Search

Your search keyword '"PEAR1 gene"' showing total 2 results
Start Over Descriptor "PEAR1 gene" Topic business
2 results on '"PEAR1 gene"'

1. P5730Association of CYP2C19*2 and PEAR1 gene variant with platelet reactivity and clinical outcomes in patients undergoing stenting and treated with aspirin and clopidogrel

Author

Jun-Jie Zhang, Jingyu Chen, X Hu, Ke Xu, Chunjian Li, Yuansheng Fan, Lianghong Ying, Sen Ye, Hua-Yuan Zhu, Fuqiang Wang, Jimin Li, Lei Xu, and Li Yang

Subjects
Aspirin, medicine.medical_specialty, business.industry, CYP2C19, Clopidogrel, Gastroenterology, PEAR1 gene, Platelet reactivity, Internal medicine, medicine, In patient, Cardiology and Cardiovascular Medicine, business, medicine.drug
Published
2018
Full Text
View/download PDF

2. Identification of PEAR1 SNPs and their influences on the variation in prasugrel pharmacodynamics

Author

Yimin Cui, Qian Xiang, Nan Zhao, and Xia Zhao

Subjects
Adult, Blood Platelets, Male, Han chinese, Prasugrel, Platelet aggregation, Platelet Aggregation, Single-nucleotide polymorphism, Receptors, Cell Surface, Thiophenes, Pharmacology, Bioinformatics, Polymorphism, Single Nucleotide, Piperazines, P2Y12, Genetics, medicine, Humans, business.industry, PEAR1 gene, Adenosine Diphosphate, Pharmacogenetics, Pharmacodynamics, Molecular Medicine, Female, business, Prasugrel Hydrochloride, medicine.drug
Abstract

Aim: The present study aimed to investigate PEAR1 genetic polymorphisms and pharmacogenetic variability in the pharmacodynamics of prasugrel, a new oral antiplatelet agent, in healthy Han Chinese subjects. Patients & methods: The inhibition of adenosine diphosphate-induced platelet aggregation was measured pre- and post-administration using the VerifyNow® P2Y12 assay. The genetic sequence of PEAR1 exons and previously reported SNPs in the PEAR1 gene were investigated. Results: A total of 28 variations were identified in PEAR1. The SNPs in two regions of the PEAR1 gene, from rs3737224 to rs822442, and from rs1214331 to rs12566888, probably play important roles in prasugrel pharmacodynamics. Conclusion: Further studies with larger sample sizes are recommended to explore the clinical importance of PEAR1 SNPs in prasugrel and other antiplatelet therapies. Original submitted 18 December 2012; Revision submitted 26 April 2013

Published
2013

Catalog

Books, media, physical & digital resources
See catalog results