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Introduction The MDS-PSP criteria expand the phenotypic spectrum of PSP by adding to Richardson's syndrome (PSP-RS) other presentations such as PSP-parkinsonism (PSP–P), PSP-pure-gait-freezing (PSP-PGF), PSP-speech-language (PSP-SL), PSP-frontal (PSP–F), PSP-postural-instability (PSP-PI) and PSP-corticobasal-syndrome (PSP-CBS). Evidence about the prognostic differences between PSP phenotypes is scarce and focused on PSP-RS vs. non-PSP-RS. Using a brain-bank cohort we assessed PSP survival not only in PSP-RS vs. non-PSP-RS, but also in PSP-RS + cortical vs. subcortical phenotypes. Besides, we assessed sensitivity and specificity of the MDS-PSP criteria in of PSP and other degenerative parkinsonisms. Methods We retrospectively applied the MDS-PSP diagnostic criteria to 32 definite PSP cases and 30 cases with other degenerative parkinsonian syndromes (Parkinson's disease [PD; n = 11], multiple system atrophy [MSA; n = 11], corticobasal degeneration [CBD; n = 8]). We conducted survival statistics in neuropathologically confirmed PSP cases considering PSP-RS vs. non-PSP-RS and PSP-RS + PSP-cortical (PSP–F + PSP-SL + PSP-CBS) vs. PSP-subcortical (PSP–P + PSP-PGF) phenotypes. We also adjusted survival analyses for PSP tau scores. Results Diagnostic sensitivity was 100% and specificity ranged from 47% to 87% when excluding cases that met the “suggestive of PSP” definition early in their disease course but with other clinical features better matching with a non-PSP pathological diagnosis. Survival was significantly shorter in PSP-RS vs. non-PSP-RS cases, but it was more markedly shorter in PSP-RS + PSP-cortical vs. PSP-subcortical, independently of PSP tau scores, which were not associated with survival. Conclusions PSP-subcortical phenotypes appear to have longer survival than PSP-RS and cortical phenotypes. This might be of prognostic relevance when informing patients upon clinical diagnosis.

Improving gait is in exercise programs for older adults (OAs) but little is known about how different gait-training approaches affect spatiotemporal parameters and plantar pressure distributions in OAs. High plantar pressures are linked to tissue injury risk, ulceration, and pain in OAs, but no studies have yet compared how they affect podobarometric variables.The effect of changing plantar pressure on absolute and mean maximum pressure, the pressure-time integral, stride time, stance time, and gait speed in OAs following either a multicomponent training program (EG) or interval-walking training (WG).Comfortable gait speed, strength (seat-to-stand test), and plantar pressure (Pedar-X mobile in-shoe system), were evaluated in 23 OAs (EG: n = 12, 7 female, 71.58 ± 4.56 years; WG: n = 11, 6 female, 69.64 ± 3.56 years), by dividing the plantar area into 9 regions.After 14 weeks, the maximum pressure in medial and central metatarsus areas in the dominant leg were reduced in the EG (p = 0.01p = 0.04, respectively), but increased in the non-dominant leg lateral heel in the WG (p = 0.03). The mean maximum pressure also increased in the WG in medial heel in the dominant leg (p = 0.02) and lateral heel in the non-dominant leg (p = 0.03). The overall pressure-time integral reduced in the whole plantar area in both legs in both groups. WG reduced stride time (dominant: p = 0.01; non-dominant: p = 0.01) and stance time (dominant: p 0.005; non-dominant: p 0.005). Gait speed did not change in any group. As expected, lower limb strength improved after both exercise programs (EG: p = 0.02; WG: p = 0.01).Although these training interventions were short, they indicate the importance of exercise types. Our results suggest that OAs might benefit from periodized training, especially when multicomponent programs are introduced prior to the walking goals. Future, larger studies should explore situations in which special populations with specific foot problems might benefit from these interventions.

Purpose: To investigate the effects of two different running footwear conditions (transition to minimalist footwear and conventional running footwear) on dynamic postural stability before and after 7 weeks of gait retraining program, and to evaluate the effect of fatigue on dynamic stability. Method: This randomized controlled clinical trial was carried out by 42 recreational male runners, who were randomly divided into two groups; Conventional Footwear Group (CFG) (n = 22) and Minimalist Footwear Group (MFG) (n = 20). Dynamic Postural Stability Index (DPSI), in a fatigued and non-fatigued state, were assessed before and after a gait retraining program. The gait retraining program consisted of three guided training sessions per week for 7 weeks. Training program was mainly focused on running technique and submaximal aerobic training with step-frequency exercises. Minimalist footwear was progressively introduced in the MFG. The CFG and MFG performed the same training exercises and a full body conditioning program. Fatigue was induced using a 30-minute running test at individual 85% of the maximal aerobic speed. Results: No differences in dynamic stability variables were found between MFG and CFG in any of the study condition. MFG and CFG showed better dynamic stability after the intervention program (CFG: 13.1% of change, DPSIpre = 0.3221 ± 0.04, DPSIpost = 0.2799 ± 0.04; p < .05; MFG: 6.7% of change, DPSIpre = 0.3117 ± 0.04, DPSIpost = 0.2907 ± 0.05). Finally, dynamic stability was significatively lower in both groups after fatigue protocol (p < .05). Conclusions: Following a 7-week gait retraining program, footwear did not affect the results, being the gait retraining program more relevant on improving dynamic stability.

Se presentan las recomendaciones en las cuales la Sociedad Mexicana de Cardiología (SMC) en conjunto con la Asociación Nacional de Cardiólogos de México (ANCAM), así como diferentes asociaciones médicas mexicanas vinculadas con la cardiología, después de una revisión y análisis exhaustivo y consensuado sobre los tópicos relacionados con las enfermedades cardiovasculares en la pandemia de COVID-19, se analizan posturas científicas y se dan recomendaciones responsables sobre medidas generales a los pacientes, con cuidados personales, alimentación saludable, actividad física regular, acciones en caso de paro cardiorrespiratorio, la protección del paciente y del personal de salud así como las indicaciones precisas en el uso de la imagen cardiovascular no invasiva, la prescripción de medicamentos, cuidados en tópicos específicos como en la hipertensión arterial sistémica, insuficiencia cardiaca, arritmias y síndromes coronarios agudos, además de hacer énfasis en los procedimientos de electrofisiología, intervencionismo, cirugía cardiaca y en la rehabilitación cardiaca. El interés principal es brindar a la comunidad médica una orientación general sobre el quehacer en la práctica cotidiana y pacientes con enfermedades cardiovasculares en el escenario esta crisis epidemiológica sin precedentes de COVID-19.

