7,197 results on '"Leblanc A"'
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2. THE ENERGETIC INFORMATION SUPERHIGHWAY, PART 1: Reiki and Knowledge Production
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Leblanc, Kelly
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Business ,Library and information science - Abstract
Knowledge production and dissemination on a cognitive and subconscious level through the practice of energy transfer using Usui Reiki Ryoho ('Reiki') and sound healing through binaural beats has the potential [...]
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- 2023
3. Art Under Fire: HOW AI CHALLENGES ARTISTIC AUTHENTICITY AND INTEGRITY
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Leblanc, Kelly
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Modernism (Art) ,Creative ability ,Art, Modern ,Business ,Library and information science - Abstract
Using generative AI to produce 'art' is impressive from a technical standpoint, amusing as a novelty, and maybe even useful for some organizational goals, but at what cost? We must [...]
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- 2024
4. Equity, Diversity and Inclusion in Sport Organizations
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Keyser-Verreault, Amélie, Brière, Sophie, St-Pierre, Marilou, Demers, Guylaine, Culver, Diane, LeBlanc, Catriona, Translated by, Keyser-Verreault, Amélie, Brière, Sophie, St-Pierre, Marilou, Demers, Guylaine, Culver, Diane, and LeBlanc, Catriona
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- 2024
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5. Clearing the Cloud Questions: Advances with DOE-ARM Solar Spectral Observation Capabilities
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Riihimaki, Laura D., Flynn, Connor, McComiskey, Allison, Lubin, Dan, Blanchard, yann, Chiu, J. Christine, Feingold, Graham, Feldman, Daniel R., Gristey, Jake J., Herrera, Christian, Hodges, Gary, Kassianov, Evgueni, LeBlanc, Samuel E., Marshak, Alexander, Michalsky, Joseph J., Pilewskie, Peter, Schmidt, Sebastian, Scott, Ryan C., Shea, Yolanda, Thome, Kurtis, Wagener, Richard, and Wielicki, Bruce
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United States. Department of Energy -- Services ,Atmospheric carbon dioxide -- Environmental aspects ,Climate models -- Usage ,Radiation -- Measurement ,Business ,Earth sciences - Abstract
In the decade before the U.S. Department of Energy (DOE) Atmospheric Radiation Measurement (ARM) facility was established in 1992, early modern climate models exhibited large differences in the climate response [...]
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- 2022
6. Exploring the European Union's Digital Markets Act
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Leblanc, Kelly
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Restraint of trade ,Unfair competition (Commerce) ,Business ,Library and information science ,European Union ,European Union. European Commission ,Facebook (Online social network) - Abstract
The Digital Markets Act (DMA) is a European Union (EU) regulation that imposes new rules on the digital economy and Big Tech platforms to increase market fairness, competition, and accountability. [...]
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- 2024
7. THE DICHOTOMY OF ADVERTISING AGENCY SELECTION AND MEDIA DECISIONS: APPLICATIONS IN INTERNATIONAL MARKETS
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Kanso, Ali M. and LeBlanc, H. Paul
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S&P Global Inc. -- International marketing -- International economic relations -- Advertising -- Management ,Advertising campaigns -- International marketing ,Advertising agencies -- International marketing -- International economic relations ,Publishing industry -- International marketing -- International economic relations ,Company business management ,Publishing industry ,Business, general ,Business ,Business, international - Abstract
This research examines two neglected areas in international advertising campaigns: (1) the impact of managers' cultural orientations on agency selection and (2) the relationships between managers' perceptions of factors of media selection and agency selection. Data were generated from a mail survey to American advertising executives whose firms sell consumer durable goods in overseas markets. The findings reveal: (1) culturally-oriented managers, more than non-culturally oriented managers, use foreign advertising agencies and (2) managers' perceptions of general and specific factors of media selection do not influence their selection of advertising agencies. Keywords: advertising agency selection, international markets, cultural factors, INTRODUCTION The world has become a global market. Many companies now sell their products, services, and ideas to as many customers as possible. They depend heavily on foreign markets and [...]
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- 2020
8. WHAT TO EXPECT FROM THE NEWLY ENFORCED CALIFORNIA PRIVACY RIGHTS ACT
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Leblanc, Kelly
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Privacy, Right of -- Laws, regulations and rules ,Consumer protection -- Laws, regulations and rules ,Data security -- Laws, regulations and rules ,Government regulation ,Data security issue ,Business ,Library and information science ,California. Privacy Rights and Enforcement Act of 2020 - Abstract
The California Privacy Rights Act (CPRA), or Proposition 24, was a ballot measure approved by California voters on Nov. 3, 2020, to strengthen California consumers' privacy. If the CPRA sounds [...]
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- 2023
9. THE MAGIC OF DARK PATTERNS: CAN WE EVADE THEIR TRICKERY?
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Leblanc, Kelly
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Web sites -- Design and construction ,User interface -- Forecasts and trends -- Social aspects ,Market trend/market analysis ,User interface ,Business ,Library and information science - Abstract
The psychology of human-centered design meets the shadow side of human-centered design, and when this occurs, dark patterns begin to emerge. Dark patterns, coined in 2010 by Harry Brignull, have [...]
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- 2022
10. Embroidery on Bulky Items: This step-by-step guide shows how to take the difficulty out of personalizing a quilted bag
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Leblanc, Talia
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Business ,Fashion, accessories and textiles industries ,Sports, sporting goods and toys industry - Abstract
Embroidery is a creative, fun and expressive way to personalize bulky items, including bags and luggage, to create a one-of-a-kind, timeless piece. Make a statement and show off your favorite [...]
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- 2021
11. Association Between FIASMAs and Reduced Risk of Intubation or Death in Individuals Hospitalized for Severe COVID‐19: An Observational Multicenter Study
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Hoertel, Nicolas, Sánchez-Rico, Marina, Gulbins, Erich, Kornhuber, Johannes, Carpinteiro, Alexander, Lenze, Eric J., Reiersen, Angela M., Abellán, Miriam, de la Muela, Pedro, Vernet, Raphaël, Blanco, Carlos, Cougoule, Céline, Neuraz, Antoine, Gorwood, Philip, Alvarado, Jesús M., Meneton, Pierre, Limosin, Frédéric, Ancel, Pierre-Yves, Bauchet, Alain, Beeker, Nathanaël, Benoit, Vincent, Bernaux, Mélodie, Bellamine, Ali, Bey, Romain, Bourmaud, Aurélie, Breant, Stéphane, Burgun, Anita, Carrat, Fabrice, Caucheteux, Charlotte, Champ, Julien, Cormont, Sylvie, Daniel, Christel, Dubiel, Julien, Ducloas, Catherine, Esteve, Loic, Frank, Marie, Garcelon, Nicolas, Gramfort, Alexandre, Griffon, Nicolas, Grisel, Olivier, Guilbaud, Martin, Hassen-Khodja, Claire, Hemery, François, Hilka, Martin, Sophie Jannot, Anne, Lambert, Jerome, Layese, Richard, Leblanc, Judith, Lebouter, Léo, Lemaitre, Guillaume, Leprovost, Damien, Lerner, Ivan, Levi Sallah, Kankoe, Maire, Aurélien, Mamzer, Marie-France, Martel, Patricia, Mensch, Arthur, Moreau, Thomas, Orlova, Nina, Paris, Nicolas, Rance, Bastien, Ravera, Hélène, Rozes, Antoine, Salamanca, Elisa, Sandrin, Arnaud, Serre, Patricia, Tannier, Xavier, Treluyer, Jean-Marc, van Gysel, Damien, Varoquaux, Gaël, Vie, Jill Jen, Wack, Maxime, Wajsburt, Perceval, Wassermann, Demian, Zapletal, Eric, Institut de psychiatrie et neurosciences de Paris (IPNP - U1266 Inserm), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité), Hôpital Corentin Celton [Issy-les-Moulineaux], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO), Universidad Complutense de Madrid = Complutense University of Madrid [Madrid] (UCM), University of Duisburg-Essen, Friedrich-Alexander Universität Erlangen-Nürnberg (FAU), Washington University School of Medicine in St. Louis, Washington University in Saint Louis (WUSTL), Hôpital Européen Georges Pompidou [APHP] (HEGP), National Institute on Drug Abuse [Bethesda] (NIDA), Institut de pharmacologie et de biologie structurale (IPBS), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS), Hôpital Cochin [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Centre de Recherche des Cordeliers (CRC (UMR_S_1138 / U1138)), École pratique des hautes études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Université Paris Cité (UPCité), CHU Necker - Enfants Malades [AP-HP], Laboratoire d'Informatique Médicale et Ingénierie des Connaissances en e-Santé (LIMICS), Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Université Sorbonne Paris Nord, AP-HP / Université de Paris / INSERM COVID-19 research collaboration, AP-HP COVID CDR Initiative, 'Entrepôt de Données de Santé' AP-HP Consortium: Pierre-Yves Ancel, Alain Bauchet, Nathanaël Beeker, Vincent Benoit, Mélodie Bernaux, Ali Bellamine, Romain Bey, Aurélie Bourmaud, Stéphane Breant, Anita Burgun, Fabrice Carrat, Charlotte Caucheteux, Julien Champ, Sylvie Cormont, Christel Daniel, Julien Dubiel, Catherine Ducloas, Loic Esteve, Marie Frank, Nicolas Garcelon, Alexandre Gramfort, Nicolas Griffon, Olivier Grisel, Martin Guilbaud, Claire Hassen-Khodja, François Hemery, Martin Hilka, Anne Sophie Jannot, Jerome Lambert, Richard Layese, Judith Leblanc, Léo Lebouter, Guillaume Lemaitre, Damien Leprovost, Ivan Lerner, Kankoe Levi Sallah, Aurélien Maire, Marie-France Mamzer, Patricia Martel, Arthur Mensch, Thomas Moreau, Antoine Neuraz, Nina Orlova, Nicolas Paris, Bastien Rance, Hélène Ravera, Antoine Rozes, Elisa Salamanca, Arnaud Sandrin, Patricia Serre, Xavier Tannier, Jean-Marc Treluyer, Damien van Gysel, Gaël Varoquaux, Jill Jen Vie, Maxime Wack, Perceval Wajsburt, Demian Wassermann, Eric Zapletal, Martinez Rico, Clara, Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Paris (UP), National Institute on Drug Abuse [Bethesda], Centre National de la Recherche Scientifique (CNRS)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Université de Paris (UP), Collaborators : AP-HP / Université de Paris / INSERM COVID-19 research collaboration, AP-HP COVID CDR Initiative, 'Entrepôt de Données de Santé' AP-HP Consortium: Pierre-Yves Ancel, Alain Bauchet, Nathanaël Beeker, Vincent Benoit, Mélodie Bernaux, Ali Bellamine, Romain Bey, Aurélie Bourmaud, Stéphane Breant, Anita Burgun, Fabrice Carrat, Charlotte Caucheteux, Julien Champ, Sylvie Cormont, Christel Daniel, Julien Dubiel, Catherine Ducloas, Loic Esteve, Marie Frank, Nicolas Garcelon, Alexandre Gramfort, Nicolas Griffon, Olivier Grisel, Martin Guilbaud, Claire Hassen-Khodja, François Hemery, Martin Hilka, Anne Sophie Jannot, Jerome Lambert, Richard Layese, Judith Leblanc, Léo Lebouter, Guillaume Lemaitre, Damien Leprovost, Ivan Lerner, Kankoe Levi Sallah, Aurélien Maire, Marie-France Mamzer, Patricia Martel, Arthur Mensch, Thomas Moreau, Antoine Neuraz, Nina Orlova, Nicolas Paris, Bastien Rance, Hélène Ravera, Antoine Rozes, Elisa Salamanca, Arnaud Sandrin, Patricia Serre, Xavier Tannier, Jean-Marc Treluyer, Damien Van Gysel, Gaël Varoquaux, Jill Jen Vie, Maxime Wack, Perceval Wajsburt, Demian Wassermann, Eric Zapletal, Universität Duisburg-Essen = University of Duisburg-Essen [Essen], Université de Toulouse (UT)-Université de Toulouse (UT)-Centre National de la Recherche Scientifique (CNRS), École Pratique des Hautes Études (EPHE), Health data- and model- driven Knowledge Acquisition (HeKA), Inria de Paris, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria)-Centre de Recherche des Cordeliers (CRC (UMR_S_1138 / U1138)), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Université Paris Cité (UPCité)-École Pratique des Hautes Études (EPHE), Imagine - Institut des maladies génétiques (IMAGINE - U1163), and Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)
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Male ,[SDV]Life Sciences [q-bio] ,medicine.medical_treatment ,Medizin ,law.invention ,Cohort Studies ,COVID-19 Testing ,medications ,Randomized controlled trial ,law ,Clinical endpoint ,Intubation ,Pharmacology (medical) ,Enzyme Inhibitors ,acid sphingomyelinase ,Aged, 80 and over ,[SDV.MHEP] Life Sciences [q-bio]/Human health and pathology ,treatment ,Inverse probability weighting ,Hazard ratio ,Middle Aged ,3. Good health ,Hospitalization ,[SDV] Life Sciences [q-bio] ,Sphingomyelin Phosphodiesterase ,Female ,FIASMA ,Adult ,medicine.medical_specialty ,Adolescent ,intubation ,Young Adult ,Internal medicine ,Intubation, Intratracheal ,medicine ,Humans ,ceramide ,Aged ,Retrospective Studies ,Pharmacology ,SARS-CoV-2 ,Proportional hazards model ,business.industry ,COVID-19 ,mortality ,Confidence interval ,COVID-19 Drug Treatment ,Observational study ,business ,[SDV.MHEP]Life Sciences [q-bio]/Human health and pathology - Abstract
Collaborators : AP-HP / Université de Paris / INSERM COVID-19 research collaboration, AP-HP COVID CDR Initiative, “Entrepôt de Données de Santé” AP-HP Consortium: Pierre-Yves Ancel, Alain Bauchet, Nathanaël Beeker, Vincent Benoit, Mélodie Bernaux, Ali Bellamine, Romain Bey, Aurélie Bourmaud, Stéphane Breant, Anita Burgun, Fabrice Carrat, Charlotte Caucheteux, Julien Champ, Sylvie Cormont, Christel Daniel, Julien Dubiel, Catherine Ducloas, Loic Esteve, Marie Frank, Nicolas Garcelon, Alexandre Gramfort, Nicolas Griffon, Olivier Grisel, Martin Guilbaud, Claire Hassen-Khodja, François Hemery, Martin Hilka, Anne Sophie Jannot, Jerome Lambert, Richard Layese, Judith Leblanc, Léo Lebouter, Guillaume Lemaitre, Damien Leprovost, Ivan Lerner, Kankoe Levi Sallah, Aurélien Maire, Marie-France Mamzer, Patricia Martel, Arthur Mensch, Thomas Moreau, Antoine Neuraz, Nina Orlova, Nicolas Paris, Bastien Rance, Hélène Ravera, Antoine Rozes, Elisa Salamanca, Arnaud Sandrin, Patricia Serre, Xavier Tannier, Jean-Marc Treluyer, Damien Van Gysel, Gaël Varoquaux, Jill Jen Vie, Maxime Wack, Perceval Wajsburt, Demian Wassermann, Eric Zapletal; International audience; Several medications commonly used for a number of medical conditions share a property of functional inhibition of acid sphingomyelinase (ASM), or FIASMA. Preclinical and clinical evidence suggest that the (ASM)/ceramide system may be central to SARS-CoV-2 infection. We examined the potential usefulness of FIASMA use among patients hospitalized for severe COVID-19 in an observational multicenter study conducted at Greater Paris University hospitals. Of 2,846 adult patients hospitalized for severe COVID-19, 277 (9.7%) were taking a FIASMA medication at the time of their hospital admission. The primary endpoint was a composite of intubation and/or death. We compared this endpoint between patients taking vs. not taking a FIASMA medication in time-to-event analyses adjusted for sociodemographic characteristics and medical comorbidities. The primary analysis was a Cox regression model with inverse probability weighting (IPW). Over a mean follow-up of 9.2 days (SD=12.5), the primary endpoint occurred in 104 patients (37.5%) receiving a FIASMA medication, and 1,060 patients (41.4%) who did not. Despite being significantly and substantially associated with older age and greater medical severity, FIASMA medication use was significantly associated with reduced likelihood of intubation or death in both crude (HR=0.71; 95%CI=0.58-0.87; p
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- 2021
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12. A Stabilizer Selection Guide: Use these tips to understand the different types of backings, as well as when and why to use each
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Leblanc, Tali A.
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Textile fabrics ,Business ,Fashion, accessories and textiles industries ,Sports, sporting goods and toys industry - Abstract
Stabilizers, also known as backings, always should be used during machine embroidery. We use embroidery stabilizers to secure the fabric in the hoop while embroidering, and they prevent puckering in [...]
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- 2021
13. Headwear-Stitching Solutions: Follow these basic tips for better embroidery on caps, knits, beanies, visors and more
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Leblanc, Talia
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Business ,Fashion, accessories and textiles industries ,Sports, sporting goods and toys industry - Abstract
Embroidering on headwear typically presents challenges that can scare away some embroiderers, even those who have years of experience. Embroidery is a creative, fun and expressive way to personalize items [...]
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- 2021
14. Neural network-derived model accurately predicts oil recovery in water-drive reservoirs: Artificial neural networks are information processing systems constructed to mimic procedures that resemble those of the human brain. They have the ability to learn procedures from training patterns or data. These systems excel at pattern matching, classification, data clustering and forecasting
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Leblanc, Don
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Artificial neural networks -- Models ,Neurons -- Research ,Statistics (Data) -- Usage ,Petroleum mining ,Brain ,Technology ,Legal fees ,Petroleum industry ,Neural network ,Business ,Petroleum, energy and mining industries - Abstract
The fundamental basis for artificial neural network (ANN) technology is the universal approximation theorem. (1) This theorum states that any continuous function that maps a set of real numbers, to [...]
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- 2019
15. Selinexor‐based regimens in patients with multiple myeloma after prior anti‐B‐cell maturation antigen treatment
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Brea Lipe, Sascha A. Tuchman, Noa Biran, Michael Sebag, Jatin J. Shah, Sumit Madan, Michael Kauffman, Heather J. Sutherland, William I. Bensinger, Nizar J. Bahlis, Jorge Monge, Ohad S. Bentur, Rami Kotb, Cristina Gasparetto, Richard Leblanc, Muhamed Baljevic, Christopher P. Venner, Darrell White, Gary J. Schiller, Andrew DeCastro, Dane Van Domelen, Chris Zhiyi Zhang, Natalie S. Callander, Suzanne Lentzsch, Sharon Shacham, and Christine Chen
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business.industry ,B-Cell Maturation Antigen ,Immunology ,medicine ,Cancer research ,In patient ,Cell Biology ,Hematology ,medicine.disease ,business ,Biochemistry ,Multiple myeloma - Abstract
Background Multiple myeloma (MM) is considered an incurable hematologic malignancy despite a plethora of standard and novel agents. There is no consensus on the optimal sequencing of available therapies in relapsed/refractory MM (RRMM), even in the second line setting. Novel agents such as selinexor (XPOVIO [X]), an oral, first-in-class selective inhibitor of nuclear export (SINE) compound that blocks XPO1, or those that target B-cell maturation antigen (BCMA), have shown significant activity in RRMM. X is approved with bortezomib (V) and dexamethasone (XVd) in patients (pts) with at least 1 prior therapy and is not associated with known long-term clinically significant toxicities such as visual loss, cardiac dysfunction, renal failure, neuropathy, irreversible bone marrow suppression, second malignancies, venous thromboembolism, or rash. Currently, BCMA-targeting agents include 1 form each of chimeric antigen receptor T cell (CAR-T cell) and antibody drug conjugate (ADC) therapy approved in RRMM: idecabtagene vicleucel and belantamab mafodotin, respectively. BCMA-refractory MM represents an area of unmet need in MM without known standards for best treatment. Various novel combinations with X have demonstrated strong benefit in RRMM after 1 or more lines of therapy and activity even in CAR-T cell BCMA-refractory MM (N=7): 1 pt stringent complete (sCR), 3 very good partial (VGPR), 2 partial (PR), and 1 minimal (MR) response (Chari BJH 2020). Here we report on the outcomes of heavily pretreated RRMM pts, a majority of whom had received ADC-BCMA, and who were treated with X-containing regimens on the STOMP trial. Methods STOMP (NCT02343042) is a phase 1b/2, multi-arm, open-label trial of various combinations of X with backbone agents for pts with RRMM or newly diagnosed MM. Here we report on all pts in STOMP with prior anti-BCMA treatment who were treated on STOMP with X+pomalidomide +dexamethasone (XPd); XVd; X+carfilzomib+d (XKd); XPVd; and XPd+elotuzumab (E) (XPEd). Results In total, 11 pts with prior anti-BCMA therapy (6 pts with belantamab mafodotin; 1 each with MEDI2228, SEA-BCMA, BCMA BITE; 2 with idecabtagene vicleucel) were treated with 5 X-containing regimens (Table 1): 9 pts were treated with triplets XPd (4), XVd (3), or XKd (2) and 2 pts with quadruplets XPVd (1) or XPEd (1). Median age was 71 years (range 46-85), 7 pts (63.6%) were women, 11 pts were white. Median duration from MM diagnosis to treatment with a STOMP regimen was 6.9 years (range 2.3-12.8). Five pts (45.5%) had high-risk cytogenetics; pts received median of 6 prior therapies (range 4-10). Eight pts (72.7%) received anti-BCMA in their immediate prior line of therapy. Ten pts (90.9%) were previously treated with all backbone drugs of the STOMP treatments (i.e., X was the only new drug). The overall response rate (ORR) and clinical benefit rate (CBR) for the prior anti-BCMA-containing regimens were 40.0% (2 pts VGPR, 2 PR, 5 stable disease [SD], 1 progressive disease, 1 unknown). Median progression free survival (PFS) was 1.8 months (95% CI: 1.5, NE), and the 6-month PFS probability was 12.5% (95% CI: 2.1, 76.2). ORR for the X-based treatments was 54.5% and CBR was 81.8%: 1 pt VGPR, 5 PR, 3 MR, 2 SD. Median PFS was not reached (95% CI: 5.9, NE) and the 6-month PFS probability was 68.6% (95% CI: 40.3, 100.0). Median overall survival was 10.5 months (95% CI: 9.6, NE) and median time to discontinuation was 8.1 months (95% CI: 6.1, NE). The most common treatment-emergent adverse events were nausea and thrombocytopenia. Nausea was Grade (G) 1/2 (n=8, 72.7%); thrombocytopenia G1-4 in 8 pts (72.7%), 4 with ≥G3; there were no concurrent bleeding events. One pt on XPEd died of pulmonary nocardiosis considered to be associated with the 4-drug regimen. No new safety signals or long-term toxicities due to X were reported. Conclusions In this follow-up cohort of heavily pretreated pts, a majority of whom with MM refractory to ADC-BCMA, we demonstrate impressive potency and durability of the X-based treatments, particularly as compared to that of their prior anti-BCMA therapies. These data support the rationale for the development of novel regimens containing X plus immunomodulatory drugs or proteasome inhibitors in earlier lines of therapy, including first relapse, and further suggest their strong value in the emerging BCMA RRMM space. Figure 1 Figure 1. Disclosures Baljevic: Exelixis: Research Funding; Amgen: Research Funding; Karyopharm: Membership on an entity's Board of Directors or advisory committees; Janssen Research: Membership on an entity's Board of Directors or advisory committees; Oncopeptides: Membership on an entity's Board of Directors or advisory committees; BMS/Celgene: Consultancy, Membership on an entity's Board of Directors or advisory committees. Gasparetto: Karyopharm: Consultancy, Honoraria, Speakers Bureau; Gsk: Consultancy, Honoraria, Speakers Bureau; Janssen: Consultancy; Sanofi: Consultancy, Honoraria, Speakers Bureau; Oncopeptide: Consultancy, Honoraria, Speakers Bureau. Schiller: Sangamo: Research Funding; BMS/Celgene: Consultancy, Current equity holder in publicly-traded company, Research Funding, Speakers Bureau; Celator: Research Funding; Geron: Research Funding; Incyte: Consultancy, Membership on an entity's Board of Directors or advisory committees, Research Funding, Speakers Bureau; PrECOG: Research Funding; Onconova: Research Funding; Pfizer: Current equity holder in publicly-traded company, Research Funding; Genentech-Roche: Research Funding; Karyopharm: Research Funding; Kite/Gilead: Honoraria, Research Funding, Speakers Bureau; Takeda: Research Funding; Abbvie: Research Funding; Forma: Research Funding; Deciphera: Research Funding; Daiichi-Sankyo: Research Funding; Stemline Therapeutics, Inc.: Honoraria, Research Funding, Speakers Bureau; Regimmune: Research Funding; FujiFilm: Research Funding; Gamida Cell Ltd.: Research Funding; Constellation Pharmaceuticals: Research Funding; Mateon: Research Funding; Astellas: Honoraria, Research Funding, Speakers Bureau; Arog: Research Funding; Delta-Fly: Research Funding; Tolero: Research Funding; Samus: Research Funding; Actuate: Research Funding; Actinium Pharmaceuticals, Inc: Research Funding; Trovagene: Research Funding; Agios: Consultancy, Research Funding, Speakers Bureau; Amgen: Consultancy, Current equity holder in publicly-traded company, Honoraria, Research Funding, Speakers Bureau; Jazz: Consultancy, Honoraria, Research Funding, Speakers Bureau; Elevate: Research Funding; Bio: Research Funding; Ono-UK: Consultancy, Research Funding; Novartis: Consultancy, Research Funding; Sanofi: Honoraria, Research Funding, Speakers Bureau; Pharma: Consultancy; Johnson & Johnson: Current equity holder in publicly-traded company; Biomed Valley Discoveries: Research Funding; Eli Lilly: Research Funding; ASH foundation: Other: Chair-unpaid; Sellas: Research Funding; Ono: Consultancy; Incyte: Consultancy; Ariad: Research Funding; AstraZeneca: Consultancy; Kaiser Permanente: Consultancy; Cyclacel: Research Funding; MedImmune: Research Funding; Ambit: Research Funding; Leukemia & Lymphoma Society: Research Funding; Bluebird Bio: Research Funding; Boehringer-Ingleheim: Research Funding; Cellerant: Research Funding; CTI Biopharma: Research Funding; Janssen: Research Funding; Kura Oncology: Research Funding; Pharmacyclics: Honoraria, Speakers Bureau; Millennium: Research Funding; National Marrow Donor Program: Research Funding; NIH: Research Funding; Onyx: Research Funding; Pharmamar: Research Funding; UC Davis: Research Funding; UCSD: Research Funding; Evidera: Consultancy; NCI: Consultancy; Novartis: Speakers Bureau. Tuchman: Caelum: Consultancy, Research Funding; Sanofi / Genzyme: Consultancy, Research Funding; Shattuck Labs: Consultancy; Karyopharm: Research Funding; Oncopeptides: Consultancy. Lentzsch: Sanofi: Consultancy, Research Funding; Celularity: Consultancy; AbbVie: Consultancy; GSK: Consultancy; Takeda: Consultancy; Karyopharm: Consultancy, Research Funding; Janssen: Consultancy; Oncopeptides: Consultancy; Caelum Biosciences: Consultancy, Current holder of individual stocks in a privately-held company; Ossium Health: Consultancy; Magenta Therapeutics: Current equity holder in publicly-traded company; Kadmon: Current equity holder in publicly-traded company. Monge: Karyopharm: Research Funding; BMS: Consultancy. Kotb: Celgene: Honoraria; Karyopharm: Current holder of individual stocks in a privately-held company; Pfizer: Honoraria; Amgen: Honoraria; Janssen: Honoraria; Takeda: Honoraria; BMS: Honoraria; Sanofi: Honoraria, Research Funding; Merck: Honoraria, Research Funding; Akcea: Honoraria. Bahlis: GlaxoSmithKline: Consultancy, Honoraria; Takeda: Consultancy, Honoraria; Pfizer: Consultancy, Honoraria; Sanofi: Consultancy, Honoraria; Janssen: Consultancy, Honoraria; Amgen: Consultancy, Honoraria; Karyopharm: Consultancy, Honoraria; BMS/Celgene: Consultancy, Honoraria; Abbvie: Consultancy, Honoraria; Genentech: Consultancy. White: Forus: Consultancy, Honoraria; Antengene: Consultancy, Honoraria; Janssen: Consultancy, Honoraria; Karyopharm: Consultancy, Honoraria; Amgen: Consultancy, Honoraria; Sanofi: Consultancy, Honoraria; BMS/Celgene: Consultancy, Honoraria; GSK: Consultancy, Honoraria; Takeda: Consultancy, Honoraria. Chen: BMS: Consultancy, Membership on an entity's Board of Directors or advisory committees; Gilead: Consultancy, Membership on an entity's Board of Directors or advisory committees; Novartis: Consultancy, Membership on an entity's Board of Directors or advisory committees; Astrazeneca: Membership on an entity's Board of Directors or advisory committees; Beigene: Membership on an entity's Board of Directors or advisory committees; Janssen: Consultancy. Sutherland: GSK: Research Funding; Celgene: Consultancy; Janssen: Consultancy, Research Funding; Karyopharm: Research Funding; Amgen: Consultancy. Madan: Janssen: Consultancy, Speakers Bureau; BMS: Consultancy, Speakers Bureau; Sanofi: Consultancy, Research Funding; GSK: Consultancy, Speakers Bureau; Amgen: Consultancy, Speakers Bureau; Karyopharm: Research Funding, Speakers Bureau; Takeda: Speakers Bureau. Leblanc: Celgene/BMS: Research Funding; BMS/Celgene Canada: Membership on an entity's Board of Directors or advisory committees; Janssen Canada: Membership on an entity's Board of Directors or advisory committees; Amgen Canada: Membership on an entity's Board of Directors or advisory committees; Sanofi Canada: Membership on an entity's Board of Directors or advisory committees; Takeda Canada: Membership on an entity's Board of Directors or advisory committees. Sebag: Janssen: Research Funding; Amgen: Consultancy, Honoraria; Karyopharm Therapeutics: Consultancy, Honoraria; Sanofi: Consultancy, Honoraria; Takeda: Consultancy, Honoraria; Bristol Myers-Squibb: Consultancy, Honoraria; Novartis: Consultancy, Honoraria. Venner: Janssen: Honoraria; Amgen: Honoraria; Takeda: Honoraria; Celgene: Research Funding; Amgen: Research Funding. Bensinger: BMS, Janssen, Poseida, Regeneron, Trillium: Research Funding; Amgen, BMS, Janssen, Sanofi: Speakers Bureau. DeCastro: Karyopharm: Current Employment, Current equity holder in publicly-traded company. Van Domelen: Karyopharm: Current Employment, Current equity holder in publicly-traded company. Bentur: Karyopharm Therapeutics: Current Employment, Current equity holder in publicly-traded company. Zhang: Karyopharm Therapeutics Inc.: Current Employment, Current equity holder in publicly-traded company. Shah: Karyopharm Therapeutics Inc.: Current Employment, Current equity holder in publicly-traded company. Shacham: Karyopharm: Current Employment, Current equity holder in publicly-traded company, Patents & Royalties: (8999996, 9079865, 9714226, PCT/US12/048319, and I574957) on hydrazide containing nuclear transport modulators and uses, and pending patents PCT/US12/048319, 499/2012, PI20102724, and 2012000928) . Kauffman: Karyopharm Therapeutics Inc.: Current Employment, Current equity holder in publicly-traded company. Lipe: Seagen Inc.: Research Funding; BMS: Consultancy, Research Funding; Janssen: Consultancy, Research Funding; sanofi: Consultancy; GlaxoSmithKline: Consultancy; amgen: Research Funding; Cellectar: Research Funding; Karyopharm: Research Funding; Harpoon: Research Funding.
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- 2022
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16. Persistent fatigue among long-term non-Hodgkin lymphoma survivors
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Thomas W. LeBlanc, Sheryl Zimmerman, Sophia K. Smith, Matthew R. LeBlanc, Ashley Leak Bryant, and Kathryn Elizabeth Hudson
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Persistence (psychology) ,Cancer Research ,Pediatrics ,medicine.medical_specialty ,medicine.medical_treatment ,media_common.quotation_subject ,Population ,Logistic regression ,Article ,Surveys and Questionnaires ,Survivorship curve ,Humans ,Medicine ,Survivors ,education ,Fatigue ,media_common ,education.field_of_study ,Chemotherapy ,business.industry ,Lymphoma, Non-Hodgkin ,Hematology ,medicine.disease ,Lymphoma ,Oncology ,Cohort ,Quality of Life ,Female ,business ,Vigilance (psychology) - Abstract
This study describes the prevalence and persistence of fatigue among a cohort of long-term non-Hodgkin lymphoma (NHL) survivors. Mailed surveys assessed quality-of-life including fatigue (SF-36) at baseline and five years. Logistic regression was used to identify factors associated with prevalence of fatigue at baseline and persistence of fatigue across timepoints. More than one-quarter (27.7%) of the 555 NHL survivors reported clinically meaningful fatigue at baseline and 18.7% reported persistent fatigue at five years. One-third (34.4%) reported clinically meaningful worsening of fatigue over time. Independent associations with persistent fatigue included female gender, less education, past chemotherapy, increased comorbidities, and posttraumatic stress symptoms (P
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- 2021
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17. DARK PATTERNS DEEP DIVE: BAIT AND SWITCH AND DISGUISED ADS
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Leblanc, Kelly
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False advertising -- Methods ,Business ,Library and information science - Abstract
Dark patterns are deceptive web design elements that manipulate the user into making a decision that is contrary to their intended behavior. This behavior may be something the user didn't [...]
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- 2022
18. DARK PATTERNS DEEP DIVE: CONFIRSHAMING
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Leblanc, Kelly
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Business enterprises -- Marketing -- Ethical aspects ,Company marketing practices ,Market trend/market analysis ,Business ,Library and information science - Abstract
Dark patterns are deceptive web design elements that manipulate the user into making a decision that is contrary to their intended behavior. This may be something the user didn't want [...]
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- 2022
19. Make Jacket Embroidery Fun: From specialty thread to the correct needles, jazzing up a design on outerwear doesn't have to be daunting if these tips are followed
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Leblanc, Tali A.
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Clothing ,Business ,Fashion, accessories and textiles industries ,Sports, sporting goods and toys industry - Abstract
(B) Like this article? Read more embroidery articles at impressionsmag.com/embroidery. Fall is right around the corner and will be here before we know it, bringing cooler weather; crisp, vibrant-colored leaves; [...]
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- 2020
20. AGTIONTLAN: Tackling a labor shortage in HVAC
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Gallagher, Mike and Leblanc, Karine
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High schools ,Business ,Petroleum, energy and mining industries - Abstract
Getting the right people on the team has always been essential for any company, in any industry, and HVAC is no exception. Why, then, has the issue become more pressing [...]
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- 2020
21. Factors Associated with Health Care Utilization at the End of Life for Patients with Acute Myeloid Leukemia
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Areej El-Jawahri, Selina M. Luger, Nina O'Connor, Annemarie D. Jagielo, Amir T. Fathi, Thomas W. LeBlanc, Bhavana Bhatnagar, Matthew J. Reynolds, Jason A. Webb, Andrew M. Brunner, Carlisle E.W. Topping, Alison R. Kavanaugh, Dagny M. Vaughn, Gabriela S. Hobbs, and P. Connor Johnson
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medicine.medical_specialty ,Palliative care ,Psychological intervention ,Logistic regression ,Quality of life ,Internal medicine ,Health care ,medicine ,Humans ,General Nursing ,Depression (differential diagnoses) ,Retrospective Studies ,Terminal Care ,business.industry ,General Medicine ,Odds ratio ,Patient Acceptance of Health Care ,United States ,humanities ,Death ,Leukemia, Myeloid, Acute ,Hospice Care ,Anesthesiology and Pain Medicine ,Quality of Life ,Anxiety ,medicine.symptom ,business ,Delivery of Health Care - Abstract
Background: Patients (≥60 years) with acute myeloid leukemia (AML) often receive intense health care utilization at the end of life (EOL). However, factors associated with their health care use at the EOL are unknown. Methods: We conducted a secondary analysis of 168 deceased patients with AML within the United States. We assessed quality of life (QOL) (Functional-Assessment-Cancer-Therapy-Leukemia), and psychological distress (Hospital-Anxiety-and-Depression Scale [HADS]; Patient-Health-Questionnaire-9 [PHQ-9]) at diagnosis. We used multivariable logistic regression models to examine the association between patient-reported factors and the following outcomes: (1) hospitalizations in the last 7 days of life, (2) receipt of chemotherapy in the last 30 days of life, and (3) hospice utilization. Results: About 66.7% (110/165) were hospitalized in the last 7 days of life, 51.8% (71/137) received chemotherapy in the last 30 days of life, and 40.7% (70/168) utilized hospice. In multivariable models, higher education (odds ratio [OR] = 1.54, p = 0.006) and elevated baseline depression symptoms (PHQ-9: OR = 1.09, p = 0.028) were associated with higher odds of hospitalization in the last seven days of life, while higher baseline QOL (OR = 0.98, p = 0.009) was associated with lower odds of hospitalization at the EOL. Higher baseline depression symptoms were associated with receipt of chemotherapy at the EOL (HADS-Depression: OR = 1.10, p = 0.042). Higher education was associated with lower hospice utilization (OR = 0.356, p = 0.024). Conclusions: Patients with AML who are more educated, with higher baseline depression symptoms and lower QOL, were more likely to experience high health care utilization at the EOL. These populations may benefit from interventions to optimize the quality of their EOL care.
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- 2022
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22. Optimization of care for patients with hereditary angioedema living in rural areas
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Douglas T. Johnston, Marc A. Riedl, David M. Lang, John Anderson, D. Soteres, H. James Wedner, Stephen B. LeBlanc, and J. Allen Meadows
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Pulmonary and Respiratory Medicine ,medicine.medical_specialty ,Telemedicine ,business.industry ,Health care provider ,Rural health ,Immunology ,Angioedemas, Hereditary ,Health Status Disparities ,medicine.disease ,United States ,Health equity ,Family medicine ,Hereditary angioedema ,Health care ,Humans ,Immunology and Allergy ,Medicine ,Rural area ,business ,Patient education - Abstract
Objective People living in rural areas of the United States experience greater health inequality than individuals residing in urban or suburban locations and encounter several barriers to obtaining optimal health care. Health disparities are compounded for patients with rare diseases such as hereditary angioedema (HAE), an autosomal dominant genetic disorder characterized by recurrent, severe abdominal pain and lifethreatening oropharyngeal/laryngeal swelling. The objective of this review is to explore the challenges of managing HAE patients in rural areas and suggest possible improvements for optimizing care. Data Sources PubMed was searched for articles on patient care management, treatment challenges, rural health, and HAE. Study Selections Relevant articles were selected and reviewed. Results Challenges in managing HAE in the rural setting were identified including obtaining a diagnosis of HAE, easy access to a physician with expertise in HAE, continuity of care, availability of telemedicine services, access to approved HAE therapies, patient education, and economic barriers to treatment. Ways to improve HAE patient care in rural areas include health care provider recognition of the undiagnosed HAE patient, development of individualized management plans, expansion of telemedicine, effective care at the local level, appropriate access to HAE medication, and increased awareness of patient support and advocacy groups. Conclusion For HAE patients living in rural areas, optimal care is complicated by health disparities. Given the scarcity with which these topics have been covered in the literature to date, it is intended that this article will serve as the impetus for a range of further initiatives focused on improving access to care.
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- 2022
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23. Vehicle Energy Dataset (VED), A Large-Scale Dataset for Vehicle Energy Consumption Research
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David J. LeBlanc, Geunseob Oh, and Huei Peng
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Physics - Physics and Society ,Computer science ,business.industry ,Mechanical Engineering ,Automotive industry ,FOS: Physical sciences ,Physics and Society (physics.soc-ph) ,Energy consumption ,Asset (computer security) ,Computer Science Applications ,Transport engineering ,Auxiliary power unit ,Range (aeronautics) ,Automotive Engineering ,Global Positioning System ,business ,Personally identifiable information ,Energy (signal processing) - Abstract
We present Vehicle Energy Dataset (VED), a novel large-scale dataset of fuel and energy data collected from 383 personal cars in Ann Arbor, Michigan, USA. This open dataset captures GPS trajectories of vehicles along with their time-series data of fuel, energy, speed, and auxiliary power usage. A diverse fleet consisting of 264 gasoline vehicles, 92 HEVs, and 27 PHEV/EVs drove in real-world from Nov, 2017 to Nov, 2018, where the data were collected through onboard OBD-II loggers. Driving scenarios range from highways to traffic-dense downtown area in various driving conditions and seasons. In total, VED accumulates approximately 374,000 miles. We discuss participant privacy protection and develop a method to de-identify personally identifiable information while preserving the quality of the data. After the de-identification, we conducted case studies on the dataset to investigate the impacts of factors known to affect fuel economy and identify energy-saving opportunities that hybrid-electric vehicles and eco-driving techniques can provide. The case studies are supplemented with a number of examples to demonstrate how VED can be utilized for vehicle energy and behavior studies. Potential research opportunities include data-driven vehicle energy consumption modeling, driver behavior modeling, machine and deep learning, calibration of traffic simulators, optimal route choice modeling, prediction of human driver behaviors, and decision making of self-driving cars. We believe that VED can be an instrumental asset to the development of future automotive technologies. The dataset can be accessed at https://github.com/gsoh/VED., 11 pages, 15 figures
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- 2022
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24. Triadic agreement about advanced cancer treatment decisions: Perceptions among patients, families, and oncologists
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Pauline Lyna, Nick Bloom, Kathryn I. Pollak, Thomas W. LeBlanc, James A. Tulsky, Jennie A. Riley, and Karen E. Steinhauser
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Oncologists ,Motivation ,medicine.medical_specialty ,Illness trajectory ,Family caregivers ,business.industry ,media_common.quotation_subject ,Decision Making ,Regret ,General Medicine ,Decisional conflict ,Advanced cancer ,Cancer treatment ,Caregivers ,Neoplasms ,Perception ,Family medicine ,medicine ,Humans ,Treatment decision making ,business ,media_common - Abstract
Objectives When patients make cancer treatment decisions, they consider the needs and preferences of family caregivers and clinicians. We examined how much all three triad members agreed about goals of treatment and caregivers’ influence on decision-making. Methods We surveyed 70 triads of patients, caregivers, and oncologists who had recently made an advanced cancer treatment decision. We assessed each triad member’s perception of the goal of treatment and the caregiver’s influence on the decision. Participants also completed scales related to decisional conflict, satisfaction, and regret. Results In only 28/70 triads (40%), all three agreed on the goal of treatment with the most common goal being to live longer (n = 22). Whereas patients and caregivers tended to think the goal was to cure or live longer, oncologists were less optimistic. In only 22 triads (31%), all three agreed on how much influence the caregiver had on decision-making. Oncologists tended to underestimate caregiver influence. Patients and caregivers had low decisional conflict (M=15.40, SD=4.51; M=17.09, SD=6.34, respectively). Conclusions Advanced cancer treatment decision-making occurs amid incomplete understanding among patients, caregivers, and oncologists. Practice implications Confirming agreement about goals of care and influence on treatment decision-making may increase the likelihood of goal-concordant care throughout the illness trajectory.
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- 2022
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25. Predictors of neurologists confirming or overturning emergency physicians' diagnosis of TIA or stroke
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Ariane Mackey, David J. Gladstone, Judy Morris, Elizabeth Shouldice, Grant Stotts, Albert Y. Jin, Samuel Yip, Clare L. Atzema, Heather Murray, Jeanne Teitelbaum, Achelle Cortel-LeBlanc, Ka Wai Cheung, Nicolas Chagnon, Steve Verreault, Ian G. Stiell, Demetrios J. Sahlas, Wieslaw Oczkowski, Philip Teal, Tarik Slaoui, Mukul Sharma, George A. Wells, Andrew Worster, Kasim Abdulaziz, Mark I. Boulos, Marco L.A. Sivilotti, Jeffrey J. Perry, Marcel Émond, Marie-Christine Camden, Jacques S. Lee, Miguel A Cortel-LeBlanc, and Monica Taljaard
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medicine.medical_specialty ,biology ,business.industry ,Concordance ,Ischemia ,Emergency department ,biology.organism_classification ,medicine.disease ,3. Good health ,03 medical and health sciences ,0302 clinical medicine ,Migraine ,Vertigo ,Internal medicine ,Emergency Medicine ,Etiology ,Medicine ,cardiovascular diseases ,030212 general & internal medicine ,business ,Prospective cohort study ,Stroke ,030217 neurology & neurosurgery - Abstract
Transient ischemic attack (TIA) and non-disabling stroke are common emergency department (ED) presentations. Currently, there are no prospective multicenter studies determining predictors of neurologists confirming a diagnosis of cerebral ischemia in patients discharged with a diagnosis of TIA or stroke. The objectives were to (1) calculate the concordance between emergency physicians and neurologists for the outcome of diagnosing TIA or stroke, and (2) identify characteristics associated with neurologists diagnosing a stroke mimic. This was a planned sub-study of a prospective cohort study at 14 Canadian EDs enrolling patients diagnosed with TIA or non-disabling stroke from 2006 to 2017. Logistic regression was used to identify factors associated with neurologists’ diagnosis of cerebral ischemia. Our primary outcome was the composite outcome of cerebral ischemia (TIA or non-disabling stroke) based on the neurologists’ assessment. The diagnosis of cerebral ischemia was confirmed by neurologists in 5794 patients (55.4%). The most common identified stroke mimics were migraine (18%), peripheral vertigo (7%), syncope (4%), and seizure (3%). Over a third of patients (38.4%) ultimately had an undetermined aetiology for their symptoms. The strongest predictors of cerebral ischemia confirmation were infarct on CT (OR 1.83, 95% CI 1.65–2.02), advanced age (OR comparing 75th–25th percentiles 1.67, 1.55–1.80), language disturbance (OR 1.92, 1.75–2.10), and smoking (OR 1.67, 1.46–1.91). The strongest predictors of stroke mimics were syncope (OR 0.59, 0.48–0.72), vertigo (OR 0.52, 0.45–0.59), bilateral symptoms (OR 0.60, 0.50–0.72), and confusion (OR 0.50, 0.44–0.57). Physicians should have a high index of suspicion of cerebral ischemia in patients with advanced age, smoking history, language disturbance, or infarcts on CT. Physicians should discriminate in which patients to pursue stroke investigations on when deemed at minimal risk of cerebral ischemia, including those with isolated vertigo, syncope, or bilateral symptoms.
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- 2021
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26. HVAC PLAYS CENTRAL ROLE IN ACHIEVING NET ZERO ENERGY BUILDINGS: HVAC technicians are some of the most powerful frontline workers against climate change
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LeBLanc, Laci
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Construction industry ,Global temperature changes ,Emissions (Pollution) ,Business ,Construction and materials industries - Abstract
Between shipping, manufacturing, and construction, climate change is fueled in large part by the building sector In fact, the building industry is responsible for 40% of the world's carbon emissions. [...]
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- 2021
27. Wrestling With the Invincibility Myth: Exploring Physicians’ Resistance to Wellness and Resilience-Building Interventions
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Vicki R. LeBlanc, Kori A LaDonna, Lindsay Cowley, Claire Touchie, and Edward G. Spilg
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Medical education ,business.industry ,media_common.quotation_subject ,Work-Life Balance ,education ,Psychological intervention ,Compassion ,Resistance (psychoanalysis) ,General Medicine ,Burnout, Psychological ,Burnout ,Dehumanization ,Education ,Feeling ,Physicians ,Health care ,Humans ,Medicine ,Psychological resilience ,business ,Psychology ,Burnout, Professional ,media_common - Abstract
Purpose Physicians are expected to provide compassionate, error-free care while navigating systemic challenges and organizational demands. Many are burning out. While organizations are scrambling to address the burnout crisis, physicians often resist interventions aimed at enhancing their wellness and building their resilience. The purpose of this research was to empirically study this phenomenon. Method Constructivist grounded theory was used to inform the iterative data collection and analysis process. In spring 2018, 22 faculty physicians working in Canada participated in semistructured interviews to discuss their experiences of wellness and burnout, their perceptions of wellness initiatives, and how their experiences and perceptions influence their uptake of the rapidly proliferating strategies aimed at nurturing their resilience. Themes were identified using constant comparative analysis. Results Participants suggested that the values of compassion espoused by health care organizations do not extend to physicians, and they described feeling dehumanized by professional values steeped in an invincibility myth in which physicians are expected to be "superhuman" and "sacrifice everything" for medicine. Participants described that professional values and organizational norms impeded work-life balance, hindered personal and professional fulfillment, and discouraged disclosure of struggles. In turn, participants seemed to resist wellness and resilience-building interventions focused on fixing individuals rather than broader systemic, organizational, and professional issues. Participants perceived that efforts aimed at building individual resilience are futile without changes in professional values and sustained organizational support. Conclusions Findings suggest that professional and organizational norms and expectations trigger feelings of dehumanization for some physicians. These feelings likely exacerbate burnout and may partly explain physicians' resistance to resilience-building strategies. Mitigating burnout and developing and sustaining a resilient physician workforce will require both individual resistance to problematic professional values and an institutional commitment to creating a culture of compassion for patients and physicians alike.
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- 2022
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28. Printing thermoelectric inks toward next-generation energy and thermal devices
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Yanliang Zhang, Minxiang Zeng, Saniya LeBlanc, Mortaza Saeidi-Javash, G. Jeffrey Snyder, Jiahao Chen, Duncan Zavanelli, and Yipu Du
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Inkwell ,business.industry ,Thermoelectric effect ,Figure of merit ,General Chemistry ,Electronics ,Conformable matrix ,business ,Thermoelectric materials ,Energy harvesting ,Engineering physics ,Thermal energy - Abstract
The ability of thermoelectric (TE) materials to convert thermal energy to electricity and vice versa highlights them as a promising candidate for sustainable energy applications. Despite considerable increases in the figure of merit zT of thermoelectric materials in the past two decades, there is still a prominent need to develop scalable synthesis and flexible manufacturing processes to convert high-efficiency materials into high-performance devices. Scalable printing techniques provide a versatile solution to not only fabricate both inorganic and organic TE materials with fine control over the compositions and microstructures, but also manufacture thermoelectric devices with optimized geometric and structural designs that lead to improved efficiency and system-level performances. In this review, we aim to provide a comprehensive framework of printing thermoelectric materials and devices by including recent breakthroughs and relevant discussions on TE materials chemistry, ink formulation, flexible or conformable device design, and processing strategies, with an emphasis on additive manufacturing techniques. In addition, we review recent innovations in the flexible, conformal, and stretchable device architectures and highlight state-of-the-art applications of these TE devices in energy harvesting and thermal management. Perspectives of emerging research opportunities and future directions are also discussed. While this review centers on thermoelectrics, the fundamental ink chemistry and printing processes possess the potential for applications to a broad range of energy, thermal and electronic devices.
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- 2022
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29. Diagnosing atopic dermatitis in infancy using established diagnostic criteria: a cohort study
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Knut Rudi, Petter Gjersvik, G. Hedlin, Håvard Ove Skjerven, Riyas Vettukattil, Marissa LeBlanc, Anne Catherine Staff, Linn Landrø, Eva Maria Rehbinder, K. C. Lødrup Carlsen, Guttorm Haugen, Kim M Advocaat Endre, Cilla Söderhäll, Christine M. Jonassen, and Björn Nordlund
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Pediatrics ,medicine.medical_specialty ,business.industry ,Incidence ,Pruritus ,Incidence (epidemiology) ,Eczema ,Infant ,Clinical settings ,Dermatology ,Atopic dermatitis ,medicine.disease ,Dermatitis, Atopic ,Cohort Studies ,030207 dermatology & venereal diseases ,03 medical and health sciences ,0302 clinical medicine ,Clinical research ,medicine ,Multiple time ,Humans ,business ,Cohort study - Abstract
Summary Background Diagnosing atopic dermatitis (AD) in infants is challenging. Objectives To determine the incidence and persistence of eczema and AD in infants using the UK Working Party (UKWP) and Hanifin and Rajka (H&R) criteria. Methods A cohort of 1834 infants was examined clinically at 3, 6 and 12 months of age. AD was diagnosed by UKWP (3, 6 and 12 months) and H&R (12 months) criteria. Logistic regression models were used to assess the relationship between AD and eczema. Results Eczema was observed in 628 (34·2%) infants (n = 240, n = 359 and n = 329 at 3, 6 and 12 months, respectively), with AD diagnosed in 212 (33·7%) infants with any eczema and in 64/78 (82%) infants with eczema at all three visits. The odds of AD were lower with first presentation of eczema at 6 [odds ratio (OR) 0·33, 95% confidence interval (CI) 0·22–0·48] or 12 months (OR 0·49, 95% CI 0·32–0·74) than at 3 months, and higher in infants with eczema at three (OR 23·1, 95% CI 12·3–43·6) or two (OR 6·5, 95% CI 4·3–9·9) visits vs. one visit only. At 12 months, 156/329 (47·4%) fulfilled the UKWP and/or H&R criteria; 27 (8%) fulfilled the UKWP criteria only and 65 (20%) only the H&R criteria. Of the 129 infants who fulfilled the H&R criteria, 44 (34·1%) did not meet the itch criterion. Conclusions Used in combination and at multiple timepoints, the UKWP and H&R criteria for AD may be useful in clinical research but may have limited value in most other clinical settings.
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- 2022
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30. Long-term oncological safety of sentinel lymph node biopsy in early-stage cervical cancer: A post-hoc analysis of SENTICOL I and SENTICOL II cohorts
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Jean Lévêque, Virginie Fourchotte, Laurent Magaud, Eric Leblanc, Marc Baron, Philippe Morice, Benedetta Guani, Denis Querleu, Patrice Mathevet, Emile Daraï, Vincent Balaya, Henri Marret, Fabrice Lecuru, INSERM, Université de Lille, Protéomique, Réponse Inflammatoire, Spectrométrie de Masse (PRISM) - U1192, Centre Hospitalier Universitaire Vaudois [Lausanne] [CHUV], Institut Gustave Roussy [IGR], CHU Strasbourg, Institut Curie [Paris], CHU Tenon [AP-HP], Centre de Lutte Contre le Cancer Henri Becquerel Normandie Rouen [CLCC Henri Becquerel], Hôpital Bretonneau, Centre Hospitalier Universitaire [Rennes], Centre Hospitalier Lyon Sud [CHU - HCL] [CHLS], Centre Hospitalier Universitaire Vaudois [Lausanne] (CHUV), Institut Gustave Roussy (IGR), Département de chirurgie gynécologique [Gustave Roussy], Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Centre Régional de Lutte contre le Cancer Oscar Lambret [Lille] (UNICANCER/Lille), Université de Lille-UNICANCER, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Centre de Lutte Contre le Cancer Henri Becquerel Normandie Rouen (CLCC Henri Becquerel), Centre Hospitalier Régional Universitaire de Tours (CHRU Tours), CHU Pontchaillou [Rennes], and Hospices Civils de Lyon (HCL)
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Adult ,medicine.medical_specialty ,Multivariate analysis ,SENTICOL ,Sentinel lymph node ,Urology ,Uterine Cervical Neoplasms ,Oncologic outcomes ,Disease-Free Survival ,Cohort Studies ,Young Adult ,Risk Factors ,Post-hoc analysis ,Biopsy ,medicine ,Humans ,Prospective Studies ,Stage (cooking) ,Pelvic lymphadenectomy ,Aged ,Neoplasm Staging ,Proportional Hazards Models ,Aged, 80 and over ,Cervical cancer ,Risk level ,medicine.diagnostic_test ,Sentinel Lymph Node Biopsy ,business.industry ,Obstetrics and Gynecology ,Middle Aged ,medicine.disease ,Oncology ,Female ,Disease-free survival ,France ,business ,[SDV.MHEP]Life Sciences [q-bio]/Human health and pathology - Abstract
International audience; Objectives: To compare oncologic outcomes of patients with early-stage cervical cancer and negative nodes who underwent sentinel lymph node biopsy alone (SLNB) versus pelvic lymphadenectomy (PL).Methods: An ancillary analysis of two prospective multicentric trials on SLN biopsy for cervical cancer (SENTICOL I and II) was conducted. Only patients with early-stage cervical cancer (IA to IIA FIGO stage), bilateral detection of SLN, negative SLN after ultrastaging and negative non-SLN after final pathologic examination were included. Risk-factors of recurrence and disease-specific mortality were determined by Cox proportional hazard models.Results: Between January 2005 and July 2012, 259 node-negative patients were analyzed: 87 in the SLNB group and 172 in the PL group. The median follow-up was 47 months [4-127]. During the follow-up, 21 patients (8.1%) experienced recurrences, including 4 nodal recurrences (1.9%), and 9 patients (3.5%) died of cervical cancer. Disease-free survival (DFS) and disease-specific survival (DSS) were similar between SLNB and PL groups, 85.1% vs. 80.4%, p = 0.24 and 90.8% vs. 97.2%, p = 0.22 respectively. By Cox multivariate analysis, SLNB compared to PL was not associated with DFS (HR = 1.78, 95%CI = [0.71-4.46], p = 0.22) neither with DSS (HR = 3.02, 95%CI = [0.69-13.18], p = 0.14). Only pathologic risk level according to the Sedlis criteria was an independent predictor of DFS and DSS.Conclusions: Omitting full pelvic lymphadenectomy for patients with bilateral negative SLN does not seem to be associated with an increased risk of recurrence in this series. Survival non-inferiority needs to be confirmed by prospective trials.
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- 2022
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31. Management of Myeloma Manifestations and Complications: The Cornerstone of Supportive Care: Recommendation of the Canadian Myeloma Research Group (formerly Myeloma Canada Research Network) Consensus Guideline Consortium
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Martha L Louzada, Heather J. Sutherland, Debra J. Bergstrom, Richard Leblanc, Rami Kotb, and Julie Cote
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Canada ,Cancer Research ,medicine.medical_specialty ,Consensus ,business.industry ,Cornerstone ,Hematology ,Disease ,medicine.disease ,Patient care ,Quality of life (healthcare) ,Oncology ,hemic and lymphatic diseases ,Quality of Life ,Humans ,Medicine ,Multiple Myeloma ,business ,Intensive care medicine ,Multiple myeloma ,Consensus guideline - Abstract
Multiple myeloma (MM) is a hematological cancer associated with significant symptomatic burden. Bone disease, renal insufficiency, cytopenias, infection, and peripheral neuropathy, among other disease manifestations and complications, impair patients' quality of life. The Canadian Myeloma Research Group Consensus Guideline Consortium, formerly Myeloma Canada Research Network Consensus Guideline Consortium, proposes national consensus recommendations for the management of MM-related manifestations and complications. To address the needs of Canadian physicians and people living with MM across the country, this document focuses on the improvement and maintenance of patient care by clarifying best-practice approaches for the prevention, detection and management of disease manifestations and complications. The Canadian Myeloma Research Group Consensus Guideline Consortium will periodically review the recommendations herein and update as necessary.
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- 2022
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32. Heavy Burden of Toxic Dilated Cardiomyopathy Among Young Adults: A Retrospective Study and Review of the Literature
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Steve Radermaker, Christine Bourgault, Kim O'Connor, Eric Charbonneau, Marie-Ève Komlosy, Marie-Hélène Leblanc, Joëlle Morin, Sacha-Michelle Dubois-Sénéchal, Jonathan Beaudoin, Alexandre Cinq-Mars, Claudine Laliberté, Mario Sénéchal, Montse Massot, Mathieu Bernier, David Belzile, Sébastien Bergeron, Pierre Yves Turgeon, and Maxime Laflamme
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Cardiomyopathy, Dilated ,medicine.medical_specialty ,Substance-Related Disorders ,medicine.medical_treatment ,Cardiomyopathy ,Ventricular Function, Left ,Young Adult ,Internal medicine ,medicine ,Humans ,cardiovascular diseases ,Ventricular remodeling ,Retrospective Studies ,Ejection fraction ,Ventricular Remodeling ,business.industry ,Dilated cardiomyopathy ,Retrospective cohort study ,medicine.disease ,Transplantation ,Ventricular assist device ,Heart failure ,cardiovascular system ,Cardiology ,Heart-Assist Devices ,Cardiology and Cardiovascular Medicine ,business - Abstract
Background Dilated cardiomyopathy (DCM) is a well-described entity for heart failure (HF) with reduced left ventricular ejection fraction (LVEF). Recently, drugs and other substance of abuse have been recognized as potential triggers for DCM. The aim of this study was to assess the survival in patients under 65 years old with toxic cardiomyopathy (TCM). Left ventricular remodeling and the potential usefulness of left ventricular assist device (LVAD) was also assessed. Methods Single center retrospective study from January 2003 to August 2019 at a tertiary care cardiology center identified 553 patients younger than 65 years old with LVEF Results Two hundred and one patients (36%) had a diagnosis of idiopathic DCM. Further analysis identified 38 patients (19%) for which a TCM was the most likely etiology (amphetamine [50%], cocaine [37%], anabolic steroids [8%], and energy drinks [5%]). Despite a mean LVEF of 17±8% at presentation, most patients (n=27, 71%) had an event-free survival with guideline-directed medical therapy, and 61% (n=23) recovered a LVEF ≥40% after a median follow-up of 21±23 months. Seven patients (18%) required a LVAD and 1 (3%) patient a transplantation. All LVAD were explanted or decommissioned after a median support time of 11±4 months following partial or complete LVEF recovery. Conclusion TCM induced by substance abuse is a frequent cause of HF accounting for almost 20% of all patients with DCM of unknown etiology under 65 years of age. Treatment must be tailored on an individual basis. Mechanical circulatory support demonstrated its usefulness in carefully selected patients.
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- 2022
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33. Cross-sectional study of antimicrobial use and treatment decision for preweaning Canadian dairy calves
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Herman W. Barkema, Stephen J. LeBlanc, Luke C. Heider, Tamaki Uyama, Emma I. Morrison, Javier Sánchez, Charlotte B. Winder, Simon Dufour, David F. Kelton, David L. Renaud, J.T. McClure, Ellen de Jong, and Kayley D. McCubbin
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medicine.medical_specialty ,Cross-sectional study ,business.industry ,Disease ,Antimicrobial ,Diarrhea ,Antimicrobial use ,Internal medicine ,Herd ,medicine ,Antimicrobial stewardship ,Treatment decision making ,medicine.symptom ,business - Abstract
Antimicrobials should be used prudently in farm animals to prevent the development of resistant bacteria in both humans and animals. The objective of this study was to investigate Canadian dairy producers' practices for antimicrobial use in the treatment of disease in preweaning dairy calves. In-person questionnaires were administered to 144 dairy producers across 5 provinces in Canada between July 2019 and August 2020. Almost all (96%) producers used antimicrobials to treat calves with respiratory disease, but only 27% indicated they had a written treatment protocol for respiratory disease. Most (95%) of these protocols for respiratory disease were developed with input from the herd veterinarian. Seventy-four percent of producers used antimicrobials to treat calf diarrhea, with 37% of producers having a written treatment protocol for calf diarrhea with input from the herd veterinarian. The combinations of signs adopted by the producers for antimicrobial treatment in calf respiratory disease and diarrhea were evaluated based on findings from other studies. More than half (56%) of producers who used antimicrobials for calf respiratory disease decided to use antimicrobials by evaluating multiple clinical signs. Eighty-two percent of producers who used antimicrobials for calf diarrhea made decisions based on systemic signs of disease, presence of bloody stool, no response to previous treatment, or on the recommendation from the herd veterinarian. Producers with a written treatment protocol had 3 to 7 times greater odds of using antimicrobials based on multiple signs or systemic signs of disease compared with those without a protocol. Further research may investigate other calf management practices related to decision-making by producers in using antimicrobials to improve antimicrobial stewardship on dairy farms.
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- 2022
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34. Designer Scaffolds for Interfacial Bioengineering
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Andrew E. Pelling, James L. Harden, Ryan J. Hickey, and Maxime Leblanc Latour
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Decellularization ,Computer science ,business.industry ,Tissue integration ,Nanotechnology ,General Materials Science ,Modular design ,Biocompatible material ,business ,Condensed Matter Physics ,Regenerative medicine ,Engineered tissue - Abstract
In regenerative medicine, the healing of the interfacial zone between tissues is a major challenge, yet approaches for studying the complex microenvironment of this interface remain lacking. Here, we study these complex living interfaces by manufacturing modular “blocks” of naturally porous decellularized plant-derived scaffolds with a computer numerical controlled mill. We demonstrate how each scaffold can be seeded with different cell types and easily assembled in a manner akin to LEGO™ bricks to create an engineered tissue interface (ETI). Cells migrate across the interface formed between an empty scaffold and a scaffold pre-seeded with cells. However, when both scaffolds contain cells, only a shallow cross-over zone of cell infiltration forms at the interface. As a proof-of-concept study, we use ETIs to investigate the interaction between lab grown bone and connective tissues. Consistent with the above, a cross-over zone of the two distinct cell types forms at the interface between scaffolds, otherwise the populations remain distinct. Finally, we demonstrate how ETIs are biocompatible in vivo, becoming vascularized and integrated into surrounding tissue after implantation. This work creates new tissue design avenues for understanding biological processes or the development of synthetic artificial tissues.
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- 2023
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35. ASP, the art and science of practice: increasing productivity and minimizing errors in operations research spreadsheet models
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LeBlanc, Larry J., Bartolacci, Michael R., and Grossman, Thomas A.
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Best practices ,Spreadsheets -- Product enhancement ,Software engineering ,Spreadsheet add-on ,Software development/engineering ,Software architecture ,Modularity ,Spreadsheet software ,Product enhancement ,Business, general ,Business - Abstract
Abstract. Operations research practitioners often write spreadsheet software that is used, modified, and transferred to other people over time. They need techniques that enable them to quickly write error-free code [...]
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- 2017
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36. DARK PATTERNS DEEP DIVE: MISDIRECTION AND FORCED CONTINUITY
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Leblanc, Kelly
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Web sites -- Design and construction ,Business ,Library and information science - Abstract
This is the second installment of a series of deep dives on dark patterns, and it focuses on two major ones: misdirection and forced continuity. (See 'Dark Patterns Deep Dive: [...]
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- 2022
37. The ATLAS fast TracKer system
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Aad, Georges, Abbott, Braden Keim, Abreu, Henso, Arcangeletti, Chiara, Gutierrez Zagazeta, Luis Felipe, Gutschow, Christian, Guyot, Claude, Gwenlan, Claire, Gwilliam, Carl, Haaland, Even Simonsen, Haas, Andy, Haas, Andrew, Haber, Carl, Hadavand, Haleh, Arce, Ayana Tamu, Hadef, Asma, Haleem, Mahsana, Haley, Joseph, Hall, Jack Joseph, Halladjian, Garabed, Hallewell, Gregory, Hamano, Kenji, Hamdaoui, Hassane, Hamer, Matthias, Hamity, Guillermo Nicolas, Arguin, Jean-francois, Han, Kunlin, Han, Liangliang, Han, Liang, Han, Shuo, Han, Yi Fei, Hanagaki, Kazunori, Hance, Mike, Hank, Michael Donald, Hankache, Robert, Hansen, Eva Brottmann, Argyropoulos, Spyros, Hansen, Jorgen Beck, Hansen, Dines, Hansen, Maike Christina, Hansen, Peter, Hanson, Emily Claire, Hara, Kazuhiko, Harenberg, Torsten, Harkusha, Siarhei, Harrison, Paul Fraser, Hartman, Nicole Michelle, Arling, Jan-hendrik, Hartmann, Nikolai, Hasegawa, Yoji, Hasib, Ahmed, Hasley, Lloyd Alan, Hassani, Samira, Haug, Sigve, Hauser, Reiner, Havranek, Miroslav, Hawkes, Chris, Hawkings, Richard, Armbruster, Aaron James, Hayashida, Shota, Hayden, Daniel, Hayes, Christopher Robyn, Hayes, Robin, Hays, Chris, Hays, Jonathan, Hayward, Helen, Haywood, Stephen, He, Fudong, He, Yunjian, Armstrong, Alexander, Heath, Matthew Peter, Hedberg, Vincent, Heggelund, Andreas Lokken, Hehir, Natasha, Heidegger, Constantin, Heidegger, Kim Katrin, Heidorn, William Dale, Heilman, Jesse Alan, Heim, Sarah, Heim, Timon, Arnaez, Olivier, Heinemann, Beate, Heinlein, James Geddy, Heinrich, Jochen Jens, Heinrich, Lukas Alexander, Hejbal, Jiri, Helary, Louis, Held, Alexander, Hellesund, Simen, Helling, Cole Michael, Hellman, Sten, Arnold, Hannah, Helsens, Clement, Henderson, Robert, Henkelmann, Lars, Henriques Correia, Ana Maria, Herde, Hannah Elizabeth, Hernandez Jimenez, Yesenia, Herr, Holger Arnold, Herrmann, Maximilian Georg, Herrmann, Tim, Herten, Gregor, Arrubarrena Tame, Zulit Paola, Hertenberger, Ralf, Hervas, Luis, Hessey, Nigel, Hibi, Hiroaki, Higashino, Satoshi, Higon-rodriguez, Emilio, Hildebrand, Kevin, Hill, John, Hill, Kurt Keys, Hiller, Karl Heinz, Abulaiti, Yiming, Artoni, Giacomo, Hu, Yi Fan, Hiller, Karlheinz, Hillier, Stephen, Hils, Maximilian, Hinchliffe, Ian, Hinterkeuser, Florian, Hirose, Minoru, Hirose, Shigeki, Hirschbuehl, Dominic, Hiti, Bojan, Asada, Haruka, Hladik, Ondrej, Hobbs, John David, Hobincu, Radu, Tal Hod, Noam, Hodgkinson, Mark, Hoecker, Andreas, Hohn, David, Hohov, Dmytro, Holm, Tanja, Holmes, Tova, Asai, Kanae, Holzbock, Michael, Hommels, Bart, Hong, Tae Min, Honig, Jan Cedric, Honle, Andreas, Hooberman, Benjamin Henry, Hopkins, Walter, Horii, Yasuyuki, Horn, Philipp, Horyn, Lesya Anna, Asai, Shoji, Hou, Suen, Howarth, James William, Hoya, Joaquin, Hrabovsky, Miroslav, Hrynevich, Aliaksei, Hrynova, Tetiana, Hsu, Pai-hsien, Hsu, Shih-chieh, Hu, Qipeng, Hu, Shuyang, Asawatavonvanich, Thanawat, Iakovidis, Georgios, Hu, Yifan, Huang, Danping, Huang, Xiaozhong, Huang, Yicong, Huang, Yanping, Hubacek, Zdenek, Hubaut, Fabrice, Hubner, Michael, Huegging, Fabian, Asbah, Nedaa Alexandra, Huffman, Todd Brian, Huhtinen, Mika, Hulsken, Raphael, Hunter, Robert Francis, Husejko, Michal, Huseynov, Nazim, Huston, Joey, Huth, John, Hyneman, Rachel Jordan, Hyrych, Sofiia, Asimakopoulou, Eleni Myrto, Iacobucci, Giuseppe, Iakovidis, George, Ibragimov, Iskander, Iconomidou-fayard, Lydia, Iengo, Paolo, Ignazzi, Rosanna, Iguchi, Ryunosuke, Iizawa, Tomoya, Ikegami, Yoichi, Ilic, Nikolina, Asquith, Lily, Imam, Hajar, Introzzi, Gianluca, Iodice, Mauro, Iordanidou, Kalliopi, Ippolito, Valerio, Isacson, Max Fredrik, Ishino, Masaya, Islam, Wasikul, Issever, Cigdem, Istin, Serhat, Assahsah, Jihad, Ito, Hiroki, Iturbe, Julia, Iuppa, Roberto, Ivina, Anna, Izen, Joseph Michael, Izzo, Vincenzo, Jacka, Petr, Jackson, Paul, Jacobs, Ruth Magdalena, Jaeger, Benjamin Paul, Assamagan, Ketevi Adikle, Jakel, Gunnar, Jakobi, Katharina Bianca, Jakobs, Karl, Jakoubek, Tomas, Jamieson, Jonathan, Janas, Krzysztof, Jansky, Roland, Janus, Piotr Andrzej, Jarlskog, Goran, Jaspan, Adam Elliott, Acharya, Bobby Samir, Astalos, Robert, Javadov, Namig, Javurek, Tomas, Javurkova, Martina, Jeanneau, Fabien, Jeanty, Laura, Jejelava, Juansher, Jenni, Peter, Jezequel, Stephane, Jia, Jiangyong, Jia, Zihang, Atkin, Ryan Justin, Jiang, Yi, Jiggins, Stephen, Jimenez Morales, Fabricio Andres, Jimenez Pena, Javier, Jin, Shan, Jinaru, Adam, Jinnouchi, Osamu, Jivan, Harshna, Johansson, Per Daniel Conny, Johns, Kenneth, Atkinson, Markus Julian, Johnson, Christian, Jones, Eleanor, Jones, Roger, Jones, Samuel David, Jones, Tim, Joos, Markus, Jovicevic, Jelena, Ju, Xiangyang, Junggeburth, Johannes Josef, Juste Rozas, Aurelio, Atlay, Naim Bora, Kaczmarska, Anna, Kado, Marumi, Kagan, Harris, Kagan, Michael Aaron, Kahn, Alan Mathew, Kahra, Christian, Kaji, Toshiaki, Kajomovitz Must, Enrique, Kalderon, Charles William, Kartvelishvili, Vakhtang, Atmani, Hicham, Kalderon, Will, Kaluza, Adam, Kamenshchikov, Andrey, Kaneda, Michiru, Kang, Nathan Jihoon, Kang, Shuaiyan, Kano, Yuya, Kanzaki, Junichi, Kar, Deepak, Karava, Kla, Atmasiddha, Prachi, Kareem, Mohammad, Karkanias, Ioannis, Karpov, Sergey, Karpova, Zoya, Kaya, Fikriye Idil, Kartvelishvili, Vato, Karyukhin, Andrei, Kasimi, Eirini, Kastanas, Alex, Kasten, Michael Scott, Augsten, Kamil, Kato, Chikuma, Katzy, Judith, Kawade, Kentaro, Kawagoe, Kiyotomo, Kawaguchi, Tomomi, Kawaguchi, Yoshimasa, Kawamoto, Tatsuo, Kawamura, Gen, Kay, Ellis, Kaya, Colette, Austrup, Volker Andreas, Kazakos, Stergios, Kazanin, Vassili, Keaveney, James Michael, Keeler, Richard, Keller, John Stakely, Kelsey, Daniel Christopher, Kempster, Jacob Julian, Kendrick, James Andrew, Kennedy, Kiley Elizabeth, Kepka, Oldrich, Avolio, Giuseppe, Kersten, Susanne, Kersevan, Borut Paul, Ketabchi, Sana, Khalil-zada, Farhad, Khandoga, Mykola, Khanov, Alexander, Kharlamov, Alexey, Kharlamova, Tatyana, Khoda, Elham E, Khoo, Teng Jian, Ayoub, Mohamad Kassem, Khoriauli, Gia, Khramov, Evgeny, Khubua, Djemal, Kido, Shogo, Kiehn, Moritz, Kilgallon, Aaron Joseph, Kim, Eunchong, Kim, Young-kee, Kimura, Naoki, Kirchhoff, Andreas, Achkar, Baida, Azuelos, Georges, Kirchmeier, David, Kirk, Julie, Kiryunin, Andrei, Kishimoto, Tomoe, Kisliuk, Dylan Perry, Kitali, Vincent, Kitsaki, Chara, Kivernyk, Oleh, Klapdor-kleingrothaus, Thorwald, Klassen, Martin, Babal, Dominik, Klein, Christoph Thomas, Klein, Lucas, Klein, Matthew Henry, Klein, Max, Klein, Uta, Klimek, Pawel Jan, Klimentov, Alexei, Klimpel, Fabian, Klingl, Tobias, Klioutchnikova, Tatiana, Bachacou, Henri, Klitzner, Felix Fidelio, Kluit, Peter, Kluth, Stefan, Kneringer, Emmerich, Knoops, Edith, Knue, Andrea Helen, Kobayashi, Dai, Kobel, Michael, Kocian, Martin, Kodama, Takafumi, Bachas, Dinos, Kodys, Peter, Kock, Daniela, Konig, Philipp, Koffas, Thomas, Koehler, Nicolas, Kolb, Mathis, Koletsou, Iro, Komarek, Tomas, Koeneke, Karsten, Kong, Albert, Backman, Karl Filip, Kono, Takanori, Konstantinides, Vasilis, Konstantinidis, Nikolaos, Konya, Balazs, Kopeliansky, Revital, Koperny, Stefan Zenon, Korcyl, Krzysztof Marian, Kordas, Konstantinos, Kowalewski, Robert Victor, Kordas, Kostas, Bagnaia, Paolo, Koren, Guy, Korn, Andreas, Korolkov, Ilya, Korolkova, Elena, Korotkova, Natalia, Kortner, Oliver, Kortner, Sandra, Kostyukhin, Vadim, Kotsokechagia, Anastasia, Kotwal, Ashutosh, Bahrasemani, Sina, Koulouris, Aimilianos, Kourkoumeli-charalampidi, Athina, Kourkoumelis, Christine, Kourlitis, Evangelos, Kowalewski, Bob, Kozanecki, Witold, Kozhin, Anatoli, Kramarenko, Viktor, Kramberger, Gregor, Krasnopevtsev, Dimitrii, Bailey, Adam, Krasny, Mieczyslaw, Krasznahorkay, Attila, Kremer, Jakub, Kretzschmar, Jan, Kreul, Ken Matthias, Krieger, Peter, Krieter, Ferdinand, Krishnamurthy, Samyukta, Krishnan, Anjali, Krivos, Martin, Bailey, Virginia, Krizka, Karol, Kroeninger, Kevin Alexander, Kroha, Hubert, Kroll, Jiri, Kroll, Joe, Kulchitsky, Yuri, Kuleshov, Sergey, Kroll, Joseph Ira, Krowpman, Kyle Stuart, Kruchonak, Uladzimir, Baines, John, Krueger, Hans, Krumnack, Nils Erik, Kruse, Mark, Krzysiak, Janina Anna, Kubota, Arisa, Kuchinskaia, Olesia, Kuday, Sinan, Kuchler, Daniela, Kuechler, Jan, Kuehn, Susanne, Adam, Lennart, Bakalis, Christos, Kuhl, Thorsten, Kukhtin, Victor, Koultchitski, Yuri, Kuleshov, Serguei, Kulinich, Yakov Petrovich, Kumar, Mukesh, Kuna, Marine, Kupco, Alexander, Kupfer, Tobias, Kuprash, Oleg, Baker, Keith, Kurashige, Hisaya, Kurchaninov, Leonid, Kurochkin, Yurii, Kurova, Anastasia, Kurth, Matthew Glenn, Kuwertz, Emma Sian, Kuze, Masahiro, Kvam, Audrey Katherine, Kvita, Jiri, Kwan, Tony, Bakker, Pepijn Johannes, Lacasta Llacer, Carlos, Lacava, Francesco, Lack, David Philip John, Lacker, Heiko Markus, Lacour, Didier, Ladygin, Evgueni, Lafaye, Remi, Laforge, Bertrand, Lagouri, Theodota, Lai, Stanley, Bakos, Evelin, Lai, Stan, Lakomiec, Inga Katarzyna, Lambert, Joseph Earl, Lammers, Sabine Wedam, Lampl, Walter, Lampoudis, Christos, Lancon, Eric Christian, Landgraf, Ulrich, Landon, Murrough, Lang, Valerie, Bakshi Gupta, Debottam, Lange, Joern, Langenberg, Robert Johannes, Lankford, Andrew James, Lanni, Francesco, Lantzsch, Kerstin, Lanza, Agostino, Lapertosa, Alessandro, Laporte, Jean-francois, Lari, Tommaso, Lasagni Manghi, Federico, Balaji, Shyam, Lassnig, Mario, Latonova, Vera, Lau, Tak Shun, Laudrain, Antoine, Laurier, Alexandre, Lavorgna, Marco, Lawlor, Sean Dean, Lazzaroni, Massimo, Le, Brian, Le Guirriec, Emmanuel, Balasubramanian, Rahul, Lebedev, Alexandre, Leblanc, Matthew Edgar, LeCompte, Thomas, Leblanc, Matt, Le Compte, Tom, Ledroit, Fabienne, Lee, Ava Chloe Audrey, Lee, Claire, Lee, Graham Richard, Lee Jr, Lawrence, Baldin, Evgenii, Lee, Shih-chang, Lee, Songkyo, Lefebvre, Benoit, Lefebvre, Helena, Lefebvre, Michel, Leggett, Charles, Lehmann, Konstantin, Lehmann, Niklaus, Lehmann Miotto, Giovanna, Leight, William Axel, Balek, Petr, Leisos, Antonios, Lisboa Leite, Marco, Leitgeb, Clara Elisabeth, Leitner, Rupert, Leney, Katharine, Lenz, Tatjana, Leone, Sandra, Leonidopoulos, Christos, Leopold, Alexander, Leroy, Claude, Balli, Fabrice, Les, Robert, Lester, Christopher, Levchenko, Mikhail, Leveque, Jessica, Levin, Daniel, Levin, Dan, Levinson, Lorne, Lewis, Daniel James, Li, Boyang, Li, Bing, Adam Bourdarios, Claire, Balunas, William Keaton, Li, Changqiao, Li, Fan, Li, Heng, Li, Haifeng, Li, Jing, Li, Ke, Li, Liang, Li, Mengran, Li, Quanyin, Li, Shu, Balz, Johannes, Li, Xingguo, Li, Yichen, Li, Zhi, Li, Zhiying, Li, Zhelun, Li, Zhiyuan, Liang, Zhijun, Liberali, Valentino, Liberatore, Marianna, Liberti, Barbara, Banas, Elzbieta, Lie, Ki, Lim, Sanghoon, Lin, Chiao-ying, Lin, Kuan-yu, Linck, Rebecca, Lindley, Rachel Elizabeth, Lindon, Jack, Linss, Arthur, Lionti, Anthony, Lipeles, Elliot, Bandieramonte, Marilena, Lipniacka, Anna, Lisovyi, Mykhailo, Liss, Tony, Liss, Anthony Michael, Lister, Alison, Little, Jared, Liu, Bo, Liu, Bingxuan, Liu, Jianbei, Liu, Jesse, Bandyopadhyay, Anjishnu, Liu, Kun, Liu, Minghui, Liu, Mingyi, Liu, Peilian, Liu, Xiaotian, Liu, Yi, Liu, Yang, Liu, Yanlin, Liu, Yanwen, Livan, Michele, Barak, Liron, Lleres, Annick, Llorente Merino, Javier, Lloyd, Stephen, Lloyd, Steve, Lobodzinska, Ewelina Maria, Loch, Peter, Loffredo, Salvatore, Lohse, Thomas, Lohwasser, Kristin, Lokajicek, Milos, Barbe, William Mickael, Long, Jonathan, Long, Robin Eamonn, Longarini, Iacopo, Longo, Luigi, Longo, Riccardo, Lopez Paz, Ivan, Lopez Solis, Alvaro, Lorenz, Jeanette Miriam, Lorenzo Martinez, Narei, Lory, Alexander, Barberio, Elisabetta, Loesle, Alena, Lou, Xuanhong, Lou, Xinchou, Lounis, Abdenour, Love, Jeremy Robert, Love, Peter, Lozano Bahilo, Julio, Lu, Miaoran, Lu, Sicong, Lu, Yun-ju, Barberis, Dario, Lubatti, Henry, Luci, Claudio, Lucio Alves, Fabio Lucio, Lucotte, Arnaud, Luehring, Fred, Luise, Ilaria, Luminari, Lamberto, Lund-jensen, Bengt, Luongo, Nicholas, Lutz, Margaret Susan, Barbero, Marlon Benoit, Lynn, David, Lyons, Harry John, Lysak, Roman, Lytken, Else, Lyu, Feng, Lyubushkin, Vladimir, Lyubushkina, Tatiana, Ma, Hong, Ma, Lianliang, Ma, Yanhui, Adamczyk, Leszek, Barbour, Gregory, Macdonell, Danika Marina, Maccarrone, Giovanni, Macdonald, Calum Michael, Macdonald, Jack, Machado Miguens, Joana, Madar, Romain, Mader, Wolfgang, Madugoda Ralalage Don, Madhuranga, Madysa, Nico, Maeda, Junpei, Barillari, Teresa, Maeno, Tadashi, Maerker, Max, Magerl, Veronika, Magro, Jacopo, Mahon, Devin, Maidantchik, Carmen, Maio, Amelia, Maj, Klaudia, Majersky, Oliver, Majewski, Stephanie, Barisits, Martin, Makovec, Nikola, Malaescu, Bogdan, Malecki, Pawel, Maleev, Victor, Malek, Fairouz, Malito, Davide, Mallik, Usha, Malone, Claire, Maltezos, Stavros, Malyukov, Sergey, Barkeloo, Jason Tyler Colt, Mamuzic, Judita, Mancini, Giada, Mandalia, Jesal, Mandic, Igor, Manhaes De Andrade Filho, Luciano, Maniatis, Ioannis Michail, Manjarres, Joany, Mankinen, Katja Hannele, Mann, Alexander, Manousos, Athanasios, Barklow, Tim, McCarthy, Tom, McDonald, Emily, Manousos, Thanos, Mansoulie, Bruno, Manthos, Ioannis, Manzoni, Stefano, Marantis, Alexandros, Marchese, Luigi, Marchiori, Giovanni, Marcisovsky, Michal, Barnett, Bruce M, Marcoccia, Lorenzo, Marcon, Caterina, Marjanovic, Marija, Marshall, Zach, Martensson, Mikael, Marti I Garcia, Salvador, Martin, Tim, Martin, Victoria, Martin Dit Latour, Bertrand, Martinelli, Luca, Barnett, Michael, Martinez-perez, Mario, Martinez Agullo, Pablo, Martinez Outschoorn, Verena Ingrid, Martin-haugh, Stewart, Martoiu, Sorin, Martyniuk, Alex Christopher, Marzin, Antoine, Maschek, Stefan Raimund, Masetti, Lucia, Mashimo, Tetsuro, Blenessy, Zuzana, Mashinistov, Ruslan, Masik, Jiri, Maslennikov, Alexei, Massa, Lorenzo, Massarotti, Paolo, Mastrandrea, Paolo, Mastroberardino, Anna, Masubuchi, Tatsuya, Matakias, Dimitrios, Mathisen, Thomas, Baroncelli, Toni, Matic, Andrea, Matsuzawa, Nobuo, Maurer, Julien, Macek, Bostjan, Maximov, Dmitriy, Mazini, Rachid, Maznas, Ioannis, Mazza, Simone Michele, Mc Ginn, Christopher, Mc Gowan, John Patrick, Barone, Gaetano, Mc Kee, Shawn, Mcfayden, Joshua Angus, McPherson, Robert, Mikenberg, Giora, Mccarthy, Thomas, Mccormack, William Patrick, Milke, Christopher Don, Mina, Robert Arthur, Mcdonald, Millie, Mcdougall, Ashley Ellen, Adamek, Lukas, Barr, Alan, Mcfayden, Josh, Mchedlidze, Gvantsa, Mc Kay, Maddie, Mclean, Kayla, Mcmahon, Stephen, Mcnamara, Peter Charles, Mcnicol, Christopher John, Mcpherson, Rob, Mdhluli, Joyful Elma, Meadows, Zachary Alden, Barranco Navarro, Laura, Meehan, Samuel Ross, Megy, Theo, Mehlhase, Sascha, Mehta, Andrew, Meirose, Bernhard, Melini, Davide, Mellado Garcia, Bruce, Meloni, Federico, Melzer, Alexander, Gouveia, Emanuel, Barreiro Alonso, Fernando, Mendes Jacques Da Costa, Antonio Manuel, Meng, Huan Yu, Meng, Lingxin, Menke, Sven, Meoni, Evelin, Mergelmeyer, Sebastian, Merkt, Sebastian Andreas, Merlassino, Claudia, Mermod, Philippe, Merola, Leonardo, Barreiro Guimaraes Da Costa, Joao, Meroni, Chiara, Merz, Garrett William, Meshkov, Oleg, Meshreki, John Kamal Rizk, Metcalfe, Jessica, Mete, Alaettin Serhan, Meyer, Christopher John, Meyer, Jean-pierre, Michetti, Michele, Middleton, Robin, Barron, Uriel, Mijovic, Liza, Mikenberg, George, Mikestikova, Marcela, Mikuz, Marko, Mildner, Hannes, Milic, Adriana, Milke, Chris, Miller, David, Miller, Laura Stephanie, Milov, Alexander, Barsov, Sergey, Milstead, David Anthony, Mina, Rob, Minaenko, Andrei, Minashvili, Irakli, Mince, Laurynas, Mincer, Allen Irving, Mindur, Bartosz, Mineev, Mikhail, Minegishi, Yuji, Mino, Yuya, Bartels, Falk, Mir Martinez, Lluisa Maria, Mironova, Maria, Mitani, Takashi, Mitrevski, Jovan, Mitsou, Vasiliki, Mittal, Monika, Miu, Ovidiu, Miucci, Antonio, Miyagawa, Paul, Mizukami, Atsushi, Bartoldus, Rainer, Mjoernmark, Jan-ulf, Mkrtchyan, Tigran, Mlynarikova, Michaela, Moa, Torbjorn, Mobius, Silke, Mochizuki, Kazuya, Moder, Paul, Mogg, Philipp, Mohapatra, Soumya, Mokgatitswane, Gaogalalwe, Bartolini, Giovanni, Momiyama, Keisuke, Mondal, Buddhadeb, Mondal, Santu, Monig, Klaus, Monnier, 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Pierre-francois, Giugliarelli, Gilberto, Giugni, Danilo, Giuli, Francesco, Gkaitatzis, Stamatios, Gkialas, Ioannis, Gkougkousis, Evangelos, Antrim, Daniel Joseph, Gkougkousis, Vagelis, Gkountoumis, Panagiotis, Gladilin, Leonid, Glasman, Claudia, Glaysher, Paul, Gledhill, Galen Rhodes, Gnesi, Ivan, Goblirsch-kolb, Maximilian Emanuel, Godin, Dominique, Goldfarb, Steven, Anulli, Fabio, Golling, Tobias, Golubkov, Dmitry, Da Silva Gomes, Agostinho, Goncalves Gama, Rafael, Morais Silva Goncalo, Ricardo Jose, Gonella, Giulia, Gonella, Laura, Gongadze, Alexi, Gonnella, Francesco, Gonski, Julia Lynne, Aoki, Masato, Gonzalez De La Hoz, Santiago, Gonzalez Fernandez, Sergio, Gonzalez Lopez, Ricardo, Gonzalez Renteria, Cesar, Gonzalez Suarez, Rebeca, Gonzalez Sevilla, Sergio, Gonzalvo Rodriguez, Galo Rafael, Goossens, Luc, Gorasia, Nandish Arjan, Gorbounov, Petr, Aparisi Pozo, Javier Alberto, Gordon, Howard, Gorini, Benedetto, Gorini, Edoardo, Gorisek, Andrej, Goshaw, Alfred, Grillo, Alexander, Goshaw, Al, Gostkin, Mikhail, Gottardo, Carlo Alberto, Gouighri, Mohamed, Aparo, Marco, Goussiou, Anna, Govender, Nicolin, Goy, Corinne, Grabowska-bold, Iwona, Gramstad, Eirik, Grancagnolo, Sergio, Grandi, Mario, Grachev, Vadim, Gravila, Paul, Gravili, Francesco Giuseppe, Aperio Bella, Ludovica, Gray, Chloe, Gray, Heather, Green, Barry, Grefe, Christian, Gregor, Ingrid, Grenier, Philippe, Grevtsov, Kirill, Grieco, Chiara, Grieser, Nathan Allen, Grillo, Alex, Aranzabal Barrio, Nordin, Grimm, Kathryn, Grinstein, Sebastian, Grivaz, Jean-francois, Groh, Sabrina, Gross, Eilam, Grosse-knetter, Joern, