [CRC (UMR_S_1138 / U1138)], Institut Pasteur d'Iran, Leibniz Institute of Plant Biochemistry [IPB], The University of Texas M.D. Anderson Cancer Center [Houston], Institut de pharmacologie moléculaire et cellulaire [IPMC], Lipides - Nutrition - Cancer [Dijon - U1231] [LNC], Centre méditerranéen de médecine moléculaire [C3M], Institut de Biologie Valrose [IBV], Petites Molécules de neuroprotection, neurorégénération et remyélinisation, Signalisation Hormonale, Physiopathologie Endocrinienne et Métabolique, Institut Cochin [IC UM3 (UMR 8104 / U1016)], Institut NeuroMyoGène [INMG], Paris-Centre de Recherche Cardiovasculaire [PARCC (UMR_S 970/ U970)], Marqueurs cardiovasculaires en situation de stress [MASCOT (UMR_S_942 / U942)], Institut de Recherche sur le Cancer et le Vieillissement [IRCAN], Centre de Recherche en Cancérologie de Marseille [CRCM], Centre for Integrative Biology - CBI [Inserm U964 - CNRS UMR7104 - IGBMC], Oncogenesis, Stress, Signaling [OSS], Institut Necker Enfants-Malades [INEM - UM 111 (UMR 8253 / U1151)], Institut de Biologie Intégrative de la Cellule [I2BC], Microbes, Intestin, Inflammation et Susceptibilité de l'Hôte [M2iSH], Centre de Recherches en Cancérologie de Toulouse [CRCT], Physiopathologie et traitement des maladies du foie, Centre d’Infection et d’Immunité de Lille - INSERM U 1019 - UMR 9017 - UMR 8204 [CIIL], Institut de Génétique et de Biologie Moléculaire et Cellulaire [IGBMC], Laboratoire Bio-PeroxIL. Biochimie du peroxysome, inflammation et métabolisme lipidique [Dijon] [BIO-PEROXIL], Centre de recherche sur l'Inflammation [CRI (UMR_S_1149 / ERL_8252 / U1149)], Unité de génétique et biologie des cancers [U830], Laboratoire d'Optique et Biosciences [LOB], Institut des Maladies Métaboliques et Casdiovasculaires [UPS/Inserm U1297 - I2MC], Différenciation et communication neuronale et neuroendocrine [DC2N], Institut de Recherche en Cancérologie de Montpellier [IRCM - U1194 Inserm - UM], Centre d'Immunologie de Marseille - Luminy [CIML], Physiopathologie et imagerie des troubles neurologiques [PhIND], Laboratory of Fundamental and Applied Bioenergetics = Laboratoire de bioénergétique fondamentale et appliquée [LBFA], Imagine - Institut des maladies génétiques (IHU) [Imagine - U1163], Institut Mondor de Recherche Biomédicale [IMRB], Franco-czech Laboratory for clinical research on obesity, University of Michigan [Ann Arbor], University of Michigan System, Institut de pharmacologie moléculaire et cellulaire (IPMC), Centre National de la Recherche Scientifique (CNRS)-Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015 - 2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015 - 2019) (COMUE UCA)-Université Côte d'Azur (UCA), Lipides - Nutrition - Cancer [Dijon - U1231] (LNC), Université de Bourgogne (UB)-Institut National de la Santé et de la Recherche Médicale (INSERM)-AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement, Centre méditerranéen de médecine moléculaire (C3M), Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015 - 2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015 - 2019) (COMUE UCA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Côte d'Azur (UCA), Institut de Biologie Valrose (IBV), COMUE Université Côte d'Azur (2015 - 2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015 - 2019) (COMUE UCA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Côte d'Azur (UCA)-Centre National de la Recherche Scientifique (CNRS), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Sud - Paris 11 (UP11), Centre de Recherche des Cordeliers (CRC (UMR_S_1138 / U1138)), École pratique des hautes études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Université de Paris (UP), Université Paris-Sud - Paris 11 (UP11)-Institut National de la Santé et de la Recherche Médicale (INSERM)-AP-HP Hôpital Bicêtre (Le Kremlin-Bicêtre), Nutrition, Métabolisme, Aquaculture (NuMéA), Université de Pau et des Pays de l'Adour (UPPA)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Institut Cochin (IC UM3 (UMR 8104 / U1016)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), Institut NeuroMyoGène (INMG), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM), Paris-Centre de Recherche Cardiovasculaire (PARCC - UMR-S U970), Hôpital Européen Georges Pompidou [APHP] (HEGP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Paris (UP), Institut de Recherche sur le Cancer et le Vieillissement (IRCAN), COMUE Université Côte d'Azur (2015 - 2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015 - 2019) (COMUE UCA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Côte d'Azur (UCA), Centre des Sciences du Goût et de l'Alimentation [Dijon] (CSGA), Université de Bourgogne (UB)-AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Université Bourgogne Franche-Comté [COMUE] (UBFC), Centre de Recherche en Cancérologie de Marseille (CRCM), Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut Paoli-Calmettes, Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Aix Marseille Université (AMU), Centre for Integrative Biology - CBI (Inserm U964 - CNRS UMR7104 - IGBMC), Université de Strasbourg (UNISTRA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institute of genetics and molecular and cellular biology-Centre National de la Recherche Scientifique (CNRS), Chemistry, Oncogenesis, Stress and Signaling (COSS), Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-CRLCC Eugène Marquis (CRLCC)-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut Necker Enfants-Malades (INEM - UM 111 (UMR 8253 / U1151)), Unité de Nutrition Humaine (UNH), Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Clermont Auvergne (UCA), Institut de Biologie Intégrative de la Cellule (I2BC), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Microbes, Intestin, Inflammation et Susceptibilité de l'Hôte (M2iSH), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre de Recherche en Nutrition Humaine d'Auvergne (CRNH d'Auvergne)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Clermont Auvergne (UCA), Institut des Maladies Neurodégénératives [Bordeaux] (IMN), Université de Bordeaux (UB)-Centre National de la Recherche Scientifique (CNRS), Centre International de Recherche en Infectiologie - UMR (CIRI), École normale supérieure - Lyon (ENS Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Centre de Recherches en Cancérologie de Toulouse (CRCT), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Physiologie et Génomique des Poissons (LPGP), Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay, Centre d’Infection et d’Immunité de Lille - INSERM U 1019 - UMR 9017 - UMR 8204 (CIIL), Institut Pasteur de Lille, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille)-Centre National de la Recherche Scientifique (CNRS), Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA), Laboratoire Bio-PeroxIL. Biochimie du peroxysome, inflammation et métabolisme lipidique [Dijon] (BIO-PEROXIL), Université de Bourgogne (UB)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Bourgogne Franche-Comté [COMUE] (UBFC), Centre de recherche sur l'Inflammation (CRI (UMR_S_1149 / ERL_8252 / U1149)), Institut Jean-Pierre Bourgin (IJPB), AgroParisTech-Université Paris-Saclay-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Unité de génétique et biologie des cancers (U830), Institut Curie [Paris]-Institut National de la Santé et de la Recherche Médicale (INSERM), Laboratoire d'Optique et Biosciences (LOB), École polytechnique (X)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Institut des Maladies Métaboliques et Cardiovasculaires (I2MC), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM), Différenciation et communication neuronale et neuroendocrine (DC2N), Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut de Recherche en Cancérologie de Montpellier (IRCM - U1194 Inserm - UM), CRLCC Val d'Aurelle - Paul Lamarque-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM), Centre d'Immunologie de Marseille - Luminy (CIML), Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Physiopathologie et imagerie des troubles neurologiques (PhIND), Université de Caen Normandie (UNICAEN), Laboratory of Fundamental and Applied Bioenergetics = Laboratoire de bioénergétique fondamentale et appliquée (LBFA), Université Grenoble Alpes (UGA)-Institut National de la Santé et de la Recherche Médicale (INSERM), Epithelial biology and disease - Liliane Bettencourt Chair of Developmental Biology (Equipe Inserm U1163), Imagine - Institut des maladies génétiques (IHU) (Imagine - U1163), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Paris (UP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Paris (UP), Biomécanique cellulaire et respiratoire (BCR), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12)-Centre National de la Recherche Scientifique (CNRS), Charles University [Prague]-Institut National de la Santé et de la Recherche Médicale (INSERM), This work was supported by the National Institute of General Medical Sciences [GM131919]., Université Paris-Sud - Paris 11 (UP11)-Institut National de la Santé et de la Recherche Médicale (INSERM), Marqueurs cardiovasculaires en situation de stress (MASCOT (UMR_S_942 / U942)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Groupe Hospitalier Saint Louis - Lariboisière - Fernand Widal [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP)-Université Sorbonne Paris Nord, Université de Strasbourg (UNISTRA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Physiopathologie des Adaptations Nutritionnelles (PhAN), Université de Nantes (UN)-Institut National de la Recherche Agronomique (INRA), Département Plateforme (PF I2BC), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Institut Gustave Roussy (IGR), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO), Chinese Academy of Medical Sciences [Suzhou, Chine] (CAMS), Karolinska Institutet [Stockholm], Karolinska University Hospital [Stockholm], Department of Women's and Children's Health [Stockholm, Sweden], Centre National de la Recherche Scientifique (CNRS)-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille)-Université de Lille-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut Pasteur de Lille, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP), Université de Strasbourg (UNISTRA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-École polytechnique (X), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées, FHU OncoAge - Pathologies liées à l’âge [CHU Nice] (OncoAge), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Côte d'Azur (UCA)-Institut de Pharmacologie Moléculaire et Cellulaire [UNIV Côte d'Azur] (UPMC), Institut Universitaire du Cancer de Toulouse - Oncopole (IUCT Oncopole - UMR 1037), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-CHU Toulouse [Toulouse]-Institut National de la Santé et de la Recherche Médicale (INSERM), Life Sciences Institute [Ann Arbor, MI, USA], University of Michigan System-University of Michigan System, European Institute of Oncology IRCCS [Milan, Italy] (EIO), Ain Shams University (ASU), Johannes Gutenberg - Universität Mainz = Johannes Gutenberg University (JGU), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Université Paris Cité (UPCité), Réseau International des Instituts Pasteur (RIIP), Leibniz Institute of Plant Biochemistry (IPB), Hebrew University of Jerusalem, Université Nice Sophia Antipolis (1965 - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Centre National de la Recherche Scientifique (CNRS)-Université Côte d'Azur (UCA), Université de Bourgogne (UB)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut Agro Dijon, Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Côte d'Azur (UCA), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Côte d'Azur (UCA), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Paris-Centre de Recherche Cardiovasculaire (PARCC (UMR_S 970/ U970)), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité)-Université Sorbonne Paris Nord, Aix Marseille Université (AMU)-Institut Paoli-Calmettes, Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Oncogenesis, Stress, Signaling (OSS), Institut des Maladies Métaboliques et Casdiovasculaires (UPS/Inserm U1297 - I2MC), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Grenoble Alpes (UGA), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité), Institut Mondor de Recherche Biomédicale (IMRB), Institut National de la Santé et de la Recherche Médicale (INSERM)-IFR10-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), Charles University [Prague] (CU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Klionsky, D. 