18 results on '"Ling, Dan"'
Search Results
2. Crystal Violet-Sensitized Direct Z-Scheme Heterojunction Coupled with a G-Wire Superstructure for Photoelectrochemical Sensing of Uracil-DNA Glycosylase
- Author
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Yu Ling, Ling Dan Yu, Nian Bing Li, Hong Qun Luo, Xing Yue Zhang, Xiao Hu Wang, and Lei Han
- Subjects
Materials science ,02 engineering and technology ,Biosensing Techniques ,Conjugated system ,Sulfides ,010402 general chemistry ,01 natural sciences ,Signal ,Tungsten ,chemistry.chemical_compound ,Humans ,General Materials Science ,Crystal violet ,Coloring Agents ,Uracil-DNA Glycosidase ,Enzyme Assays ,Superstructure ,business.industry ,Tin Compounds ,Heterojunction ,Oxides ,Electrochemical Techniques ,021001 nanoscience & nanotechnology ,0104 chemical sciences ,Nanostructures ,chemistry ,Excited state ,Optoelectronics ,Gentian Violet ,0210 nano-technology ,business ,Biosensor ,Visible spectrum ,HeLa Cells - Abstract
Dye sensitization achieving photoelectrochemical (PEC) signal amplification for ultrasensitive bioanalysis has undergone a major breakthrough. In this proposal, an innovative PEC sensing platform is developed by combining Z-scheme WO3@SnS2 photoactive materials and a G-wire superstructure as well as a dye sensitization enhancement strategy. The newly synthesized WO3@SnS2 heterojunction with outstanding PEC performance is employed as a photoelectrode matrix. Due to the formation of the Z-scheme heterojunction between WO3 and SnS2, the migration dynamics of the photogenerated carrier is evidently augmented. To improve sensitivity, the target excision-driven dual-cycle signal amplification strategy is introduced to output exponential c-myc fragments. Crystal violet is then conjugated into the G-quadruplex to amplify the PEC signal, where crystal violet generates excited electrons by capturing visible light and rapidly injects electrons into the conduction band of SnS2, suppressing the recombination of the photo-induced carrier. Moreover, the G-wire superstructure acts as a universal amplification pathway, ensuring adequate crystal violet loads. Specifically, the biosensor for uracil-DNA glycosylase quantification displays a wide detection range (0.0005-1.0 U/mL) and a lower detection limit (0.00025 U/mL). Furthermore, the Z-scheme electron migration mechanism and the crystal violet sensitization effect are discussed in detail. The construction of the PEC sensor provides a new consideration for signal amplification and material design.
- Published
- 2021
3. Artesunate inhibits the development of PVR by suppressing the TGF-β/Smad signaling pathway
- Author
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Ling-Dan Wu, Zi-Yi Wang, Qi-Hua Xu, Ci-Min Chen, Jie Chen, Mei-Ling Chen, and Yu Zhang
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Proliferative vitreoretinopathy ,Epithelial-Mesenchymal Transition ,Contraction (grammar) ,medicine.medical_treatment ,Blotting, Western ,Artesunate ,Enzyme-Linked Immunosorbent Assay ,Retinal Pigment Epithelium ,Cell Line ,Antimalarials ,Transforming Growth Factor beta2 ,Cellular and Molecular Neuroscience ,chemistry.chemical_compound ,Cell Movement ,In vivo ,medicine ,Animals ,Humans ,Smad3 Protein ,Epithelial–mesenchymal transition ,Autocrine signalling ,business.industry ,Growth factor ,Cell Cycle ,Vitreoretinopathy, Proliferative ,Flow Cytometry ,medicine.disease ,eye diseases ,Sensory Systems ,Ophthalmology ,chemistry ,Intravitreal Injections ,Cancer research ,Rabbits ,business ,Signal Transduction ,Transforming growth factor - Abstract
Proliferative vitreoretinopathy (PVR) is the main cause of retinal detachment surgery failure. The epithelial-mesenchymal transition (EMT) induced by transforming growth factor (TGF-β2) plays an important role in the development of PVR. Artesunate has been widely studied as a treatment for ophthalmic diseases because of its antioxidant, anti-inflammatory, antiapoptotic and antiproliferative properties. The purpose of this study was to investigate the effects of artesunate on the TGF-β2-induced EMT in ARPE-19 cells and PVR development. We found that artesunate inhibited the proliferation and contraction of ARPE-19 cells after the EMT and the autocrine effects of TGF-β2 on ARPE-19 cells. Additionally, the levels of Smad3 and p-Smad3 were increased in clinical samples, and artesunate decreased the levels of Smad3 and p-Smad3 in ARPE-19 cells treated with TGF-β2. Artesunate also inhibited the occurrence and development of PVR in vivo. In summary, artesunate inhibits the occurrence and development of PVR by inhibiting the EMT in ARPE-19 cells.
