42 results on '"Marian Devonec"'
Search Results
2. Technique of Injection of Hyaluronic Acid as a Prostatic Spacer and Fiducials Before Hypofractionated External Beam Radiotherapy for Prostate Cancer
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A. Faix, O. Chapet, Xavier Rebillard, Corina Udrescu, Philippe Paparel, Romain Boissier, Alain Ruffion, Jean-Etienne Terrier, Marian Devonec, David Azria, Chirurgie urologique et transplantation rénale [Hôpital de la Conception - APHM], Aix Marseille Université (AMU)-Assistance Publique - Hôpitaux de Marseille (APHM)-Hôpital de la Conception [CHU - APHM] (LA CONCEPTION), Vascular research center of Marseille (VRCM), Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut des Biomolécules Max Mousseron [Pôle Chimie Balard] (IBMM), Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)-Université de Montpellier (UM)-Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM), Service d'urologie, Centre Hospitalier Lyon Sud [CHU - HCL] (CHLS), Hospices Civils de Lyon (HCL)-Hospices Civils de Lyon (HCL), Ciblage thérapeutique en Oncologie (EA3738), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon, Institut de Recherche en Cancérologie de Montpellier (IRCM - U1194 Inserm - UM), CRLCC Val d'Aurelle - Paul Lamarque-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM), Hospices Civils de Lyon (HCL), Service d'urologie [Centre Hospitalier Lyon Sud - HCL], Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM)-Institut de Chimie du CNRS (INC)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), and Clinique Beau Soleil [Montpellier]
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Male ,medicine.medical_specialty ,Urology ,medicine.medical_treatment ,[SDV]Life Sciences [q-bio] ,Rectum ,Endosonography ,Injections ,030218 nuclear medicine & medical imaging ,03 medical and health sciences ,Prostate cancer ,0302 clinical medicine ,Fiducial Markers ,Prostate ,medicine ,Humans ,Local anesthesia ,External beam radiotherapy ,Hyaluronic Acid ,Radiation Injuries ,ComputingMilieux_MISCELLANEOUS ,Aged ,Viscosupplements ,medicine.diagnostic_test ,business.industry ,Dose fractionation ,Prostatic Neoplasms ,Magnetic resonance imaging ,Middle Aged ,medicine.disease ,Magnetic Resonance Imaging ,3. Good health ,Surgery ,Radiation therapy ,Treatment Outcome ,medicine.anatomical_structure ,030220 oncology & carcinogenesis ,Dose Fractionation, Radiation ,Radiotherapy, Intensity-Modulated ,Nuclear medicine ,business ,Radiotherapy, Image-Guided - Abstract
Objective To describe a technique combining the implantation of fiducials and a prostatic spacer (hyaluronic acid [HA]) to decrease the rectal toxicity after an image-guided external beam radiotherapy (EBRT) with hypofractionation for prostate cancer and to assess the tolerance and the learning curve of the procedure. Materials and Methods Thirty patients with prostate cancer at low or intermediate risk were included in a phase II trial: image-guided EBRT of 62 Gy in 20 fractions of 3.1 Gy with intensity-modulated radiotherapy. A transrectal implantation of 3 fiducials and transperineal injection of 10 cc of HA (NASHA gel spacer, Q-Med AB, Uppsala, Sweden) between the rectum and the prostate was performed by 1 operator. The thickness of HA was measured at 10 points on magnetic resonance imaging to establish a quality score of the injection (maximum score = 10) and determine the learning curve of the procedure. Results The quality score increased from patients 1-10, 11-20, to 21-30 with respective median scores: 7 [2-10], 5 [4-7], and 8 [3-10]. The average thicknesses of HA between the base, middle part, and apex of the prostate and the rectum were the following: 15.1 mm [6.4-29], 9.8 mm [5-21.2], and 9.9 mm [3.2-21.5]. The injection of the HA induced a median pain score of 4 [1-8] and no residual pain at mid-long term. Conclusion Creating an interface between the rectum and the prostate and the implantation of fiducials were feasible under local anesthesia with a short learning curve and could become a standard procedure before a hypofractionated EBRT for prostate cancer.
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- 2017
3. Transurethral plasma vaporization of the prostate: 3-month functional outcome and complications
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Gilles Pasticier, Grégoire Robert, Charles Ballereau, O. Dumonceau, Bertrand Lukacs, Nicolas Barry Delongchamps, Olivier Haillot, Alexandre de la Taille, Aurélien Descazeaud, Marian Devonec, Christian Saussine, Abdel-Rahmène Azzouzi, Marc Fourmarier, and François Kleinklauss
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medicine.medical_specialty ,Blood transfusion ,business.industry ,Urology ,medicine.medical_treatment ,law.invention ,Surgery ,Catheter ,medicine.anatomical_structure ,Randomized controlled trial ,Prostate ,law ,Cohort ,medicine ,International Prostate Symptom Score ,business ,Prospective cohort study ,Transurethral resection of the prostate - Abstract
Study Type – Therapy (multi-centre cohort) Level of Evidence 2b OBJECTIVE To evaluate the early functional outcomes of transurethral plasma vaporization of the prostate (TUVis) in a multicentre study. PATIENTS AND METHODS A prospective multicentre observational study was conducted in eight urology departments. The inclusion criterion was benign prostatic hyperplasia (BPH) requiring surgical treatment. Patients on anti-coagulant therapy were not excluded. The TUVis procedure was performed according to a classic transurethral resection of the prostate (TURP) scheme following the manufacturer’s recommendations. We evaluated subjective functional outcome using self-questionnaires (International Prostate Symptom Score [IPSS] and five-item International Index of Erectile Function [IIEF-5]) and objective criteria (prostate volume, prostate-specific antigen [PSA], uroflowmetry, post residual volume) at baseline and at 1- and 3-month follow-ups. All types of complications were systematically recorded. RESULTS Despite 52% of patients receiving anticoagulant therapy before surgery, we reported only 3% with haemorrhagic complications, no blood transfusion, a mean catheterization time of 44 h and a mean postoperative stay of 2.9 nights. No significant change in irrigation time, catheter time or hospital stay was observed in patients with or without anticoagulant therapy. The IPSS and bother scores significantly decreased after the 3-month follow-up (57% and 59%, respectively), but the average remaining prostate volume was 29 cc and the tissue ablation rate was only 0.5 cc/min. Three major complications occurred, consisting of two urinary fistulas and one partial bladder coagulation. CONCLUSIONS The TUVis procedure has a proven fast postoperative recovery time, good short-term functional outcome and good haemostatic efficiency. However, the tissue ablation rate was lower than expected and we encountered three major complications, the mechanisms of which remain unclear. Considering the high energy level required to create the plasma effect, the generator, cable and resectoscope must be carefully checked before each procedure.
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- 2010
4. Blood Loss During Transurethral Resection of the Prostate as Measured by the Chromium-51 Method
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Nicolas Barry Delongchamps, Charles Ballereau, Alexandre de la Taille, Aurélien Descazeaud, F. Bruyère, Grégoire Robert, J. Berger, Abdel Rahmene Azzousi, Christian Saussine, Marc Fourmarier, Olivier Haillot, Marian Devonec, and O. Dumonceau
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Male ,Nephrology ,medicine.medical_specialty ,Erythrocytes ,Urology ,medicine.medical_treatment ,Blood Loss, Surgical ,Hematocrit ,Preoperative care ,Prostate ,Internal medicine ,Preoperative Care ,medicine ,Humans ,Aged ,Transurethral resection of the prostate ,Univariate analysis ,medicine.diagnostic_test ,business.industry ,Transurethral Resection of Prostate ,Hyperplasia ,medicine.disease ,Chromium Radioisotopes ,Surgery ,medicine.anatomical_structure ,Isotope Labeling ,Hemoglobin ,business - Abstract
To evaluate blood loss during transurethral resection of the prostate (TURP), and its predictive factors, using the chromium 51 (51Cr) labeling method.From January to June 2008, 41 patients who underwent TURP for symptomatic benign prostatic hyperplasia (BPH) at four French urology centers were included in the analysis. Red cells volume was measured by the 51Cr method 1 day before TURP, and on postoperative day 3. Overall blood loss was estimated by multiplication of red cells volume loss and preoperative venous hematocrit value.Mean preoperative red cells volume was 1997 mL. Mean loss of red cells volume was 209 ml, which corresponds to an estimated blood loss of 507 mL. Mean delta of hematocrit and hemoglobin were 1.4% and 0.71 g/dL, respectively. In univariate analysis, prostate volume, weight of resected tissue, preoperative red cells volume, and resection time were significantly and directly associated with loss of red cells volume (P = 0.038, P = 0.004, P = 0.002, and P = 0.039, respectively). Bipolar and monopolar TURP did not lead to significant difference of red cells loss. In multivariate analysis, both preoperative red cells volume and weight of resected tissue were independent predictors of red cells loss (P = 0.017 and P = 0.048 respectively).We present the first study to measure blood loss secondary to TURP using the 51Cr method. This technique allowed evaluating blood loss not only during the surgical procedure but also during the postoperative period. We learned from this study that, on average, blood loss from the procedure until postoperative day 3 was more than 500 mL, which is larger than previously reported amounts as measured by other methods. Because significant blood loss might occur during the postoperative period, the 51Cr method should be used to measure blood loss when evaluating new emerging techniques to manage BPH.
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- 2010
5. Urinary Prostate Cancer 3 Test: Toward the Age of Reason?
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J. André, Virginie Vlaeminck-Guillem, Alain Ruffion, Philippe Paparel, and Marian Devonec
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Male ,Nephrology ,PCA3 ,Oncology ,medicine.medical_specialty ,Pathology ,medicine.diagnostic_test ,business.industry ,Urology ,Urinary system ,Prostatic Neoplasms ,Reproducibility of Results ,Cancer ,medicine.disease ,Prostate cancer ,medicine.anatomical_structure ,Antigen ,Antigens, Neoplasm ,Prostate ,Internal medicine ,Biopsy ,medicine ,Humans ,RNA ,business - Abstract
The prostate cancer 3 (PCA3) gene was discovered in 1999, on the basis of differential expression between cancer and noncancerous prostate tissue. Including the first study published in 2003, 11 clinical studies have evaluated its utility for the diagnosis of prostate cancer by measuring the number of PCA3 RNA copies in urine enriched with prostate cells. Although the sensitivity of the PCA3 test was less than that of serum prostate-specific antigen (PSA), its specificity appeared to be much better, particularly in patients with a previous negative biopsy. Recent studies also have suggested that this test could be used to predict cancer prognosis.
