31 results on '"M. Sastre"'
Search Results
2. Predictors of good visual outcomes in patients with neovascular age-related macular degeneration in daily practice
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M. Prieto-del-Cura, M. Sastre-Ibañez, E. Recio-Gamo, M.-E. Fuentes-Ferrer, and I. Villafruela-Güemes
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Male ,Vascular Endothelial Growth Factor A ,medicine.medical_specialty ,Visual acuity ,genetic structures ,Bevacizumab ,Visual Acuity ,Angiogenesis Inhibitors ,Fundus (eye) ,Loading dose ,Biomarkers, Pharmacological ,Macular Degeneration ,03 medical and health sciences ,0302 clinical medicine ,Interquartile range ,Ophthalmology ,medicine ,Humans ,Practice Patterns, Physicians' ,Aged ,Retrospective Studies ,Aged, 80 and over ,Neovascularization, Pathologic ,business.industry ,Retrospective cohort study ,Macular degeneration ,Prognosis ,medicine.disease ,eye diseases ,Regimen ,Treatment Outcome ,Intravitreal Injections ,030221 ophthalmology & optometry ,Female ,sense organs ,medicine.symptom ,business ,medicine.drug - Abstract
Summary Purpose To report predictive factors for therapeutic response to anti-VEGF in patients with neovascular age-related macular degeneration (nAMD) in daily clinical practice in our patient population. Methods Retrospective cohort study including 56 patients (69 eyes) with nAMD treated with anti-VEGF, followed for at least two years between February 2012 and April 2018. Patients received three intravitreal anti-VEGF (bevacizumab) injections (loading dose) and were monitored and treated according to a PRN regimen. We analysed whether a gain in visual acuity of 15 or more ETDRS letters at the final visit was associated with demographic characteristics, presence of systemic comorbidities, fundus lesions or measurable improvement on Cirrus optical coherence tomography (OCT) between the first and last visit. Results After a mean follow-up of 15.5 months (4.7–27.8 interquartile range), central retinal thickness (CRT) (RR: 1.004; IC 95%: 1.001–1.007; P = 0.011) and macular hemorrhage (RR: 0.30; IC 95%: 0.10–0.90, P = 0.032) at baseline were found to be useful predictive factors for visual acuity improvement (≥ 15 letters) in patients treated for nAMD by anti-VEGF in a real world clinical setting. Conclusion In the present series of patients with nAMD receiving a loading dose of bevacizumab and followed according to a PRN regimen for 24 months, the only predictable factors for a ≥ 15 letter gain in visual acuity were anatomical response as measured by OCT and macular hemorrhage at baseline.
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- 2020
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3. Macular involvement in a pigmented paravenous retinochoroidal atrophy
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S. Quijada Angeli, M.J. Crespo Carballés, M. Acebes Garcia, L. Jimeno Anaya, N. Pastora Salvador, M. Prieto del Cura, and M. Sastre-lbáñez
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Ophthalmology ,medicine.medical_specialty ,business.industry ,medicine ,Pigmented paravenous retinochoroidal atrophy ,Macular involvement ,business - Published
- 2020
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4. Corneal Topographic, Anatomic, and Biomechanical Properties in Severe Obstructive Sleep Apnea–Hypopnea Syndrome
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Jorge Peraza-Nieves, Almudena Asorey-García, Mauro G Dupré-Peláez, M. Sastre-Ibáñez, Pedro Arriola-Villalobos, Lucía Perucho-González, B. Benito-Pascual, and José Manuel Fernández-Sánchez-Alarcos
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Male ,medicine.medical_specialty ,Time Factors ,Polysomnography ,macromolecular substances ,Newly diagnosed ,Keratoconus ,Severity of Illness Index ,Cornea ,03 medical and health sciences ,0302 clinical medicine ,Internal medicine ,Severity of illness ,medicine ,Humans ,In patient ,Intraocular Pressure ,Aged ,Aged, 80 and over ,Sleep Apnea, Obstructive ,medicine.diagnostic_test ,business.industry ,Follow up studies ,Corneal Topography ,Sleep apnea ,Middle Aged ,Prognosis ,medicine.disease ,Elasticity ,respiratory tract diseases ,Obstructive sleep apnea ,Ophthalmology ,Cross-Sectional Studies ,030221 ophthalmology & optometry ,Cardiology ,Female ,business ,Hypopnea ,030217 neurology & neurosurgery ,Follow-Up Studies - Abstract
To determine corneal topographic, anatomic, and biomechanical properties in patients newly diagnosed with severe obstructive sleep apnea-hypopnea syndrome (OSAHS).This is a cross-sectional study including 25 patients recently diagnosed with severe OSAHS (apnea-hypopnea index above 30) and a paired control group of 25 healthy subjects. All patients underwent a complete eye examination with an elevation topography Pentacam Scheimpflug study and a study with Reichert Ocular Response Analyzer, collecting several topographic, anatomic, and biomechanical variables.Fifty eyes of 25 patients (23 of them were men) diagnosed with OSAHS by somnography and the same number of healthy subjects (23 of them were men) were included, with an average age of 64 ± 11 years (range 45-78 years) for cases and an average age of 64 ± 11 years (range 45-81 years) for the controls. No differences were found in keratometry, cylinder, refractive indexes, Bad-D, or pachymetry. The mean corneal volume for cases was 58.64 ± 3.05 mm and for the controls 60.48 ± 3.33 mm (P = 0.005). The mean minimum radius for cases was 7.49 ± 0.31 and for the controls 7.36 ± 0.30 (P = 0.035). The mean elevation in apex for cases was 8.46 ± 5.18 and for the controls 2.38 ± 2.36 (P ≤ 0.001). Two eyes with a topographic diagnosis of keratoconus (KC) and another 6 with subclinical KC were detected using the Pentacam in the OSAHS group.Many of the corneal topographic and biomechanical variables in patients with severe OSAHS present different values from the general population with a trend toward KC values, such as keratoconus index or paired keratoconus index. Compared with the control group, significant differences were found in corneal volume, corneal elevation, and minimum radius.
