1. Effects of diode low-level laser therapy on healing of tooth extraction sockets: a histopathological study in diabetic rats
- Author
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Zahra Delavarian, Hossein Alavi, Narges Ghazi, Mina Davaji, Zohreh Dalirsani, Reyhaneh Shafieian, Habibollah Esmaily, Hamideh Salari Sedigh, and Atessa Pakfetrat
- Subjects
Male ,Molar ,medicine.medical_treatment ,Dentistry ,Dermatology ,Diabetes Mellitus, Experimental ,030207 dermatology & venereal diseases ,03 medical and health sciences ,0302 clinical medicine ,Laser therapy ,Diabetes mellitus ,Animals ,Medicine ,Low-Level Light Therapy ,Rats, Wistar ,Tooth Socket ,Low level laser therapy ,Dental alveolus ,Wound Healing ,business.industry ,030206 dentistry ,medicine.disease ,Rats ,Osteoid Formation ,Tooth Extraction ,Surgery ,Lasers, Semiconductor ,business ,Wound healing - Abstract
Diabetes mellitus is mostly interrelated to deficiency in wound healing. Low-level laser therapy has been shown to exert reliable effects on the acceleration of wound healing process. This study aimed to determine the potential influence of low-level laser therapy (LLLT) on the healing of extraction sockets in diabetic rats. A total of 24 healthy male Wistar rats were selected for this study. After diabetes induction, the maxillary first molars of all rats were extracted bilaterally. Then, the animals were subjected either to Ga-Al-As laser at 808 nm or to Al-Ga-In-P laser at 660 nm at the right extracted socket every day for the next 14 days. The left sockets served as controls. Rats were sacrificed on the 3rd, 5th, 7th, and 14th days after tooth extraction. The samples were examined by a pathologist. LLLT at 808 nm was able to significantly repress inflammation, improve osteoid formation, and promote vascularization in comparison to the non-treated sockets. LLLT at 660 nm significantly suppressed inflammation and developed vascularization in comparison to the non-treated sockets, but failed to improve osteoid formation in the treated sockets. This study suggests that LLLT could be considered as a reliable treatment for wound healing in diabetic experimental rats.
- Published
- 2021
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