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- 2010
6. Contents Vol. 84, 2010
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F. Marchese, J. Zanow, Yoshihisa Kawai, L. Macchione, Vanessa Sandim, J. Masood, Jocelyn M. Rieder, H. Wunderlich, Marc Fourmarier, Kohsuke Sasaki, Rany Shamloul, Tomoyuki Murakami, Nicolas Barry Delongchamps, Yoshiaki Yamamoto, Stephan A. Krueger, O.W. Hakenberg, Christian Schwentner, S. Fuessel, Kristina Hotakainen, I. Ioannou, Takahiko Hara, Jörg Hennenlotter, N. Kroeger, A. Di Benedetto, F. Fraggetta, Kazuhiro Nagao, Gilda Alves, Christian Saussine, Karen Stern, Klaus G. Fink, C. Magno, Charles Ballereau, Claudius Fuellhase, Pascual Chuan-Nuez, Johan Lundin, T. Briggs, José M. Martínez-Jabaloyas, Ursula Kuehs, M. Madonia, Bertrand Lukacs, Donald C. McMillan, Taku Misumi, G. Grasso, Sherif R. Aboseif, John Brusky, Hideyasu Matsuyama, Rashad Mammadov, Harald Trummer, Alexander Winter, Erkan Kismali, Salih Sanlioglu, Aurélien Descazeaud, Viet Tran, Harri Visapää, Omer Kutlu, Adnan Şimşir, I. Petersen, N. Buchholz, Roman Szlauer, Friedhelm Wawroschek, Olivier Haillot, G. Candiano, Badereddin Mohamad Al-Ali, G. Shaw, Francois Desgrandchamps, Denise A. Pereira, Shigeru Sakano, Hideaki Ito, Ahter Dilsad Sanlioglu, Jens Uphoff, Martti Ala-Opas, I. Pirozhok, Luis Arenas, T. Castelli, M.P. Wirth, Arnulf Stenzl, Kazuhiko Nakano, J. Gelister, T. Steiner, Gurhan Gunaydin, F. Aragona, G. Romano, Alexandre de la Taille, Antonio A. Ornellas, Heinz-Peter Schlemmer, Daniela Colleselli, Kazumi Suzuki, Levent A. Guner, Tahir Qayyum, A. Meye, Richard Zigeuner, Satoshi Eguchi, Marian Devonec, Ismail Turker Koksal, David Schilling, Ljiljana Paras, G. Morgia, A. Galia, Rafael Villamón-Fort, Ulrich H. Vogel, P. Pepe, Katsusuke Naito, Cag Cal, M. Gajda, Manuel Gil-Salom, Karl Pummer, Rolf-Peter Henke, A. Papatsoris, U. Settmacher, A. Galì, G. Mucciardi, Tatsuo Morita, Grégoire Robert, Olivier Dumonceau, J. Fichtner, G. Bonvissuto, Ulf-Håkan Stenman, Matthias P. Lichy, Seiji Yano, P A McArdle, and Rahmene Azzouzi
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Traditional medicine ,business.industry ,Urology ,Medicine ,business - Published
- 2010
7. Intérêts des antidiurétiques, des anticholinergiques, des anti-inflammatoires et de la toxine botulinique pour le traitement des troubles mictionnels liés à I’HBP (Forum CTMH-AFU 2005)
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Abdel-Rahmène Azzouzi, Christian Saussine, Charles Ballereau, Marc Fourmarier, François Desgrandchamps, Alexandre de la Taille, Bertrand Lukacs, Olivier Haillot, and Marian Devonec
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Gynecology ,medicine.medical_specialty ,business.industry ,Urology ,medicine ,Prostate disease ,business - Abstract
Resume Recemment, de nouvelles voies therapeutiques ont ete explorees afin d’ameliorer les troubles mictionnels des patients presentant des troubles urinaires du bas appareil lies a une hyperplasie benigne de la prostate. L’objectif de cet article est de realiser une mise au point sur ces traitements : anti-inflammatoire, antidiuretique, anticholinergique et toxine botulinique. Les anticholinergiques, associes au risque de retention urinaire se revelent efficaces pour les troubles irritatifs en association a un alpha-bloquant. Les antidiuretiques peuvent etre proposes chez les patients de moins de 65 ans presentant une polyurie confirmee par un calendrier mictionnel, invalidante, liee a une HBP et refractaire au traitement classique de I’HBP. L’interaction entre l’inflammation et HBP n’est pas encore clarifiee. Les anti-inflammatoires semblant ameliorer les symptomes trouveraient peut etre une place dans un traitement ponctuel de 1’HBP car leur utilisation au long cours n’est pas recommandee. Les inhibiteurs de cox-2 ont ete retires du marche. Enfm, la toxine botulinique pourrait avoir une place dans le traitement des troubles lies a I’HBP si les etudes cliniques confirment les resultats prometteurs recemment publies. Ces nouvelles approches seront probablement a integrer dans les recommandations et les arbres decisionnels du traitement des troubles mictionnels lies a I’HBP.
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- 2007
8. Intérêt des marqueurs urinaires dans le diagnostic et le suivi des tumeurs urothéliales de vessie
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J. André, Paul Perrin, Jean-Louis Campos-Fernandes, Marian Devonec, Alain Ruffion, and Françoise Descotes
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Gynecology ,medicine.medical_specialty ,business.industry ,Urology ,medicine ,business - Abstract
Resume Les tumeurs urotheliales de vessie necessitent une surveillance reguliere : la cystoscopie associee a la cytology urinaire en sont les examens de reference. Recemment, plusieurs nouveaux marqueurs valides ou en cours d’evaluation ont ete proposes afin de remplacer la cytologie et potentiellement de reduire, voire de remplacer les cystoscopies inutiles. Le liquide biologique etudie pour tous ces marqueurs est le meme que la cytologie urinaire, c’est a dire l’urine. Dans ce travail, nous avons fait le point sur les resultats des travaux recents concernant ces nouveaux marqueurs urinaires. Les resultats de ces marqueurs montrent une meilleure sensibilite globale que la cytologie urinaire, mais souvent une specificite moins bonne. Dans la majorite des cas, ces tests sont realises lors du suivi des patients (NMP22, BTA, CYFRA 21-1 …), mais ne remplacent pas la cystoscopie, du fait d’un nombre eleve de faux-positifs. D’autres techniques, tels que la FISH, le uCyt+ ou les microsatellites semblent etre des tests plus prometteurs, notamment dans le diagnostic des tumeurs de bas grade. Dans la pratique, la solution viendra peut-etre de l’association de plusieurs marqueurs pour ameliorer encore la sensibilite, et diminuer le taux de faux-positifs responsables des cystoscopies inutiles.
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- 2007
9. Subject Index Vol. 84, 2010
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G. Bonvissuto, Rahmene Azzouzi, G. Mucciardi, Tatsuo Morita, Adnan Şimşir, Friedhelm Wawroschek, Olivier Haillot, F. Marchese, Kohsuke Sasaki, Claudius Fuellhase, Pascual Chuan-Nuez, Francois Desgrandchamps, Denise A. Pereira, Olivier Dumonceau, Ursula Kuehs, Omer Kutlu, Tomoyuki Murakami, Seiji Yano, P A McArdle, Shigeru Sakano, Kristina Hotakainen, I. Ioannou, Takahiko Hara, Kazuhiro Nagao, Gilda Alves, J. Fichtner, G. Grasso, Roman Szlauer, I. Pirozhok, Luis Arenas, Marc Fourmarier, Aurélien Descazeaud, A. Papatsoris, Viet Tran, G. Shaw, Stephan A. Krueger, Martti Ala-Opas, S. Fuessel, Donald C. McMillan, Christian Schwentner, Satoshi Eguchi, F. Aragona, Antonio A. Ornellas, N. Buchholz, Klaus G. Fink, Kazumi Suzuki, J. Zanow, Ismail Turker Koksal, J. Gelister, Yoshihisa Kawai, I. Petersen, T. Castelli, Levent A. Guner, Kazuhiko Nakano, T. Steiner, Vanessa Sandim, Richard Zigeuner, Taku Misumi, L. Macchione, Marian Devonec, Johan Lundin, Gurhan Gunaydin, P. Pepe, Tahir Qayyum, A. Meye, John Brusky, Katsusuke Naito, Rany Shamloul, N. Kroeger, Rashad Mammadov, Alexandre de la Taille, A. Di Benedetto, Nicolas Barry Delongchamps, Heinz-Peter Schlemmer, Yoshiaki Yamamoto, Alexander Winter, Cag Cal, Salih Sanlioglu, M. Gajda, José M. Martínez-Jabaloyas, Daniela Colleselli, Rafael Villamón-Fort, Ulrich H. Vogel, Ahter Dilsad Sanlioglu, Jens Uphoff, Christian Saussine, M. Madonia, Charles Ballereau, Bertrand Lukacs, David Schilling, Ljiljana Paras, G. Morgia, G. Candiano, Jörg Hennenlotter, A. Galia, Arnulf Stenzl, Hideyasu Matsuyama, Erkan Kismali, F. Fraggetta, Jocelyn M. Rieder, M.P. Wirth, H. Wunderlich, Harri Visapää, O.W. Hakenberg, Karen Stern, T. Briggs, U. Settmacher, A. Galì, Grégoire Robert, G. Romano, Ulf-Håkan Stenman, Matthias P. Lichy, J. Masood, Karl Pummer, Rolf-Peter Henke, Manuel Gil-Salom, C. Magno, Sherif R. Aboseif, Harald Trummer, Badereddin Mohamad Al-Ali, and Hideaki Ito
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Gerontology ,Index (economics) ,business.industry ,Urology ,Medicine ,Subject (documents) ,business - Published
- 2010
10. Néphrectomie partielle du transplant rénal : étude multicentrique
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R. Codas, Georges Karam, François Kleinclauss, L. Viart, Xavier Tillou, L. Salomon, A. Erauso, Gregory Verhoest, Nicolas Terrier, C. Sénéchal, Fabrice Dugardin, Damien Chambade, F. Salusto, Marian Devonec, K. Guleryuz, Jacques Hubert, Henri Bensadoun, Arnaud Doerfler, Rodolphe Thuret, and M.O. Timsit
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Gynecology ,medicine.medical_specialty ,business.industry ,Urology ,medicine ,business - Abstract
Objectifs Etudier les resultats des nephrectomies partielles du greffon renale (NPGR) pour tumeur renale de novo. Methodes Etude retrospective nationale, multicentrique. Les donnees ont ete recueillies dans 32 centres de transplantation francais. De janvier 1988 a avril 2012, les patients traites pour tumeur renale d’un greffon fonctionnel ont ete inclus. Soixante-dix -neuf tumeurs de novo du greffon renal ont ete diagnostiquees. Resultats 43 patients ont eu une NPGR. Le temps moyen entre la transplantation et le diagnostic de la tumeur etait de 142,6 mois (12,2 a 300). Quinze tumeurs etaient des carcinomes a cellules claires (34,9 %), vingt-cinq (58,1 %) des carcinomes papillaires. Respectivement 10 (24,4 %), 24 (58,3 %) et 8 (19,5 %) tumeurs etaient Fuhrman grade 1, 2 et 3. Neuf patients ont eu des complications post-operatoires (20,9 %) dont 4 necessitant une intervention chirurgicale (Clavien IIIb) et sans retour en dialyse dans les suites de la NPGR. Toutes les marges chirurgicales etaient negatives avec un diametre moyen de 26 mm. La duree moyenne de suivi etait de 29,6 mois (0,65 - 100,6) et 41 patients avaient un greffon renal fonctionnel, sans dialyse et sans complications a long terme. Conclusion La NPGR est une indication sure et appropriee pour toutes les petites tumeurs du rein transplante avec des resultats fonctionnels et oncologiques tres bons a long terme evitant aux patients un retour en dialyse.
