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We report a rare case of metachronous lymphoma with two distinct cell lineages in a 75-year-old man. The patient complained about having nasal obstruction for 2 years and extranodal natural killer (NK)/T-cell lymphoma of the nasal type was diagnosed from a biopsy. The immunohistochemical staining for CD56 and in situ hybridization for Epstein-Barr virus (EBV)–encoded small RNA (EBER-ISH) were positive and the tumor cells were negative for CD20. After 13 months of concurrent chemoradiotherapy, the patient presented with swelling of the left testis. Positron emission tomography scan detected an abnormal uptake in the testis. A diffuse large B-cell lymphoma, not otherwise specified, was diagnosed from subsequent radical orchiectomy. The immunohistochemical staining revealed to be positive for CD20, BCL2, BCL6, and MYC and negative for CD10 and EBER-ISH.

A 79-year-old woman presented to another hospital with complaints of right leg pain. Computed tomography and magnetic resonance imaging of the spine was performed in the other hospital, which showed an abscess in the right iliacus muscle. She was referred to our hospital because of a mass in the right atrium on echocardiography. Inflammatory markers were elevated, and Staphylococcus aureus were identified in blood cultures. Transthoracic echocardiography revealed a shaggy mass in the right atrium that resembled vegetation. Transesophageal echocardiography showed a large cystic mass with a hyperechoic lesion. After surgery, biopsy results indicated that it was a myxoid mass with cystic changes.

This study aims to understand the social perception of the underdog, those who are defeated and weak in the world of sports, and the following conclusions were drawn to provide the basis of future sports underdog research. First, data collection results utilizing text mining showed that words most used in both frequency and TF-IDF were team, uprising, player, reporter and championship. Second, the results of the consolidated centrality index analysis showed the words uprising, reporter, player, team, game in said order. Third, when four clusters were formed from semantic network analysis, the first cluster was named “Sports Games”, the second “Movie”, third “Cheering” and the fourth “Marketing”.

본 연구는 D광역시 K대학교에 재학 중인 남자 태권도 겨루기 선수 28명을 대상으로 경기실적에 따라 우수 및 비우수 선수로 구분하여 다양한 체력요인과 무산소성 운동능력 및 하지 등속성 근 기능의 차이와 관련성을 분석하였다. 연구결과 우수선수는 비우수선수에 비해 체력요인과 무산소성 운동능력이 통계적으로 유의하게 높게 나타났으며, 하지 등속성 근 기능에서도 우수선수는 비우수선수에 비해 긍정적인 결과를 나타냈다. 체력요인과 무산소성 운동능력의 상관관계 분석결과 우수선수는 사이드스텝과 무산소 운동능력(Peak Power, Average Power, Total Energy)에서 비우수 선수는 배근력과 무산소 운동능력(Peak Power, 체중당 Peak Power, Average Power, Total Energy, Peak drop)에서 유의한 상관관계를 나타냈다. 무산소성 운동능력과 하지 등속성 근 기능의 상관관계 분석결과 우수선수는 좌·우신근과 무산소성 운동능력에서 비우수선수는 좌신근 및 좌굴근과 무산소성 운동능력에서 유의한 상관관계를 나타냈으며, 우수선수의 좌측 슬관절의 굴·신근비와 무산소성 운동능력과는 유의한 역상관 관계를 나타냈다. 이상의 내용을 종합해 볼때 우수선수와 비우수선수 간에는 체력요인과 무산소성 운동능력 및 하지 등속성 근 기능에 차이가 있었으며, 이러한 결과는 선수들의 경기력 향상 트레이닝에 유용한 정보를 제공할 수 있을 것으로 사료된다.