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G., Puertollano, R., Puglielli, L., Pulinilkunnil, T., Puri, D., Puri, R., Puyal, J., Qi, X., Qi, Y., Qian, W., Qiang, L., Qiu, Y., Quadrilatero, J., Quarleri, J., Raben, N., Rabinowich, H., Ragona, D., Ragusa, M. J., Rahimi, N., Rahmati, M., Raia, V., Raimundo, N., Rajasekaran, N. -S., Ramachandra Rao, S., Rami, A., Ramirez-Pardo, I., Ramsden, D. B., Randow, F., Rangarajan, P. N., Ranieri, D., Rao, H., Rao, L., Rao, R., Rathore, S., Ratnayaka, J. A., Ratovitski, E. A., Ravanan, P., Ravegnini, G., Ray, S. K., Razani, B., Rebecca, V., Reggiori, F., Regnier-Vigouroux, A., Reichert, A. S., Reigada, D., Reiling, J. H., Rein, T., Reipert, S., Rekha, R. S., Ren, H., Ren, J., Ren, W., Renault, T., Renga, G., Reue, K., Rewitz, K., Ribeiro de Andrade Ramos, B., Riazuddin, S. A., Ribeiro-Rodrigues, T. M., Ricci, J. -E., Ricci, R., Riccio, V., Richardson, D. R., Rikihisa, Y., Risbud, M. V., Risueno, R. M., Ritis, K., Rizza, S., Rizzuto, R., Roberts, H. C., Roberts, L. D., Robinson, K. J., Roccheri, M. C., Rocchi, S., Rodney, G. G., Rodrigues, T., Rodrigues Silva, V. R., Rodriguez, A., Rodriguez-Barrueco, R., Rodriguez-Henche, N., Rodriguez-Rocha, H., Roelofs, J., Rogers, R. S., Rogov, V. V., Rojo, A. I., Rolka, K., Romanello, V., Romani, L., Romano, A., Romano, P. S., Romeo-Guitart, D., Romero, L. C., Romero, M., Roney, J. C., Rongo, C., Roperto, S., Rosenfeldt, M. T., Rosenstiel, P., Rosenwald, A. G., Roth, K. A., Roth, L., Roth, S., Rouschop, K. M. A., Roussel, B. D., Roux, S., Rovere-Querini, P., Roy, A., Rozieres, A., Ruano, D., Rubinsztein, D. C., Rubtsova, M. P., Ruckdeschel, K., Ruckenstuhl, C., Rudolf, E., Rudolf, R., Ruggieri, A., Ruparelia, A. A., Rusmini, P., Russell, R. R., Russo, G. L., Russo, M., Russo, R., Ryabaya, O. O., Ryan, K. M., Ryu, K. -Y., Sabater-Arcis, M., Sachdev, U., Sacher, M., Sachse, C., Sadhu, A., Sadoshima, J., Safren, N., Saftig, P., Sagona, A. 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M., Villalobo, A., Villarejo-Zori, B., Villarroya, F., Villarroya, J., Vincent, O., Vindis, C., Viret, C., Viscomi, M. T., Visnjic, D., Vitale, I., Vocadlo, D. J., Voitsekhovskaja, O. V., Volonte, C., Volta, M., Vomero, M., Von Haefen, C., Vooijs, M. A., Voos, W., Vucicevic, L., Wade-Martins, R., Waguri, S., Waite, K. A., Wakatsuki, S., Walker, D. W., Walker, M. J., Walker, S. A., Walter, J., Wandosell, F. G., Wang, B., Wang, C. -Y., Wang, C., Wang, D., Wang, F., Wang, G., Wang, H., Wang, H. -G., Wang, J., Wang, K., Wang, L., Wang, M. H., Wang, M., Wang, N., Wang, P., Wang, Q. J., Wang, Q., Wang, Q. K., Wang, Q. A., Wang, W. -T., Wang, W., Wang, X., Wang, Y., Wang, Y. -Y., Wang, Z., Warnes, G., Warnsmann, V., Watada, H., Watanabe, E., Watchon, M., Wawrzynska, A., Weaver, T. E., Wegrzyn, G., Wehman, A. M., Wei, H., Wei, L., Wei, T., Wei, Y., Weiergraber, O. H., Weihl, C. C., Weindl, G., Weiskirchen, R., Wells, A., Wen, R. H., Wen, X., Werner, A., Weykopf, B., Wheatley, S. P., Whitton, J. L., Whitworth, A. J., Wiktorska, K., Wildenberg, M. E., Wileman, T., Wilkinson, S., Willbold, D., Williams, B., Williams, R. S. B., Williams, R. L., Williamson, P. R., Wilson, R. A., Winner, B., Winsor, N. J., Witkin, S. S., Wodrich, H., Woehlbier, U., Wollert, T., Wong, E., Wong, J. H., Wong, R. W., Wong, V. K. W., Wong, W. W. -L., Wu, A. -G., Wu, C., Wu, J., Wu, K. K., Wu, M., Wu, S. -Y., Wu, S., Wu, W. K. K., Wu, X., Wu, Y. -W., Wu, Y., Xavier, R. J., Xia, H., Xia, L., Xia, Z., Xiang, G., Xiang, J., Xiang, M., Xiang, W., Xiao, B., Xiao, G., Xiao, H., Xiao, H. -T., Xiao, J., Xiao, L., Xiao, S., Xiao, Y., Xie, B., Xie, C. -M., Xie, M., Xie, Y., Xie, Z., Xilouri, M., Xu, C., Xu, E., Xu, H., Xu, J., Xu, L., Xu, W. W., Xu, X., Xue, Y., Yakhine-Diop, S. M. S., Yamaguchi, M., Yamaguchi, O., Yamamoto, A., Yamashina, S., Yan, S., Yan, S. -J., Yan, Z., Yanagi, Y., Yang, C., Yang, D. -S., Yang, H., Yang, H. -T., Yang, J. -M., Yang, J., Yang, L., Yang, M., Yang, P. -M., Yang, Q., Yang, S., Yang, S. -F., Yang, W., Yang, W. Y., Yang, X., Yang, Y., Yao, H., Yao, S., Yao, X., Yao, Y. -G., Yao, Y. -M., Yasui, T., Yazdankhah, M., Yen, P. M., Yi, C., Yin, X. -M., Yin, Y., Yin, Z., Ying, M., Ying, Z., Yip, C. K., Yiu, S. P. T., Yoo, Y. H., Yoshida, K., Yoshii, S. R., Yoshimori, T., Yousefi, B., Yu, B., Yu, H., Yu, J., Yu, L., Yu, M. -L., Yu, S. -W., Yu, V. C., Yu, W. H., Yu, Z., Yuan, J., Yuan, L. -Q., Yuan, S., Yuan, S. -S. F., Yuan, Y., Yuan, Z., Yue, J., Yue, Z., Yun, J., Yung, R. L., Zacks, D. N., Zaffagnini, G., Zambelli, V. O., Zanella, I., Zang, Q. S., Zanivan, S., Zappavigna, S., Zaragoza, P., Zarbalis, K. S., Zarebkohan, A., Zarrouk, A., Zeitlin, S. O., Zeng, J., Zeng, J. -D., Zerovnik, E., Zhan, L., Zhang, B., Zhang, D. D., Zhang, H., Zhang, H. -L., Zhang, J., Zhang, J. -P., Zhang, K. Y. B., Zhang, L. W., Zhang, L., Zhang, M., Zhang, P., Zhang, S., Zhang, W., Zhang, X., Zhang, X. -W., Zhang, X. D., Zhang, Y., Zhang, Y. -D., Zhang, Y. -Y., Zhang, Z., Zhao, H., Zhao, L., Zhao, S., Zhao, T., Zhao, X. -F., Zhao, Y., Zheng, G., Zheng, K., Zheng, L., Zheng, S., Zheng, X. -L., Zheng, Y., Zheng, Z. -G., Zhivotovsky, B., Zhong, Q., Zhou, A., Zhou, B., Zhou, C., Zhou, G., Zhou, H., Zhou, J., Zhou, K., Zhou, R., Zhou, X. -J., Zhou, Y., Zhou, Z. -Y., Zhou, Z., Zhu, B., Zhu, C., Zhu, G. -Q., Zhu, H., Zhu, W. -G., Zhu, Y., Zhuang, H., Zhuang, X., Zientara-Rytter, K., Zimmermann, C. M., Ziviani, E., Zoladek, T., Zong, W. -X., Zorov, D. B., Zorzano, A., Zou, W., Zou, Z., Zuryn, S., Zwerschke, W., Brand-Saberi, B., Dong, X. C., Kenchappa, C. S., Lin, Y., Oshima, S., Rong, Y., Sluimer, J. C., Stallings, C. L., Tong, C. -K., and Centre National de la Recherche Scientifique (CNRS)
Subjects: 0301 basic medicine, Programmed cell death, Settore BIO/06, Autophagosome, Autolysosome, [SDV]Life Sciences [q-bio], lnfectious Diseases and Global Health Radboud Institute for Molecular Life Sciences [Radboudumc 4], Autophagy-Related Proteins, Review, Computational biology, [SDV.BC]Life Sciences [q-bio]/Cellular Biology, Biology, Settore MED/04, 03 medical and health sciences, stress, Chaperone-mediated autophagy, ddc:570, Autophagy, LC3, Animals, Humans, cancer, Settore BIO/10, flux, lysosome, macroautophagy, neurodegeneration, phagophore, vacuole, Set (psychology), Molecular Biology, 030102 biochemistry & molecular biology, business.industry, Interpretation (philosophy), Autophagosomes, Cell Biology, Multicellular organism, 030104 developmental biology, Knowledge base, Biological Assay, Lysosomes, business, Biomarkers, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Abstract: Contains fulltext : 232759.pdf (Publisher’s version ) (Closed access) In 2008, we published the first set of guidelines for standardizing research in autophagy. Since then, this topic has received increasing attention, and many scientists have entered the field. Our knowledge base and relevant new technologies have also been expanding. Thus, it is important to formulate on a regular basis updated guidelines for monitoring autophagy in different organisms. Despite numerous reviews, there continues to be confusion regarding acceptable methods to evaluate autophagy, especially in multicellular eukaryotes. Here, we present a set of guidelines for investigators to select and interpret methods to examine autophagy and related processes, and for reviewers to provide realistic and reasonable critiques of reports that are focused on these processes. These guidelines are not meant to be a dogmatic set of rules, because the appropriateness of any assay largely depends on the question being asked and the system being used. Moreover, no individual assay is perfect for every situation, calling for the use of multiple techniques to properly monitor autophagy in each experimental setting. Finally, several core components of the autophagy machinery have been implicated in distinct autophagic processes (canonical and noncanonical autophagy), implying that genetic approaches to block autophagy should rely on targeting two or more autophagy-related genes that ideally participate in distinct steps of the pathway. Along similar lines, because multiple proteins involved in autophagy also regulate other cellular pathways including apoptosis, not all of them can be used as a specific marker for bona fide autophagic responses. Here, we critically discuss current methods of assessing autophagy and the information they can, or cannot, provide. Our ultimate goal is to encourage intellectual and technical innovation in the field.
Published: 2021
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45. Ribotoxin-like proteins from Boletus edulis: structural properties, cytotoxicity and in vitro digestibility

Author: Elio Pizzo, Rosita Russo, Rosanna Culurciello, Sara Ragucci, Mariangela Valletta, Antimo Di Maro, Nicola Landi, Paolo V. Pedone, Landi, N., Ragucci, S., Culurciello, R., Russo, R., Valletta, M., Pedone, P. V., Pizzo, E., and Di Maro, A.
