Author: "Lin, Pei" / Topic: business - Searchworks@Jio Institute Digital Library Search Results

79 results on '"Lin, Pei"'

1. Innovative Pre-Preemption Strategies for Traffic Light-Controlled Intersections Adjacent to Railroad Crossings: Pre-preemption strategies keep trains and traffic moving by revolutionizing traffic flow and safety at busy railroad crossings in urban areas

Author: Lin, Pei-Sung and Wang, Zhenyu
Subjects: Traffic safety, Railroads -- Crossings, Business, Transportation industry
Abstract: Navigating busy intersections near railroad crossings can be a significant challenge, especially during rush hour when trains roll through, causing traffic lights to change and cars to back up. But [...]
Published: 2024

2. ICPFuzzer: proprietary communication protocol fuzzing by using machine learning and feedback strategies

Author: Ting-Chun Huang, Chia-Wei Tien, Lin Pei-Yi, and Chin-Wei Tien
Subjects: Computer engineering. Computer hardware, Computer Networks and Communications, Computer science, Smart meter, 02 engineering and technology, 01 natural sciences, Field (computer science), Industrial communication protocol, TK7885-7895, Artificial Intelligence, Industrial control system (ICS), 0202 electrical engineering, electronic engineering, information engineering, Protocol (science), business.industry, 020208 electrical & electronic engineering, 010401 analytical chemistry, Industrial control system, Fuzz testing, QA75.5-76.95, 0104 chemical sciences, Embedded system, Electronic computers. Computer science, Long short-term memory (LSTM), Interrupt, business, Communications protocol, Software, Information Systems, Test data, Network protocol fuzzing
Abstract: The fuzzing test is able to discover various vulnerabilities and has more chances to hit the zero-day targets. And ICS(Industrial control system) is currently facing huge security threats and requires security standards, like ISO 62443, to ensure the quality of the device. However, some industrial proprietary communication protocols can be customized and have complicated structures, the fuzzing system cannot quickly generate test data that adapt to various protocols. It also struggles to define the mutation field without having prior knowledge of the protocols. Therefore, we propose a fuzzing system named ICPFuzzer that uses LSTM(Long short-term memory) to learn the features of a protocol and generates mutated test data automatically. We also use the responses of testing and adjust the weight strategies to further test the device under testing (DUT) to find more data that cause unusual connection status. We verified the effectiveness of the approach by comparing with the open-source and commercial fuzzers. Furthermore, in a real case, we experimented with the DLMS/COSEM for a smart meter and found that the test data can cause a unusual response. In summary, ICPFuzzer is a black-box fuzzing system that can automatically execute the testing process and reveal vulnerabilities that interrupt and crash industrial control communication. Not only improves the quality of ICS but also improves safety.
Published: 2021

3. Baicalin Rescues Cognitive Dysfunction, Mitigates Neurodegeneration, and Exerts Anti-Epileptic Effects Through Activating TLR4/MYD88/Caspase-3 Pathway in Rats

Author: Li Chu, Ye Lu, Lin Pei, Zhigang Xiao, Shaodan Zhang, Yuan Chen, Zhixia Jia, Jing Zhao, Jiali Yang, and Hui Shao
Subjects: Male, Spatial Learning, Pharmaceutical Science, Hippocampus, Caspase 3, Pharmacology, Neuroprotection, Rats, Sprague-Dawley, Epilepsy, TLR4/MYD88/Caspase-3, Memory, cognitive dysfunction, Drug Discovery, medicine, Animals, network pharmacology, Pentylenetetrazol, baicalin, Original Research, Flavonoids, Drug Design, Development and Therapy, biology, business.industry, Neurodegeneration, Neurodegenerative Diseases, pentylenetetrazol, medicine.disease, Rats, Toll-Like Receptor 4, Neuroprotective Agents, Myeloid Differentiation Factor 88, biology.protein, TLR4, epilepsy, Anticonvulsants, NeuN, business, Signal Transduction, medicine.drug
Abstract: Jiali Yang,1,&ast; Zhixia Jia,1,&ast; Zhigang Xiao,1 Jing Zhao,2 Ye Lu,2 Li Chu,3 Hui Shao,1,2 Lin Pei,1,2 Shaodan Zhang,4 Yuan Chen4 1School of Integrated Traditional Chinese and Western Medicine, Hebei University of Chinese Medicine, Shijiazhuang, Hebei, 050200, Peopleâs Republic of China; 2Hebei Key Laboratory of Turbidity, Hebei Academy of Chinese Medicine Sciences, Shijiazhuang, Hebei, 050011, Peopleâs Republic of China; 3School of Pharmacy, Hebei University of Chinese Medicine, Shijiazhuang, Hebei, 050200, Peopleâs Republic of China; 4Pediatrics, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, 050051, Peopleâs Republic of China&ast;These authors contributed equally to this workCorrespondence: Shaodan Zhang; Lin PeiPaediatrics, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, 050051, Peopleâs Republic of ChinaTel/Fax +86 13653115066; +86 13831190309Email 13653115066@163.com; peilin13831190309@126.comPurpose: This study aims to evaluate the beneficial effects of anti-epileptic mechanisms of baicalin (BA) on cognitive dysfunction and neurodegeneration in pentylenetetrazol (PTZ)-induced epileptic rats.Methods: First, PTZ-induced epileptic rats were administered intraperitoneally a sub-convulsive dose of PTZ (40âmg/kg) daily, and the seizure susceptibility (the degree of seizures and latency) was evaluated using Racineâs criterion. Then, classical behavioral experiments were performed to test whether BA ameliorated cognitive dysfunction. Neurodegeneration was assessed using Fluoro Jade-B (FJB), and NeuN staining was used to determine whether BA offered a neuroprotective role. After BA had been proven to possess anti-epileptic effects, its possible mechanisms were analyzed through network pharmacology. Finally, the key targets for predictive mechanisms were experimentally verified.Results: The epileptic model was successfully established, and BA had anti-epileptic effects. Epileptic rats displayed significant cognitive dysfunction, and BA markedly ameliorated cognitive dysfunction. Further, we also discovered that BA treatment mitigated neurodegeneration of the hippocampus CA3 regions, thereby ameliorated cognitive dysfunction of epileptic rats. Subsequent network pharmacology analysis was implemented to reveal a possible mechanism of BA in the anti-epileptic process and the TLR4/MYD88/Caspase-3 pathway was predicted. Finally, experimental studies showed that BA exerted an anti-epileptic effect by activating the TLR4/MYD88/Caspase-3 pathway in PTZ-induced epileptic rats.Conclusion: In conclusion, BA had a protective effect against PTZ-induced seizures. BA improved cognitive dysfunction and exerted a neuroprotective action. The anti-epileptic effects of BA may be potentially through activation of the TLR4/MYD88/Caspase-3 pathway.Keywords: baicalin, pentylenetetrazol, epilepsy, cognitive dysfunction, network pharmacology, TLR4/MYD88/Caspase-3
Published: 2021

4. Contamination, Distribution and Health Risk Assessment of Risk Elements in Topsoil for Amusement Parks in Xi’an, China

Author: Bin Guo, Dingming Zhang, Xiaofeng Wang, Xiaoxia Wang, Lin Pei, Yi Su, Xindong Wei, and Bo Zhang
Subjects: Hydrology, Topsoil, business.industry, Environmental Chemistry, Environmental science, Distribution (economics), Contamination, Spatial distribution, China, business, General Environmental Science
Published: 2020

5. A Land Use Regression Application into Simulating Spatial Distribution Characteristics of Particulate Matter (PM2.5) Concentration in City of Xi’an, China

Author: Bin Guo, Dingming Zhang, Donghai Zhang, Lin Pei, Xiaofeng Wang, and Xiaoxia Wang
Subjects: Ambient air pollution, business.industry, Environmental Chemistry, Environmental science, Distribution (economics), China, Land use regression, Atmospheric sciences, business, General Environmental Science
Published: 2020

6. Advances in Urban Meteorological Research in China

Author: Ning Zhang, Jianguo Tan, Weimei Jiang, Lin Pei, Ping Liang, Ju Li, Xuemei Wang, Shiguang Miao, Hongnian Liu, and Wupeng Du
Subjects: 010504 meteorology & atmospheric sciences, business.industry, Environmental resource management, Weather and climate, 010502 geochemistry & geophysics, 01 natural sciences, Ecosystem services, Data assimilation, Beijing, Urban planning, Urbanization, Environmental science, Urban heat island, business, Air quality index, 0105 earth and related environmental sciences
Abstract: Over the past decades, a large number of studies have been carried out in the field of urban meteorology in China. This paper summarizes the main progress in urban meteorology research from four aspects: urban meteorological observation network and field campaign, multi-scale model of urban meteorology, interaction between urban meteorology and atmospheric environment, and the impacts of urbanization on weather and climate. Major advances are as follows. China’s major cities have established or are improving comprehensive urban meteorological observation networks characterized by multi-platform, multi-variable, multi-scale, multi-link, and multi-function. Beijing, Nanjing, Shanghai, and other cities carried out urban meteorological field campaigns, which were included in the WMO research demonstration project. Wind tunnel experiments and scale-model outdoor experiments were successfully conducted. Multi-scale urban meteorological and air quality prediction numerical model systems have been developed and put into operational use. The urban heat island effect; urban impacts on precipitation, regional climate, and air quality; urban planning; and interaction between urban meteorology and atmospheric environment are extensively investigated. Finally, efforts to improve observational technology, data assimilation, and urban system modeling, to explore the impacts of urbanization on environment and human health, and to provide integrated urban hydro-meteorological climate and environmental services are planned ahead.
Published: 2020

7. The Potential of Serum Exosomal hsa_circ_0028861 as the Novel Diagnostic Biomarker of HBV-Derived Hepatocellular Cancer

Author: Hui Wang, Lin-Lin Cao, Yuanxiao Wang, Lin Pei, Mei Jia, and Zhihong Yue
Subjects: 0301 basic medicine, Cirrhosis, QH426-470, hsa_circ_0028861, medicine.disease_cause, Exosome, 03 medical and health sciences, 0302 clinical medicine, microRNA, Genetics, exosome, Medicine, Stage (cooking), neoplasms, Genetics (clinical), Original Research, Hepatitis B virus, business.industry, Microarray analysis techniques, circular RNA, medicine.disease, digestive system diseases, Microvesicles, hepatocellular cancer, 030104 developmental biology, 030220 oncology & carcinogenesis, Cancer research, Molecular Medicine, Biomarker (medicine), business, hepatitis B virus
Abstract: Hepatitis B virus (HBV)-derived hepatocellular cancer (HCC) is a serious threat to human health, especially in China. There is no highly sensitive and specific HCC biomarker at present, which makes it difficult to detect HCC at the early stage. Serum exosomal circular RNAs (circRNAs) have been reported as novel diagnostic and prognostic biomarkers of cancers. In the present study, we aimed to explore the diagnostic performance of serum exosomal circRNAs for HBV-derived HCC screening. At first, many circRNAs were found to be differentially expressed in the serum exosomes of HCC individuals by microarray analysis. The validation of dysregulated circRNAs by qRT-PCR revealed that serum exosomal hsa_circ_0028861 was decreased in HCC compared to chronic HBV and cirrhosis. Then, hsa_circ_0028861 was identified as a novel biomarker for HCC diagnosis with an area under the ROC curve (AUC) of 0.79 for discriminating HCC from chronic HBV and cirrhosis individuals. Hsa_circ_0028861 was capable of detecting small (AUC = 0.81), early-stage (AUC = 0.82) and AFP-negative [AFP (−)] (AUC = 0.78) tumors as well. The combination of hsa_circ_0028861 and AFP exhibited better diagnostic ability (AUC = 0.86 for discriminating HCC from chronic HBV and cirrhosis). Moreover, bioinformatics prediction suggested that hsa_circ_0028861 might influence HCC progression by regulating its targeted microRNAs (miRNAs) and downstream tumor-related signaling pathways. Collectively, our study reveals a novel diagnostic tool for HBV-derived HCC.
Published: 2021

8. The clinical values of dysregulated DNA methylation and demethylation intermediates in acute lymphoblastic leukemia

Author: Mei Jia, Zhihong Yue, Lin Pei, Hui Wang, Lin-Lin Cao, and Hangqi Liu
Subjects: Adult, Male, Adolescent, Lymphoblastic Leukemia, Inflammation, Disease, Cytosine, Young Adult, 03 medical and health sciences, 0302 clinical medicine, Biomarkers, Tumor, Humans, Medicine, Cell Lineage, Epigenetics, Child, Aged, Demethylation, biology, business.industry, Remission Induction, DNA, Neoplasm, Hematology, Methylation, DNA Methylation, Middle Aged, Precursor Cell Lymphoblastic Leukemia-Lymphoma, Ferritin, ROC Curve, Area Under Curve, 030220 oncology & carcinogenesis, DNA methylation, 5-Methylcytosine, Cancer research, biology.protein, Female, medicine.symptom, business, Oxidation-Reduction, 030215 immunology
Abstract: Objectives: DNA methylation is a well-known epigenetic modification, and it can be iteratively oxidized to 5-hydroxymethylcytosine (5-hmC), 5-formylcytosine (5-fC) and 5-carboxylcytosine (5-caC). Acute lymphoblastic leukemia (ALL) is a severe hematological disease, and it is essential to find out new biomarkers to better diagnose and cure ALL due to the development of chemo-resistance and low cure rate in adult ALL. This study aims to describe the role of global methylation and demethylation intermediates in ALL. Methods: The levels of global methylation and its oxidation products in the peripheral blood (PB) of ALL patients and healthy controls were determined by Enzyme-Linked Immunosorbent Assay (ELISA). Results: In this study, we described that global 5-mC, 5-hmC and 5-fC levels were dysregulated in ALL, and they were associated with clinical characteristics and genetic abnormalities of ALL patients. Interestingly, 5-mC and 5-hmC were closely related to inflammation, and the levels of 5-hmC were inversely correlated with C-Reactive protein (CRP) and ferritin. Finally, 5-mC and 5-hmC were associated with complete remission (CR), and 5-hmC was revealed as an independent prognostic indicator for ALL. Conclusion: This study described a novel role for global methylation and demethylation intermediates in ALL detection and prognosis, and provided new clue to distinguish high-risk patients and improve the curative effect on ALL patients.
Published: 2019

9. Dietary Structure and Nutritional Status of Chinese Beekeepers: Demographic Health Survey

Author: Lin Su, Qian Xu, Mingshan Xue, Zhangkai Jason Cheng, Lin Pei, Tiangang Zhu, Peng Liu, Boshi Wang, and Li Zhu
Subjects: Vitamin, Beekeeping, China, Population, Nutritional Status, Health Informatics, Composition of the human body, 030204 cardiovascular system & hematology, Overweight, MMSE, Toxicology, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Nutrient, Medicine, Humans, education, 030304 developmental biology, 0303 health sciences, education.field_of_study, Original Paper, body composition, business.industry, Public Health, Environmental and Occupational Health, beekeeper, Health Surveys, Diet, nutrition survey, chemistry, Agriculture, Quality of Life, Health education, Public aspects of medicine, RA1-1270, medicine.symptom, business
Abstract: Background Beekeeping and honey gathering are traditional forms of agricultural farming in China. However, only few studies have focused on the nutritional status and health level of this special occupational group. Objective By comparing the health status of apiculturists (beekeepers) and vegetable farmers in plain areas of Hubei Province, and analyzing the influence of dietary structure and intake on their nutritional level, this paper provides a scientific theoretical basis for the further development of health education and disease prevention for beekeepers. Methods From February to April 2016, 191/236 beekeepers (80.9% of the total beekeepers) with large-scale breeding (300-500 colonies) and 182 vegetable farmers in the same area were sampled by the cluster sampling method. Their nutrient composition was analyzed using a human body composition analyzer, dietary structure information was collected using the dietary frequency query method, and cognitive function was investigated. In addition, blood samples of both groups were collected. Results A total of 362 valid questionnaires (beekeepers/vegetable farmers: 185/177) were collected, with an effective response rate of 97.1% (362/373). Both beekeepers and vegetable farmers were overweight, and the beekeepers’ grip strength was much stronger than that of the vegetable farmers’ regardless of gender. The dietary structure of beekeepers is very unique: 29.7% (55/185) of beekeepers indicated consuming royal jelly regularly for more than 10 years. Their main foods are grain, cereals, and fresh vegetables; 68.1% (126/185) of the beekeepers never drank milk and other dairy products, and their overall nutrient intake is unbalanced. The average intake of cellulose in this group was also significantly higher than that in the epidemiological survey in the same sex and age group. The intake of vitamin A and selenium in the beekeepers group was significantly higher than that in the vegetable-farmers group (all P Conclusions The beekeepers in this area have their special dietary structure, body nutrient level, and disease characteristics. The cognitive level of the beekeepers who regularly consume royal jelly is significantly higher than that of their peers. The chronic diseases of this special occupational group are closely related to their lifestyle and nutritional status, so more attention and in-depth studies are needed to improve the quality of life of this population.
Published: 2021

10. Activation of TREK-1 Potassium Channel Improved Cognitive Deficits in Alzheimer's Disease Model Mice by Modulation of Glutamate Metabolic Pathway

Author: Xin Zeng, Li Lu, Bin Meng, Fang Li, Shu ning Zhou, Rui Yang, Wei lin Pei, and Xue Xi Wang
Subjects: TREK-1 potassium channel, endocrine system, Metabolic pathway, Modulation, business.industry, Glutamate receptor, Medicine, Cognition, Disease, business, human activities, Neuroscience
Abstract: Alzheimerʼs disease (AD) is a progressive neurodegenerative disease characterized by cognitive dysfunction. Glutamate (Glu) metabolism pathway mediated neurotoxicity is one of main factors causing memory impairment in AD. TWIK-related potassium channel-1 (TREK-1) exerts protective effect in brain ischemia, but the role of it in AD is unknown. In this study, the SAMP8 mice were used as an AD model, the age-matched SAMR1 mice as a control, we investigated the change trend of TREK-1 channel as well as AD related molecules in brains of SAMP8 mice and showed the expression levels of TREK-1 compensatory arose before 3 months of age, then began to decline. Meanwhile the levels of Tau and Glu increased with age while Ach level decreased over age. Next, using α-Linolenic acid (ALA) as an activator of TREK-1 channel, we showed that activation of TREK-1 channel improved the learning and memory deficits of SAMP8 mice aged in 6 months. Furthermore, we explored the possible mechanisms and found that the levels of molecules were closely related to the glutamate metabolism pathway. After the activation of TREK-1 channel, the damaged neurons and astrocyte were rescued, the levels of Glu and NMDAR were down-regulated, while the level of GLT-1 was up-regulated. These findings suggested that TREK-1 played the crucial role in the pathological progression of AD and activation of TREK-1 channel improved the cognitive deficits in SAMP8 mice which is mediated by Glu metabolism pathway. The TREK-1 potassium channel may be expected to be a new potential therapeutic target for AD.
Published: 2021

11. Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition) 1

Author: Klionsky, Daniel, Abdel-Aziz, Amal Kamal, Abdelfatah, Sara, Abdellatif, Mahmoud, Abdoli, Asghar, Abel, Steffen, Abeliovich, Hagai, Abildgaard, Marie, Abudu, Yakubu Princely, Acevedo-Arozena, Abraham, Adamopoulos, Iannis, Adeli, Khosrow, Adolph, Timon, Adornetto, Annagrazia, Aflaki, Elma, Agam, Galila, Agarwal, Anupam, Aggarwal, Bharat, Agnello, Maria, Agostinis, Patrizia, Agrewala, Javed, Agrotis, Alexander, Aguilar, Patricia, Ahmad, S Tariq, Ahmed, Zubair, Ahumada-Castro, Ulises, Aits, Sonja, Aizawa, Shu, Akkoc, Yunus, Akoumianaki, Tonia, Akpinar, Hafize Aysin, Al-Abd, Ahmed, Al-Akra, Lina, Al-Gharaibeh, Abeer, Alaoui-Jamali, Moulay, Alberti, Simon, Alcocer-Gómez, Elísabet, Alessandri, Cristiano, Ali, Muhammad, Alim Al-Bari, M Abdul, Aliwaini, Saeb, Alizadeh, Javad, Almacellas, Eugènia, Almasan, Alexandru, Alonso, Alicia, Alonso, Guillermo, Altan-Bonnet, Nihal, Altieri, Dario, Álvarez, Élida, Alves, Sara, Alves Da Costa, Cristine, Alzaharna, Mazen, Amadio, Marialaura, Amantini, Consuelo, Amaral, Cristina, Ambrosio, Susanna, Amer, Amal, Ammanathan, Veena, An, Zhenyi, Andersen, Stig, Andrabi, Shaida, Andrade-Silva, Magaiver, Andres, Allen, Angelini, Sabrina, Ann, David, Anozie, Uche, Ansari, Mohammad, Antas, Pedro, Antebi, Adam, Antón, Zuriñe, Anwar, Tahira, Apetoh, Lionel, Apostolova, Nadezda, Araki, Toshiyuki, Araki, Yasuhiro, Arasaki, Kohei, Araújo, Wagner, Araya, Jun, Arden, Catherine, Arévalo, Maria-Angeles, Arguelles, Sandro, Arias, Esperanza, Arikkath, Jyothi, Arimoto, Hirokazu, Ariosa, Aileen, Armstrong-James, Darius, Arnauné-Pelloquin, Laetitia, Aroca, Angeles, Arroyo, Daniela, Arsov, Ivica, Artero, Rubén, Asaro, Dalia Maria Lucia, Aschner, Michael, Ashrafizadeh, Milad, Ashur-Fabian, Osnat, Atanasov, Atanas, Au, Alicia, Auberger, Patrick, Auner, Holger, Aurelian, Laure, Autelli, Riccardo, Avagliano, Laura, Ávalos, Yenniffer, Aveic, Sanja, Aveleira, Célia Alexandra, Avin-Wittenberg, Tamar, Aydin, Yucel, Ayton, Scott, Ayyadevara, Srinivas, Azzopardi, Maria, Baba, Misuzu, Backer, Jonathan, Backues, Steven, Bae, Dong-Hun, Bae, Ok-Nam, Bae, Soo Han, Baehrecke, Eric, Baek, Ahruem, Baek, Seung-Hoon, Baek, Sung Hee, Bagetta, Giacinto, Bagniewska-Zadworna, Agnieszka, Bai, Hua, Bai, Jie, Bai, Xiyuan, Bai, Yidong, Bairagi, Nandadulal, Baksi, Shounak, Balbi, Teresa, Baldari, Cosima, Balduini, Walter, Ballabio, Andrea, Ballester, Maria, Balazadeh, Salma, Balzan, Rena, Bandopadhyay, Rina, Banerjee, Sreeparna, Banerjee, Sulagna, Bánréti, Ágnes, Bao, Yan, Baptista, Mauricio, Baracca, Alessandra, Barbati, Cristiana, Bargiela, Ariadna, Barilà, Daniela, Barlow, Peter, Barmada, Sami, Barreiro, Esther, Barreto, George, Bartek, Jiri, Bartel, Bonnie, Bartolome, Alberto, Barve, Gaurav, Basagoudanavar, Suresh, Bassham, Diane, Bast, Robert, Basu, Alakananda, Batoko, Henri, Batten, Isabella, Baulieu, Etienne, Baumgarner, Bradley, Bayry, Jagadeesh, Beale, Rupert, Beau, Isabelle, Beaumatin, Florian, Bechara, Luiz, Beck, George, Beers, Michael, Begun, Jakob, Behrends, Christian, Behrens, Georg, Bei, Roberto, Bejarano, Eloy, Bel, Shai, Behl, Christian, Belaid, Amine, Belgareh-Touzé, Naïma, Bellarosa, Cristina, Belleudi, Francesca, Belló Pérez, Melissa, Bello-Morales, Raquel, Beltran, Jackeline Soares de Oliveira, Beltran, Sebastián, Benbrook, Doris Mangiaracina, Bendorius, Mykolas, Benitez, Bruno, Benito-Cuesta, Irene, Bensalem, Julien, Berchtold, Martin, Berezowska, Sabina, Bergamaschi, Daniele, Bergami, Matteo, Bergmann, Andreas, Berliocchi, Laura, Berlioz-Torrent, Clarisse, Bernard, Amélie, Berthoux, Lionel, Besirli, Cagri, Besteiro, Sebastien, Betin, Virginie, Beyaert, Rudi, Bezbradica, Jelena, Bhaskar, Kiran, Bhatia-Kissova, Ingrid, Bhattacharya, Resham, Bhattacharya, Sujoy, Bhattacharyya, Shalmoli, Bhuiyan, Md Shenuarin, Bhutia, Sujit Kumar, Bi, Lanrong, Bi, Xiaolin, Biden, Trevor, Bijian, Krikor, Billes, Viktor, Binart, Nadine, Bincoletto, Claudia, Birgisdottir, Asa, Bjorkoy, Geir, Blanco, Gonzalo, Blas-Garcia, Ana, Blasiak, Janusz, Blomgran, Robert, Blomgren, Klas, Blum, Janice, Boada-Romero, Emilio, Boban, Mirta, Boesze-Battaglia, Kathleen, Boeuf, Philippe, Boland, Barry, Bomont, Pascale, Bonaldo, Paolo, Bonam, Srinivasa Reddy, Bonfili, Laura, Bonifacino, Juan, Boone, Brian, Bootman, Martin, Bordi, Matteo, Borner, Christoph, Bornhauser, Beat, Borthakur, Gautam, Bosch, Jürgen, Bose, Santanu, botana, luis, Botas, Juan, Boulanger, Chantal, Boulton, Michael, Bourdenx, Mathieu, Bourgeois, Benjamin, Bourke, Nollaig, Bousquet, Guilhem, Boya, Patricia, Bozhkov, Peter, Bozi, Luiz, Bozkurt, Tolga, Brackney, Doug, Brandts, Christian, Braun, Ralf, Braus, Gerhard, Bravo-Sagua, Roberto, Bravo-San Pedro, José, Brest, Patrick, Bringer, Marie-Agnès, Briones-Herrera, Alfredo, Broaddus, V Courtney, Brodersen, Peter, Brodsky, Jeffrey, Brody, Steven, Bronson, Paola, Bronstein, Jeff, Brown, Carolyn, Brown, Rhoderick, Brum, Patricia, Brumell, John, Brunetti-Pierri, Nicola, Bruno, Daniele, Bryson-Richardson, Robert, Bucci, Cecilia, Buchrieser, Carmen, Bueno, Marta, Buitrago-Molina, Laura Elisa, Buraschi, Simone, Buch, Shilpa, Buchan, J Ross, Buckingham, Erin, Budak, Hikmet, Budini, Mauricio, Bultynck, Geert, Burada, Florin, Burgoyne, Joseph, Burón, M Isabel, Bustos, Victor, Büttner, Sabrina, Butturini, Elena, Byrd, Aaron, Cabas, Isabel, Cabrera-Benitez, Sandra, Cadwell, Ken, Cai, Jingjing, Cai, Lu, Cai, Qian, Cairó, Montserrat, Calbet, Jose, Caldwell, Guy, Caldwell, Kim, Call, Jarrod, Calvani, Riccardo, Calvo, Ana, Calvo-Rubio Barrera, Miguel, Camara, Niels OS, Camonis, Jacques, Camougrand, Nadine, Campanella, Michelangelo, Campbell, Edward, Campbell-Valois, François-Xavier, Campello, Silvia, Campesi, Ilaria, Campos, Juliane, Camuzard, Olivier, Cancino, Jorge, Candido de Almeida, Danilo, Canesi, Laura, Caniggia, Isabella, Canonico, Barbara, Cantí, Carles, Cao, Bin, Caraglia, Michele, Caramés, Beatriz, Carchman, Evie, Cardenal-Muñoz, Elena, Cardenas, Cesar, Cardenas, Luis, Cardoso, Sandra, Carew, Jennifer, Carle, Georges, Carleton, Gillian, Carloni, Silvia, Carmona-Gutierrez, Didac, Carneiro, Leticia, Carnevali, Oliana, Carosi, Julian, Carra, Serena, Carrier, Alice, Carrier, Lucie, Carroll, Bernadette, Carter, A Brent, Carvalho, Andreia Neves, Casanova, Magali, Casas, Caty, Casas, Josefina, Cassioli, Chiara, Castillo, Eliseo, Castillo, Karen, Castillo-Lluva, Sonia, Castoldi, Francesca, Castori, Marco, Castro, Ariel, Castro-Caldas, Margarida, Castro-Hernandez, Javier, Castro-Obregon, Susana, Catz, Sergio, Cavadas, Claudia, Cavaliere, Federica, Cavallini, Gabriella, Cavinato, Maria, Cayuela, Maria, Cebollada Rica, Paula, Cecarini, Valentina, Cecconi, Francesco, Cechowska-Pasko, Marzanna, Cenci, Simone, Ceperuelo-Mallafré, Victòria, Cerqueira, João, Cerutti, Janete, Cervia, Davide, Cetintas, Vildan Bozok, Cetrullo, Silvia, Chae, Han-Jung, Chagin, Andrei, Chai, Chee-Yin, Chakrabarti, Gopal, Chakrabarti, Oishee, Chakraborty, Tapas, Chakraborty, Trinad, Chami, mounia, Chamilos, Georgios, Chan, David, Chan, Edmond, Chan, Edward, Chan, H.Y. Edwin, Chan, Helen, Chan, Hung, Chan, Matthew, Chan, Yau Sang, Chandra, Partha, Chang, Chih-Peng, Chang, Chunmei, Chang, Hao-Chun, Chang, Kai, Chao, Jie, Chapman, Tracey, Charlet-Berguerand, Nicolas, Chatterjee, Samrat, Chaube, Shail, Chaudhary, Anu, Chauhan, Santosh, Chaum, Edward, Checler, Frédéric, Cheetham, Michael, Chen, Chang-Shi, Chen, Guang-Chao, Chen, Jian-Fu, Chen, Liam, Chen, Leilei, Chen, Lin, Chen, Mingliang, Chen, Mu-Kuan, Chen, Ning, Chen, Quan, Chen, Ruey-Hwa, Chen, Shi, Chen, Wei, Chen, Weiqiang, Chen, Xin-Ming, Chen, Xiong-Wen, Chen, Xu, Chen, Yan, Chen, Ye-Guang, Chen, Yingyu, Chen, Yongqiang, Chen, Yu-Jen, Chen, Yue-Qin, Chen, Zhefan Stephen, Chen, Zhi, Chen, Zhi-Hua, Chen, Zhijian, Chen, Zhixiang, Cheng, Hanhua, Cheng, Jun, Cheng, Shi-Yuan, Cheng, Wei, Cheng, Xiaodong, Cheng, Xiu-Tang, Cheng, Yiyun, Cheng, Zhiyong, Chen, Zhong, Cheong, Heesun, Cheong, Jit Kong, Chernyak, Boris, Cherry, Sara, Cheung, Chi Fai Randy, Cheung, Chun Hei Antonio, Cheung, King-Ho, Chevet, Eric, Chi, Richard, Chiang, Alan Kwok Shing, Chiaradonna, Ferdinando, Chiarelli, Roberto, Chiariello, Mario, Chica, Nathalia, Chiocca, Susanna, Chiong, Mario, Chiou, Shih-Hwa, Chiramel, Abhilash, Chiurchiù, Valerio, Cho, Dong-Hyung, Choe, Seong-Kyu, Choi, Augustine, Choi, Mary, Choudhury, Kamalika Roy, Chow, Norman, Chu, Charleen, Chua, Jason, Chua, John Jia En, Chung, Hyewon, Chung, Kin Pan, Chung, Seockhoon, Chung, So-Hyang, Chung, Yuen-Li, Cianfanelli, Valentina, Ciechomska, Iwona, Cifuentes, Mariana, Cinque, Laura, Cirak, Sebahattin, Cirone, Mara, Clague, Michael, Clarke, Robert, Clementi, Emilio, Coccia, Eliana, Codogno, Patrice, Cohen, Ehud, Cohen, Mickael, Colasanti, Tania, Colasuonno, Fiorella, Colbert, Robert, Colell, Anna, Čolić, Miodrag, Coll, Nuria, Collins, Mark, Colombo, María, Colón-Ramos, Daniel, Combaret, Lydie, Comincini, Sergio, Cominetti, Márcia, Consiglio, Antonella, Conte, Andrea, Conti, Fabrizio, Contu, Viorica Raluca, Cookson, Mark, Coombs, Kevin, Coppens, Isabelle, Corasaniti, Maria Tiziana, Corkery, Dale, Cordes, Nils, Cortese, Katia, Costa, Maria do Carmo, Costantino, Sarah, Costelli, Paola, Coto-Montes, Ana, Crack, Peter, Crespo, Jose, Criollo, Alfredo, Crippa, Valeria, Cristofani, Riccardo, Csizmadia, Tamas, Cuadrado, Antonio, Cui, Bing, Cui, Jun, Cui, Yixian, Cui, Yong, Culetto, Emmanuel, Cumino, Andrea, Cybulsky, Andrey, Czaja, Mark, Czuczwar, Stanislaw, D'Adamo, Stefania, D'Amelio, Marcello, D'Arcangelo, Daniela, D'Lugos, Andrew, D'Orazi, Gabriella, da Silva, James, Dafsari, Hormos Salimi, Dagda, Ruben, Dagdas, Yasin, Daglia, Maria, Dai, Xiaoxia, Dai, Yun, Dai, Yuyuan, Dal Col, Jessica, Dalhaimer, Paul, Dalla Valle, Luisa, Dallenga, Tobias, Dalmasso, Guillaume, Damme, Markus, Dando, Ilaria, Dantuma, Nico, Darling, April, Das, Hiranmoy, Dasarathy, Srinivasan, Dasari, Santosh, Dash, Srikanta, Daumke, Oliver, Dauphinee, Adrian, Davies, Jeffrey, Dávila, Valeria, Davis, Roger, Davis, Tanja, Dayalan Naidu, Sharadha, De Amicis, Francesca, De Bosscher, Karolien, De Felice, Francesca, De Franceschi, Lucia, De Leonibus, Chiara, de Mattos Barbosa, Mayara, De Meyer, Guido, De Milito, Angelo, De Nunzio, Cosimo, De Palma, Clara, De Santi, Mauro, De Virgilio, Claudio, De Zio, Daniela, Debnath, Jayanta, DeBosch, Brian, Decuypere, Jean-Paul, Deehan, Mark, Deflorian, Gianluca, DeGregori, James, Dehay, Benjamin, Del Rio, Gabriel, Delaney, Joe, Delbridge, Lea, Delorme-Axford, Elizabeth, Delpino, M Victoria, Demarchi, Francesca, Dembitz, Vilma, Demers, Nicholas, Deng, Hongbin, Deng, Zhiqiang, Dengjel, Joern, Dent, Paul, Denton, Donna, DePamphilis, Melvin, Der, Channing, Deretic, Vojo, Descoteaux, Albert, Devis, Laura, Devkota, Sushil, Devuyst, Olivier, Dewson, Grant, Dharmasivam, Mahendiran, Dhiman, Rohan, di Bernardo, Diego, Di Cristina, Manlio, Di Domenico, Fabio, Di Fazio, Pietro, Di Fonzo, Alessio, Di Guardo, Giovanni, Di Guglielmo, Gianni, Di Leo, Luca, Di Malta, Chiara, Di Nardo, Alessia, Di Rienzo, Martina, Di Sano, Federica, Diallinas, George, Diao, Jiajie, Diaz-Araya, Guillermo, Díaz-Laviada, Inés, Dickinson, Jared, Diederich, Marc, Dieudé, Mélanie, Dikic, Ivan, Ding, Shiping, Ding, Wen-Xing, Dini, Luciana, Dinić, Jelena, Dinic, Miroslav, Dinkova-Kostova, Albena, Dionne, Marc, Distler, Jörg, Diwan, Abhinav, Dixon, Ian, Djavaheri-Mergny, Mojgan, Dobrinski, Ina, Dobrovinskaya, Oxana, Dobrowolski, Radek, Dobson, Renwick, Đokić, Jelena, Dokmeci Emre, Serap, Donadelli, Massimo, Dong, Bo, Dong, Xiaonan, Dong, Zhiwu, Dorn Ii, Gerald, Dotsch, Volker, Dou, Huan, Dou, Juan, Dowaidar, Moataz, Dridi, Sami, Drucker, Liat, Du, Ailian, Du, Caigan, Du, Guangwei, Du, Hai-Ning, Du, Li-Lin, du Toit, André, Duan, Shao-Bin, Duan, Xiaoqiong, Duarte, Sónia, Dubrovska, Anna, Dunlop, Elaine, Dupont, Nicolas, Durán, Raúl, Dwarakanath, Bilikere, Dyshlovoy, Sergey, Ebrahimi-Fakhari, Darius, Eckhart, Leopold, Edelstein, Charles, Efferth, Thomas, Eftekharpour, Eftekhar, Eichinger, Ludwig, Eid, Nabil, Eisenberg, Tobias, Eissa, N Tony, Eissa, Sanaa, Ejarque, Miriam, El Andaloussi, Abdeljabar, El-Hage, Nazira, El-Naggar, Shahenda, Eleuteri, Anna Maria, El-Shafey, Eman, Elgendy, Mohamed, Eliopoulos, Aristides, Elizalde, María, Elks, Philip, Elsasser, Hans-Peter, Elsherbiny, Eslam, Emerling, Brooke, Emre, N., Eng, Christina, Engedal, Nikolai, Engelbrecht, Anna-Mart, Engelsen, Agnete, Enserink, Jorrit, Escalante, Ricardo, Esclatine, Audrey, Escobar-Henriques, Mafalda, Eskelinen, Eeva-Liisa, Espert, Lucile, Eusebio, Makandjou-Ola, Fabrias, Gemma, Fabrizi, Cinzia, Facchiano, Antonio, Facchiano, Francesco, Fadeel, Bengt, Fader, Claudio, Faesen, Alex, Fairlie, W Douglas, Falcó, Alberto, Falkenburger, Bjorn, Fan, Daping, Fan, Jie, Fan, Yanbo, Fang, Evandro, Fang, Yanshan, Fang, Yognqi, Fanto, Manolis, Farfel-Becker, Tamar, Faure, Mathias, Fazeli, Gholamreza, Fedele, Anthony, Feldman, Arthur, Feng, Du, Feng, Jiachun, Feng, Lifeng, Feng, Yibin, Feng, Yuchen, Feng, Wei, Fenz Araujo, Thais, Ferguson, Thomas, Fernández, Álvaro, Fernandez-Checa, Jose, Fernández-Veledo, Sonia, Fernie, Alisdair, Ferrante, Anthony, Ferraresi, Alessandra, Ferrari, Merari, Ferreira, Julio, Ferro-Novick, Susan, Figueras, Antonio, Filadi, Riccardo, Filigheddu, Nicoletta, Filippi-Chiela, Eduardo, Filomeni, Giuseppe, Fimia, Gian Maria, Fineschi, Vittorio, Finetti, Francesca, Finkbeiner, Steven, Fisher, Edward, Fisher, Paul, Flamigni, Flavio, Fliesler, Steven, Flo, Trude, Florance, Ida, Florey, Oliver, Florio, Tullio, Fodor, Erika, Follo, Carlo, Fon, Edward, Forlino, Antonella, Fornai, Francesco, Fortini, Paola, Fracassi, Anna, Fraldi, Alessandro, Franco, Brunella, Franco, Rodrigo, Franconi, Flavia, Frankel, Lisa, Friedman, Scott, Fröhlich, Leopold, Frühbeck, Gema, Fuentes, Jose, Fujiki, Yukio, Fujita, Naonobu, Fujiwara, Yuuki, Fukuda, Mitsunori, Fulda, Simone, Furic, Luc, Furuya, Norihiko, Fusco, Carmela, Gack, Michaela, Gaffke, Lidia, Galadari, Sehamuddin, Galasso, Alessia, Galindo, Maria, Gallolu Kankanamalage, Sachith, Galluzzi, Lorenzo, Galy, Vincent, Gammoh, Noor, Gan, Boyi, Ganley, Ian, Gao, Feng, Gao, Hui, Gao, Minghui, Gao, Ping, Gao, Shou-Jiang, Gao, Wentao, Gao, Xiaobo, Garcera, Ana, Garcia, Maria Noé, Garcia, Verónica, García-del Portillo, Francisco, Garcia-Escudero, Vega, Garcia-Garcia, Aracely, Garcia-Macia, Marina, García-Moreno, Diana, Garcia-Ruiz, Carmen, García-Sanz, Patricia, Garg, Abhishek, Gargini, Ricardo, Garofalo, Tina, Garry, Robert, Gassen, Nils, Gatica, Damian, Ge, Liang, Ge, Wanzhong, Geiss-Friedlander, Ruth, Gelfi, Cecilia, Genschik, Pascal, Gentle, Ian, Gerbino, Valeria, Gerhardt, Christoph, Germain, Kyla, Germain, Marc, Gewirtz, David, Ghasemipour Afshar, Elham, Ghavami, Saeid, Ghigo, Alessandra, Ghosh, Manosij, Giamas, Georgios, Giampietri, Claudia, Giatromanolaki, Alexandra, Gibson, Gary, Gibson, Spencer, Ginet, Vanessa, Giniger, Edward, Giorgi, Carlotta, Girao, Henrique, Girardin, Stephen, Giridharan, Mridhula, Giuliano, Sandy, Giulivi, Cecilia, Giuriato, Sylvie, Giustiniani, Julien, Gluschko, Alexander, Goder, Veit, Goginashvili, Alexander, Golab, Jakub, Goldstone, David, Golebiewska, Anna, Gomes, Luciana, Gomez, Rodrigo, Gómez-Sánchez, Rubén, Gomez-Puerto, Maria Catalina, Gomez-Sintes, Raquel, Gong, Qingqiu, Goni, Felix, González-Gallego, Javier, Gonzalez-Hernandez, Tomas, Gonzalez-Polo, Rosa, Gonzalez-Reyes, Jose, González-Rodríguez, Patricia, Goping, Ing Swie, Gorbatyuk, Marina, Gorbunov, Nikolai, Görgülü, Kıvanç, Gorojod, Roxana, Gorski, Sharon, Goruppi, Sandro, Gotor, Cecilia, Gottlieb, Roberta, Gozes, Illana, Gozuacik, Devrim, Graef, Martin, Gräler, Markus, Granatiero, Veronica, Grasso, Daniel, Gray, Joshua, Green, Douglas, Greenhough, Alexander, Gregory, Stephen, Griffin, Edward, Grinstaff, Mark, Gros, Frederic, Grose, Charles, Gross, Angelina, Gruber, Florian, Grumati, Paolo, Grune, Tilman, Gu, Xueyan, Guan, Jun-Lin, Guardia, Carlos, Guda, Kishore, Guerra, Flora, Guerri, Consuelo, Guha, Prasun, Guillén, Carlos, Gujar, Shashi, Gukovskaya, Anna, Gukovsky, Ilya, Gunst, Jan, Günther, Andreas, Guntur, Anyonya, Guo, Chuanyong, Guo, Chun, Guo, Hongqing, Guo, Lian-Wang, Guo, Ming, Gupta, Pawan, Gupta, Shashi