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- 2019
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5. Retinal pigment epithelial tears
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P. Martínez López-Corell, M. Sastre-Ibáñez, C. Martínez-Rubio, Roberto Gallego-Pinazo, Jose Fernando Arevalo, R. Molina-Pallete, and L. Wu
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Diagnostic Imaging ,medicine.medical_specialty ,medicine.medical_treatment ,Photodynamic therapy ,Retinal Pigment Epithelium ,chemistry.chemical_compound ,Risk Factors ,Ophthalmology ,medicine ,Humans ,In patient ,Rupture, Spontaneous ,business.industry ,Retinal Detachment ,Retinal ,Macular degeneration ,Retinal Perforations ,medicine.disease ,eye diseases ,Pathophysiology ,chemistry ,Etiology ,Tears ,sense organs ,Complication ,business - Abstract
A retinal pigment epithelial (RPE) tear is a well-known complication of retinal pigment epithelial detachments (PED) and may cause a significant visual impairment. The most common cause is a vascularized PED in patients with exudative age-related macular degeneration (AMD). The development of diagnostic imaging techniques brings us closer to the etiology and pathophysiological mechanisms of this entity, offering us new strategies for treatment and follow-up. The advent of intravitreal antiangiogenic treatment (anti-VEGF) has led to an increase in the number of reported cases of RPE tears, which are an important vision-limiting factor during treatment. However, RPE tears may occur spontaneously or as a consequence of thermal laser treatment, photodynamic therapy or anti-VEGF therapy. It is accepted that the mechanism of RPE tears is multifactorial. The optimization of the functional outcome of this complication has been described with continuous treatment with antiangiogenic drugs. The goal of the present review is to evaluate the incidence, risk factors and treatment of RPE tears.
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- 2019
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6. Overview of the main radiation transport codes
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N. Schetakis, R. Crespo, J. L. Vázquez-Poletti, M. Sastre, L. Vázquez, and A. Di Iorio
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Radiation transport ,Atmospheric Science ,010504 meteorology & atmospheric sciences ,Computer science ,business.industry ,Meteorología ,lcsh:QC801-809 ,Radiation dose ,Geology ,Mars Exploration Program ,Radiation ,Geofísica ,Oceanography ,Space (mathematics) ,01 natural sciences ,lcsh:Geophysics. Cosmic physics ,0103 physical sciences ,Range (statistics) ,Aerospace engineering ,Space research ,business ,010303 astronomy & astrophysics ,0105 earth and related environmental sciences - Abstract
Accurate predictions of expected radiation dose levels on Mars are often provided by specific radiation transport codes that have been adapted to space conditions. Unsurprisingly, several of the main space agencies and institutions involved in space research and technology tend to work with their own in-house radiation codes. We present the codes that are related to the simulation of the radiation on Mars' surface under different scenarios. All of these codes have similar fields of application, but they differ with respect to several aspects, including the energy range and types of projectiles considered as well as the models of nuclear reactions considered.