It is inevitable for cancer patients to visit the emergency department (ED) for symptoms of cancer itself and various treatment-related complications. As the prevalence of cancer increases along with cancer survival rates, the number of ED visits of cancer patients may increase. This study aimed to investigate the epidemiologic trends and characteristics of cancer-related ED visits. A cross-sectional study was conducted for all ED visits nationwide between 2015 and 2019. The characteristics of cancer- and non-cancer-related ED visits were compared, and the cancer type and primary reason for ED visits were investigated for cancer-related ED visits. The age- and sex-standardized incidence rate per 100,000 population was calculated. Among 44,983,523 ED visits for 5 years, 1,372,119 (3.1%) were cancer-related. Among cancer-related ED visits, 54.8% led to hospitalization including 5.1% in ICU, and 9.5% died in the hospital. The age- and sex-standardized incidence rates of cancer-related ED visits per 100,000 population increased from 521.8 in 2015 to 642.2 in 2019 (p-for-trends

Yi-Chun Lin,1 Shih-Wei Li,2 Shin-Yen Ku,3 Hui-Ting Hsieh,3 Mei-Hui Lin,3 Shu-Yin Chang,3 Wei-Wei Wu,3 Na-Lee Sun,3 Shu-Hsing Cheng,1,4 Chien-Yu Cheng1,51Department of Internal Medicine, Division of Infectious Diseases, Taoyuan General Hospital, Ministry of Health and Welfare, Taoyuan City, Taiwan; 2Division of Gastroenterology, Department of Internal Medicine, Taoyuan General Hospital, Ministry of Health and Welfare, Taoyuan City, Taiwan; 3Comprehensive HIV Care Center, Taoyuan General Hospital, Ministry of Health and Welfare, Taoyuan City, Taiwan; 4School of Public Health, Taipei Medical University, Taipei, Taiwan; 5School of Public Health, National Yang-Ming University, Taipei, TaiwanBackground and aims: We aimed to evaluate the efficacy and tolerability of grazoprevir/elbasvir in patients with chronic genotype 1 hepatitis Cvirus (HCV) and HIV co-infection who experienced peginterferon alfa plus ribavirin (PegIFN/RBV) (clinicaltrials.gov NCT03098121).Methods: This non-randomized, open-label trial study was conducted in Taoyuan General Hospital. HIV-infected patients were screened for HCV antibody since June 1, 2012, and HCV and HIV co-infected patients were tested for HCV RNA. The subjects who experienced PegIFN/RBV were enrolled in the study, and of whom with chronic genotype 1a or 1b received grazoprevir 100 mg and elbasvir 50 mg in a fixed-dose combination tablet once daily with or without ribavirin for 12 to 16 weeks.Results: Of 2,419 HIV-infected patients, 40 patients with chronic genotype 1 HCV and HIV co-infection who failed PegIFN/RBV treatment were enrolled. Sixteen patients had genotype 1a and 24 patients had genotype 1b, with or without cirrhosis. The median age was 42 (41–47) years, and 5 patients (12.5%) were diagnosed with liver cirrhosis (child Pugh score A). The median CD4 count was 504 cells/μL (321–689). All patients (100%) had HIV viral load 10 IU/mL (3.98–7.12). At the end of treatment, all patients (100%, 40/40) had undetectable HCV viral load, and 95.0% (38/40) of patients achieved sustained virologic response at 12 weeks.Conclusion: Grazoprevir/elbasvir was effective in genotype 1 patients co-infected with HIV with or without cirrhosis. This finding is consistent with that of previous trials of this regimen in monoinfected population.Keywords: hepatitis C, grazoprevir and elbasvir, PEGylated interferon plus ribavirin, direct-acting antiviral, HCV genotype 1, HCV/HIV co-infection

This manuscript is a review of the preclinical and early clinical findings related to a unique fluorinated polyphosphazene nanolayer device surface modification. Polyzene-F (PzF) is a novel, high-molecular weight, highly pure polyphosphazene that was designed to enhance the biologic interface between a medical device surface and human tissue or blood. The polymer also has unique mechanical properties that for the first time allow implants to be paved with a coating that has a nanoscale thickness of