Compression and temperature manipulation are discussed as strategies to improve performance markers and recovery in sports. Here, we investigate the effects of compression stockings made with fabric, either combined or not with heating and cooling substances, on variables related to running performance and recovery. Ten trained runners (mean ± standard deviation age 45 ± 9 years old, body mass 69 ± 7 kg, height 166 ± 4 cm) with no experience of using compression garments performed an intense running session of 10 km, then wore a stocking for 24 h (randomized, without compression, compression, compression with camphor, and compression with menthol), and were evaluated on the following day, after running 5 km. The different types of compression stockings used 24 h before exercise did not affect running kinematics (p &gt, 0.14), skin temperature (p &gt, 0.05), heart rate (p &gt, 0.12, mean value of maximal heart rate 156 bpm), comfort perception (p = 0.13, mean value of 7/10 points), or perception of recovery (p = 0.13, mean value of 7/10 points). In general, there were no effects of 24 h pre-exercise lower leg compression, including those treated with menthol and camphor applications on running kinematics, skin temperature, heart rate, or recovery perception in athletes undertaking consecutive running exercises.

Background and purpose: Multiple system atrophy(MSA) is a rare adult-onset synucleinopathy that can be divided in two subtypes depending on whether the prevalence of its symptoms is more parkinsonian or cerebellar (MSA-P and MSA-C, respectively). The aim of this work is to investigate the structural MRI changes able to discriminate MSA phenotypes. Methods: The sample includes 31 MSA patients (15 MSA-C and 16 MSA-P) and 39 healthy controls. Participants underwent a comprehensive motor and neuropsychological battery. MRI data were acquired with a 3T scanner (MAGNETOM Trio, Siemens, Germany). FreeSurfer was used to obtain volumetric and cortical thickness measures. A Support Vector Machine (SVM) algorithm was used to assess the classification between patients' group using cortical and subcortical structural data. Results: After correction for multiple comparisons, MSA-C patients had greater atrophy than MSA-P in the left cerebellum, whereas MSA-P showed reduced volume bilaterally in the pallidum and putamen. Using deep gray matter volume ratios and mean cortical thickness as features, the SVM algorithm provided a consistent classification between MSA-C and MSA-P patients (balanced accuracy 74.2%, specificity 75.0%, and sensitivity 73.3%). The cerebellum, putamen, thalamus, ventral diencephalon, pallidum, and caudate were the most contributing features to the classification decision (z > 3.28; p < .05 [false discovery rate]). Conclusions: MSA-C and MSA-P with similar disease severity and duration have a differential distribution of gray matter atrophy. Although cerebellar atrophy is a clear differentiator between groups, thalamic and basal ganglia structures are also relevant contributors to distinguishing MSA subtypes. Keywords: cognition; cortical thickness; machine learning; multiple system atrophy; neuroimaging.

The aim of this study is to observe the morphological and postural changes to the foot that take place during pregnancy and the puerperium. Method: In this descriptive, observational, longitudinal study, we analysed 23 pregnant women, with particular attention to morphological and postural aspects of the foot, at three time points during and after pregnancy: in weeks 9–13 of gestation, weeks 32–35 of gestation and weeks 4–6 after delivery. The parameters considered were changes in foot length, the Foot Posture Index (FPI) and the Hernández Corvo Index, which were analysed using a pedigraph and taking into account the Body Mass Index (BMI). The same procedure was conducted in each review. Results: The statistical analyses obtained for each foot did not differ significantly between the three measurement times. A pronator-type footprint was most frequently observed during the third trimester of pregnancy, it was predominantly neutral during the postpartum period. Statistically significant differences between the measurement times were obtained in the right foot for cavus vs. neutral foot type (between the first and third trimesters and also between the first trimester and the puerperium) (in both cases, p &lt, 0.0001). Conclusions: Foot length increases in the third trimester and returns to normal in the puerperium. According to FPI findings, the third trimester of pregnancy is characterised by pronation, while the posture returns to neutrality during the postpartum period. During pregnancy, the plantar arch flattens, and this persists during the puerperium. The incidence of cavus foot increases significantly in the third trimester and in the puerperium.

The unique properties that nanoparticles exhibit, due to their small size, are the principal reason for their numerous applications, but at the same time, this might be a massive menace to the environment. The number of studies that assess the possible ecotoxicity of nanomaterials has been increasing over the last decade to determine if, despite the positive aspects, they should be considered a potential health risk. To evaluate their potential toxicity, models are used in all types of organisms, from unicellular bacteria to complex animal species. In order to better understand the environmental consequences of nanotechnology, this literature review aims to describe and classify nanoparticles, evaluating their life cycle, their environmental releasing capacity and the type of impact, particularly on living beings, highlighting the need to develop more severe and detailed legislation. Due to their diversity, nanoparticles will be discussed in generic terms focusing on the impact of a great variety of them, highlighting the most interesting ones for the industry.

