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1. Virtual Class: Distance Learning for Small and Medium Sized Enterprises in the Spanish Region of Castilla y Leon.

Author

Rodriguez, Blanca, Perez, Maria Angeles, Verdu, Maria Jesus, Navazo, Maria Agustina, Lopez, Ricardo, Mompo, Rafael, and Garcia, Joaquin

Abstract

Lifelong learning is becoming a necessity in the new Information Society where everyone, particularly small and medium sized enterprises (SMEs), must keep up with new technologies. Education and training are of the most importance in this updating. An interdisciplinary and inter-university work group called "Canalejas" (Spain) has developed a multimedia educational CD-ROM, "Basic Course on Telecommunications for Small and Medium Sized Enterprises," a client-server application which includes the "Virtual Class" distance learning environment and interactive multimedia courses on telecommunication services. This paper addresses the technical and educational issues addressed in developing a multimedia educational CD-ROM, beginning with an overview of the objectives and presentation of the work group, educating for the Information Society/lifelong learning, and new technologies for distance learning. The CD-ROM course is then described, including hardware configuration, distance learning environment, and steps in the multimedia development methodology. Two figures present the user interface. (Author/AEF)

Published
1998

3. Addressing health care needs of Colorado immigrants using a community power building approach

Author

Albright, Karen, Perez, Maria de Jesus Diaz, Trujillo, Theresa, Beascochea, Yesenia, and Sammen, Joe

Subjects
Medical care -- Utilization, Immigrants -- Health aspects, Health care disparities -- Evaluation, Business, Health care industry
Abstract

Objective: To assess and address through policy change the health-care needs of immigrant populations in Colorado. Data Sources: Primary data were collected in two Colorado communities from June 2019 through December 2020. Study Design: This work utilized a mixed-method, community power building approach to determine and meet health-care needs of immigrants, a marginalized population of mixed documentation status. Findings were then used to inform Emergency Medicaid (EM) expansion in Colorado. Data Collection: In-depth interviews were conducted in Spanish, English, and Somali with 47 immigrants in rural Morgan County in June-September 2019; findings were presented to the community for feedback in January-February 2020. In March-December 2020, 330 interviews were conducted in Spanish and English with 208 unique individuals in Morgan and Pueblo Counties by local community grassroots leaders via four rounds of a novel phone tree outreach method. Interviewees were identified through snowball sampling and direct outreach among individuals seeking immediate relief (i.e., food assistance). Principal Findings: Interviewees reported numerous barriers to health-care access, including discrimination and limited service hours and transportation options. Data also revealed a clear health insurance coverage gap among undocumented immigrants. These data were then presented to Colorado's Department of Health-Care Policy and Financing, ultimately contributing to securing EM expansion to this population to include COVID treatment, including respiratory therapies and outpatient follow-up appointments. Data-informed continued implementation advocacy to ensure the effectiveness of EM program expansion. Conclusions: Immigrants are particularly marginalized by the health-care system. Rapid data collection grounded in a community power-building approach produced data that directly informed state policy and an increased power base. This approach enables direct connection to immediate 'downstream' needs in communities while simultaneously building collective systemic 'upstream' analysis and capacity of community members and laying pathways to translation and implementation of research into policy. KEYWORDS Colorado, health services accessibility, immigrants, insurance coverage, Medicaid, policy What is known on this topic * Immigrants, particularly non-citizens or those without legal status, experience significant barriers to access to health care. * This population is often difficult to access through conventional research methods. What this study adds * Barriers to health care among rural immigrants include lack of insurance, high and additional costs of services, lack of timely access to services, long wait times, lack of transportation, and limited service hours. * Changes to the health-care system that would improve the experience of rural immigrants include more affordable insurance options; additional health-care facilities and providers, including specialists; better trained and/or bilingual staff; and improved information about the disease, payment options, and access. * Engaging immigrant populations using a community power building model is an effective method of identifying and addressing social and structural barriers to health care and building a power base for a community organization; in Colorado, it led to improved access to insurance through Emergency Medicaid and improved access to COVID-related information., 1 | INTRODUCTION Nearly 44 million people living in the United States, or 13.5% of the total population, are immigrants. (1) Overall, immigrants tend to be healthier than comparable groups [...]

Published
2022
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4. Increased Colonic Epithelial Permeability and Mucosal Eosinophilia in Ulcerative Colitis in Remission Compared With Irritable Bowel Syndrome and Health

Author

Katinios, Georgios, Casado Bedmar, María Teresa, Walter, Susanna A., Vicario Perez, Maria, González Castro, Ana Maria, Bednarska, Olga, Söderholm, Johan D., Hjortswang, Henrik, Keita, Åsa V, and Universitat Autònoma de Barcelona

Subjects
Adult, Male, medicine.medical_specialty, Colon, Biopsy, mast cells, Gastroenterology and Hepatology, Epithelial permeability, Intestinal permeability, Gastroenterology, Permeability, Young Adult, Human placental lactogen, Internal medicine, Eosinophilia, Gastroenterologi, medicine, Humans, Immunology and Allergy, Intestinal Mucosa, Irritable bowel syndrome, AcademicSubjects/MED00260, ulcerative colitis, irritable bowel syndrome, intestinal permeability, business.industry, Remission Induction, Mucous membrane, Middle Aged, medicine.disease, Ulcerative colitis, Mucosal eosinophilia, Eosinophils, Editor's Choice, medicine.anatomical_structure, Permeability (electromagnetism), Case-Control Studies, Mast cells, eosinophils, Colitis, Ulcerative, Female, Leading Off, business
Abstract

Background Barrier dysfunction is recognized as a pathogenic factor in ulcerative colitis (UC) and irritable bowel syndrome (IBS), but it is unclear to what extent the factors related to barrier dysfunction are disease-specific. The aim of this study was to compare these aspects in UC patients in remission, IBS patients, and healthy controls (HCs). Methods Colonic biopsies were collected from 13 patients with UC in remission, 15 patients with IBS-mixed, and 15 HCs. Ulcerative colitis patients had recently been treated for relapse, and biopsies were taken from earlier inflamed areas. Biopsies were mounted in Ussing chambers for measurements of intestinal paracellular permeability to 51chromium (Cr)-ethylenediaminetetraacetic acid (EDTA). In addition, biopsies were analyzed for mast cells and eosinophils by histological procedures, and plasma tumor necrosis factor (TNF)-α was assessed by ELISA. Results Ussing chamber experiments revealed an increased 51Cr-EDTA permeability in UC and IBS (P < 0.05). The 51Cr-EDTA permeability was higher in UC compared with IBS (P < 0.005). There were increased numbers of mucosal mast cells and eosinophils in UC and IBS and more eosinophils in UC compared with IBS (P < 0.05). Also, increased extracellular granule content was found in UC compared with HCs (P < 0.05). The 51Cr-EDTA permeability correlated significantly with eosinophils in all groups. Plasma TNF-α concentration was higher in UC compared with IBS and HCs (P < 0.0005). Conclusions Results indicate a more permeable intestinal epithelium in inactive UC and IBS compared with HCs. Ulcerative colitis patients, even during remission, demonstrate a leakier barrier compared with IBS. Both eosinophil numbers and activation state might be involved in the increased barrier function seen in UC patients in remission., Main results from this study indicate a more permeable intestinal epithelium in inactive UC and IBS compared with HCs. Moreover, UC patients, even during remission, demonstrate a leakier barrier compared with IBS, which seems to be associated with eosinophils.

Published
2020
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7. A linear optimization problem to derive relative weights using an interval judgement matrix

Author

Conde, Eduardo and Perez, MariA De La Paz Rivera

Subjects
Mathematical optimization -- Analysis, Business, Business, general, Business, international
Abstract

To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.ejor.2009.03.029 Byline: Eduardo Conde (a), Maria de la Paz Rivera Perez (b) Keywords: Decision analysis; Multi-objective optimization Abstract: In this paper, we propose a new Decision Making model, enabling to assess a finite number of alternatives according to a set of bounds on the preference ratios for the pairwise comparisons between alternatives, that is, an 'interval judgement matrix'. In the case in which these bounds cannot be achieved by any assessment vector, we analyze the problem of determining of an efficient or Pareto-optimal solution from a multi-objective optimization problem. This multi-objective formulation seeks for assessment vectors that are near to simultaneously fulfil all the bound requirements imposed by the interval judgement matrix. Our new model introduces a linear optimization problem in order to define a consistency index for the interval matrix. By solving this optimization problem it can be associated a weakly efficient assessment vector to the consistency index in those cases in which the bound requirements are infeasible. Otherwise, this assessment vector fulfils all the bound requirements and has geometrical properties that make it appropriate as a representative assessment vector of the set of feasible weights. Author Affiliation: (a) Departamento de Estadistica e Investigacion Operativa, Facultad de Matematicas, Universidad de Sevilla, Campus Universitario de Reina Mercedes, 41012 Sevilla, Spain (b) Departamento de Economia y Metodos Cuantitativos, Universidad Pablo de Olavide, Ctra. de Utrera, Km. 1- 41013 Sevilla, Spain Article History: Received 5 July 2007; Accepted 15 March 2009

Published
2010

8. Effects of competitive e-learning tools on higher education students: a case study

Author

Regueras, Luisa M., Verdu, Elena, Munoz, Maria F., Perez, Maria A., de Castro, Juan P., and Verdu, Maria Jesus

Subjects
Online education -- Methods, Communication -- Educational aspects, Information technology -- Educational aspects, Information technology, Business, Education, Electronics, Electronics and electrical industries
Abstract

Over the last few years, most of the attempts to introduce active learning methodologies in the classroom have made use of Information and Communication Technology (ICT). Many of these efforts have been directed to collaborative scenarios used in remote, blended or face-to-face experiences, in order to take advantage of the flexibility provided by ICT. However competitive learning could also have some positive effects on the success of the learning process, to be added to those of collaborative virtual environments. This paper explores the effects of competitive learning on the satisfaction and the academic achievement of telecommunications students. A tool for active and competitive learning (called QUEST) has been used in the 'Communications Networks' undergraduate course. Significant results on the use of competitive e-learning tools in university students' outcomes and satisfaction are presented. Index Terms--Active learning, collaborative learning, competitive learning, e-learning, higher education, teaching/learning strategies.

Published
2009

9. Introduction to the European Society of Biomechanics

Author

Perez Maria Angeles, ESB-Council, cristofolini luca, Markus Heller, Harry van Lenthe, Sara Checa, David Mitton, Mark Thompson, Dieter Pahr, Enrico Dall'Ara, Perez Maria Angele, ESB-Council, cristofolini luca, Markus Heller, Harry van Lenthe, Sara Checa, David Mitton, Mark Thompson, Dieter Pahr, and Enrico Dall'Ara

Subjects
Engineering, Structural Biology, business.industry, Commentary, Biophysics, Membrane biology, Engineering ethics, business, Molecular Biology, European Society of Biomechanics
Abstract

The European Society of Biomechanics (ESB; esbiomech. org) was founded at a meeting of 20 scientists from 11 countries in Brussels on May 21, 1976. Biomechanics was defined as “the study of forces acting on and generated within a body and of the effects of these forces on the tissues, fluids or materials used for diagnosis, treatment or research purposes.” The primary goal of the ESB was formulated as “to encourage, foster, promote and develop research, progress and information concerning the science of Biomechanics.”

Published
2019

10. Trabecular bone score and insulin resistance in type 2 diabetes mellitus

Author

Beatriz Garcia Fontana, Laguna Mª del Carmen Serrano, Perez Maria Dolores Aviles, Torres Manuel Muñoz, Sheila Gonzalez Salvatierra, García Diego Becerra, and Ponce Maria Hayon

Subjects
medicine.medical_specialty, Endocrinology, Trabecular bone score, Insulin resistance, business.industry, Internal medicine, medicine, Type 2 Diabetes Mellitus, business, medicine.disease
Published
2020
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11. Height and body-mass index trajectories of school-aged children and adolescents from 1985 to 2019 in 200 countries and territories: a pooled analysis of 2181 population-based studies with 65 million participants