Src family kinases (SFKs), an important group of non-receptor tyrosine kinases, are suggested to be excessively activated during various types of tissue fibrosis. The present study investigated the effect of KF-1607, an orally active and a newly synthesized Src kinase inhibitor (SKI) with proposed low toxicity, in preventing the progression of renal interstitial fibrosis. Unilateral ureteral obstruction (UUO) surgery was performed in 6-week-old male C57BL/6 mice to induce renal interstitial fibrosis. Either KF-1607 (30 mg/kg, oral gavage) or PP2 (2 mg/kg, intraperitoneal injection), a common experimental SKI, was administered to mice for seven days, started one day prior to surgery. UUO injury-induced SFK expression, including Src, Fyn, and Lyn kinase. SFK inhibition by KF-1607 prevented the progression of tubular injury in UUO mice, as indicated by decreases in albuminuria, urinary KIM-1 excretion, and kidney NGAL protein expression. Renal tubulointerstitial fibrosis was attenuated in response to KF-1607, as shown by decreases in α-SMA, collagen I and IV protein expression, along with reduced Masson’s trichrome and collagen-I staining in kidneys. KF-1607 also inhibited inflammation in the UUO kidney, as exhibited by reductions in F4/80 positive-staining and protein expression of p-NFκB and ICAM. Importantly, the observed effects of KF-1607 were similar to those of PP2. A new pan Src kinase inhibitor, KF-1607, is a potential pharmaceutical agent to prevent the progression of renal interstitial fibrosis.

The purpose of this study is to analyze the effects of exercise types on cognitive function and on related factors of the female elderly. The selected subjects were divided into walking exercise group, yoga exercise group, aquarobic exercise group and control group(10, 9, 10, 9 respectively). Exercise programs were done for 50~60 minutes a day, three times a week, for 12 weeks. In conclusion, MMSE-K socre and follow command among cognitive functions did not changed in all exercise groups, but decreased in control group. Memory recall and Reaction Time and Recognition increased in yoga and aquarobic exercise respectively. BDNF expression among neurotrophic factors increased in yoga exercise and decreased in control group. And BDNF did not changed in walking and aquarobic exercise. Therefore, it is thought that various types of exercise should be done complexly to improve cognitive functions and BDNF expression.

Ankle disorders are a relatively common pathological condition, and ankle injuries account for approximately 14% of sports-related orthopedic emergency visits. Various imaging modalities can be used to make a diagnosis in cases of ankle pain; however, ultrasound (US) has several benefits for the evaluation of ankle pain, especially in the tendons, ligaments, and nerves of the ankle. The purpose of this article is to review the common causes of ankle pathology, with particular reference to US features. In addition, the importance of a dynamic evaluation and a stress test with US is emphasized.

As smartphone become popular, various information is stored to smartphone inside, so people become to live a convenient life. Even though this advantage, there are many crimes using or by the smartphone, hence, the information stored in the smartphone is able to adapt as an evidence. Therefore, we a...

Summary Purpose We report the clinical outcome after coverage for soft-tissue defect on the medial foot and ankle with an adipofascial fold-down flap based on the posterior tibial artery perforator branch proximal to the defect. Materials Nine patients (five males and four females) with soft-tissue defects on the medial foot and ankle area underwent the procedure from March 2009 to May 2014. The average age of the patients was 54 years (range, 8–82). The pivot point of transposition of this flap is the posterior tibial artery perforator proximal to the defect. Therefore, the adiposal side of this flap was folded down to resurface the defect. The donor site was closed primarily with the preserved skin flap. The skin graft to the flap was delayed until the flap became mature. The difference between the circumferences of both ankles was measured. Results All flaps survived and adequate soft-tissue coverage was obtained for the medial foot and ankle after the skin graft. Wearing normal footwear was possible for all patients because of thin coverage of the flaps. No secondary debulking procedure was performed for the patients. The difference between the circumferences of both sides of the ankle was not significant. The skin necrosis of the donor site was also managed conservatively and healed well. Conclusion For the medial foot and ankle soft-tissue defect, the fold-down adipofascial flaps based on the posterior tibial artery perforator branch proximal to the defect could be a good option to cover it.