Kumar, Gupta, Swapnil, Gupta, Veer Bala, Gupta, Vivek, Gustafsson, Asa, Gutterman, David, H B, Ranjitha, Haapasalo, Annakaisa, Haber, James, Hać, Aleksandra, Hadano, Shinji, Hafrén, Anders, Haidar, Mansour, Hall, Belinda, Halldén, Gunnel, Hamacher-Brady, Anne, Hamann, Andrea, Hamasaki, Maho, Han, Weidong, Hansen, Malene, Hanson, Phyllis, Hao, Zijian, Harada, Masaru, Harhaji-Trajkovic, Ljubica, Hariharan, Nirmala, Haroon, Nigil, Harris, James, Hasegawa, Takafumi, Hasima Nagoor, Noor, Haspel, Jeffrey, Haucke, Volker, Hawkins, Wayne, Hay, Bruce, Haynes, Cole, Hayrabedyan, Soren, Hays, Thomas, He, Congcong, He, Qin, He, Rong-Rong, He, You-Wen, He, Yu-Ying, Heakal, Yasser, Heberle, Alexander, Hejtmancik, J Fielding, Helgason, Gudmundur Vignir, Henkel, Vanessa, Herb, Marc, Hergovich, Alexander, Herman-Antosiewicz, Anna, Hernández, Agustín, Hernandez, Carlos, Hernandez-Diaz, Sergio, Hernandez-Gea, Virginia, Herpin, Amaury, Herreros, Judit, Hervás, Javier, Hesselson, Daniel, Hetz, Claudio, Heussler, Volker, Higuchi, Yujiro, Hilfiker, Sabine, Hill, Joseph, Hlavacek, William, Ho, Emmanuel, Ho, Idy, Ho, Philip Wing-Lok, Ho, Shu-Leong, Ho, Wan Yun, Hobbs, G Aaron, Hochstrasser, Mark, Hoet, Peter, Hofius, Daniel, Hofman, Paul, Höhn, Annika, Holmberg, Carina, Hombrebueno, Jose, Yi-Ren Hong, Chang-Won Hong, Hooper, Lora, Hoppe, Thorsten, Horos, Rastislav, Hoshida, Yujin, Hsin, I-Lun, Hsu, Hsin-Yun, Hu, Bing, Hu, Dong, Hu, Li-Fang, Hu, Ming Chang, Hu, Ronggui, Hu, Wei, Hu, Yu-Chen, Hu, Zhuo-Wei, Hua, Fang, Hua, Jinlian, Hua, Yingqi, Huan, Chongmin, Huang, Canhua, Huang, Chuanshu, Huang, Chuanxin, Huang, Chunling, Huang, Haishan, Huang, Kun, Huang, Michael, Huang, Rui, Huang, Shan, Huang, Tianzhi, Huang, Xing, Huang, Yuxiang Jack, Huber, Tobias, Hubert, Virginie, Hubner, Christian, Hughes, Stephanie, Hughes, William, Humbert, Magali, Hummer, Gerhard, Hurley, James, Hussain, Sabah, Hussain, Salik, Hussey, Patrick, Hutabarat, Martina, Hwang, Hui-Yun, Hwang, Seungmin, Ieni, Antonio, Ikeda, Fumiyo, Imagawa, Yusuke, Imai, Yuzuru, Imbriano, Carol, Imoto, Masaya, Inman, Denise, Inoki, Ken, Iovanna, Juan, Iozzo, Renato, Ippolito, Giuseppe, Irazoqui, Javier, Iribarren, Pablo, Ishaq, Mohd, ISHIKAWA, Makoto, Ishimwe, Nestor, Isidoro, Ciro, Ismail, Nahed, Issazadeh-Navikas, Shohreh, Itakura, Eisuke, Ito, Daisuke, Ivankovic, Davor, Ivanova, Saška, Iyer, Anand Krishnan V, Izquierdo, José, Izumi, Masanori, Jäättelä, Marja, Jabir, Majid Sakhi, Jackson, William, Jacobo-Herrera, Nadia, Jacomin, Anne-Claire, Jacquin, Elise, Jadiya, Pooja, Jaeschke, Hartmut, Jagannath, Chinnaswamy, Jakobi, Arjen, Jakobsson, Johan, Janji, Bassam, Jansen-Dürr, Pidder, Jansson, Patric, Jantsch, Jonathan, Januszewski, Sławomir, Jassey, Alagie, Jean, Steve, Jeltsch-David, Hélène, Jendelova, Pavla, Jenny, Andreas, Jensen, Thomas, Jessen, Niels, Jewell, Jenna, Ji, Jing, Jia, Lijun, Jia, Rui, Jiang, Liwen, Jiang, Qing, Jiang, Richeng, Jiang, Teng, Jiang, Xuejun, Jiang, Yu, Jimenez-Sanchez, Maria, Jin, Eun-Jung, Jin, Fengyan, Jin, Hongchuan, Jin, Li, Jin, Luqi, Jin, Meiyan, Jin, Si, Jo, Eun-Kyeong, Joffre, Carine, Johansen, Terje, Johnson, Gail, Johnston, Simon, Jokitalo, Eija, Jolly, Mohit Kumar, Joosten, Leo, Jordan, Joaquin, Joseph, Bertrand, Ju, Dianwen, Ju, Jeong-Sun, Ju, Jingfang, Juárez, Esmeralda, Judith, Delphine, Juhász, Gábor, Jun, Youngsoo, Jung, Chang Hwa, Jung, Sung-Chul, Jung, Yong Keun, Jungbluth, Heinz, Jungverdorben, Johannes, Just, Steffen, Kaarniranta, Kai, Kaasik, Allen, Kabuta, Tomohiro, Kaganovich, Daniel, Kahana, Alon, Kain, Renate, Kajimura, Shinjo, Kalamvoki, Maria, Kalia, Manjula, Kalinowski, Danuta, Kaludercic, Nina, Kalvari, Ioanna, Kaminska, Joanna, Kaminskyy, Vitaliy, Kanamori, Hiromitsu, Kanasaki, Keizo, Kang, Chanhee, Kang, Rui, Kang, Sang Sun, Kaniyappan, Senthilvelrajan, Kanki, Tomotake, Kanneganti, Thirumala-Devi, Kanthasamy, Anumantha, Kanthasamy, Arthi, Kantorow, Marc, Kapuy, Orsolya, Karamouzis, Michalis, Karim, Md Razaul, Karmakar, Parimal, Katare, Rajesh, Kato, Masaru, Kaufmann, Stefan, Kauppinen, Anu, Kaushal, Gur, Kaushik, Susmita, Kawasaki, Kiyoshi, Kazan, Kemal, Ke, Po-Yuan, Keating, Damien, Keber, Ursula, Kehrl, John, Keller, Kate, Keller, Christian, Kemper, Jongsook Kim, Kenific, Candia, Kepp, Oliver, Kermorgant, Stephanie, Kern, Andreas, Ketteler, Robin, Keulers, Tom, Khalfin, Boris, Khalil, Hany, Khambu, Bilon, Khan, Shahid, Khandelwal, Vinoth Kumar Megraj, Khandia, Rekha, Kho, Widuri, Khobrekar, Noopur, Khuansuwan, Sataree, Khundadze, Mukhran, Killackey, Samuel, Kim, Dasol, Kim, Deok Ryong, Kim, Do-Hyung, Kim, Dong-Eun, Kim, Eun Young, Kim, Eun-Kyoung, Kim, Hak-Rim, Kim, Hee-Sik, Kim, Hyung Ryong, Kim, Jeong Hun, Kim, Jin Kyung, Kim, Jin-Hoi, Kim, Joungmok, Kim, Ju Hwan, Kim, Keun Il, Kim, Peter, Kim, Seong-Jun, Kimball, Scot, Kimchi, 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Kazuyuki, Kuenen, Sabine, Kuerschner, Lars, Kukar, Thomas, Kumar, Ajay, Kumar, Ashok, Kumar, Deepak, Kumar, Dhiraj, Kumar, Sharad, Kume, Shinji, Kumsta, Caroline, Kundu, Chanakya, Kundu, Mondira, Kunnumakkara, Ajaikumar, Kurgan, Lukasz, Kutateladze, Tatiana, Kutlu, Ozlem, Kwak, SeongAe, Kwon, Ho Jeong, Kwon, Taeg Kyu, Kwon, Yong Tae, Kyrmizi, Irene, La Spada, Albert, Labonté, Patrick, Ladoire, Sylvain, Laface, Ilaria, Lafont, Frank, Lagace, Diane, Lahiri, Vikramjit, Lai, Zhibing, Laird, Angela, Lakkaraju, Aparna, Lamark, Trond, Lan, Sheng-Hui, Landajuela, Ane, Lane, Darius, Lane, Jon, Lang, Charles, Lange, Carsten, Langel, Ülo, Langer, Rupert, Lapaquette, Pierre, Laporte, Jocelyn, LaRusso, Nicholas, Lastres-Becker, Isabel, Lau, Wilson Chun Yu, Laurie, Gordon, Lavandero, Sergio, Law, Betty Yuen Kwan, Law, Helen Ka-wai, Layfield, Rob, Le, Weidong, Le Stunff, Herve, Leary, Alexandre, Lebrun, Jean-Jacques, Leck, Lionel, Leduc-Gaudet, Jean-Philippe, Lee, Changwook, Lee, Chung-Pei, Lee, 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Chengyu, Liang, Qiangrong, Liang, Weicheng, Liang, Yongheng, Liang, YongTian, Liao, Guanghong, Liao, Lujian, Liao, Mingzhi, Liao, Yung-Feng, Librizzi, Mariangela, Lie, Pearl, Lilly, Mary, Lim, Hyunjung, Lima, Thania, Limana, Federica, Lin, Chao, Lin, Chih-Wen, Lin, Dar-Shong, Lin, Fu-Cheng, Lin, Jiandie, Lin, Kurt, Lin, Kwang-Huei, Lin, Liang-Tzung, LIN, Pei-Hui, Lin, Qiong, Lin, Shaofeng, Lin, Su-Ju, Lin, Wenyu, Lin, Xueying, Lin, Yao-Xin, Lin, Yee-Shin, Linden, Rafael, Lindner, Paula, Ling, Shuo-Chien, Lingor, Paul, Linnemann, Amelia, Liou, Yih-Cherng, Lipinski, Marta, Lipovšek, Saška, Lira, Vitor, Lisiak, Natalia, Liton, Paloma, Liu, Chao, Liu, Ching-Hsuan, Liu, Chun-Feng, Liu, Cui Hua, Liu, Fang, Liu, Hao, Liu, Hsiao-Sheng, Liu, Hua-feng, Liu, Huifang, Liu, Jia, Liu, Jing, Liu, Julia, Liu, Leyuan, Liu, Longhua, Liu, Meilian, Liu, Qin, Liu, Wei, Liu, Wende, Liu, Xiao-Hong, Liu, Xiaodong, Liu, Xingguo, Liu, Xu, Liu, Xuedong, Liu, Yanfen, Liu, Yang, Liu, Yueyang, Liu, Yule, 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Elena, Uchiyama, Yasuo, Ugun-Klusek, Aslihan, Uhlig, Holm, Ułamek-Kozioł, Marzena, Ulasov, Ilya, Umekawa, Midori, Ungermann, Christian, Unno, Rei, Urbe, Sylvie, Uribe-Carretero, Elisabet, Üstün, Suayib, Uversky, Vladimir, Vaccari, Thomas, Vaccaro, Maria, Vahsen, Björn, Vakifahmetoglu-Norberg, Helin, Valdor, Rut, Valente, Maria, Valko, Ayelén, Vallee, Richard, Valverde, Angela, Van Den Berghe, Greet, van der Veen, Stijn, Van Kaer, Luc, van Loosdregt, Jorg, van Wijk, Sjoerd, Vandenberghe, Wim, Vanhorebeek, Ilse, Vannier-Santos, Marcos, Vannini, Nicola, Vanrell, M Cristina, Vantaggiato, Chiara, Varano, Gabriele, Varela-Nieto, Isabel, Varga, Máté, Vasconcelos, M Helena, Vats, Somya, Vavvas, Demetrios, Vega-Naredo, Ignacio, Vega-Rubin-de-Celis, Silvia, Velasco, Guillermo, Velázquez, Ariadna, Vellai, Tibor, Vellenga, Edo, Velotti, Francesca, Verdier, Mireille, Verginis, Panayotis, Vergne, Isabelle, Verkade, Paul, Verma, Manish, Verstreken, Patrik, Vervliet, Tim, Vervoorts, Jörg, Vessoni, Alexandre, Victor, Victor, Vidal, Michel, Vidoni, Chiara, Vieira, Otilia, Vierstra, Richard, Viganó, Sonia, Vihinen, Helena, Vijayan, Vinoy, Vila, Miquel, Vilar, Marçal, Villalba, José, Villalobo, Antonio, Villarejo-Zori, Beatriz, Villarroya, Francesc, Villarroya, Joan, Vincent, Olivier, Vindis, Cecile, Viret, Christophe, Viscomi, Maria Teresa, Visnjic, Dora, Vitale, Ilio, Vocadlo, David, Voitsekhovskaja, Olga, Volonté, Cinzia, Volta, Mattia, Vomero, Marta, Von Haefen, Clarissa, Vooijs, Marc, Voos, Wolfgang, Vucicevic, Ljubica, Wade-Martins, Richard, Waguri, Satoshi, Waite, Kenrick, Wakatsuki, Shuji, Walker, David, Walker, Mark, Walker, Simon, Walter, Jochen, Wandosell, Francisco, Wang, Bo, Wang, Chao-Yung, Wang, Chen, Wang, Chenran, Wang, Chenwei, Wang, Cun-Yu, Wang, Dong, Wang, Fangyang, Wang, Feng, Wang, Fengming, Wang, Guansong, Wang, Han, Wang, Hao, Wang, Hexiang, Wang, Hong-Gang, Wang, Jianrong, Wang, Jigang, Wang, Jiou, Wang, Jundong, Wang, Kui, Wang, Lianrong, Wang, Liming, Wang, Maggie Haitian, Wang, Meiqing, Wang, Nanbu, Wang, PengWei, Wang, PeiPei, Wang, Ping, Wang, Qing Jun, Wang, Qing, Wang, Qing Kenneth, Wang, Qiong, Wang, Wen-Tao, Wang, Wuyang, Wang, Xinnan, Wang, Xuejun, Wang, Yan, Wang, Yanchang, Wang, Yanzhuang, Wang, Yen-Yun, Wang, Yihua, Wang, Yipeng, Wang, Yu, wang, yuqi, Wang, Zhe, Wang, Zhenyu, Wang, Zhouguang, Warnes, Gary, Warnsmann, Verena, Watada, Hirotaka, Watanabe, Eizo, Watchon, Maxinne, Wawrzyńska, Anna, Weaver, Timothy, Wegrzyn, Grzegorz, Wehman, Ann, Wei, Huafeng, Wei, Lei, Wei, Taotao, Wei, Yongjie, Weiergräber, Oliver, Weihl, Conrad, Weindl, Günther, Weiskirchen, Ralf, Wells, Alan, Wen, Runxia, Wen, Xin, Werner, Antonia, Weykopf, Beatrice, Wheatley, Sally, Whitton, J Lindsay, Whitworth, Alexander, Wiktorska, Katarzyna, Wildenberg, Manon, Wileman, Tom, Wilkinson, Simon, Willbold, Dieter, Williams, Brett, Williams, Robin, Williams, Roger, Williamson, Peter, Wilson, Richard, Winner, Beate, Winsor, Nathaniel, Witkin, Steven, Wodrich, Harald, Woehlbier, Ute, Wollert, Thomas, Wong, Esther, Wong, Jack Ho, Wong, Richard, Wong, Vincent Kam Wai, Wong, W Wei-Lynn, Wu, An-Guo, Wu, Chengbiao, Wu, Jian, Wu, Junfang, Wu, Kenneth, Wu, Min, Wu, Shan-Ying, Wu, Shengzhou, Wu, Shu-Yan, Wu, Shufang, Wu, William, Wu, Xiaohong, Wu, Xiaoqing, Wu, Yao-Wen, Wu, Yihua, Xavier, Ramnik, Xia, Hongguang, Xia, Lixin, Xia, Zhengyuan, Xiang, Ge, Xiang, Jin, Xiang, Mingliang, Xiang, Wei, Xiao, Bin, Xiao, Guozhi, Xiao, Hengyi, Xiao, Hong-tao, Xiao, Jian, Xiao, Lan, Xiao, Shi, Xiao, Yin, Xie, Baoming, Xie, Chuan-Ming, Xie, Min, Xie, Yuxiang, Xie, Zhiping, Xie, Zhonglin, Xilouri, Maria, Xu, Congfeng, Xu, En, Xu, Haoxing, Xu, Jing, Xu, Jinrong, Xu, Liang, Xu, Wen Wen, Xu, Xiulong, Xue, Yu, Yakhine-Diop, Sokhna, Yamaguchi, Masamitsu, Yamaguchi, Osamu, Yamamoto, Ai, Yamashina, Shunhei, Yan, Shengmin, Yan, Shian-Jang, Yan, Zhen, Yanagi, Yasuo, Yang, Chuanbin, Yang, Dun-Sheng, Yang, Huan, Yang, Huang-Tian, Yang, Hui, Yang, Jin-Ming, Yang, Jing, Yang, Jingyu, Yang, Ling, Yang, Liu, Yang, Ming, Yang, Pei-Ming, Yang, Qian, Yang, Seungwon, Yang, Shu, Yang, Shun-Fa, Yang, Wannian, Yang, Wei Yuan, Yang, Xiaoyong, Yang, Xuesong, Yang, Yi, Yang, Ying, Yao, Honghong, Yao, Shenggen, Yao, Xiaoqiang, Yao, Yong-Gang, Yao, Yong-Ming, Yasui, Takahiro, Yazdankhah, Meysam, Yen, Paul, Yi, Cong, Yin, Xiao-Ming, Yin, Yanhai, Yin, Zhangyuan, Yin, Ziyi, Ying, Meidan, Ying, Zheng, Yip, Calvin, Yiu, Stephanie Pei Tung, Yoo, Young, Yoshida, Kiyotsugu, Yoshii, Saori, Yoshimori, Tamotsu, Yousefi, Bahman, Yu, Boxuan, Yu, Haiyang, Yu, Jun, Yu, Li, Yu, Ming-Lung, Yu, Seong-Woon, Yu, Victor, Yu, W Haung, Yu, Zhengping, Yu, Zhou, Yuan, Junying, Yuan, Ling-Qing, Yuan, Shilin, Yuan, Shyng-Shiou, Yuan, Yanggang, Yuan, Zengqiang, Yue, Jianbo, Yue, Zhenyu, Yun, Jeanho, Yung, Raymond, Zacks, David, Zaffagnini, Gabriele, Zambelli, Vanessa, Zanella, Isabella, Zang, Qun, Zanivan, Sara, Zappavigna, Silvia, Zaragoza, Pilar, Zarbalis, Konstantinos, Zarebkohan, Amir, Zarrouk, Amira, Zeitlin, Scott, Zeng, Jialiu, Zeng, Ju-deng, Žerovnik, Eva, Zhan, Lixuan, Zhang, Bin, Zhang, Donna, Zhang, Hanlin, Zhang, Hong, Zhang, Honghe, Zhang, Huafeng, Zhang, Huaye, Zhang, Hui, Zhang, Hui-Ling, Zhang, Jianbin, Zhang, Jianhua, Zhang, Jing-Pu, Zhang, Kalin, Zhang, Leshuai, Zhang, Lin, Zhang, Lisheng, Zhang, Lu, Zhang, Luoying, Zhang, Menghuan, Zhang, Peng, Zhang, Sheng, Zhang, Wei, Zhang, Xiangnan, Zhang, Xiao-Wei, Zhang, Xiaolei, Zhang, Xiaoyan, Zhang, Xin, Zhang, Xinxin, Zhang, Xu Dong, Zhang, Yang, Zhang, Yanjin, Zhang, Yi, Zhang, Ying-Dong, Zhang, Yingmei, Zhang, Yuan-Yuan, Zhang, Yuchen, Zhang, Zhe, Zhang, Zhengguang, Zhang, Zhibing, Zhang, Zhihai, Zhang, Zhiyong, Zhang, Zili, Zhao, Haobin, Zhao, Lei, Zhao, Shuang, Zhao, Tongbiao, Zhao, Xiao-Fan, Zhao, Ying, Zhao, Yongchao, Zhao, Yongliang, Zhao, Yuting, Zheng, Guoping, Zheng, Kai, Zheng, Ling, Zheng, Shizhong, Zheng, Xi-Long, Zheng, Yi, Zheng, Zu-Guo, Zhivotovsky, Boris, Zhong, Qing, Zhou, Ao, Zhou, Ben, Zhou, Cefan, ZHOU, Gang, Zhou, Hao, Zhou, Hong, Zhou, Hongbo, Zhou, Jie, Zhou, Jing, Zhou, Jiyong, Zhou, Kailiang, Zhou, Rongjia, Zhou, Xu-jie, Zhou, Yanshuang, Zhou, Yinghong, Zhou, Yubin, Zhou, Zheng-Yu, Zhou, Zhou, Zhu, Binglin, Zhu, Changlian, Zhu, Guo-Qing, Zhu, Haining, Zhu, Hongxin, Zhu, Hua, Zhu, Wei-Guo, Zhu, Yanping, Zhu, Yushan, Zhuang, Haixia, Zhuang, Xiaohong, Zientara-Rytter, Katarzyna, Zimmermann, Christine, Ziviani, Elena, Zoladek, Teresa, Zong, Wei-Xing, Zorov, Dmitry, Zorzano, Antonio, Zou, Weiping, Zou, Zhen, Zou, Zhengzhi, Zuryn, Steven, Zwerschke, Werner, Brand-Saberi, Beate, Dong, X Charlie, Kenchappa, Chandra Shekar, Li, Zuguo, Lin, Yong, Oshima, Shigeru, Rong, Yueguang, Sluimer, Judith, Stallings, Christina, Tong, Chun-Kit, Ahmad, S. Tariq, Alim Al-Bari, M. Abdul, Bechara, Luiz R.G., Behrens, Georg M.N., Bhuiyan, Md. Shenuarin, Broaddus, V. Courtney, Buchan, J. Ross, Burón, M. Isabel, Carter, A. Brent, Chan, Matthew T.V., Choi, Augustine M.K., D’Adamo, Stefania, D’Amelio, Marcello, D’Arcangelo, Daniela, D’Lugos, Andrew, D’Orazi, Gabriella, De Meyer, Guido R.Y., Delpino, M. Victoria, Distler, Jörg H.W., Dixon, Ian M.C., Dobson, Renwick C.J., 2nd Dorn, Gerald, Eissa, N. Tony, Engelsen, Agnete S.T., Fairlie, W. Douglas, Ferreira, Julio C.B., H.B., Ranjitha, Hanson, Phyllis I., Hejtmancik, J. Fielding, Ho, Idy H.T., Hobbs, G. Aaron, Hoet, Peter H.M., Huang, Michael L.H., Iyer, Anand Krishnan V., Johnson, Gail V.W., Joosten, Leo A.B., Karim, Md. Razaul, Kaufmann, Stefan H.E., Ko, Ben C.B., Leck, Lionel Y.W., Lima, Thania R.R., Livingston, J. Andrew, Martin, Alexandre P.J., Montes, L. Ruth, Murphy, J. Patrick, Ng, Charlene C.W., Nicolao, M. Celeste, O’Donovan, Tracey, O’Leary, Seónadh, O’Rourke, Eyleen, O’Sullivan, Mary, O’Sullivan, Timothy, Omary, M. Bishr, Pereira, Gustavo J.S., Ratnayaka, J. Arjuna, Riazuddin, S. Amer, Rouschop, Kasper M.A., Sanderson, J. Thomas, Scaglione, K. Matthew, Schapira, Anthony H.V., Scovassi, A. Ivana, St. Clair, Daret, Sunahara, Karen K.S., Symons, J. David, Triola, Gemma, van Wijk, Sjoerd J.L., Vanrell, M. Cristina, Vasconcelos, M. Helena, Whitton, J. Lindsay, Williams, Robin S.B., Wong, W. Wei-Lynn, Wu, William K.K., Yakhine-Diop, Sokhna M.S., Yu, W. Haung, Zhang, Kalin Y.B., Dong, X. Charlie, Ain Shams University [ASU], Johannes Gutenberg - Universität Mainz = Johannes Gutenberg University [JGU], Medical University Graz, Centre de Recherche des Cordeliers [CRC (UMR_S_1138 / U1138)], Institut Pasteur d'Iran, Leibniz Institute of Plant Biochemistry [IPB], The University of Texas M.D. Anderson Cancer Center [Houston], Institut de pharmacologie moléculaire et cellulaire [IPMC], Lipides - Nutrition - Cancer [Dijon - U1231] [LNC], Centre méditerranéen de médecine moléculaire [C3M], Institut de Biologie Valrose [IBV], Petites Molécules de neuroprotection, neurorégénération et