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3 results on '"Louise Gontard"'

1. High severe acute respiratory coronavirus virus 2 (SARS-CoV-2) seroconversion rate among geriatric staff from Strasbourg University Hospitals

Author

Sabrina Kepka, Thierry Lavigne, Aurélie Velay, Yasmine Sammour, Georges Kaltenbach, Maxence Meyer, Baptiste Panaget, Floriane Gallais, María González, Jean-Marc Lessinger, Céline Hernandez, Elisabeth Antoni, Marie-Josée Wendling, Laurence Kling-Pillitteri, Yves Hansmann, François Severac, Samira Fafi-Kremer, and Louise Gontard

Subjects
Microbiology (medical), 2019-20 coronavirus outbreak, Coronavirus disease 2019 (COVID-19), Epidemiology, business.industry, Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), University hospital, medicine.disease_cause, Virology, Virus, Infectious Diseases, medicine, Seroconversion, Respiratory system, business, Letter to the Editor, Coronavirus
Published
2021

2. In‐depth virological assessment of kidney transplant recipients with COVID‐19

Author

Aurélie Velay, Clement Baldacini, Noëlle Cognard, Ilies Benotmane, Louise Gontard, Margaux Della-Chiesa, Samira Fafi-Kremer, Dogan Firat Bozman, Floriane Gallais, Marie Josée Wendling, Heloise Delagreverie, Dimitri Bedo, Sophie Caillard, Gabriela Gautier-Vargas, Bruno Moulin, Francoise Heibel, Laura Braun-Parvez, Morgane Solis, Mylene Sagnard, Jérôme Olagne, David Marx, Xavier Bassand, Baptiste Panaget, and Peggy Perrin

Subjects
Male, medicine.medical_specialty, Coronavirus disease 2019 (COVID-19), Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), viruses, Enzyme-Linked Immunosorbent Assay, Comorbidity, 030230 surgery, Brief Communication, Antibodies, Viral, Gastroenterology, Kidney transplant, Serology, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, Nasopharynx, medicine, Immunology and Allergy, Humans, Pharmacology (medical), Viral shedding, Pandemics, Aged, Transplantation, biology, business.industry, SARS-CoV-2, COVID-19, Middle Aged, Viral Load, Kidney Transplantation, Survival Rate, medicine.anatomical_structure, biology.protein, Female, France, Antibody, business, Viral load, Respiratory tract
Abstract

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has spread widely, causing coronavirus disease 2019 (COVID-19) and significant mortality. However, data on viral loads and antibody kinetics in immunocompromised populations are lacking. We aimed to determine nasopharyngeal and plasma viral loads via reverse transcription-polymerase chain reaction and SARS-CoV-2 serology via enzyme-linked immunosorbent assay and study their association with severe forms of COVID-19 and death in kidney transplant recipients. In this study, we examined hospitalized kidney transplant recipients with nonsevere (n = 21) and severe (n = 19) COVID-19. SARS-CoV-2 nasopharyngeal and plasma viral load and serological response were evaluated based on outcomes and disease severity. Ten recipients (25%) displayed persistent viral shedding 30 days after symptom onset. The SARS-CoV-2 viral load of the upper respiratory tract was not associated with severe COVID-19, whereas the plasma viral load was associated with COVID-19 severity (P = .010) and mortality (P = .010). All patients harbored antibodies during the second week after symptom onset that persisted for 2 months. We conclude that plasma viral load is associated with COVID-19 morbidity and mortality, whereas nasopharyngeal viral load is not. SARS-CoV-2 shedding is prolonged in kidney transplant recipients and the humoral response to SARS-CoV-2 does not show significant impairment in this series of transplant recipients.

Published
2020

3. In-depth virological assessment of kidney transplant recipients with COVID-19

Author

Morgane Solis, Baptiste Panaget, Clement Baldacini, Mylene Sagnard, Ilies Benotmane, Dogan-Firat Bozman, Francoise Heibel, Gabriela Gautier Vargas, Samira Fafi-Kremer, Louise Gontard, Noëlle Cognard, Laura Braun, B. Moulin, Heloise Delagreverie, Dimitri Bedo, Margaux Della Chiesa, Aurélie Velay, Jérôme Olagne, David Marx, Peggy Perrin, Floriane Gallais, Xavier Bassand, Marie-Josée Wendling, and Sophie Caillard

Subjects
medicine.medical_specialty, Coronavirus disease 2019 (COVID-19), biology, business.industry, viruses, Kidney transplant, Gastroenterology, Serology, medicine.anatomical_structure, Disease severity, Internal medicine, medicine, biology.protein, Viral shedding, Antibody, business, Viral load, Respiratory tract
Abstract

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has spread widely, causing coronavirus disease 2019 (COVID-19) and significant mortality. However, data on viral loads and antibody kinetics in immunocompromised populations are lacking. We aimed to determine nasopharyngeal and plasma viral loads via RT-PCR and SARS-CoV-2 serology via ELISA and study their association with severe forms of COVID-19 and death in kidney transplant recipients. In this study we examined hospitalized kidney transplant recipients with non-severe (n = 21) and severe (n =19) COVID-19. SARS-CoV-2 nasopharyngeal and plasma viral load and serological response were evaluated based on outcomes and disease severity. Ten recipients (25%) displayed persistent viral shedding 30 days after symptom onset. The SARS-CoV-2 viral load of the upper respiratory tract was not associated with severe COVID-19, whereas the plasma viral load was associated with COVID-19 severity (p=0.0087) and mortality (p=0.024). All patients harbored antibodies the second week after symptom onset that persisted for two months. We conclude that plasma viral load is associated with COVID-19 morbidity and mortality, whereas nasopharyngeal viral load is not. SARS-CoV-2 shedding is prolonged in kidney transplant recipients and the humoral response to SARS-CoV-2 does not show significant impairment in this series of transplant recipients.

Published
2020

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