Objective. The temperature of the sole of the foot has been suggested as an alternative to the measurement of plantar pressure during running despite the scarce evidence about their relationship. The temperature of the footwear outsole could also be representative of plantar pressure distribution due to its less multifactorial dependence. The aim of the study was to determine if plantar pressure during a prolonged run could be related to plantar temperature, either of the sole of the foot or the footwear outsole.Approach. Thirty recreational runners (15 males and 15 females) performed a 30 min running test on a treadmill. Thermographic images of the sole of the foot and the footwear outsole were taken before and immediately after the test, and dynamic plantar pressure was measured at the end of the test. Pearson correlations and stepwise multiple linear regressions were performed.Main results.Plantar pressure percentage was related to a moderate correlation with plantar temperature percentage in forefoot and rearfoot (P

Background/Objective: Multiple system atrophy (MSA) is a highly debilitating, rare neurodegenerative disorder with two clinical motor variants (parkinsonian or MSA-P and cerebellar or MSA-C). There is a wide span of motor and non-motor symptoms (NMS) that progress over time. We studied the cohort from the Catalan Multiple System Atrophy Registry (CMSAR) to determine which symptoms are most likely to progress throughout a 2-year follow-up. Methods: We analyzed baseline, 12-month, and 24-month follow-up evaluations from the 80 cases recruited by the CMSAR. Evaluations included the UMSARS assessment, cognitive and neuropsychiatric evaluations, and a non-motor scale (NMSS-PD). Statistical analysis was done using a Generalized Estimated Equations (GEE) model. Results: Both UMSARS I and II sub-scores significantly increased at 12- and 24-month follow-ups (p

Multiple system atrophy (MSA) is an atypical parkinsonism that rapidly affects motor ability and autonomic function, leaving patients wheelchair-bound and dependent for daily activities in 3-5 years. Differential diagnosis is challenging as cases may resemble Parkinson's disease or other ataxic syndromes depending on the clinical variant (MSA-P or MSA-C), especially in early stages. There are limited symptomatic treatments and no disease-modifying therapies. Pathologically, alpha-synuclein aggregates are found in glial cytoplasmic inclusions, among other proteins, as well as in neurons. The molecular pathogenesis of the disease, however, is widely unknown. Transcriptomic studies in MSA have tried to unravel the pathological mechanisms involved in the disease. Several biological and molecular processes have been described in the literature that associate disease pathogenesis with inflammation, mitochondrial, and autophagy related dysfunctions, as well as prion disease and Alzheimer disease associated pathways. These reports have also registered several differential diagnostic biomarker candidates. However, cross-validation between studies, in general, is poor, making clinical applicability and data reliability very challenging. This review will go over the main transcriptomic studies done in MSA, reporting on the most significant transcriptive and post-transcriptive changes described, and focusing on the main consensual findings.

Infrared thermography (IRT) has been gaining in popularity in clinical and scientific research due to the increasing availability of affordable infrared cameras. This study aims to determine the similarity of measurement performance between three models of IRT camera during assessment of skin temperature before and after physical exercise. Three models of FLIR thermographic cameras (E60bx, Flir-One Pro LT, and C2) were tested. Thermal images were taken of the foot sole, anterior leg, and anterior thigh from 12 well-trained men, before and after a 30-min run on a treadmill. Image files were blinded and processed by three evaluators to extract the mean, maximum, and standard deviation of skin temperature of the region of interest. Time for data processing and rate of perceived effort was also recorded. Data processing was slower on the E60bx (CI95% E60 vs C2 [0.2, 2.6 min], p = 0.02 and ES = 0.6); vs. Flir-One [0.0, 3.4 min], p = 0.03 and ES = 0.6) and was associated with lower effort perception (E60 3.0 ± 0.1 vs. Flir-One 5.6 ± 0.2 vs C2 7.0 ± 0.2 points; p 0.001 and ES 0.8). The C2 and Flir-One cameras underestimated the temperature compared with the E60. In general, measuring mean temperature provided higher camera and examiner intra-class correlations than maximum and standard deviation, especially before exercise. Moreover, post exercise mean skin temperatures provided the most consistent values across cameras and evaluators. We recommend the use of mean temperature and caution when using more than one camera model in a study.

The individualization of a custom-made foot orthosis could provide improvements in plantar loading distribution regarding a prefabricated one. However, not all runners can afford it because of its high cost. A new type of low-cost prefabricated foot orthoses with self-customization could be the solution. The aim of the study was to evaluate if self-customized prefabricated foot orthoses (SCFO) could improve plantar pressure distribution with respect to generic prefabricated ones without customization, during the intense prolonged running. Thirty healthy recreational runners performed two tests of 30 min running on a treadmill, each one with a foot orthosis condition, on different days. Mean peak pressure, pressure-time integral, relative pressure and stance time were measured at the beginning and at the end of the tests. Plantar pressure data were analyzed in nine foot regions. Two-way repeated-measures ANOVAs were performed. SCFO reduced relative pressure in metatarsals (P 0.005) and lateral heel (P = 0.004), thanks to a greater involvement of arch area in mean peak pressure (medial: P = 0.006 and lateral: P = 0.019) and relative pressure (P 0.001). In general, prolonged run increased pressures in forefoot, in both foot orthosis, but with lower values in metatarsals with SCFO (P 0.022), which also helped reduce relative pressure in midfoot (P = 0.007) and medial heel (P = 0.035). Stance time was not modified in any case (P 0.05). In conclusion, customization and better fit of a low-cost prefabricated foot orthosis can improve plantar pressure distribution during a prolonged run, being a good prevention mechanism for plantar overloading in healthy runners.

There is a lack of evidence about the effect of different type of foot orthoses on plantar surface temperature. Moreover, that effect could be different depending on gender due to anatomical and physiological differences between men and women. The aim of the study was to analyze the effect of a prefabricated thermoformable foot orthosis on plantar surface temperature after running and taking gender differences into account. Thirty recreational runners (15 males, mean (standard deviation): 28 (7) years, 69.7 (6.5) kg, 1.74 (0.05) cm and 22.9 (1.7) kg/m2; and 15 females: 35 (7) years, 55.2 (6.9) kg, 1.63 (0.06) cm and 20.6 (1.9) kg/m2) carried out a maximum incremental test as pre-test, and two running tests on a treadmill at the laboratory wearing previously randomized different foot orthoses (thermoformable and prefabricated generic). The plantar surface temperature of the dominant foot sole in ten regions of interest was assessed before and immediately after 30-min running at 75% of VO2max. The use of thermoformable foot orthoses produced lower temperatures only in men after the run in medial heel (P = 0.033, ES = 0.7), which then disappeared in temperature variation (after – before) (P = 0.910). Regarding gender, women showed lower temperatures before the run in both orthosis conditions (P 0.8), but no differences in temperatures after the run (P = 0.910) in comparison with men. Moreover, absolute temperatures after running were always greater than before the run (P 5.0). In conclusion, the thermoformable foot orthoses do not modify plantar surface temperature after running in healthy runners of either gender, compared to prefabricated generic foot orthoses. Although women present lower baseline plantar temperatures than men, these differences disappear after exercise.