remyélinisation, Signalisation Hormonale, Physiopathologie Endocrinienne et Métabolique, Institut Cochin [IC UM3 (UMR 8104 / U1016)], Institut NeuroMyoGène [INMG], Paris-Centre de Recherche Cardiovasculaire [PARCC (UMR_S 970/ U970)], Marqueurs cardiovasculaires en situation de stress [MASCOT (UMR_S_942 / U942)], Institut de Recherche sur le Cancer et le Vieillissement [IRCAN], Centre de Recherche en Cancérologie de Marseille [CRCM], Centre for Integrative Biology - CBI [Inserm U964 - CNRS UMR7104 - IGBMC], Oncogenesis, Stress, Signaling [OSS], Institut Necker Enfants-Malades [INEM - UM 111 (UMR 8253 / U1151)], Institut de Biologie Intégrative de la Cellule [I2BC], Microbes, Intestin, Inflammation et Susceptibilité de l'Hôte [M2iSH], Centre de Recherches en Cancérologie de Toulouse [CRCT], Physiopathologie et traitement des maladies du foie, Centre d’Infection et d’Immunité de Lille - INSERM U 1019 - UMR 9017 - UMR 8204 [CIIL], Institut de Génétique et de Biologie Moléculaire et Cellulaire [IGBMC], Laboratoire Bio-PeroxIL. Biochimie du peroxysome, inflammation et métabolisme lipidique [Dijon] [BIO-PEROXIL], Centre de recherche sur l'Inflammation [CRI (UMR_S_1149 / ERL_8252 / U1149)], Unité de génétique et biologie des cancers [U830], Laboratoire d'Optique et Biosciences [LOB], Institut des Maladies Métaboliques et Casdiovasculaires [UPS/Inserm U1297 - I2MC], Différenciation et communication neuronale et neuroendocrine [DC2N], Institut de Recherche en Cancérologie de Montpellier [IRCM - U1194 Inserm - UM], Centre d'Immunologie de Marseille - Luminy [CIML], Physiopathologie et imagerie des troubles neurologiques [PhIND], Laboratory of Fundamental and Applied Bioenergetics = Laboratoire de bioénergétique fondamentale et appliquée [LBFA], Imagine - Institut des maladies génétiques (IHU) [Imagine - U1163], Institut Mondor de Recherche Biomédicale [IMRB], Franco-czech Laboratory for clinical research on obesity, University of Michigan [Ann Arbor], University of Michigan System, Institut de pharmacologie moléculaire et cellulaire (IPMC), Centre National de la Recherche Scientifique (CNRS)-Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015 - 2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015 - 2019) (COMUE UCA)-Université Côte d'Azur (UCA), Lipides - Nutrition - Cancer [Dijon - U1231] (LNC), Université de Bourgogne (UB)-Institut National de la Santé et de la Recherche Médicale (INSERM)-AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement, Centre méditerranéen de médecine moléculaire (C3M), Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015 - 2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015 - 2019) (COMUE UCA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Côte d'Azur (UCA), Institut de Biologie Valrose (IBV), COMUE Université Côte d'Azur (2015 - 2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015 - 2019) (COMUE UCA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Côte d'Azur (UCA)-Centre National de la Recherche Scientifique (CNRS), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Sud - Paris 11 (UP11), Centre de Recherche des Cordeliers (CRC (UMR_S_1138 / U1138)), École pratique des hautes études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Université de Paris (UP), Université Paris-Sud - Paris 11 (UP11)-Institut National de la Santé et de la Recherche Médicale (INSERM)-AP-HP Hôpital Bicêtre (Le Kremlin-Bicêtre), Nutrition, Métabolisme, Aquaculture (NuMéA), Université de Pau et des Pays de l'Adour (UPPA)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Institut Cochin (IC UM3 (UMR 8104 / U1016)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), Institut NeuroMyoGène (INMG), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM), Paris-Centre de Recherche Cardiovasculaire (PARCC - UMR-S U970), Hôpital Européen Georges Pompidou [APHP] (HEGP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Paris (UP), Institut de Recherche sur le Cancer et le Vieillissement (IRCAN), COMUE Université Côte d'Azur (2015 - 2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015 - 2019) (COMUE UCA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Côte d'Azur (UCA), Centre des Sciences du Goût et de l'Alimentation [Dijon] (CSGA), Université de Bourgogne (UB)-AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Université Bourgogne Franche-Comté [COMUE] (UBFC), Centre de Recherche en Cancérologie de Marseille (CRCM), Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut Paoli-Calmettes, Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Aix Marseille Université (AMU), Centre for Integrative Biology - CBI (Inserm U964 - CNRS UMR7104 - IGBMC), Université de Strasbourg (UNISTRA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institute of genetics and molecular and cellular biology-Centre National de la Recherche Scientifique (CNRS), Chemistry, Oncogenesis, Stress and Signaling (COSS), Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-CRLCC Eugène Marquis (CRLCC)-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut Necker Enfants-Malades (INEM - UM 111 (UMR 8253 / U1151)), Unité de Nutrition Humaine (UNH), Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Clermont Auvergne (UCA), Institut de Biologie Intégrative de la Cellule (I2BC), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Microbes, Intestin, Inflammation et Susceptibilité de l'Hôte (M2iSH), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre de Recherche en Nutrition Humaine d'Auvergne (CRNH d'Auvergne)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Clermont Auvergne (UCA), Institut des Maladies Neurodégénératives [Bordeaux] (IMN), Université de Bordeaux (UB)-Centre National de la Recherche Scientifique (CNRS), Centre International de Recherche en Infectiologie - UMR (CIRI), École normale supérieure - Lyon (ENS Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Centre de Recherches en Cancérologie de Toulouse (CRCT), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Physiologie et Génomique des Poissons (LPGP), Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay, Centre d’Infection et d’Immunité de Lille - INSERM U 1019 - UMR 9017 - UMR 8204 (CIIL), Institut Pasteur de Lille, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille)-Centre National de la Recherche Scientifique (CNRS), Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA), Laboratoire Bio-PeroxIL. Biochimie du peroxysome, inflammation et métabolisme lipidique [Dijon] (BIO-PEROXIL), Université de Bourgogne (UB)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Bourgogne Franche-Comté [COMUE] (UBFC), Centre de recherche sur l'Inflammation (CRI (UMR_S_1149 / ERL_8252 / U1149)), Institut Jean-Pierre Bourgin (IJPB), AgroParisTech-Université Paris-Saclay-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Unité de génétique et biologie des cancers (U830), Institut Curie [Paris]-Institut National de la Santé et de la Recherche Médicale (INSERM), Laboratoire d'Optique et Biosciences (LOB), École polytechnique (X)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Institut des Maladies Métaboliques et Cardiovasculaires (I2MC), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM), Différenciation et communication neuronale et neuroendocrine (DC2N), Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut de Recherche en Cancérologie de Montpellier (IRCM - U1194 Inserm - UM), CRLCC Val d'Aurelle - Paul Lamarque-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM), Centre d'Immunologie de Marseille - Luminy (CIML), Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Physiopathologie et imagerie des troubles neurologiques (PhIND), Université de Caen Normandie (UNICAEN), Laboratory of Fundamental and Applied Bioenergetics = Laboratoire de bioénergétique fondamentale et appliquée (LBFA), Université Grenoble Alpes (UGA)-Institut National de la Santé et de la Recherche Médicale (INSERM), Epithelial biology and disease - Liliane Bettencourt Chair of Developmental Biology (Equipe Inserm U1163), Imagine - Institut des maladies génétiques (IHU) (Imagine - U1163), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Paris (UP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Paris (UP), Biomécanique cellulaire et respiratoire (BCR), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12)-Centre National de la Recherche Scientifique (CNRS), Charles University [Prague]-Institut National de la Santé et de la Recherche Médicale (INSERM), This work was supported by the National Institute of General Medical Sciences [GM131919]., Université Paris-Sud - Paris 11 (UP11)-Institut National de la Santé et de la Recherche Médicale (INSERM), Marqueurs cardiovasculaires en situation de stress (MASCOT (UMR_S_942 / U942)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Groupe Hospitalier Saint Louis - Lariboisière - Fernand Widal [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP)-Université Sorbonne Paris Nord, Université de Strasbourg (UNISTRA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Physiopathologie des Adaptations Nutritionnelles (PhAN), Université de Nantes (UN)-Institut National de la Recherche Agronomique (INRA), Département Plateforme (PF I2BC), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Institut Gustave Roussy (IGR), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO), Chinese Academy of Medical Sciences [Suzhou, Chine] (CAMS), Karolinska Institutet [Stockholm], Karolinska University Hospital [Stockholm], Department of Women's and Children's Health [Stockholm, Sweden], Centre National de la Recherche Scientifique (CNRS)-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille)-Université de Lille-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut Pasteur de Lille, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP), Université de Strasbourg (UNISTRA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-École polytechnique (X), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées, FHU OncoAge - Pathologies liées à l’âge [CHU Nice] (OncoAge), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Côte d'Azur (UCA)-Institut de Pharmacologie Moléculaire et Cellulaire [UNIV Côte d'Azur] (UPMC), Institut Universitaire du Cancer de Toulouse - Oncopole (IUCT Oncopole - UMR 1037), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-CHU Toulouse [Toulouse]-Institut National de la Santé et de la Recherche Médicale (INSERM), Life Sciences Institute [Ann Arbor, MI, USA], University of Michigan System-University of Michigan System, European Institute of Oncology IRCCS [Milan, Italy] (EIO), Ain Shams University (ASU), Johannes Gutenberg - Universität Mainz = Johannes Gutenberg University (JGU), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Université Paris Cité (UPCité), Réseau International des Instituts Pasteur (RIIP), Leibniz Institute of Plant Biochemistry (IPB), Hebrew University of Jerusalem, Université Nice Sophia Antipolis (1965 - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Centre National de la Recherche Scientifique (CNRS)-Université Côte d'Azur (UCA), Université de Bourgogne (UB)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut Agro Dijon, Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Côte d'Azur (UCA), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Côte d'Azur (UCA), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Paris-Centre de Recherche Cardiovasculaire (PARCC (UMR_S 970/ U970)), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité)-Université Sorbonne Paris Nord, Aix Marseille Université (AMU)-Institut Paoli-Calmettes, Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Oncogenesis, Stress, Signaling (OSS), Institut des Maladies Métaboliques et Casdiovasculaires (UPS/Inserm U1297 - I2MC), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Grenoble Alpes (UGA), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité), Institut Mondor de Recherche Biomédicale (IMRB), Institut National de la Santé et de la Recherche Médicale (INSERM)-IFR10-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), Charles University [Prague] (CU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Klionsky, D. 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D., Zhang, H., Zhang, H. -L., Zhang, J., Zhang, J. -P., Zhang, K. Y. B., Zhang, L. W., Zhang, L., Zhang, M., Zhang, P., Zhang, S., Zhang, W., Zhang, X., Zhang, X. -W., Zhang, X. D., Zhang, Y., Zhang, Y. -D., Zhang, Y. -Y., Zhang, Z., Zhao, H., Zhao, L., Zhao, S., Zhao, T., Zhao, X. -F., Zhao, Y., Zheng, G., Zheng, K., Zheng, L., Zheng, S., Zheng, X. -L., Zheng, Y., Zheng, Z. -G., Zhivotovsky, B., Zhong, Q., Zhou, A., Zhou, B., Zhou, C., Zhou, G., Zhou, H., Zhou, J., Zhou, K., Zhou, R., Zhou, X. -J., Zhou, Y., Zhou, Z. -Y., Zhou, Z., Zhu, B., Zhu, C., Zhu, G. -Q., Zhu, H., Zhu, W. -G., Zhu, Y., Zhuang, H., Zhuang, X., Zientara-Rytter, K., Zimmermann, C. M., Ziviani, E., Zoladek, T., Zong, W. -X., Zorov, D. B., Zorzano, A., Zou, W., Zou, Z., Zuryn, S., Zwerschke, W., Brand-Saberi, B., Dong, X. C., Kenchappa, C. S., Lin, Y., Oshima, S., Rong, Y., Sluimer, J. C., Stallings, C. L., Tong, C. -K., and Centre National de la Recherche Scientifique (CNRS)
Subjects: 0301 basic medicine, Programmed cell death, Settore BIO/06, Autophagosome, Autolysosome, [SDV]Life Sciences [q-bio], lnfectious Diseases and Global Health Radboud Institute for Molecular Life Sciences [Radboudumc 4], Autophagy-Related Proteins, Review, Computational biology, [SDV.BC]Life Sciences [q-bio]/Cellular Biology, Biology, Settore MED/04, 03 medical and health sciences, stress, Chaperone-mediated autophagy, ddc:570, Autophagy, LC3, Animals, Humans, cancer, Settore BIO/10, flux, lysosome, macroautophagy, neurodegeneration, phagophore, vacuole, Set (psychology), Molecular Biology, 030102 biochemistry & molecular biology, business.industry, Interpretation (philosophy), Autophagosomes, Cell Biology, Multicellular organism, 030104 developmental biology, Knowledge base, Biological Assay, Lysosomes, business, Biomarkers, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Abstract: Contains fulltext : 232759.pdf (Publisher’s version ) (Closed access) In 2008, we published the first set of guidelines for standardizing research in autophagy. Since then, this topic has received increasing attention, and many scientists have entered the field. Our knowledge base and relevant new technologies have also been expanding. Thus, it is important to formulate on a regular basis updated guidelines for monitoring autophagy in different organisms. Despite numerous reviews, there continues to be confusion regarding acceptable methods to evaluate autophagy, especially in multicellular eukaryotes. Here, we present a set of guidelines for investigators to select and interpret methods to examine autophagy and related processes, and for reviewers to provide realistic and reasonable critiques of reports that are focused on these processes. These guidelines are not meant to be a dogmatic set of rules, because the appropriateness of any assay largely depends on the question being asked and the system being used. Moreover, no individual assay is perfect for every situation, calling for the use of multiple techniques to properly monitor autophagy in each experimental setting. Finally, several core components of the autophagy machinery have been implicated in distinct autophagic processes (canonical and noncanonical autophagy), implying that genetic approaches to block autophagy should rely on targeting two or more autophagy-related genes that ideally participate in distinct steps of the pathway. Along similar lines, because multiple proteins involved in autophagy also regulate other cellular pathways including apoptosis, not all of them can be used as a specific marker for bona fide autophagic responses. Here, we critically discuss current methods of assessing autophagy and the information they can, or cannot, provide. Our ultimate goal is to encourage intellectual and technical innovation in the field.
Published: 2021