- Published
- 2021
4. The genes associated with early-onset Alzheimer’s disease
- Author
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Hui Zheng, Meng-Hui Dai, Ling-Dan Zeng, and Yan Zhang
- Subjects
0301 basic medicine ,Amyloid beta ,Disease ,Review ,03 medical and health sciences ,0302 clinical medicine ,Genetic linkage ,PSEN2 ,PSEN1 ,Medicine ,Dementia ,Early-onset Alzheimer's disease ,Genetics ,biology ,business.industry ,Neurodegeneration ,medicine.disease ,early-onset AD ,030104 developmental biology ,Oncology ,biology.protein ,business ,APP ,Alzheimer’s disease ,030217 neurology & neurosurgery - Abstract
Alzheimer's disease (AD) is a progressive neurodegenerative disorder that accounts for the most cases of dementia, which is characterized by the deposition of dense plaques of amyloid beta (Aβ) plaques and neurofibrillary tangles consisting of hyperphosphorylated tau. The two main types of AD can be classified as early-onset AD (EOAD, onset < 65 years) and late-onset AD (LOAD, onset ≥ 65 years). Evidence from family and twin studies indicate that genetic factors are estimated to play a role in at least 80% of AD cases. The first milestone with linkage analysis revealed the mutations in APP, PSEN1, and PSEN2 genes that cause EOAD. But pathogenic mutations in these three genes can only explain a small fraction of EOAD families. The additional disease-causing genes have not yet been identified. This review provides an overview of the genetic basis of EOAD and the relationship between the functions of these risk genes and the neuropathologic features of AD. A better understanding of genetic mechanisms underlying EOAD pathogenesis and the potentially molecular mechanisms of neurodegeneration will lead to the development of effective diagnosis and treatment strategies for this devastating disease.
- Published
- 2017
5. Evaluation of Long-Term Impact of Pericardiectomy on Left Atrial Functions in Patients with Constrictive Pericarditis Using Speckle Tracking Echocardiography
- Author
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Jun Zhang, Kun Liu, You-bin Deng, Qiao-ying Tang, Ling-Dan Guo, and Li Li
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Constrictive pericarditis ,Adult ,Male ,medicine.medical_specialty ,Acoustics and Ultrasonics ,Longitudinal strain ,medicine.medical_treatment ,Heart Ventricles ,Biophysics ,Speckle tracking echocardiography ,030204 cardiovascular system & hematology ,Ventricular Function, Left ,03 medical and health sciences ,Young Adult ,0302 clinical medicine ,Left atrial ,Internal medicine ,Healthy volunteers ,medicine ,Humans ,Radiology, Nuclear Medicine and imaging ,In patient ,Prospective Studies ,Pericardiectomy ,Radiological and Ultrasound Technology ,business.industry ,Pericarditis, Constrictive ,Reproducibility of Results ,Middle Aged ,medicine.disease ,Echocardiography, Doppler ,030228 respiratory system ,Left Atrial Functions ,Cardiology ,Female ,business ,Follow-Up Studies - Abstract
The aims of this study were to explore the long-term impact of pericardiectomy on left atrial (LA) functions in patients with constrictive pericarditis (CP) using speckle tracking echocardiography (STE) and to correlate post-operative LA functions with clinical status. Echocardiographic examinations were undertaken in 29 patients with CP 1 wk before and 1, 6 and 12 mo after pericardiectomy. STE was performed to obtain LA global longitudinal strain, including strain during the conduit phase (LAScd), strain during the contraction phase (LASct) the sum of the latter and strain during the reservoir phase (LASr). Control patients consisted of 29 age- and sex-matched healthy volunteers. LASct, LAScd and LASr obtained 6 mo after pericardiectomy improved significantly compared with pre-operative values, but were still lower than the values for control patients. Further increases were observed gradually with normalization of LASct 12 mo after pericardiectomy. However, there were still significant differences between LAScd and LASr obtained in control patients and those obtained 12 mo after pericardiectomy. Moreover, the improvements in LAScd, LASct and LASr 12 mo after pericardiectomy correlated well with symptomatic clinical alleviation (p0.01). These results indicate that LA strains analyzed with STE might be useful in evaluating the long-term impact of pericardiectomy on LA functions.