Author

Rodriguez-Martinez, Andrea, Zhou, Bin, Sophiea, Marisa K, Bentham, James, Paciorek, Christopher J, Iurilli, Maria LC, Carrillo-Larco, Rodrigo M, Bennett, James E, Di Cesare, Mariachiara, Taddei, Cristina, Bixby, Honor, Stevens, Gretchen A, Riley, Leanne M, Cowan, Melanie J, Savin, Stefan, Danaei, Goodarz, Chirita-Emandi, Adela, Kengne, Andre P, Khang, Young-Ho, Laxmaiah, Avula, Malekzadeh, Reza, Miranda, J Jaime, Moon, Jin Soo, Popovic, Stevo R, Sorensen, Thorkild IA, Soric, Maroje, Starc, Gregor, Zainuddin, Ahmad A, Gregg, Edward W, Bhutta, Zulfiqar A, Black, Robert, Ezzati, Majid, Abarca-Gomez, Leandra, Abdeen, Ziad A, Abdrakhmanova, Shynar, Ghaffar, Suhaila Abdul, Rahim, Hanan F Abdul, Abu-Rmeileh, Niveen M, Garba, Jamila Abubakar, Acosta-Cazares, Benjamin, Adams, Robert J, Aekplakorn, Wichai, Afsana, Kaosar, Afzal, Shoaib, Agdeppa, Imelda A, Aghazadeh-Attari, Javad, Aguilar-Salinas, Carlos A, Agyemang, Charles, Ahmad, Mohamad Hasnan, Ahmad, Noor Ani, Ahmadi, Ali, Ahmadi, Naser, Ahmed, Soheir H, Ahrens, Wolfgang, Aitmurzaeva, Gulmira, Ajlouni, Kamel, Al-Hazzaa, Hazzaa M, Al-Othman, Amani Rashed, Al-Raddadi, Rajaa, Alarouj, Monira, AlBuhairan, Fadia, AlDhukair, Shahla, Ali, Mohamed M, Alkandari, Abdullah, Alkerwi, Ala'a, Allin, Kristine, Alvarez-Pedrerol, Mar, Aly, Eman, Amarapurkar, Deepak N, Amiri, Parisa, Amougou, Norbert, Amouyel, Philippe, Andersen, Lars Bo, Anderssen, Sigmund A, Angquist, Lars, Anjana, Ranjit Mohan, Ansari-Moghaddam, Alireza, Aounallah-Skhiri, Hajer, Araujo, Joana, Ariansen, Inger, Aris, Tahir, Arku, Raphael E, Arlappa, Nimmathota, Aryal, Krishna K, Aspelund, Thor, Assah, Felix K, Assuncao, Maria Cecilia F, Aung, May Soe, Auvinen, Juha, Avdicova, Maria, Azevedo, Ana, Azimi-Nezhad, Mohsen, Azizi, Fereidoun, Azmin, Mehrdad, Babu, Bontha V, Jorgensen, Maja Baeksgaard, Baharudin, Azli, Bahijri, Suhad, Baker, Jennifer L, Balakrishna, Nagalla, Bamoshmoosh, Mohamed, Banach, Maciej, Bandosz, Piotr, Banegas, Jose R, Baran, Joanna, Barbagallo, Carlo M, Barcelo, Alberto, Barkat, Amina, Barros, Aluisio JD, Barros, Mauro Virgilio Gomes, Basit, Abdul, Bastos, Joao Luiz D, Bata, Iqbal, Batieha, Anwar M, Batista, Rosangela L, Battakova, Zhamilya, Batyrbek, Assembekov, Baur, Louise A, Beaglehole, Robert, Bel-Serrat, Silvia, Belavendra, Antonisamy, Ben Romdhane, Habiba, Benedics, Judith, Benet, Mikhail, Berkinbayev, Salim, Bernabe-Ortiz, Antonio, Bernotiene, Gailute, Bettiol, Heloisa, Bezerra, Jorge, Bhagyalaxmi, Aroor, Bharadwaj, Sumit, Bhargava, Santosh K, Bi, Hongsheng, Bi, Yufang, Bia, Daniel, Lele, Elysee Claude Bika, Bikbov, Mukharram M, Bista, Bihungum, Bjelica, Dusko J, Bjerregaard, Peter, Bjertness, Espen, Bjertness, Marius B, Bjorkelund, Cecilia, Bloch, Katia V, Blokstra, Anneke, Bo, Simona, Bobak, Martin, Boddy, Lynne M, Boehm, Bernhard O, Boeing, Heiner, Boggia, Jose G, Bogova, Elena, Boissonnet, Carlos P, Bojesen, Stig E, Bonaccio, Marialaura, Bongard, Vanina, Bonilla-Vargas, Alice, Bopp, Matthias, Borghs, Herman, Bovet, Pascal, Braeckevelt, Lien, Braeckman, Lutgart, Bragt, Marjolijn CE, Brajkovich, Imperia, Branca, Francesco, Breckenkamp, Juergen, Breda, Joao, Brenner, Hermann, Brewster, Lizzy M, Brian, Garry R, Brinduse, Lacramioara, Brophy, Sinead, Bruno, Graziella, Bueno-de-Mesquita, H Bas, Bugge, Anna, Buoncristiano, Marta, Burazeri, Genc, Burns, Con, de Leon, Antonio Cabrera, Cacciottolo, Joseph, Cai, Hui, Cama, Tilema, Cameron, Christine, Camolas, Jose, Can, Gunay, Candido, Ana Paula C, Canete, Felicia, Capanzana, Mario V, Capkova, Nadezda, Capuano, Eduardo, Capuano, Vincenzo, Cardol, Marloes, Cardoso, Viviane C, Carlsson, Axel C, Carmuega, Esteban, Carvalho, Joana, Casajus, Jose A, Casanueva, Felipe F, Celikcan, Ertugrul, Censi, Laura, Cervantes-Loaiza, Marvin, Cesar, Juraci A, Chamukuttan, Snehalatha, Chan, Angelique W, Chan, Queenie, Chaturvedi, Himanshu K, Chaturvedi, Nish, Rahim, Norsyamlina Che Abdul, Chen, Chien-Jen, Chen, Fangfang, Chen, Huashuai, Chen, Shuohua, Chen, Zhengming, Cheng, Ching-Yu, Cheraghian, Bahman, Chetrit, Angela, Chikova-Iscener, Ekaterina, Chiolero, Arnaud, Chiou, Shu-Ti, Chirlaque, Maria-Dolores, Cho, Belong, Christensen, Kaare, Christofaro, Diego G, Chudek, Jerzy, Cifkova, Renata, Cilia, Michelle, Cinteza, Eliza, Claessens, Frank, Clarke, Janine, Clays, Els, Cohen, Emmanuel, Concin, Hans, Confortin, Susana C, Cooper, Cyrus, Coppinger, Tara C, Corpeleijn, Eva, Costanzo, Simona, Cottel, Dominique, Cowell, Chris, Craig, Cora L, Crampin, Amelia C, Crujeiras, Ana B, Csilla, Semanova, Cucu, Alexandra M, Cui, Liufu, Cureau, Felipe V, D'Arrigo, Graziella, d'Orsi, Eleonora, Dacica, Liliana, Saavedra, Maria Angeles Dal Re, Dallongeville, Jean, Damasceno, Albertino, Damsgaard, Camilla T, Dankner, Rachel, Dantoft, Thomas M, Dasgupta, Parasmani, Dastgiri, Saeed, Dauchet, Luc, Davletov, Kairat, De Backer, Guy, De Bacquer, Dirk, de Gaetano, Giovanni, De Henauw, Stefaan, de Oliveira, Paula Duarte, De Ridder, David, De Ridder, Karin, de Rooij, Susanne R, De Smedt, Delphine, Deepa, Mohan, Deev, Alexander D, DeGennaro, Vincent, Dehghan, Abbas, Delisle, Helene, Delpeuch, Francis, Demarest, Stefaan, Dennison, Elaine, Deren, Katarzyna, Deschamps, Valerie, Dhana, Klodian, Dhimal, Meghnath, Di Castelnuovo, Augusto F, Dias-da-Costa, Juvenal Soares, Diaz-Sanchez, Maria Elena, Diaz, Alejandro, Dika, Zivka, Djalalinia, Shirin, Djordjic, Visnja, Do, Ha TP, Dobson, Annette J, Donati, Maria Benedetta, Donfrancesco, Chiara, Donoso, Silvana P, Doring, Angela, Dorobantu, Maria, Dorosty, Ahmad Reza, Doua, Kouamelan, Drygas, Wojciech, Duan, Jia Li, Duante, Charmaine A, Duboz, Priscilla, Duda, Rosemary B, Duleva, Vesselka, Dulskiene, Virginija, Dumith, Samuel C, Dushpanova, Anar, Dzerve, Vilnis, Dziankowska-Zaborszczyk, Elzbieta, Eddie, Ricky, Eftekhar, Ebrahim, Egbagbe, Eruke E, Eggertsen, Robert, Eghtesad, Sareh, Eiben, Gabriele, Ekelund, Ulf, El-Khateeb, Mohammad, El Ati, Jalila, Eldemire-Shearer, Denise, Eliasen, Marie, Elliott, Paul, Engle-Stone, Reina, Enguerran, Macia, Erasmus, Rajiv T, Erbel, Raimund, Erem, Cihangir, Eriksen, Louise, Eriksson, Johan G, Escobedo-de la Pena, Jorge, Eslami, Saeid, Esmaeili, Ali, Evans, Alun, Faeh, David, Fakhretdinova, Albina A, Fall, Caroline H, Faramarzi, Elnaz, Farjam, Mojtaba, Sant'Angelo, Victoria Farrugia, Farzadfar, Farshad, Fattahi, Mohammad Reza, Fawwad, Asher, Felix-Redondo, Francisco J, Ferguson, Trevor S, Fernandes, Romulo A, Fernandez-Berges, Daniel, Ferrante, Daniel, Ferrao, Thomas, Ferrari, Marika, Ferrario, Marco M, Ferreccio, Catterina, Ferrer, Eldridge, Ferrieres, Jean, Figueiro, Thamara Hubler, Fijalkowska, Anna, Fink, Gunther, Fischer, Krista, Foger, Bernhard, Foo, Leng Huat, Forsner, Maria, Fouad, Heba M, Francis, Damian K, Franco, Maria do Carmo, Franco, Oscar H, Frikke-Schmidt, Ruth, Frontera, Guillermo, Fuchs, Flavio D, Fuchs, Sandra C, Fujiati, Isti I, Fujita, Yuki, Fumihiko, Matsuda, Furusawa, Takuro, Gaciong, Zbigniew, Gafencu, Mihai, Galbarczyk, Andrzej, Galenkamp, Henrike, Galeone, Daniela, Galfo, Myriam, Galvano, Fabio, Gao, Jingli, Garcia-de-la-Hera, Manoli, Garcia-Solano, Marta, Gareta, Dickman, Garnett, Sarah P, Gaspoz, Jean-Michel, Gasull, Magda, Gaya, Adroaldo Cesar Araujo, Gaya, Anelise Reis, Gazzinelli, Andrea, Gehring, Ulrike, Geiger, Harald, Geleijnse, Johanna M, Ghanbari, Ali, Ghasemi, Erfan, Gheorghe-Fronea, Oana-Florentina, Giampaoli, Simona, Gianfagna, Francesco, Gill, Tiffany K, Giovannelli, Jonathan, Gironella, Glen, Giwercman, Aleksander, Gkiouras, Konstantinos, Godos, Justyna, Gogen, Sibel, Goldsmith, Rebecca A, Goltzman, David, Gomez, Santiago F, Gomula, Aleksandra, da Silva, Bruna Goncalves Cordeiro, Goncalves, Helen, Gonzalez-Chica, David A, Gonzalez-Gross, Marcela, Gonzalez-Leon, Margot, Gonzalez-Rivas, Juan P, Gonzalez-Villalpando, Clicerio, Gonzalez-Villalpando, Maria-Elena, Gonzalez, Angel R, Gottrand, Frederic, Graca, Antonio Pedro, Graff-Iversen, Sidsel, Grafnetter, Dusan, Grajda, Aneta, Grammatikopoulou, Maria G, Gregor, Ronald D, Grodzicki, Tomasz, Groholt, Else Karin, Grontved, Anders, Grosso, Giuseppe, Gruden, Gabriella, Gu, Dongfeng, Gualdi-Russo, Emanuela, Guallar-Castillon, Pilar, Gualtieri, Andrea, Gudmundsson, Elias F, Gudnason, Vilmundur, Guerrero, Ramiro, Guessous, Idris, Guimaraes, Andre L, Gulliford, Martin C, Gunnlaugsdottir, Johanna, Gunter, Marc J, Guo, Xiu-Hua, Guo, Yin, Gupta, Prakash C, Gupta, Rajeev, Gureje, Oye, Gurzkowska, Beata, Gutierrez-Gonzalez, Enrique, Gutierrez, Laura, Gutzwiller, Felix, Ha, Seongjun, Hadaegh, Farzad, Hadjigeorgiou, Charalambos A, Haghshenas, Rosa, Hakimi, Hamid, Halkjaer, Jytte, Hambleton, Ian R, Hamzeh, Behrooz, Hange, Dominique, Hanif, Abu AM, Hantunen, Sari, Kumar, Rachakulla Hari, Hashemi-Shahri, Seyed Mohammad, Hassapidou, Maria, Hata, Jun, Haugsgjerd, Teresa, Hayes, Alison J, He, Jiang, He, Yuan, He, Yuna, Heidinger-Felso, Regina, Heinen, Mirjam, Hejgaard, Tatjana, Hendriks, Marleen Elisabeth, Henrique, Rafael dos Santos, Henriques, Ana, Cadena, Leticia Hernandez, Herrala, Sauli, Herrera, Victor M, Herter-Aeberli, Isabelle, Heshmat, Ramin, Hill, Allan G, Ho, Sai Yin, Ho, Suzanne C, Hobbs, Michael, Hofman, Albert, Bergh, Ingunn Holden, Holdsworth, Michelle, Homayounfar, Reza, Homs, Clara, Hopman, Wilma M, Horimoto, Andrea RVR, Hormiga, Claudia M, Horta, Bernardo L, Houti, Leila, Howitt, Christina, Thein, Thein Htay, Htet, Aung Soe, Htike, Maung Maung Than, Hu, Yonghua, Huerta, Jose Maria, Huhtaniemi, Ilpo Tapani, Petrescu, Constanta Huidumac, Husseini, Abdullatif, Chinh, Nguyen Huu, Huybrechts, Inge, Hwalla, Nahla, Hyska, Jolanda, Iacoviello, Licia, Ibarluzea, Jesus M, Ibrahim, Mohsen M, Wong, Norazizah Ibrahim, Ikeda, Nayu, Ikram, M Arfan, Iotova, Violeta, Irazola, Vilma E, Ishida, Takafumi, Islam, Muhammad, Islam, Sheikh Mohammed Shariful, Iwasaki, Masanori, Jackson, Rod T, Jacobs, Jeremy M, Jaddou, Hashem Y, Jafar, Tazeen, James, Kenneth, Jamil, Kazi M, Jamrozik, Konrad, Janszky, Imre, Janus, Edward, Jarani, Juel, Jarvelin, Marjo-Riitta, Jasienska, Grazyna, Jelakovic, Ana, Jelakovic, Bojan, Jennings, Garry, Jha, Anjani Kumar, Jiang, Chao Qiang, Jimenez, Ramon O, Jockel, Karl-Heinz, Joffres, Michel, Johansson, Mattias, Jokelainen, Jari J, Jonas, Jost B, Jorgensen, Torben, Joshi, Pradeep, Joukar, Farahnaz, Jovic, Dragana P, Jozwiak, Jacek J, Juolevi, Anne, Jurak, Gregor, Simina, Iulia Jurca, Juresa, Vesna, Kaaks, Rudolf, Kaducu, Felix O, Kafatos, Anthony, Kajantie, Eero O, Kalmatayeva, Zhanna, Kalter-Leibovici, Ofra, Kameli, Yves, Kanala, Kodanda R, Kannan, Srinivasan, Kapantais, Efthymios, Karki, Khem B, Katibeh, Marzieh, Katz, Joanne, Katzmarzyk, Peter T, Kauhanen, Jussi, Kaur, Prabhdeep, Kavousi, Maryam, Kazakbaeva, Gyulli M, Keil, Ulrich, Boker, Lital Keinan, Keinanen-Kiukaanniemi, Sirkka, Kelishadi, Roya, Kelleher, Cecily, Kemper, Han CG, Keramati, Maryam, Kerimkulova, Alina, Kersting, Mathilde, Key, Timothy, Khader, Yousef Saleh, Khalili, Davood, Khaw, Kay-Tee, Kheiri, Bahareh, Kheradmand, Motahareh, Khosravi, Alireza, Khouw, Ilse MSL, Kiechl-Kohlendorfer, Ursula, Kiechl, Stefan, Killewo, Japhet, Kim, Dong Wook, Kim, Hyeon Chang, Kim, Jeongseon, Kindblom, Jenny M, Klakk, Heidi, Klimek, Magdalena, Klimont, Jeannette, Klumbiene, Jurate, Knoflach, Michael, Koirala, Bhawesh, Kolle, Elin, Kolsteren, Patrick, Konig, Jurgen, Korpelainen, Raija, Korrovits, Paul, Korzycka, Magdalena, Kos, Jelena, Koskinen, Seppo, Kouda, Katsuyasu, Kovacs, Viktoria A, Kowlessur, Sudhir, Koziel, Slawomir, Kratzer, Wolfgang, Kriemler, Susi, Kristensen, Peter Lund, Krokstad, Steiner, Kromhout, Daan, Krtalic, Branimir, Kruger, Herculina S, Kubinova, Ruzena, Kuciene, Renata, Kujala, Urho M, Kujundzic, Enisa, Kulaga, Zbigniew, Kumar, R Krishna, Kunesova, Marie, Kurjata, Pawel, Kusuma, Yadlapalli S, Kuulasmaa, Kari, Kyobutungi, Catherine, Quang, Ngoc La, Laamiri, Fatima Zahra, Laatikainen, Tiina, Lachat, Carl, Laid, Youcef, Lam, Tai Hing, Lambrinou, Christina-Paulina, Landais, Edwige, Lanska, Vera, 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Ferrario MM, Ferreccio C, Ferrer E, Ferrieres J, Figueiró TH, Fijalkowska A, Fink G, Fischer K, Föger B, Foo LH, Forsner M, Fouad HM, Francis DK, Franco MDC, Franco OH, Frikke-Schmidt R, Frontera G, Fuchs FD, Fuchs SC, Fujiati II, Fujita Y, Fumihiko M, Furusawa T, Gaciong Z, Gafencu M, Galbarczyk A, Galenkamp H, Galeone D, Galfo M, Galvano F, Gao J, Garcia-de-la-Hera M, García-Solano M, Gareta D, Garnett SP, Gaspoz J-M, Gasull M, Gaya ACA, Gaya AR, Gazzinelli A, Gehring U, Geiger H, Geleijnse JM, Ghanbari A, Ghasemi E, Gheorghe-Fronea O-F, Giampaoli S, Gianfagna F, Gill TK, Giovannelli J, Gironella G, Giwercman A, Gkiouras K, Godos J, Gogen S, Goldsmith RA, Goltzman D, Gómez SF, Gomula A, Goncalves Cordeiro da Silva B, Gonçalves H, Gonzalez-Chica DA, Gonzalez-Gross M, González-Leon M, González-Rivas JP, González-Villalpando C, González-Villalpando M-E, Gonzalez AR, Gottrand F, Graça AP, Graff-Iversen S, Grafnetter D, Grajda A, Grammatikopoulou MG, Gregor RD, Grodzicki T, Grøholt EK, 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Nordestgaard B.G., Noto D., Nowak-Szczepanska N., Nsour M.A., Nuhoglu I., Nurk E., O'Neill T.W., O'Reilly D., Obreja G., Ochimana C., Ochoa-Aviles A.M., Oda E., Oh K., Ohara K., Ohlsson C., Ohtsuka R., Olafsson O., Olinto M.T.A., Oliveira I.O., Omar M.A., Onat A., Ong S.K., Ono L.M., Ordunez P., Ornelas R., Ortiz A.P., Ortiz P.J., Osler M., Osmond C., Ostojic S.M., Ostovar A., Otero J.A., Overvad K., Owusu-Dabo E., Paccaud F.M., Padez C., Pagkalos I., Pahomova E., Paiva K.M.D., Pajak A., Palli D., Palloni A., Palmieri L., Pan W.-H., Panda-Jonas S., Pandey A., Panza F., Papandreou D., Park S.-W., Park S., Parnell W.R., Parsaeian M., Pascanu I.M., Pasquet P., Patel N.D., Pednekar M.S., Peer N., Peixoto S.V., Peltonen M., Pereira A.C., Peres M.A., Perez-Farinos N., Perez C.M., Peterkova V., Peters A., Petersmann A., Petkeviciene J., Petrauskiene A., Pettenuzzo E., Peykari N., Pham S.T., Pichardo R.N., Pierannunzio D., Pigeot I., Pikhart H., Pilav A., Pilotto L., Pistelli F., Pitakaka F., 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Male, body-mass index, ADULTHOOD, Adolescents, pituuskasvu, Pediatrics, Body Mass Index, 0302 clinical medicine, Child Development, nuoret, Public health surveillance, Medicine, Health Status Indicators, 10. No inequality, Child, 11 Medical and Health Sciences, Body mass index, ComputingMilieux_MISCELLANEOUS, education.field_of_study, VDP::Medisinske Fag: 700::Helsefag: 800::Samfunnsmedisin, sosialmedisin: 801, General Medicine, Body mass indexes, kansainvälinen vertailu, 3. Good health, Geography, Health, 030220 oncology & carcinogenesis, Child, Preschool, Medical and Health sciences, purl.org/becyt/ford/3 [https], medicine.medical_specialty, School-aged adolescents, Socio-culturale, lapset (ikäryhmät), Nursing, territories, ravinto, purl.org/becyt/ford/3.3 [https], 03 medical and health sciences, School Children, SDG 3 - Good Health and Well-being, SYSTEMATIC ANALYSIS, Humans, school-aged children and adolescents, Montenegro, education, Science & Technology, Omvårdnad, Health sciences, Medical and Health sciences, Ciências médicas e da saúde, Bayes Theorem, Anthropometry, Adolescent Development, medicine.disease, TRENDS, Height and Body-mass Index, Faculdade de Ciências Sociais, UNDERNUTRITION, Height index trajectories, Height, body mass index, children , epidemiology, risk factors, growth, Stature, Demography, Settore MED/09 - Medicina Interna, Internationality, [SDV]Life Sciences [q-bio], 030204 cardiovascular system & hematology, Body-mass index trajectories, Epidemiology, Medicine and Health Sciences, risk factors, countries, EPIDEMIOLOGY, height, children, adolescents, BMI, 030212 general & internal medicine, painoindeksi, Child development, 2. Zero hunger, Medicine(all), School age child, obestity children cardiovascular, Population Health, 1. No poverty, Pediatrik, Public Health, Global Health, Social Medicine and Epidemiology, 3142 Public health care science, environmental and occupational health, Pooled analysis, NUTRITION, Female, medicine.symptom, pooled analysis, Life Sciences & Biomedicine, terveys, height, BMI, nutrition, health, children, adolescents, Adolescent, growth, Population, body-mass, Population based, Body-mass index, Young Adult, Medicine, General & Internal, Meta-Analysis as Topic, General & Internal Medicine, parasitic diseases, Weight gain, School-aged childrens, Age trajectories, business.industry, Height, Weight, Body Height, Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi, Malnutrition, ONSET, Ciências da Saúde, Ciências médicas e da saúde, School-aged children, VDP::Medical disciplines: 700::Health sciences: 800::Community medicine, Social medicine: 801, business, terveysriskit, Estilos de Vida e Impacto na Saúde
Abstract

BACKGROUND: Comparable global data on health and nutrition of school-aged children and adolescents are scarce. We aimed to estimate age trajectories and time trends in mean height and mean body-mass index (BMI), which measures weight gain beyond what is expected from height gain, for school-aged children and adolescents., METHODS: For this pooled analysis, we used a database of cardiometabolic risk factors collated by the Non-Communicable Disease Risk Factor Collaboration. We applied a Bayesian hierarchical model to estimate trends from 1985 to 2019 in mean height and mean BMI in 1-year age groups for ages 5–19 years. The model allowed for non-linear changes over time in mean height and mean BMI and for non-linear changes with age of children and adolescents, including periods of rapid growth during adolescence., FINDINGS: We pooled data from 2181 population-based studies, with measurements of height and weight in 65 million participants in 200 countries and territories. In 2019, we estimated a difference of 20 cm or higher in mean height of 19-year-old adolescents between countries with the tallest populations (the Netherlands, Montenegro, Estonia, and Bosnia and Herzegovina for boys; and the Netherlands, Montenegro, Denmark, and Iceland for girls) and those with the shortest populations (Timor-Leste, Laos, Solomon Islands, and Papua New Guinea for boys; and Guatemala, Bangladesh, Nepal, and Timor-Leste for girls). In the same year, the difference between the highest mean BMI (in Pacific island countries, Kuwait, Bahrain, The Bahamas, Chile, the USA, and New Zealand for both boys and girls and in South Africa for girls) and lowest mean BMI (in India, Bangladesh, Timor-Leste, Ethiopia, and Chad for boys and girls; and in Japan and Romania for girls) was approximately 9–10 kg/m2. In some countries, children aged 5 years started with healthier height or BMI than the global median and, in some cases, as healthy as the best performing countries, but they became progressively less healthy compared with their comparators as they grew older by not growing as tall (eg, boys in Austria and Barbados, and girls in Belgium and Puerto Rico) or gaining too much weight for their height (eg, girls and boys in Kuwait, Bahrain, Fiji, Jamaica, and Mexico; and girls in South Africa and New Zealand). In other countries, growing children overtook the height of their comparators (eg, Latvia, Czech Republic, Morocco, and Iran) or curbed their weight gain (eg, Italy, France, and Croatia) in late childhood and adolescence. When changes in both height and BMI were considered, girls in South Korea, Vietnam, Saudi Arabia, Turkey, and some central Asian countries (eg, Armenia and Azerbaijan), and boys in central and western Europe (eg, Portugal, Denmark, Poland, and Montenegro) had the healthiest changes in anthropometric status over the past 3·5 decades because, compared with children and adolescents in other countries, they had a much larger gain in height than they did in BMI. The unhealthiest changes—gaining too little height, too much weight for their height compared with children in other countries, or both—occurred in many countries in sub-Saharan Africa, New Zealand, and the USA for boys and girls; in Malaysia and some Pacific island nations for boys; and in Mexico for girls., INTERPRETATION: The height and BMI trajectories over age and time of school-aged children and adolescents are highly variable across countries, which indicates heterogeneous nutritional quality and lifelong health advantages and risks., Wellcome Trust, AstraZeneca Young Health Programme, EU., peer-reviewed

Published
2020
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12. A discrete long-term location-price problem under the assumption of discriminatory pricing: Formulations and parametric analysis

Author

Fernandez, Pascual, Pelegrin, Blas, Perez, MariA Dolores GarciA, and Peeters, Peter H.