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- 2014
11. PCA3 and PCA3-Based Nomograms Improve Diagnostic Accuracy in Patients Undergoing First Prostate Biopsy
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Marian Devonec, Claire Rodriguez-Lafrasse, Alain Ruffion, Paul Perrin, Virginie Vlaeminck-Guillem, Myriam Decaussin-Petrucci, Philippe Paparel, and D. Champetier
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Male ,PCA3 ,medicine.medical_specialty ,Prostate biopsy ,Biopsy ,Urology ,urologic and male genital diseases ,Article ,Catalysis ,Inorganic Chemistry ,nomogram ,lcsh:Chemistry ,Prostate cancer ,Prostate ,Humans ,Medicine ,Prostate Cancer Prevention Trial ,urine biomarker ,initial prostate biopsy ,prostate cancer ,prostate cancer antigen 3 ,Prospective Studies ,Physical and Theoretical Chemistry ,Molecular Biology ,lcsh:QH301-705.5 ,Spectroscopy ,Aged ,medicine.diagnostic_test ,business.industry ,Organic Chemistry ,Prostatic Neoplasms ,General Medicine ,Middle Aged ,Prostate-Specific Antigen ,Nomogram ,medicine.disease ,Computer Science Applications ,Prostate-specific antigen ,medicine.anatomical_structure ,lcsh:Biology (General) ,lcsh:QD1-999 ,business - Abstract
While now recognized as an aid to predict repeat prostate biopsy outcome, the urinary PCA3 (prostate cancer gene 3) test has also been recently advocated to predict initial biopsy results. The objective is to evaluate the performance of the PCA3 test in predicting results of initial prostate biopsies and to determine whether its incorporation into specific nomograms reinforces its diagnostic value. A prospective study included 601 consecutive patients addressed for initial prostate biopsy. The PCA3 test was performed before ≥12-core initial prostate biopsy, along with standard risk factor assessment. Diagnostic performance of the PCA3 test was evaluated. The three available nomograms (Hansen’s and Chun’s nomograms, as well as the updated Prostate Cancer Prevention Trial risk calculator; PCPT) were applied to the cohort, and their predictive accuracies were assessed in terms of biopsy outcome: the presence of any prostate cancer (PCa) and high-grade prostate cancer (HGPCa). The PCA3 score provided significant predictive accuracy. While the PCPT risk calculator appeared less accurate; both Chun’s and Hansen’s nomograms provided good calibration and high net benefit on decision curve analyses. When applying nomogram-derived PCa probability thresholds ≤30%, ≤6% of HGPCa would have been missed, while avoiding up to 48% of unnecessary biopsies. The urinary PCA3 test and PCA3-incorporating nomograms can be considered as reliable tools to aid in the initial biopsy decision.
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- 2013
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12. Dosimetric implications of an injection of hyaluronic acid for preserving the rectal wall in prostate stereotactic body radiation therapy
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Patrice Jalade, Marie-Pierre Sotton, Pascal Fenoglietto, Alain Ruffion, Marc Colombel, Ronan Tanguy, Olivier Chapet, Corina Udrescu, Marian Devonec, and David Azria
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Male ,Cancer Research ,Hypofractionated Radiation Therapy ,medicine.medical_treatment ,Rectum ,Phases of clinical research ,Radiosurgery ,chemistry.chemical_compound ,Prostate ,Hyaluronic acid ,Medicine ,Humans ,Radiology, Nuclear Medicine and imaging ,Hyaluronic Acid ,Radiation Injuries ,Radiation ,Viscosupplements ,business.industry ,Radiotherapy Planning, Computer-Assisted ,Dose fractionation ,Isocenter ,Prostatic Neoplasms ,Tumor Burden ,Radiation therapy ,medicine.anatomical_structure ,Oncology ,chemistry ,Dose Fractionation, Radiation ,Radiotherapy, Intensity-Modulated ,business ,Nuclear medicine ,Tomography, X-Ray Computed ,Organ Sparing Treatments - Abstract
Purpose This study assessed the contribution of ahyaluronic acid (HA) injection between the rectum and the prostate to reducing the dose to the rectal wall in stereotactic body radiation therapy (SBRT). Methods and Materials As part of a phase 2 study of hypofractionated radiation therapy (62 Gy in 20 fractions), the patients received a transperineal injection of 10 cc HA between the rectum and the prostate. A dosimetric computed tomographic (CT) scan was systematically performed before (CT1) and after (CT2) the injection. Two 9-beam intensity modulated radiation therapy-SBRT plans were optimized for the first 10 patients on both CTs according to 2 dosage levels: 5 × 6.5 Gy (PlanA) and 5 × 8.5 Gy (PlanB). Rectal wall parameters were compared with a dose–volume histogram, and the prostate–rectum separation was measured at 7 levels of the prostate on the center line of the organ. Results For both plans, the average volume of the rectal wall receiving the 90% isodose line (V90%) was reduced up to 90% after injection. There was no significant difference ( P =.32) between doses received by the rectal wall on CT1 and CT2 at the base of the prostate. This variation became significant from the median plane to the apex of the prostate ( P =.002). No significant differences were found between PlanA without HA and PlanB with HA for each level of the prostate ( P =.77, at the isocenter of the prostate). Conclusions HA injection significantly reduced the dose to the rectal wall and allowed a dose escalation from 6.5 Gy to 8.5 Gy without increasing the dose to the rectum. A phase 2 study is under way in our department to assess the rate of acute and late rectal toxicities when SBRT (5 × 8.5 Gy) is combined with an injection of HA.
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- 2013
13. Down-regulation of DcR2 sensitizes androgen-dependent prostate cancer LNCaP cells to TRAIL-induced apoptosis
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Catherine Deschildre, David Vindrieux, Marian Devonec, Renée Grataroli, Sadok Yakoub, Jacqueline Chantepie, Marie Reveiller, Mohamed Benahmed, Alain Ruffion, Centre de Recherche en Cancérologie de Lyon (UNICANCER/CRCL), Centre Léon Bérard [Lyon]-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Department of Medicine and Pathology, NYU Langone Medical Center, Unité de Nutrition Humaine (UNH), Institut National de la Recherche Agronomique (INRA)-Université d'Auvergne - Clermont-Ferrand I (UdA)-Clermont Université, Immunité infection vaccination (I2V), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-IFR128-Institut National de la Santé et de la Recherche Médicale (INSERM), Service d'urologie [Centre Hospitalier Lyon Sud - HCL], Centre Hospitalier Lyon Sud [CHU - HCL] (CHLS), Hospices Civils de Lyon (HCL)-Hospices Civils de Lyon (HCL), Centre méditérannéen de médecine moléculaire (C3M), Université Nice Sophia Antipolis (1965 - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Institut National de la Santé et de la Recherche Médicale (INSERM), SFR Biosciences, École normale supérieure de Lyon (ENS de Lyon)-Université Claude Bernard Lyon 1 (UCBL), This work has been funded by INSERM Contract grant sponsor: Association pour la Recherche sur les Tumeurs de la Prostate (ARTP), Fondation pour la Recherche Médicale (FRM) and Association pour la Recherche contre le Cancer (ARC), fellowship to DV. Contract grant sponsor: Ligue Contre Le Cancer: Comité de l'Ardèche & Comité de la Drôme, to RG., Grataroli, Renee, Centre de Recherche en Cancérologie de Lyon (CRCL), Université de Lyon-Université de Lyon-Centre Léon Bérard [Lyon]-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Université Nice Sophia Antipolis (... - 2019) (UNS), Université Côte d'Azur (UCA)-Université Côte d'Azur (UCA)-Institut National de la Santé et de la Recherche Médicale (INSERM), École normale supérieure - Lyon (ENS Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM), Université d'Auvergne - Clermont-Ferrand I (UdA)-Clermont Université-Institut National de la Recherche Agronomique (INRA), and BMC, Ed.