- Published
- 2019
6. Value chain reconstruction and sustainable development of green manufacturing industry
- Author
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Liu Huiling and Ling Dan
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Sustainable development ,Organizational architecture ,General Computer Science ,business.industry ,Computer science ,020209 energy ,020206 networking & telecommunications ,02 engineering and technology ,Green manufacturing ,Chain (unit) ,Competition (economics) ,Manufacturing ,Value (economics) ,0202 electrical engineering, electronic engineering, information engineering ,Enterprise theory ,Electrical and Electronic Engineering ,business ,Industrial organization - Abstract
In recent years, sustainable development has become the goal pursued by all mankind. In such an era, the concept of green manufacturing industry has been put forward. While manufacturing industry gains rapid development by taking advantage of this opportunity, it also faces greater competition. Sustainable development is a "double-edged sword" for the manufacturing industry. It not only brings unlimited opportunities for the long-term development of the manufacturing industry, but also makes the strategic operation of the manufacturing industry full of unpredictable risks. The main purpose of this study is how to carry out green innovation from the strategic level for the manufacturing enterprises in this revolution. This study integrated application of green sustainable development theory, enterprise theory and enterprise strategic innovation theory, combining the particularity of manufacturing enterprise, from manufacturing enterprise strategic operating level, the system of manufacturing enterprise for sustainable development opportunity and risk, environmental competitiveness assessment, the green value chain innovation, green organizational design, and performance evaluation of green and so on, to guide our manufacturing enterprises how to abandon the traditional energy-intensive, highly polluting manufacturing enterprise management mode, to somewhere in the world, every year rose nearly 76 % of manufacturing output in terms of our country, It is of great practical significance to carry out green strategy innovation in manufacturing enterprises.
- Published
- 2020
7. Usefulness of Contrast Perfusion Echocardiography for Differential Diagnosis of Cardiac Masses
- Author
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Wen-xuan Wang, Yani Liu, Li Li, You-bin Deng, Hongyun Liu, Wei Zhou, Qiao-ying Tang, and Ling-Dan Guo
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Adult ,Male ,medicine.medical_specialty ,Adolescent ,Acoustics and Ultrasonics ,media_common.quotation_subject ,Biophysics ,Contrast Media ,Sensitivity and Specificity ,Benign tumor ,Diagnosis, Differential ,Heart Neoplasms ,Young Adult ,medicine ,Humans ,Contrast (vision) ,Radiology, Nuclear Medicine and imaging ,Thrombus ,Child ,Aged ,media_common ,Aged, 80 and over ,Observer Variation ,Radiological and Ultrasound Technology ,business.industry ,Myocardial Perfusion Imaging ,Curve analysis ,Reproducibility of Results ,Thrombosis ,Middle Aged ,Image Enhancement ,medicine.disease ,Intensity (physics) ,Validation methods ,Echocardiography ,cardiovascular system ,Female ,Radiology ,Differential diagnosis ,business ,Perfusion - Abstract
The aim of this study was to assess the usefulness of contrast perfusion echocardiography in the differential diagnosis of different types of cardiac masses. Conventional echocardiography and contrast perfusion echocardiography were performed in 72 patients with cardiac masses. The degree of contrast enhancement of the mass and an adjacent section of myocardium after injection of contrast agent was determined by visual inspection and quantitative time–signal intensity curve analysis. The difference in maximal steady-state pixel intensity between the mass and the adjacent myocardium (Δ A mass–myocardium ) was calculated. All masses had a pathologic diagnosis or resolved after anticoagulation. All 16 cardiac masses without enhancement on visual inspection were confirmed to be cardiac thrombi. Twenty-four masses with incomplete enhancement on visual inspection were recognized as benign tumors with validation methods. Of the 32 cardiac masses with complete enhancement, 30 were confirmed as malignant tumors and two as benign tumors with validation methods. The sensitivity and specificity of Δ A mass–myocardium in differentiating thrombi from tumors were 93% and 100%, respectively, and 100% and 97% in differentiating malignant tumors from benign tumors and thrombi. Both visual and quantitative assessment of degree of enhancement of cardiac masses in relation to the adjacent myocardium during contrast perfusion echocardiography had high diagnostic accuracy for differentiation of a thrombus from a tumor or a benign tumor from a malignant tumor.