12. Dual digital watermarking for internet media based on hybrid strategies

Author: Lin, Pei-Yu, Lee, Jung-San, and Chang, Chin-Chen
Subjects: Interactive computer systems -- Properties, Interactive media -- Properties, Signal processing -- Methods, Image processing -- Methods, Interactive technology, Digital signal processor, Business, Computers, Electronics, Electronics and electrical industries
Published: 2009

13. How online vendors select parcel delivery carriers

Author: Lin, Pei-Chun and Lee, Chia-Hui
Subjects: Customer relations -- Social aspects, Trucking -- Market research -- Social aspects, Lumber industry -- Market research -- Social aspects, Internet -- Social aspects, Transportation authorities -- Social aspects, Electronic commerce -- Market research -- Social aspects, Logistics services -- Market research -- Social aspects, Decision-making -- Social aspects, Labeling-machines -- Market research -- Social aspects, Sales management -- Social aspects, Transportation industry -- Market research -- Social aspects, Marketing research -- Social aspects, Employees -- Beliefs, opinions and attitudes, Online auctions -- Market research -- Social aspects, Business, Transportation industry, Electronic commerce, Marketing research, Online auction, Sales management, Internet, Market research, Social aspects
Abstract: Abstract This study investigated what criteria online vendors use to select parcel delivery carriers and examines what bearing they have on the development and maintenance of mutually beneficial partnerships. The [...]
Published: 2009

14. Optimal pricing, production rate, and quality under learning effects

Author: Lin, Pei-Chun
Subjects: Pricing -- Analysis, Management science -- Analysis, Product price, Business, Business, general
Abstract: To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.jbusres.2007.11.008 Byline: Pei-Chun Lin Keywords: Optimal pricing; Sales rate; Profit system; Revised profit model Abstract: This study investigates the marketing and production problem for a monopolist firm where price, quality and production rate are simultaneous dynamic decision variables under the condition of a dynamic demand that depends on price, quality and cumulative sales. The formulated continuous profit maximization model follows the steps for dynamic optimization to derive optimal price, quality and production policies, wherein a unit production cost that decreases with cumulative production reflects the cost learning effect. Through the differentiable multiplicatively separable demand function, this study analyzes optimal trajectories for determining price, quality, and production rate. The results specify several optimal policies and policy makers would gain insight into the consequence of their decisions that otherwise might have been obscured by sub-optimal analysis. Author Affiliation: National Cheng Kung University, Department of Transportation and Communication Management Science, 701, Taiwan Article History: Received 1 March 2007; Revised 1 August 2007; Accepted 1 November 2007 Article Note: (footnote) [star] The author gratefully acknowledges the helpful comments of the editor and the reviewers. This work was supported in part by the National Science Council of the Republic of China in Taiwan under grants NSC 93-2213-E-327-011.
Published: 2008

15. Protective effect of goserelin on ovarian reserve during (neo)adjuvant chemotherapy in young breast cancer patients: a prospective cohort study in China

Author: Siyuan Wang, Lin Pei, Shu Wang, Taobo Hu, and Mei Jia
Subjects: Oncology, Adult, Anti-Mullerian Hormone, medicine.medical_specialty, China, Adolescent, Breast Neoplasms, 03 medical and health sciences, Young Adult, 0302 clinical medicine, Breast cancer, Ovarian Follicle, Internal medicine, medicine, Clinical endpoint, Humans, Prospective Studies, Prospective cohort study, Ovarian reserve, Ovarian Reserve, 030219 obstetrics & reproductive medicine, biology, business.industry, Rehabilitation, Goserelin, Ovary, Obstetrics and Gynecology, Anti-Müllerian hormone, Middle Aged, Antral follicle, medicine.disease, Chemotherapy regimen, Reproductive Medicine, Chemotherapy, Adjuvant, 030220 oncology & carcinogenesis, biology.protein, Female, business, medicine.drug
Abstract: STUDY QUESTION Does goserelin, a GnRH agonist, have a protective effect in young breast cancer patients in terms of ovarian reserve markers anti-Müllerian hormone (AMH) and antral follicle count (AFC) during chemotherapy? SUMMARY ANSWER Compared with chemotherapy alone, concurrent goserelin is associated with a higher probability of ovarian reserve recovery at 1 year after chemotherapy. WHAT IS KNOWN ALREADY Previous studies on the administration of goserelin to protect ovarian function during chemotherapy have produced conflicting results because of the endpoint used, namely, chemotherapy-induced amenorrhoea. Reproductive medicine specialists consider AMH and AFC as the most sensitive ovarian reserve markers; however, they have never been used as biomarkers to assess the potential protective effects on ovarian reserve of goserelin during chemotherapy. STUDY DESIGN, SIZE, DURATION This was a prospective cohort study in which patients were assigned to receive (neo)adjuvant chemotherapy with goserelin (the goserelin group) or without goserelin (the control group) according to each patient’s preference. Of 242 breast cancer patients enrolled between December 2015 and November 2019, 76 in control group and 73 in goserelin group were able to be assessed at 1 year after chemotherapy. PARTICIPANTS/MATERIALS, SETTING, METHODS Premenopausal patients with a regular menstrual cycle and aged 18–45 years were eligible for enrolment if they were newly diagnosed with stages I–III breast cancer for which treatment with adjuvant or neoadjuvant chemotherapy was planned. Each patient in the goserelin group was given a subcutaneous dose of 3.6 mg at least 1 week before the first cycle of chemotherapy and then every 4 weeks for the duration of chemotherapy. Ovarian reserve markers and menstrual status were evaluated before and after chemotherapy in the two treatment groups. The primary endpoint was the AMH recovery rate, the secondary endpoints were the recovery rates of AFC, estradiol (E2), follicle-stimulating hormone (FSH) and menstruation. MAIN RESULTS AND THE ROLE OF CHANCE Among 149 patients (76 in the control group and 73 in the goserelin group) with complete data at 1 year after chemotherapy, the adjusted recovery rate of AMH was 46.5% and 21.8% in the goserelin group and control group, respectively (odds ratio: 3.08; P = 0.002). The trends in AFC and FSH recovery rates were consistent with that in AMH recovery rate. Notably, AMH levels remained low in 41.3% of patients whose menstrual activity had resumed. LIMITATIONS, REASONS FOR CAUTION Randomisation was not performed because of ethical considerations, so selection bias was inevitable, although propensity score weighting was done. The study was also underpowered because 21.5% (52/242) of enrolled patients received GnRH agonist-containing endocrine therapy and could not be analysed at 1 and 2 years after chemotherapy. WIDER IMPLICATIONS OF THE FINDINGS Our results indicate that co-administration of goserelin with chemotherapy provides obvious ovarian reserve protection in these young breast cancer patients. We expect that these results will be applicable in clinical practice for young breast cancer patients. STUDY FUNDING/COMPETING INTEREST(S) This study was funded by the National Key R&D Program of China No. 2016YFC0901302, by the Research and Development Fund of Peking University People’s Hospital No. RD2014-13, RDY2017-19 and by AstraZeneca. The authors have no disclosures. TRIAL REGISTRATION NUMBER NCT02430103.
Published: 2020

16. Nelumbo nucifera Gaertn Stems (Hegeng) Improved Depression Behavior in CUMS Mice by Regulating NCAM and GAP-43 Expression

Author: Li Chu, Shu-Ning Liu, Ya-Nan Zhao, Shao-Kun Qin, Lin Pei, Ya-Fei Cao, Xin Ping, Yan-Hong Zhang, Sun Guoqiang, and Ye Lu
Subjects: 0303 health sciences, Fluoxetine, Article Subject, Mental symptoms, business.industry, Nelumbo nucifera, Traditional Chinese medicine, Pharmacology, Other systems of medicine, 03 medical and health sciences, 0302 clinical medicine, Complementary and alternative medicine, Mild stress, Antidepressant, Medicine, Neural cell adhesion molecule, business, RZ201-999, 030217 neurology & neurosurgery, Depression (differential diagnoses), 030304 developmental biology, medicine.drug, Research Article
Abstract: Background. Nelumbo nucifera Gaertn stem (Hegeng [HG]) is a traditional Chinese medicine that is used to treat mental symptoms in East Asia. However, scientific evidence is generally lacking to support this traditional claim. Aim of the Study. This study’s aim is to investigate the antidepression effect of HG and to further explore the possible molecular mechanisms that are involved in its actions. Materials and Methods. HG aqueous extract was administered intragastrically for 21 days after the chronic unpredictable mild stress (CUMS) procedure, and its effect on memory, learning, and emotion was assessed using animal behavioral tests. HG aqueous extract was characterized using HPLC. Immunofluorescence was used to measure the neural cell-adhesion molecule (NCAM) and growth-associated protein-43 (GAP-43) expression. Results. Depression-like behaviors increased in the CUMS group compared with the control (CON) group, while they were reduced in the high-dose HG (H-HG) and fluoxetine (FLU) groups (p<0.05). Additionally, NCAM and GAP-43 expression was reduced in the CUMS group compared with the CON group, but it increased in the H-HG and FLU groups (p<0.05). Conclusions. These findings show the potential antidepressant effects of HG through mechanisms involving regulation of NCAM and GAP-43. This provides a new theoretical basis for its potential application as an antidepressant-like agent.
Published: 2020

17. Serum Calcium is a New Indicator to Evaluate Metabolic Syndrome in Hepatocellular Cancer

Author: Lin-Lin Cao, Zhihong Yue, Jiahui Cai, Hui Wang, Mei Jia, and Lin Pei
Subjects: Blood Glucose, Male, medicine.medical_specialty, Cirrhosis, Carcinoma, Hepatocellular, chemistry.chemical_element, Calcium, Gastroenterology, General Biochemistry, Genetics and Molecular Biology, Internal medicine, medicine, Distribution (pharmacology), Humans, Aged, Metabolic Syndrome, Corrected calcium, Hepatocellular cancer, business.industry, Confounding, Liver Neoplasms, Middle Aged, medicine.disease, Corrected Serum Calcium, Lipids, chemistry, Female, Metabolic syndrome, business
Abstract: Background The role of serum calcium in hepatocellular cancer (HCC) patients with features of metabolic syndrome (MetS) is largely unknown. This study aimed to determine the association of serum calcium with clinical features, and the correlation between serum calcium and metabolic parameters, including serum fasting plasma glucose (FPG) and lipids, in HCC patients. Methods The study included 180 HCC patients. Unpaired t-test and covariance analysis were performed to evaluate the distribution of serum calcium among different categorical variables. Simple correlation analyses and partial correlation analyses were conducted to assess the correlations between serum calcium and metabolic parameters. Results HCC patients with cirrhosis had significantly lower total serum calcium than those without cirrhosis, and patients with distant metastasis had significantly higher corrected calcium than their counterparts after adjusting for confounders. Significant correlations between total calcium and metabolic parameters were observed in HCC patients, and these correlations were still significant after adjusting for cirrhosis and distant metastasis. However, the corrected serum calcium showed no significant correlation with metabolic parameters. Conclusions Serum calcium, especially total serum calcium, might be a more sensitive indicator for metabolic syndrome in HCC patients than FPG and lipids.
Published: 2020