Delayed onset muscle soreness (DOMS) indicates the presence of muscle damage and impairs force production and control. Monitorization of DOMS is useful to improving recovery intervention plans. The magnitude of DOMS may relate to muscle fatigue, which can be monitored by surface electromyography (EMG). Additionally, growing interest has been expressed in determining whether the skin temperature over a muscle group during exercise to fatigue could be a non-invasive marker for DOMS. Here we determine whether skin temperature and manifestations of muscle fatigue during exercise are correlated and can predict DOMS after concentric&ndash, eccentric bicep curl exercises. We tested 10 young adults who performed concentric&ndash, eccentric bicep curl exercises to induce muscle damage in the biceps brachialis to investigate the relationship between skin temperature and fatigue during exercise and DOMS after exercise. Muscle activation and skin temperature were recorded during exercise. DOMS was evaluated 24 h after exercise. Data analysis was performed using Bayesian regression models with regularizing priors. We found significant muscle fatigue and an increase in skin temperature during exercise. DOMS was observed 24 h after exercise. The regression models showed no correlation of changes in skin temperature and muscle fatigue during exercise with DOMS 24 h after exercise. In conclusion, our preliminary results do not support a relationship between skin temperature measured during exercise and either muscle fatigue during exercise or the ability to predict DOMS 24 h after exercise.

El COVID-19 es un síndrome respiratorio agudo ocasionado por el coronavirus-2 (SARS COV2). Los diferentes métodos de imagen cardiaca han dictado recomendaciones específicas de los diferentes métodos de imagen en esta pandemia, por lo que es indispensable recalcar las recomendaciones para la realización de estos estudios.

Background Gait is negatively affected with increasing age. It is widely accepted that training produces physical-functional improvements in older adults, which can be assessed with numerous physical-functional tests. However, very few studies have been carried out using accelerometry to analyse the training effect on kinetic and kinematic variables in older adults, and there is no one that investigate the effects of two different training programs. Therefore, the aim of this study is to analyse the effects of an interval-walking program and a multicomponent program on the acceleration impacts, shock attenuation, step-length, stride frequency, and gait speed in older adults. Methods 23 participants were divided into multicomponent training group [n = 12, 7 female, 71.58 (4.56) years] and interval-walking group [n = 11, 6 female, 69.64 (3.56) years]. We evaluated the participants using three triaxial accelerometers, placing one on the distal end of each tibia and one on the forehead. Findings After 14 weeks' of training, the maximum acceleration values both for the head accelerometer and for the non-dominant tibia, as well as the attenuation in the same leg, increased in the multicomponent training group. The maximum acceleration values for the head and the stride frequency also increased in the interval-walking group. Lower limb strength improved in both groups. Interpretation Given the benefits we found for each of these programs, we encourage their consideration when planning older adults training programs and suggest that multicomponent programs should be introduced prior to the start of walking-based programs.

The study aimed at assessing the acute physiological effects of running a 65-km vs a 107- km mountain ultramarathon. Nineteen athletes (15 males and 4 females) from the shorter race and forty three athletes (26 males and 17 females) from the longer race were enrolled. Body weight, respiratory and lower limb strength were assessed before and after the race. Blood samples were obtained before, after and 24-h post-race. Body weight loss did not differ between races. A decrease in squat jump height (p

The objective of the present study was to investigate differences in oral activity when biscuits of the same type but with subtle composition differences are consumed and how performing a Temporal Dominance of Sensations (TDS) task modifies the way one eats. In addition, comparisons were made between performing a texture TDS (T-TDS) and a flavour TDS (F-TDS). Oral activity while eating biscuits with and without conducting a TDS task was recorded using a 3.dimensional motion capture system to monitor the evolution of jaw movements. The results showed that oral activity evolved over the consumption time, differed depending on the texture of the sample and was affected to a small but significant extent when a TDS task was performed simultaneously (the differences averaged, The authors are grateful to the Spanish Ministry of the Economy and Competitiveness (AGL-2016-75403-R, Spain) and to the Regional Government of Valencia (Project Prometeo 2017/189, Spain) for financial support.

The aim of this study was to assess the influence of different bike positions on the perception of fatigue, pain and comfort. Twenty cyclists underwent three tests that involved cycling for 45 min at their individual 50% peak aerobic power output while adopting different positions on the bike. Participants performed the cycling tests adopting three positions defined by two parameters (knee flexion angle [20°, 30°, 40°] and trunk flexion angle [35°, 45°, 55°]) in random order. Angles were measured using a 2D motion analysis system during cycling and applying Fonda's correction factor. Perceptions of comfort, fatigue and pain were reported before the end of each test. The combination of 40° knee flexion and 35° trunk flexion was perceived as the most uncomfortable position. Moreover, greater knee flexion had a negative effect on trunk comfort, accompanied by greater levels of fatigue and pain perception in the anterior part of the thigh and knee. In conclusion, cyclists perceived the most comfortable position to be when the saddle height was within the recommended knee angle (30° calculated from the offset position or 40 ± 4.0° of absolute value). Upright trunk was found to be the most comfortable position for recreational cyclists, where aerodynamics is not so important. Cyclists' bike perceptions should be taken into account when it comes to choosing the most beneficial position, since this can play a role in injury prevention and enhance cycling performance.

Runners tend to shift from a rearfoot to a forefoot strike pattern when running barefoot. However, it is unclear how the first attempts at running barefoot affect habitually rearfoot shod runners. Due to the inconsistency of their recently adopted barefoot technique, a number of new barefoot-related running injuries are emerging among novice barefoot runners. The aim of this study was therefore to analyse the influence of three running conditions (natural barefoot [BF], barefoot with a forced rearfoot strike [BRS], and shod [SH]) on muscle activity and impact accelerations in habitually rearfoot shod runners. Twenty-two participants ran at 60% of their maximal aerobic speed while foot strike, tibial and head impact accelerations, and tibialis anterior (TA), peroneus longus (PL), gastrocnemius medialis (GM) and gastrocnemius lateralis (GL) muscle activity were registered. Only 68% of the runners adopted a non-rearfoot strike pattern during BF. Running BF led to a reduction of TA activity as well as to an increase of GL and GM activity compared to BRS and SH. Furthermore, BRS increased tibial peak acceleration, tibial magnitude and tibial acceleration rate compared to SH and BF. In conclusion, 32% of our runners showed a rearfoot strike pattern at the first attempts at running barefoot, which corresponds to a running style (BRS) that led to increased muscle activation and impact accelerations and thereby to a potentially higher risk of injury compared to running shod.