- Subjects
Cancer Research ,medicine.medical_specialty ,Programmed cell death ,medicine.drug_class ,Receptor expression ,TRAIL ,Apoptosis ,[SDV.CAN]Life Sciences [q-bio]/Cancer ,urologic and male genital diseases ,lcsh:RC254-282 ,Androgen ,03 medical and health sciences ,Prostate cancer ,0302 clinical medicine ,tumeur ,[SDV.CAN] Life Sciences [q-bio]/Cancer ,Downregulation and upregulation ,Internal medicine ,LNCaP ,Genetics ,medicine ,trail ,dcr2 ,prostate cancer ,apoptosis ,androgen ,oncology ,lcsh:QH573-671 ,Receptor ,030304 developmental biology ,0303 health sciences ,business.industry ,lcsh:Cytology ,Prostate Cancer ,medicine.disease ,lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,cancer de la prostate ,Endocrinology ,Oncology ,030220 oncology & carcinogenesis ,Cancer research ,DcR2 ,Primary Research ,business - Abstract
Background Dysregulation of many apoptotic related genes and androgens are critical in the development, progression, and treatment of prostate cancer. The differential sensitivity of tumour cells to TRAIL-induced apoptosis can be mediated by the modulation of surface TRAIL receptor expression related to androgen concentration. Our previous results led to the hypothesis that downregulation of TRAIL-decoy receptor DcR2 expression following androgen deprivation would leave hormone sensitive normal prostate cells vulnerable to the cell death signal generated by TRAIL via its pro-apoptotic receptors. We tested this hypothesis under pathological conditions by exploring the regulation of TRAIL-induced apoptosis related to their death and decoy receptor expression, as also to hormonal concentrations in androgen-sensitive human prostate cancer, LNCaP, cells. Results In contrast to androgen-insensitive PC3 cells, decoy (DcR2) and death (DR5) receptor protein expression was correlated with hormone concentrations and TRAIL-induced apoptosis in LNCaP cells. Silencing of androgen-sensitive DcR2 protein expression by siRNA led to a significant increase in TRAIL-mediated apoptosis related to androgen concentration in LNCaP cells. Conclusions The data support the hypothesis that hormone modulation of DcR2 expression regulates TRAIL-induced apoptosis in LNCaP cells, giving insight into cell death induction in apoptosis-resistant hormone-sensitive tumour cells from prostate cancer. TRAIL action and DcR2 expression modulation are potentially of clinical value in advanced tumour treatment.
- Published
- 2011
14. Value of PCA3 urinary test for prostate biopsy decision: the Lyon-Sud University Hospital experience
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Paul Perrin, Claire Rodriguez-Lafrasse, Alain Ruffion, D. Champetier, Myriam Decaussin-Petrucci, Virginie Vlaeminck-Guillem, Jean-Louis Campos-Fernandes, Nicolas Gobeaux, Marian Devonec, Philippe Paparel, Karim Chikh, Institut National de la Recherche Agronomique (INRA), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon, and Centre Hospitalier Universitaire de Lyon
- Subjects
PCA3 ,Male ,EXPRESSION ,medicine.medical_specialty ,Prostate biopsy ,diagnosis ,Urinary system ,Biopsy ,[SDV]Life Sciences [q-bio] ,Decision Making ,ANTIGEN ,PSA ,Antigens, Neoplasm ,Medicine ,Humans ,ASSAY ,Prospective Studies ,RNA, Messenger ,Aged ,Gynecology ,Aged, 80 and over ,medicine.diagnostic_test ,business.industry ,REPEAT BIOPSY ,Prostate ,Prostatic Neoplasms ,MEN ,General Medicine ,Middle Aged ,PERFORMANCE ,University hospital ,prostate cancer ,CANCER ,urine ,ACTIVE SURVEILLANCE ,DD3(PCA3) ,TUMOR VOLUME ,business - Abstract
La faible specificite de la strategie diagnostique du cancer de la prostate (toucher rectal et dosage serique de l’antigene prostatique PSA) conduit a la realisation de nombreuses biopsies inutiles et au diagnostic de cancers indolents, sans potentialite evolutive. Un test urinaire (Progensa PCA3 ®, Gen-Probe) mesurant l’expression du gene PCA3, specifique des cellules cancereuses prostatiques, a recemment ete propose pour orienter les indications de re-biopsies. Le but de notre etude, prospective, etait d’evaluer l’interet diagnostique du score PCA3 dans le cancer de la prostate. Dans les urines de 245 patients adresses pour biopsie prostatique, l’expression du gene PCA3 a ete determinee par une technique d’amplification et de detection de l’ARN et rapportee a celle du PSA. Les patients avec echantillon informatif (98 %) ont ete classes selon la presence (n = 126) ou l’absence (n = 114) de cancer sur les biopsies. Le score PCA3 median etait plus eleve dans le groupe avec biopsies positives (p < 0,0001). L’aire sous la courbe ROC pour le PCA3 etait de 0,70 versus 0,53 pour le PSA total et 0,65 pour le rapport PSA libre/total. Au meilleur seuil de 38, le test PCA3 avait une sensibilite de 59 %, une specificite de 72 % (respectivement : 66 %, 32 % pour le PSA total au seuil de 4 ng/mL et 81 %, 28 % pour le rapport PSA libre/total au seuil de 25 %). Ces performances etaient maintenues chez les patients ayant un PSA dans la zone grise (4-10 ng/mL) ou ayant des antecedents de biopsies prostatiques. Notre etude confirme l’interet du test urinaire PCA3 dans l’aide a la decision de biopsies prostatiques.
- Published
- 2011
15. Studies of monoclonal antibody bl2-10d1 as a marker for the detection of the urothelial origin of tumors
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Jean-Claude Laurent, Dominique Dolbeau, Nicole Berger-Dutrieux, Alistair J. Cochran, Bernard Fontaniere, Marian Devonec, Marylène Guillaud, and Arlette Longin
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Male ,Cancer Research ,Pathology ,medicine.medical_specialty ,Metastasis ,Immunoenzyme Techniques ,Antigens, Neoplasm ,Prostate ,Biomarkers, Tumor ,medicine ,Carcinoma ,Humans ,Aged ,Carcinoma, Transitional Cell ,Bladder cancer ,Urinary bladder ,business.industry ,Antibodies, Monoclonal ,Prostatic Neoplasms ,Cancer ,Middle Aged ,Prostate-Specific Antigen ,medicine.disease ,medicine.anatomical_structure ,Transitional cell carcinoma ,Urinary Bladder Neoplasms ,Oncology ,Lymphatic Metastasis ,Adenocarcinoma ,Female ,business - Abstract
Background. In previous studies, the authors demonstrated the value of the monoclonal antibody (MoAb) BL2-10D1 in identifying malignant transitional cells. In this study, the authors evaluate the possible diagnostic value of a murine MoAb, BL2-10D1, raised against human bladder cancer in the determination of the urothelial origin of metastases in a series of 29 patients with metastatic bladder or prostatic carcinoma. Methods. Using an immunoperoxidase method, bl2-10d1 and anti-prostate-specific antigen (anti-psa) reactivity were studied, using histologic sections from 18 pelvic lymph nodes and 4 other anatomic sites invaded by transitional cell cancer, and from 7 pelvic lymph nodes containing prostatic cancer. Results. All lymph nodes containing metastases of transitional cell carcinoma were positive with BL2-10D1, whereas all metastases of prostatic cancer were negative; the four instances of distant urothelial metastases were positive with BL2-10D1 MoAb. Conversely, anti-PSA reacted only with prostatic metastases. Conclusion. Thus, MoAb BL2-10D1 and anti-PSA complement each other in the separation of cancers of prostatic and urothelial origin, and the BL2-10D1 MoAb has potential usefulness in differentiating between urothelial carcinoma and prostate adenocarcinoma. In patients with bladder tumors of uncertain origin, BL2-10D1 may be helpful in confirming that a tumor is a transitional cell carcinoma.
- Published
- 1993
16. Microwave thermotherapy in benign prostatic hypertrophy
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Simon Carter, Chris Ogden, and Marian Devonec
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medicine.medical_specialty ,business.industry ,Urology ,Medicine ,business ,Microwave thermotherapy ,Muscle hypertrophy - Published
- 1993
17. 2164 DE NOVO KIDNEY GRAFT TUMORS: RESULTS FROM A MULTICENTRIC RETROSPECTIVE NATIONAL STUDY
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Laurent Guy, Jean Michel Boutin, Bertrand Doré, Christophe Legendre, Xavier Tillou, Francois Kleinclaus, Maxime Audet, Thomas Perez, Jean Jacques Patard, Laurent Salomon, Georges Karam, Lionel Badet, Thierry Lebret, Benoit Barrou, Benoit Feuillu, Federico Sallusto, Julien Deturmeny, Jean Marie Ferriere, Ricardo Codas, Jean Philippe Rerolle, Pierre Bigot, Henri Bensadoun, Rodolphe Thuret, Marian Devonec, Jacques Dantal, Bernard Gattegno, Eric Lechevallier, Jacques Petit, Yann Neuzillet, Arnaud Doerfler, Damien Chambade, Nicolas Terrier, M. Gigante, Cédric Sénéchal, Gregory Verhoest, A. Erauso, Christiane Mousson, Emilie Berthoux, Fabrice Dugardin, and Ivan Bouzguenda
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Kidney ,medicine.medical_specialty ,business.industry ,Urology ,medicine.medical_treatment ,Incidence (epidemiology) ,medicine.disease ,Nephrectomy ,Surgery ,Transplantation ,medicine.anatomical_structure ,Cohort ,medicine ,Stage (cooking) ,business ,Kidney transplantation ,Dialysis - Abstract
De novo tumors in renal allografts are rare and their prevalence is underestimated. We therefore analyzed renal cell carcinomas arising in renal allografts through a retrospective French renal transplant cohort. We performed a retrospective, multicentric survey by sending questionnaires to all French kidney transplantation centers. All graft tumors diagnosed after transplantation were considered as de novo tumors. Thirty-two centers participated in this study. Seventy-nine tumors were identified among 41 806 recipients (Incidence 0.19%). Patients were 54 men and 25 women with a mean age of 47 years old at the time of diagnosis. Mean tumor size was 27.8 mm. Seventy-four (93.6%), 53 (67%) and 44 tumors (55.6%) were organ confined (T1-2), low grade (G1-2) and papillary carcinomas, respectively. Four patients died of renal cell carcinomas (5%). The mean time lapse between transplantation and RCC diagnosis was 131.7 months. Thirty-five patients underwent conservative surgery by partial nephrectomy (n = 35, 44.3%) or radiofrequency (n = 5; 6.3%). The estimated 5 years cancer specific survival rate was 94%. Most of these tumors were small and incidental. Most tumors were papillary carcinoma, low stage and low grade carcinomas. Conservative treatment has been preferred each time it was feasible in order to avoid a return to dialysis.