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- 2020
7. Behavior of hyperreflective foci in non- infectious uveitic macular edema, a 12- month follow-up prospective study
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Victor Llorenç, Alex Fonollosa, Ioana Ruiz-Arruza, José Ríos, Alfredo Adán, Pedro Arriola-Villalobos, M. Sastre-Ibáñez, Joseba Artaraz, Jessica Matas, Barbara Berasategui, David Díaz-Valle, and Universitat de Barcelona
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Male ,Visual acuity ,Time Factors ,genetic structures ,intraocular inflammation ,Visual Acuity ,microglia ,degeneration ,Hyperreflective foci ,chemistry.chemical_compound ,0302 clinical medicine ,lcsh:Ophthalmology ,Macula Lutea ,Prospective Studies ,Fluorescein Angiography ,Prospective cohort study ,visual outcomes ,hyperreflective foci ,General Medicine ,Diabetic retinopathy ,Middle Aged ,Ophthalmopathies ,Prognosis ,Retinal diseases ,medicine.anatomical_structure ,Malalties de la retina ,retinal vein occlusion ,Disease Progression ,uveitis ,Female ,Microglia ,medicine.symptom ,Oftalmopaties ,Uveitis ,Tomography, Optical Coherence ,medicine.drug ,Research Article ,spots ,Adult ,medicine.medical_specialty ,Micròglia ,Pronòstic mèdic ,Fundus Oculi ,dexamethasone ,Macular Edema ,03 medical and health sciences ,Young Adult ,uveitic macular edema ,Uveitic macular edema ,Ophthalmology ,medicine ,Humans ,Macular edema ,Dexamethasone ,Aged ,Retina ,diabetic-retinopathy ,optical coherence tomography ,Optical coherence tomography ,business.industry ,Retinal ,medicine.disease ,eye diseases ,chemistry ,lcsh:RE1-994 ,030221 ophthalmology & optometry ,Intraocular inflammation ,sense organs ,business ,030217 neurology & neurosurgery ,Follow-Up Studies - Abstract
Background: Hyperreflective foci have been described in OCT imaging of patients with retinal vascular diseases. It has been suggested that they may play a role as a prognostic factor of visual outcomes in these diseases. The purpose of this study is to describe the presence of hyperreflective foci in patients with non-infectious uveitic macular edema and evaluate their behavior after treatment. Methods: We conducted a multicenter, prospective, observational, 12-month follow-up study. Inclusion criteria were age > 18 years and a diagnosis of non-infectious uveitic macular edema, defined as central macular thickness of > 300 mu m as measured by OCT and fluid in the macula. Collected data included best corrected visual acuity, central macular thickness and the presence, number and distribution (inner or outer retinal layers) of hyperreflective foci. Evaluations were performed at baseline, and at 1, 3, 6, and 12 months after starting treatment. Results: We included 24 eyes of 24 patients. The frequency of patients with >= 11 hyperreflective foci was 58.4% at baseline, falling to 20.8% at 12 months. Further, hyperreflective foci were observed in the outer retinal layers in 50% of patients at baseline and just 28.6% at 12 months. Mean LogMAR visual acuity improved from 0.55 (95% CI 0.4-0. 71) at baseline to 0.22 (95% CI 0.08-0.35) at 12 months (p < 0.001). Mean central macular thickness decreased from 453.83 mu m (95% CI 396.6-511) at baseline to 269.32 mu m (95% CI 227.7-310.9) at 12 months (P < 0.001). Central macular thickness was associated with number (p = 0.017) and distribution (p = 0.004) of hyperreflective foci. Conclusions: We have observed hyperreflective foci in most of our patients with non-infectious uveitic macular edema. During follow-up and after treatment, the number of foci diminished and they tended to be located in the inner layers of the retina. This work was supported by grants from: Spanish Ministry of Economy, Industry and Competitivity, Carlos III Health Institute: PI 13/02148, cofinanced by the European Regional Development Fund.
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- 2018
8. Geographic atrophy: Etiopathogenesis and current therapies
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A. Barreiro-González, M. Sastre-Ibáñez, B. García-Armendariz, Roberto Gallego-Pinazo, and R. Dolz-Marco
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0301 basic medicine ,Pathology ,medicine.medical_specialty ,genetic structures ,Tomografia de coherencia optica ,Estres oxidativo ,Inflammation ,Drusen ,medicine.disease_cause ,Lipofuscin ,03 medical and health sciences ,0302 clinical medicine ,Atrophy ,Autofluorescencia ,Geographic Atrophy ,Medicine ,Humans ,Drusas ,Complement system proteins ,Proteinas del sistema del complemento ,Autofluorescence imaging ,Optical coherence tomography ,business.industry ,Inflamacion ,General Medicine ,Lipofuscina ,medicine.disease ,eye diseases ,Pathophysiology ,Complement system ,030104 developmental biology ,medicine.anatomical_structure ,Oxidative stress ,Atrofia geografica ,030221 ophthalmology & optometry ,sense organs ,Choroid ,Geographic atrophy ,medicine.symptom ,business - Abstract
Geographic atrophy is characterized by severe visual deficit whose etiology and pathophysiology are yet to be elucidated. As a working hypothesis, oxidative damage could trigger a chronic inflammation in Bruch's membrane-RPE-choriocapillaris complex, mostly due to complement pathway overactivation. Some individuals with mutations in the complement system and other factors have diminished capacity in the modulation of the inflammatory response, which results in cell damage and waste accumulation. This accumulation of intracellular and extracellular waste products manifests as drusen and pigmentary changes that precede the atrophy of photoreceptors, RPE, choriocapillaris with an ischemic process with decreased choroid flow. All these processes can be detected as tomographic findings and autofluorescence signals that are useful in the evaluation of patients with atrophic AMD, which helps to establish an individualized prognosis. Anti-inflammatory, antioxidant and therapies that decrease the accumulation of toxins for the preservation of the RPE cells and photoreceptors are being investigated in order to slow down the progression of this disease.
