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1. Delay of endoscopic submucosal dissection-induced gastric ulcer healing by methotrexate

Author

Jutaro Miyamoto, Jun Nishikawa, Takao Nakashima, Isao Sakaida, Ryo Kawasato, Seiji Tsuchida, Shu Kiyotoki, Koji Tanigawa, Mitsuru Yasunaga, Takakazu Furutani, and Hirokazu Ozawa

Subjects
musculoskeletal diseases, medicine.medical_specialty, Abdominal pain, Endoscopic Mucosal Resection, Vonoprazan, 03 medical and health sciences, 0302 clinical medicine, immune system diseases, Stomach Neoplasms, Internal medicine, Medicine, Humans, heterocyclic compounds, Stomach Ulcer, skin and connective tissue diseases, Ulcer, business.industry, Gastroenterology, Proton Pump Inhibitors, General Medicine, Hepatology, medicine.disease, digestive system diseases, Colorectal surgery, Discontinuation, Surgery, Methotrexate, Gastric Mucosa, 030220 oncology & carcinogenesis, Rheumatoid arthritis, 030211 gastroenterology & hepatology, medicine.symptom, business, medicine.drug, Abdominal surgery
Abstract

We report a case of methotrexate (MTX) delaying the healing of an endoscopic submucosal dissection (ESD)-induced gastric ulcer. The patient, who had been taking MTX for rheumatoid arthritis, underwent ESD for early gastric carcinoma. Despite taking vonoprazan after ESD, abdominal pain and anorexia continued, and the gastric ulcer did not heal after the ESD. After discontinuing MTX, the patient's symptoms improved and the ulcer healed. Patients taking MTX require careful follow-up after ESD, considering that ulcers can be difficult to heal. Discontinuation of MTX should be considered if delayed healing of an ulcer is observed.

Published
2021

2. Laparoscopic distal pancreatectomy using 3D-model navigation system

Author

Mitsuru Yasunaga, Koken Okuda, Hisamune Sakai, K. Ryuuichi Kawahara, Hirono Ishikawa, Toru Hisaka, and Yoshito Akagi

Subjects
medicine.medical_specialty, Hepatology, business.industry, Gastroenterology, medicine, Navigation system, 3d model, Distal pancreatectomy, business, Surgery
Published
2019

3. [Untitled]

Author

Mitsuru Yasunaga, Isao Sakaida, Kazuyuki Takenaka, and Kiwamu Okita

Subjects
Pathology, medicine.medical_specialty, Necrosis, biology, Physiology, business.industry, Gastroenterology, Fibrin, Microcirculation, Perisinusoidal space, Massive Hepatic Necrosis, Edema, biology.protein, medicine, Platelet, Tumor necrosis factor alpha, medicine.symptom, business
Abstract

Recent studies have suggested an association between tumor necrosis factor-alpha (TNF-alpha) and the development and progression of acute liver failure. To investigate the role of TNF-alpha in the mechanism of massive hepatic necrosis, we studied a mouse model of TNF-alpha and D-galactosamine (GalN) -induced hepatic necrosis by ultrastructural analysis. Administration of GalN caused edema of hepatocellular microvilli and widening of sinusoidal endothelial fenestrae (SEF); administration of TNF-alpha caused only a widening of the SEF. Massive hepatic necrosis with hemorrhage was seen 6 hr after concomitant administration of TNF-alpha and GalN. In the ultrastructural analysis, edema of the hepatocellular microvilli, widening of the SEF, and transmigration of red blood cells (RBC) and platelets to the space of Disse without exfoliation and necrosis of the sinusoidal endothelial cells were observed. Fibrin deposits were seen in areas adjacent to injured hepatocytes. The diameter of the SEF was significantly greater than in the nontreated group and the groups treated with TNF-alpha or GalN alone. These results suggest that as a consequence of the increase in diameter of the SEF, transmigration of RBCs and platelets to the space of Disse may have resulted in massive hepatic necrosis due to occlusion of the microcirculation.

Published
1998

5. Percutaneous hot water injection therapy (PHoT) for treatment of hepatocellular carcinoma: a comparision with percutaneous ethanol injection therapy (PEIT)

Author

Mitsuru Yasunaga, Kazuhiko Irie, Kiwamu Okita, Aogu Yamashita, Yuko Matsuzaki, Fumie Kurokawa, Takahiro Yamasaki, and Shuji Terai

Subjects
medicine.medical_specialty, Percutaneous, Hepatology, business.industry, medicine.medical_treatment, Residual cancer, Urology, Phot, Marked effect, medicine.disease, Surgery, Hepatocellular carcinoma, medicine, In patient, Percutaneous ethanol injection, Adverse effect, business
Abstract

We investigated the safety and efficacy of percutaneous hot water injection therapy (PHoT) in six patients with hepatocellular carcinoma (HCC). PHoT produced the marked effect in five (62.5%) of eight lesions. No serious adverse effects have been encountered. We also compared the usefulness of percutaneous ethanol injection therapy (PEIT) (22 patients, 32 lesions) and PHoT (five patients, seven lesions) in patients with HCC with diameter of 3 cm or less. Patients in the PHoT group received significantly fewer treatments than in the PEIT group (P < 0.01), because the volume injected per treatment was greater. Residual cancer was found in five (15.6%) of 32 lesions after PEIT and in three (42.9%) of seven lesions after PHoT, but the difference was not statistically significant. Pain tended to be less frequent in patients treated with PHoT than in patients treated with PEIT. We could not determine whether PHoT was superior to PEIT, but our findings indicate that PHoT may be a safe and effective for treating HCC.