Subjects
Business, Business, general, Business, international
Abstract

To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.ejor.2005.03.075 Byline: Pascual Fernandez (a), Blas Pelegrin (a), Maria Dolores Garcia Perez (b), Peter H. Peeters (c) Keywords: Discrete location; Competition; Discriminatory pricing Abstract: We consider a competitive location problem in which a new firm has to make decisions on the locations of several new facilities as well as on its price setting in order to maximise profit. Under the assumption of discriminatory prices, competing firms set a specific price for each market area. The customers buy one unit of a single homogeneous price-inelastic product from the facility that offers the lowest price in the area the consumers belong to. Three customer choice rules are considered in order to break ties in the offered prices. We prove that, considering long-term competition on price, this problem can be reduced to a problem with decisions on location only. For each one of the choice rules the location problem is formulated as an integer programming model and a parametric analysis of these models is given. To conclude, an application with real data is presented. Author Affiliation: (a) Universidad de Murcia, Campus del Espinardo, 30100 Espinardo, Murcia, Spain (b) Universidad Catolica San Antonio, Av. de los Jeronimos, 30107 Guadalupe, Murcia, Spain (c) Vrije Universiteit Brussel, Pleinlaan, 2, B-1050 Brussels, Belgium Article History: Received 15 December 2003; Accepted 15 March 2005

Published
2007

13. Fairs and markets in Galicia in the late eighteenth century

Author

del Mar Lopez Perez, Maria

Subjects
Markets (Economics) -- Research -- Economic aspects -- 18th century AD, Trade shows -- Economic aspects -- Research -- 18th century AD, Industrial productivity -- Research -- Economic aspects -- 18th century AD, Business, Economics, Business, international, Productivity, Trade show, Economic aspects, Research
Abstract

Abstract This paper analyses the progressive unification of the domestic market during the eighteenth century by three means. First, the intensification of commercial trade, due to the increase of authorized [...]

Published
2007

14. Are Web self-assessment tools useful for training?

Author

Perez, Maria S., Herrero, Pilar, Sanchez, Francisco M., and Robles, Victor

Subjects
Universities and colleges -- Technology application, Universities and colleges -- Spain, Computerized testing -- Usage, Computerized testing -- Evaluation, Technology application, Business, Education, Electronics, Electronics and electrical industries
Abstract

This paper presents the negative experience carried out by using a Web self-assessment tool (WSAT) called AulaWeb, developed by the Universidad Politecnica de Madrid (UPM), Madrid, Spain, to train engineers. The main goal in using this tool was to motivate students to improve their learning and results in a computing subject. Over 800 students take this subject every year, and the failure rate is high. Nevertheless, the results achieved were the opposite of what was expected. This paper uncovers the mistakes made and provides important tips for teachers facing a similar problem with a subject or for teachers who would like to use WSATs to improve students' learning. This advice is based on the analysis and comparison of the results achieved over five consecutive academic years, in two of which AulaWeb was used. Index Terms--Education, evaluation, Internet, self-learning, Web self-assessment tools (WSATs).

Published
2005

15. Multimode cavity efficiency optimization by optimum load location--experimental approach

Author

Requena-Perez, Maria E., Pedreno-Molina, Juan L., Monzo-Cabrera, Juan, and Diaz-Morcillo, Alejandro

Subjects
Microwave devices -- Research, Business, Computers, Electronics, Electronics and electrical industries
Abstract

In this paper, a novel load-matching procedure for microwave-heating applicators is presented and tested. In order to accomplish the optimization procedure, an optimization method based on the use of the Lebenverg-Marquardt technique has been specifically developed and tested on two different microwave ovens. The proposed procedure allows an efficient optimization of three-dimensional microwave applicators by means of the dielectric sample relocation as a function of its complex permittivity, size, and operating frequency. Experimental measurements of the reflection coefficient are presented and analyzed over several samples and multimode cavities. Results indicate that high power efficiencies can be obtained provided that operating frequency is not just below TM-mode cutoff frequencies for the transverse dimensions of the oven. Index Terms--Electromagnetic heating, load matching, multimode applicator, power efficiency.

Published
2005

17. An emergent, high-fatality lung disease in systemic juvenile arthritis

Author

Saper, Vivian, Chen, Guangbo, Deutsch, Gail, Guillerman, R. Paul, Birgmeier, Johannes, Jagadeesh, Karthik, Canna, Scott, Schulert, Grant, Deterding, Robin, Xu, Jianpeng, Leung, Ann, Qin, Xuan, Bouzoubaa, Layla, Abulaban, Khalid, Baszis, Kevin, Behrens, Edward, Birmingham, James, Casey, Alicia, Cidon, Michal, Cron, Randy, De, Aliva, De Benedetti, Fabrizio, Ferguson, Ian, Fishman, Martha, Goodman, Steven, Graham, Brent, Grom, Alexei, Haines, Kathleen, Hazen, Melissa, Henderson, Lauren, Ho, Assunta, Ibarra, Maria, Inman, CJ, Jerath, Rita, Khawaja, Khulood, Kingsbury, Daniel, Klein-Gitelman, Marisa, Lai, Khan, Lapidus, Sivia, Lin, Clara, Lin, Jenny, Liptzin, Deborah, Milojevic, Diana, Mombourquette, Joy, Onel, Karen, Ozen, Seza, Perez, Maria, Phillippi, Kathryn, Prahalad, Sampath, Radhakrishna, Suhas, Reinhardt, Adam, Riskalla, Mona, Rosenwasser, Natalie, Roth, Johannes, Schneider, Rayfel, Schonenberg-Meinema, Dieneke, Shenoi, Susan, Smith, Judith A, Sonmez, Hafize, Stoll, Matthew, Towe, Christopher, Vargas, Sara, Vehe, Richard, Young, Lisa R, Yang, Jacqueline, Desai, Tushar, Balise, Raymond, Lu, Ying, Tian, Lu, Bejerano, Gil, Davis, Mark M, Khatri, Purvesh, and Mellins, Elizabeth

Subjects
030203 arthritis & rheumatology, 0303 health sciences, medicine.medical_specialty, business.industry, Arthritis, Interleukin, Retrospective cohort study, medicine.disease, Gastroenterology, 3. Good health, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Tocilizumab, chemistry, Internal medicine, Macrophage activation syndrome, Concomitant, medicine, Trisomy, Pulmonary alveolar proteinosis, business, 030304 developmental biology
Abstract

ObjectiveTo investigate characteristics and risk factors of a novel parenchymal lung disease, increasingly detected in systemic juvenile idiopathic arthritis (sJIA).MethodsIn a multi-center retrospective study, 61 cases were investigated, using physician-reported clinical information and centralized analyses of radiologic, pathologic and genetic data.ResultsLung disease (LD) was associated with distinctive features, including acute erythematous clubbing and a high frequency of anaphylactic reactions to the IL-6 inhibitor, tocilizumab. Serum ferritin elevation and/or significant lymphopenia preceded LD detection. The most prevalent chest CT pattern was septal thickening, involving the periphery of multiple lobes +/- ground glass opacities. Predominant pathology (23/36) was pulmonary alveolar proteinosis and/or endogenous lipoid pneumonia (PAP/ELP), with atypical features, including regional involvement and concomitant vascular changes. Apparent severe delayed drug hypersensitivity occurred in some cases. 5-year survival was 42%. Whole-exome sequencing (20/61) did not identify a novel monogenic defect PAP-related or macrophage activation syndrome (MAS)-related mutations as likely primary cause. Trisomy 21 (T21) increased LD risk, as did young sJIA onset. Refractory sJIA was not required for LD development. Exposure to interleukin (IL)-1 and IL-6 inhibitors (46/61) was associated with multiple LD features. By several indicators, severity of sJIA was comparable in drug-exposed subjects and published sJIA cohorts. MAS at sJIA onset was increased in the drug-exposed, but it was not associated with LD features.ConclusionsA rare, life-threatening LD in sJIA is defined by a constellation of unusual clinical characteristics. The pathology, a PAP/ELP variant, suggests macrophage dysfunction. Inhibitor exposure may promote LD, independent of sJIA severity, in a small subset of treated patients. Treatment/prevention strategies are needed.

Published
2019
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19. Organizational learning and market orientation: interface and effects on performance

Author

Santos-Vijande, MariA Leticia, Sanzo-Perez, MariA Jose, Alvarez-Gonzalez, Luis I., and Vazquez-Casielles, Rodolfo

Subjects
Advertising, marketing and public relations, Business, Business, international
Abstract

To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.indmarman.2004.08.004 Byline: Maria Leticia Santos-Vijande, Maria Jose Sanzo-Perez, Luis I. Alvarez-Gonzalez, Rodolfo Vazquez-Casielles Keywords: Organizational learning; Learning orientation; Market orientation; Business performance; Relationship marketing Abstract: This paper discusses the relationship between market orientation and organizational learning and, in particular, the former's contribution to the generation of double-loop learning. Although prior contributions on this topic have been controversial, the authors, departing from the principles of RBV, consider market orientation a resource capable of generating higher order organizational learning and, in this way, capable of additionally reinforcing firms' sustainable competitive advantage. The empirical study provides evidence on the existing relationship between a firm's learning and market orientation degree and the organization's economic and non-economic results. Findings indicate that learning orientation stimulates the market-oriented behavior and that it also positively affects the establishment of long-term relationships with strategic clients. Contrary to prior research a significant and positive effect on business performance is only contrasted in the case of market orientation. Author Affiliation: Department of Business Administration, Business School, University of Oviedo, Avda. del Cristo, s/n, 33071, Oviedo, Asturias, Spain Article History: Received 25 June 2003; Revised 1 April 2004; Accepted 26 August 2004

Published
2005

20. Effectiveness of 23-valent pneumococcal polysaccharide vaccination in preventing community-acquired pneumonia hospitalization and severe outcomes in the elderly in Spain

Author

Dominguez, Angela, Soldevila, Nuria, Toledo, Diana, Torner, Nuria, Force, Luis, Jose Perez, Maria, Martin, Vicente, Rodriguez-Rojas, Lourdes, Astray, Jenaro, Egurrola, Mikel, Sanz, Francisco, Castilla, Jesus, Working Grp Project PI12 02079, [Dominguez, Angela] Univ Barcelona, Dept Salut Publ, Barcelona, Spain, [Soldevila, Nuria] Univ Barcelona, Dept Salut Publ, Barcelona, Spain, [Toledo, Diana] Univ Barcelona, Dept Salut Publ, Barcelona, Spain, [Torner, Nuria] Univ Barcelona, Dept Salut Publ, Barcelona, Spain, [Dominguez, Angela] CIBER Epidemiol & Salud Publ CIBERESP, Madrid, Spain, [Soldevila, Nuria] CIBER Epidemiol & Salud Publ CIBERESP, Madrid, Spain, [Toledo, Diana] CIBER Epidemiol & Salud Publ CIBERESP, Madrid, Spain, [Torner, Nuria] CIBER Epidemiol & Salud Publ CIBERESP, Madrid, Spain, [Castilla, Jesus] CIBER Epidemiol & Salud Publ CIBERESP, Madrid, Spain, [Torner, Nuria] Agencia Salut Publ Catalunya, Barcelona, Spain, [Force, Luis] Hosp Mataro, Mataro, Spain, [Jose Perez, Maria] Hosp Univ Virgen de Valme, Seville, Spain, [Martin, Vicente] Univ Leon, Leon, Spain, [Rodriguez-Rojas, Lourdes] Hosp Ramon & Cajal, Madrid, Spain, [Astray, Jenaro] Consejeria Sanidad, Madrid, Spain, [Egurrola, Mikel] Hosp Galdakao, Usansolo, Spain, [Sanz, Francisco] Univ Valencia, Consorci Hosp Gen, Valencia, Spain, [Castilla, Jesus] IdiSNA, Inst Salud Publ Navarra, Pamplona, Spain, National Plan of I+D+I, ISCIII-Subdreccion General de Evaluacion y Fomento de la Investigacion, Catalan Agency for the Management of Grants for University Research (AGAUR), Universitat de Barcelona, Instituto de Salud Carlos III, European Commission, and Generalitat de Catalunya

Subjects
Male, Pulmonology, Glycobiology, lcsh:Medicine, Pneumònia, Logistic regression, Vacunes, Biochemistry, Persones grans, law.invention, Pneumococcal Vaccines, 0302 clinical medicine, Elderly, Community-acquired pneumonia, law, Medicine and Health Sciences, Public and Occupational Health, Disease, 030212 general & internal medicine, Advisory-committee, lcsh:Science, General-population, Geriatrics, Aged, 80 and over, Vaccines, Multidisciplinary, Vaccination, Intensive care unit, Vaccination and Immunization, Hospitals, Community-Acquired Infections, Hospitalization, Intensive Care Units, Infectious Diseases, Impact, Pneumococcal pneumonia, Female, Research Article, medicine.medical_specialty, Infectious Disease Control, Immunology, 03 medical and health sciences, Conjugate vaccine, Polysaccharides, Internal medicine, medicine, Humans, Adults, Intensive care medicine, Aged, business.industry, lcsh:R, People, Biology and Life Sciences, Aged greater-than-or-equal-to-65 years, Pneumonia, Pneumonia, Pneumococcal, medicine.disease, Influenza, Health Care, Older, 030228 respiratory system, Age Groups, Health Care Facilities, Spain, Case-Control Studies, People and Places, Etiology, Population Groupings, lcsh:Q, Preventive Medicine, Older people, business, Polisacàrids
Abstract

Pneumococcal pneumonia is a serious cause of morbidity and mortality in the elderly, but investigation of the etiological agent of community-acquired pneumonia (CAP) is not possible in most hospitalized patients. The aim of this study was to estimate the effect of pneumococcal polysaccharide vaccination (PPSV23) in preventing CAP hospitalization and reducing the risk of intensive care unit admission (ICU) and fatal outcomes in hospitalized people aged ≥65 years. We made a multicenter case-control study in 20 Spanish hospitals during 2013–2014 and 2014–2015. We selected patients aged ≥65 years hospitalized with a diagnosis of pneumonia and controls matched by sex, age and date of hospitalization. Multivariate analysis was performed using conditional logistic regression to estimate vaccine effectiveness and unconditional logistic regression to evaluate the reduction in the risk of severe and fatal outcomes. 1895 cases and 1895 controls were included; 13.7% of cases and 14.4% of controls had received PPSV23 in the last five years. The effectiveness of PPSV23 in preventing CAP hospitalization was 15.2% (95% CI -3.1–30.3). The benefit of PPSV23 in avoiding ICU admission or death was 28.1% (95% CI -14.3–56.9) in all patients, 30.9% (95% CI -32.2–67.4) in immunocompetent patients and 26.9% (95% CI -38.6–64.8) in immunocompromised patients. In conclusion, PPSV23 showed a modest trend to avoidance of hospitalizations due to CAP and to the prevention of death or ICU admission in elderly patients hospitalized with a diagnosis of CAP., This study was funded by the National Plan of I+D+I 2008-2011 and ISCIII-Subdirección General de Evaluación y Fomento de la Investigación (Project PI12/02079) and cofounded by FEDER and the Catalan Agency for the Management of Grants for University Research (AGAUR Grant number 2014/ SGR 1403).

Published
2017
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21. Adrenal insufficiency due to X-linked adrenoleukodystrophy diagnosed in late adulthood

Author

Gogorza Perez Maria Soledad, Portilla Ana Jimenez, Soler Guillermo Serra, Marcet Mercedes Codina, Macazaga Vicente Pereg, Fernández Honorato García, Jiménez Iñaki Argüelles, Marzena Wos, Povedano Santiago Tofé, and Ribas Elena Mena

Subjects
medicine.medical_specialty, Endocrinology, business.industry, Internal medicine, X-linked adrenoleukodystrophy, Adrenal insufficiency, Medicine, business, medicine.disease
Published
2016
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22. Trends in adult body-mass index in 200 countries from 1975 to 2014: a pooled analysis of 1698 population-based measurement studies with 19.2 million participants