Subjects: Protein Conformation, Proteolysis, Porcini, Fungal Protein, 01 natural sciences, Analytical Chemistry, Ribotoxin-like protein, Fungal Proteins, Ribonuclease, 0404 agricultural biotechnology, medicine, Humans, Ingestion, Food science, Mushroom poisoning, Ageritin, Toxins, Biological, chemistry.chemical_classification, Edible mushroom, Food poisoning, biology, medicine.diagnostic_test, business.industry, Chemistry, Basidiomycota, 010401 analytical chemistry, 04 agricultural and veterinary sciences, General Medicine, Food safety, biology.organism_classification, medicine.disease, 040401 food science, 0104 chemical sciences, Ribotoxin-like proteins, Protein purification, Enzyme, Boletus edulis, Toxicity, business, Food Science, Human
Abstract: Porcini are edible mushrooms widely used in cooking due to their extraordinary taste. Despite this, cases of food poisoning have been reported in the recent literature also for ingestion of porcini. Here, we report the isolation from Boletus edulis fruiting bodies of two novel ribotoxin-like proteins (RL-Ps), enzymes already studied in other organisms for their toxicity. These RL-Ps, named Edulitin 1 (16-kDa) and Edulitin 2 (14-kDa), show peculiar structural and enzymatic differences, which probably reflect their different bio-activities and a dose/time dependent toxicity (Edulitin 2) on normal and tumoral human cells. Particularly interesting is the resistance to proteolysis of Edulitin 2, for which it was observed that its toxicity was abolished only after heat treatment (90 °C) followed by proteolysis. As mushroom poisoning is a serious food safety issue, data here presented confirm the existence of toxins also in porcini and the importance of a proper cooking before their consumption.
Published: 2021

46. Institutional Investors’ Representativeness and Earnings Management: Evidence from a High Ownership Concentration Context

Author: Michele Pizzo, Nicola Moscariello, Pietro Fera, Giorgio Ricciardi, AA.VV., E. Vieira, M. Madaleno, G. Azevedo, Fera, Pietro, Moscariello, Nicola, Pizzo, Michele, and Ricciardi, Giorgio
Subjects: 050208 finance, Earnings management, business.industry, 0502 economics and business, 05 social sciences, Institutional investor, Context (language use), Accounting, 050201 accounting, Business, Representativeness heuristic
Abstract: In contexts characterized by high ownership concentration, institutional investors may lose their monitoring role and might not be effective in constraining earnings management. So, this study investigates whether directors appointed by institutional shareholders are more effective in inhibiting earnings management for companies with a high ownership concentration, rather than the mere presence of institutional investors. Based on a sample of Italian listed companies, findings suggest a negative relationship between minority directors appointed by institutional shareholders and abnormal accruals, while no relationship is found between the latter and the mere presence of institutional investors. Moreover, results also highlight that the difference between strategic and no strategic institutional investors does not count in a context characterized by high ownership concentration. Overall, this study suggests that institutional investors, regardless of their characteristics, are more effective in constraining earnings management when they can count on an agent on the board of directors.
Published: 2021

47. Ictal connectivity changes induced by pulvinar stimulation correlate with improvement of awareness

Author: Romain Carron, Samuel Medina Villalon, Fabrice Bartolomei, Barbora Deutschová, Francesca Pizzo, Bernard Giusiano, Christian Bénar, Masaryk University [Brno] (MUNI), Institut de Neurosciences des Systèmes (INS), Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Hôpital de la Timone [CHU - APHM] (TIMONE), and Pizzo, Francesca
Subjects: 0303 health sciences, business.industry, General Neuroscience, Biophysics, Stimulation, lcsh:RC321-571, 03 medical and health sciences, 0302 clinical medicine, Text mining, Medicine, Ictal, [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], [SDV.NEU] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], Neurology (clinical), business, Neuroscience, lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry, 030217 neurology & neurosurgery, 030304 developmental biology
Abstract: International audience; In patients with epilepsy, alteration of awareness (AOA) during seizures is a disabling feature that can potentially lead to serious consequences such as falls and injuries. Regarding the neural mechanisms underlying AOA in focal seizures, some hypotheses have been put forward. In temporal lobe epilepsy, AOA has been related to the extension of the discharge to subcortical structures and to subsequent widespread inhibition (Blumenfeld and Taylor, 2003) or disturbed synchrony process (Bartolomei and Naccache, 2011) of the fronto-parietal association cortices. Thalamic stimulation was shown to be effective in reducing AOA (Gummadavelli et al., 2015). The medial pulvinar (PuM) is a thalamic nucleus often involved in focal seizures in different type of epilepsy (Pizzo et al., 2020). In a recent work (Filipescu et al., 2019), we observed that high frequency stimulation of the PuM during temporal lobe seizures could lead to improvement of awareness. Data from intracranial recordings in epileptic patients suggested that transition between conscious and non-conscious states during seizures was due to an excessive synchrony between the thalamus and associative cortices (Arthuis et al., 2009; Bartolomei and Naccache, 2011).