Published
1995

6. Relationship of serum 2.5 oligoadenylate synthetase activity during interferon therapy to pretreatment levels or genotypes of serum HCV-RNA

Author

Isao Sakaida, Mitsuru Yasunaga, Keisuke Hino, Kiwamu Okita, Kenji Mori, Kouzou Kayano, Kazuyuki Takenaka, Masafumi Kubota, Aogu Yamashita, Fujio Murakami, Michiari Okuda, and Tomomi Konishi

Subjects
Hepatology, business.industry, 2'-5'-oligoadenylate synthetase activity, Interferon therapy, Virology, Chronic hepatitis, Interferon, Hepatitis C virus RNA, Immunology, Genotype, Medicine, In patient, business, medicine.drug
Abstract

2.5 oligoadenylate synthetase (2.5AS) activity is induced during interferon (IFN) therapy of patients with chronic hepatitis C. It is assumed that the genotype and quantitative level of hepatitis C virus RNA (HCV-RNA) in serum preceding IFN therapy are closely associated with the response to IFN. However, it is not clear whether these viral factors may affect 2.5AS activity during IFN therapy. We analyzed 2.5AS activity during IFN therapy in patients with different genotypes or levels of serum HCV-RNA. However, there were no statistical differences es in 2.5AS activity among them. In the present study, those viral factors were not associated with the induction of 2.5AS activity during IFN therapy, and it is unlikely that differences in response to IFN among patients with different genotypes or quantitative levels of HCV-RNA depend on the 2.5AS pathway.

Published
1994

7. A multicenter study on the prognosis of fulminant viral hepatitis: Early prediction for liver transplantation

Author

Minoru Ukida, Kiwamu Okita, Toshihiko Takeuchi, Yasuyuki Ohta, Yoshitane Kosaka, Hiromitsu Kumada, Shunichi Sato, Kouji Tada, Masao Omata, Kazuhiko Sekiyama, Toshiki Ehata, Katsuhiko Tsukada, Etsuko Hashimoto, Kyuichi Tanikawa, Takashi Kano, Yoshiyata Takahashi, Hiroshi Obata, Yasuhiro Mizoguchi, Mitsuru Yasunaga, Koujiro Takase, Makoto Yoshiba, Ryukichi Kumashiro, Masaru Shimizu, and Takao Tsuji

Subjects
Hepatitis, medicine.medical_specialty, education.field_of_study, Pathology, Hepatology, business.industry, Fulminant, medicine.medical_treatment, Population, Liver transplantation, medicine.disease, Gastroenterology, Transplantation, Internal medicine, medicine, education, Viral hepatitis, Fulminant hepatitis, business
Abstract

To determine the risk of death at an early stage of fulminant viral hepatitis, we created severity indexes drawn from clinical data on the day of development of encephalopathy in 128 patients with fulminant hepatitis B and 103 with fulminant hepatitis non-A, non-B. In fulminant hepatitis B, the risk score was 2.75×BL+2.75×BR+2.7×AG+2.3×WB+1.67×CD+1.56×AL−0.098×PR−0.88, where BL is 1 if total bilirubin is higher than 20 mg/dl, BR is 1 if the ratio of total to direct bilirubin exceeds 2.2, AG is 1 if age is above 40 yr, WB is 1 if white blood cell count is less than 4,000 cells/mm3 or more than 18,000 cells/mm3, CD is 1 if a hazardous disease coexists and AL is 1 if ALT is less than 100 times the upper limit of normal (otherwise all are 0), and PR is prothrombin time (percentage of normal value). Using a cutoff score of 0, we found the positive predictive value, negative predictive value and predictive accuracy to be 0.90, 0.86 and 0.89, respectively. Sensitivity and specificity were 0.94 and 0.77, respectively. In fulminant non-A, non-B hepatitis, the risk score was 2.66×BR+2.25×BL+2.24×DI+2.05×AL ± 1.38×AG+0.00021×WB−6.33. BR is 1 if the ratio of total to direct bilirubin is more than 1.5, BL is 1 if total bilirubin is higher than 15 mg/dl, DI is 1 if the duration of illness before encephalopathy is less than 4 days or more than 12 days, AL is 1 if the ALT level exceeds 40 times the upper limit of normal and AG is 1 if age exceeds 50; otherwise all variables are 0. WB is WBC count per cubic millimeter. Positive predictive value, negative predictive value and predictive accuracy were 0.92, 0.80 and 0.89, respectively. Sensitivity and specificity were 0.95 and 0.70, respectively. These prediction equations were validated prospectively on a population of testing samples comprising 52 patients with fulminant hepatitis B and 47 with fulminant non-A, non-B hepatitis. Positive predictive values were 0.92 and 0.92, negative predictive values were 0.71 and 0.78 and predictive accuracies were 0.87 and 0.89 for patients with fulminant hepatitis B and fulminant non-A, non-B hepatitis, respectively. They may be used for selecting candidates for liver transplantation and for evaluating efficacy of a new therapy. (HEPATOLOGY 1994;19:1065–1071.)

Published
1994

8. Abstracts of selected papers presented at the 79th general meeting of the Japanese Society of Gastroenterology March 29–31, 1993, Kyoto, Japan