18. Novel classifiers with clinical laboratory parameters for early detection of osteosarcoma

Author: Mei Jia, Lin Pei, Lin-Lin Cao, Hui Wang, Tingting Li, Zhihong Yue, and Zhaoming Chen
Subjects: Adult, Male, 0301 basic medicine, Microbiology (medical), Oncology, medicine.medical_specialty, Adolescent, diagnosis, Clinical Biochemistry, Early detection, Bone Neoplasms, Logistic regression, Sensitivity and Specificity, Metastasis, Young Adult, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, Biomarkers, Tumor, medicine, Humans, Immunology and Allergy, Child, Early Detection of Cancer, Research Articles, classifier, Osteosarcoma, Receiver operating characteristic, business.industry, Biochemistry (medical), Public Health, Environmental and Occupational Health, Reproducibility of Results, Hematology, Alkaline Phosphatase, medicine.disease, Medical Laboratory Technology, 030104 developmental biology, ROC Curve, Bone lesion, Case-Control Studies, 030220 oncology & carcinogenesis, Healthy individuals, Female, laboratory parameter, business, Validation cohort, Research Article
Abstract: Background Osteosarcoma (OS) is one of the most common malignant bone tumors. It is essential to explore early diagnostic indicators with high sensitivity and specificity due to the rapid progression and metastasis of OS and the poor survival of metastatic OS patients. However, a few indicators of diagnostic significance have been described. Methods A total of 458 OS patients, 312 healthy individuals, and 228 patients with primary benign bone lesions were included. Logistic regression was performed on 46 clinical laboratory parameters to establish the diagnostic classifiers, which were evaluated by analysis of the receiver operating characteristic (ROC) curves. Results We established three diagnostic classifiers, called C os for all ages, C los for low ages, and C hos for high ages, with clinical laboratory parameters to distinguish OS from healthy individuals. All classifiers showed better diagnostic performances than alkaline phosphatase (ALP) in the independent validation cohort. In addition, these classifiers had better ability than ALP to discriminate OS from primary benign bone lesions. Furthermore, C os, C los, and C hos had larger AUC than ALP to identify small‐size and early‐stage OS and could also detect ALP‐negative OS effectively. Conclusion Our study suggests the potential of C os, C los, and C hos as non‐invasive biomarkers for early OS.
Published: 2020

19. Magnetic torque compensating methods for cam indexing devices

Author: Huang, Kuang-Yuh, Lin, Pei-Chuan, and Tsai, Sheng-Fu
Subjects: Finite element method -- Usage, Magnetic devices -- Design and construction, Functional analysis -- Usage, Torque -- Measurement, Business, Electronics, Electronics and electrical industries
Abstract: In automatic production processes, cam indexing devices are frequently utilized to transport workpieces intermittently to the appointed manufacturing positions. However, because of alternating working forces and rotational inertia, indexing devices tend to generate vibration during each positioning process, which retards working speed and degrades positioning accuracy. To minimize positioning vibration, we developed a magnetic compensation concept and diverse devices based on the concept. A magnetic torque compensator basically consists of a magnetic loop with field generator and soft-magnetic elements. The soft-magnetic elements are designed to generate relative motion to each other to realize variable distribution of magnetic field and induce a compensation torque to suppress the positioning vibration. In addition to our experimental research, we investigated analytically the influential parameters of the compensating torque and their relationships by using the equivalent magnetic circuit method and the finite-element method. We found that modifications of magnetic arrangement or geometric parameters of functional elements lead to different characteristics of the magnetic torque curve. On the basis of the verified function and parameters of the magnetic torque compensator, we built some configurations to synthesize the compensating torque needed for countering vibration. Index Terms--Functional analysis, magnetic device, motion compensation, torque control.
Published: 2007

20. Targeted Sequencing of Circulating Tumor DNA to Monitor Genetic Variants and Therapeutic Response in Metastatic Colorectal Cancer

Author: Chien Yuh Yeh, Hung-Chih Hsu, Chuang-Wei Wang, Tsai Sheng Yang, Hsin Yuan Hung, Lin Pei-Yi, Shu-Jen Chen, Sum-Fu Chiang, Nina Lapke, Jeng Fu You, An Hsu, Wen-Sy Tsai, and Hua-Chien Chen
Subjects: Adult, Male, 0301 basic medicine, Oncology, Cancer Research, medicine.medical_specialty, Colorectal cancer, Circulating Tumor DNA, Young Adult, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, Antineoplastic Combined Chemotherapy Protocols, Biomarkers, Tumor, Humans, Medicine, Neoplasm Metastasis, Objective response, Aged, Neoplasm Staging, Predictive biomarker, Aged, 80 and over, business.industry, Tumor shrinkage, Genetic variants, Genetic Variation, High-Throughput Nucleotide Sequencing, Middle Aged, Disease monitoring, medicine.disease, Treatment Outcome, 030104 developmental biology, Circulating tumor DNA, 030220 oncology & carcinogenesis, Biomarker (medicine), Female, Colorectal Neoplasms, Tomography, X-Ray Computed, business
Abstract: Substantial improvements have been made in the management of metastatic colorectal cancer (mCRC) in the last two decades, but disease monitoring remains underdeveloped. Circulating tumor DNA (ctDNA) is a promising prognostic and predictive biomarker; however, ctDNA as a marker for mCRC patients is not well established, and there is still no consensus about how to utilize it most cost-effectively. In this study, we aim to investigate plasma ctDNA levels as a biomarker for therapeutic response of mCRC patients. We performed next-generation sequencing (NGS) by using a 12-gene panel to identify genetic variants in 136 tumor tissue and ctDNA samples from 32 mCRC patients. Genetic variants were detected in approximately 70% of samples, and there was a high concordance (85%) between tumor tissue and plasma ctDNA. We observed ctDNA changes in 18 follow-up patients, including the emergence of new variants. Changes in ctDNA levels significantly correlated with tumor shrinkage (P = 0.041), and patients with a ctDNA decrease >80% after treatment had a longer progression-free survival compared with patients with a ctDNA decrease of 80% was better than those with a ctDNA decrease
Published: 2018

21. The Effect of Limiting Tapioca Milk Tea on Added Sugar Consumption In Taiwanese Young Male and Female Subjects

Author: Hitomi Takeichi, Jia Yau Doong, Wen Lee Chen, Indri Kartiko Sari, Sumiko Kamoshita, Ying Lin Pei, Shigeru Yamamoto, Ting Chun Chen, and Fang Yu Lin
Subjects: Adult, Male, 0301 basic medicine, sugar intake, Sucrose, food habit, Taiwan, 030209 endocrinology & metabolism, Added sugar, General Biochemistry, Genetics and Molecular Biology, Young Adult, 03 medical and health sciences, chemistry.chemical_compound, tapioca milk tea, 0302 clinical medicine, Sugar intake, Animals, Humans, Medicine, Food science, Lactose, Sugar, Young male, 030109 nutrition & dietetics, Tea, business.industry, food and beverages, Fructose, General Medicine, Limiting, Milk, chemistry, Female, Sugars, business
Abstract: Tapioca milk tea, the most popular beverage in Taiwan, is consumed a lot by Taiwanese which contributed to their daily sugar intake. Our study purpose is to investigate whether limiting intake of tapioca milk tea is useful for the control of sugar intake in Taiwanese. The study was conducted in questionnaires selected 38 subjects, 20-24 y, from 341 university students in Kaohsiung City, Taiwan. Subjects were match-paired by sex, age, department, and randomly divided into two groups for cross-over design in which each group had 1 week with or without tapioca milk tea. Other beverages and foods were allowed freely in both periods. Each group member recorded their own daily sugary intake for two weeks and was confirmed by researchers the next day. The average sugar intakes with or without tapioca milk tea were similar between the two treatments (p 0.05), 58.4 23.2 g/day and 56.5 22.2 g/day (glucose 25%, fructose 19%, sucrose 53%, lactose 3%). With or without tapioca milk tea, 85% of sugar intakes came from beverages. Even by limiting tapioca milk tea, the subjects took the same sugar amount from other beverages, suggesting that an established sugar intake level is hard to change. J. Med. Invest. 65:43-49, February, 2018.
Published: 2018

22. Identify the susceptibility profile to measles in the general population: Serological survey of measles antibodies in Shaanxi province, China, in 2016

Author: Shaobai Zhang, Xiaodan Zhao, Lin Pei, Yuxuan Yang, Lingyun Yuan, Yan Yu, and Yamei Liu
Subjects: Male, Pediatrics, Vaccination Coverage, Antibodies, Viral, Serology, 0302 clinical medicine, Seroepidemiologic Studies, Mass Screening, Medicine, 030212 general & internal medicine, Child, education.field_of_study, Incidence, Incidence (epidemiology), Vaccination, Middle Aged, Infectious Diseases, Child, Preschool, Molecular Medicine, Female, Disease Susceptibility, Adult, China, medicine.medical_specialty, Adolescent, Measles Vaccine, Population, 030231 tropical medicine, Measles, Young Adult, 03 medical and health sciences, Humans, Seroprevalence, education, Mass screening, General Veterinary, General Immunology and Microbiology, business.industry, Infant, Newborn, Public Health, Environmental and Occupational Health, Infant, medicine.disease, Cross-Sectional Studies, Immunoglobulin G, Immunology, Measles vaccine, business
Abstract: The reported coverage with two doses of the measles vaccine (MCV) in Shaanxi Province, China, is greater than 95%, but the measles incidence over the whole province remains high. Cross-sectional serological surveys of measles antibodies in Shaanxi Province were conducted in 2016 to assess the population's immunity. The measles IgG levels were measured in serum samples using ELISA. The geometric means concentration (GMC) levels and seroprevalence rates with 95% CIs were calculated by region, gender, and age. A total of 3574 serum samples were collected from participants aged from 2 months to 49 years. The GMC of measles antibodies was 471.3 mIU/ml (95% CI: 445.9-498.2 mIU/ml), and the seroprevalence was only 85.9% (95% CI: 84.8-87.1%). A significant difference in the GMC (P .05) but not the seroprevalence (P .05) was observed among the 3 regions. The report measles incidences were high in individuals aged 0-7 months (33.2/100 000) and 8-17 months (26.8/100 000). Although both measles immunity (90.7%) and MCV coverage (89.7%) were low in children aged 8-17 months, the measles seroprevalence in adults was high at greater than 90%. These results revealed that further actions may be taken to increase vaccination coverage in children aged 8 months to 5 years over the whole province and teenagers in the south region. In particular, timely administration of the first MCV dose should be emphasized to prevent measles epidemics in children aged 8-17 months. Vaccination strategies may be varied by age and region.
Published: 2017

23. Baicalin promotes hippocampal neurogenesis via the Wnt/β-catenin pathway in a chronic unpredictable mild stress-induced mouse model of depression

Author: Lin Pei, Sun Guoqiang, Ye Lu, Zhigang Xiao, Zhuoqing Cao, Yuru Du, Jiali Yang, and Zhixia Jia
Subjects: Male, 0301 basic medicine, Doublecortin Protein, Neurogenesis, Pharmacology, Hippocampal formation, Hippocampus, Biochemistry, Neuroprotection, Mice, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Animals, Medicine, Wnt Signaling Pathway, Flavonoids, Mice, Inbred ICR, biology, Depression, business.industry, Dentate gyrus, Anti-Inflammatory Agents, Non-Steroidal, Wnt signaling pathway, Antidepressive Agents, Doublecortin, 030104 developmental biology, chemistry, 030220 oncology & carcinogenesis, Catenin, biology.protein, business, Baicalin, Stress, Psychological
Abstract: Hippocampal neurogenesis is known to be related to depressive symptoms. Increasing evidence indicates that Wnt/β-catenin signaling regulates multiple aspects of adult hippocampal neurogenesis. Baicalin is a major flavonoid compound with multiple pharmacological effects such as anti-inflammatory, anti-apoptotic, and neuroprotective effects. The current study aimed to explore the antidepressant effects of baicalin and its possible molecular mechanisms affecting hippocampal neurogenesis via the regulation of the Wnt/β-catenin signaling pathway. A chronic mild unpredictable stress (CUMS) model of depression was used in the study. The CUMS-induced mice were treated with baicalin (50 and 100 mg/kg) for 21 days, orally, and the fluoxetine was used as positive control drug. The results indicated that baicalin alleviated CUMS-induced depression-like behaviour, and improved the nerve cells’ survival of the hippocampal dentate gyrus (DG) in CUMS-induced depression of model mice and increased Ki-67- and doublecortin (DCX)-positive cells to restore CUMS-induced suppression of hippocampal neurogenesis. The related proteins in the Wnt/β-catenin signaling pathway, which declined in the CUMS-induced depression model of mice, were upregulated after baicalin treatment, including Wingless3a (Wnt3a), dishevelled2 (DVL2), and β-catenin. Further study found that the phosphorylation rate of glycogen synthase kinase-3β (GSK3β) and β-catenin nuclear translocation increased, as the levels of the β-catenin target genes cyclinD1, c-myc, NeuroD1, and Ngn2 upregulated after baicalin treatment. In conclusion, these findings suggest that baicalin may promote hippocampal neurogenesis, thereby exerting the antidepressant effect via regulation of the Wnt/β-catenin signaling pathway.
Published: 2021

24. Comment on 'The Value of Hepatic Vein Stent Placement as a Bridge Therapy on Treating Hepatic Alveolar Echinococcosis Presenting With Budd-Chiari Syndrome'

Author: Yi-Lin Pei, Jia-Hong Dong, Hao Shang, Xiao-Bin Feng, and Qian lu
Subjects: medicine.medical_specialty, business.industry, medicine.disease, Hepatic Complication, Echinococcosis, Surgery, Stent placement, medicine.anatomical_structure, Bridge (graph theory), Hepatic surgery, medicine, Budd–Chiari syndrome, Vein, business, Hepatic Alveolar Echinococcosis
Published: 2021

25. A longitudinal analysis of the lifetime cost of dementia

Author: Yang, Zhou, Zhang, Kun, Lin, Pei-Jung, Clevenger, Carolyn, and Atherly, Adam
Subjects: Dementia -- Development and progression -- Analysis -- Economic aspects -- Care and treatment, Aged -- Surveys -- Analysis -- Economic aspects -- Health aspects, Medical care, Cost of -- Analysis -- Economic aspects, Business, Health care industry
Abstract: Objective, Estimate the lifetime cost of dementia to Medicare and Medicaid. Data Source, 1997-2005 Medicare Current Beneficiary Survey. Study Design, A multistage analysis was conducted to first predict the probability of developing dementia by age and then predict the annual Medicare/Medicaid expenditures conditional on dementia status. A cohort-based simulation was conducted to estimate the lifetime cost of dementia. Principal Findings. The average lifetime cost of dementia per patient for Medicare is approximately $12,000 (2005 dollars) and for Medicaid about $11,000. Dementia onset at older age leads to shorter duration and lower lifetime cost. Increased educational level leads to longer longevity, more dementia cases per cohort, but shorter duration, and lower lifetime cost per patient, which could offset the cost increase induced by more dementia cases. Increased body mass index leads to more dementia cases per cohort and higher lifetime cost per patient. Conclusion. Net cost of dementia is lower than the estimates from cross-sectional studies. Promoting healthy lifestyle to reverse the obesity epidemic is a short-term priority to confront the epidemic of dementia in the near future. Promoting higher education among the younger generation is a long-term priority to mitigate the effect of population aging on the dementia epidemic in the distant future. Key Words. Health care costs, Medicare, aging/elderly/geriatrics, Dementia has become a major public health challenge for our aging society. Currently, about 5.2 million Americans live with Alzheimer's disease (AD) and other dementias, and the estimated societal cost [...]
Published: 2012
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26. Anticancer Activity of Pterostilbene in Human Ovarian Cancer Cell Lines

Author: Dan-mei Mu, Bin Zhang, and Hui-lin Pei
Subjects: 0301 basic medicine, Oncology, medicine.medical_specialty, Pterostilbene, medicine.medical_treatment, Antineoplastic Agents, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Western blot, Cell Line, Tumor, Internal medicine, Stilbenes, medicine, Humans, Electrophoretic mobility shift assay, Phosphorylation, Extracellular Signal-Regulated MAP Kinases, Molecular Biology, Protein kinase B, Ovarian Neoplasms, medicine.diagnostic_test, Tumor Necrosis Factor-alpha, business.industry, NF-kappa B, Transcription Factor RelA, Cancer, General Medicine, medicine.disease, Gene Expression Regulation, Neoplastic, 030104 developmental biology, Cytokine, chemistry, 030220 oncology & carcinogenesis, Cancer research, Cytokines, Female, Tumor necrosis factor alpha, Ovarian cancer, business, Proto-Oncogene Proteins c-akt
Abstract: BACKGROUND Epithelial ovarian cancer is a major cause of mortality in women and one of the most common gynecologic disorders. Pterostilbene (PTS), a trans-3,5-dimethoxy-4'-hydroxystilbene, was chosen for this work due to its reported effectiveness as a chemotherapeutic agent in cancer studies. In this work, we studied underlying molecular mechanisms of PTS treatment in various ovarian cancer cell lines such as OVCAR8, OV1063, IGROV-1, and SKOV3. MATERIAL AND METHODS We used the cytometric bead array (CBA) method and real-time PCR analysis to analyze the secretion level of tumor necrosis factor alpha (TNF-α) and to measure the TNF-α mRNA expression. NF-kappa B (NF-κB) promoter analysis, Western blot analysis, electrophoresis mobility shift assay (EMSA), and immunostaining analyses were performed to measure the NF-κB activity and other relative proteins levels. RESULTS The PTS treatment decreased the release of TNF-α in IGROV-1 ovarian cancer cells. It also showed significant inhibitory effect on nuclear NF-κB p50, and NF-κB p65 protein levels. CONCLUSIONS From the results obtained, we suggest that PTS has the potential to treat ovarian cancer by reducing the level of TNF-α cytokine and to have a limited effect on NF-κB, AKT, and ERK signaling pathways.
Published: 2017

27. The expression of histone deacetylase HDAC1 correlates with the progression and prognosis of gastrointestinal malignancy

Author: Zhihong Yue, Lin Pei, Jie Zhao, Yue Yin, Lianhua Liu, Lin-Lin Cao, Li Qin, Hui Wang, Mei Jia, and Huixin Liu
Subjects: 0301 basic medicine, medicine.medical_specialty, Pathology, Colorectal cancer, overall survival, Histone Deacetylase 1, Gastroenterology, 03 medical and health sciences, 0302 clinical medicine, Meta-Analysis as Topic, Internal medicine, Biomarkers, Tumor, medicine, Humans, Gastrointestinal cancer, Survival rate, Aged, Gastrointestinal Neoplasms, business.industry, Cancer, gastrointestinal malignancy, Middle Aged, Prognosis, medicine.disease, HDAC1, clinical feature, Survival Rate, meta-analysis, 030104 developmental biology, Oncology, 030220 oncology & carcinogenesis, Meta-analysis, Disease Progression, Cancer biomarkers, Histone deacetylase, business, Research Paper
Abstract: Gastrointestinal malignancy is a severe public health threat worldwide, and survival for most types of gastrointestinal cancer is very poor. Therefore, finding better cancer biomarkers to diagnose gastrointestinal malignancy and predict patient survival is essential. HDAC1 has been reported to be closely associated with several types of cancer, but the precise role of HDAC1 in gastrointestinal cancer is not clear. Recently, quite a few studies have investigated the correlation between HDAC1 expression and clinical features or prognosis in multiple types of gastrointestinal malignancies, but the results were inconsistent. In this study, we systematically reviewed the association between HDAC1 and gastrointestinal malignancy using meta-analysis methods, and 28 eligible studies were analyzed. We found that the expression level of HDAC1 in gastrointestinal malignancies, especially in colorectal cancer (OR = 10.84, 95% CI = 5.33–22.07, P< 0.00001), was higher than that in noncancerous tissue, and HDAC1 expression was closely associated with some clinical features of gastrointestinal cancer patients, such as tumor stage (OR = 1.62, 95% CI = 1.28–2.05, P < 0.0001) and tumor grade (OR = 1.75, 95% CI = 1.03–2.95, P = 0.04). In addition, we also found that patients with low HDAC1 expression showed better overall survival than those with high HDAC1 expression in gastrointestinal malignancy, especially in gastric cancer (HR = 1.88, 95% CI = 1.14–3.12, P = 0.01). Our results strongly suggest that HDAC1 may serve as a good diagnostic and prognostic marker for gastrointestinal malignancy.
Published: 2017