The aim of the study was to evaluate an automatic thermographic software package (ThermoHuman®) for assessing skin temperature on the soles of the feet before and after running and to compare it with two manual definitions of the regions of interest (ROIs). 120 thermal images of the soles of the feet of 30 participants, at two measurement points (before and after running 30 min) and on two measurement days were analyzed. Three different models of thermographic image analyses were used to obtain the mean temperature of 9 ROIs: A) ThermoHuman (automatic definition of ROIs using ThermoHuman® software), B) Manual (manual delimitation of ROIs by proportion criteria), and C) Manual-TH (manual delimitation of ROIs in an attempt to replicate the regions analyzed by ThermoHuman). ThermoHuman resulted in an 86% reduction in time involved compared to manual delimitation. Fourteen of the 120 images (12%) presented some error in one or more of the ROI delimitations. Although the three procedures presented significant differences between them (53% in the comparison between ThermoHuman and Manual, 47% between ThermoHuman and Manual-TH, and 28% between Manual and Manual-TH), all differences had a small effect size (ES 0.2-0.4) or lower (ES 0.2). Bland-Altman plots showed similar 95% limits of agreement between the three procedures before and after running. Intraclass correlation coefficient analysis of the three procedures presented excellent reliability (ICC0.8). In conclusion, ThermoHuman® software was observed to be time-saving for image analysis with excellent reliability. Although results suggest that ThermoHuman® and manual methods are both valid in themselves, combining them is not recommended due to the differences observed between them.

The aim of the study was to evaluate skin temperature of the soles of the feet before and after a provoked asymmetrical running. Seventeen recreational male runners performed two 15 min running tests in the same session. In the first test, participants performed running without modifying their running technique (control condition). In the second running test, they repeated the same protocol using an ankle weight of 1.5 kg in the non-dominant ankle (asymmetrical condition). Rate of perceive exertion, heart rate and spatio-temporal parameters were measured during the running tests. Skin temperature was measured with an infrared camera before and after each condition. Generally, comparing both lower limbs, non-preferred limb (with the ankle weight) had lower contact time (p 0.001 and ES 0.8), higher stride length (p 0.05 and ES 0.3) and higher stride frequency in asymmetrical condition (p 0.01 and ES 0.4). However, no differences were observed on skin temperature between both feet in the two conditions in any of the regions of interest assessed (p 0.05). Although the asymmetry generation model used provoked technical asymmetries in spatio-temporal parameters during running, no thermal asymmetries were observed between preferred and non-preferred sole of the foot. These results suggested the lower importance of mechanical than physiological mechanisms on skin temperature during running.

Recent studies combining diffusion tensor-derived metrics and machine learning have shown promising results in the discrimination of multiple system atrophy (MSA) and Parkinson’s disease (PD) patients. This approach has not been tested using more complex methodologies such as probabilistic tractography. The aim of this work is assessing whether the strength of structural connectivity between subcortical structures, measured as the number of streamlines (NOS) derived from tractography, can be used to classify MSA and PD patients at the single-patient level. The classification performance of subcortical FA and MD was also evaluated to compare the discriminant ability between diffusion tensor-derived metrics and NOS. Using diffusion-weighted images acquired in a 3 T MRI scanner and probabilistic tractography, we reconstructed the white matter tracts between 18 subcortical structures from a sample of 54 healthy controls, 31 MSA patients and 65 PD patients. NOS between subcortical structures were compared between groups and entered as features into a machine learning algorithm. Reduced NOS in MSA compared with controls and PD were found in connections between the putamen, pallidum, ventral diencephalon, thalamus, and cerebellum, in both right and left hemispheres. The classification procedure achieved an overall accuracy of 78%, with 71% of the MSA subjects and 86% of the PD patients correctly classified. NOS features outperformed the discrimination performance obtained with FA and MD. Our findings suggest that structural connectivity derived from tractography has the potential to correctly distinguish between MSA and PD patients. Furthermore, NOS measures obtained from tractography might be more useful than diffusion tensor-derived metrics for the detection of MSA.

Background Recent studies using resting-state functional connectivity and machine-learning to distinguish patients with neurodegenerative diseases from other groups of subjects show promising results. This approach has not been tested to discriminate between Parkinson's disease (PD) and multiple system atrophy (MSA) patients. Objectives Our first aim is to characterize possible abnormalities in resting-state functional connectivity between the cerebellum and a set of intrinsic-connectivity brain networks and between the cerebellum and different regions of the striatum in PD and MSA. The second objective of this study is to assess the potential of cerebellar connectivity measures to distinguish between PD and MSA patients at the single-patient level. Methods Fifty-nine healthy controls, 62 PD patients, and 30 MSA patients underwent resting-state functional MRI with a 3T scanner. Independent component analysis and dual regression were used to define seven resting-state networks of interest. To assess striatal connectivity, a seed-to-voxel approach was used after dividing the striatum into six regions bilaterally. Measures of cerebellar-brain network and cerebellar-striatal connectivity were then used as features in a support vector machine to discriminate between PD and MSA patients. Results MSA patients displayed reduced cerebellar connectivity with different brain networks and with the striatum compared with PD patients and with controls. The classification procedure achieved an overall accuracy of 77.17% with 83.33% of the MSA subjects and 74.19% of the PD patients correctly classified. Conclusion Our findings suggest that measures of cerebellar functional connectivity have the potential to distinguish between PD and MSA patients., Highlights • Reduced cerebellar functional connectivity in MSA compared with healthy controls. • Reduced cerebellar-striatal functional connectivity in MSA compared with PD. • Reduced connectivity between cerebellum and brain networks in MSA compared with PD. • Cerebellar connectivity might help discriminate between MSA and PD patients.

