1. Characteristic of COVID-19 infection in pediatric patients: early findings from two Italian Pediatric Research Networks
- Author
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M. Romanengo, Annamaria Magista, M. Chiossi, Marco Binotti, Rino Agostiniani, Maria Antonietta Barbieri, Egidio Barbi, Serena Arrigo, L. Verdoni, Marcello Lanari, M. Raggi, Alberto Arrighini, Enrico Felici, Barbara Cantoni, R. Giacchero, Elisabetta Miorin, L. Da Dalt, Matteo Lenge, Anna Maria Musolino, F. Nicoloso, Niccolò Parri, Federico Marchetti, Stefano Masi, B. Covi, Ilaria Mariani, E. Zoia, Antonio Francesco Urbino, Danilo Buonsenso, Chiara Pilotto, Anna Plebani, Benedetta Armocida, Silvia Fasoli, Marzia Lazzerini, Paolo Biban, Parri, N., Magista, A. M., Marchetti, F., Cantoni, B., Arrighini, A., Romanengo, M., Felici, E., Urbino, A., Da Dalt, L., Verdoni, L., Armocida, B., Covi, B., Mariani, I., Giacchero, R., Musolino, A. M., Binotti, M., Biban, P., Fasoli, S., Pilotto, C., Nicoloso, F., Raggi, M., Miorin, E., Buonsenso, D., Chiossi, M., Agostiniani, R., Plebani, A., Barbieri, M. A., Lanari, M., Arrigo, S., Zoia, E., Lenge, M., Masi, S., Barbi, E., Lazzerini, M., Parri N., Magista A.M., Marchetti F., Cantoni B., Arrighini A., Romanengo M., Felici E., Urbino A., Da Dalt L., Verdoni L., Armocida B., Covi B., Mariani I., Giacchero R., Musolino A.M., Binotti M., Biban P., Fasoli S., Pilotto C., Nicoloso F., Raggi M., Miorin E., Buonsenso D., Chiossi M., Agostiniani R., Plebani A., Barbieri M.A., Lanari M., Arrigo S., Zoia E., Lenge M., Masi S., Barbi E., and Lazzerini M.
- Subjects
Adolescents ,COVID-19 ,Children ,Italy ,Male ,Pediatrics ,Conscious Sedation ,Disease ,Comorbidity ,Clinical Laboratory Technique ,01 natural sciences ,law.invention ,0302 clinical medicine ,COVID-19 Testing ,law ,Risk Factors ,Retrospective Studie ,Hypnotics and Sedatives ,030212 general & internal medicine ,Viral ,Child ,Intensive care unit ,Treatment Outcome ,Child, Preschool ,Female ,medicine.symptom ,Coronavirus Infections ,Cohort study ,Human ,medicine.medical_specialty ,Respiratory Therapy ,Neuromuscular disease ,Adolescent ,Short Communication ,Pneumonia, Viral ,Asymptomatic ,03 medical and health sciences ,Betacoronavirus ,Clinical Laboratory Techniques ,Humans ,Infant ,Infant, Newborn ,Pandemics ,Retrospective Studies ,SARS-CoV-2 ,medicine ,Pediatrics, Perinatology, and Child Health ,0101 mathematics ,Risk factor ,Preschool ,Pandemic ,business.industry ,Coronavirus Infection ,Risk Factor ,010102 general mathematics ,Retrospective cohort study ,Pneumonia ,medicine.disease ,Newborn ,Reading ,Pediatrics, Perinatology and Child Health ,business - Abstract
Detailed data on clinical presentations and outcomes of children with COVID-19 in Europe are still lacking. In this descriptive study, we report on 130 children with confirmed COVID-19 diagnosed by 28 centers (mostly hospitals), in 10 regions in Italy, during the first months of the pandemic. Among these, 67 (51.5%) had a relative with COVID-19 while 34 (26.2%) had comorbidities, with the most frequent being respiratory, cardiac, or neuromuscular chronic diseases. Overall, 98 (75.4%) had an asymptomatic or mild disease, 11 (8.5%) had moderate disease, 11 (8.5%) had a severe disease, and 9 (6.9%) had a critical presentation with infants below 6 months having significantly increased risk of critical disease severity (OR 5.6, 95% CI 1.3 to 29.1). Seventy-five (57.7%) children were hospitalized, 15 (11.5%) needed some respiratory support, and nine (6.9%) were treated in an intensive care unit. All recovered.Conclusion:This descriptive case series of children with COVID-19, mostly encompassing of cases enrolled at hospital level, suggest that COVID-19 may have a non-negligible rate of severe presentations in selected pediatric populations with a relatively high rates of comorbidities. More studies are needed to further understand the presentation and outcomes of children with COVID-19 in children with special needs. What is Known:• There is limited evidence on the clinical presentation and outcomes of children with COVID-19 in Europe, and almost no evidence on characteristics and risk factors of severe cases. What is New:• Among a case series of 130 children, mostly diagnosed at hospital level, and with a relatively high rate (26.2%) of comorbidities, about three-quarter had an asymptomatic or mild disease.• However, 57.7% were hospitalized, 11.5% needed some respiratory support, and 6.9% were treated in an intensive care unit.
- Published
- 2020