28. Critical factors affecting the adoption of container security service: The shippers' perspective

Author: Chao, Shih-Liang and Lin, Pei-Shan
Subjects: Containers -- Analysis, Business, Business, international, Engineering and manufacturing industries
Abstract: To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.ijpe.2008.12.021 Byline: Shih-Liang Chao, Pei-Shan Lin Keywords: Container shipping; Container security; Extended technology acceptance model; RFID; Structural equation modeling Abstract: After September 11, 2001, a so-called container security service (CSS) composed of auto-detection and radio frequency identification (RFID) technologies has been introduced and commercialized. The objective of this study is to identify the factors affecting intention to adopt the CSS. A novel research model was developed based on the technology acceptance model. Eight hypotheses derived from this model were empirically validated using a questionnaire survey of current users of container transportation and structural equation modeling (SEM). The results suggest that security (SE) strongly effects on the perceived ease of use, attitude and behavioral intention (BI) to adopt the CSS. This implies that system operators should further enhance data security to increase the intention to adopt the CSS. Author Affiliation: Department of Shipping and Transportation Management, National Taiwan Ocean University, 2, Pei-Ning Road, Keelung 20224, Taiwan, ROC Article History: Received 29 June 2008; Accepted 27 December 2008
Published: 2009

29. Baicalin regulates depression behavior in mice exposed to chronic mild stress via the Rac/LIMK/cofilin pathway

Author: Guan Zhenwei, Yongyong Liu, Li Chu, Zui Zhang, Lin Pei, Fan Yang, Sun Guoqiang, Ye Lu, and Jing Zhao
Subjects: 0301 basic medicine, Male, Tropomyosin receptor kinase B, Hippocampus, chemistry.chemical_compound, Mice, 0302 clinical medicine, Neurotrophic factors, Neurons, biology, Behavior, Animal, Depression, Lim Kinases, General Medicine, Cofilin, rac GTP-Binding Proteins, Actin Depolymerizing Factors, 030220 oncology & carcinogenesis, Disks Large Homolog 4 Protein, Rac1, medicine.drug, Signal Transduction, medicine.medical_specialty, Synaptophysin, RM1-950, Synaptic plasticity, 03 medical and health sciences, Internal medicine, medicine, Animals, Receptor, trkB, RNA, Messenger, Baicalin, Swimming, Pharmacology, Flavonoids, Fluoxetine, business.industry, Brain-Derived Neurotrophic Factor, 030104 developmental biology, Endocrinology, chemistry, Chronic Disease, biology.protein, Therapeutics. Pharmacology, business, Postsynaptic density, Stress, Psychological
Abstract: Background: Depression is a common disease that endangers people’s physical and mental health. Traditional Chinese medicine has advantages in treating the emotional and cognitive symptoms of depressive disorders. Objective: To study the effects of baicalin on the behavior and to clarify the underlying mechanism through evaluation of the Rac1-LIMK1-cofilin pathway. Methods: A chronic mild stress (CMS) model of depression was used. Baicalin was administered to the mice for the intervention, and the positive control group was treated with fluoxetine. Behavioral tests were conducted to observe the degree of depressive disorders. Synaptophysin (SYP), postsynaptic density protein-95 (PSD95), brain-derived neurotrophic factor (BDNF), tyrosine kinase receptors (TrkB), Rac1 and cofilin expression was determined using Western blot analysis, and mRNA was quantified using real-time PCR. Results: Mice in the CMS group showed an increase in depression-like behavior (p 0.05). Conclusion: Baicalin markedly alleviated depression-like behavioral changes, exerted effects on SYP, PSD95, BDNF, and TrkB expression, activated the Rac1-cofilin pathway, and subsequently improve synaptic plasticity.
Published: 2019

30. Effect of Self-Invertible Matrix on Cipher Hexagraphic Polyfunction

Author: Faridah Yunos and Sally Lin Pei Ching
Subjects: Computer Networks and Communications, Lucas sequence, Cryptography, 02 engineering and technology, Data_CODINGANDINFORMATIONTHEORY, 01 natural sciences, lcsh:Technology, law.invention, RSA, law, LUC, 0103 physical sciences, Hill cipher, Ciphertext, 0202 electrical engineering, electronic engineering, information engineering, Order (group theory), self-invertible matrix, Hardware_ARITHMETICANDLOGICSTRUCTURES, 010306 general physics, Mathematics, Discrete mathematics, business.industry, lcsh:T, Applied Mathematics, 020202 computer hardware & architecture, Computer Science Applications, Invertible matrix, Computational Theory and Mathematics, Cipher, Data_GENERAL, Key (cryptography), Cipher Polygraphic, business, Software
Abstract: A cryptography system was developed previously based on Cipher Polygraphic Polyfunction transformations, C i &times, j ( t ) &equiv, A i &times, i t P i &times, j m o d N where C i &times, j , P i &times, j , A i &times, i are cipher text, plain text, and encryption key, respectively. Whereas, ( t ) is the number of transformations of plain text to cipher text. In this system, the parameters ( A i &times, i , ( t ) ) are kept in secret by a sender of messages. The security of this system, including its combination with the second order linear recurrence Lucas sequence (LUC) and the Ron Rivest, Adi Shamir and Leonard Adleman (RSA) method, until now is being upgraded by some researchers. The studies found that there is some type of self-invertible A 4 &times, 4 should be not chosen before transforming a plain text to cipher text in order to enhance the security of Cipher Tetragraphic Trifunction. This paper also seeks to obtain some patterns of self-invertible keys A 6 &times, 6 and subsequently examine their effect on the system of Cipher Hexagraphic Polyfunction transformation. For that purpose, we need to find some solutions L 3 &times, 3 for L 3 &times, 3 2 &equiv, A 3 &times, 3 mod N when A 3 &times, 3 are diagonal and symmetric matrices and subsequently implement the key L 3 &times, 3 to get the pattern of A 6 &times, 6 .
Published: 2019

31. Study on the relationship between FFA and gout flare

Author: Lin Pei, Linfeng Xie, Han Zhang, Xuewu Zhang, and Junying Wu
Subjects: Adult, Male, medicine.medical_specialty, Gout, Hyperuricemia, Fatty Acids, Nonesterified, Gastroenterology, Asymptomatic, 03 medical and health sciences, chemistry.chemical_compound, Young Adult, 0302 clinical medicine, Rheumatology, Monosodium urate, Internal medicine, medicine, Humans, 030212 general & internal medicine, Triglycerides, Aged, 030203 arthritis & rheumatology, Aged, 80 and over, Triglyceride, business.industry, Arthritis, Gouty, Significant difference, General Medicine, Cholesterol, LDL, Middle Aged, medicine.disease, Symptom Flare Up, Uric Acid, Serum urate, chemistry, lipids (amino acids, peptides, and proteins), Female, medicine.symptom, business, Biomarkers
Abstract: To detect the serum free fatty acid (FFA) concentration in patients with primary gouty arthritis (GA) and to explore the correlation between FFA and gout flare.Sixty patients with acute GA, 60 patients with GA remission, 60 patients with asymptomatic hyperuricemia (HUA), and 60 normal controls were enrolled in this study. Serum FFA concentration was detected by enzymatic determination in four groups, and the relationship between serum FFA, serum urate (SU), and other clinical and laboratory parameters was analyzed.(1) Serum FFA concentration was significantly higher in the acute GA than in the GA remission, the asymptomatic HUA, and the normal control (H = 72.191, P 0.001). (2) There were no significant difference in serum triglyceride and low-density lipoprotein cholesterol (LDL-C) concentration between the acute GA, the GA remission, the asymptomatic HUA, and the normal control group.FFA may be involved in the acute attack of gout in conditions of monosodium urate crystal deposition in the joints. Triglyceride and LDL-C may not be involved in the acute attack of gout. FFA may be used as an indicator to monitor the status of GA in clinical.Key Points• Lin Pei and Linfeng Xie designed the randomized controlled trial and were responsible for the development of the protocol.
Published: 2019

32. Effects of Huazhuo Jiedu Shugan Decoction on Cognitive and Emotional Disorders in a Rat Model of Epilepsy: Possible Involvement of AC-cAMP-CREB Signaling and NPY Expression

Author: Xin Ping, Ye Lu, Ya-Fei Cao, Lin Pei, Shu-Ning Liu, Ya-Nan Zhao, Shaodan Zhang, Li Chu, Yan-Hong Zhang, and Shao-Kun Qin
Subjects: medicine.medical_specialty, Article Subject, Hippocampus, Brain damage, Traditional Chinese medicine, CREB, 03 medical and health sciences, Epilepsy, chemistry.chemical_compound, 0302 clinical medicine, Internal medicine, medicine, Cyclic adenosine monophosphate, Pentylenetetrazol, 030304 developmental biology, 0303 health sciences, biology, business.industry, lcsh:Other systems of medicine, lcsh:RZ201-999, medicine.disease, Neuropeptide Y receptor, Endocrinology, Complementary and alternative medicine, chemistry, biology.protein, medicine.symptom, business, 030217 neurology & neurosurgery, medicine.drug, Research Article
Abstract: Background. Huazhuo Jiedu Shugan decoction (HJSD), a traditional Chinese medicine (TCM), has been used to treat epileptic seizures for many years. Some ingredients in these herbs have been demonstrated to be effective for the treatment of brain damage caused by epilepsy. Aim of the Study. The object of the study is to determine the effects of HJSD on cognitive and emotional disorders in a rat model of epilepsy. Materials and Methods. After a predetermined time period, rats were intraperitoneally injected with pentylenetetrazol and observed in different phases of convulsions. The cognitive and emotional changes in the epileptic rats were assessed using behavioral and immunohistochemical tests. Results. Compared with the epilepsy group, the seizure grade was reduced and seizure latency was prolonged following HJSD-H treatment (P<0.01). Compared with the control group, the epilepsy group displayed marked worse performance on the animal behavior tests (P<0.05) and the HJSD-H group displayed improved behavioral performance (P<0.05). After HJSD-H treatment, the expression of adenylate cyclase (AC), cyclic adenosine monophosphate (cAMP), cAMP-response element binding protein (CREB), and neuropeptide Y (NPY) immunoreactive cells markedly increased in the hippocampus, compared with that of the epilepsy group (P<0.05). Conclusions. The current results demonstrate that HJSD treatment in epileptic rats markedly inhibits epileptic seizures and improves cognitive and emotional disorders, which may be related to the regulation of AC-cAMP-CREB signaling and NPY expression in the hippocampus. The effects of the HJSD treatment may provide a foundation for the use of HJSD as a prescription medicinal herb in the TCM for the treatment of epilepsy.
Published: 2019
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33. HDD and CDD option pricing with market price of weather risk for Taiwan

Author: Huang, Hung-Hsi, Shiu, Yung-Ming, and Lin, Pei-Syun
Subjects: Options (Finance) -- Valuation, Weather -- Economic aspects, Risk management -- Research, Risk management, Business, Business, general
Abstract: Call prices for heating and cooling degree days in Taiwan are higher, while prices for puts are lower. The effects of mean and standard deviation on weather option prices are the same as those on pricing traditional financial derivatives.
Published: 2008

34. UUO induces lung fibrosis with macrophage-myofibroblast transition in rats

Author: Tatsuo Shimosawa, Xiangting Wang, Hui Li, Yunzhao Xiong, Xuelian Ma, Zheng Wang, Lin Pei, Yi Chang, Fan Yang, Cuijuan Zhang, and Qingyou Xu
Subjects: Male, 0301 basic medicine, Pathology, medicine.medical_specialty, Pulmonary Fibrosis, Immunology, Population, Lung injury, Protective Agents, urologic and male genital diseases, 03 medical and health sciences, 0302 clinical medicine, Fibrosis, Pulmonary fibrosis, medicine, Animals, Humans, Immunology and Allergy, Rats, Wistar, Renal Insufficiency, Chronic, Myofibroblasts, education, Mineralocorticoid Receptor Antagonists, Pharmacology, education.field_of_study, Lung, urogenital system, business.industry, Macrophages, Cell Differentiation, respiratory system, medicine.disease, female genital diseases and pregnancy complications, Eplerenone, Rats, respiratory tract diseases, Disease Models, Animal, 030104 developmental biology, medicine.anatomical_structure, 030220 oncology & carcinogenesis, business, Myofibroblast, Ureteral Obstruction, medicine.drug, Kidney disease
Abstract: Progression of chronic kidney disease (CKD) to uremia is often accompanied by varying degrees of lung damage and this is also an important cause of death. Although there are many studies on the mechanism of lung injury, it is not clearly understood. Inflammatory macrophages may associated with fibrosis in the lungs. Here, we investigated the role of macrophage-myofibroblast transition (MMT) in lung fibrosis with unilateral ureteral obstruction (UUO) rats. We found that cells undergoing MMT accounted for an important part of the myofibroblast population, and correlated with lung fibrosis, MMT cells in lungs have a predominant M2 phenotype, and this process was attenuated after treatment with eplerenone. In conclusion, our studies provide a possible mechanism for UUO-induced kidney damage and lung injury, indicating the possibility of using eplerenone, a mineralocorticoid receptor blocker, to treat UUO to reduce kidney damage and protect lung function.
Published: 2021

35. Determination of price and warranty length for a normal lifetime distributed product

Author: Wu, Chin-Chun, Lin, Pei-Chun, and Chou, Chao-Yu
Subjects: Interest rates, Management science, Business, Business, international, Engineering and manufacturing industries
Abstract: To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.ijpe.2005.02.002 Byline: Chin-Chun Wu (a), Pei-Chun Lin (b), Chao-Yu Chou (a) Keywords: Free renewal; Normal distribution; Price; Profit; Warranty length Abstract: In this paper, a decision model is presented for manufacturing firms to determine the optimal price and warranty length to maximize profits based on the pre-determined life cycle. We consider the free renewal warranty policy under which failed items are renewed free of charge until a specified total operating time has been achieved. The expected number of renewals based on the warranty length is derived for a normal lifetime distributed product and the total cost of production and providing warranty is evaluated. A solution approach using the maximum principle is described, and is applied to two specific types of markets. The first type of market considers the case of static sales rate function with a positive discount rate, and the second type of market considers the case of separable sales rate function with a zero discount rate. A sensitivity analysis is conducted to evaluate the effect of model parameters on the optimal solution. Some conclusions are drawn based on the sensitivity analysis. Author Affiliation: (a) Department of Industrial Engineering and Management, National Yunlin University of Science and Technology, Touliu 640, Taiwan, ROC (b) Department of Transportation and Communication Management Science, National Cheng Kung University, Tainan 701, Taiwan, ROC Article History: Received 23 March 2004; Accepted 3 February 2005
Published: 2006

36. Speaker identification based on a matrix quantization method

Author: Chen, Ming-Shih, Lin, Pei-Hwa, and Wang, Hsiao-Chuan
Subjects: Speech processing systems -- Research, Voice recognition -- Research, Business, Computers, Electronics, Electronics and electrical industries
Abstract: An experimental study on speaker identification is presented. It employs a data base of continous Mandarin digit utterances compiled from 25 male and 25 female speakers. A matrix quantization-based approach is introduced where a matrix is formed from feature vectors obtained from the weighted cepstral coefficients of a block of frames. Results demonstrate attainable identification rates of 100% even for 2-s utterances.
Published: 1993

37. Quantitative Impact and Research on Water Supply Management and Demand in Beijing under the WEAP Model

Author: Keling Liu, Xiaoshi Wu, Meng Hao, Lin Pei, Liangpeng Xiao, Liu Yang, and Qingyi Cao
Subjects: Beijing, business.industry, Environmental science, Water supply, WEAP, Water resource management, business
Abstract: Predicting the future water supply and demand is an important basis for achieving optimal water resource allocation and serves as an effective methodology to solve the imbalances between water supply and demand in cities and achieve long-term stable supply and efficient water resource utilization. In this study, we use the water evaluation and planning (WEAP) model to quantitatively analyze the effects of the water resource policies on the balance between the supply and demand of water resources in Beijing and predict the water demand and shortages in Beijing from 2019 to 2035. The simulation results indicate that at the watershed scale, different levels of water shortage can be observed in the five major watersheds under different scenarios. By 2035, the unmet demand in the Beiyunhe river basin will be the most serious, accounting for ⩾45.48% of the total unmet demand. The policy constraints play a crucial role in alleviating the supply-and-demand imbalance of water resources. Different policies can be used to reduce the total water demand; however, the population growth control policies exhibit the greatest effect on the alleviation of water resource shortage in Beijing and can reduce the water demand by 3.42 million m3 when compared with that in a scenario without any control policy. The results of this study can provide important references to solve the urban water resource supply and demand imbalances and realize rational allocation of the water resources.
Published: 2020

38. Establishment of a Han Chinese-specific pharmacogenetic-guided warfarin dosing algorithm

Author: Wenhui Nan, Mei Jia, Jie Zhang, Lin Pei, Rui Qiao, Yan Long, and Xiaoyi Tian
Subjects: Male, medicine.medical_specialty, China, Pharmacogenomic Variants, CYP4F2, Urology, CYP2C19, 030204 cardiovascular system & hematology, 030226 pharmacology & pharmacy, Polymorphism, Single Nucleotide, Cohort Studies, 03 medical and health sciences, 0302 clinical medicine, Therapeutic index, Asian People, Vitamin K Epoxide Reductases, Medicine, Humans, Cytochrome P450 Family 4, Aged, Dosing algorithm, Maintenance dose, business.industry, Warfarin, Anticoagulants, General Medicine, Middle Aged, Cytochrome P-450 CYP2C19, Heart Valve Prosthesis, Female, VKORC1, business, Pharmacogenetics, Algorithms, medicine.drug
Abstract: Warfarin is the most common oral anticoagulant. Because of a narrow therapeutic range, interindividual differences in drug responses, and the risk of bleeding, there are many challenges in using warfarin. We need to predict the warfarin maintenance dose. However, ethnic-specific algorithms may be required, and some Chinese algorithms do not perform adequately. Therefore, we aimed to establish a Han Chinese appropriate algorithm. We recruited a study group consisting of 361 Han Chinese patients receiving warfarin treatment who had heart valve replacements. Genotyping of 38 single nucleotide polymorphisms (SNPs) in 13 candidate genes was carried out using the MassARRAY. In the derivation cohort, a multiple linear regression model was constructed to predict the warfarin dosage. We evaluated the accuracy of our algorithm in the validation cohort and compared it with the other 5 algorithms based on Han Chinese and other races. We established a Han Chinese-specific pharmacogenetic-guided warfarin dosing algorithm. Warfarin maintenance dosage (mg/day) = 1.787 - 0.023 x (Age) + 1.151 x (BSA [m(2)]) + 0.917 x (VKORC1 AG) + 4.619 x (VKORC1 GG) + 0.595 x (CYP4F2 TT) + 0.707 x (CYP2C19 CC). It explained 58.3% of the variance in warfarin doses in Han Chinese patients and was superior to the other 5 algorithms. The ability of the 6 algorithms which estimate the required dose correctly was tested. Our model had a mean absolute error of 0.74 mg/day, the other 5 models have mean absolute error of 0.81 mg/day, 1.05 mg/day, 1.24 mg/day, 1.18 mg/day, and 0.85 mg/day, respectively. Our model had a mean percentage error of 26.9%, the other 5 models have the mean percentage error of 27.7%, 27.2%, 52.3%, 45.7%, and 29.3%, respectively. Physicians can not adopt algorithm from other race directly to predict warfarin dose in patients with heart valve replacements, they should establish a new algorithm or adjust another algorithm to fit their patients. The algorithm established in this study has the potential to assist physicians in determining warfarin doses that are close to the appropriate doses.
Published: 2018