Author

Cesare, Mariachiara Di, Bentham, James, Stevens, Gretchen A., Zhou, Bin, Danaei, Goodarz, Lu, Yuan, Bixby, Honor, Cowan, Melanie J., Riley, Leanne M., Hajifathalian, Kaveh, Fortunato, Lea, Taddei, C., Bennett, James E., Ikeda, Nayu, Khang, Young-Ho, Kyobutungi, Catherine, Laxmaiah, Avula, Li, Yanping, Lin, Hsien-Ho, Miranda, J. Jaime, Mostafa, Aya, Turley, Maria L., Paciorek, Christopher J., Gunter, Marc, Ezzati, Majid, Abdeen, Ziad A., Hamid, Zargar Abdul, Abu-Rmeileh, Niveen M., Acosta-Cazares, Benjamin, Adams, Robert, Aekplakorn, Wichai, Aguilar-Salinas, Carlos A., Agyemang, Charles, Ahrens, Wolfgang, Ali, Farhan, Alkerwi, Ala'a, Alvarez-Pedrerol, Mar, Aly, Eman, Amouyel, Philippe, Amuzu, Antoinette, Andersen, Lars Bo, Anderssen, Sigmund A., Andrade, Dolores S., Anjana, Ranjit Mohan, Aounallah-Skhiri, Hajer, Ariansen, Inger, Aris, Tahir, Arlappa, Nimmathota, Arveiler, Dominique, Assah, Felix K., Avdicova, Maria, Azizi, Fereidoun, Babu, Bontha V., Balakrishna, Nagalla, Bandosz, Piotr, Banegas, Jose R., Barbagallo, Carlo M., Barcelo, Alberto, Barkat, Amina, Barros, Mauro V., Bata, Iqbal, Batieha, Anwar M., Batista, Rosangela L., Baur, Louise A., Beaglehole, Robert, Romdhane, H. B., Benet, Mikhail, Bernabe-Ortiz, Antonio, Bernotine, Gailute, Bettiol, Heloisa, Bhagyalaxmi, Aroor, Bharadwaj, Sumit, Bhargava, Santosh K., Bhatti, Zaid, Bhutta, Zulfiqar A., Bi, HongSheng, Bi, Yufang, Bjerregaard, Peter, Bjertness, Espen, Bjertness, Marius B., Bjorkelund, Cecilia, Blake, Margaret, Blokstra, Anneke, Bo, Simona, Bobak, Martin, Boddy, Lynne M., Boehm, Bernhard O., Boeing, Heiner, Boissonnet, Carlos P., Bongard, Vanina, Bovet, Pascal, Bradbury, Mark, Bragt, Marjolijn C. E., Brajkovich, Imperia, Branca, Francesco, Breckenkamp, Juergen, Brenner, Hermann, Brewster, Lizzy M., Brian, Garry R., Bruno, Graziella, Bueno-de-Mesquita, H. B., Bugge, Anna, Burns, C., Leon, Antonio Cabrera de, Cacciottolo, Joseph, Cama, Tilema, Cameron, Christine, Camolas, Jose, Can, Gunay, Candido, Ana Paula C., Capuano, Vincenzo, Cardoso, Viviane C., Carvalho, Maria J., Casanueva, Felipe F., Casas, Juan-Pablo, Caserta, Carmelo A., Castetbon, Katia, Chamukuttan, Snehalatha, Chan, Angelique W., Chan, Queenie, Chaturvedi, Himanshu K., Chaturvedi, Nishi, Chen, Chien-Jen, Chen, Fangfang, Chen, Shuohua, Chen, Y. Z., Cheng, Ching-Yu, Chetrit, Angela, Chiolero, Arnaud, Chiou, Shu-Ti, Chirita-Emandi, Adela, Cho, Yumi, Christensen, Kaare, Chudek, Jerzy, Cifkova, Renata, Claessens, Frank, Clays, Els, Concin, Hans, Cooper, Cyrus, Cooper, Rachel, Coppinger, Tara C., Costanzo, Simona, Cottel, Dominique, Cowell, Chris, Craig, Cora L., Crujeiras, Ana B., D'Arrigo, Graziella, d'Orsi, Eleonora, Dallongeville, Jean, Damasceno, Albertino, Damsgaard, Camilla T., Dankner, Rachel, Dauchet, Luc, Backer, Guy De, Bacquer, Dirk De, Gaetano, Giovanni de, Hanauw, Stefaan De, Smedt, Delphine De, Deepa, Mohan, Deev, Alexander D., Dehghan, Abbas, Delisle, Helene, Delpeuch, Francis, Dhana, Klodian, Castelnuovo, Augusto F. Di, Dias-da-Costa, Juvenal Soares, Diaz, Alejandro, Djalalinia, Shirin, Do, Ha T. P., Dobson, Annette J., Donfrancesco, Chiara, Döring, A., Doua, Kouamelan, Drygas, Wojciech, Egbagbe, Eruke E., Eggertsen, Robert, Ekelund, Ulf, Ati, Jalila El, Elliott, Paul, Engle-Stone, Reina, Erasmus, Rajiv T., Erem, Cihangir, Eriksen, Louise, Peña, J. E. De La, Evans, Alun, Faeh, David, Fall, Caroline H., Farzadfar, Farshad, Felix-Redondo, Francisco J., Ferguson, Trevor S., Fernandez-Berges, Daniel, Ferrante, Daniel, Ferrari, Marika, Ferreccio, Catterina, Ferrieres, Jean, Finn, Joseph D., Fischer, Krista, Flores, E. M., Foeger, Bernhard, Foo, Leng Huat, Forslund, Ann-Sofie, Fortmann, Stephen P., Fouad, Heba M., Francis, Damian K., Franco, M. Do Carmo, Franco, Oscar H., Frontera, Guillermo, Fuchs, Flavio D., Fuchs, Sandra C., Fujita, Yuki, Furusawa, Takuro, Gaciong, Zbigniew, Gafencu, Mihai, Gareta, Dickman, Garnett, Sarah P., Gaspoz, Jean-Michel, Gasull, Magda, Gates, Louise, Geleijnse, Johanna M., Ghasemian, Anoosheh, Giampaoli, Simona, Gianfagna, Francesco, Giovannelli, Jonathan, Giwercman, Aleksander, Goldsmith, Rebecca A., Gross, M. G., Rivas, J. P. G., Gorbea, M. B., Gottrand, Frederic, Graff-Iversen, Sidsel, Grafnetter, Dusan, Grajda, Aneta, Grammatikopoulou, Maria G., Gregor, Ronald D., Grodzicki, Tomasz, Grontved, Anders, Gruden, Grabriella, Grujic, Vera, Gu, Dongfeng, Guan, Ong Peng, Gudnason, Vilmundur, Guerrero, Ramiro, Guessous, Idris, Guimaraes, Andre L., Gulliford, Martin C., Gunnlaugsdottir, Johanna, Guo, Xiu H., Guo, Yin, Gupta, Prakash C., Gureje, Oye, Gurzkowska, Beata, Gutierrez, Laura, Gutzwiller, Felix, Halkjaer, Jytte, Hardy, Rebecca, Kumar, Rachakulla Hari, Hayes, Alison J., He, Jiang, Hendriks, Marleen Elisabeth, Cadena, L. H., Heshmat, Ramin, Hihtaniemi, Ilpo Tapani, Ho, Sai Yin, Ho, Suzanne C., Hobbs, Michael, Hofman, Albert, Hormiga, Claudia M., Horta, Bernardo L., Houti, Leila, Htay, Thein Thein, Htet, Aung Soe, Htike, Maung Maung Than, Hu, Yonghua, Hussieni, Abdullatif S., Huu, C. N., Huybrechts, Inge, Hwalla, Nahla, Iacoviello, Licia, Iannone, Anna G., Ibrahim, Mohsen M., Ikram, M. Arfan, Irazola, Vilma E., Islam, Muhammad, Iwasaki, Masanori, Jackson, Rod T., Jacobs, Jeremy M., Jafar, Tazeen, Jamil, Kazi M., Jamrozik, Konrad, Jasienska, Grazyna, Jiang, Chao Qiang, Joffres, Michel, Johansson, Mattias, Jonas, Jost B., Jorgensen, Torben, Joshi, Pradeep, Juolevi, Anne, Jurak, Gregor, Juresa, Vesna, Kaaks, Rudolf, Kafatos, Anthony, Kalter-Leibovici, Ofra, Kapantais, Efthymios, Kasaeian, Amir, Katz, Joanne, Kaur, Prabhdeep, Kavousi, Maryam, Keil, Ulrich, Boker, Lital Keinan, Kelishadi, Roya, Kemper, Han C. G., Kengne, Andre Pascal, Kersting, Mathilde, Key, Timothy, Khader, Yousef Saleh, Khalili, Davood, Khaw, Kay-Tee H., Khouw, Ilse M. S. L., Kiechl, Stefan, Killewo, Japhet, Kim, Jeongseon, Kiyohara, Yutaka, Klimont, Jeannette, Kolle, Elin, Kolsteren, Patrick, Korrovits, Paul, Koskinen, Seppo, Kouda, Katsuyasu, Koziel, Slawomir, Kratzer, Wolfgang, Krokstad, Steinar, Kromhout, Daan, Kruger, Herculina S., Kula, Krzysztof, Kulaga, Zbigniew, Kumar, R. Krishna, Kusuma, Yadlapalli S., Kuulasmaa, Kari, Laamiri, Fatima Zahra, Laatikainen, Tiina, Lachat, Carl, Laid, Youcef, Lam, Tai Hing, Landrove, Orlando, Lanska, Vera, Lappas, Georg, Laugsand, Lars E., Bao, K. Le Nguyen, Le, Tuyen D., Leclercq, Catherine, Lee, Jeannette, Lehtimaki, Terho, Lekhraj, Rampal, Leon-Munoz, Luz M., Lim, Wei-Yen, Lima-Costa, M. F., Lin, Xu, Linneberg, Allan, Lissner, Lauren, Litwin, Mieczyslaw, Liu, Jing, Lorbeer, Roberto, Lotufo, Paulo A., Lozano, J. E., Luksiene, Dalia, Lundqvist, Annamari, Lunet, Nuno, Lytsy, Per, Ma, Guansheng, Machi, Suka, Maggi, Stefania, Magliano, Dianna J., Makdisse, Marcia, Malekzadeh, Reza, Malhotra, Rahul, Rao, Kodavanti Mallikharjuna, Manios, Yannis, Mann, Jim I., Manzato, Enzo, Margozzini, Paula, Markey, Oonagh, Marques-Vidal, Pedro, Marrugat, Jaume, Martin-Prevel, Yves, Martorell, Reynaldo, Masoodi, Shariq R., Matsha, Tandi E., Mazur, Artur, Mbanya, Jean Claude N., McFarlane, Shelly R., McGarvey, Stephen T., McKee, Martin, McLachlan, Stela, McLean, Rachael M., McNulty, Breige A., Yusof, S. Md, Mediene-Benchekor, Sounnia, Meirhaeghe, Aline, Meisinger, Christa, Mendes, Larissa L., Menezes, Ana Maria B., Mensink, Gert B. M., Meshram, Indrapal I., Metspalu, Andres, Mi, Jie, Michaelsen, Kim F., Mikkel, Kairit, Miller, Jody C., Miquel, J. F., Misigoj-Durakovic, Marjeta, Mohamed, Mostafa K., Mohammad, Kazem, Mohammadifard, Noushin, Mohan, Viswanathan, Yusoff, Muhammad Fadhli Mohd, Molbo, Drude, Moller, Niels C., Molnar, Denes, Mondo, Charles K., Monterrubio, Eric A., Monyeki, Kotsedi Daniel K., Moreira, Leila B., Morejon, Alain, Moreno, Luis A., Morgan, Karen, Mortensen, Erik Lykke, Moschonis, George, Mossakowska, Malgorzata, Mota, Jorge, Motlagh, Mohammad Esmaeel, Motta, Jorge, Mu, Thet Thet, Muiesan, Maria Lorenza, Mueller-Nurasyid, Martina, Murphy, Neil, Mursu, Jaakko, Murtagh, Elaine M., Musa, Kamarul Imran, Musil, Vera, Nagel, Gabriele, Nakamura, Harunobu, Namesna, Jana, Nang, E. E. K., Nangia, Vinay B., Nankap, Martin, Narake, Sameer, Navarrete-Muñoz, E. M., Nenko, Ilona, Neovius, Martin, Nervi, Flavio, Neuhauser, Hannelore K., Nguyen, Nguyen D., Nieto-Martinez, Ramfis E., Ning, Guang, Ninomiya, Toshiharu, Nishtar, Sania, Noale, Marianna, Norat, Teresa, Noto, Davide, Nsour, Mohannad Al, O'Reilly, Dermot, Ochoa-Avilés, A. M., Oh, Kyungwon, Olayan, Iman H., Olinto, M. T. A., Oltarzewski, Maciej, Omar, Mohd A., Onat, Altan, Ordunez, Pedro, Ortiz, Ana P., Osler, Merete, Osmond, Clive, Ostojic, Sergej M., Otero, Johanna A., Overvad, Kim, Paccaud, Fred Michel, Padez, Cristina, Pajak, Andrzej, Palli, Domenico, Palloni, Alberto, Palmieri, Luigi, Panda-Jonas, Songhomitra, Panza, Francesco, Parnell, Winsome R., Parsaeian, Mahboubeh, Pednekar, Mangesh S., Peeters, Petra H., Peixoto, Sergio Viana, Pereira, Alexandre C., Perez, Cynthia M., Peters, Annette, Peykari, Niloofar, Pham, S. T., Pigeot, Iris, Pikhart, Hynek, Pilav, Aida, Pilotto, Lorenza, Pistelli, Francesco, Pitakaka, Freda, Piwonska, Aleksandra, Piwonski, J., Plans-Rubio, Pedro, Poh, Bee Koon, Porta, Miquel, Portegies, Marileen L. P., Poulimeneas, Dimitrios, Pradeepa, Rajendra, Prashant, Mathur, Price, Jacqueline F., Puiu, Maria, Punab, Margus, Qasrawi, Radwan F., Qorbani, Mostafa, Bao, T. Q., Radic, Ivana, Radisauskas, Ricardas, Rahman, Mahmudur, Raitakari, Olli, Raj, Manu, Rao, Sudha Ramachandra, Ramachandran, Ambady, Ramke, Jacqueline, Ramos, Rafel, Rampal, Sanjay, Rasmussen, Finn, Redon, Josep, Reganit, Paul Ferdinand M., Ribeiro, Robespierre, Riboli, Elio, Rigo, Fernando, Wit, Tobias Floris Rinke de, Ritti-Dias, Raphael M., Rivera, Juan A., Robinson, Sian M., Robitaille, Cynthia, Rodriguez-Artalejo, Fernando, Rodriguez-Perez, Maria del Cristo, Rodriguez-Villamizar, Laura A., Rojas-Martinez, Rosalba, Rojroongwasinkul, Nipa, Romaguera, Dora, Ronkainen, Kimmo, Rosengren, Annika, Rouse, Ian, Rubinstein, Adolfo, Ruhli, Frank J., Rui, Ornelas, Ruiz-Betancourt, B. S., Horimoto, Andrea R. V. Russo, Rutkowski, Marcin, Sabanayagam, Charumathi, Sachdev, Harshpal S., Saidi, Olfa, Salanave, Benoit, Martinez, E. S., Salomaa, Veikko, Salonen, Jukka T., Salvetti, Massimo, Sanchez-Abanto, Jose, Sandjaja, Sans, Susana, Santos, Diana A., Santos, Osvaldo, Santos, Renata Nunes dos, Santos, Rute, Sardinha, Luis B., Sarrafzadegan, Nizal, Saum, Kai-Uwe, Savva, Savvas C., Scazufca, Marcia, Rosario, Angelika Schaffrath, Schargrodsky, Herman, Schienkiewitz, Anja, Schmidt, Ida Maria, Schneider, Ione J., Schultsz, Constance, Schutte, Aletta E., Sein, Aye Aye, Sen, Abhijit, Senbanjo, Idowu O., Sepanlou, Sadaf G., Shalnova, Svetlana A., Shaw, Jonathan E., Shibuya, Kenji, Shin, Youchan, Shiri, Rahman, Siantar, Rosalynn, Sibai, Abla M., Silva, Antonio M., Silva, D. A. S., Simon, Mary, Simons, Judith, Simons, Leon A., Sjostrom, Michael, Slowikowska-Hilczer, Jolanta, Slusarczyk, Przemyslaw, Smeeth, Liam, Smith, Margaret C., Snijder, Marieke B., So, Hung-Kwan, Sobngwi, Eugene, Soderberg, Stefan, Soekatri, Moesijanti Y. E., Solfrizzi, Vincenzo, Sonestedt, Emily, Sorensen, Thorkild I. A., Soric, Maroje, Jerome, Charles Sossa, Soumare, Aicha, Staessen, Jan A., Starc, Gregor, Stathopoulou, Maria G., Staub, Kaspar, Stavreski, Bill, Steene-Johannessen, Jostein, Stehle, Peter, Stein, Aryeh D., Stergiou, George S., Stessman, Jochanan, Stieber, Jutta, Stöckl, D., Stocks, Tanja, Stokwiszewski, Jakub, Stratton, Gareth, Strufaldi, Maria Wany, Sun, C. A., Sundstroem, Johan, Sung, Y. T., Sunyer, Jordi, Suriyawongpaisal, Paibul, Swinburn, Boyd A., Sy, Rody G., Szponar, Lucjan, Tai, E. Shyong, Tammesoo, Mari-Liis, Tamosiunas, Abdonas, Tang, Line, Tang, Xun, Tanser, Frank, Tao, Yong, Tarawneh, Mohammed Rasoul, Tarp, Jakob, Tarqui-Mamani, Carolina B., Taylor, Anne, Tchibindat, Felicite, Thijs, Lutgarde, Thuesen, Betina H., Tjonneland, Anne, Tolonen, Hanna K., Tolstrup, Janne S., Topbas, Murat, Topor-Madry, Roman, Torrent, Maties, Traissac, Pierre, Trichopoulou, Antonia, Trichopoulos, Dimitrios, Trinh, Oanh T. 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Goya, Wareham, Nicholas, Weerasekera, Deepa, Whincup, Peter H., Widhalm, Kurt, Widyahening, Indah S., Wiecek, Andrzej, Wilks, Rainford J., Willeit, Johann, Wojtyniak, Bogdan, Wong, Jyh Eiin, Wong, Tien Yin, Woo, Jean, Woodward, Mark, Wu, Frederick C., Wu, Jianfeng, Wu, Shou Ling, Xu, Haiquan, Xu, Liang, Yamborisut, Uruwan, Yan, Weili, Yang, Xiaoguang, Yardim, Nazan, Ye, Xingwang, Yiallouros, Panayiotis K., Yoshihara, Akihiro, You, Qi Sheng, Younger-Coleman, Novie O., Yusoff, Ahmad F., Zainuddin, Ahmad A., Zambon, Sabina, Zdrojewski, Tomasz, Zeng, Yi, Zhao, Dong, Zhao, Wenhua, Zheng, Yingfeng, Zhou, Maigeng, Zhu, Dan, Zimmermann, Esther, Cisneros, Julio Zuniga, NCD Risk Factor Collaboration (NCD-RisC), Di Cesare, M., Bentham, J., Stevens, G.A., Zhou, B., Danaei, G., Lu, Y., Bixby, H., Cowan, M.J., Riley, L.M., Hajifathalian, K., Fortunato, L., Taddei, C., Bennett, J.E., Ikeda, N., Khang, Y.H., Kyobutungi, C., Laxmaiah, A., Li, Y., Lin, H.H., Miranda, J.J., Mostafa, A., Turley, M.L., 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TC, Costanzo C, Cottel D, Cowell C, Craig CL, Crujeiras AB, D'Arrigo G, d'Orsi E, Dallongeville J, Damasceno A, Damsgaard CT, Dankner R, Luc Dauchet L, De Backer G, De Bacquer D, de Gaetano G, De Henauw S, De Smedt D, Deepa M, Deev AD, Dehghan A, Delisle H, Delpeuch F, Dhana K, Di Castelnuovo AF, Dias-da-Costa JS, Diaz A, Djalalinia S, Do HTP, Dobson AJ, Donfrancesco C, Döring A, Doua K, Drygas W, Egbagbe EE, Eggertsen R, Ekelund U, El Ati J, Elliott P, Engle-Stone R, Erasmus RT, Erem C, Eriksen L, Escobedo-de la Peña J, Evans A, Faeh D, Fall CH, Farshad Farzadfar F, Felix-Redondo FJ, Ferguson TS, Fernández-Bergés D, Ferrante D, Ferrari M, Ferreccio C, Ferrieres J, Finn JD, Fischer K, Monterubio Flores E, Föger B, Foo LH, Forslund A-S, Fortmann SP, Fouad HM, Francis DK, Franco MdC, Franco OH, Guillermo Frontera G, Fuchs FH, Fuchs SC, Fujita Y, Furusawa T, Gaciong Z, Gafencu M, Gareta D, Garnett SP, Gaspoz J-M, GasulL M, Gates L, Geleijnse JM, Ghasemian A, Giampaoli S, GianfagnA F, 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Keinan Boker L, Kelishadi R, Kemper HHCG, Kengne AP, Kersting M, Key T, Khader YS, Khalili D, Khang Y-H, Kay-Tee H Khaw K-TH, Khouw LMSL, Kiechl S, Killewo J, Kim J, Kiyohara Y, Klimont J, Kolle E, Kolsteren P, Korrovits P, Koskinen S, Kouda K, Koziel S, Kratzer W, Krokstad S, Kromhout D, Kruger HS, Kula K, Kulaga Z, Kumar RK, Kusuma YS, Kuulasmaa K, Laamiri FZ, Laatikainen T, Lachat C, Laid Y, Lam TH, Landrove O, Lanska V, Lappas G, Laugsand LE, Nguyen Bao KL, Le TD, Leclercq C, Lee J, Jeonghee Lee J, Lehtimäki T, Lekhraj R, León-Muñoz LM, Lim W-Y, M Fernanda Lima-Costa MF, Lin H-H, Lin X, Linneberg A, Lissner L, Litwin M, Liu J, Lorbeer R, Lotufo PA, Lozano JE, Luksiene D, Lundqvist A, Lunet N, Lytsy P, Ma G, Machi S, Maggi S, Magliano DJ, Makdisse M, Malekzadeh R, Malhotra R, Mallikharjuna Rao K, Manios Y, Mann JI, Manzato E, Margozzini P, Markey O, Marques-Vidal P, Marrugat P, Martin-Prevel Y, Martorell R, Masoodi SR, Matsha TE, Mazur A, Mbanya JCN, McFarlane SR, McGarvey ST, McKee M, McLachlan S, McLean RM, McNulty BA, Md Yusof S, Mediene-Benchekor S, Meirhaeghe A, Meisinger A, Mendes LL, Menezes AMB, Mensink GBM, Meshram II, Metspalu A, Mi JM, Michaelsen KF, Miller JC, Miquel JF, Mišigoj-Duraković M, Mohamed MK, Mohammad K, Mohammadifard N, Mohan V, Mohd Yusoff MF, Molbo D, Møller NC, Molnár D, Mondo CK, Monterrubio EA, Monyeki KDK, Leila B Moreira LB, Morejon A, Moreno LA, Morgan K, Mortensen EL, Moschonis G, Mossakowska M, Mota J, Motlagh ME, Motta J, Mu TT, Muiesan ML, Müller-Nurasyid M, Murphy N, Mursu J, Murtagh EM, Musa KI, Musil V, Nagel G, Nakamura H, Námešná J, Nang EEK, Nangia VB, Nankap M, Narake S, Navarrete-Muñoz EM, Nenko I, Neovius M, Nervi F, Neuhauser HK, Nguyen ND, Ngoc Nguyen Q, Nieto-Martínez RE, Ning G, Ninomiya T, Nishtar S, Noale M, Norat T, Noto D, Al Nsour M, O'Reilly D, Ochoa-Avilés AM, Oh K, Olayan IH, Olinto MTA, Oltarzewski M, Omar MA, Onat A, Ordunez P, Ortiz AP, Osler M, Osmond C, Ostojic AM, Otero JA, Overvad K, Paccaud F, Padez C, Pajak A, Palli D, Palloni A, Palmieri L, Panda-Jonas S, Panza F, Parnell WR, Parsaeian M, Pednekar MS, Peeters PH, Peixoto SV, Pereira AC, Pérez CM, Peters A, Peykari N, Pham ST, Pigeot I, Pikhart H, Pilav A, Pilotto L, Pistelli F, Pitakaka F, Piwonska A, Piwonski J, Pedro Plans-Rubió P, Poh BK, Porta M, Portegies MLP, Poulimeneas D, Pradeepa R, Prashant M, Price JF, Puiu M, Punab M, Qasrawi RF, Qorbani M, Quoc Bao T, Radic I, Ricardas Radisauskas R, Rahman M, Raitakari O, Raj M, Ramachandra Rao S, Ramachandran A, Ramke J, Ramos R, Rampal S, Rasmussen F, Redon J, Reganit PFM, Robespierre Ribeiro R, Riboli E, Rigo F, Rinke de Wit TF, Ritti-Dias RM, Juan A Rivera JA, Robinson SM, Robitaille C, Rodríguez-Artalejo F, Rodriguez-Perez MdC, Rodríguez-Villamizar LA, Rojas-Martinez R, Rojroongwasinkul N, Romaguera D, Ronkainen K, Rosengren A, Rouse I, Rubinstein A, Rühli FJ, Rui O, Ruiz-Betancourt BS, Russo Horimoto ARV, Rutkowski M, Sabanayagam C, Sachdev HS, Saidi O, Salanave B, Salazar Martinez E, Salomaa V, Salonen JT, Salvetti M, Sánchez-Abanto J, Sandjaja A, Sans S, Santos DA, Santos O, dos Santos RN, Santos R, Sardinha LB, Sarrafzadegan N, Saum K-U, Savva SC, Scazufca M, Schaffrath Rosario A, Schargrodsky H, Schienkiewitz A, Schmidt IM, Schneider IJ, Schultsz C, Schutte AE, Sein AA, Sen A, Senbanjo IO, Sepanlou SG, Shalnova SA, Shaw JE, Shibuya K, Shin Y, Shiri R, Siantar R, Sibai AM, Silva AM, Simon M, Simons J, Simons LA, Sjostrom M, Slowikowska-Hilczer J, Slusarczyk P, Smeeth L, Smith MC, Snijder MB, So H-K, Sobngwi E, Söderberg S, Soekatri MYE, Solfrizzi V, Sonestedt E, Sørensen TIA, Sorić M, Sossa Jérome C, Soumare A, Staessen JA, Starc G, Stathopoulou MG, Staub K, Stavreski B, Steene-Johannessen J, Stehle P, Stein AD, Stergiou GS, Stessman J, Stieber J, Stöckl D, Stocks T, Stokwiszewski J, Stratton G, Strufaldi MW, Chien-An Sun C-A, Sundström J, Sung Y-T, Sunyer J, Suriyawongpaisal P, Swinburn BA, Sy RG, Szponar L, E Shyong Tai E, Tammesoo M-L, Tamosiunas A, Tang L, Tang X, Tanser F, Tao Y, Tarawneh M, Jakob Tarp J, Tarqui-Mamani CB, Taylor A, Félicité Tchibindat F, Thijs L, Thuesen BH, Tjonneland A, Tolonen HK, Janne S Tolstrup JS, Topbas M, Topór-Madry R, Torrent M, Traissac P, Trichopoulos D, Trinh OTH, Trivedi A, Tshepo L, Tulloch-Reid MK, Tuomainen T-P, Tuomilehto J, Tynelius P, Tzotzas T, Tzourio C, Ueda P, Ukoli FAM, Ulmer H, Unal B, Valdivia G, Susana Va S, Valvi D, van der Schouw YT, Van Herck K, Van Minh H, van Valkengoed IGM, Vanderschueren D, Vanuzzo D, Vatten L, Vega T, Velasquez-Melendez G, Veronesi G, Verschuren WMM, Viegi G, Viet L, Viikari-Juntura E, Vineis P, Vioque P, Virtanen JK, Visvikis-Siest S, Viswanathan B, Vollenweider P, Voutilainen S, Vrijheid M, Wade AN, Wagner A, Walton J, Wan Mohamud WN, Wang M-D, Wang Q, Wang YX, Wannamethee SG, Wareham N, Deepa Weerasekera D, Whincup PH, Widhalm K, Widyahening IS, Wiecek A, Wilks RJ, Willeit J, Wojtyniak B, Wong, Wong TY, Woo J, Woodward M, Wu FC, JianFeng Wu JF, Wu SL, Xu H, Xu L, Yamborisut U, Yan W, Yang X, Yardim N, Ye X, Yiallouros PK, Yoshihara A, Qi Sheng You QS, Younger-Coleman NO, Yusoff AF, Ahmad A Zainuddin AA, Zambon S, Zdrojewski T, Zeng Y, Zhao D, Zhao W, Zheng Y, Zhou M, Zhu D, Zimmermann E, Zuñiga Cisneros J, General Internal Medicine, AII - Amsterdam institute for Infection and Immunity, Public and occupational health, Global Health, and APH - Amsterdam Public Health