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- 2018
9. Membrane Processes in Waste Treatment for Chemical and Nuclear Industries: Recent Advances
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A. M. Sastre and A. K. Pabby
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Nuclear fuel cycle ,Waste treatment ,Lead (geology) ,Membrane ,Power consumption ,business.industry ,High mass ,Environmental science ,Separation method ,Solvent extraction ,Process engineering ,business - Abstract
Membrane technologies have seen a significant growth and increase in application in the last two decades. Membrane systems are now available in several different forms and sizes, each uniquely fitting a particular need and application. With the growing confidence to tailor–make membranes with desired characteristics, the applications can be extended to the separation / decontamination of a number of aqueous streams in chemical engineering or in the nuclear fuel cycle. The chemical and engineering communities are already paying significant attention to the quest for technologies that would lead us to the goal of technological sustainability. Amongst the various separation techniques, membrane based separation methods are getting increasingly popular due to factors such as high efficiency, and low in power consumption and easy scale–up due to a compact design etc. Also, in a modern approach, membrane contactors have proved to be an efficient contacting device, due to their high area per unit volume that results in high mass transfer rates. They are not only compact but also eliminate several of the problems faced in conventional processes such as ion exchange, solvent extraction, and precipitation.
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- 2017
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10. Health care in dementia: Satisfaction and needs of the caregiver
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M. Sastre Paz, J. Olazarán Rodríguez, and S. Martín Sánchez
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medicine.medical_specialty ,Activities of daily living ,business.industry ,MEDLINE ,Context (language use) ,Primary care ,medicine.disease ,lcsh:RC346-429 ,Family medicine ,Health care ,medicine ,Dementia ,Outpatient clinic ,Psychiatry ,business ,Simple correlation ,lcsh:Neurology. Diseases of the nervous system - Abstract
Introduction: Primary care (PC) and general neurology clinics (NC) assume the leading role in the health care of patients with dementia. There are hardly any studies on the satisfaction of the caregiver at these settings of health care. Methods: A questionnaire was designed and distributed to 75 caregivers of patients with dementia who were reviewed in an NC and who had been referred from PC. The questionnaire included questions associated with the care, the use of services, and satisfaction. Sociodemographic and clinical variables were also collected. The results of the questionnaire are described and a simple correlation analysis (Spearman r) was performed to determine the factors associated with satisfaction. Results: The majority of carers were sons or daughters (60%) or spouses (31%), of which 73% were women. The service most used was home help (36%), but 41% of patients had no services available. Satisfaction was high (84% quite or very satisfied with PC, 97% quite or very satisfied with the NC, P
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- 2012
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11. Lormetazepam bei der Behandlung von Schlafstörungen in der internistischen Praxis: Doppelblindprüfung an 100 Patienten
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H.-D. Hentschel, K. Fichte, and M. Sastre y Hernández
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medicine.drug_class ,business.industry ,Medical practice ,Lorazepam ,General Medicine ,Lormetazepam ,Double blind ,Hypnotic ,Anti-Anxiety Agents ,Anesthesia ,medicine ,HANGOVER EFFECT ,business ,Diazepam ,medicine.drug - Abstract
Lormetazepam (1 mg) and diazepam (5 mg) were compared in a double-blind study of 100 patients with sleep disorders associated with a medical illness. Assignment to one of two treatment groups was at random. Lormetazepam had a greater hypnotic effect than diazepam in all significant variables (P less than 0.05). There was no hangover effect or other side effects with lormetazepam, which was thus superior to diazepam also in this respect (P less than 0.05).