Author

Akira Uehara, Masayoshi Namiki, Masashi Yoneda, Yvette Taché, Hidekazu Suzuki, Soichiro Miura, Michiro Otaka, Osamu Masamune, Shin Fukudo, Taisuke Nomura, R. Abe, T. Shimosegawa, Keiya Nakamura, Akira Aoike, Hiroya Yamaguchi, Toshinari Kimura, Toshikazu Nakamura, Kunio Matsumoto, Tomoaki Tomiya, Kenji Fujiwara, Kenji Mori, Mitsuru Yasunaga, Hiroshi Yasuda, Itaru Kojima, Hiroo Ohnishi, Masahito Nagaki, Norio Koide, Takao Tsuji, Kouichi Nagano, Sunao Kawano, Ken Kihira, Kiichi Satoh, Nobuhiro Sakaki, Yoshiya Yamada, Mikio Karita, Tateo Yoshimatsu, Takatoshi Nakashima, Nobuo Aoyama, Yoshihiro Fukuda, Kazutami Tamura, T. Sugiyama, T. Yabana, Jaw-Town Lin, Nobuo Sueoka, Katsuhiko Iwakiri, Sumio Watanabe, Nobuhiro Sato, Kazuaki Yamasaki, Kazuichi Okazaki, Hirokazu Nishino, Tadaki Muroi, Yoshiro Matsuda, Mikihiro Tsutsumi, Masahide Oshita, Yoshiyuki Takei, Ryukichi Kumashiro, Kyuichi Tanikawa, Yasuyuki Nagao, Takeshi Okanoue, Nobuhiro Tsukada, Masaya Oda, Motoyasu Ishii, Takeshi Yamamoto, Masafumi Komatsu, Ko Nakajima, Shotaro Sakisaka, Fumio Itoh, Kohzoh Imai, Yutaka Shintani, Tadao Bamba, Eiichi Saito, Akifumi Ogihara, Masaya Sasaki, Kazuma Fujimoto, Ryuichi Iwakiri, Motonobu Hosomi, Fumio Takada, Makoto Obayashi, Atushi Kitano, Sumiko Nagoshi, T. Tanaka, T. Monna, Yutaka Matsuzaki, Hiroyuki Sugimoto, Hideki Machishi, Ryuji Mizumoto, Kazuya Matsuda, Yoshihito Uchida, H. Okano, N. Aoyama, Masahiko Yamada, Michio Hongo, Yoshihisa Shibata, Masahiko Miyachi, Yuji Nimura, Toshiaki Neya, Masatoshi Mizutani, Jun Inoue, Masahiko Nakamura, Sachiko Futami, K. Funakoshi, K. Sugimura, Yasushi Iwao, Toshifumi Hibi, Kazuo Kusugami, Kimitomo Morise, Mitsuo Kimura, Nobuo Hiwatashi, Shinichiro Kanzaki, Kazuya Makiyama, Makoto Yamamura, Masamichi Satomi, Hirofumi Harada, Hiroshi Shimada, Norimasa Yoshida, Toshikazu Yoshikawa, Hideyuki Hiraishi, Takashi Harada, Masayuki Suzuki, E. Masuda, S. Kawano, H. Matsui, H. Fukutomi, Nobuhide Oshitani, Atsuo Kitano, Makoto Suematsu, Hitoshi Togashi, Haruhide Shinzawa, Hiroya Murakami, Hiroshi Takagi, Hiroshi Kasugai, Masaharu Tatsuta, Takeshi Urabe, Masashi Unoura, Naoki Yamanaka, Eizo Okamoto, Tadatoshi Takayama, Susumu Yamasaki, Kazuhiko Kita, Masaaki Ebara, Yasuo Majima, Osamu Matsui, Hiroshi Demachi, Toshihito Seki, Kyoichi Inoue, Kunihiko Ohnishi, Susumu Ito, Akira Kaneko, Norio Hayashi, Keiichiro Yoneyama, Keiji Mitamura, Katsuyoshi Higashi, Makoto Hoshino, Hisataka Ogasawara, Keigo Sirahama, Naoki Hashimoto, Haruki Yamada, Yasushi Shiratori, Ken’ichi Okano, Masami Minemura, Akiharu Watanabe, Tsutomu Masaki, Masaaki Tokuda, Tatsuyuki Kawano, Mitsuo Endo, Teruo Kouzu, Humiaki Sakaguchi, Nobuyoshi Hanyu, Teruaki Aoki, Chikao Shimamoto, Ichiro Hirata, Koji Sasajima, Kaiyo Takubo, Yukimitsu Kawaura, Kazuyuki Kawakami, Hiroto Hayashi, Takashi Suzuki, Kazuo Watanabe, Hidenobu Watanabe, Naoki Hino, Toshihiro Higashi, Tomohiro Shiro, Yasushi Hongo, Hideki Tada, K. Saitoh, Y. Akiyama, Shoji Mitsufuji, Yasunari Tsuchihashi, K. Nishimura, Y. Hosokawa, Ryo Wada, Kouichi Suda, Ken-ichi Mafune, Yasuo Idezuki, Motowo Mizuno, Mamoru Watanabe, Takayuki Matsumoto, Kenzo Kobayashi, Takeo Yamaguchi, T. Watanabe, Y. Kubota, Akira Andoh, Yoshihide Fujiyama, Kanji Tanaka, Koshirou Hioki, Yuji Hinoda, and Haruo Ohtani

Subjects
medicine.medical_specialty, business.industry, Gastroenterology, Hepatology, medicine.disease, Ulcerative colitis, Colorectal surgery, Fulminant hepatic failure, Surgical oncology, Internal medicine, medicine, Acute pancreatitis, Pancreatitis, business, Abdominal surgery
Published
1993

9. Abstracts of selected papers presented at the 34th annual meeting of the japanese society of gastroenterology

Author

Kazuaki Chayama, Norio Hayashi, Hiromi Tokumura, Masahuru Ohta, Nobuo Hiwatashi, Hiroshi Koyama, Masamichi Satomi, Toshio Tsuyuguchi, Yoshiyasu Karino, Kyuichi Tanikawa, Kaoru Ito, Shigeki Arii, Nobuhide Oshitani, Masayuki Fururawa, Kiyomi Yasuda, Toshio Sawada, Norihito Watanabe, Akira Sugita, Kazuya Makiyama, Tokimune Shibata, M. Atsumi, Yoichi Saitoh, Masahito Miura, Tadao Manabe, Masaaki Ebara, Mitsuru Yasunaga, Takashi Nakamura, Atsuo Kitano, Hiroshi Akimoto, Joe Ariyama, Issei Tachibana, Michio Mito, Shuhei Nishiguchi, Hiroshi Sobajima, Makoto Yamamura, Masaya Oda, Fumio Yamamoto, Masahide Arita, Satoshi Ikei, K. Suzuki, Shotaro Sakisaka, Masanori Hirano, Takeshi Okanoue, Toru Miyahara, Yohei Fukumoto, Shujiro Takase, Fumitake Ishihara, Koji Nakamuta, Yoshihisa Tsukamoto, Motoyasu Ishii, Masahiro Yamamoto, Etsuro Iwashita, Toshihiko Koiwai, Michio Ogawa, Hiroshi Furukawa, Tetsuo Hayakawa, Tsuneo Fukushima, Hisao Oguchi, Yoshihiro Akahane, Toshinari Kimura, Shuichi Sezai, Akitoshi Kakisaka, Hajime Takikawa, Takukazu Nagakawa, T. Kyogoku, Keisho Kataoka, Masami Yamanaka, Susumu Tazuma, and Toshio Nishida

