1. 31P Magnetic Resonance Spectroscopy in Patients With Various Genesis of Left Ventricular Hypertrophy
- Author
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Sergey K. Ternovoy, Mazaev Vv, Serova Ns, and Stukalova Ov
- Subjects
Male ,medicine.medical_specialty ,Magnetic Resonance Spectroscopy ,Phosphocreatine ,Group ii ,Energy metabolism ,Left ventricular hypertrophy ,chemistry.chemical_compound ,Adenosine Triphosphate ,Cardiac magnetic resonance imaging ,Internal medicine ,Medicine ,Humans ,In patient ,medicine.diagnostic_test ,business.industry ,Myocardium ,Hypertrophic cardiomyopathy ,Nuclear magnetic resonance spectroscopy ,Middle Aged ,medicine.disease ,chemistry ,Cardiology ,Female ,Hypertrophy, Left Ventricular ,Cardiology and Cardiovascular Medicine ,business ,Energy Metabolism - Abstract
PURPOSE to assess status of myocardial energy metabolism in patients with different etiology of left ventricular hypertrophy by phosphorus magnetic resonance spectroscopy (MRS) compared with healthy individuals. METHODS The study included 94 people: 30 healthy volunteers (group 1), 35 patients with arterial hypertension and left ventricular hypertrophy (group II), 29 patients with hypertrophic cardiomyopathy (group III). All persons underwent cardiac magnetic resonance imaging (MRI) and MRS on high field MR scanner. Energy metabolism index (ratio of phosphocreatine and adenosine triphosphate concentrations [Pcr/ATP]) was used for evaluation of myocardial energy metabolism. RESULTS Values of Pcr/ATP were 2.11 ± 0.29, 1.65 ± 0.12, and 1.32 ± 0.16 in groups I, II, and III, respectively (p < 0.05). CONCLUSION 31P MRS is an effective tool of detection of disordered energy metabolism in hypertrophic myocardium. Combined use of MRI and MRS can become an effective method of comprehensive study of the heart.
- Published
- 2016