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Rosai‐Dorfman disease (RDD), as a lymphoproliferative disorder with unknown etiology, is commonly identified with systemic clinical manifestations in various organs. In this case study, RDD occurrence was reported with an exceedingly liver mass.

This care report presents a 51-year-old woman patient with a cyst-like mass in the liver. The proliferated histiocytes, with the eosinophilic nucleolus, occasionally showing lymphophagocytosis (emperipolesis) positively for CD68 protein S-100 were reported in the pathological study, and the plasma cells were positive for CD138, consistent with Rosai-Dorfman disease.

Although both esophageal and gastric cancers are highly prevalent, the prevalence of both esophageal and gastric cancers simultaneously is very rare overall. Herein, we present a case of simultaneous occurrence of two cancers including esophageal squamous cell carcinoma and gastric adenocarcinoma.