Subjects
medicine.medical_specialty, business.industry, Surgical oncology, Internal medicine, General surgery, Gastroenterology, medicine, Hepatology, business, Colorectal surgery, Abdominal surgery
Published
1993

10. Abstracts of selected papers presented at the 78th general meeting of the Japanese Society of Gastroenterology

Author

Motoyasu Kusano, Toshikazu Sekiguchi, Nobuyoshi Hanyu, Teruaki Aoki, Yasuhiro Matsushima, Eizo Okamoto, Yasuo Takeda, Ryoyu Takeda, Masahiko Miyachi, Yuji Nimura, Taidoh Arai, Jun Masuda, Masao Tanaka, Yoshiaki Ogawa, Kazuhide Ura, Teiji Matsumoto, K. Taniyama, Susumu Kurosawa, Chung Owyang, Hiroshi Baba, Masaki Fujimura, Eiji Hamada, Tadahito Shimada, Teppei Kabemura, Yoshiharu Chijiiwa, T. Sato, K. Koito, Hiroko Matsuda, Tsunehisa Kawasaki, Katsutoshi Obara, Reiji Kasukawa, Hirofumi Miyoshi, Akio Matsumoto, Manabu Yamamoto, Ryouji Ohmasa, Shigehiro Kokubu, Hisao Shibata, Takashi Tajiri, Masahiko Onda, Makoto Hashizume, Keizo Sugimachi, Kenji Kobayashi, Hitoshi Shiozaki, Junko Fujisaki, Tadakazu Shimoda, Satoshi Hase, Yoshihisa Tsukamoto, M. Atsumi, H. Konishi, Shinobu Nakajo, Yoshihide Fujiyama, Masaki Taruishi, Tokiyoshi Ayabe, Kimitomo Morise, Takeo Yamaguchi, Kazuya Makiyama, Minoru Itsuno, T. Matsui, N. Okabe, Nobuo Okabe, Toshiyuki Matsui, Arata Sakatani, Koichi Koizumi, Yutaka Imai, Yoshinori Sugino, Tadahiko Masaki, Toshio Sawada, Takashi Nishigami, Masamichi Satomi, Yasumasa Hatada, Hiroshi Saito, Kiyonori Kobayshi, Tomoe Katsumata, Kenji Sugimoto, Tsukasa Itabashi, Motoji Kitagawa, Tetsuo Hayakawa, Kazuichi Okazaki, Yasuro Yamamoto, Akihiro Funakoshi, Kyoko Miyasaka, Kazuhiko Soejima, Mikio Kanda, Masanori Sugiyama, Akira Kuroda, Hisayuki Inoue, Tadao Bamba, Y. Hamanaka, T. Suzuki, Mamoru Suzuki, Fujio Hanyu, Katsuhiro Tamura, Akira Nakase, M. Noguchi, N. Hiwatashi, Yuhji Murata, Kazuo Suzuki, Haruo Ohtani, Yoshihisa Watanabe, Mikio Zeniya, Yoshio Aizawa, T. Masumoto, M. Onji, Keisuke Hamasaki, Keisuke Nakata, Hiroshi Fukui, Tadasu Tsujii, Masayoshi Yamashiki, Akira Nishimura, Hiroko Tsutsui, Yasuhiro Mizoguchi, Fumio Kimura, Masaru Miyazaki, Keisuke Kiyota, Hideto Inokuchi, Yoshihiro Yamamoto, Hiroshi Oka, Tsutomu Horikoshi, H. Takayasu, T. Shirai, Michio Hongo, Yo Okuno, H. Okano, N. Aoyama, Masao Ohsuki, Kenji Maeda, Ken Haruma, Koji Sumii, Yoshihide Nakai, Mikihiko Fukunaga, Hiroshi Kaneko, Toshikatsu Okumura, Akira Uehara, Yoshihiro Fukuda, Takashi Joh, Makoto Itoh, Yuko Kitagawa, Masaki Kitajima, Tadashi Iwao, Atsushi Toyonaga, Masahiko Nakamura, Masaya Oda, Yukimitsu Kawamura, Kenji Dohden, Yasuhiko Kamiyama, Seiki Matsuno, Morihisa Hirano, Sachio Otsuka, Masahiro Ito, Ichiro Sekine, Tatsuo Ogihara, Nobuhiro Sato, Masayoshi Namiki, Nobuyuki Sugiura, Masaaki Ebara, Naoki Matsuo, Hideo Uchida, Shuichi Okada, Nobuo Okazaki, Hirohiko Tsujii, Toshiaki Ohsuga, M. Abe, Y. Nagata, Susumu Yamasaki, Tomoo Kosuge, Mikiya Kitamoto, Toshio Nakanishi, Yuzo Ichikawa, Yoshio Ohtake, Hiroyuki Hirasawa, Junichi Sugihara, Yasutoshi Muto, Mitsuru Yasunaga, Kiwamu Okita, Minoru Ukida, Takao Tsuji, Hideya Isai, Junichi Uchino, Katsuhiko Suzuki, Kanji Komatsu, Yumiko Ohtomo, Yasuo Idezuki, Shunji Sakuramachi, Taizo Kimura, Seigo Kitano, Masaaki Moriyama, Yasuyuki Yazaki, and Takashige Saito

Subjects
medicine.medical_specialty, business.industry, Surgical oncology, Internal medicine, General surgery, Gastroenterology, Medicine, Hepatology, business, Colorectal surgery, Abdominal surgery
Published
1993