Published: 2021
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48. SARS-CoV-2 Infection in Healthcare Professionals and General Population During 'First Wave' of COVID-19 Pandemic: A Cross-Sectional Study Conducted in Sicily, Italy

Author: Claudio Costantino, Emanuele Cannizzaro, Maria Gabriella Verso, Fabio Tramuto, Carmelo Massimo Maida, Guido Lacca, Davide Alba, Livia Cimino, Arianna Conforto, Luigi Cirrincione, Giorgio Graziano, Sara Palmeri, Stefano Pizzo, Vincenzo Restivo, Alessandra Casuccio, Francesco Vitale, Walter Mazzucco, Costantino C., Cannizzaro E., Verso M.G., Tramuto F., Maida C.M., Lacca G., Alba D., Cimino L., Conforto A., Cirrincione L., Graziano G., Palmeri S., Pizzo S., Restivo V., Casuccio A., Vitale F., and Mazzucco W.
Subjects: Cross-sectional study, Family support, Health Personnel, Population, Context (language use), 03 medical and health sciences, 0302 clinical medicine, healthcare worker, traffic control building, Environmental health, Health care, Pandemic, Medicine, Humans, 030212 general & internal medicine, education, Personal protective equipment, Sicily, Pandemics, Cross-Sectional Studie, 0303 health sciences, education.field_of_study, 030306 microbiology, business.industry, SARS-CoV-2, healthcare workers, Incidence (epidemiology), SARS-CoV-2 infection, Public Health, Environmental and Occupational Health, virus diseases, COVID-19, psycho-physical support, Brief Research Report, in, influenza vaccination, fluenza vaccination, Cross-Sectional Studies, personal protective equipment, Public Health, Public aspects of medicine, RA1-1270, business, Delivery of Health Care
Abstract: On December 31, 2019, an outbreak of lower respiratory infections was documented in Wuhan caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Since the beginning, SARS-CoV-2 has caused many infections among healthcare workers (HCWs) worldwide. Aims of this study were: a. to compare the distribution among the HCWs and the general population of SARS-CoV-2 infections in Western Sicily and Italy; b. to describe the characteristics of HCWs infected with SARS-CoV-2 in the western Sicilian healthcare context during the first wave of the epidemic diffusion in Italy. Incidence and mean age of HCWs infected with SARS-CoV-2 were comparable in Western Sicily and in the whole Italian country. The 97.6% of infections occurred in HCWs operating in non-coronavirus disease 2019 (COVID-19) working environments, while an equal distribution of cases between hospital and primary care services context was documented. Nurses and healthcare assistants, followed by physicians, were the categories more frequently infected by SARS-CoV-2. The present study suggests that healthcare workers are easily infected compared to the general population but that often infection could equally occur in hospital and non-hospital settings. Safety of HCWs in counteracting the COVID-19 pandemic must be strengthened in hospital [adequate provision of personal protective equipment (PPE), optimization of human resources, implementation of closed and independent groups of HCWs, creation of traffic control building and dedicated areas in every healthcare context] and non-hospital settings (influenza vaccination, adequate psychophysical support, including refreshments during working shifts, adequate rest, and family support).
Published: 2021

49. Online analysis and prediction of the inertia in power systems with renewable power generation based on a minimum variance harmonic finite impulse response filter

Author: F. Del Pizzo, Fabio Mottola, Davide Lauria, Enrico Maria Carlini, Giorgio Maria Giannuzzi, Cosimo Pisani, Carlini, E. M., Del Pizzo, F., Giannuzzi, G. M., Lauria, D., Mottola, F., and Pisani, C.
