1. Antibiotic Prescriptions Targeting Bacterial Respiratory Infections in Admitted Patients with COVID-19: A Prospective Observational Study
- Author
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Johan Van Laethem, Rembert Mertens, Lucie Seyler, Sven Van Laere, Silke Dirkx, Bart Ilsen, Patrick Lacor, Stephanie Wuyts, Sabine Allard, Denis Pierard, Supporting clinical sciences, Faculty of Medicine and Pharmacy, Internal Medicine, Internal Medicine Specializations, Clinical sciences, Pharmaceutical and Pharmacological Sciences, Clinical Pharmacology and Clinical Pharmacy, Biostatistics and medical informatics, Public Health Sciences, Emergency Medicine, Medical Imaging, Radiology, and Microbiology and Infection Control
- Subjects
Pulmonary and Respiratory Medicine ,Microbiology (medical) ,medicine.medical_specialty ,medicine.drug_class ,Antibiotics ,Population ,Context (language use) ,Antimicrobial stewardship ,medicine.disease_cause ,Internal medicine ,Internal Medicine ,medicine ,Infectious disease (athletes) ,Medical prescription ,education ,Original Research ,education.field_of_study ,business.industry ,COVID-19 ,Co-infection ,Infectious Diseases ,Bacterial respiratory tract infection ,Superinfection ,business ,Cohort study - Abstract
Introduction Although bacterial co- and superinfections are rarely present in patients with COVID-19, overall antibiotic prescribing in admitted patients is high. In order to counter antibiotic overprescribing, antibiotic stewardship teams need reliable data concerning antibiotic prescribing in admitted patients with COVID-19. Methods In this prospective observational cohort study, we performed a quantitative and qualitative evaluation of antibiotic prescriptions in patients admitted to the COVID-19 ward of a 721-bed Belgian university hospital between 1 May and 2 November 2020. Data on demographics, clinical and microbiological parameters and antibiotic consumption were collected. Defined daily doses (DDD) were calculated for antibiotics prescribed in the context of a (presumed) bacterial respiratory tract infection and converted into two indicators: DDD/admission and DDD/100 hospital bed days. A team of infectious disease specialists performed an appropriateness evaluation for every prescription. A driver analysis was performed to identify factors increasing the odds of an antibiotic prescription in patients with a confirmed COVID-19 diagnosis. Results Of 403 eligible participants with a suspected COVID-19 infection, 281 were included. In 13.8% of the 203 admissions with a COVID-19 confirmed diagnosis, antibiotics were initiated for a (presumed) bacterial respiratory tract co-/superinfection (0.86 DDD/admission; 8.92 DDD/100 bed days; 39.4% were scored as ‘appropriate’). Five drivers of antibiotic prescribing were identified: history of cerebrovascular disease, high neutrophil/lymphocyte ratio in male patients, age, elevated ferritin levels and the collection of respiratory samples for bacteriological analysis. Conclusion In the studied population, the antibiotic consumption for a (presumed) bacterial respiratory tract co-/superinfection was low. In particular, the small total number of DDDs in patients with confirmed COVID-19 diagnosis suggests thoughtful antibiotic use. However, antibiotic stewardship programmes remain crucial to counter unnecessary and inappropriate antibiotic use in hospitalized patients with COVID-19. Trial Registration The study is registered at ClinicalTrials.gov (NCT04544072). Supplementary Information The online version contains supplementary material available at 10.1007/s40121-021-00535-2.
- Published
- 2021
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