1. Five fraction stereotactic radiotherapy after brain metastasectomy: a single-institution experience and literature review
- Author
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S. Gomez Ordonez, Susanne Rogers, A. Stauffer, M. Brendel, N. Lomax, S. Alonso, T. Lazeroms, Oliver Riesterer, Brigitte Eberle, L. Schwyzer, E. Kessler, University of Zurich, and Rogers, S
- Subjects
Cancer Research ,medicine.medical_specialty ,medicine.medical_treatment ,610 Medicine & health ,Radiosurgery ,Stereotactic radiotherapy ,10180 Clinic for Neurosurgery ,Meningeal Neoplasms ,medicine ,Humans ,1306 Cancer Research ,Fraction (mathematics) ,Single institution ,Radiation Injuries ,Retrospective Studies ,Brain Neoplasms ,business.industry ,Incidence (epidemiology) ,Metastasectomy ,Brain ,Rate control ,Radiation therapy ,2728 Neurology (clinical) ,Treatment Outcome ,Neurology ,Oncology ,2808 Neurology ,2730 Oncology ,Radiation Dose Hypofractionation ,Neurology (clinical) ,Radiology ,business - Abstract
The outcomes of five fraction stereotactic radiotherapy (hfSRT) following brain metastasectomy were evaluated and compared with published series. 30 Gy in 5 fractions HfSRT prescribed to the surgical cavity was reduced to 25 Gy if the volume of ‘brain−GTV’ receiving 20 Gy exceeded 20 cm3. Endpoints were local recurrence, nodular leptomeningeal recurrence, new brain metastases and radionecrosis. The literature was searched for reports of clinical and dosimetric outcomes following postoperative hfSRT in 3–5 fractions. 39 patients with 40 surgical cavities were analyzed. Cavity local control rate at 1 year was 33/40 (82.5%). 3 local failures followed 30 Gy/5 fractions and 4 with 25 Gy/5 fractions. The incidence of leptomeningeal disease (LMD) was 7/40 (17.5%). No grade 3–4 toxicities, particularly no radionecrosis, were reported. The incidence of distant brain metastases was 15/40 (37.5%). The median overall survival was 15 months. Across 13 published series, the weighted mean local control was 83.1% (adjusted for sample size), the mean incidence of LMD was 14.9% (7–34%) and the mean rate of radionecrosis was 10.3% (0–20.6%). Postoperative hfSRT can be delivered with 25–30 Gy in 5 fractions with efficacy in excess of 82% and no significant toxicity when the dose to ‘brain−GTV’ does not exceed 20 cm3.
- Published
- 2021