- Published
- 2015
8. Alkaloids of Nitraria sibirica Pall. decrease hypertension and albuminuria in angiotensin II-salt hypertension
- Author
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Mong Heng Wang, Mahinur Bakri, Haji Akber Aisa, Ling-Dan Chen, and Yi Yang
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Male ,medicine.medical_specialty ,Blood Pressure ,Rats, Sprague-Dawley ,Excretion ,Magnoliopsida ,Mice ,Alkaloids ,Fibrosis ,Internal medicine ,Drug Discovery ,Renal fibrosis ,Albuminuria ,Animals ,Humans ,Medicine ,Sodium Chloride, Dietary ,Chemokine CCL2 ,business.industry ,Angiotensin II ,Monocyte ,General Medicine ,medicine.disease ,Endocrinology ,Blood pressure ,medicine.anatomical_structure ,Complementary and alternative medicine ,Nitraria sibirica ,Hypertension ,medicine.symptom ,business ,Drugs, Chinese Herbal - Abstract
In traditional Chinese medicine, Nitraria sibirica Pall. (Nitrariaceae) is used to treat hypertension. This study determined the effects of the total alkaloids of the leaves of Nitraria sibirica (NSTA) on blood pressure and albuminuria in mice treated with angiotensin II and a high-salt diet (ANG/HS). Adult mice were divided into three groups: control; infused with angiotensin II and fed a diet containing 4% NaCl (ANG/HS; and ANG/HS plus injection of NSTA (1 mg·kg(-1)·d(-1), i.p.). After treatment of these regimens, daily water and food intake, kidney weight, blood pressure, urinary albumin excretion, renal concentrations of inflammatory markers, including soluble intercellular adhesion molecule-1 (sICAM-1) and monocyte chemoattractant protein-1 (MCP-1), and the expression of renal fibrosis markers were determined. Compared to the control group, the ANG/HS group had higher blood pressure and urinary albumin excretion. Treatment with NSTA in ANG/HS mice for three weeks significantly reduced blood pressure and urinary albumin excretion. ANG/HS treatment caused elevated levels of sICAM-1 and MCP-1, as well as increased fibrosis markers. Concurrent treatment with ANG/HS and NSTA attenuated the levels and expression of renal inflammatory and fibrosis markers. Treatment with NSTA effectively reduces hypertension-induced albuminuria through the reduction of renal inflammatory and fibrosis markers.
- Published
- 2014
9. Research on the Competitive Power of Coal Enterprises of China based on the Technology Efficiency
- Author
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YU Shihai, Ling Dan, and Wang Hongguo
- Subjects
Power (social and political) ,Computer Networks and Communications ,Computer science ,business.industry ,Coal ,Industry of China ,business ,China ,Software ,Industrial organization - Published
- 2012
10. on the Comparative Advantage of China's Auto Engineering Industry
- Author
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Zhao Chunyan, Ling Dan, and Wang Shuli
- Subjects
China's Auto Engineering ,Government ,Principal Component Analysis ,business.industry ,the Comparative Advantage ,International trade ,Human capital ,Economies of scale ,ComputingMilieux_GENERAL ,Product (business) ,Market structure ,Engineering industry ,Business ,China ,Evaluation ,Industrial organization ,Comparative advantage - Abstract
The industry of auto engineering becomes one important mainstay industry to Chinese economy along with market economic development. This paper employs the principal components analysis with the SPSS19.0 statistical analysis software to evaluate comparative advantage of China's auto industry. It presents the evaluation indexes, including the market structure, economies of scale, product heterogeneity, related industries, technology, resources, human capital and organization. The conclusions are drawn as follows: The trend of comparative advantage of China's Auto industry gradually increased from 1998 to 2009, which from minus 0.05 to 0.86, almost increased by nearly 16 times. Meanwhile, technology, logistics and comprehensive factor become the core three factors to comparative advantage of China's auto industry. Therefore, to improve the comparative advantage of China's auto industry, both the relevant enterprises and the government should take effective measures to inspirit and maximum these useful factors.
- Published
- 2012
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11. Long-Term Effects of Pericardiectomy on Left Ventricular Mechanics Evaluated by Using Speckle Tracking Echocardiography in Patients with Constrictive Pericarditis
- Author
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Qiao-ying Tang, Ling-Dan Guo, Wei Zhou, Hongyun Liu, Li Li, Kun Liu, and You-bin Deng
- Subjects
Constrictive pericarditis ,Adult ,Male ,medicine.medical_specialty ,Acoustics and Ultrasonics ,medicine.medical_treatment ,Treatment outcome ,Biophysics ,Speckle tracking echocardiography ,030204 cardiovascular system & hematology ,Sensitivity and Specificity ,03 medical and health sciences ,Ventricular Dysfunction, Left ,0302 clinical medicine ,Internal medicine ,Elastic Modulus ,Healthy volunteers ,medicine ,Circumferential strain ,Humans ,Radiology, Nuclear Medicine and imaging ,In patient ,030212 general & internal medicine ,Longitudinal Studies ,Pericardiectomy ,Ventricular mechanics ,Radiological and Ultrasound Technology ,business.industry ,Pericarditis, Constrictive ,Reproducibility of Results ,Middle Aged ,medicine.disease ,Treatment Outcome ,Echocardiography ,Cardiology ,Elasticity Imaging Techniques ,Female ,Radiology ,business - Abstract
The aim of this study was to evaluate long-term changes in left ventricular (LV) mechanics after pericardiectomy in patients with constrictive pericarditis (CP) and to correlate post-operative LV mechanics with clinical status. A total of 24 patients with CP underwent serial speckle tracking echocardiography 1 wk before and 1, 6 and 12 mo after pericardiectomy. Global LV longitudinal, circumferential and radial strains, along with LV twist, were measured. Twenty-three healthy volunteers were served as control patients. Although global LV longitudinal, circumferential and radial strains obtained 6 mo after pericardiectomy increased compared with those for pre-pericardiectomy, they were still significantly lower than those for control patients. Further improvements occurred over time with normalization of global LV longitudinal and radial strains 12 mo after pericardiectomy, but global circumferential strain obtained 12 mo after pericardiectomy was still lower than that for control patients. LV twist remained unchanged after pericardiectomy. In addition, the improvements in global LV circumferential strain after pericardiectomy were associated with improvements in clinical symptoms (p
- Published
- 2015
12. Effect of early intervention on premature infants' general movements
- Author
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Baohong Wang, Liang Ma, Ling-Dan Meng, Chun-Hui Zheng, Bingshang Yang, and Ai-Hua Cao
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Pediatrics ,medicine.medical_specialty ,Gymnastics ,Birth weight ,Movement ,Video Recording ,Gestational Age ,Intervention group ,Child Development ,Developmental Neuroscience ,Intervention (counseling) ,Physical Stimulation ,Medicine ,Birth Weight ,Humans ,Hydrotherapy ,business.industry ,Significant difference ,Rehabilitation ,Infant, Newborn ,Gestational age ,Infant ,General Medicine ,General movements ,Pediatrics, Perinatology and Child Health ,Fidgety movements ,Infant Care ,Neurology (clinical) ,business ,Infant, Premature - Abstract
This study is to investigate the characteristics of premature infants' general movements (GMs) and the effect of early intervention on their GMs.The survey was carried among 285 premature infants. (1) Before intervention, the correlation between the gestational age/ birth weight and the GMs was evaluated. (2) The cases were divided into early intervention group (n=145) and control group (n=140), each group was divided into32 weeks, 32-34 weeks and34 weeks group according to gestational age. The early intervention was begun at the 3rd day after birth to 54th week gestational age. The rate of GMs among each group was compared after intervention.(1) Before intervention, gestational age/birth weight was negatively correlated with the rate of cramped-synchronized (CS) (r=-0.988, r=-0.95, p0.01), while no correlation with the rate of poor repertoire (PR) (r=0.122, r=0.168, p0.05). (2) After intervention, for the writhing movement, there was no significant difference (χ2=0.509, 1.401, 0.519, p0.05) between the early intervention group and the control group. Nevertheless, for the fidgety movement, there was significant difference (χ2=7.921, χ2=5.763, p0.05) between the two groups, especially in32 weeks group (χ2=5.578, 4.067 p0.05) and in34 weeks group (χ2=5.757, p0.05).(1) It shows that the lower birth weight or the younger delivery gestational age, the more abnormal GMs in premature infants. (2) Early intervention could improve the fidgety movements of premature infant.