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- 2008
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12. Membrane néovasculaire secondaire à une lésion toxoplasmique cicatricielle
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David Díaz-Valle, M. Sastre-Ibáñez, N. Ávalos-Franco, and José Gegúndez-Fernández
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Ophthalmology ,Text mining ,medicine.diagnostic_test ,business.industry ,Medicine ,business ,medicine.disease ,Fluorescein angiography ,Nuclear medicine ,Toxoplasmosis - Published
- 2016
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13. Crouzon syndrome: Ophthalmologic complications in an untreated adult patient
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J L Lerma-Gallardo, Enrique Santos-Bueso, Julian Garcia-Feijoo, S. García-Sáenz, M Sastre-Ibáñez, and A García-Asorey
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Ophthalmology ,medicine.medical_specialty ,Exophthalmos ,business.industry ,medicine ,Dentistry ,Crouzon syndrome ,Craniofacial dysostosis ,medicine.symptom ,Hypertelorism ,business ,medicine.disease ,Dermatology - Published
- 2015
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14. Visual snow: Report of three cases
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Jesús Porta-Etessam, Enrique Santos-Bueso, M. Sastre-Ibáñez, and Julian Garcia-Feijoo
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Ophthalmology ,business.industry ,medicine ,Visual snow ,medicine.symptom ,business ,Cartography - Published
- 2015
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15. Dosimetric and radiation protection considerations based on some cases of patient skin injuries in interventional cardiology
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C Moro, Eliseo Vano, A Ledo, L Arranz, I Minguez, J M Sastre, and M T Gárate
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medicine.medical_specialty ,Adolescent ,medicine.medical_treatment ,Catheter ablation ,Radiation Dosage ,Radiography, Interventional ,Radiation Protection ,medicine ,Humans ,Dosimetry ,Radiodermatitis ,Radiology, Nuclear Medicine and imaging ,Cardiac Surgical Procedures ,Child ,Radiometry ,Retrospective Studies ,Interventional cardiology ,medicine.diagnostic_test ,business.industry ,Interventional radiology ,Retrospective cohort study ,General Medicine ,Erythema ,Radiological weapon ,Chronic Disease ,Catheter Ablation ,Female ,Radiation protection ,Nuclear medicine ,business - Abstract
Recently, several cases of skin injuries have been detected in patients undergoing cardiac radiofrequency catheter ablation. These procedures were performed on a biplane X-ray system used in a large Spanish hospital for interventional cardiology procedures. Interventional procedures performed and radiation lesions produced on patients are described. The radiation lesions were mainly erythematous lesions and chronic radiodermatitis. Results of the dosimetric evaluations and an analysis of the operational aspects of radiological protection are discussed. Poor image quality could have influenced the length of the procedures. Dose rate at the image intensifier entrance was within usual reported values in literature. However, the focus-to-skin distance for the horizontal X-ray beam was too short, resulting in a high skin dose rate. Additionally, X-ray beams are of fixed orientation, and accumulated skin dose in the patient's right side has been estimated as 11-15 Gy per procedure. In conclusion, practical radiation protection considerations to avoid further incidents of this sort are proposed, concerning the use of X-ray systems specially designed for interventional radiology, the improvement of cardiologists' training in radiation protection and routine patient dose measurements for complex interventional procedures.
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- 1998
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16. Nieve visual. ¿Del síntoma al síndrome?
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M. Sastre-Ibáñez, Federico Saenz-Frances, Enrique Santos-Bueso, Julian Garcia-Sanchez, and Jesús Porta-Etessam
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Ophthalmology ,business.industry ,Medicine ,business - Published
- 2015
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17. Visual snow. From a symptom to a syndrome?
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M. Sastre-Ibáñez, Julian Garcia-Sanchez, Jesús Porta-Etessam, Enrique Santos-Bueso, and Federico Saenz-Frances
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business.industry ,Migraine Disorders ,Vision Disorders ,Humans ,Medicine ,Syndrome ,General Medicine ,Visual snow ,medicine.symptom ,business ,Cartography - Published
- 2015
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18. Rolipram versus nortriptyline in gerontopsychiatric inpatients with major depression
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A. Korner, R. Bischoff, K. Behnke, M. Schratzer, B. Voet, M. Sastre-Y-Hernández, P. Arup, B. Mejer-Nielsen, and A. Geisler
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Base line ,medicine.medical_specialty ,business.industry ,Psychiatry and Mental health ,Anesthesia ,medicine ,Cholinergic ,Antidepressant ,In patient ,Nortriptyline ,Adverse effect ,business ,Psychiatry ,Depression (differential diagnoses) ,Rolipram ,medicine.drug - Abstract
To define the therapeutic profile of the new putative antidepressant rolipram, a double-blind (double-dummy) study with 0.5 mg rolipram versus 25 mg nortriptyline three times daily was conducted in hospitalized gerontopsychiatric inpatients with major depression. During both therapies, improvement was achieved compared with base line. However, the rate of recovery in patients treated with 3×25 mg nortriptyline was significantly greater than in those treated with 3×0.5 mg rolipram. Overall, rolipram was better tolerated than nortriptyline and produced fewer adverse effects that could be attributed to cholinergic blocking. We conclude that 3×0.5 mg rolipram presumably is too low a dosage for the treatment of major depression in gerontopsychiatric inpatients.