Foot orthosis is a popular strategy for runners aiming to reduce the injury risk and improve performance in running. Companies of foot orthosis claim for a high number of benefits, however, the literature is controversy in many aspects and there are not systematic results because of the use of them. The aim of this chapter is, firstly, to introduce the reader about the concept of foot orthosis and its different definitions and types. Secondly, to show the most important scientific literature about its biomechanical and physiological effects during running. These biomechanical and physiological effects were divided into the following sections in order to be clear for the reader: kinematics, impact transmission, plantar pressure, neuromuscular activation, comfort perception, and thermal assessment. Finally, some indications of future research were provided.

In this chapter we summarize the main scientific information regarding the applications of compression garments in sports. This chapter covers the discussion from the clinical compression’s application in patients to how its use has been extended to sport. In addition, the composition and different kinds of textiles are considered regarding the level of compression and methodologies/standards for its classification. The chapter is organized in sections considering the effects of compression garments on physiological, psychological, strength, power, endurance, and muscle activation parameters, and ends with indications of future research directions and methodological aspects regarding compression in sport.

Introduction: Neuroinflammation is a potential player in neurodegenerative conditions, particularly the aggressive ones, such as multiple system atrophy (MSA). Previous reports on cytokine levels in MSA using serum or cerebrospinal fluid (CSF) have been inconsistent, including small samples and a limited number of cytokines, often without comparison to Parkinson's disease (PD), a main MSA differential diagnosis. Methods: Cross-sectional study of CSF levels of 38 cytokines using a multiplex assay in 73 participants: 39 MSA patients (19 with parkinsonian type [MSAp], 20 with cerebellar type [MSAc]; 31 probable, 8 possible), 19 PD patients and 15 neurologically unimpaired controls. None of the participants was under non-steroidal anti-inflammatory drugs at the time of the lumbar puncture. Results: There were not significant differences in sex and age among participants. In global non-parametric comparisons FDR-corrected for multiple comparisons, CSF levels of 5 cytokines (FGF-2, IL-10, MCP-3, IL-12p40, MDC) differed among the three groups. In pair-wise FDR-corrected non-parametric comparisons 12 cytokines (FGF-2, eotaxin, fractalkine, IFN-α2, IL-10, MCP-3, IL-12p40, MDC, IL-17, IL-7, MIP-1β, TNF-α) were significantly higher in MSA vs. non-MSA cases (PD + controls pooled together). Of these, MCP-3 and MDC were the most significant ones, also differed in MSA vs. PD, and were significant MSA-predictors in binary logistic regression models and ROC curves adjusted for age. CSF levels of fractalkine and MIP-1α showed a strong and significant positive correlation with UMSARS-2 scores. Conclusion: Increased CSF levels of cytokines such as MCP-3, MDC, fractalkine and MIP-1α deserve consideration as potential diagnostic or severity biomarkers of MSA. info:eu-repo/semantics/publishedVersion

Foot orthoses are one of the most used strategies by healthy runners in injury prevention and performance improvement. However, their effect on running kinematics throughout an intense prolonged run in this population is unknown. Moreover, there is some controversy regarding the use of custom-made versus prefabricated foot orthoses. This study analysed the effect of different foot orthoses (custom-made, prefabricated and a control condition) on spatio-temporal and angular (knee flexion and foot eversion) kinematic parameters and their behaviour during an intense prolonged run. Twenty-four recreational runners performed three similar tests that consisted of running 20 min on a treadmill at 80% of their maximal aerobic speed, each one with a different foot orthosis condition. Contact and flight time, and stride length and stride rate were measured every 5 min by an optical measurement photoelectric cell system. Knee flexion and foot eversion kinematic parameters were measured by two high-speed cameras. No significant differences were found between the different foot orthoses in any of the time points studied and between the interaction of foot orthosis and behaviour over time, in any of the variables studied (P > 0.05). The use of custom-made and prefabricated foot orthoses during an intense prolonged run does not produce changes in spatio-temporal and kinematic parameters in healthy runners. These results suggest that a healthy runner maintains its ideal movement pattern throughout a 20 minute prolonged run, regardless the type of foot orthosis used.

Excessive and prolonged exposure to impact acceleration during running is associated with increased injury rate. Acute use of compressive garments has been speculated to improve attenuation. However, it is unknown how longer interventions of compressive garments influence attenuation in running. 40 runners trained with compressive and placebo stockings for 3 weeks. Perception of comfort, stride parameters (rate, length) and impact acceleration (head and tibial peak acceleration, magnitude, acceleration rate and attenuation) were measured every 5 min during a fatigue run (30 min at 80% of the individual's maximal aerobic speed). Compressive stockings reduced tibial peak acceleration and magnitude compared to placebo stockings at every minute (p0.05) except for the initial measurement (p0.05). Moreover, compressive stockings led to a lower rate of increase in tibial peak acceleration (14%, p0.005) and magnitude (16%, p0.001) as a result of the development of fatigue compared to placebo stockings (24% and 26% increase, p=0.014 and p=0.003, respectively). Similar perception of comfort was reported for both garments. Training with compressive stockings for 3 weeks reduced impact acceleration and the rate of increase in acceleration compared to placebo stockings. These findings suggest that compressive stockings may play a protective role by reducing impact accelerations during running.

The use of graduated compression stockings (GCS) in sport has been increasing in the last years due to their potential positive effects for athletes. However, there is little evidence to support whether these types of garments actually improve cardiorespiratory performance. The aim of this study was to examine the cardiorespiratory responses of GCS during running after three weeks of regular use. Twenty recreational runners performed three tests on different days: test 1) ¿ a 5-min maximal effort run in order to determine the participants¿ maximal aerobic speed; and tests 2) and 3) ¿ a fatigue running test of 30 minutes at 80% of their maximal aerobic speed with either GCS or PLACEBO stockings at random. Cardiorespiratory parameters (minute ventilation, heart rate, relative oxygen consumption, relative carbon dioxide production, ventilatory equivalents for oxygen and carbon dioxide, and oxygen pulse) were measured. Before each test in the laboratory, the participants trained with the randomly assigned stockings (GCS or PLACEBO) for three weeks. No significant differences between GCS and PLACEBO were found in any of the cardiorespiratory parameters. In conclusion, the present study provides evidence that running with GCS for three weeks does not influence cardiorespiratory parameters in recreational runners.