Subjects: Finite impulse response, Computer science, business.industry, 020209 energy, media_common.quotation_subject, Integration of renewable energy source, 020208 electrical & electronic engineering, Energy Engineering and Power Technology, 02 engineering and technology, Converters, Finite-impulse-response filter, Grid, Inertia, Power (physics), Renewable energy, Electric power system, Control theory, Real-time inertia estimation, 0202 electrical engineering, electronic engineering, information engineering, Harmonic, Electrical and Electronic Engineering, business, media_common
Abstract: This paper deals with the inertia estimation of power systems in presence of significant contribution provided by renewable energy sources. The efforts to decommission conventional power plants and replace them with renewable resources could affect the robust and reliable operation of future power systems. The main issue related to the integration of renewable-based generation in the networks deals with the substitution of conventional synchronous generators connected to the grid and equipped by rotating masses, with converter-based generator which have not rotating masses, or they are decoupled by the grid due to the presence of interfacing power converters. Since the system inertia is the inherent ability of the online synchronous machines to oppose sudden changes in generation or load, the increasing share of renewable generators, such as wind and solar, the overall system inertia could decrease. This leading network operators to introduce new tools for monitoring the system inertia values, to contain them within admissible values, and to better prepare for different kinds of operational scenarios with undesired reduction of the system inertia. At this purpose, in this paper a tool for the analysis and prediction of inertia is proposed. The proposed method is based on a minimum variance harmonic finite impulse response and can consider the actual penetration of renewable energy sources. The proposed approach is tailored for online monitoring and exploits the real time measurements of relevant features of the network. The method is tested with actual data of the Italian Transmission Network and its effectiveness is studied by comparisons with some popular and well-established method of analysis and prediction.
Published: 2021

50. Optical coherence tomography angiography evaluation of peripapillary microvascular changes after rhegmatogenous retinal detachment repair

Author: Matteo Fallico, Mario Damiano Toro, Clara Patanè, Robert Rejdak, Alessandra Pizzo, Davide Scollo, Iacopo Macchi, Roberta Panebianco, Marcella Nebbioso, Maria Vadalà, Teresio Avitabile, Andrea Russo, Antonio Longo, Katarzyna Nowomiejska, Vincenza Bonfiglio, Marco Lupidi, Michele Reibaldi, Elina Ortisi, Bonfiglio, V, Ortisi, E, Nebbioso, M, Reibaldi, M, Lupidi, M, Russo, A, Fallico, M, Scollo, D, Macchi, I, Pizzo, A, Panebianco, R, Patanè, C, Vadalà, M, Toro, Md, Rejdak, R, Nowomiejska, K, Avitabile, T, and Longo, A
Subjects: Male, Retinal Ganglion Cells, genetic structures, Computed Tomography Angiography, medicine.medical_treatment, Nerve fiber layer, Visual Acuity, Vitrectomy, Eye, radial peripapillary capillary plexus, chemistry.chemical_compound, Nerve Fibers, Tomography, Retinal detachment repair, Retinal detachment, General Medicine, Middle Aged, Axial Length, Eye, medicine.anatomical_structure, Female, Tomography, Optical Coherence, Pars plana, medicine.medical_specialty, Biometry, Optic Disk, Endotamponade, retinal detachment, OCT-angiography, Radial peripapillary capillary plexus, Retinal nerve fiber layer, Aged, Cross-Sectional Studies, Humans, Retinal Detachment, Retinal Vessels, Retrospective Studies, Ophthalmology, medicine, Axial Length, Retina, business.industry, retinal nerve fiber layer, Retinal, Optical coherence tomography angiography, medicine.disease, eye diseases, chemistry, Optical Coherence, sense organs, business
Abstract: PURPOSE To evaluate the radial peripapillary capillary plexus (RPCP) vessel density (VD) and the retinal nerve fiber layer (RNFL) thickness in eyes successfully treated with pars plana vitrectomy for primary rhegmatogenous retinal detachment. METHODS In this cross-sectional multicenter clinical study, eyes with a minimum 12-month follow-up were reexamined. The RPCP VD and RNFL thickness in the rhegmatogenous retinal detachment subfields of the affected eye (study group) were compared with the corresponding areas of the healthy fellow eyes (control group). RESULTS Fifty-three eyes were included in the study. A significantly lower RPCP VD and RNFL thickness were observed in those subfields affected by rhegmatogenous retinal detachment compared with those of the control group (P < 0.001). No statistically significant differences were observed between undetached subfields in the study group and their corresponding images in the control group. In the study group, a significant correlation was found between RPCP VD and RNFL thickness in subfields with detached retina (r = 0.393, P < 0.001) and undetached retina (r = 0.321, P < 0.001). CONCLUSION Radial peripapillary capillary plexus VD changes were found in the subfields of detached retina successfully treated with pars plana vitrectomy and they correlated with RNFL thinning. These data suggest a coexistence of neuronal and microvascular damage in patients affected by rhegmatogenous retinal detachment.
Published: 2021

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