Subjects
Male, Obesidad, CHILDREN, Salud, Review, países desarrollados, Global Health, Body Mass Index, Body mass index, population study, 0302 clinical medicine, Models, Factores de riesgo cardiovascular, Medicine, body mass index, underweight, overweight, obesity, Young adult, Human Nutrition & Health, education.field_of_study, Humane Voeding & Gezondheid, General Medicine, ASSOCIATION, 11 Medical And Health Sciences, adulto, predicción, adulto joven, CARDIOVASCULAR-DISEASE, thinness/epidemiology, NONCOMMUNICABLE DISEASES, NCD Risk Factor Collaboration (NCD-RisC), Enfermedades cardiovasculares, Developed country, teorema de Bayes, Medical sciences, 03 medical and health sciences, SDG 3 - Good Health and Well-being, Thinness, Humans, education, Developing Countries, obesidad, VLAG, Science & Technology, Models, Statistical, CAUSE-SPECIFIC MORTALITY, Bayes Theorem, medicine.disease, QP, Obesity, adult body-mass, Indice de masa corporal (IMC), RISK-FACTORS, Adolescent, Adult, Developed Countries, Female, Forecasting, Obesity/epidemiology, Prevalence, Thinness/epidemiology, Young Adult, RA, Body mass index, Demography, Meta-Analysis, Gerontology, Settore MED/09 - Medicina Interna, Nutrition and Disease, humanos, adolescente, Overweight, países en desarrollo, Voeding en Ziekte, Medicine and Health Sciences, Global health, 030212 general & internal medicine, Non-U.S. Gov't, Medicine (all), Research Support, Non-U.S. Gov't, prevalencia, Public Health, Global Health, Social Medicine and Epidemiology, Statistical, Underweight, medicine.symptom, pooled analysis, Life Sciences & Biomedicine, obesity/*epidemiology, Population, 030209 endocrinology & metabolism, Research Support, Medicine, General & Internal, EPIDEMIC, General & Internal Medicine, Journal Article, Life Science, ddc:610, Obesidad morbida, OBESITY PREVENTION, OVERWEIGHT, business.industry, índice de masa corporal, COHORTS, purl.org/pe-repo/ocde/ford#3.02.00 [https], Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi, Ciencias socio biomédicas, business, delgadez
Abstract

Copyright © NCD Risk Factor Collaboration. Open Access article distributed under the terms of CC BY., Background: Underweight and severe and morbid obesity are associated with highly elevated risks of adverse health outcomes. We estimated trends in mean body-mass index (BMI), which characterises its population distribution, and in the prevalences of a complete set of BMI categories for adults in all countries. Methods: We analysed, with use of a consistent protocol, population-based studies that had measured height and weight in adults aged 18 years and older. We applied a Bayesian hierarchical model to these data to estimate trends from 1975 to 2014 in mean BMI and in the prevalences of BMI categories (, Wellcome Trust, Grand Challenges Canada

Published
2016
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23. Pancreatic β-Cells and Type 2 Diabetes Development

Author

Alarcon-Aguilar, Miranda-Perez Maria Elizabeth, Escobar-Villanueva, Ortega-Camarillo Clara, J Francisco, and Maria Del Carmen

Subjects
0301 basic medicine, medicine.medical_specialty, endocrine system diseases, Endocrinology, Diabetes and Metabolism, medicine.medical_treatment, Disease, Type 2 diabetes, 03 medical and health sciences, Endocrinology, Internal medicine, Diabetes mellitus, Insulin-Secreting Cells, Insulin Secretion, Medicine, Animals, Humans, Insulin, Epigenetics, Obesity, chemistry.chemical_classification, Reactive oxygen species, business.industry, Regeneration (biology), medicine.disease, Endoplasmic Reticulum Stress, Pathophysiology, Islet Amyloid Polypeptide, Mitochondria, 030104 developmental biology, chemistry, Diabetes Mellitus, Type 2, Hyperglycemia, business
Abstract

Diabetes mellitus (DM) is a group of metabolic disorders characterized by hyperglycemia. In particular, type 2 diabetes (T2D) represents one of the main causes of death in the world, and those suffering from it have a lower quality of life. Although there are multiple hypotheses about the pathophysiological mechanisms that lead to the development of T2D, the effects of this pathology on pancreatic β-cells are often ignored. We now know that in addition to genetic defects, β-cell organellar dysfunction participates in the earliest stages of the disease; other factors also contribute to this dysfunction, such as excessive production of reactive oxygen species and a decrease in cellular volume and mass. These features usually result from increased apoptosis, which is not adequately compensated for by the characteristic regeneration mechanisms of these cells. In this study, we specifically examine the genetic, epigenetic and metabolic defects that contribute to β-cell dysfunction and lead to the establishment of T2D, particularly the dysregulated insulin synthesis and secretion in these cells.

Published
2015

24. Effects of diabetes definition on global surveillance of diabetes prevalence and diagnosis: a pooled analysis of 96 population-based studies with 331 288 participants

