1. Is the Institute Georges Lopez-1 solution an equally effective, cheaper alternative to the University of Wisconsin solution in liver transplantation?
- Author
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Goutham Kumar, Olithselvan Arikichenin, Sanjay Govil, Suresh Doraiswamy, Navaneethan Subramanian, Ravichand Siddachari, and Magnus Mansard
- Subjects
Transplantation ,Deceased donor ,Graft dysfunction ,medicine.medical_specialty ,liver allograft function/dysfunction ,Adult patients ,business.industry ,Economics ,organ perfusion and preservation ,Incidence (epidemiology) ,medicine.medical_treatment ,lcsh:Surgery ,lcsh:RD1-811 ,Liver transplantation ,Surgery ,Liver transaminases ,Medicine ,Viaspan ,business ,Liver preservation - Abstract
Aim: To compare the outcomes of deceased donor liver transplantation (DDLT) using either the University of Wisconsin solution (UW) or the Institute Georges Lopez-1 (IGL-1) solution. Materials and Methods: Adult patients who underwent DDLT between November 2015 and March 2018 were included in the study. All patients received grafts from brain-dead donors. In 30 patients, the UW solution was used to preserve the liver and in 53 patients, the IGL-1 solution was used. The data of these two groups of the patients were analyzed and compared. Results: Between the two groups of patients, donor and recipient demographics and surgery-related variables were found to be similar. No difference was observed in the incidence of postreperfusion syndrome, number of days of hospitalization, and in the 30-day mortality. Early graft dysfunction was observed in 9 (16.98%) patients in the IGL-1 group and in 7 (23.33%) patients in the UW group (P = 0.48). One patient had primary nonfunction in each group. The postoperative levels of the liver transaminases were also not found to be significantly different. Conclusions: The efficacies of liver preservation by the IGL-1 and UW solutions were found to be comparable.
- Published
- 2019