- Published
- 2010
18. Impact of lower urinary tract symptoms on discomfort in men aged between 50 and 80 years
- Author
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Bertrand Lukacs, Alexandre de la Taille, Grégoire Robert, Charles Ballereau, Aurélien Descazeaud, François Desgrandchamps, Rahmene Azzouzi, O. Dumonceau, Christian Saussine, Olivier Haillot, Marian Devonec, Marc Fourmarier, Nicolas Barry Delongchamps, Service d'urologie, andrologie et transplantation rénale, Université Bordeaux Segalen - Bordeaux 2-CHU Bordeaux [Bordeaux]-Groupe hospitalier Pellegrin, Institut Mondor de Recherche Biomédicale (IMRB), Institut National de la Santé et de la Recherche Médicale (INSERM)-IFR10-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), Service de Néphrologie, Dialyse, Transplantations [CHU Limoges], CHU Limoges, Centre Hospitalier Universitaire d'Angers (CHU Angers), PRES Université Nantes Angers Le Mans (UNAM), CHU Strasbourg, Centre Hospitalier Régional Universitaire de Tours (CHRU Tours), Fondation Hôpital Saint Joseph, Clinique la Louvière, Centre Hospitalier d'Aix en Provence [Aix-en-Provence] (CHIAP ), Centre Hospitalier Lyon Sud [CHU - HCL] (CHLS), Hospices Civils de Lyon (HCL), Hôpital Cochin [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), CHU Tenon [AP-HP], Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Hôpital Saint-Louis, Université Paris Diderot - Paris 7 (UPD7)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), INSERM U955, équipe 7, Hôpital Henri Mondor, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Henri Mondor-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Henri Mondor-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12)-Institut Mondor de Recherche Biomédicale (IMRB), Institut National de la Santé et de la Recherche Médicale (INSERM)-IFR10-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12)-Institut National de la Santé et de la Recherche Médicale (INSERM)-IFR10-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Diderot - Paris 7 (UPD7), Université Bordeaux Segalen - Bordeaux 2 - CHU Bordeaux [Bordeaux] - Groupe hospitalier Pellegrin, Institut National de la Santé et de la Recherche Médicale (INSERM) - IFR10 - Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), Service de Néphrologie, Hémodialyse, Transplantations, PRES Université Nantes Angers Le Mans [UNAM], Centre Hospitalier Régional Universitaire de Tours, CHRU Tours, CH du Pays d'Aix, Centre Hospitalier du Pays d'Aix, Hospices Civils de Lyon / Centre hospitalier Lyon Sud (HCL), Hospices Civils de Lyon, CHU Cochin [APHP], CHU Tenon [APHP], Assistance publique - Hôpitaux de Paris (AP-HP) - Université Paris Diderot - Paris 7 (UP7), Assistance publique - Hôpitaux de Paris (AP-HP) - Hôpital Henri Mondor - Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12) - Assistance publique - Hôpitaux de Paris (AP-HP) - Hôpital Henri Mondor - Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12) - Institut Mondor de Recherche Biomédicale (IMRB), Institut National de la Santé et de la Recherche Médicale (INSERM) - IFR10 - Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12) - Institut National de la Santé et de la Recherche Médicale (INSERM) - IFR10, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), and Guellaen, Georges
- Subjects
Male ,medicine.medical_specialty ,Pediatrics ,Urology ,Population ,030232 urology & nephrology ,MEDLINE ,Prostatic Hyperplasia ,urologic and male genital diseases ,03 medical and health sciences ,0302 clinical medicine ,Age Distribution ,Quality of life ,Lower urinary tract symptoms ,Surveys and Questionnaires ,Epidemiology ,medicine ,[SDV.BBM] Life Sciences [q-bio]/Biochemistry, Molecular Biology ,Prevalence ,Humans ,[SDV.BBM]Life Sciences [q-bio]/Biochemistry, Molecular Biology ,education ,Aged ,Gynecology ,Aged, 80 and over ,education.field_of_study ,business.industry ,Age Factors ,Middle Aged ,medicine.disease ,Urination Disorders ,Health Surveys ,3. Good health ,030220 oncology & carcinogenesis ,Quality of Life ,Age distribution ,France ,business - Abstract
Background/Aims: There are only a few surveys on the prevalence of lower urinary tract symptoms (LUTS) among the general population. The aim of this survey was to assess the prevalence of LUTS and their impact on discomfort in men. Methods: A questionnaire was mailed to 3,877 men aged 50–80 years, which included questions on their medical history, demographic and sociological status, and also the International Prostate Symptom Score (IPSS) with additional questions on discomfort related to urinary symptoms. Results: The response rate was 81.5%. Prevalence of mild and severe IPSS was 89.2%. Specific bother for each urinary symptom depended on symptom frequency: urgency, frequency, weak stream, nocturia, incomplete emptying, intermittency and straining 1 time out of 5 were responsible for discomfort in respectively 4.9, 6.1, 7.1, 7.5, 8.7 and 9.9%; the same symptoms more than half of the time were responsible for discomfort in respectively 32.8, 38, 45.3, 45.6, 53.2 and 58.7%. Urgency was much more deeply implicated in discomfort than frequency of nocturia. Conclusions: Urinary symptoms in men are very common. Nocturia is the most frequent but has a low impact on discomfort. Urgency has a higher impact on discomfort and should therefore be considered in treatment decision-making.
- Published
- 2009
19. Urinary PCA3 score predicts prostate cancer multifocality
- Author
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Marc Colombel, Virginie Vlaeminck-Guillem, Claire Rodriguez-Lafrasse, Myriam Decaussin-Petrucci, Alain Ruffion, and Marian Devonec
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PCA3 ,Male ,medicine.medical_specialty ,Urology ,medicine.medical_treatment ,Prostate cancer ,Prostate ,Antigens, Neoplasm ,Predictive Value of Tests ,Biopsy ,medicine ,Humans ,Neoplasm Invasiveness ,Stage (cooking) ,medicine.diagnostic_test ,Prostatectomy ,business.industry ,Cancer ,Prostatic Neoplasms ,Organ Size ,Middle Aged ,medicine.disease ,Prostate-specific antigen ,medicine.anatomical_structure ,business - Abstract
The urinary PCA3 gene test has proved helpful for deciding whether to (re)biopsy to diagnose prostate cancer. We searched for pathological features that influence the shedding of PCA3 producing prostate cancer cells in urine after digital rectal examination.Included in our study were 102 patients with an informative PCA3 score on the Progensa® PCA3 assay who underwent radical prostatectomy. Correlations were evaluated between PCA3 score and histopathological factors on prostatectomy, including tumor site in the prostate and the number of cancer foci.PCA3 score significantly correlated with total tumor volume in prostatectomy specimens (p0.001) but not with prostatectomy Gleason score or pathological stage. PCA3 score positively correlated with apical and basal invasion, and with bilaterality and multifocality. On multivariate analysis multifocality was an independent factor influencing PCA3 score (p = 0.012).Site in the prostate gland and the number of cancer foci may explain the observed PCA3 score variation in patients operated on for prostate cancer. The PCA3 test could be helpful in preoperatively selecting patients with unifocal and unilateral cancer who could benefit from active surveillance or focal therapy.
- Published
- 2009
20. Transurethral Microwave Heating of the Prostate—Or from Hyperthermia to Thermotherapy
- Author
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Marian Devonec, N. Berger, and P. Perrin
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Hyperthermia ,medicine.medical_specialty ,Adenoma ,Transurethral microwave thermotherapy ,business.industry ,Urology ,medicine.medical_treatment ,Hyperplasia ,medicine.disease ,Surgery ,Urethra ,medicine.anatomical_structure ,Prostate ,Microwave heating ,medicine ,business ,Microwave thermotherapy - Abstract
The authors studied microwave delivery by a flexible applicator providing simultaneous cooling for anesthesiafree outpatient single session treatment of benign prostatic hyperplasia (BPH) following preclinical trials in dogs and humans. The goal of transurethral microwave thermotherapy (TUMT) was to raise the temperature within the prostate to more than 45°C while maintaining the urethral temperature below 45°C. Histologically, the urethral mucosa and periurethral tissues were well preserved. There was a sharp transition (1-2 mm) to the microwave-treated area, where the normal cellular arrangement disappeared and small blood vessels were thrombosed. Smooth-muscle cells were seen to be more heat sensitive than glandular tissue. In 37 patients with BPH, the new device (Prostatron) produced significant improvements in the symptom score peak/low and post residual volume at 3 months. Seven patients required an indwelling catheter for 1 week after treatment, but four then voided satisfactorily. No infections oc...