Author

Danaei, Goodarz, Fahimi, Saman, Lu, Yuan, Zhou, Bin, Hajifathalian, Kaveh, Di Cesare, Mariachiara, Lo, Wei-Cheng, Reis-Santos, Barbara, Cowan, Melanie J., Shaw, Jonathan E., Bentham, James, Lin, John K., Bixby, Honor, Magliano, Dianna, Bovet, Pascal, Miranda, J. Jaime, Khang, Young-Ho, Stevens, Gretchen A., Riley, Leanne M., Ali, Mohammed K., Ezzati, Majid, Abdeen, Ziad A., Kadir, Khalid Abdul, Abu-Rmeileh, Niveen M., Acosta-Cazares, Benjamin, Aekplakorn, Wichai, Aguilar-Salinas, Carlos A., Ahmadvand, Alireza, Al Nsour, Mohannad, Alkerwi, Ala'a, Amouyel, Philippe, Andersen, Lars Bo, Anderssen, Sigmund A., Andrade, Dolores S., Anjana, Ranjit Mohan, Aounallah-Skhiri, Hajer, Aris, Tahir, Arlappa, Nimmathota, Arveiler, Dominique, Assah, Felix K., Avdicova, Maria, Balakrishna, Nagalla, Bandosz, Piotr, Barbagallo, Carlo M., Barcelo, Alberto, Batieha, Anwar M., Baur, Louise A., Ben Romdhane, Habiba, Bernabe-Ortiz, Antonio, Bhargava, Santosh K., Bi, Yufang, Bjerregaard, Peter, Bjorkelund, Cecilia, Blake, Margaret, Blokstra, Anneke, Bo, Simona, Boehm, Bernhard O., Boissonnet, Carlos P., Brajkovich, Imperia, Breckenkamp, Juergen, Brewster, Lizzy M., Brian, Garry R., Bruno, Graziella, Bugge, Anna, de Leon, Antonio Cabrera, Can, Gunay, Candido, Ana Paula C., Capuano, Vincenzo, Carvalho, Maria J., Casanueva, Felipe F., Caserta, Carmelo A., Castetbon, Katia, Chamukuttan, Snehalatha, Chaturvedi, Nishi, Chen, Chien-Jen, Chen, Fangfang, Chen, Shuohua, Cheng, Ching-Yu, Chetrit, Angela, Chiou, Shu-Ti, Cho, Yumi, Chudek, Jerzy, Cifkova, Renata, Claessens, Frank, Concin, Hans, Cooper, Cyrus, Cooper, Rachel, Costanzo, Simona, Cottel, Dominique, Cowell, Chris, Crujeiras, Ana B., D'Arrigo, Graziella, Dallongeville, Jean, Dankner, Rachel, Dauchet, Luc, de Gaetano, Giovanni, De Henauw, Stefaan, Deepa, Mohan, Dehghan, Abbas, Dhana, Klodian, Di Castelnuovo, Augusto F., Djalalinia, Shirin, Doua, Kouamelan, Drygas, Wojciech, Du, Yong, Egbagbe, Eruke E., Eggertsen, Robert, El Ati, Jalila, Elosua, Roberto, Erasmus, Rajiv T., Erem, Cihangir, Ergor, Gul, Eriksen, Louise, la Penaa, Jorge Escobedo-De, Fall, Caroline H., Farzadfar, Farshad, Felix-Redondo, Francisco J., Ferguson, Trevor S., Fernandez-Berges, Daniel, Ferrari, Marika, Ferreccio, Catterina, Finn, Joseph D., Foger, Bernhard, Foo, Leng Huat, Fouad, Heba M., Francis, Damian K., Franco, Maria do Carmo, Franco, Oscar H., Frontera-Juan, Guillem, Furusawa, Takuro, Gaciong, Zbigniew, Galbarczyk, Andrzej, Garnett, Sarah P., Gaspoz, Jean-Michel, Gasull, Magda, Gates, Louise, Geleijnse, Johanna M., Ghasemain, Anoosheh, Giampaoli, Simona, Gianfagna, Francesco, Giovannelli, Jonathan, Gross, Marcela Gonzalez, Rivas, Juan P. Gonzalez, Gorbea, Mariano Bonet, Gottrand, Frederic, Grant, Janet F., Grodzicki, Tomasz, Grontved, Anders, Gruden, Grabriella, Gu, Dongfeng, Guan, Ong Peng, Guerrero, Ramiro, Guessous, Idris, Guimaraes, Andre L., Gutierrez, Laura, Hardy, Rebecca, Kumar, Rachakulla Hari, He, Jiang, Heidemann, Christin, Hihtaniemi, Ilpo Tapani, Ho, Sai Yin, Ho, Suzanne C., Hofman, Albert, Russo, Andrea R. V., Hormiga, Claudia M., Horta, Bernardo L., Houti, Leila, Hussieni, Abdullatif S., Huybrechts, Inge, Hwalla, Nahla, Iacoviello, Licia, Iannone, Anna G., Ibrahim, Mohsen M., Ikeda, Nayu, Ikram, M. Arfan, Irazola, Vilma E., Islam, Muhammad, Iwasaki, Masanori, Jacobs, Jeremy M., Jafar, Tazeen, Jasienska, Grazyna, Jiang, Chao Qiang, Jonas, Jost B., Joshi, Pradeep, Kafatos, Anthony, Kalter-Leibovici, Ofra, Kasaeian, Amir, Katz, Joanne, Kaur, Prabhdeep, Kavousi, Maryam, Kelishadi, Roya, Kengne, Andre P., Kersting, Mathilde, Khader, Yousef Saleh, Kiechl, Stefan, Kim, Jeongseon, Kiyohara, Yutaka, Kolsteren, Patrick, Korrovits, Paul, Koskinen, Seppo, Kratzer, Wolfgang, Kromhout, Daan, Kula, Krzysztof, Kurjata, Pawel, Kyobutungi, Catherine, Lachat, Carl, Laid, Youcef, Lam, Tai Hing, Landrove, Orlando, Lanska, Vera, Lappas, Georg, Laxmaiah, Avula, Leclercq, Catherine, Lee, Jeannette, Lee, Jeonghee, Lehtimaki, Terho, Lekhraj, Rampal, Leon-Munoz, Luz M., Li, Yanping, Lim, Wei-Yen, Lima-Costa, M. Fernanda, Lin, Hsien-Ho, Lin, Xu, Lissner, Lauren, Lorbeer, Roberto, Lozano, Jose Eugenio, Lundqvist, Annamari, Lytsy, Per, Ma, Guansheng, Machado-Coelho, George L. 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E., Ning, Guang, Ninomiya, Toshiharu, Noale, Marianna, Noto, Davide, Ochoa-Aviles, Angelica M., Oh, Kyungwon, Onat, Altan, Osmond, Clive, Otero, Johanna A., Palmieri, Luigi, Panda-Jonas, Songhomitra, Panza, Francesco, Parsaeian, Mahboubeh, Peixoto, Sergio Viana, Pereira, Alexandre C., Peters, Annette, Peykari, Niloofar, Pilav, Aida, Pitakaka, Freda, Piwonska, Aleksandra, Piwonski, Jerzy, Plans-Rubio, Pedro, Porta, Miquel, Portegies, Marileen L. P., Poustchi, Hossein, Pradeepa, Rajendra, Price, Jacqueline F., Punab, Margus, Qasrawi, Radwan F., Qorbani, Mostafa, Raitakari, Olli, Rao, Sudha Ramachandra, Ramachandran, Ambady, Ramos, Rafel, Rampal, Sanjay, Rathmann, Wolfgang, Redon, Josep, Reganit, Paul Ferdinand M., Rigo, Fernando, Robinson, Sian M., Robitaille, Cynthia, Rodriguez, Laura A., Rodriguez-Artalejo, Fernando, Rodriguez-Perez, Maria del Cristo, Rojas-Martinez, Rosalba, Romaguera, Dora, Rosengren, Annika, Rubinstein, Adolfo, Rui, Ornelas, Ruiz-Betancourt, Blanca Sandra, Rutkowski, Marcin, Sabanayagam, Charumathi, Sachdev, Harshpal S., Saidi, Olfa, Sakarya, Sibel, Salanave, Benoit, Salonen, Jukka T., Salvetti, Massimo, Sanchez-Abanto, Jose, Nunes, Renata, Santos, Rute, Sardinha, Luis B., Scazufca, Marcia, Schargrodsky, Herman, Scheidt-Nave, Christa, Shibuya, Kenji, Shin, Youchan, Shiri, Rahman, Siantar, Rosalynn, Sibai, Abla M., Simon, Mary, Simons, Judith, Simons, Leon A., Sjostrom, Michael, Slowikowska-Hilczer, Jolanta, Slusarczyk, Przemyslaw, Smeeth, Liam, Snijder, Marieke B., Solfrizzi, Vincenzo, Sonestedt, Emily, Soumare, Aicha, Staessen, Jan A., Steene-Johannessen, Jostein, Stehle, Peter, Stein, Aryeh D., Stessman, Jochanan, Stockl, Doris, Stokwiszewski, Jakub, Strufaldi, Maria Wany, Sun, Chien-An, Sundstrom, Johan, Suriyawongpaisal, Paibul, Sy, Rody G., Tai, E. Shyong, Tarawneh, Mohammed, Tarqui-Mamani, Carolina B., Thijs, Lutgarde, Tolstrup, Janne S., Topbas, Murat, Torrent, Maties, Traissac, Pierre, Trinh, Oanh T. H., Tulloch-Reid, Marshall K., Tuomainen, Tomi-Pekka, Turley, Maria L., Tzourio, Christophe, Ueda, Peter, Ukoli, Flora M., Ulmer, Hanno, Valdivia, Gonzalo, Van Valkengoed, Irene G. M., Vanderschueren, Dirk, Vanuzzo, Diego, Vega, Tomas, Velasquez-Melendez, Gustavo, Veronesi, Giovanni, Verschuren, Monique, Vioque, Jesus, Virtanen, Jyrki, Visvikis-Siest, Sophie, Viswanathan, Bharathi, Vollenweider, Peter, Voutilainen, Sari, Wade, Alisha N., Wagner, Aline, Walton, Janette, Mohamud, Wan Nazaimoon Wan, Wang, Ming-Dong, Wang, Ya Xing, Wannamethee, S. Goya, Weerasekera, Deepa, Whincup, Peter H., Widhalm, Kurt, Wiecek, Andrzej, Wilks, Rainford J., Willeit, Johann, Wojtyniak, Bogdan, Wong, Tien Yin, Woo, Jean, Woodward, Mark, Wu, Aleksander Giwercman, Wu, Frederick C., Wu, Shou Ling, Xu, Haiquan, Yang, Xiaoguang, Ye, Xingwang, Yoshihara, Akihiro, Younger-Coleman, Novie O., Zambon, Sabina, Zargar, Abdul Hamid, Zdrojewski, Tomasz, Zhao, Wenhua, Zheng, Yingfeng, NCD Risk Factor Collaboration (NCD-RisC), Epidemiology, Radiology & Nuclear Medicine, General Internal Medicine, Landsteiner Laboratory, APH - Amsterdam Public Health, Public and occupational health, Danaei, Goodarz, Fahimi, Saman, Lu, Yuan, Zhou, Bin, Hajifathalian, Kaveh, Cesare, Mariachiara Di, Lo, Wei-Cheng, Reis-Santos, Barbara, Cowan, Melanie J., Shaw, Jonathan E., Bentham, Jame, Lin, John K., Bixby, Honor, Magliano, Dianna, Bovet, Pascal, Miranda, J. Jaime, Khang, Young-Ho, Stevens, Gretchen A., Riley, Leanne M., Ali, Mohammed K., Ezzati, Majid, Kadir, Khalid Abdul, Abu-Rmeileh, Niveen M, Acosta-Cazares, Benjamin, Aekplakorn, Wichai, Aguilar-Salinas, Carlos A., Ahmadvand, Alireza, Nsour, Mohannad Al, Alkerwi, Ala'a, Amouyel, Philippe, Andersen, Lars Bo, Anderssen, Sigmund A., Andrade, Dolores S., Anjana, Ranjit Mohan, Aounallah-Skhiri, Hajer, Aris, Tahir, Arlappa, Nimmathota, Arveiler, Dominique, Assah, Felix K., Avdicová, Mária, Balakrishna, Nagalla, Bandosz, Piotr, Barbagallo, Carlo M., Alberto Barceló, null, Batieha, Anwar M., Baur, Louise A., Romdhane, Habiba Ben, Bernabe-Ortiz, Antonio, Bhargava, Santosh K., Bi, Yufang, Bjerregaard, Peter, Björkelund, Cecilia, Blake, Margaret, Blokstra, Anneke, Bo, Simona, Boehm, Bernhard O., Boissonnet, Carlos P., Brajkovich, Imperia, Breckenkamp, Juergen, Brewster, Lizzy M., Brian, Garry R., Bruno, Graziella, Bugge, Anna, de León, Antonio Cabrera, Can, Gunay, Cândido, Ana Paula C, Capuano, Vincenzo, Carvalho, Maria J., Casanueva, Felipe F., Caserta, Carmelo A., Castetbon, Katia, Chamukuttan, Snehalatha, Chaturvedi, Nishi, Chen, Chien-Jen, Chen, Fangfang, Chen, Shuohua, Cheng, Ching-Yu, Chetrit, Angela, Chiou, Shu-Ti, Cho, Yumi, Chudek, Jerzy, Cifkova, Renata, Claessens, Frank, Concin, Han, Cooper, Cyru, Cooper, Rachel, Costanzo, Simona, Cottel, Dominique, Cowell, Chri, Crujeiras, Ana B., D'Arrigo, Graziella, Dallongeville, Jean, Dankner, Rachel, Dauchet, Luc, de Gaetano, Giovanni, de Henauw, Stefaan, Deepa, Mohan, Dehghan, Abba, Dhana, Klodian, Di Castelnuovo, Augusto F., Djalalinia, Shirin, Doua, Kouamelan, Drygas, Wojciech, Du, Yong, Egbagbe, Eruke E., Eggertsen, Robert, Ati, Jalila El, Elosua, Roberto, Erasmus, Rajiv T., Erem, Cihangir, Ergor, Gul, Eriksen, Louise, Escobedo-de la Peña, Jorge, Fall, Caroline H., Farzadfar, Farshad, Felix-Redondo, Francisco J., Ferguson, Trevor S., Fernández-Bergés, Daniel, Ferrari, Marika, Ferreccio, Catterina, Finn, Joseph D., Föger, Bernhard, Foo, Leng Huat, Fouad, Heba M., Francis, Damian K., do Carmo Franco, Maria, Franco, Oscar H., Frontera, Guillermo, Furusawa, Takuro, Gaciong, Zbigniew, Galbarczyk, Andrzej, Garnett, Sarah P., Gaspoz, Jean-Michel, Gasull, Magda, Gates, Louise, Geleijnse, Johanna M., Ghasemain, Anoosheh, Giampaoli, Simona, Gianfagna, Francesco, Giovannelli, Jonathan, Gross, Marcela Gonzalez, González Rivas, Juan P., Gorbea, Mariano Bonet, Gottrand, Frederic, Grant, Janet F., Grodzicki, Tomasz, Grøntved, Ander, Gruden, Grabriella, Gu, Dongfeng, Guan, Ong Peng, Guerrero, Ramiro, Guessous, Idri, Guimaraes, Andre L., Gutierrez, Laura, Hardy, Rebecca, Kumar, Rachakulla Hari, He, Jiang, Heidemann, Christin, Hihtaniemi, Ilpo Tapani, Ho, Sai Yin, Ho, Suzanne C., Hofman, Albert, Russo Horimoto, Andrea R.V., Hormiga, Claudia M., Horta, Bernardo L., Houti, Leila, Hussieni, Abdullatif S., Huybrechts, Inge, Hwalla, Nahla, Iacoviello, Licia, Iannone, Anna G., Ibrahim, Mohsen M., Ikeda, Nayu, Ikram, Arfan M., Irazola, Vilma E., Islam, Muhammad, Iwasaki, Masanori, Jacobs, Jeremy M., Jafar, Tazeen, Jasienska, Grazyna, Jiang, Chao Qiang, Jonas, Jost B., Joshi, Pradeep, Kafatos, Anthony, Kalter-Leibovici, Ofra, Kasaeian, Amir, Katz, Joanne, Kaur, Prabhdeep, Kavousi, Maryam, Kelishadi, Roya, Kengne, Andre P., Kersting, Mathilde, Khader, Yousef Saleh, Kiechl, Stefan, Kim, Jeongseon, Kiyohara, Yutaka, Kolsteren, Patrick, Korrovits, Paul, Koskinen, Seppo, Kratzer, Wolfgang, Kromhout, Daan, Kula, Krzysztof, Kurjata, Pawel, Kyobutungi, Catherine, Lachat, Carl, Laid, Youcef, Lam, Tai Hing, Landrove, Orlando, Lanska, Vera, Lappas, Georg, Laxmaiah, Avula, Leclercq, Catherine, Lee, Jeannette, Lee, Jeonghee, Lehtimäki, Terho, Lekhraj, Rampal, León-Muñoz, Luz M., Li, Yanping, Lim, Wei-Yen, Fernanda Lima-Costa, M., Lin, Hsien-Ho, Lin, Xu, Lissner, Lauren, Lorbeer, Roberto, Lozano, José Eugenio, Lundqvist, Annamari, Lytsy, Per, Ma, Guansheng, Machado-Coelho, George L.L., Machi, Suka, Maggi, Stefania, Makdisse, Marcia, Rao, Kodavanti Mallikharjuna, Manios, Yanni, Manzato, Enzo, Margozzini, Paula, Marques-Vidal, Pedro, Martorell, Reynaldo, Masoodi, Shariq R., Matsha, Tandi E., Mbanya, Jean Claude N., McFarlane, Shelly R., McGarvey, Stephen T., McLachlan, Stela, McNulty, Breige A., Mediene-Benchekor, Sounnia, Meirhaeghe, Aline, Menezes, Ana Maria B., Merat, Shahin, Meshram, Indrapal I., Mi, Jie, Miquel, Juan Francisco, Mohamed, Mostafa K., Mohammad, Kazem, Mohan, Viswanathan, Yusoff, Muhammad Fadhli Mohd, Moller, Niels C., Molnar, Dene, Mondo, Charles K., Moreno, Luis A., Morgan, Karen, Moschonis, George, Mossakowska, Malgorzata, Mostafa, Aya, Mota, Jorge, Muiesan, Maria L., Müller-Nurasyid, Martina, Mursu, Jaakko, Nagel, Gabriele, Namesna, Jana, Nang, Ei Ei K., Nangia, Vinay B., Navarrete-Muñoz, Eva Maria, Ndiaye, Ndeye Coumba, Nervi, Flavio, Nguyen, Nguyen D., Nieto-Martínez, Ramfis E., Ning, Guang, Ninomiya, Toshiharu, Noale, Marianna, Noto, Davide, Ochoa-Avilés, Angélica M., Oh, Kyungwon, Onat, Altan, Osmond, Clive, Otero, Johanna A., Palmieri, Luigi, Panda-Jonas, Songhomitra, Panza, Francesco, Parsaeian, Mahboubeh, Peixoto, Sergio Viana, Pereira, Alexandre C., Peters, Annette, Peykari, Niloofar, Pilav, Aida, Pitakaka, Freda, Piwonska, Aleksandra, Piwonski, Jerzy, Plans-Rubió, Pedro, Porta, Miquel, Portegies, Marileen L.P., Poustchi, Hossein, Pradeepa, Rajendra, Price, Jacqueline F., Punab, Margu, Qasrawi, Radwan F., Qorbani, Mostafa, Raitakari, Olli, Rao, Sudha Ramachandra, Ramachandran, Ambady, Ramos, Rafel, Rampal, Sanjay, Rathmann, Wolfgang, Redon, Josep, Reganit, Paul Ferdinand M., Rigo, Fernando, Robinson, Sian M., Robitaille, Cynthia, Rodríguez, Laura A., Rodríguez-Artalejo, Fernando, Rodriguez-Perez, María del Cristo, Rojas-Martinez, Rosalba, Romaguera, Dora, Rosengren, Annika, Rubinstein, Adolfo, Rui, Ornela, Ruiz-Betancourt, Blanca Sandra, Rutkowski, Marcin, Sabanayagam, Charumathi, Sachdev, Harshpal S., Saidi, Olfa, Sakarya, Sibel, Salanave, Benoit, Salonen, Jukka T., Salvetti, Massimo, Sánchez-Abanto, Jose, dos Santos, Renata Nune, Santos, Rute, Sardinha, Luis B., Scazufca, Marcia, Schargrodsky, Herman, Scheidt-Nave, Christa, Shibuya, Kenji, Shin, Youchan, Shiri, Rahman, Siantar, Rosalynn, Sibai, Abla M., Simon, Mary, Simons, Judith, Simons, Leon A., Sjostrom, Michael, Slowikowska-Hilczer, Jolanta, Slusarczyk, Przemyslaw, Smeeth, Liam, Snijder, Marieke B., Solfrizzi, Vincenzo, Sonestedt, Emily, Soumare, Aicha, Staessen, Jan A., Steene-Johannessen, Jostein, Stehle, Peter, Stein, Aryeh D., Stessman, Jochanan, Stöckl, Dori, Stokwiszewski, Jakub, Strufaldi, Maria Wany, Sun, Chien-An, Sundström, Johan, Suriyawongpaisal, Paibul, Sy, Rody G., Tai, E Shyong, Tarawneh, Mohammed, Tarqui-Mamani, Carolina B., Thijs, Lutgarde, Tolstrup, Janne S., Topbas, Murat, Torrent, Matie, Traissac, Pierre, Trinh, Oanh T.H., Tulloch-Reid, Marshall K., Tuomainen, Tomi-Pekka, Turley, Maria L., Tzourio, Christophe, Ueda, Peter, Ukoli, Flora M., Ulmer, Hanno, Valdivia, Gonzalo, van Valkengoed, Irene G.M., Vanderschueren, Dirk, Vanuzzo, Diego, Vega, Toma, Velasquez-Melendez, Gustavo, Veronesi, Giovanni, Verschuren, Monique, Vioque, Jesu, Virtanen, Jyrki, Visvikis-Siest, Sophie, Viswanathan, Bharathi, Vollenweider, Peter, Voutilainen, Sari, Wade, Alisha N., Wagner, Aline, Walton, Janette, Mohamud, Wan Nazaimoon Wan, Wang, Ming-Dong, Wang, Ya Xing, Wannamethee, S Goya, Weerasekera, Deepa, Whincup, Peter H., Widhalm, Kurt, Wiecek, Andrzej, Wilks, Rainford J., Willeit, Johann, Wojtyniak, Bogdan, Wong, Tien Yin, Woo, Jean, Woodward, Mark, Wu, Aleksander Giwercman, Wu, Frederick C., Wu, Shou Ling, Xu, Haiquan, Yang, Xiaoguang, Ye, Xingwang, Yoshihara, Akihiro, Younger-Coleman, Novie O., Zambon, Sabina, Zargar, Abdul Hamid, Zdrojewski, Tomasz, Zhao, Wenhua, Zheng, Yingfeng, and Wellcome Trust

Subjects
Male, endocrine system diseases, Endocrinology, Diabetes and Metabolism, medicine.medical_treatment, Global Health, 0302 clinical medicine, Endocrinology, education.field_of_study, Diabetis, purl.org/pe-repo/ocde/ford#3.02.18 [https], Diabetes Mellitus/blood/diagnosis/epidemiology, Sciences bio-médicales et agricoles, adulto, sensibilidad y especificidad, health survey, 3. Good health, priority journal, CARDIOVASCULAR-DISEASE, diabetes mellitus, medicine.medical_specialty, glucosa sanguínea, Survey sampling, oral glucose tolerance test, Medical sciences, Sensitivity and Specificity, Article, Internal Medicine, Effects of diabetes, Hemoglobin A, Glycosylated/metabolism, 03 medical and health sciences, false positive result, SDG 3 - Good Health and Well-being, Diabetes prevalence, Diabetes Mellitus, SYSTEMATIC ANALYSIS, Humans, human, diagnostic test accuracy study, gross national product, OLDER-ADULTS, education, prueba de tolerancia a la glucosa, glycosylated hemoglobin, HEMOGLOBIN A(1C) MEASUREMENT, VLAG, Glycated Hemoglobin, Hemoglobin A, Glycosylated, Science & Technology, Blood Glucose/metabolism, nutritional and metabolic diseases, Glucose Tolerance Test, economic aspect, medicine.disease, glucose blood level, Glucose, age, chemistry, Faculdade de Ciências Sociais, Glucosa, Global surveillance of diabetes, TOLERANCE TEST, WORLDWIDE STANDARDIZATION, Biomarkers, Biomedical sciences, Blood Glucose, Settore MED/09 - Medicina Interna, Nutrition and Disease, humanos, Biomarkers/metabolism, geography, chemistry.chemical_compound, Voeding en Ziekte, Diagnosis, Prevalence, Medicine and Health Sciences, vigilancia centinela, 030212 general & internal medicine, hemoglobin A1c, US POPULATION, Diabetes diagnosis, Glucose tolerance test, INSULIN-RESISTANCE, medicine.diagnostic_test, Research Support, Non-U.S. Gov't, Diabetes, prevalencia, SCREENING-TEST, health, Articles, Glucose blood, Diabetes and Metabolism, income, Population-based health examination surveys, Female, Life Sciences & Biomedicine, Adult, Population, population group, CONSENSUS STATEMENT, 030209 endocrinology & metabolism, GLYCATED HEMOGLOBIN, high income region, Endocrinology & Metabolism, Insulin resistance, Research Support, N.I.H., Extramural, blood, Internal medicine, Diabetes mellitus, parasitic diseases, Journal Article, medicine, Life Science, ddc:613, business.industry, Insulin, body mass, Biological marker, FASTING PLASMA-GLUCOSE, Ciencias socio biomédicas, Glycated hemoglobin, business, metabolism, Sentinel Surveillance
Abstract

Diabetes has been defined on the basis of different biomarkers, including fasting plasma glucose (FPG), 2-h plasma glucose in an oral glucose tolerance test (2hOGTT), and HbA1c. We assessed the effect of different diagnostic definitions on both the population prevalence of diabetes and the classification of previously undiagnosed individuals as having diabetes versus not having diabetes in a pooled analysis of data from population-based health examination surveys in different regions., 0, info:eu-repo/semantics/published

Published
2015
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25. FACTORES RELACIONADOS CON LA COLONOSCOPIA INCOMPLETA: PAPEL DE LA COLONOGRAFIA POR TOMOGRAFIA COMPUTERIZADA (TC) COMO PRUEBA COMPLEMENTARIA A LA COLONOSCOPIA CONVENCIONAL

Author

P Latorre Año, I Ortiz Polo, J Martinez Perez Maria, A. López Serrano, I Ferrando Marrades, B. Solaz Garrido, V.J. Morales Alvarado, G Vidal Iniesta, Eduardo Moreno-Osset, Anton Conejero, and M Paredes Arquiola Jose

Subjects
Gynecology, medicine.medical_specialty, business.industry, Gastroenterology, medicine, business
Abstract

Introduccion: La colonoscopia tiene un importante papel en la deteccion del cancer colorrectal (CCR). El fracaso en la intubacion cecal acontece entre 2 – 23% de las colonoscopias. La Colonografia por TC (CTC) puede permitir la completa exploracion del colon, conocer con mas precision la causa de colonoscopia incompleta (CI) y valorar posibles lesiones significativas en el tramo de colon no explorado. Objetivo: Identificar causas de CI y describir el tipo de lesiones encontradas en el colon mediante el uso de CTC, asi como su seguridad. Material y Metodo: Estudio descriptivo retrospectivo de casos con CI y a los que se realizo una CTC posterior. Se obtuvieron datos de la historia clinica y de las bases de datos del Area de Endoscopias y del Servicio de Radiologia. Resultados: Desde Enero-2010 hasta Abril-2013 se incluyeron 105 pacientes: 63 hombres (60,0%) y 42 mujeres (40,0%); edad media 66,8 (limites: 39 – 89) anos. El 38,1% tenian antecedentes de cirugia abdominal, el 17,1% cirugia ginecologica. Principales indicaciones de colonoscopia: sospecha de CCR (33,3%), hemorragia digestiva baja (20,4%) y anemia ferropenica (11,1%). El tramo mas proximal explorado por la colonoscopia fue: recto (9,5%), sigma (50,5%), colon descendente (12,4%), angulo esplenico (3,8%), colon transverso (10,5%), angulo hepatico (9,5%) y colon ascendente (3,8%). Causas frecuentes de CI: CCR obstructivo (52,8%), estenosis benigna (9,4%) principalmente secundaria a diverticulitis (6,6%), y factores anatomicos (8,5%). Lesiones detectadas en la CTC: polipos (34,7%), lesiones estenosantes malignas (28,5%), diverticulosis (9,5%) y lesiones estenosantes benignas (4,5%). En 2 pacientes (1,9%) se detecto CCR en el tramo no explorado por la colonoscopia convencional. Conclusiones: La causa mas frecuente de CI fue CCR obstructivo. La CTC es una herramienta util y segura para completar el estudio del colon en pacientes con CI previa. La CTC detecta lesiones clinicamente importantes que pueden modificar el plan quirurgico del paciente.

Published
2013
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26. Influence of sex steroids on sclerostin levels in patients with prostate cancer

Author

Mariela Varsavsky, Dolores Aviles-Perez Maria, Rebeca Reyes-García, Antonia García-Martín, Beatriz García-Fontana, Sonia Morales-Santana, and Manuel Muñoz-Torres

Subjects
Oncology, medicine.medical_specialty, business.industry, General Medicine, medicine.disease, Prostate cancer, chemistry.chemical_compound, Endocrinology, chemistry, Internal medicine, Medicine, Sclerostin, In patient, business
Published
2013
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27. Integrated curriculum design: Outcomes of a two-week Spanish intensive course for nursing students

Author

Pérez, María E.