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- 1992
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19. Consequences of leaf calibration errors on IMRT delivery
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Dag Rune Olsen, J. Welleweerd, U.A. Van der Heide, Erik Malinen, M. Sastre-Padro, and K. Eilertsen
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Film Dosimetry ,Radiological and Ultrasound Technology ,business.industry ,Phantoms, Imaging ,Radiotherapy Planning, Computer-Assisted ,Reproducibility of Results ,Sensitivity and Specificity ,Gamma index ,Gamma analysis ,Head and Neck Neoplasms ,Calibration ,Humans ,Radiology, Nuclear Medicine and imaging ,Dose Fractionation, Radiation ,Particle Accelerators ,Nuclear medicine ,business ,Head and neck ,Artifacts ,Relative Biological Effectiveness ,Mathematics - Abstract
IMRT treatments using multi-leaf collimators may involve a large number of segments in order to spare the organs at risk. When a large proportion of these segments are small, leaf positioning errors may become relevant and have therapeutic consequences. The performance of four head and neck IMRT treatments under eight different cases of leaf positioning errors has been studied. Systematic leaf pair offset errors in the range of +/-2.0 mm were introduced, thus modifying the segment sizes of the original IMRT plans. Thirty-six films were irradiated with the original and modified segments. The dose difference and the gamma index (with 2%/2 mm criteria) were used for evaluating the discrepancies between the irradiated films. The median dose differences were linearly related to the simulated leaf pair errors. In the worst case, a 2.0 mm error generated a median dose difference of 1.5%. Following the gamma analysis, two out of the 32 modified plans were not acceptable. In conclusion, small systematic leaf bank positioning errors have a measurable impact on the delivered dose and may have consequences for the therapeutic outcome of IMRT.
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- 2007
20. P31.10: Benign metastasising leiomyoma: a case report of lung and pleural metastases
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Sonia Zaragoza Fernández, E. Cayuela, A. Lillo Paredes, M. Castellarnau, M. Sastre, and P. Regueiro
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Pathology ,medicine.medical_specialty ,Lung ,Radiological and Ultrasound Technology ,business.industry ,Obstetrics and Gynecology ,General Medicine ,medicine.disease ,Leiomyoma ,medicine.anatomical_structure ,Reproductive Medicine ,medicine ,Radiology, Nuclear Medicine and imaging ,business - Published
- 2014
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21. P13.18: Small-for-gestational age: a diagnosis challenge
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L. Acin Vinyeta, S. Fernandez, H. Ayuso, P. Regueiro, M. Arigita, E. Cayuela, and M. Sastre
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medicine.medical_specialty ,Reproductive Medicine ,Radiological and Ultrasound Technology ,Obstetrics ,business.industry ,medicine ,Obstetrics and Gynecology ,Small for gestational age ,Radiology, Nuclear Medicine and imaging ,General Medicine ,business ,medicine.disease - Published
- 2014
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22. PHP74 ELECTROMAGNETIC INTERFERENCES BETWEEN WIRELESS COMMUNICATION TECHNOLOGY AND CRITICAL CARE MEDICAL EQUIPMENT: A HEALTH TECHNOLOGY ASSESSMENT
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Zuleika Saz-Parkinson, J. M. Amate, M Sastre, and Carmen Bouza
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business.industry ,Computer science ,Health Policy ,Public Health, Environmental and Occupational Health ,Medical equipment ,Health technology ,Wireless ,Telecommunications ,business - Published
- 2009
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23. 269 Influence of factors affecting response to neoadjuvant chemotherapy in the design of the surgical approach to T2 and T3 breast tumours
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M. Sastre Cuadri, S. Servitja, V. Juncà, M. Segura, J.M. Corominas, R. Carreras Collado, J. Solsona, Marta Carrasco, M. Vernet Tomas, and S. Agramunt
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Oncology ,Cancer Research ,Chemotherapy ,medicine.medical_specialty ,Surgical approach ,business.industry ,medicine.medical_treatment ,Internal medicine ,Breast tumours ,Medicine ,business - Published
- 2010
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24. 321 Usefulness of clinical exploration, ultrasound and MRI for the assessment of axillary lymph nodes status previous to the performance of sentinel node
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S. Gomez-Carballo, M. Vernet-Tomas, M. Sastre, A. Rodríguez, Marta Carrasco, R. Carreras, S. Agramunt, and J.M. Corominas
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Cancer Research ,medicine.medical_specialty ,medicine.anatomical_structure ,Oncology ,Axillary lymph nodes ,business.industry ,Ultrasound ,medicine ,Radiology ,Sentinel node ,business - Published
- 2010
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25. α-2-Adrenoceptor and μ-opioid receptor densities in the postmortem brain of heroin addicts
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Jesús A. García-Sevilla, Ane M. Gabilondo, J. Javier Meana, M. Sastre, and Fernando Barturen
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Pharmacology ,medicine.medical_specialty ,Adrenergic receptor ,Postmortem brain ,medicine.drug_class ,business.industry ,Psychiatry and Mental health ,Endocrinology ,Neurology ,Opioid receptor ,Internal medicine ,medicine ,Pharmacology (medical) ,Neurology (clinical) ,business ,Biological Psychiatry ,Heroin addicts - Published
- 1992
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26. Sublingual lormetazepam in the treatment of sleep disorders in general practice patients
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P. Visser, B. Schütt, K. Fichte, and M. Sastre‐Y‐Hernandez
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Benzodiazepine ,medicine.drug_class ,business.industry ,Lormetazepam ,Placebo ,Sublingual administration ,Hypnotic ,Psychiatry and Mental health ,Neurology ,Anesthesia ,Concomitant ,medicine ,Insomnia ,Pharmacology (medical) ,Neurology (clinical) ,Sleep (system call) ,medicine.symptom ,business ,medicine.drug - Abstract
The sublingual form of the benzodiazepine hypnotic lormetazepam was developed with the aim of attaining greater flexibility in the treatment of sleep disorders. The object is to achieve rapid onset of hypnotic effect and provide patients with a form of medication which they can take after having gone to bed and only if they have difficulty in falling asleep. In a placebo-controlled crossover double-blind study the hypnotic effect, side-effects and acceptance of lormetazepam sublingual (1 mg) were investigated in 60 patients with sleep disorders receiving treatment from physicians in independent practices. The study was conducted over a total of 2 weeks, the patients receiving lormetazepam and placebo for 7 days respectively, changing over in the second week. The results show that in the sublingual form lormetazepam (1) is distinctly better than placebo as regards hypnotic efficacy, particularly with respect to the reduction of sleep latency; (2) does not lead to a significantly higher rate of concomitant symptoms than placebo; and (3) is well accepted by the patientsin the wafer form.