- Published
- 1991
21. Advantages of prostate-specific antigen (PSA) clearance model over simple PSA half-life computation to describe PSA decrease after prostate adenomectomy
- Author
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Paul Perrin, Brigitte Tranchand, Emilie Henin, Gilles Freyer, Cécile Fournel, Benjamin Ribba, Michel Tod, Philippe Paparel, Claire Falandry, Pascal Girard, Marian Devonec, Alain Ruffion, Benoit You, Service d'Oncologie Médicale [Centre hospitalier Lyon Sud - HCL], Centre Hospitalier Lyon Sud [CHU - HCL] (CHLS), Hospices Civils de Lyon (HCL)-Hospices Civils de Lyon (HCL), Service d'urologie [Centre Hospitalier Lyon Sud - HCL], Centre Léon Bérard [Lyon], Université de Lyon, Numerical Medicine (NUMED), Unité de Mathématiques Pures et Appliquées (UMPA-ENSL), École normale supérieure de Lyon (ENS de Lyon)-Centre National de la Recherche Scientifique (CNRS)-École normale supérieure de Lyon (ENS de Lyon)-Centre National de la Recherche Scientifique (CNRS)-Inria Grenoble - Rhône-Alpes, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria), Service de Maladies Infectieuses et Tropicales [Hôpital de la Croix-Rousse - HCL], Hôpital de la Croix-Rousse [CHU - HCL], Centre de recherche cerveau et cognition (CERCO), Institut des sciences du cerveau de Toulouse. (ISCT), Université Toulouse - Jean Jaurès (UT2J), Université de Toulouse (UT)-Université de Toulouse (UT)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Centre Hospitalier Universitaire de Toulouse (CHU Toulouse)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Toulouse - Jean Jaurès (UT2J), Université de Toulouse (UT)-Centre Hospitalier Universitaire de Toulouse (CHU Toulouse)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS)-École normale supérieure - Lyon (ENS Lyon)-Centre National de la Recherche Scientifique (CNRS)-École normale supérieure - Lyon (ENS Lyon)-Inria Grenoble - Rhône-Alpes, Université Toulouse - Jean Jaurès (UT2J)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-CHU Toulouse [Toulouse]-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Toulouse - Jean Jaurès (UT2J)-Université Toulouse III - Paul Sabatier (UT3), and Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-CHU Toulouse [Toulouse]-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS)
- Subjects
Adenoma ,Male ,medicine.medical_specialty ,Metabolic Clearance Rate ,medicine.medical_treatment ,Clinical Biochemistry ,Population ,030232 urology & nephrology ,Urology ,Prostatic Hyperplasia ,urologic and male genital diseases ,03 medical and health sciences ,0302 clinical medicine ,Prostate ,medicine ,Biomarkers, Tumor ,Humans ,education ,Aged ,Aged, 80 and over ,education.field_of_study ,business.industry ,Prostatectomy ,Half-life ,Prostatic Neoplasms ,General Medicine ,Blood Proteins ,Middle Aged ,Prostate-Specific Antigen ,[INFO.INFO-MO]Computer Science [cs]/Modeling and Simulation ,NONMEM ,Blood Cell Count ,Prostate-specific antigen ,Kinetics ,medicine.anatomical_structure ,Standard error ,030220 oncology & carcinogenesis ,Creatinine ,Prostate surgery ,business - Abstract
International audience; OBJECTIVES: A population kinetic approach based on PSA clearance (CL(PSA)) may be a more rational strategy to characterize prostate-specific antigen (PSA) decrease profile after prostate surgery than the commonly used method (half-life from mono/bi-exponential models). METHODS: We used 182 post-adenomectomy PSA concentrations from 56 benign prostatic hyperplasia patients to build, with NONMEM software, a multi-exponential and a CL(PSA) model for comparison. RESULTS: The best multi-exponential model was PSA(t)=4.96e(-)(0.269t)+3.10e(-)(0.16t)+0.746e(+)(0.0002t) with a stable median residual PSA at 0.64 ng/mL. The best model parametrized with clearance was CL(PSA)=0.0229()(AGE/69)(3.78). Akaike information criteria and standard errors favored the CL(PSA) model. Median peripheral zone and transitional zone productions were 0.034 ng/mL/cm(3) and 0.136 ng/mL/g. A threshold at 2 ng/mL on day 90 allowed for a diagnostic of biochemical relapse diagnostic. CONCLUSIONS: The population CL(PSA) model was superior to the multi-exponential approach for investigating individual post-adenomectomy PSA decreases.
- Published
- 2008
22. Preservation of prostate during radical cystectomy: evaluation of prevalence of prostate cancer associated with bladder cancer
- Author
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D. Champetier, Alain Ruffion, N. Berger, Paul Perrin, Lopez Jg, Myriam Decaussin, A. Manel, W. Massoud, Nicolas Morel-Journel, Philippe Paparel, and Marian Devonec
- Subjects
Nephrology ,Adult ,Male ,medicine.medical_specialty ,Urology ,medicine.medical_treatment ,Cystectomy ,Neoplasms, Multiple Primary ,Prostate cancer ,Prostate ,Internal medicine ,medicine ,Prevalence ,Humans ,Aged ,Retrospective Studies ,Bladder cancer ,medicine.diagnostic_test ,business.industry ,Genitourinary system ,Prostatic Neoplasms ,Retrospective cohort study ,Rectal examination ,Middle Aged ,medicine.disease ,medicine.anatomical_structure ,Urinary Bladder Neoplasms ,business - Abstract
Objectives To estimate the frequency and characteristics of prostatic lesions discovered incidentally in radical cystoprostatectomy specimens and to determine whether any factors would allow for the detection of prostate cancer preoperatively. Methods A total of 100 radical cystoprostatectomy specimens with orthotopic bladder reconstruction were performed for malignant bladder disease between 1990 and 2000. The mean patient age at surgery was 62 ± 8 years (range 32 to 75). Digital rectal examination and prostate-specific antigen (PSA) assay were done routinely before surgery. During the 10-year study period, the same pathologist examined the prostatic tissues from radical cystoprostatectomy specimens using McNeal’s technique on fine slices every 2.5 mm. Results The overall incidence of prostate cancer discovered incidentally in radical cystoprostatectomy specimens was 51%, of which 29% were microcancers (volume less than 0.5 cm 3 ) and 22% were significantly larger (volume 0.5 cm 3 or more). The mean Gleason score was 6. Of the tumors, 24% could be considered “clinically nonsignificant” (less than 0.5 cm 3 and Gleason score less than 7). The mean preoperative PSA level was 4.13 ± 1.36 ng/mL. Of 66 patients with a PSA level of less than 4 ng/mL (mean PSA 1.5 ± 0.8) and a normal digital rectal examination before surgery, 50% had prostate cancer, of which 69% were microcancers. Conclusions The prevalence of prostate cancer (51%) in our series is among the highest in published reports. Furthermore, our results stress that currently no factors are available to enable the detection of “clinically significant” prostate cancer preoperatively.
- Published
- 2004
23. Immunocyt test improves the diagnostic accuracy of urinary cytology: results of a French multicenter study
- Author
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Denis Chautard, Dominique Chopin, Paul Perrin, Pascal Rischmann, Christian Pfister, Christian Coulange, Olivier Bouchot, Daniel Beurton, Marian Devonec, and Jean-Jacques Rambeaud
- Subjects
Adult ,Male ,medicine.medical_specialty ,Urology ,Urinary system ,Cytodiagnosis ,Urine ,Sensitivity and Specificity ,Cytology ,medicine ,Carcinoma ,Biomarkers, Tumor ,Humans ,Prospective Studies ,Urine cytology ,Aged ,Aged, 80 and over ,Carcinoma, Transitional Cell ,Urinary bladder ,Bladder cancer ,medicine.diagnostic_test ,business.industry ,Mucins ,Antibodies, Monoclonal ,Cystoscopy ,Middle Aged ,medicine.disease ,Immunohistochemistry ,Surgery ,Carcinoembryonic Antigen ,medicine.anatomical_structure ,Transitional cell carcinoma ,Urinary Bladder Neoplasms ,Female ,Radiology ,business - Abstract
The limitations of urinary cytology and the invasiveness of cystoscopy generate an increasing interest in noninvasive diagnostic tools for the management of transitional cell carcinoma. We assess the clinical performance of ImmunoCyt (DiagnoCure, Inc., Saint-Foy, Canada) in the detection of bladder cancer in a 10-center French trial.From October 2000 to April 2001, 694 patients undergoing cystoscopy were prospectively included in the study. Of the patients 458 (66%) had been previously treated for superficial transitional cell carcinoma and 236 (34%) were referred for symptoms suggestive of bladder cancer. All patients underwent ImmunoCyt test and standard urinary cytology from voided urine as well as a complete evaluation including cystoscopy and transurethral resection or biopsy of suspicious lesions. Sensitivity and specificity values of urinary cytology and ImmunoCyt whether or not combined were calculated using cystoscopy as the gold standard and histopathology when available.A total of 85 recurrent and 58 newly diagnosed bladder tumors were diagnosed by cystoscopy and histologicaly confirmed. Overall sensitivity of urinary cytology was 17.9%, 46.3% and 63.8% respectively, for G1, G2 and G3 transitional cell carcinoma, whereas that of ImmunoCyt was 60.7%, 75.6% and 76.8%. Sensitivity of the combined tests was 66.7%, 78% and 87%, respectively. Moreover, 10 of 55 (18.2%) new pT1 and pT2 or greater tumors were diagnosed by ImmunoCyt alone. Specificity of urinary cytology was 94.5%, whereas that of ImmunoCyt was 84.2%. Specificity of the combined tests was 80.7%. Marked variations in urinary cytology sensitivity were observed among the different centers (27.3% to 66.7%), whereas combined assays (urinary cytology and ImmunoCyt) enhanced the overall sensitivity in the 80% range at most centers.This prospective multicenter series confirmed a marked increase in sensitivity without significant loss in specificity when including ImmunoCyt in standard urinary cytology protocol. This increased sensitivity was observed in high grade lesions (with 100% sensitivity for carcinoma in situ) as well in low grade, low stage tumors.