39. Monascus-fermented monascin and ankaflavin improve the memory and learning ability in amyloid β-protein intracerebroventricular-infused rat via the suppression of Alzheimer's disease risk factors

Author: Lin Pei-Ying, Ya-Wen Hsu, Tzu-Ming Pan, and Chun-Lin Lee
Subjects: Amyloid β, Medicine (miscellaneous), Peptide, Learning abilities, Pharmacology, chemistry.chemical_compound, Medicine, TX341-641, Ankaflavin, chemistry.chemical_classification, Nutrition and Dietetics, biology, Cholesterol, business.industry, Nutrition. Foods and food supply, Alzheimer's disease, Monascus, biology.organism_classification, Monascin, chemistry, Biochemistry, Disease risk, Fermentation, business, Food Science
Abstract: Amyloid-β peptide (Aβ) deposition in the brain damages neurons and eventually results in Alzheimer's disease (AD), and which can be aggravated by cholesterol and high-fat diets. Monascus purpureus-fermented product was proven to prevent AD development. However, the functional compound and mechanism are still unclear. Monascin (MS) and ankaflavin (AK) produced by M. purpureus exhibit antiinflammatory, antioxidative, and hypolipidaemic effects. In this study, serious AD model rats induced by high fat diet and continuous intracerebroventricular (icv) infusion with Aβ40 for 28 days were used to investigate the alleviating and prophylactic effects of MS and AK on the memory and learning abilities, as well as the AD risk factor levels. The results show that feeding MS and AK to AD-induced rats improved their performance (p
Published: 2015

40. System of multi-regions moving object detection in video surveillance

Author: 林培杰 Lin Pei-jie, 程树英 Cheng Shu-ying, 陈志聪 Chen Zhi-cong, 吴丽君 Wu Li-jun, and 郑柏春 Zheng Bo-chun
Subjects: business.industry, Computer science, Signal Processing, Computer vision, Artificial intelligence, business, Instrumentation, Object detection, Electronic, Optical and Magnetic Materials
Published: 2015

41. 53.1: Development of Oxide-TFT OLED-TV Technologies

Author: Chih-Cheng Chen, Hong-Shen Lin, Chun-Hsin Liu, Yu-Hsin Lin, Chia-Yu Chen, Tsung-Hsiang Shih, Lun Tsai, Hong-Jye Hong, Chih-Lei Chen, Li-Fong Lin, Lee-Hsun Chang, Hung-Che Ting, and Lin Pei-Ling
Subjects: Materials science, business.industry, Thin-film transistor, Electrical engineering, OLED, Optoelectronics, Chemical vapor deposition, Metalorganic vapour phase epitaxy, business, Oxide thin-film transistor, Amorphous solid, Compensation (engineering), Threshold voltage
Abstract: We reported amorphous Indium-Gallium-Zinc-Oxide (a-IGZO) TFT OLED TV panel development in AUO. The Generation 6 (G6) threshold voltage uniformity can be lower than 0.8V. The RGB side-by-side OLED patterning was realized by fine metal mask. By the application of a source follower connection pixel compensation circuit, the panels driven by AUO engine show excellent characteristics. For future product performance requirement, amorphous Indium-Tin-Zinc-Oxide (a-ITZO) TFT was developing, high mobility as 33.2 cm2/Vs was achieved. Metal-organic chemical vapor deposition (MOCVD) system was also used to improve the mobility of IGZO TFT. To improve manufacturing efficiency of OLED process, inkjet printing technology is also under development in AUO.
Published: 2014

42. Rapid Defect Reconstruction Based on Genetic Algorithm and Similar Model in Remote Field Eddy Current Non-Destructive Testing

Author: Xiao Jie Xu and Wen Lin Pei
Subjects: Engineering, Field (physics), business.industry, Computation, Defect reconstruction, General Medicine, Inverse problem, law.invention, law, Nondestructive testing, Genetic algorithm, Convergence (routing), Eddy current, business, Algorithm
Abstract: Defect reconstruction of remote field eddy current belonged to electromagnetic inverse problem in materia Non-Destructive Testing. In view of disadvantages in present defect reconstruction methods, such as over-long time or excessive need for training samples, a new defect reconstruction method based on similar model and genetic algorithm was investigated as follows: similar model between non-axisymetric defect and axisymetric defect was represented, and proportionality factor was deduced by skin depth equation. As a result, the time-consuming forward problem solution in defect reconstruction, which using 3D finite element computation conventionally, was simplified to 2D finite element computation. At the same time, a method designed to accelerate convergence of genetic algorithm was adopted, and more times saving were obtained. Computation results show that, total defect reconstruction time is reduced to 7.6%, compared with directly 3D finite elemet computation, while reconstruction accuracy remains almost the same.
Published: 2014

43. Prognostic significance of cytogenetic abnormalities in T-cell prolymphocytic leukemia

Author: Sa A. Wang, Yi Sun, Andrés E. Quesada, Zhenya Tang, L. Jeffrey Medeiros, Zhihong Hu, Guilin Tang, Xinyan Lu, Lin Pei, Lianghua Fang, Tsieh Sun, and Shimin Hu
Subjects: Adult, Male, medicine.medical_specialty, Gastroenterology, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, Proto-Oncogene Proteins, Complex Karyotype, medicine, Humans, Prolymphocytic leukemia, Survival analysis, In Situ Hybridization, Fluorescence, Aged, Aged, 80 and over, Chromosome Aberrations, medicine.diagnostic_test, business.industry, Karyotype, Hematology, Middle Aged, medicine.disease, Prognosis, Survival Analysis, Transplantation, Leukemia, Treatment Outcome, 030220 oncology & carcinogenesis, Karyotyping, Leukemia, Prolymphocytic, T-Cell, T-cell prolymphocytic leukemia, Female, business, 030215 immunology, Fluorescence in situ hybridization, Stem Cell Transplantation
Abstract: T-cell prolymphocytic leukemia (T-PLL) is an aggressive mature T-cell neoplasm. The most common cytogenetic abnormality associated with T-PLL is inv(14)(q11.2q32) involving TCL1, but other abnormalities also have been reported. In this study, we correlated cytogenetic abnormalities with clinical outcome in 97 T-PLL patients, including 66 men and 31 women with a median age of 63 years (range, 34-81). Twenty-seven patients had a normal karyotype (NK), one had two chromosomal aberrations, and 69 had a complex karyotype (CK). Patients with a CK had poorer overall survival (OS) than patients with a NK (P = .0016). In the CK group, the most common aberrations involved 14q (n = 45) and 8q (n = 38). Additional deletions of chromosomes 17p, 11q, 6q, 12p, 13q were observed frequently. No individual cytogenetic abnormality impacted OS. Patients with ≥5 aberrations had an OS of 11 months versus 22 months in patients with
Published: 2016

44. Origin and evolution characteristics of geothermal water in the Niutuozhen geothermal field, North China Plain

Author: Lin Pei, Zhonghe Pang, Wang Shufang, Ming Yin, Sida Liu, and Liu Jiurong
Subjects: Hydrology, geography, geography.geographical_feature_category, δ18O, business.industry, Geothermal energy, Dolomite, Geochemistry, Aquifer, Groundwater recharge, Rainwater harvesting, General Earth and Planetary Sciences, business, Geothermal gradient, Groundwater, Geology
Abstract: Statistical study of analyses of water from 43 samples from geothermal wells, three groundwater wells, and one sample of local rainwater along with rainwater data from the Global Network of Isotopes in Precipitation has been used to identify the origin and evolution of geothermal water in the Niutuozhen (牛驼镇) geothermal field and estimate the renewability rate of its geothermal resource. The results show that the geothermal waters of the Jixianian Wumishanian dolomite reservoir and the Ordovician limestone reservoir are of Cl-Na type, the geothermal water of the Pliocene Minghuazhen (明化镇) Formation sandstone reservoir are Cl-Na type and HCO3-Na type and the groundwater of the Quaternary aquifer is HCO3-Na and HCO3-Na·Mg·Ca type. A linear relationship between silica concentration and temperature indicates that higher temperature probably enhances concentration of silica in Jixianian geothermal water. δ18O shift in Wumishanian geothermal water averaged 1.57‰, and was less than 1‰ in the other geothermal waters. The minimum and maximum 14C ages of Wumishanian geothermal water are 17 000 and 33 000 years from north to the south of the Niutuozhen geothermal field. Geothermal water and Quaternary groundwater belong to different groundwater systems with no hydraulic connections. Although the geothermal field receives some recharge from the Yanshan and Taihang mountains outside the northern and western boundaries of the geothermal field respectively, the renewability rate of geothermal water is on the scale of 10 000 years.
Published: 2013

45. Studies of high-efficiency electrical steels used in electric vehicle motors

Author: Lu-bin Zeng, Xiao Chen, Rui-lin Pei, and Xian-dong Liu
Subjects: Electric motor, Multidisciplinary, Materials science, business.product_category, Permanent magnet synchronous motor, business.industry, Electrical engineering, Mechanical engineering, engineering.material, Mechanical strength, Electric vehicle, engineering, business, Electrical steel
Abstract: Application of permanent magnet synchronous motor (PMSM) has been increasingly popular in electric vehicle (EV) area since cost-effective electrical steels were recently discovered. This paper mainly presents the performance and characteristics of EV motors using varieties of high-efficiency electrical steels. At first, the electro-magnetic and mechanical properties of electrical steels are described. Low loss, high induction and excellent mechanical strength are critical criteria to evaluate the electrical steel. However, the gage of electrical steel is a crucial factor to affect the properties. Secondly, the basic principle and algorithm for calculation of efficiency of an EV motor are explained. Finally, the modeling and experimental results for different gages of electrical steel sheets used in EV motors are analyzed.
Published: 2012

46. Constitutive activation of p38 MAPK in tumor cells contributes to osteolytic bone lesions in multiple myeloma

Author: Yang, Jing, He, Jin, Wang, Ji, Cao, Yabing, Ling, Jianhua, Qian, Jianfei, Lu, Yong, Li, Haiyan, Zheng, Yuhuan, Lan, Yongsheng, Hong, Sungyoul, Matthews, Jairo, Starbuck, Michael W, Navone, Nora M, Orlowski, Robert Z., Lin, Pei, Kwak, Larry W., and Yi, Qing
Subjects: Cancer Research, Pathology, medicine.medical_specialty, Osteoclastogenesis, p38 mitogen-activated protein kinases, Blotting, Western, Myeloma, Apoptosis, Tumor cells, Cell Communication, Mice, SCID, Osteolysis, p38 MAPK, p38 Mitogen-Activated Protein Kinases, Article, Immunoenzyme Techniques, Mice, 03 medical and health sciences, 0302 clinical medicine, Text mining, immune system diseases, hemic and lymphatic diseases, Tumor Cells, Cultured, Animals, Humans, Medicine, RNA, Small Interfering, Multiple myeloma, Cell Proliferation, 030304 developmental biology, 0303 health sciences, business.industry, Hematology, medicine.disease, 3. Good health, Oncology, Bone lesion, Case-Control Studies, 030220 oncology & carcinogenesis, Osteolytic bone lesions, Bone Diseases, Multiple Myeloma, business, Osteoblastogenesis, Signal Transduction
Abstract: Bone destruction is a hallmark of multiple myeloma and affects more than 80% of patients. However, current therapy is unable to completely cure and/or prevent bone lesions. Although it is accepted that myeloma cells mediate bone destruction by inhibition of osteoblasts and activation of osteoclasts, the underlying mechanism is still poorly understood. This study demonstrates that constitutive activation of p38 mitogen-activated protein kinase in myeloma cells is responsible for myeloma-induced osteolysis. Our results show that p38 is constitutively activated in most myeloma cell lines and primary myeloma cells from patients. Myeloma cells with high/detectable p38 activity, but not those with low/undetectable p38 activity, injected into severe combined immunodeficient (SCID) or SCID-hu mice caused bone destruction. Inhibition or knockdown of p38 in human myeloma reduced or prevented myeloma-induced osteolytic bone lesions without affecting tumor growth, survival, or homing to bone. Mechanistic studies showed that myeloma cell p38 activity inhibited osteoblastogenesis and bone formation and activated osteoclastogenesis and bone resorption in myeloma-bearing SCID mice. This study elucidates a novel molecular mechanism-activation of p38 signaling in myeloma cells-by which myeloma cells induce osteolytic bone lesions, and indicates that targeting myeloma cell p38 may be a viable approach to treating or preventing myeloma bone disease.
Published: 2012

47. The α7nACh–NMDA receptor complex is involved in cue-induced reinstatement of nicotine seeking

Author: Fang Liu, Anh D. Lê, Shupeng Li, ZhaoXia Li, and Lin Pei
Subjects: Microinjections, alpha7 Nicotinic Acetylcholine Receptor, media_common.quotation_subject, medicine.medical_treatment, Recombinant Fusion Proteins, Immunology, Blotting, Western, Pharmacology, Receptors, Nicotinic, Polymerase Chain Reaction, Receptors, N-Methyl-D-Aspartate, Nicotine, 03 medical and health sciences, 0302 clinical medicine, Pregnancy, mental disorders, Secondary Prevention, Immunology and Allergy, Medicine, Animals, Immunoprecipitation, Rats, Wistar, Extracellular Signal-Regulated MAP Kinases, 030304 developmental biology, media_common, Acetylcholine receptor, 0303 health sciences, Analysis of Variance, business.industry, Addiction, musculoskeletal, neural, and ocular physiology, Psychoactive drug, Brief Definitive Report, Tobacco Use Disorder, Abstinence, 3. Good health, Rats, Enzyme Activation, Nicotinic agonist, nervous system, Multiprotein Complexes, Smoking cessation, NMDA receptor, Female, biological phenomena, cell phenomena, and immunity, business, 030217 neurology & neurosurgery, psychological phenomena and processes, medicine.drug
Abstract: Disrupting the α7nAChR–NMDAR complex blocks cue-induced nicotine seeking., Smoking is the leading preventable cause of disease, disability, and premature death. Nicotine, the main psychoactive drug in tobacco, is one of the most heavily used addictive substances, and its continued use is driven through activation of nicotinic acetylcholine receptors (nAChRs). Despite harmful consequences, it is difficult to quit smoking because of its positive effects on mood and cognition that are strong reinforcers contributing to addiction. Furthermore, a formidable challenge for the treatment of nicotine addiction is the high vulnerability to relapse after abstinence. There is no currently available smoking cessation product able to achieve a >20% smoking cessation rate after 52 wk, and there are no medications that directly target the relapse process. We report here that the α7nAChR forms a protein complex with the NMDA glutamate receptor (NMDAR) through a direct protein–protein interaction. Chronic nicotine exposure promotes α7nAChR–NMDAR complex formation. Interestingly, administration of an interfering peptide that disrupts the α7nAChR–NMDAR complex decreased extracellular signal-regulated kinase (ERK) activity and blocked cue-induced reinstatement of nicotine seeking in rat models of relapse, without affecting nicotine self-administration or locomotor activity. Our results may provide a novel therapeutic target for the development of medications for preventing nicotine relapse.
Published: 2012

48. Enhance Robustness of Scale-free Networks

Author: Lin Pei, Yiqun Huang, Yongliang Shi, and Jiayin Chen
Subjects: General Computer Science, Robustness (computer science), Computer science, business.industry, Distributed computing, Scale-free network, business, Computer network
Abstract: In this paper, we investigate the effective strategy which can enhance scale-free networks robustness to both random failures and intentional attacks while keeping the average connectivity k per node constant. The numerical results indicate that the strategy, which protects the highest degree nodes, is not effective. In spite of about 3% highest nodes are protected, scale-free networks’ robustness only enhance about 0.1%. While the strategy that adding more edges to make the minimum degree of scale-free networks increase is more effective.
Published: 2011

49. Spectral calibration of the coded aperture spectra imaging system

Author: Qunbo Lv, Yangyang Liu, Wang Jianwei, Lin lin Pei, and Huang Min
Subjects: Physics, medicine.medical_specialty, Spectrometer, business.industry, Astrophysics::Instrumentation and Methods for Astrophysics, Imaging spectrometer, Hyperspectral imaging, Spectral line, Spectral imaging, Imaging spectroscopy, Optics, medicine, Calibration, Coded aperture, business
Abstract: Coded aperture spectroscopy allows for sources of large field to be efficiently coupled into dispersive spectrometers by replacing the traditional input slit with a patterned mask. Spectral calibration is requisite for spectroscopy to obtain the spectrum information exactly. In this paper, we described the spectral calibration’s principle and methods of coded aperture spectral imaging, and then gave the results of the experiment using a monochromatic extended source, at last we tested the accuracy of spectral calibration. The results indicate that this method can calibrate the coded aperture imaging spectrometer with high accuracy.
Published: 2015

50. Fault Caused by Water Pressure in the Head-Cover Chamber

Author: Ze-yu Pei, Jian-hui Li, Hui Li, Hai-lin Pei, and Xue-yi Qi
Subjects: Petroleum engineering, business.industry, Mechanical Engineering, Water pressure, Condensed Matter Physics, law.invention, Vibration, Thrust bearing, Mechanics of Materials, Hydroelectricity, law, Modeling and Simulation, business, Geology, Hydropower
Abstract: Owing to the high temperature of the thrust bearing pads, the No.1 unit wasn't performed in the upgrading test at Liujiaxia Hydropower Plant. Through the experimental and theoretical analysis, it has been confirmed that the fault unit was caused by the high water pressure in the head-cover chamber. This type of the fault is out-of-the-way. After the suitable measure wags against the fault were taken, the No.1 unit can stably operate. The conclusions and the methodology are of the certain reference value to the fault-diagnosis of the hydroelectric unit.
Published: 2006

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