11. Abstracts of selected papers presented at the 33rd Annual Meeting of the Japanese Society of Gastroenterology

Author

Tomonobu Hasuo, Tohzo Hosoi, M. Nagano, F. Motizuki, Miwako Arima, Teruo Kouzu, Yoko Murata, Hiroko Ide, Hitoshi Shiozaki, Kenji Kobayashi, Tatsuyuki Kawano, Mitsuo Endo, Shohei Koyama, Hirohiko Tsujii, Fukuo Kondo, Masaaki Ebara, Osamu Nakashima, Masamichi Kojiro, Tadatoshi Takayama, Masatoshi Makuuchi, Fumie Kurokawa, Kiwamu Okita, Yoshinobu Itoh, Kouichi Akamatsu, Sachiko Tanaka, Tsugio Kitamura, Kenji Ikeda, Hiromitsu Kumada, Yasuo Majima, Kyuichi Tanikawa, Shingi Imaoka, Yo Sasaki, Yasuo Ohkura, Kyoichi Nakamura, Masahiko Hirakawa, Tadahiko Fuchigami, Sumio Tsuda, Toshiyuki Matsui, Osamu Tsuruta, Nobuyuki Arima, Takashi Ohishi, Naoto Egawa, Toshio Sawada, Tetsuichiro Muto, Michio Sata, Shujiro Takase, Mikihiro Tsutsumi, Toshiyuki Uchikoshi, Shiro Maeyama, M. Unoura, S. Kaneko, Kendo Kiyosawa, Eiji Tanaka, Shuhei Nishiguchi, Tetsuo Kuroki, null Hosoda, Yoshimi Ito, Kiyomi Yasuda, Koichi Tashima, Yasuyuki Ohta, Yukinori Okazaki, Yasuhiko Miyoshi, Junji Yoshino, Saburo Nakazawa, Kiyoshi Ashida, Masahiro Sakaguchi, Shuichi Ohara, Shigeru Asaki, Hideo Ise, Seiki Matsuno, Shun-ichi Higashide, Kazutomo Inoue, Teiji Matsumoto, Tsukasa Tsunoda, S. Moriizumi, T. Shimosegawa, Norio Sawabu, Yoshitake Satomura, Aiji Noda, Eri Ibuki, M. Atsumi, K. Kashima, Kazuhiro Omagari, Atsushi Toyonaga, Yoshihisa Takasaki, Tomoko Muranaga, Masahiro Tada, Atsushi Murakami, Ken Kihira, Yukio Yosida, Ken Kimura, Yasuhiro Miyazaki, Masanori Hirao, Kazuhiko Inoue, Tohru Hidaka, Osami Inoue, Hiroshi Yatsuhashi, Michio Kaminishi, Shouji Shimoyama, Michiko Takahashi, Gotaro Yamada, Susumu Takano, Masao Omata, Nobuyasu Ito, Yukihiko Tameda, T. Kondo, S. Sainokami, Yasuji Arase, Takeshi Seki, Mitsuru Yasunaga, Kazutosi Sanuki, Tomoaki Tomiya, Kenji Fujiwara, Kouji Tada, Yoshio Ohtake, Hiroyuki Hirasawa, Kazuyuki Suzuki, Shunichi Sato, Hiroaki Takahashi, Ryuji Mizumoto, Akira Aoike, Kazuhiko Watanabe, Osahumi Yamaguti, Hajime Kuwayama, Hitoshi Asakura, Rintaro Narisawa, Ryukichi Kumashiro, Yoshitsugu Kubota, Kyoichi Inoue, Tokimune Shibata, Tetsuo Hayakawa, and Takanori Hattori

Subjects
medicine.medical_specialty, business.industry, General surgery, Gastroenterology, Hepatology, Colorectal surgery, Strip biopsy, Early Gastric Cancer, Pancreatic stone, Surgical oncology, Internal medicine, Medicine, business, Abdominal surgery
Published
1993

12. Effects of secretin on bile production in two kinds of cholestatic models by choledocho-caval fistula and bile duct ligation in rats

Author

Kiwamu Okita, Yohei Fukumoto, Michiari Okuda, Mitsuru Yasunaga, and Masaya Ando

Subjects
Male, Cholagogues and Choleretics, medicine.medical_specialty, Bile Duct Epithelium, Fistula, medicine.medical_treatment, Cholestasis, Intrahepatic, digestive system, Gastroenterology, Secretin, Bile Acids and Salts, Excretion, fluids and secretions, Cholestasis, Internal medicine, medicine, Animals, Bile, Saline, Bile duct, business.industry, Rats, Inbred Strains, Cholestasis, Extrahepatic, medicine.disease, Rats, Major duodenal papilla, Bicarbonates, medicine.anatomical_structure, Endocrinology, Bile Ducts, business, hormones, hormone substitutes, and hormone antagonists
Abstract

Secretin is known to stimulate bile flow from the bile duct epithelium. To investigate the effects of secretin in cholestasis, we studied the response of the bile flow and the excretion of biliary components to secretin using two cholestatic models with or without damage to the bile duct epithelium. The model without bile duct epithelial damage was a choledocho-caval (CC) fistula over a 24-hour period, and the model with bile duct damage was a bile duct ligation over a 48-hour period. Secretin was administered by intravenous infusion for 30 minutes and bile was collected for 120 minutes. Controls were given saline similarly. The bile flow and biliary bicarbonate excretion rate were significantly increased after secretin infusion in the CC fistula rats when compared with the control rats, but no stimulation by secretin was observed in the ligated rats. These data indicate that secretin-induced bile production was enhanced under cholestatic conditions with no bile duct epithelial disturbance.

Published
1992

13. Clinical investigations on the levels of serum TNF-.ALPHA. in the patients with acute liver injury

Author

Kazutoshi Sanuki, Hiroyuki Shirasawa, Kenji Mori, Kiwamu Okita, Masahumi Kubota, Keisuke Hino, Mitsuru Yasunaga, Michiair Okuda, Fukumoto Y, Kozo Kayano, Kazuyuki Takenaka, Isao Sakaida, Aogu Yamashita, and Satoyoshi Yamashita

Subjects
Acute liver injury, medicine.medical_specialty, Hepatology, business.industry, Internal medicine, Medicine, Tumor necrosis factor alpha, business, Gastroenterology
Published
1992

14. Clinical significance of serum level of thrombomodulin in several liver diseases: especially in acute liver failure

Author

Kazuyuki Takenaka, Michiari Okuda, Mitsuru Yasunaga, Aogu Yamashita, Masafumi Kubota, Kiwamu Okita, Satoyoshi Yamashita, Fukumoto Y, Kozo Kayano, Kazutoshi Sanuki, Hiroyuki Shirasawa, Isao Sakaida, and Kenji Mori

Subjects
medicine.medical_specialty, Hepatology, medicine.diagnostic_test, business.industry, Internal medicine, Liver failure, medicine, Clinical significance, Thrombomodulin, business, Liver function tests, Gastroenterology
Published
1992