- Published
- 2003
24. 190 DISCONTINUANCE OF BCG INSTILLATION FOR NONMUSCLE INVASIVE BLADDER CANCER: PROGNOSTIC IMPACT ON RECURRENCE
- Author
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A. Picard, Xavier Martin, D. Champetier, Marc Colombel, Marian Devonec, and Paul Perrin
- Subjects
Oncology ,medicine.medical_specialty ,Bladder cancer ,business.industry ,Urology ,Internal medicine ,medicine ,business ,medicine.disease - Published
- 2010
25. Impact de la chimiothérapie néoadjuvante sur la prise en charge chirurgicale des tumeurs de vessie infiltrant le muscle
- Author
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Aude Flechon, Xavier Martin, Marian Devonec, Hakim Fassi-Fehri, Marc Colombel, A. Ruffion, S. Tartas, and V. Meyer
- Subjects
Gynecology ,medicine.medical_specialty ,business.industry ,Urology ,medicine ,business - Published
- 2013
26. Injection of Hyaluronic Acid (HA) to Better Preserve the Rectal Wall in Prostate Hypofractionated Radiation Therapy (HFR)
- Author
-
P. Jalade, O. Chapet, Marie-Pierre Sotton, Ciprian Enachescu, Corina Udrescu, Alain Ruffion, Marian Devonec, Marc Colombel, and D. Azria
- Subjects
Cancer Research ,medicine.medical_specialty ,Radiation ,Hypofractionated Radiation Therapy ,business.industry ,Urology ,Surgery ,chemistry.chemical_compound ,medicine.anatomical_structure ,Oncology ,Rectal wall ,chemistry ,Prostate ,Hfr cell ,Hyaluronic acid ,medicine ,Radiology, Nuclear Medicine and imaging ,business - Published
- 2012
27. Injection of hyaluronic acid (HA) to better preserve the rectal wall in prostate hypofractionated radiotherapy (HFR)
- Author
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P. Jalade, Olivier Chapet, Marian Devonec, Alain Ruffion, Nabil Zahra, David Azria, Corina Udrescu, Christophe Mazzara, Marc Colombel, Marion Vincent, and Marie-Pierre Sotton
- Subjects
Hypofractionated Radiotherapy ,Cancer Research ,medicine.medical_specialty ,business.industry ,Rectum ,Phases of clinical research ,Cancer ,medicine.disease ,Surgery ,chemistry.chemical_compound ,medicine.anatomical_structure ,Oncology ,chemistry ,Prostate ,Hfr cell ,Hyaluronic acid ,medicine ,Local anesthesia ,business ,Nuclear medicine - Abstract
202 Background: Several studies are in favor of an α/β ratio of less than 3Gy for prostate (P) cancer, encouraging HFR. However, the development of such radiation patterns can only be done if the risk of rectal toxicity is well controlled. The objective of the present study was to evaluate the contribution of an injection of HA between the rectum and the P to reduce the risk of rectal toxicity in a HFR approach. Methods: A phase II study of HFR at 62Gy in 20 fractions (BED = 84Gy; α / β = 1.5Gy) is currently conducted. A transperineal injection of 10cc of HA (NASHA Spacer gel, Q-Med AB, Uppsala, Sweden) is systematically performed, between the rectum and the P, under local anesthesia and under ultrasound guidance. A dosimetric CT scan is performed before (CT1) and after injection (CT2). Patients are treated with a 7 beams IMRT plan, optimized on the CT2. For the first 10 patients included in the study, the same treatment plan was optimized on CT1. The rectum was empty on the 2 CTs and defined from 2cm above the seminal vesicles to 2 cm below the P. The rectal wall was defined by an internal expansion of 5 mm. The volumes of rectum irradiated, with and without HA, were compared on the following dosimetric parameters: maximum dose (D max), dose to 2.5cc (D2.5), 5cc (D5) and 10cc (D10) of rectal wall and volume of rectum receiving 90% (V90), 80% (V80) and 70% (V70) of the prescribed dose of 62Gy. To limit a potential impact of variation of rectal volume between the two CT, all results are given in cc and not in % of volume. Results: The mean P volume was 52.4cc (30cc - 93.8cc) on the CT1 and 52cc (32.5 - 92.7) on the CT2. The injection of HA reduced the mean D max value to the rectal wall of 4.5Gy (57.5Gy vs 62 Gy). The mean values of V90, V80, and V70 are reduced by 69% (1.9cc vs 6.1cc), 46% (4.5cc vs 8.4cc) and 32% (7.4cc vs 10.9cc). Same way, the average values of D2.5, D5 and D10 are reduced by 6.2 Gy (54.6Gy vs 60.8Gy) 9.3Gy (49.0Gy vs 58.3Gy) and 7.8Gy (39.7Gy vs 47.5Gy). Conclusions: In this study, the injection of HA limited the doses to the rectal wall. These results suggest that late toxicities could be significantly reduced. A phase II study is underway to assess the rate of late rectal toxicities when a HFR at 62Gy in 20 fractions is combined with an injection of HA.
- Published
- 2012
28. Transurethral Microwave Thermotherapy
- Author
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Patrice Joubert, Jean-Philippe Fendler, Marian Devonec, and Paul Perrin
- Subjects
medicine.medical_specialty ,business.industry ,Urinary retention ,Transurethral microwave thermotherapy ,medicine.medical_treatment ,Ultrasound ,Urology ,Urethral stent ,Hyperplasia ,medicine.disease ,Bladder outlet obstruction ,medicine.anatomical_structure ,Prostate ,Medicine ,medicine.symptom ,business ,Sexual function - Abstract
For almost a decade, transurethral microwave thermotherapy has been a progressively viable minimally invasive treatment option for benign prostatic hyperplasia. Treatments have evolved from low-energy to high-energy protocols with increasingly better objective results, albeit at the cost of a somewhat increased morbidity. Nevertheless, symptomatic improvement remained highly satisfactorily, and long-term durability results also appeared to be better with high-energy protocols. Recent changes in treatment algorithms resulted in reduced treatment time at even higher energy levels without compromising the objective results. Morbidity with thermotherapy treatment mainly consists of prolonged urinary retention with the need for catheterization when applying the high-energy protocols. High-energy protocols also have a greater impact on sexual function compared with the low-energy protocols. It appeared that patients with higher grades of bladder outlet obstruction and patients with larger prostates were the best candidates for the high-energy protocols. Histological studies, in combination with ultrasound contrast agents in enhanced color Doppler studies, are aimed at clarification of the vascularization of the prostate to identify predictive intrinsic prostate parameters. Further advances in the technology itself are aimed at the development of treatment probes allowing intraprostatic temperature measurement, preferably with feedback mechanisms to regulate the amount and type of energy. The morbidity caused by prolonged catheterization might be reduced by the use of biodegradable and nonresorbable temporary urethral stents.
- Published
- 1994
29. 888 CONTINENCE AFTER OPEN RADICAL PROSTATECTOMY: 82 % PATIENTS DRY AT FOLEY REMOVAL ON POST- OPERATIVE DAY 4. A COMMON OR UNUSUAL PERFORMANCE OF A SINGLE LOW VOLUME CENTER, IN A PROSPECTIVE SERIES OF 100 CASES?
- Author
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D. Champetier, Paul Perrin, E. Adam, A. Ruffion, M.J. Morel Journel, V. Meyer, Philippe Paparel, and Marian Devonec
- Subjects
Low volume ,medicine.medical_specialty ,Foley ,business.industry ,Prostatectomy ,Urology ,medicine.medical_treatment ,Medicine ,Center (algebra and category theory) ,Post operative ,business ,Surgery - Published
- 2011
30. Retraction of Authorship
- Author
-
A. Papatsoris, Taku Misumi, Tomoyuki Murakami, Tahir Qayyum, A. Meye, Viet Tran, Rahmene Azzouzi, Kazuhiro Nagao, Gilda Alves, Arnulf Stenzl, Kohsuke Sasaki, F. Marchese, Cag Cal, M. Gajda, Rashad Mammadov, Kristina Hotakainen, I. Ioannou, Takahiko Hara, Jörg Hennenlotter, Donald C. McMillan, Heinz-Peter Schlemmer, David Schilling, Ljiljana Paras, G. Morgia, Marian Devonec, Christian Saussine, Shigeru Sakano, Omer Kutlu, Ulf-Håkan Stenman, Hideyasu Matsuyama, Daniela Colleselli, Adnan Şimşir, Olivier Dumonceau, I. Pirozhok, Luis Arenas, José M. Martínez-Jabaloyas, Satoshi Eguchi, Matthias P. Lichy, Erkan Kismali, Friedhelm Wawroschek, Badereddin Mohamad Al-Ali, J. Masood, J. Fichtner, Roman Szlauer, M. Madonia, Claudius Fuellhase, Olivier Haillot, F. Aragona, M.P. Wirth, Charles Ballereau, Antonio A. Ornellas, Karl Pummer, Bertrand Lukacs, Pascual Chuan-Nuez, Manuel Gil-Salom, Alexander Winter, A. Galia, Francois Desgrandchamps, Denise A. Pereira, G. Mucciardi, Kazumi Suzuki, Tatsuo Morita, Levent A. Guner, Ismail Turker Koksal, Kazuhiko Nakano, Martti Ala-Opas, Marc Fourmarier, Ursula Kuehs, I. Petersen, T. Steiner, Salih Sanlioglu, Rolf-Peter Henke, G. Bonvissuto, J. Gelister, Richard Zigeuner, T. Castelli, Hideaki Ito, F. Fraggetta, U. Settmacher, A. Galì, G. Shaw, Christian Schwentner, Stephan A. Krueger, Alexandre de la Taille, Gurhan Gunaydin, G. Candiano, S. Fuessel, Ahter Dilsad Sanlioglu, Jens Uphoff, Vanessa Sandim, Grégoire Robert, P. Pepe, Katsusuke Naito, Sherif R. Aboseif, Harri Visapää, G. Grasso, Harald Trummer, Seiji Yano, P A McArdle, Nicolas Barry Delongchamps, Rafael Villamón-Fort, Yoshiaki Yamamoto, Ulrich H. Vogel, John Brusky, Aurélien Descazeaud, C. Magno, Klaus G. Fink, N. Buchholz, J. Zanow, Johan Lundin, L. Macchione, G. Romano, T. Briggs, Jocelyn M. Rieder, H. Wunderlich, O.W. Hakenberg, Karen Stern, Yoshihisa Kawai, Rany Shamloul, N. Kroeger, and A. Di Benedetto
- Subjects
business.industry ,Urology ,Medicine ,Engineering ethics ,business - Published
- 2010
31. A useful monoclonal antibody (BL2-10D1) to identify tumor cells in urine cytology
- Author
-
Jean-Claude Laurent, Nicole Berger-Dutrieux, Bernard Fontaniere, Arlette Longin, and Marian Devonec
- Subjects
Cancer Research ,Pathology ,medicine.medical_specialty ,Urine ,urologic and male genital diseases ,Immunoenzyme Techniques ,medicine ,Carcinoma ,Humans ,False Positive Reactions ,Urine cytology ,Carcinoma, Transitional Cell ,Bladder cancer ,Urinary bladder ,medicine.diagnostic_test ,Immunoperoxidase ,business.industry ,Carcinoma in situ ,Cancer ,Antibodies, Monoclonal ,medicine.disease ,female genital diseases and pregnancy complications ,medicine.anatomical_structure ,Oncology ,Urinary Bladder Neoplasms ,business ,Carcinoma in Situ - Abstract
The monoclonal antibody (MoAb) BL2-10D1 directed against a tumor-associated antigen of human bladder cancer was used to identify tumor cells obtained by bladder washing or voided urine. The reactivity of BL2-10D1 MoAb was detected by an immunoperoxidase method and evaluated in ten healthy donors and in a series of 65 patients. The 65 patients studied were divided into three groups: ten with nontumor bladder disease (group A); 36 with bladder carcinoma (group B); and 19 with a history of bladder neoplasia but no visible tumor at the time of cytologic sampling (group C). The results were compared with the standard cytologic diagnosis on Papanicolaou-stained preparations. Conventional cytologic study showed a high false-negative rate in low-grade tumors (transitional cell carcinomas [TCC] Grades 1 and 2, 1/4 and 4/17, respectively). All urine from patients with a histologically proved TCC Grade 1 were stained with BL2-10D1 MoAb. Cytologic findings from patients with TCC Grade 2 (17 cases) contained positive cells in 14 cases and failed to react in three cases. Furthermore, whereas urine from patients with TCC Grade 2 or 3 was not always stained with BL2-10D1 MoAb, all patients with dysplastic lesions (three cases) or carcinoma in situ (5 cases) showed a positive reactivity. Such results suggest that BL2-10D1 MoAb may be considered as a valuable adjunct to the classical methods of early detection and follow-up of bladder cancer. However, a larger scale study is needed for MoAb BL2-10D1 to be proposed as an aid to improve the diagnostic sensitivity of urine cytologic investigation in the follow-up of patients treated for recurring bladder cancer, and for the screening of workers exposed to potent bladder carcinogens.