The deceleration of the body at each foot strike during running generates a shock wave that is transmitted from the foot to the head. An elevated magnitude of this wave, measured as impact accelerations, has been associated with increased risk of injury in athletes. Even though a number of training strategies such as realtimefeedback have aimed to modify the athlete’s running technique and reduce their injury risk, the instructions given to these runners are vague and difficult to replicate by other runners. Therefore, the aim of this study was to analyse if an 8-week running program specifically focused on improving running technique influenced stride and impact accelerations during running. Twenty-nine recreational runners underwent a supervised program consisting of 3 sessions of 30 minutes per week during 8 weeks. In addition, before and after the running program, participants carried out a 20-min running test at 80% of their individual HRmax where stride and tibial and head impact acceleration parameters were collected. Although the program did not influence stride rate and stride length, a reduction of the tibial and head acceleration magnitudes (by 8% (p=0.023) and 42% (p

The main instruments to assess foot eversion have some limitations (especially for field applications), and therefore it is necessary to explore new methods. The objective was to determine the relationship between foot eversion and skin temperature asymmetry of the foot sole (difference between medial and lateral side), using infrared thermography. Twenty-two runners performed a running test lasting 30 min. Skin temperature of the feet soles was measured by infrared thermography before and after running. Foot eversion during running was measured by kinematic analysis. Immediately after running, weak negative correlations were observed between thermal symmetry of the rearfoot and eversion at contact time, and between thermal symmetry of the entire plantar surface of the foot and maximum eversion during stance phase (r=-0.3 and p=0.04 in both cases). Regarding temperature variations, weak correlations were also observed (r=0.4 and p

BACKGROUND: Exercise is important as adjuvant in the chronic low back pain (CLBP) treatment. Functional training could involve benefits for low back pain (LBP) patients. OBJECTIVE: To evaluate the effects of a 12-week period of functional resistance training on health-related quality of life (HRQOL), disability, body pain, and physical fitness in CLBP females. METHODS: Nineteen females CLBP were recruited according to Paris Task Force on Back Pain criteria. Participants were randomly assigned to an exercise group (EG); and a control group (CG). Subjects were tested at baseline and at week 12 after 24 sessions, 2 days per week. Body pain was assessed using visual analog scale (VAS), disability with Oswestry Disability Index (ODI) and HRQOL with Short Form 36 questionnaire. Physical fitness was measured using: flamingo test, back endurance test, side bridge test, abdominal curl-up tests, and 60-s squat test. RESULTS: EG showed significant improvements in physical function (10%; p< 0.05), body pain (42%; p< 0.05), vitality (31%; p< 0.05), physical component scale (15%; p< 0.05), VAS (62.5%; p< 0.01), ODI (61.3%; p< 0.05), balance (58%; p< 0.05), curl-up (83%; p< 0.01), squat (22%; p< 0.01), static back (67%; p< 0.01), and side bridge (56%; p< 0.01). CONCLUSION: Periodized functional resistance training decreased pain and disability and improved HRQOL, balance and physical fitness in females with CLBP, and can thus be used safely in this population. This study was supported by grant: DEP2011-30009-C02-01 from the Spanish Ministry of Economy and Competitiveness.

Purpose: Graduated compressive stockings (GCS) have been suggested to influence performance by reducing muscle oscillations and improving muscle function and efficiency. However, no study to date has analyzed the influence of GCS on muscle activity during running. The objective of the study was to analyze the influence of GCS on the perception of comfort and muscle activation of the main muscles of the lower leg during running. Method: Thirty-six participants ran on a treadmill with (GCS) or without (control) GCS. The running tests consisted of a 10-min warm-up followed by a 20-min intense run at 75% of the athlete’s maximal aerobic speed. Surface electromyography of the tibialis anterior, peroneus longus, gastrocnemius lateralis (GL), and gastrocnemius medialis (GM) were recorded every 5 min during the run and analyzed using a non-linearly scaled wavelet analysis. Perception of comfort of the GCS was measured before and after the run. Results: The GCS were reported as comfortable garments and reduced GL activity at Minute 0 (p < .05, = .245) and Minute 5 (p < .05, = .326) and GM activity at Minute 0 (p < .05, = .233) compared with running without garments, but their effect was temporary and disappeared after 5 min of running. Conclusion: Even though GCS reduced gastrocnemius muscle activity during the initial minutes of running, it is hypothesized that the GCS could have lost their initial levels of compression after some minutes of exercise, thereby reducing their influence on muscle activation. However, this hypothesis needs to be further investigated. This work was supported by the Spanish government (Ministerio de Educacion, Cultura y Deporte [grant FPU] and Subdirección General de Proyectos de Investigación: Convocatoria Proyectos I+D Excelencia, Subprograma de Generación de Conocimiento, 2013 [DEP2013-48420-P]).

Summary Objectives The aim of this study was to analyse the plantar pressure pattern, contact time, stride rate and impact acceleration in the shank during walking with and without Kinesio Tape (KT®) placed on two muscle groups: peroneus and triceps surae. Methods Among the subjects, 29 (12 men, 17 women) participated in the study. KT® was placed on the triceps surae and peroneus and participants walked at two different speeds (V1: 0.73 m/s; V2: 1.30 m/s) with and without KT®. The pedobarographic system Biofoot IBV® 6.0 was used to analyse plantar pressure (mean peak pressure [kPa]) in 5 foot areas and the kinematic variables of the study (contact time [s]; stride rate [steps/second]). One uni-axial accelerometer (Sportmetrics®) was placed on the shank for the impact loading analysis. Results No significant difference was observed on plantar pressure (P > 0.05), and kinematics variables (P > 0.05) with and without KT®. However, results revealed a relationship of dependence between speed and plantar pressure and kinematics parameters, especially under the rearfoot and the medial part of the foot (P Conclusion The results suggest that application of KT® on peroneus and triceps surae does not have a direct effect on impact accelerations and plantar pressure pattern of healthy individuals during walking.