15. Evaluation of Laparoscopic Findings in Chronic Hepatitis C

Author

Keisuke Hino, Masaya Ando, Tomomi Konishi, Mitsuru Yasunaga, Michiari Okuda, Yohei Fukumoto, Kiwamu Okita, Satoyoshi Yamashita, Tetsuya Furukawa, and Hiroyuki Shirasawa

Subjects
Hepatitis, medicine.medical_specialty, Pathology, Cirrhosis, medicine.diagnostic_test, business.industry, Gastroenterology, Hepatitis C, Hepatitis B, medicine.disease, Chronic hepatitis, Internal medicine, Lymphoid follicle, Biopsy, Medicine, Hepatocellular necrosis, Radiology, Nuclear Medicine and imaging, business
Abstract

To elucidate the differences in the progression of liver cirrhosis of chronic hepatitis B and C, the laparoscopic appearance of the liver surface and the histological findings were carefully assessed in 65 patients with chronic hepatitis B and 58 patients with chronic hepatitis C. There was a difference noted in the distribution of periportal reddish markings between the two types of chronic hepatitis. Localized and irregular markings were found to be common in hepatitis C. While the markings were seen to be diffusely distributed over the liver surface in hepatitis B. In addition, localized and longitudinal depressions on the liver surface were observbed more frequently in the hepatitis C patients than in those with hepatitis B. Biopsy specimens obtained from the hepatitis C patients with the above-mentioned laparoscopic findings showed more advanced histological activity. These laparoscopic changes developed in accordance with the progression of histological activity in chronic hepatitis C. Lymphoid follicles or aggregates within the portal areas were observed more frequently in the patients with chronic hepatitis C than in the chronic hepatitis B patients. Although it is not yet clear how the laparoscopic and histological differences between these two types of chronic hepatitis come about, it appears that the progression of hepatocellular necrosis in chronic hepatitis C is different from that of chronic hepatitis B.

Published
1991

16. Abstracts of selected papers presented at the 30th Annual Meeting of the Japanese Society of Gastroenterology October 20–22, 1988 — Kagoshima, Japan

Author

Ichiro Oda, Kaoru Ogawa, Shuichi Okada, Keiichi Ueno, Tohru Itoh, Yuji Horiguchi, Hiroshi Kijima, Kazuo Inui, Akitoshi Koga, Tetsuro Hamamoto, Hideaki Tsukada, Takashi Tamada, Takahiko Nakamura, T. Okanoue, Daisuke Koike, Hirohiko Abe, Tsutomu Miura, Shuji Hashimoto, M. Oda, T. Azuma, Shigeyuki Nagata, Hiromasa Ishii, Norifumi Kawada, Yasuhiro Mizoguchi, Yuji Yoshikawa, Hiroshi Oka, Takafumi Ichida, Fumihiro Ichida, Takato Ueno, Kyuichi Tanikawa, Norihiro Kokudo, Seiji Kawasaki, Morikazu Onji, Hiroaki Miyaoka, Osamu Yokosuka, Masao Omata, Hiroshi Ikeda, Takao Tsuji, Shigeki Hayashi, Kenji Fujiwara, Mitsuru Yasunaga, Kiwamu Okita, Koujirou Takase, Yukihiko Tameda, Hiroo Ohnishi, Jun-ichi Sugihara, Hideo Kojima, Tomoteru Kamimura, Eiji Tanaka, Hidetoshi Yoda, Atsushi Kanno, Masao Ohtsuki, Yasuji Miyata, Shunichi Koga, Masashi Unoura, Nobuyoshi Tanaka, Takahiro Kodama, Hideo Nishimura, Kazuyuki Suzuki, Takeo Madarame, Masafumi Komatsu, Shunji Ookubo, Masataka Nishiyama, Shozo Saito, Ryukichi Kumashiro, Kenji Ikeda, Hiromitsu Kumada, Shuhei Nishiguchi, Tetsuo Kuroki, Makoto Yoshiba, Yukari Takeuchi, Takao Morito, Reiji Kasukawa, Isao Takeda, Satoshi Nakano, Kenzo Matsumura, Tomohiro Imanari, Shigeki Lee, Naotaka Fujita, Tetsuya Mine, Eiichi Sato, Masafumi Suyama, Jo Ariyama, Toshihisa Takahashi, Masanori Hirano, Atsushi Hirai, Tatsuo Yamakawa, Junichi Kamiya, Yuji Nimura, Hideo Yoshimoto, Seiyo Ikeda, Tadashi Yamasuji, Keizo Saeki, Masaki Itoh, Goro Kajiyama, Hideichi Seki, Ken Kimura, Hiroshi Nakamura, Yukihiro Tsuchiya, Ryosuke Omura, Shinya Tanaka, Katsuhide Shimakura, Yoshiaki Matsuda, Tokio Wakabayashi, Hideo Morimoto, Yasutaka Kamiya, Yasutaka Okayama, Masao Kobayashl, Sotaro Fujimoto, Atsumasa Yamaguchi, Tadashi Shibue, Ryukichi Akashi, Masahiro Hattori, Yasunori Takehira, Yasutoshi Tsugane, Yoshinori Tashiro, Hajime Kuwayama, Yoichi Kon, Tsugio Higuchi, Nobuto Hirata, Tomoyuki Kano, Kumiko Kurimoto, Y. Kubota, T. Seki, Yoshimine Kamura, Toshimichi Nakayama, Hitoshi Yoshimura, Tetsuya Yoshioka, Kimihiko Akimoto, Hirohide Ohnishi, Etsuro Ogata, Atsushi Igarashi, Atsushi Kadowaki, Tsutomu Yaoita, Naoki Sato, Kimitsune Monma, Hiroaki Kogure, Yoshio Tajima, Hideki Takanashi, Kazuo Haniya, Masao Ohto, Ikuo Murata, Takashi Tanaka, Takashi Sakabe, Takashi Kato, Tadashi Koike, Tetsuya Watanabe, Tetsuo Nakamura, H. Kato, I. Ikai, N. Nishimura, N. Kobayashi, K. Ozawa, Katsuyuki Ono, Michio Sata, Ken Kadowaki, Jiro Ikoma, Yuji Kojima, Tetsuya Murata, Ryuichi Kakehashi, Toshio Ibe, Uichiro Kano, Tetsuo Ito, Takeshi Tanaka, Shozo Watanabe, Shiro Suzuki, Osamu Nakazawa, Kyuhei Kohda, Kohzo Ohyama, Shoki Terada, Katsuhiko Sazaki, Teikichi Kure, Koetsu Morita, Osamu Shida, Hiroshi Muramatsu, Yoshiro Niitsu, Shinichi Tozuka, Yoshinori Sakai, Takaaki Ikeda, Wataru Koyama, Shigemi Sakamoto, Masaaki Kanayama, Naohide Tanaka, Yasuyuki Arakawa, Yutaka Matsuo, Kouichi Takaguchi, Gotaro Yamada, Kazuharu Matsuura, Hirosi Ikeda, Yoshiaki Iwasaki, Kazuhiro Nouso, Kazuhiro Matsueda, Masahiko Sawahara, Shigeatsu Fujiki, Motowo Mizuno, Shingo Kino Yama, Seijin Nadano, Norio Horiike, Kojiro Michitaka, Izumi Kumon, Yasushi Ogawa, Shuji Yamaguchi, Yasuyuki Ohta, Masaaki Nishi, Yasushi Matsuzaki, Naomi Tanaka, Hisashi Matsumoto, Yoshimichi Chuganji, Toshiaki Osuga, S. Shoji, M. Kurata, M. Wakashima, Y. Itoh, M. Hagiri, T. Kondou, M. Katayama, K. Nishizawa, H. Takikawa, H. Ohsawa, M. Miyake, M. Yamanaka, Teruji Ooka, Masahiko Akita, Hogen Kim, Michio Kato, Manabu Masuzawa, Takumasa Okuyama, Masahiko Akiyama, Yoshitaka Ishigami, Kazuya Tamura, Osamu Fukui, Hiroshi Abe, Takenobu Kamada, Ken Arai, Michiko Shindo, Tadao Okuno, Masayuki Matsumoto, Makoto Takeda, Tatsuro Takino, Yoshihiro Sokawa, M. Omata, O. Yokosuka, Y. Ito, K. Hosoda, M. Ohto, Yoshinobu Fuse, Tadashi Kodama, Kenji Sugiyama, Shinobu Nakajo, Shin Ajitsu, Tsuneo Takahashi, K. Kuroe, Y. Murata, and Hideo Ikeda