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- 1988
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27. Ver�nderungen der Hirndurchblutung nach Exstirpation des Glomus caroticum und Denervierung des Sinus caroticum
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M Sastre and R Vara
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Denervation ,medicine.anatomical_structure ,business.industry ,Drug Discovery ,Carotid sinus ,Glomus caroticum ,Molecular Medicine ,Medicine ,General Medicine ,Anatomy ,business ,Genetics (clinical) - Published
- 1961
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28. Preventive treatment of migraine headache with a new isoergolenyl derivative
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W M, Herrmann, M, Kristof, and M, Sastre
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Drug ,media_common.quotation_subject ,Migraine Disorders ,030204 cardiovascular system & hematology ,Pharmacology ,Placebo ,Biochemistry ,Placebos ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,Double-Blind Method ,medicine ,Humans ,Ergolines ,Lisuride ,media_common ,Clinical Trials as Topic ,business.industry ,Hydrogen maleate ,Biochemistry (medical) ,Dopaminergic ,Cell Biology ,General Medicine ,medicine.disease ,Clinical trial ,Migraine ,chemistry ,030220 oncology & carcinogenesis ,business ,Derivative (chemistry) ,medicine.drug - Abstract
In the present double-blind clinical trial an isoergolenyl derivative with periphal antiserotonin, central dopaminergic activity and a-increasing effect on the human EEG, lisuride hydrogen maleate, was tested against placebo in a six-month trial involving 240 patients. Lisuride in long-term administration significantly reduces the frequency of migraine attacks in comparison to placebo. Its advantages are good tolerance and minimal side-effects. It is therefore concluded that lisuride is a suitable and effective drug for the prevention of migraine.
- Published
- 1978
29. Comparative efficacy of lormetazepam (Noctamid) and diazepam (Valium) in 100 out-patients with insomnia
- Author
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M. Sastre y Hernández, K. Fichte, and H.-D. Hentschel
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Adult ,Male ,030204 cardiovascular system & hematology ,Lorazepam ,Biochemistry ,Out patients ,law.invention ,03 medical and health sciences ,Benzodiazepines ,0302 clinical medicine ,Randomized controlled trial ,Double-Blind Method ,law ,Sleep Initiation and Maintenance Disorders ,Insomnia ,Medicine ,Humans ,Aged ,Clinical Trials as Topic ,Diazepam ,business.industry ,Biochemistry (medical) ,Cell Biology ,General Medicine ,Lormetazepam ,Middle Aged ,Anti-Anxiety Agents ,030220 oncology & carcinogenesis ,Concomitant ,Anesthesia ,Female ,medicine.symptom ,business ,medicine.drug - Abstract
Lormetazepam (Noctamid®) at a dosage of 1 mg was compared with diazepam (Valium®) at a dosage of 5 mg in a 7-day double-blind study. The study involved fifty patients in the lormetazepam group and fifty patients in the diazepam group. All the patients were suffering from sleep disorders as a concomitant symptom of general diseases. Lormetazepam was significantly better than diazepam in the: Reduction of the time taken to fall asleep (p < 0.05) Prolongation of the duration of uninterrupted sleep (p < 0.05) Reduction of the frequency of awakening (p < 0.05) Lormetazepam displayed no hang-over effects or other side-effects and, in this respect too, was significantly superior to diazepam (p < 0.05).