OBJECTIVE Foot orthoses are increasingly used by runners despite the controversy about whether their use can reduce the risk of overuse injuries. Some authors have found modifications in plantar pressures with the use of foot orthoses, which could produce changes in the surface skin temperature of the foot soles. The aim of this study was to analyse the effects of custom-made and prefabricated foot orthoses on the skin temperature of different regions of both foot soles after running. APPROACH Twenty-four participants carried out a maximal aerobic speed test as a pre-test, and three running tests at the laboratory wearing different foot orthoses conditions (control, prefabricated and custom-made) previously randomized. Skin temperature of four regions of interest of the foot soles was assessed before, immediately after and ten minutes after running. MAIN RESULTS The use of prefabricated and custom-made foot orthoses did not produce changes on skin temperature of the foot soles neither in absolute temperatures (p > 0.05), nor in temperature variations: between immediately after and before running (p > 0.05), and between ten minutes after and immediately after running (p > 0.05). Otherwise, higher values were found with no insoles than with prefabricated foot orthoses, 10 min after running in relation to before running, in forefoot [mean (standard deviation): 5.6 (2.4) versus 3.7 (2.7) °C; p = 0.02; effect size (ESd) = 0.72], midfoot [3.7 (1.5) versus 2.7 (1.5) °C; p = 0.03; ESd = 0.65] and rearfoot [4.18 (2.05) versus 2.9 (1.82) °C; p = 0.02; ESd = 0.64)]. SIGNIFICANCE In conclusion, the use of foot orthoses, in general, does not affect the surface skin temperature of the foot soles after an intense run.

The differences produced when running on a treadmill vs overground may call into question the use and validity of the treadmill as a piece of equipment commonly used in research, training, and rehabilitation. The aim of the present study was to analyze under pre/post fatigue conditions the effect of treadmill vs overground on plantar pressures. Twenty-seven recreational runners (17 men and 10 women) ran on a treadmill and overground at two speeds: S 1 = 3.33 m/s and S 2 = 4.00 m/s, before and after a fatigue protocol consisting of a 30-min run at 85% of their individual maximal aerobic speed (MAS). Contact time (CT in seconds), peak pressure (PP in kPa), and relative load (RL in %) were analyzed under nine foot zones of the left foot using an in-shoe plantar pressure device. A two-way repeated measures ANOVA showed that running on a treadmill increases CT (7.70% S 1 and 9.91% S 2 ), modifies the pressure distribution and reduces PP (25.98% S 1 and 31.76% S 2 ), especially under the heel, medial metatarsals, and hallux, compared to running overground. Moreover, on both surfaces, fatigue ( S 2 ) led to a reduced stride frequency (2.78%) and reduced PP on the lateral heel and hallux (15.96% and 16.35%, respectively), and ( S 1 ) increased relative load on the medial arch (9.53%). There was no significant interaction between the two factors analyzed (surface and fatigue). Therefore, the aforementioned surface effect, which occurs independently of the fatigue state, should be taken into account when interpreting the results of studies that use the treadmill in their experimental protocols, and when prescribing physical exercise on a treadmill.

[EN] Each time the foot contacts the ground during running there is a rapid deceleration that results in a shock wave that is transmitted from the foot to the head. The fatigue of the musculoskeletal system during running may decrease the ability of the body to absorb those shock waves and increase the risk of injury. Insoles are commonly prescribed to prevent injuries, and both custom-made and prefabricated insoles have been observed to reduce shock accelerations during running. However, no study to date has included a direct comparison of their behaviour measured over the same group of athletes, and therefore great controversy still exists regarding their effectiveness in reducing impact loading during running. The aim of the study was to analyse the acute differences in stride and shock parameters while running on a treadmill with custom-made and prefabricated insoles. Stride parameters (stride length, stride rate) and shock acceleration parameters (head and tibial peak acceleration, shock magnitude, acceleration rate, and shock attenuation) were measured using two triaxial accelerometers in 38 runners at 3.33 m/s before and after a 15-min intense run while using the sock liner of the shoe (control condition), prefabricated insoles and custom-made insoles. No differences in shock accelerations were found between the custom-made and the control insoles. The prefabricated insoles increased the head acceleration rate (post-fatigue, p = 0.029) compared to the control condition. The custom-made reduced tibial (pre-fatigue, p = 0.041) and head acceleration rates (pre-fatigue and post-fatigue, p = 0.01 and p = 0.046) compared to the prefabricated insoles. Neither the stride nor the acceleration parameters were modified as a result of the intense run. In the present study, the acute use of insoles (custom-made, prefabricated) did not reduce shock accelerations compared to the control insoles. Therefore, their effectiveness at protecting against injuries associated with elevated accelerations is not supported and remains unclear., This work was supported by the Spanish Government (Ministerio de Educacion, Cultura y Deporte, Grant FPU; and Ministerio de Economia y Competitividad, Subdireccion General de Proyectos de Investigacion, Convocatoria Proyectos I+D Excelencia, Subprograma de Generacion de Conocimiento, 2013, Grant DEP2013-48420-P).

Within the various chapters of this book, the methodology and different applications of infrared thermography in sport science will be discussed. But what are the origins of infrared thermography? What has its development been like in sport science? The present introductory chapter of the book aims to show the historical developments of infrared thermography and, fundamentally, its application in sport science.

Thermographic studies of the foot can be very useful in 3 different ways: in preventing injury, in analyzing sporting technique and in assessing the effects of footwear and clothing. The aim of this chapter is to discuss several methodological points concerning the thermal analysis of the foot using infrared thermography, as well as to discuss how it can be applied to the science of sports, both in areas already researched and those as yet uninvestigated.

[EN] Filtering the signal recorded by an accelerometer is essential to remove noise recorded by the sensor, but in order to calculate gait parameters properly, the choice of a suitable cutoff frequency of the filter is critical. This paper evaluates the influence of the filter cutoff frequency in the calculation of the parameters: vertical peak tibial acceleration and acceleration rate. The accelerometer signal filtering with low-pass filter with cutoff frequency below 50 Hz gives good results in the calculation of peak tibial acceleration but produces estimations of the acceleration rate below its real value, This work has been sponsored by the Generalitat Valenciana: application 09.02.03.542.50.7 budget line T4015 grant from the “Conselleria de Educación, Cultura y Deporte”, aid for conducting R & D for emerging research groups corresponding to the call set out in Annex IX, the Order 64/2014, of July 31, the “Conselleria de Educación, Cultura y Deporte” (DOCV no. 7.332, of August 5, 2014). Record GV /2015/067.