- Published
- 1990
32. REMEEX® SYSTEM: A THERAPEUTIC OPTION IN SELECTED CASES OF STRESS URINARY INCONTINENCE WITH INTRINSIC SPHINCTER DEFICIENCY (ISD)
- Author
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Alain Ruffion, Philippe Paparel, B. Leriche, A. Leriche, J.L. Campos-Fernandes, and Marian Devonec
- Subjects
medicine.medical_specialty ,business.industry ,Urology ,Intrinsic sphincter deficiency ,medicine ,Urinary incontinence ,medicine.symptom ,business ,System a - Published
- 2006
33. SUPERFICIAL UROTHELIAL BLADDER TUMOURS: IDENTIFICATION OF A SET OF GENE CANDIDATES TO DISTINGUISH PTA AND PT1 STAGES
- Author
-
Alain Ruffion, Paul Perrin, J. André, Philippe Paparel, Bringuier Pp, C. Grenot, Myriam Decaussin, F. Descotes, Marian Devonec, and J.L. Campos-Fernandes
- Subjects
Set (abstract data type) ,business.industry ,Urology ,Medicine ,Identification (biology) ,Computational biology ,business ,Gene - Published
- 2006
34. URINARY SURVIVIN IS A BIOMARKER FOR THE DIAGNOSIS OF INVASIVE BLADDER CANCER
- Author
-
Alain Ruffion, Myriam Decaussin, F. Descotes, Philippe Paparel, Paul Perrin, R.C. Boisson, Marian Devonec, J. André, J.L. Campos-Fernandes, and D. Collin-chavagnac
- Subjects
Oncology ,medicine.medical_specialty ,Bladder cancer ,business.industry ,Urology ,Internal medicine ,Urinary system ,Survivin ,medicine ,Biomarker (medicine) ,business ,medicine.disease - Published
- 2006
35. Ex Vivo Tumorectomy on Transplanted Kidney
- Author
-
Sandra Genevois, Alain Ruffion, Philippe Paparel, Marian Devonec, and R. Cahen
- Subjects
Transplantation ,Creatinine ,Pathology ,medicine.medical_specialty ,business.industry ,Transplanted kidney ,medicine.disease ,chemistry.chemical_compound ,chemistry ,medicine ,Adenocarcinoma Clear Cell ,business ,Kidney transplantation ,Ex vivo - Published
- 2005
36. Caspases are involved in benign prostatic hyperplasia (BPH) induced apoptosis by finasteride
- Author
-
Aline Bozec, Myriam Decaussin, Marian Devonec, Alain Ruffion, C. Mauduit, and M. Benahmed
- Subjects
medicine.medical_specialty ,biology ,business.industry ,Urology ,medicine.disease ,chemistry.chemical_compound ,chemistry ,Apoptosis ,biology.protein ,Finasteride ,Medicine ,Benign prostatic hyperplasia (BPH) ,business ,Caspase - Published
- 2003
37. Follow-up after transurethral resection (TUR) for bladder cancer: Predictive value of UCYT+TM test in patients with negative cystoscopy
- Author
-
J. Faynel, F. Collet, Paul Perrin, Alain Ruffion, E. Piaton, Jean-Gabriel Lopez, M. Hoch, and Marian Devonec
- Subjects
medicine.medical_specialty ,Bladder cancer ,medicine.diagnostic_test ,business.industry ,Urology ,Cystoscopy ,medicine.disease ,Predictive value ,Resection ,Test (assessment) ,medicine ,In patient ,business - Published
- 2003
38. High prevalence of prostate cancer associated with bladder cancer
- Author
-
A. Manel, Marian Devonec, N. Morel Journel, Paul Perrin, N. Berger, Alain Ruffion, and Myriam Decaussin
- Subjects
Oncology ,Prostate cancer ,medicine.medical_specialty ,Bladder cancer ,High prevalence ,business.industry ,Urology ,Internal medicine ,Epidemiology of cancer ,Medicine ,Cancer ,business ,medicine.disease - Published
- 2003
39. Long-term recurrence of primary amyloidosis of the bladder
- Author
-
C. Valignat, Alain Ruffion, Marian Devonec, D. Champetier, Paul Perrin, and Lopez Jg
- Subjects
Aged, 80 and over ,Male ,medicine.medical_specialty ,medicine.diagnostic_test ,business.industry ,Urology ,Amyloidosis ,Urinary Bladder Diseases ,Computed tomography ,Cystoscopy ,medicine.disease ,Surgery ,medicine.anatomical_structure ,Recurrence ,medicine ,Humans ,Radiology ,Tomography, X-Ray Computed ,business ,Pelvis ,Aged ,Follow-Up Studies - Abstract
An 84-year-old man presented to our department with a recurrence of a primary amyloidosis of the bladder 14 years after the first diagnosis. Follow-up had been stopped 5 years after the first procedure because no cystoscopic anomalies were noted. General evaluation confirmed the diagnosis of primary amyloidosis. The lesions were endoscopically resected. At the 3-year follow-up, the patient was free of symptoms and had remained cystoscopically free of disease. However, stable amyloidosis deposits have always been noted on the computed tomography scans. This case emphasizes the necessity of a longer follow-up, including computed tomography of the pelvis, during the 10 to 15 years after the first occurrence of the disease.
- Published
- 2002
40. Twelve core biopsy improves prostatic cancer detection rate
- Author
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Paul Perrin, D. Champetier, Jean-Gabriel Lopez, Alain Ruffion, Nicole Berger-Dutrieux, Marian Devonec, Myriam Decaussin, and Dorel Soroiu
- Subjects
Oncology ,PCA3 ,medicine.medical_specialty ,business.industry ,Urology ,Internal medicine ,medicine ,Radiology ,Cancer detection ,business ,Core biopsy - Published
- 2002
41. The effectiveness of ImmunoCyt™ test system in the diagnosic of bladder cancer: french multicentric study
- Author
-
C Coulange, Olivier Bouchot, Paul Perrin, D. Chautard, Christian Pfister, J.J. Rambeaud, Dominique Chopin, Marian Devonec, Daniel Beurton, and Pascal Rischmann
- Subjects
Oncology ,medicine.medical_specialty ,Bladder cancer ,business.industry ,Urology ,Internal medicine ,Medicine ,business ,medicine.disease ,Test (assessment) - Published
- 2002
42. Bladder cancer diagnosis by flow cytometry. Correlation between cell samples from biopsy and bladder irrigation fluid
- Author
-
T Sharpless, Lars G. Collste, Frank Traganos, Marian Devonec, Myron R. Melamed, Zbigniew Darzynkiewicz, and Willet F. Whitmore
- Subjects
Cancer Research ,Pathology ,medicine.medical_specialty ,Bladder cancer ,medicine.diagnostic_test ,business.industry ,Carcinoma in situ ,Therapeutic irrigation ,medicine.disease ,Bladder Irrigation ,Stain ,Oncology ,Biopsy ,medicine ,Papilloma ,Sampling (medicine) ,business - Abstract
Results of flow cytometry (FCM) examinations of bladder irrigation specimens were compared with those of FCM examinations of cell suspensions from bladder biopsies of 44 urologic patients. The fluorescent dye, acridine orange (AO), was used to stain DNA and RNA differentially and abnormal urothelial cells were identified by their relative content of nucleic acids. Granulocytes and squamous cells could be distinguished from transitional cells in this procedure, and did not interfere with the analyses. Of 28 patients with papillary carcinoma, carcinoma in situ, and invasive carcinoma 27 were identified through FCM examination of irrigation cytology specimens; the one false-negative result was from a low-grade papillary carcinoma. Of 7 patients with papilloma, FCM examinations of irrigation specimens were positive in 4 and negative in 3. Results of FCM studies of biopsy specimens were in good but not complete agreement with those of irrigation specimens. In several cases, irrigation FCM disclosed tumor stemlines that were not identified in biopsy specimens. Discrepancies of this kind seemed most likely due to differences in sampling. Irrigation FCM seems to be a sensitive method for assessing multiple-site bladder tumors, and may be a useful technique for monitoring the course of conservatively managed bladder tumors.
- Published
- 1980
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