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- 1981
30. PRS45 CLINICAL AND ECONOMIC OUTCOME OF MECHANICALLY VENTILATED PATIENTS UNDER DRG 475: A POPULATION-BASED STUDY
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M Sastre, T Lopez, and Carmen Bouza
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Population based study ,medicine.medical_specialty ,business.industry ,Health Policy ,Public Health, Environmental and Occupational Health ,Medicine ,business ,Intensive care medicine ,Outcome (game theory) - Full Text
- View/download PDF
31. CSF Chitinase 3–Like 2 Is Associated With Long-term Disability Progression in Patients With Progressive Multiple Sclerosis
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Sara Llufriu, Albert Saiz, Luisa M. Villar, Eva Borràs, Antonio J. Sánchez López, Manuel Comabella, Sergio Martínez-Yélamos, Eduard Sabidó, J.A. García-Merino, Rucsanda Pinteac, Lucienne Costa-Frossard, Yolanda Blanco, Xavier Montalban, Jaume Sastre-Garriga, Angela Vidal-Jordana, Nicolás Fissolo, Institut Català de la Salut, [Comabella M, Sastre-Garriga J, Pinteac R, Fissolo N, Vidal-Jordana A, Montalban X] Unitat de Neuroimmunologia Clínica, Vall d’Hebron Hospital Universitari, Barcelona, Spain. [Borras E] Proteomics Unit, Universitat Pompeu Fabra, Barcelona. [Villar LM] Departments of Neurology and Immunology, Hospital Universitario Ramon y Cajal, Instituto Ramón y Cajal de Investigación Sanitaria, Madrid. [Saiz A] Service of Neurology, Hospital Clinic and Institut d’Investigacions Biomèdiques August Pi Sunyer, University of Barcelona. [Martínez-Yélamos S] Department of Neurology, Bellvitge University Hospital, Barcelona, and Vall d'Hebron Barcelona Hospital Campus
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Adult ,Male ,Oncology ,medicine.medical_specialty ,Enzymes and Coenzymes::Enzymes::Hydrolases::Glycoside Hydrolases::Chitinases [CHEMICALS AND DRUGS] ,enfermedades del sistema nervioso::enfermedades autoinmunitarias del sistema nervioso::enfermedades autoinmunes desmielinizantes del SNC::esclerosis múltiple::esclerosis múltiple crónica progresiva [ENFERMEDADES] ,Esclerosi múltiple ,Article ,Multiple sclerosis ,Glicosidases ,Nervous System Diseases::Autoimmune Diseases of the Nervous System::Demyelinating Autoimmune Diseases, CNS::Multiple Sclerosis::Multiple Sclerosis, Chronic Progressive [DISEASES] ,Internal medicine ,Cathepsin L1 ,medicine ,Humans ,Pathological Conditions, Signs and Symptoms::Pathologic Processes::Disease Attributes::Disease Progression [DISEASES] ,enzimas y coenzimas::enzimas::hidrolasas::glicósido hidrolasas::quitinasas [COMPUESTOS QUÍMICOS Y DROGAS] ,Shotgun proteomics ,CSF albumin ,biology ,business.industry ,Chitinases ,Biochemical markers ,Patient Acuity ,Area under the curve ,Middle Aged ,Multiple Sclerosis, Chronic Progressive ,Prognosis ,Esclerosi múltiple - Prognosi ,afecciones patológicas, signos y síntomas::procesos patológicos::atributos de la enfermedad::progresión de la enfermedad [ENFERMEDADES] ,Clinical trial ,Neurology ,Estudi de casos ,Chitinase ,Cohort ,Marcadors bioquímics ,Disease Progression ,biology.protein ,Biomarker (medicine) ,Female ,Neurology (clinical) ,Case studies ,business ,Biomarkers ,Follow-Up Studies - Abstract
ObjectiveThis study aimed to identify long-term prognostic protein biomarkers associated with disease progression in patients with progressive multiple sclerosis (MS).MethodsCSF samples were collected from a discovery cohort of 28 patients with progressive MS who participated in a clinical trial with interferon beta. Patients were classified into high and low disability progression phenotypes according to numeric progression rates (NPR) and step-based progression rates (SPR) after a mean follow-up time of 12 years. Protein abundance was measured by shotgun proteomics. Selected proteins from the discovery cohort were quantified by parallel reaction monitoring in CSF samples from an independent validation cohort of 41 patients with progressive MS classified also into high and low disability progression phenotypes after a mean follow-up time of 7 years.ResultsOf 2,548 CSF proteins identified in the discovery cohort, 10 were selected for validation based on their association with long-term disability progression: SPATS2-like protein, chitinase 3–like 2 (CHI3L2), plasma serine protease inhibitor, metallothionein-3, phospholipase D4, beta-hexosaminidase, neurexophilin-1, adipocyte enhancer-binding protein 1, cathepsin L1, and lipopolysaccharide-binding protein. Only CHI3L2 was validated, and patients with high disability progression exhibited significantly higher CSF protein levels compared with patients with low disability progression (p = 0.03 for NPR and p = 0.02 for SPR). CHI3L2 levels showed good performance to discriminate between high and low disability progression in patients with progressive MS (area under the curve 0.73; sensitivity 90% and specificity 63%).ConclusionsAlthough further confirmatory studies are needed, we propose CSF CHI3L2 as a prognostic protein biomarker associated with long-term disability progression in patients with progressive MS.Classification of EvidenceThis study provides Class II evidence that high CSF CHI3L2 levels identified higher disability progression in patients with progressive MS.
- Published
- 2021
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