Subjects
Language. Linguistic theory. Comparative grammar, P101-410, Business, HF5001-6182
Abstract

This article analyzes the outcomes of an intensive Spanish course for nursing students of various Spanish language abilities. The course objectives were to enable the students to conduct a nursing assessment interview and data gathering in Spanish, as well as providing instructions and recording information for vital signs and a head-to-toe physical exam. Treating these interactions as standard communicative frames, utilizing Goffman’s (1974) schema, guided the course development. Vocabulary and grammar were restricted to the needs of the assigned tasks, and concentrated on speaking and receptive abilities, not on writing or reading. The course was successful in achieving the stated course objectives, and students demonstrated basic communication skills and the ability to perform the assigned tasks in Spanish at the end of the course.

Published
2020
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28. Training in small business retailing: testing human capital theory

Author

Barcala, Marta Fernandez, Perez, Maria Jose Sanzo, and Gutierrez, Juan Antonio Trespalacios

Subjects
Human capital -- Research, Occupational training -- Models, Retail industry -- Training, Small business -- Training, Business, Business, international
Published
1999

29. 'New Japan' is threat to U.S. apparel marketers

Author

Pysarchik, Dawn Thorndike and Perez, Maria E.

Subjects
Clothing industry -- Marketing, Corporations -- Marketing, Corporations, Korean -- Marketing, Advertising, marketing and public relations, Business
Abstract

Low-wage countries such as South Korea pose a major challenge to US apparel marketers. According to U.S. Industrial Outlook 1988, South Korea produced 12.5% of the $125 billion worth of apparel purchased by US consumers in 1988. A survey of 40 US and 23 South Korean apparel companies showed that US manufacturers 'weakly agreed' that their main problem is low-cost imported apparel. Results also indicated that US manufacturers realize they cannot rely on protectionist measures. Instead, US companies can grow and expand to foreign markets by taking advantage of product quality; design expertise; brand-name recognition; rapid delivery; and marketing capabilities.

Published
1989

30. Is there any place for PD-1/CTLA-4 inhibitors combination in the first-line treatment of advanced NSCLC?—A trial-level meta-analysis in PD-L1 selected subgroups

Author

Antonio Russo, Valerio Gristina, Francesco Passiglia, Marta Castiglia, Antonio Galvano, Maria La Mantia, Alessandro Perez, Viviana Bazan, Nadia Barraco, and Francesco Passiglia, Antonio Galvano, Valerio Gristina, Nadia Barraco, Marta Castiglia, Alessandro Perez, Maria La Mantia, Antonio Russo, Viviana Bazan

Subjects
Oncology, medicine.medical_specialty, programmed death-1/cytotoxic T-lymphocyte antigen 4 inhibitors (PD-1/CTLA-4 inhibitors), combined modality therapy, business.industry, Hazard ratio, Combined modality therapy, Immunotherapy, Meta-analysis, Non-small cell lung cancer (NSCLC), Programmed death-1/cytotoxic T-lymphocyte antigen 4 inhibitors (PD-1/CTLA-4 inhibitors), non-small cell lung cancer (NSCLC), medicine.disease, law.invention, Discontinuation, meta-analysis, Randomized controlled trial, law, Relative risk, Internal medicine, Medicine, Original Article, immunotherapy, business, Lung cancer, Adverse effect
Abstract

BACKGROUND: The advent of immuno-oncology (IO) represented a breakthrough in non-small cell lung cancer (NSCLC) therapy over the last few years. However, establishing the optimal therapeutic options among programmed death-ligand 1 (PD-L1) selected subgroups still addresses an unmet need in the clinical setting. METHODS: We performed a systematic review and finally included eleven first-line randomized controlled trials to compare efficacy and safety outcomes among first-line IO treatment strategies versus standard platinum-based chemotherapy (CT) according to PD-L1 expression level (

Published
2021

31. Worldwide trends in hypertension prevalence and progress in treatment and control from 1990 to 2019: a pooled analysis of 1201 population-representative studies with 104 million participants

Author

Zhou, B, Carrillo-Larco, Rm, Danaei, G, Riley, Lm, Paciorek, Cj, Stevens, Ga, Gregg, Ew, Bennett, Je, Solomon, B, Singleton, Rk, Sophiea, Mk, Iurilli, Mlc, Lhoste, Vpf, Cowan, Mj, Savin, S, Woodward, M, Balanova, Y, Cifkova, R, Damasceno, A, Elliott, P, Farzadfar, F, He, J, Ikeda, N, Kengne, Ap, Khang, Yh, Kim, Hc, Laxmaiah, A, Lin, Hh, Maira, Pm, Miranda, Jj, Neuhauser, H, Sundstrom, J, Varghese, C, Widyahening, Is, Zdrojewski, T, Ezzati, M, Abarca-Gomez, L, Abdeen, Za, Rahim, Hfa, Abu-Rmeileh, Nm, Acosta-Cazares, B, Adams, Rj, Aekplakorn, W, Afsana, K, Afzal, S, Agdeppa, Ia, Aghazadeh-Attari, J, Aguilar-Salinas, Ca, Agyemang, C, Ahmad, Na, Ahmadi, A, Ahmadi, N, Ahmadizar, F, Ahmed, Sh, Ahrens, W, Ajlouni, K, Al-Raddadi, R, Alarouj, M, Albuhairan, F, Aldhukair, S, Ali, Mm, Alkandari, A, Alkerwi, A, Allin, K, Aly, E, Amarapurkar, Dn, Amougou, N, Amouyel, P, Andersen, Lb, Anderssen, Sa, Anjana, Rm, Ansari-Moghaddam, A, Ansong, D, Aounallah-Skhiri, H, Araujo, J, Ariansen, I, Aris, T, Arku, Re, Arlappa, N, Aryal, Kk, Aspelund, T, Assah, Fk, Assuncao, Mcf, Auvinen, J, Avdicova, M, Azevedo, A, Azimi-Nezhad, M, Azizi, F, Azmin, M, Babu, Bv, Bahijri, S, Balakrishna, N, Bamoshmoosh, M, Banach, M, Banadinovic, M, Bandosz, P, Banegas, Jr, Baran, J, Barbagallo, Cm, Barcelo, A, Barkat, A, Barreto, M, Barros, Ajd, Barros, Mvg, Bartosiewicz, A, Basit, A, Bastos, Jld, Bata, I, Batieha, Am, Batyrbek, A, Baur, La, Beaglehole, R, Belavendra, A, Ben Romdhane, H, Benet, M, Benson, Ls, Berkinbayev, S, Bernabe-Ortiz, A, Bettiol, H, Bezerra, J, Bhagyalaxmi, A, Bhargava, Sk, Bia, D, Biasch, K, Lele, Ecb, Bikbov, Mm, Bista, B, Bjerregaard, P, Bjertness, E, Bjertness, Mb, Bjorkelund, C, Bloch, Kv, Blokstra, A, Bo, S, Bobak, M, Boeing, H, Boggia, Jg, Boissonnet, Cp, Bojesen, Se, Bongard, V, Bonilla-Vargas, A, Bopp, M, Borghs, H, Bovet, P, Boyer, Cb, Braeckman, L, Brajkovich, I, Branca, F, Breckenkamp, J, Brenner, H, Brewster, Lm, Briceno, Y, Brito, M, Bruno, G, Bueno-de-Mesquita, Hb, 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Kazakbaeva, Ulrich Keil, Lital Keinan Boker, Sirkka Keinänen-Kiukaanniemi, Roya Kelishadi, Han Cg Kemper, Maryam Keramati, Alina Kerimkulova, Mathilde Kersting, Timothy Key, Yousef Saleh Khader, Davood Khalili, Kay-Tee Khaw, Bahareh Kheiri, Motahareh Kheradmand, Alireza Khosravi, Ursula Kiechl-Kohlendorfer, Stefan Kiechl, Japhet Killewo, Dong Wook Kim, Jeongseon Kim, Heidi Klakk, Magdalena Klimek, Jurate Klumbiene, Michael Knoflach, Elin Kolle, Patrick Kolsteren, Jukka P Kontto, Raija Korpelainen, Paul Korrovits, Jelena Kos, Seppo Koskinen, Katsuyasu Kouda, Sudhir Kowlessur, Slawomir Koziel, Jana Kratenova, Vilma Kriaucioniene, Peter Lund Kristensen, Steiner Krokstad, Daan Kromhout, Herculina S Kruger, Ruzena Kubinova, Renata Kuciene, Urho M Kujala, Zbigniew Kulaga, R Krishna Kumar, Pawel Kurjata, Yadlapalli S Kusuma, Vladimir Kutsenko, Kari Kuulasmaa, Catherine Kyobutungi, Tiina Laatikainen, Carl Lachat, Youcef Laid, Tai Hing Lam, Orlando Landrove, Vera Lanska, Georg Lappas, Bagher Larijani, Tint Swe Latt, Gwenaëlle Le Coroller, Khanh Le Nguyen Bao, Tuyen D Le, Jeannette Lee, Jeonghee Lee, Nils Lehmann, Terho Lehtimäki, Daniel Lemogoum, Naomi S Levitt, Yanping Li, Christa L Lilly, Wei-Yen Lim, M Fernanda Lima-Costa, Xu Lin, Yi-Ting Lin, Lars Lind, Vijaya Lingam, Allan Linneberg, Lauren Lissner, Mieczyslaw Litwin, Wei-Cheng Lo, Helle-Mai Loit, Esther Lopez-Garcia, Tania Lopez, Paulo A Lotufo, José Eugenio Lozano, Iva Lukačević Lovrenčić, Janice L Lukrafka, Dalia Luksiene, Annamari Lundqvist, Robert Lundqvist, Nuno Lunet, Michala Lustigová, Edyta Luszczki, Guansheng Ma, Jun Ma, George Ll Machado-Coelho, Aristides M Machado-Rodrigues, Enguerran Macia, Luisa M Macieira, Ahmed A Madar, Stefania Maggi, Dianna J Magliano, Emmanuella Magriplis, Gowri Mahasampath, Bernard Maire, Marjeta Majer, Marcia Makdisse, Fatemeh Malekzadeh, Reza Malekzadeh, Rahul Malhotra, Kodavanti Mallikharjuna Rao, Sofia K Malyutina, Lynell V Maniego, Yannis Manios, Jim I Mann, Fariborz 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Subjects
Male, Latin Americans, Nutrition and Disease, Epidemiology, [SDV]Life Sciences [q-bio], Medizin, BLOOD-PRESSURE, 030204 cardiovascular system & hematology, Worldwide trends in hypertension prevalence and progress in treatment and control from 1990 to 2019: a pooled analysis of 1201 population-representative studies with 104 million participants, Hypertension, Prevalence, Control, Tretament, GUIDELINES, Global Health, Worldwide trends, 0302 clinical medicine, Hypertension prevalence, Voeding en Ziekte, Medicine and Health Sciences, kohonnut verenpaine, Medicine, 030212 general & internal medicine, Prevention and Control, 11 Medical and Health Sciences, ComputingMilieux_MISCELLANEOUS, education.field_of_study, food and beverages, Public Health, Global Health, Social Medicine and Epidemiology, General Medicine, Noncommunicable diseases, Period prevalence, Middle Aged, kansainvälinen vertailu, 3142 Public health care science, environmental and occupational health, 3. Good health, MIDDLE-INCOME, Pooled analysis, SYSTEMATIC ANALYSIS, INCOME COUNTRIES, ADULTS, PREVENTION, MANAGEMENT, ADHERENCE, DIAGNOSIS, Western europe, [SDE]Environmental Sciences, Hypertension/diagnosis, NCD Risk Factor Collaboration (NCD-RisC), Female, B990 Subjects Allied to Medicine not elsewhere classified, Life Sciences & Biomedicine, Adult, health-care, esiintyvyys, Central asia, Population, Nursing, 3121 Internal medicine, 03 medical and health sciences, Medicine, General & Internal, Drug Therapy, General & Internal Medicine, Life Science, Humans, ddc:610, education, Antihypertensive Agents, VLAG, Aged, Science & Technology, Antihypertensive Agents/therapeutic use, business.industry, Omvårdnad, fungi, General and internal medicine, Estados de Saúde e de Doença, Taking medication, Treatment, Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi, Blood pressure, Faculdade de Ciências Sociais, 3121 General medicine, internal medicine and other clinical medicine, lääkehoito, 1182 Biochemistry, cell and molecular biology, business, Demography
Abstract

Background: hypertension can be detected at the primary health-care level and low-cost treatments can effectively control hypertension. We aimed to measure the prevalence of hypertension and progress in its detection, treatment, and control from 1990 to 2019 for 200 countries and territories. Methods: we used data from 1990 to 2019 on people aged 30-79 years from population-representative studies with measurement of blood pressure and data on blood pressure treatment. We defined hypertension as having systolic blood pressure 140 mm Hg or greater, diastolic blood pressure 90 mm Hg or greater, or taking medication for hypertension. We applied a Bayesian hierarchical model to estimate the prevalence of hypertension and the proportion of people with hypertension who had a previous diagnosis (detection), who were taking medication for hypertension (treatment), and whose hypertension was controlled to below 140/90 mm Hg (control). The model allowed for trends over time to be non-linear and to vary by age. Findings: the number of people aged 30-79 years with hypertension doubled from 1990 to 2019, from 331 (95% credible interval 306-359) million women and 317 (292-344) million men in 1990 to 626 (584-668) million women and 652 (604-698) million men in 2019, despite stable global age-standardised prevalence. In 2019, age-standardised hypertension prevalence was lowest in Canada and Peru for both men and women; in Taiwan, South Korea, Japan, and some countries in western Europe including Switzerland, Spain, and the UK for women; and in several low-income and middle-income countries such as Eritrea, Bangladesh, Ethiopia, and Solomon Islands for men. Hypertension prevalence surpassed 50% for women in two countries and men in nine countries, in central and eastern Europe, central Asia, Oceania, and Latin America. Globally, 59% (55-62) of women and 49% (46-52) of men with hypertension reported a previous diagnosis of hypertension in 2019, and 47% (43-51) of women and 38% (35-41) of men were treated. Control rates among people with hypertension in 2019 were 23% (20-27) for women and 18% (16-21) for men. In 2019, treatment and control rates were highest in South Korea, Canada, and Iceland (treatment >70%; control >50%), followed by the USA, Costa Rica, Germany, Portugal, and Taiwan. Treatment rates were less than 25% for women and less than 20% for men in Nepal, Indonesia, and some countries in sub-Saharan Africa and Oceania. Control rates were below 10% for women and men in these countries and for men in some countries in north Africa, central and south Asia, and eastern Europe. Treatment and control rates have improved in most countries since 1990, but we found little change in most countries in sub-Saharan Africa and Oceania. Improvements were largest in high-income countries, central Europe, and some upper-middle-income and recently high-income countries including Costa Rica, Taiwan, Kazakhstan, South Africa, Brazil, Chile, Turkey, and Iran. Interpretation Improvements in the detection, treatment, and control of hypertension have varied substantially across countries, with some middle-income countries now outperforming most high-income nations. The dual approach of reducing hypertension prevalence through primary prevention and enhancing its treatment and control is achievable not only in high-income countries but also in low-income and middle-income settings., British Heart Foundation Centre of Research Excellence Grant; World Health Organization (WHO); Abdul Latif Jameel Institute for Disease and Emergency Analytics Fellowship

Published
2021
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32. Post-anaesthesia pulmonary complications after use of muscle relaxants (POPULAR): a multicentre, prospective observational study

