1. Effectiveness and safety of repeat dexamethasone for bronchopulmonary dysplasia
- Author
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Greta Ciccolari-Micaldi, An-Lin Cheng, Alain Cuna, Kevin J. Varghese, Anastasia Quiqley, William E Truog, Christian Oliveros, and Michael Norberg
- Subjects
medicine.medical_specialty ,Gastroenterology ,Dexamethasone ,Article ,03 medical and health sciences ,0302 clinical medicine ,030225 pediatrics ,Internal medicine ,Respiratory signs and symptoms ,medicine ,Weaning ,Humans ,Infant, Very Low Birth Weight ,030212 general & internal medicine ,Adverse effect ,Bronchopulmonary Dysplasia ,Retrospective Studies ,Respiratory tract diseases ,business.industry ,Adverse effects ,Infant, Newborn ,Obstetrics and Gynecology ,Infant ,Retrospective cohort study ,medicine.disease ,Respiratory support ,Head circumference ,Bronchopulmonary dysplasia ,Outcomes research ,Pediatrics, Perinatology and Child Health ,business ,medicine.drug - Abstract
Objective: To describe effectiveness of repeat dexamethasone for bronchopulmonary dysplasia (BPD) and to evaluate adverse effects on growth. Study design: Retrospective study of infants treated with 1 or 2 courses of dexamethasone for BPD. Effectiveness was defined as successful step-down in respiratory support by end of treatment. Adverse effects on growth were analyzed and compared to untreated controls. Results: A total of 132 dexamethasone-treated infants were identified. In total, 52% (69/132) of infants treated with initial dexamethasone achieved step-down in respiratory support compared to 38% (20/52) of infants with repeat dexamethasone. Growth trajectory did not significantly differ among infants treated with 1 or 2 courses of dexamethasone compared with controls (weight: P = 0.23, length: P = 0.68, and head circumference: P = 0.77). Conclusions: Repeat dexamethasone for BPD was less effective in weaning respiratory support compared to initial course. Changes in growth parameters to discharge were comparable between controls and infants treated with 1 or 2 dexamethasone courses.
- Published
- 2021