1. Burkitt lymphoma and Ewing sarcoma in a child with Williams syndrome
- Author
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Nelli Vanhapiha, Kim Vettenranta, Olli Lohi, and Sakari Knuutila
- Subjects
Chromosome 7 (human) ,business.industry ,Chromosome ,Chromosomal translocation ,Hematology ,medicine.disease ,3. Good health ,Lymphoma ,Blood cancer ,Neurodevelopmental disorder ,Oncology ,Pediatrics, Perinatology and Child Health ,Immunology ,medicine ,Cancer research ,Sarcoma ,Williams syndrome ,business - Abstract
Williams syndrome (WS) is a relatively rare multisystem neurodevelopmental disorder caused by a hemizygous deletion of contiguous genes on chromosome 7q11.23. Although WS does not predispose carriers to cancers, alterations of chromosome 7 are common in several human neoplasms. We report here a patient with WS and two different cancers, Burkitt lymphoma and Ewing sarcoma. Array-CGH analysis of the patient blood revealed a constitutive 1.4 million base pair deletion at 7q11.23, compatible with WS diagnosis. Pediatr Blood Cancer 2014; 61:1877–1879. © 2014 Wiley Periodicals, Inc.
- Published
- 2014
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