Author

Kirmeier E. a, Eriksson L. I. c, Lewald H. a, Jonsson Fagerlund, M. c Hoeft, A. f Hollmann, M. g Meistelman, C. e Hunter, J. M. d Ulm, K. b Blobner, M. aEmail Author, Abad Gurumeta, A. Abernethy, C. Abigail, P. Achaibar, K. Adam, E. Afshari, Agudelo Montoya, M. E. Akgün, F. N. Aletti, G. Alkış, N. Allan, K. Allan, A. Allaouchiche, B. Allcock, C. Almasy, E. Amey, I. Amigoni, M. Andersen, E. Andersson, P. Anipchenko, N. Antunes, P. Armstrong, E. Aslam, T. N. Aslin, B. Assunção, J. P. Ausserer, J. Avvai, M. Awad, Ayas Montero, B. Ayuso, M. Azevedo, P. Badarau, V. Badescu, Baiardo Redaelli, M. Baird, C. Baird, Y. Baker, T. Balaji, P. Bălan, C. Balandin, A. Balescu-Arion, C. Baliuliene, Baltasar Isabel, J. Baluch, S. N. Bandrabur, D. Bankewitz, C. Barber, K. Barbera, F. Barcraft-Barnes, H. Barletti, V. Barnett, G. Baron, K. Barros, A. Barsan, V. Bartlett, P. Batistaki, C. Baumgarten, G. Baytas, V. Beauchamp, Becerra Cayetano, I. A. Bell, S. Bellandi, M. Belletti, Belmonte Cuenca, J. Benitez-Cano, A. Beretta, L. Berger, M. Bergmann, N. Bergmark, Bermudez Lopez, M. Bernotaite, M. Beurskens, C. Bidd, H. Bifulco, F. Bignami, E. Bilic, A. Bilskiene, D. Bischoff, P. Bishop, L. Bjonness, T. Blaylock, H. Blethyn, K. Blincoe, T. Blokhin, I. Blunt, N. Boer, C. Bois, G. Bonicolini, E. Booth, J. Borecka-Kedzierska, M. Borstnar, K. Borys, M. Boselli, E. Bouvet, L. Bouwman, A. Bowen, L. Bowrey, S. Boxall, L. Božić, T. Bradley, T. Branco, T. Brazzi, L. Brazzoni, M. Brear, T. Brogly, N. Brohi, F. Broms, J. Bubliauskas, A. Bucolo, G. E. Buerkle, H. Buggy, D. Buhre, W. Bukauskas, T. Butturini, F. Byttner, Cabrera Díaz, I. Calderon, A. Calhau, R. Callejo, A. Cammu, G. Campesato, M. Can, Ö. S. Candeias, M. Cantor, A. Carise, E. Carmona, C. Carreteiro, J. Carrieri, C. Carter, A. Casal, M. Casanova, I. Cascella, M. Casero, L. M. Casiraghi, G. M. Castelo-Branco, Castro Arranz, C. Cernea, D. D. Cervantes, J. Chandler, B. Charnock, R. Chatzimicali, A. Chinery, E. Chishti, A. 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Ali, Hussein, Ahmed, Hyams, Benjamin, Iannuccelli, Fabrizio, Ilette, Katie, Ilyas, Carl, Inan, Turgay, India, Immaculada, Ionițăv, Victor, Irwin, Foo, Jain, Vipul, Janez, Benedikt, Jankovic, Radmilo, Jenkins, Sarah, Jenko, Matej, Jimenez, Raquel, Jiménez Gomez, Bárbara, Joachim, Sugganthi, Joelsson-Alm, Eva, John, John, Jonikaite, Lina, Jovic, Miomir, Jungwirth, Bettina, Junke, Etienne, Kabakov, Bory, Kadaoui, Salah-Din, Kanski, Andrzej, Karadag, Süheyla, Karbonskiene, Aurika, Karjagin, Juri, Kasnik, Darja, Katanolli, Fato, Katsika, Eleni, Kaufmann, Kai, Keane, Helen, Kelly, Martin, Kent, Melanie, Keraitiene, Grazina, Khudhur, Ahmed, Khuenl-Brady, Karin, Kidd, Laurie, King, Siobhan, Kirchgäßner, Katharina, Klancir, Tino, Klucniks, Andri, Knotzer, Johann, Knowlden, Peter, Koers, Lena, Kompan, Janez, Koneti, Kiran K, Kooij, Fabian, Koolen, Eric, Koopman - van Gemert, Anna Wilhelmina Margaretha Maria, Kopp, Kristen, Korfiotis, Dimitrio, Korolkov, Oleg, Kosinová, Martina, Köstenberger, Marku, Kotzinger, Oskar, Kovačević, Marko, Kranke, Peter, Kranke, Eva, Kraus, Christiane, Kraus, Stephanie, Kubitzek, Christiane, Kucharski, Rafal, Kucukguclu, Semih, Kudrashou, Allaksandr, Kumar, Vinayak, Kummen, Live, Kunit, Cornelia, Kushakovsky, Vlad, Kuvaki, Bahar, Kuzmanovska, Biljana, Kyttari, Aikaterina, Landoni, Giovanni, Lau, Gary, Lazarev, Konstantin, Legett, Samantha, Legrottaglie, Anna Maria, Leonardi, Silvia, Leong, Maria, Lercher, Helene, Leuvrey, Matthieu, Leva, Brigitte, Levstek, Meta, Limb, Jame, Lindholm, Espen, Linton, Fiona, Liperi, Corradero, Lipski, Fabian, Lirk, Philipp, Lisi, Alberto, Lišková, Katarina, Lluch Oltra, Aitana, Loganathan, Vinothan, Lombardi, Stefania, Lopez, Eloisa, Lopez Rodríguez, Maria, Lorenzini, Laura, Lowicka, Malgorzata, Lugovoy, Alexander, Luippold, Madeleine, Lumb, Andrew, Macas, Andriu, Macgregor, Mark, Machado, Humberto, Maciariello, Maria, Madeira, Isabel, Maitan, Stefan, Majewski, Jacek, Maldini, Branka, Malewski, Georgia, Manfredini, Livia, Männer, Olja, Marchand, Bahareh, Marcu, Alexandra, Margalef, Jordi, Margarson, Michael, Marinheiro, Lucia, Markic, Ana, Markovic Bozic, Jasmina, Marrazzo, Francesco, Martin, Jane, Martin Ayuso, Maria, Martinez, Esteher, Martino, Enrico Antonio, Martinson, Victoria, Marusic-Gaser, Katarina, Mascarenhas, Catia, Mathis, Cindy, Matsota, Paraskevi, Mavrommati, Eleni, Mazul Sunko, Branka, McCourt, Killian, McGill, Neil, McKee, Raymond, Meço, Başak Ceyda, Meier, Sonja, Melbourne, Susan, Melbybråthen, Grethe, Meli, Andrea, Melia, Aiden, Melotti, Rita Maria, Menga, Maria Rosaria, Mercer, Pauline, Merotra, Susan, Mescolini, Silvia, Metterlein, Thoma, Michalov, Martin, Michlig, Sam, Midgley, Susan, Milić, Morena, Milojevic, Milan, Miñana, Amanda, Minto, Gary, Mirabella, Lucia, Mirea, Liliana, Mittelstädt, Ludger, Moeglen, Aude, Moise, Alida, Mokini, Zhirajr, Molin, Anna, Moltó, Lui, Monea, Maria Concetta, Montalto, Francesca, Montgomery, Jane, Montgomery, Claire, Montillo, Gerardo, Moore, Sally, Moore, Faye, Moreira, Zelia, Moreno, Tania, Moreno, Ricardo, Moret, Enrique, Moreton, Sarah, Morgan, Marianne, Moro Velasco, Concepción, Morri, Davide, Moull, Alice, Moura, Fernando, Mráz, Peter, Mrozek, Katarzyna, Mukhtar, Karim, Muniyappa, Sudeshkumar, Murray, Heather, Murthy, Burra VS, Mushambi, Mary, Nadolski, Maria, Nardelli, Pasquale, Nardin, Giordano, Navarro Pérez, Rosalía, Naveiro, Andrea, Negri, Manuela, Nesek Adam, Visnja, Neskovic, Vojislava, Neuwersch, Stefan, Neves, Miriam, Nguyen, Bavinh, Ní Eochagáin, Aisling, Nicholas, Caroline, Nightingale, Jeremy, Norrie, Kylie, Novak-Jankovic, Vesna, Novakova, Andrea, Novillo, Marta, Numan, Sandra, Oduro-Dominah, Louise, Oldner, Ander, Oliveira, Isabel, Ologoiu, Daniela, Oloktsidou, Irini, O'Reilly, Rosalind, Orlando, Alessandro, Ovezov, Alexey, Ozbilgin, Sule, Paal, Peter, Padin Barreiro, Lidia, Palugniok, Ryszard, Papaioannou, Alexandra, Papapostolou, Konstantino, Paranthaman, Prabhakar, Pardey Bracho, Gilda, Parente, Suzana, Parfeni, Alexandru, Pasin, Laura, Passey, Samuel, Pastor, Ernesto, Patch, Sarah, Patil, Andan, Paunescu, Marilena-Alina, Pehboeck, Daniel, Pereira, Manuela, Pereira, Carla, Perez Caballero, Paula, Pérez García, Aníbal, Pérez Soto, Antonia, Perez Tejero, Gisela, Perez-Cerda, Francisco, Pesenti, Antonio, Petta, Rocco, Philippe, Simon, Pickering, David, Pico Veloso, Jandro, Pina, Pedro, Pinho-Oliveira, Vítor, Pinol, Santiago, Pinto, Rita, Pistidda, Laura, Pitterle, Manuela, Piwowarczyk, Paweł, Plotnikova, Olga, Pohl, Holger, Poldermann, Jorinde, Polkovicová, Lucia, Pompei, Livia, Popescu, Mihai, Popović, Radmila, Pota, Vincenzo, Potocnik, Miriam, Potręć, Beata, Potter, Alison, Pramod, Nalwaya, Prchalova, Martina, Preckel, Benedikt, Pugh, Richard, Pulletz, Mark, Radoeshki, Aleksandar, Rafi, Amir, Ragazzi, Riccardo, Raineri Santi, Maurizio, Rajamanickam, Tamiselvan, Rajput, Zahra, Ramachandran, Rajeskar, Ramasamy, Radhika, Ramessur, Suneil, Rao, Roshan, Rasmussen, Ander, Rato, André, Razaque, Usman, Real Navacerrada, M. Isabel, Reavley, Caroline, Reid, Jame, Reschreiter, Henrik, Rial, Erick, Ribas Carrasco, Patricia, Ribeiro, Sandy, Rich, Nathalie, Richardson, Lydia, Rimaitis, Kestuti, Rimaitis, Mariu, Ringvold, Else-Marie, Ripke, Fabian, Ristescu, Irina, Ritchie, Keith, Ródenas, Frederic, Rodrigues, Patrícia, Rogers, Emma, Rogerson, David, Romagnoli, Stefano, Romero, Esther, Rondovic, Goran, Rose, Bernd Oliver, Roth, Winfried, Rotter, Marie-Therese, Rousseau, Guy, Rudjord, Ander, Rueffert, Henrik, Rundgren, Malin, Rupprecht, Korbinian, Rushton, Andrew, Russotto, Vincenzo, Rypulak, Elżbieta, Ryszka, Maciej, Sà, Jacinta, Sà Couto, Paula, Saby, Sandrine, Sagic, Jelena, Saleh, Omar, Sales, Gabriele, Sánchez Sánchez, Yván, Sanghera, Sumayer, Şanli Karip, Ceren, Santiveri Papiol, Francisco Javier, Santos, Sofia, Sarno, Stephen, Saul, Daniel, Saunders, David, Savic, Nenad, Scalco, Loïc, Scanlon, Deborah, Schaller, Stefan, Schax, Christoph, Scheffer, Gert Jan, Schening, Anna, Schiavone, Vincenzo, Schmidt-Ehrenberg, Florian, Schmidt-Mutter, Catherine, Schönberg, Christina, Schopflin, Christian, Schreiber, Jan-Uwe, Schultz, Marcu, Schurig, Marlen, Scott, Carmen, Sebestian, Siby, Sehgal, Selena, Sem, Victoria, Semenas, Egidiju, Serafini, Elena, Serchan, Pashalitsa, Shields, Martin, Shobha, Ramakrishnan, Shosholcheva, Mirjana, Siamansour, Tanja, Siddaiah, Narendra, Siddiqi, Khalid, Sinclair, Rhona, Singh, Permendra, Singh, Rajendra, Sinha, Aneeta, Sinha, Ashok, Skinner, Amanda, Smee, Elizabeth, Smekalova, Olga, Smith, Neil, Smith, Thoma, Smitz, Carine, Smole, Daniel, Sojčić, Nataša, Soler Pedrola, Maria, Somanath, Sameer, Sonksen, Julian, Sorella, Maria Christina, Sörmus, Alar, Soro, Marina, Soto, Carmen, Spada, Anna, Spadaro, Savino, Spaeth, Johanne, Sparr, Harald, Spielmann, Annika, Spindler-Vesel, Alenka, Stamelos, Matthaio, Stancombe L, Liucia, Stanculescu, Andreea, Standl, Thoma, Standley, Tom, Stanek, Ondrej, Stanisavljević, Snežana, Starczewska, Malgorzata, Stäuble, Christiane, Steen, Julie, Stefan, Oana Maria, Stell, Elizabeth, Stera, Caterina, Stevens, Marku, Stoerckel, Marlène, Stošić, Biljana, Stourac, Petr, Stroumpoulis, Konstantino, Struck, Rafael, Suarez de la Rica, Alejandro, Sultanpori, Altaf, Sundara Rajan, Rajinikanth, Suying, Ong, Svensen, Christer, Swan, Louise, Syrogianni, Paulina, Sysiak, Justyna, Szederjesi, Jano, Taddei, Stefania, Tan Hao, Ern, Tanou, Virginia, Tarabová, Katarina, Tardaguila Sancho, Paula, Tarroso, Maria, Tartaglione, Marco, Taylor, Emma, Tbaily, Lee, Telford, Richard, Terenzoni, Massimo, Theodoraki, Kassiani, Thornley, Helen, Tiganiuc, Liviu, Toim, Hardo, Tomescu, Dana, Tommasino, Concezione, Toni, Jessica, Toninelli, Arturo, Toretti, Ilaria, Townley, Stephen, Trepenaitis, Dariu, Trethowan, Brian, Tsaousi, Georgia, Tsiftsi, Aikaterini, Tudor, Adrada, Turan, Güldem, Turhan, Sanem Çakar, Unic-Stojanovic, Dragana, Unterbuchner, Christoph, Unzueta, Carmen, Uranjek, Jasna, Ursic, Tomaz, Vaida, Simona, Valldeperas Ferrer, Silvia, Valldeperas Hernandez, Maria Inmaculada, Valsamidis, Dimitri, Van Beek, Rienk, Van dasselaer, Nick, Van Der Beek, Tim, Van Duivenvoorde, Yoni, van Klei, Wilton A., Van Poorter, Fran, Van Zaane, Ba, Van Zundert, Tom, Van Zyl, Rebekka, Vargas Munoz, Ana Milena, Varsani, Nimu, Vasconcelos, Pedro, Vassilakis, Georgio, Vecchiatini, Tommaso, Vecera, Lubomir, Vercauteren, Marcel, Verdouw, Ba, Verheyen, Veerle, Verri, Marco, Vicari Sottosanti, Luigi Giancarlo, Vico, Manuel, Vidal Mitjans, Patricia, Vilardi, Anna, Vissicchio, Daniela, Vitale, Giovanni, Vitković, Bibiana, Vizcaychipi, Marcela Paola, Voicu, Alexandra, Voje, Minca, Volfová, Ivana, Volta, Carlo Alberto, Von Lutterotti, Theresa, von Tiesenhausen, Anna, Vrecic-Slabe, Simona, Vukcevic, Dejan, Vukovic, Rade, Vullo, P. Agostina, Wade, Andrew, Wallberg, Hanna, Wallden, Jakob, Wallner, Johann, Walther Sturesson, Louise, Watson, Davina, Weber, Stefan, Wegiel Leskiewiq, Anna, Weller, Debbie, Wensing, Carine, Werkmann, Marku, Westberg, Henrik, Wikström, Erik, Williams, Benedict, Wilson, Robin, Wirth, Steffen, Wittmann, Maria, Wood, Laura, Wright, Stella, Zachoval, Christian, Zambon, Massimo, Zampieri, Silvia, Zampone, Salvatore, Zangrillo, Alberto, Zani, Gianluca, Zavackiene, Asta, Zieglerder, Raphael, Zonneveldt, Harry, Zsisku, Lajo, Zucker, Tom-Philipp, Żukowski, Maciej, Zuleika, Mehrun, and Zupanĕiĕ, Darja

Subjects
Pulmonary and Respiratory Medicine, pulmonary complications, muscle relaxants, Post-anaesthesia complications, Neuromuscular Blockade, pulmonary complication, muscle relaxant, neuromuscular block, postoperative pulmonary complication, business.industry, Retrospective cohort study, post-operative pulmonary complications, Neuromuscular monitoring, Neuromuscular Blocking Agents, Sugammadex, NO, Anaesthesia, 03 medical and health sciences, 0302 clinical medicine, 030228 respiratory system, Anesthesia, Medicine, General anaesthesia, Neuromuscular Agents, 030212 general & internal medicine, MED/41 - ANESTESIOLOGIA, Prospective cohort study, business, medicine.drug
Abstract

Background: Results from retrospective studies suggest that use of neuromuscular blocking agents during general anaesthesia might be linked to postoperative pulmonary complications. We therefore aimed to assess whether the use of neuromuscular blocking agents is associated with postoperative pulmonary complications. Methods: We did a multicentre, prospective observational cohort study. Patients were recruited from 211 hospitals in 28 European countries. We included patients (aged ≥18 years) who received general anaesthesia for any in-hospital procedure except cardiac surgery. Patient characteristics, surgical and anaesthetic details, and chart review at discharge were prospectively collected over 2 weeks. Additionally, each patient underwent postoperative physical examination within 3 days of surgery to check for adverse pulmonary events. The study outcome was the incidence of postoperative pulmonary complications from the end of surgery up to postoperative day 28. Logistic regression analyses were adjusted for surgical factors and patients' preoperative physical status, providing adjusted odds ratios (ORadj) and adjusted absolute risk reduction (ARRadj). This study is registered with ClinicalTrials.gov, number NCT01865513. Findings: Between June 16, 2014, and April 29, 2015, data from 22 803 patients were collected. The use of neuromuscular blocking agents was associated with an increased incidence of postoperative pulmonary complications in patients who had undergone general anaesthesia (1658 [7·6%] of 21 694); ORadj 1·86, 95% CI 1·53–2·26; ARRadj −4·4%, 95% CI −5·5 to −3·2). Only 2·3% of high-risk surgical patients and those with adverse respiratory profiles were anaesthetised without neuromuscular blocking agents. The use of neuromuscular monitoring (ORadj 1·31, 95% CI 1·15–1·49; ARRadj −2·6%, 95% CI −3·9 to −1·4) and the administration of reversal agents (1·23, 1·07–1·41; −1·9%, −3·2 to −0·7) were not associated with a decreased risk of postoperative pulmonary complications. Neither the choice of sugammadex instead of neostigmine for reversal (ORadj 1·03, 95% CI 0·85–1·25; ARRadj −0·3%, 95% CI −2·4 to 1·5) nor extubation at a train-of-four ratio of 0·9 or more (1·03, 0·82–1·31; −0·4%, −3·5 to 2·2) was associated with better pulmonary outcomes. Interpretation: We showed that the use of neuromuscular blocking drugs in general anaesthesia is associated with an increased risk of postoperative pulmonary complications. Anaesthetists must balance the potential benefits of neuromuscular blockade against the increased risk of postoperative pulmonary complications. Funding: European Society of Anaesthesiology.

Published
2019
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33. Against All Odds:A Diaspora Entrepreneur Developing Russian and Central Asian Markets

Author

Maria Elo, Van Tulder, Rob, Verbeke, Alain, Carneiro, Jorge, and Gonzalez-Perez, Maria Alejandra

Subjects
Entrepreneurship, Internationalization process, 05 social sciences, Women entrepreneurs, Uzbekistan, Emerging and transition markets, Competitive advantage, Diaspora, Internationalization, Multinational corporation, 0502 economics and business, Transition economy, Emerging market multinational, Diaspora entrepreneurship, 050211 marketing, Economic geography, Business, Economic system, Emerging markets, 050203 business & management, Social capital
Abstract

Purpose To understand how diaspora entrepreneurship evolves and becomes a small-scale emerging market multinational and how this process is enabled. Methodology/approach Case study and ethnographic methods were employed. Findings Diaspora entrepreneurs can act as change agents who create and penetrate markets under difficult conditions. They are less influenced by institutional voids in home and host countries when they have strong international diaspora networks that enable a connection to resources, overcoming such voids. Diaspora entrepreneurs may be resource-embedded socially in a way that creates superior competitive advantages and reduces liabilities of foreignness and of outsidership. Research limitations/implications Diaspora entrepreneurship incorporates invisible and idiographic potential, such as social capital and knowledge networks. These are not available for other non-incumbent companies (e.g., foreign entrants) and are difficult to research due to access barriers. Practical implications Perception and active management of network-based resources is important for opportunity and business development. Management in a transition economy context requires holistic views, deep understanding, and working linkages across markets. Social implications Transgenerational entrepreneurship and ethnic traditions are important for the community. Entrepreneurship provides continuity and identity, such as using ethnic language, as well as prosperity and solidarity that are important for supporting cultural identity. Originality/value This study connects diaspora entrepreneurship in Central Asia and emerging market multinationals that are small and medium-sized enterprises. Both are underexplored domains, but may share particular institutional settings. Growth and internationalization into a multinational enterprise with an emerging market origin, especially by women entrepreneurs, are rarely studied. This case illustrates the need to capture the processual dynamics, resources, and actor networks, including sociocultural and spatiotemporal factors for better contextualization.

Published
2016
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34. Rectification of electronic heat current by a hybrid thermal diode

Author

M. J. Martínez-Pérez, Francesco Giazotto, Antonio Fornieri, MARTINEZ PEREZ, MARIA JOSE, Fornieri, Antonio, and Giazotto, Francesco

Subjects
Materials science, Biomedical Engineering, FOS: Physical sciences, Bioengineering, 02 engineering and technology, RECTIFIER, OXIDE, FLOW, 7. Clean energy, 01 natural sciences, Superconductivity (cond-mat.supr-con), Rectifier, Rectification, Mesoscale and Nanoscale Physics (cond-mat.mes-hall), 0103 physical sciences, Thermal, General Materials Science, Electrical and Electronic Engineering, Thermal diode, 010306 general physics, Electronic circuit, Superconductivity, Heat current, Condensed Matter - Mesoscale and Nanoscale Physics, business.industry, Condensed Matter - Superconductivity, Superconductivity, Mesoscopic Physics, Nanotechnology, Heat Diode, Thermal Diode, Heat Transport, 021001 nanoscience & nanotechnology, Condensed Matter Physics, Atomic and Molecular Physics, and Optics, Optoelectronics, 0210 nano-technology, business, Order of magnitude
Abstract

We report the realization of an ultra-efficient low-temperature hybrid heat current rectifier, thermal counterpart of the well-known electric diode. Our design is based on a tunnel junction between two different elements: a normal metal and a superconducting island. Electronic heat current asymmetry in the structure arises from large mismatch between the thermal properties of these two. We demonstrate experimentally temperature differences exceeding $60$ mK between the forward and reverse thermal bias configurations. Our device offers a remarkably large heat rectification ratio up to $\sim 140$ and allows its prompt implementation in true solid-state thermal nanocircuits and general-purpose electronic applications requiring energy harvesting or thermal management and isolation at the nanoscale., Comment: 8 pages, 6 color figures

Published
2015
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