- Published
- 2014
13. Regional logistics capability evaluation based on factor analysis-An empirical research on Hubei
- Author
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Ye Xuan, Ling Dan, and Wang Yuejie
- Subjects
Truck ,Empirical research ,Traffic management ,Retail sales ,business.industry ,Fixed investment ,Integrated logistics support ,Operations management ,Business ,Investment (macroeconomics) ,Tertiary sector of the economy ,Industrial organization - Abstract
Combining factor analysis with key components of regional logistics capability, this paper proposes Hubei logistics capability evaluation system and method based on factor analysis in the background of industrial transfer, at the same time constructs the evaluation model of Hubei logistics capability, and finally tries to find the major factors affecting Hubei logistics capability. The result of model shows that the major factors affecting the improvement of Hubei logistics capability are: freight traffic, turnover volume of freight traffic, proportion of the tertiary industry, number of trucks, total retail sales of consumer goods, and fixed investment in the logistics industry.
- Published
- 2011
14. Hematoporphyrin monomethyl ether enhances the killing action of ultrasound on osteosarcoma in vivo
- Author
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Xuemou Quan, Wingnang Leung, Chuanshan Xu, Zedan Tian, Ling Dan, and Hui Guo
- Subjects
Male ,Pathology ,medicine.medical_specialty ,Ultrasonic Therapy ,Rats, Sprague-Dawley ,chemistry.chemical_compound ,In vivo ,Cell Line, Tumor ,Medicine ,Animals ,Humans ,Radiology, Nuclear Medicine and imaging ,Fragmentation (cell biology) ,Osteosarcoma ,Photosensitizing Agents ,Radiological and Ultrasound Technology ,business.industry ,Ultrasound ,medicine.disease ,Staining ,Rats ,Disease Models, Animal ,Hematoporphyrins ,Treatment Outcome ,chemistry ,Apoptosis ,Growth inhibition ,business ,Pyknosis - Abstract
Objectives. Osteosarcoma is one of the most common malignant cancers afflicting young adults. Ultrasound is a new therapeutic modality for controlling malignant cancers. Enhancing the efficacy of ultrasound treatment will improve clinical outcomes. The aim of this study was to investigate the killing action of ultrasound on osteosarcoma enhanced by hematoporphyrin monomethyl ether (HMME) in vivo. Methods. An animal model of an osteosarcoma xenograft was set up to investigate the inhibitory effect of sonoactivating HMME on osteosarcoma. High-performance liquid chromatography was used to analyze the time course of HMME in the osteosarcoma xenograft. Three hours after intravenous (IV) administration of HMME, ultrasound radiation was administered in the osteosarcoma xenograft. On day 7 after ultrasound radiation, the tumor volume and weight were measured and calculated for effect assessment, hematoxylin-eosin staining for histopathologic examination, immunohistochemical staining for proliferating cell nuclear antigen (PCNA) expression, and terminal deoxyuridine nick end-labeling (TUNEL) staining for apoptosis examinations. Results. The peak value of HMME in osteosarcoma tissues increased with time after IV administration of HMME and reached a plateau at 3 hours. The increasing rates of the tumor volume and weight in the control group were very fast, but the increasing rates in the ultrasound-alone group were slower, and those in the ultrasound-HMME group were the slowest throughout the observation period. There was a significant difference between the HMME-ultrasound, ultrasound-alone, and control groups (P < .01). Hematoxylin-eosin staining showed that some cells had typical cell death such as pyknosis and nuclear fragmentation after ultrasound radiation alone. More cells with pyknosis, nuclear fragmentation, and even karyolysis were found after HMME-ultrasound treatment. Immunohistochemical staining showed that the percentage of PCNA-positive cells decreased and that of TUNEL-positive cells increased after ultrasound treatment alone, and the changes in the PCNA- and TUNEL-positive percentages were significantly enhanced by pretreatment with HMME (20 mg/kg, IV) for 3 hours and ultrasound radiation (10.5 MHz) for 120 seconds at an intensity of 0.8 W/cm 2 (P < .05). Conclusions. Hematoporphyrin monomethyl ether pretreatment could substantially enhance the growth inhibition of ultrasound on osteosarcoma, which suggests that HMME is an efficient sonosensitizer, and ultrasound radiation with HMME could be developed as a new modality for treating osteosarcoma.
- Published
- 2009
15. Control of gallbladder contractions by cholecystokinin through cholecystokinin-A receptors on gallbladder interstitial cells of cajal
- Author
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He-Sheng Luo, Ling-Dan Chen, Bao-Ping Yu, and Dan Xu
- Subjects
Atropine ,medicine.medical_specialty ,Cholagogues and Choleretics ,Contraction (grammar) ,Guinea Pigs ,Muscarinic Antagonists ,Tetrodotoxin ,digestive system ,Guinea pig ,symbols.namesake ,chemistry.chemical_compound ,Internal medicine ,medicine ,Animals ,Receptor ,Cells, Cultured ,Cholecystokinin ,Dose-Response Relationship, Drug ,business.industry ,Gallbladder ,digestive, oral, and skin physiology ,Gastroenterology ,Muscle, Smooth ,General Medicine ,Peptide Fragments ,Interstitial cell of Cajal ,Receptor, Cholecystokinin A ,Endocrinology ,medicine.anatomical_structure ,chemistry ,symbols ,medicine.symptom ,business ,hormones, hormone substitutes, and hormone antagonists ,Rapid Communication ,Muscle contraction ,Muscle Contraction ,Sodium Channel Blockers - Abstract
AIM: To identify the cholecystokinin (CCK)-A receptors (CCK-AR) on the guniea pig gallbladder interstitial cells of cajal (ICC) and to study CCK-8 induced gallbladder muscle strip contractions through the CCK-AR. METHODS: The existence of CCK-AR was examined by immunohistofluorescence on sectioned tissue and cultured cells. In vitro contractile response of guinea pig gallbladder muscle strips and the strips with ICC removed were also studied with CCK-8 receptors added. RESULTS: In tissue sections, intensely CCKAR-immunoreactive interstitial cells were found mainly in the muscular layers. In cultured cell sections, distinctive double staining of C-kit and CCK-AR ICCs were found. When we removed the ICC of the gallbladder, CCK-8 induced muscle strip contraction dose response curve significantly shifted to the right. CONCLUSION: We proved that both the existence of CCK-AR on the guinea pig gallbladder ICC and CCK evoked contraction are mediated through direct action on CCK-AR on the gallbladder ICC.
- Published
- 2008
16. A comprehensive method for agility evaluation of dynamic alliance based on certainty factor and fuzzy logic
- Author
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Zhao Jin, Zhuang Wanyu, and Ling Dan
- Subjects
Knowledge management ,business.industry ,Computer science ,Certainty factor ,Inference ,ComputingMilieux_LEGALASPECTSOFCOMPUTING ,Agile manufacturing ,Fuzzy logic ,Alliance ,Fuzzy logic inference ,Fuzzy reasoning ,Artificial intelligence ,business ,Randomness - Abstract
A new method for evaluating the agility of dynamic alliance based on certainty factor inference and fuzzy logic inference is discussed. Using this method, the randomness and fuzziness of evaluation indexes can be expressed and managed entirely. This method will play positive role in seeking alliance partner for the leader of an alliance, and in evaluating the agility of an enterprise to improve itself.
- Published
- 2006
17. The research of domestic enterprise agility index and appraisement model
- Author
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Ling Dan, Zhao Jin, and Zhuang Wanyu
- Subjects
Engineering ,Index (economics) ,Index system ,Risk analysis (engineering) ,business.industry ,Certainty factor ,Enterprise agility ,Agile manufacturing ,Mechatronics ,Robustness (economics) ,business ,Manufacturing engineering ,Environmental index - Abstract
Through expanding environmental index, the Cost-Time-Robustness-Scope-Environment (CTRSE) enterprise agility index system and the uncertainty synthesize appraisement model based on Certainty Factor are presented in this paper, The index system base on Cost-Time-Robustness-Scope (CTRS) was made by RickDove . Considering the practical condition of China, the expanded environmental index and appraisement model were proposed. This system ate never mentioned before and can evaluate the agility index of manufacturing enterprise easily, quickly, and effectively.
- Published
- 2005
18. Estimation of distance on flat and uphill terrains using visual matching and blind walking task
- Author
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Huaiyong Zhao, Peng Wang, Ai-Shi Jiang, Hong-Jin Sun, and Ling-Dan Wu
- Subjects
Estimation ,Ophthalmology ,Computer science ,business.industry ,Computer vision ,Terrain ,Artificial intelligence ,business ,Sensory Systems ,Visual matching ,Task (project management) - Published
- 2010
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