Subjects
Gerontology, medicine.medical_specialty, Surgical oncology, business.industry, Internal medicine, General surgery, Gastroenterology, medicine, Hepatology, business, Colorectal surgery, Abdominal surgery
Published
1990

17. The effect of E3330 on active oxygen generation by isolated hepatic macrophages in rats

Author

Kiwamu Okita, Mitsuru Yasunaga, Shuji Wasaki, Atsuko Nagatomi, Yasuhiro Matsumura, and Isao Sakaida

Subjects
Lipopolysaccharides, Male, medicine.medical_specialty, Necrosis, Gastroenterology, Propionibacterium acnes, Text mining, Surgical oncology, Internal medicine, Benzoquinones, medicine, Animals, Rats, Wistar, Propionates, biology, business.industry, Macrophages, Hepatology, biology.organism_classification, Colorectal surgery, Rats, Oxygen, Liver, medicine.symptom, business, Abdominal surgery
Published
1995

18. Protective effect of deferoxamine for acetaminophen induced liver injury

Author

Kazuyuki Takenaka, Mitsuru Yasunaga, Kozo Kayano, Masafumi Kubota, Isao Sakaida, K Okita, and Kenji Mori

Subjects
Male, medicine.medical_specialty, Deferoxamine, Pharmacology, Lipid peroxidation, Necrosis, chemistry.chemical_compound, Internal medicine, medicine, Animals, Acetaminophen, Liver injury, Dose-Response Relationship, Drug, business.industry, Gastroenterology, Rats, Inbred Strains, Hepatology, medicine.disease, Rats, Liver, chemistry, Anesthesia, business, medicine.drug
Published
1992

19. Therapy of intrahepatic cholestasis with secretin

Author

Mitsuru Yasunaga, Kiwamu Okita, and Yohei Fukumoto

Subjects
medicine.medical_specialty, Hepatology, Cholestasis, business.industry, Internal medicine, medicine, medicine.disease, business, Gastroenterology, Secretin
Published
1991

20. Choice of conservative therapeutic modalities for hepatocellular carcinoma

Author

Keiki Ogino, Hiroshi Nawata, Mitsuru Yasunaga, Keijiro Ando, Takahiro Kodama, Toshinori Harada, Kiwamu Okita, Yasushi Shingai, Yuji Kado, and Tadayoshi Takemoto

Subjects
Oncology, medicine.medical_specialty, Pathology, Hepatology, business.industry, Hepatocellular carcinoma, Internal medicine, Medicine, business, medicine.disease, Therapeutic modalities
Abstract

われわれは自験肝細胞癌309例を対象とし内科的治療法の評価を行い,治療法の選択について検討した.309例に対する治療法の内訳は肝切除術(22例),肝動脈塞栓術(TAE)(35例),lipiodolization(32例),one-shot療法(140例),無治療あるいは抗癌剤全身投与(80例)である.また11例にインターフェロンγ療法を行った.症例はclinical stage (CS), tumor stage (TS), portal invasion (Vp)により3～4stageに分類した.TAE, lipiodolization, one-shot療法等activeな治療法はCS I～II, TS I～II, Vp 0～3で有効であり有効性もその順に認められたがCS III, TS III, Vp 4では延命効果はほとんど期待できなかった.またインターフェロンγ療法は投与後NK活性が上昇することから全身療法の一つとなる可能性が示唆された.

Published
1986

21. 3 cases of HBsAg carrier with fulminant liver failure induced by withdrawal of steroid therapy

Author

Hiroko Tanaka, Keisuke Hino, Tadayoshi Takemoto, Mitsuru Yasunaga, Fukumoto Y, Hiroyuki Shirasawa, Yasuji Shinkai, Satoyoshi Yamashita, Kiwamu Okita, Tomomi Konishi, Fujio Murakami, and Kazutoshi Sanuki

Subjects
medicine.medical_specialty, Steroid therapy, Endocrinology, Hepatology, business.industry, Internal medicine, medicine, Hbsag carrier, business, Fulminant liver failure, Gastroenterology
Abstract

肝疾患以外に対してステロイド療法を施行し,その減量または中止後に肝炎を発症し,劇症化し死に至ったasymptomatic HBs Ag carrierの3症例を報告した.ステロイド投与による免疫能の抑制と,その後の中止または漸減による免疫能の過剰な賦活が,肝炎を劇症化させたと考えられた.B型慢性肝炎に対するステロイド離脱療法後の肝炎の重症化も報告されており,HBs抗原陽性者にステロイドを使用する際は充分な注意が必要である.ステロイド療法は各領域でしぼしば施行されており,このような症例の特徴を広く各領域の医療担当者に認識させることの重要性を指摘した.

Published
1988

22. Two cases of acute liver injury caused by ingesting small dose of acetoaminophen

Author

Tadayoshi Takemoto, Tetsuro Handa, Yuji Kado, Masaaki Ogino, Kenichi Noda, Yasushi Shinkai, Mitsuru Yasunaga, Shoshi Matsuda, Yohei Fukumoto, Kiwamu Okita, Hiroshi Nawata, and Makoto Murata

Subjects
Acute liver injury, medicine.medical_specialty, Hepatology, business.industry, Internal medicine, Medicine, business, Gastroenterology
Abstract

アセトアミノフェンの大量服用により,急性肝障害の発症をみることは,よく知られた事実である.最近,教室では,少量のアセトアミノフェンの服用にもかかわらず,重症肝障害を生じた2例を経験したので報告した.患者は38歳の男性と31歳の女性である.アセトアミノフェン服用量は,それぞれ,3.7gと6.4gで,いずれも嘔吐,腹痛,全身倦怠感を訴えて入院した.本剤服用時,前者はアルコールを摂取し,後者は絶食状態であった.検査上,前者は著明な血清トランスアミナーゼの上昇,軽度の黄疸を認め,心内膜炎,腎障害,急性膵炎を併発し,肝組織では小葉内に巣状壊死が散在し,中心静脈周囲にも壊死が認められた.後者でも重篤な肝障害と血小板減少がみられ,肝組織像はbridging necrosisを示していた.アルコール摂取と絶食のために,少量のアセトアミノフェン服用にもかかわらず,予想以上に肝障害が重症化したと考えられ,本剤の使用にあたり,注意が必要である.

Published
1985

23. A new therapeutic trial of secretin in the treatment of intrahepatic cholestasis

Author

Masaya Ando, Tomomi Konishi, Yohei Fukumoto, Mitsuru Yasunaga, Tadayoshi Takemoto, Tadasu Fuji, Takahiro Yamasaki, Kiwamu Okita, and Hiroyuki Shirasawa

Subjects
Adult, Male, medicine.medical_specialty, Choleretic, Cholestasis, Intrahepatic, digestive system, Gastroenterology, Secretin, fluids and secretions, Cholestasis, Liver Function Tests, Internal medicine, medicine, Humans, Insulin, Aged, Clinical Trials as Topic, medicine.diagnostic_test, Common bile duct, business.industry, Bilirubin, Jaundice, Middle Aged, medicine.disease, Glucagon, medicine.anatomical_structure, Phenobarbital, Drainage, Female, medicine.symptom, business, Liver function tests, hormones, hormone substitutes, and hormone antagonists, medicine.drug, Hormone
Abstract

Many animal experiments have been studied on the choleretic effects of secretin. We intended to estimate secretin choleresis in human (15 patients) who had received PTCD or T-tube insertion into the common bile duct. Based upon these data of secretin and choleresis, secretin was administered to 11 patients with prolonged jaundice due to intrahepatic cholestasis in order to evaluate this as a new therapy for intrahepatic jaundice. As controls, eleven patients with intrahepatic cholestasis treated with steroid hormones and/or phenobarbital were used. In all cases with biliary drainage, secretin produced a remarkable choleretic effect with a high concentration of bicarbonate. In 9 out of 11 patients with intrahepatic cholestasis who were treated with secretin, levels of serum bilirubin decreased linearly and other liver function tests returned to the normal range. The mean values of T1/2 (number of days required for reduction by half) of serum bilirubin in 9 effective cases to secretin was 10.8 days. On the other hand, that in 11 effective cases treated with steroid hormones and/or phenobarbital was 23.2 days. These results suggest that secretin therapy may be an effective treatment for intrahepatic cholestasis.

Published
1989

24. Clinical evaluation of glucagon and insulin in therapy of fulminant hepatitis

Author

Kazutoshi Sanuki, Tadayoshi Takemoto, Mitsuru Yasunaga, Shoshi Matsuda, Kiwamu Okita, and Tetsuro Hanta

Subjects
Adult, Male, medicine.medical_specialty, Combination therapy, medicine.medical_treatment, Prednisolone, Exchange Transfusion, Whole Blood, Glucagon, Hepatitis, Fulminant hepatic failure, Internal medicine, medicine, Humans, Insulin, Fulminant hepatitis, Infusions, Intravenous, business.industry, Gastroenterology, Plasmapheresis, Endocrinology, Regular insulin, Drug Therapy, Combination, Female, business, medicine.drug
Abstract

Forty five patients were examined in order to evaluate the usefulness of glucagon and insulin as a therapy of fulminant hepatitis. Thirty patients were treated with simultaneous infusion of glucagon and insulin, whereas prednisolone was given at a daily dose of 60 to 90 mg in 15 cases. In the former group, 1 mg of glucagon and 10 units of regular insulin were infused over a period of 2 to 6 hours. Two such treatments were given per day in the early critical period of fulminant hepatitis. The therapeutic effect of glucagon and insulin was evaluated in comparison with that of prednisolone, and additionally, with a combination therapy of either blood exchange or plasmapheresis in both groups. The survival rate was superior in the group treated with glucagon and insulin (46%) and in the one with combined infusion of these hormones plus plasmapheresis (33%).

Published
1987

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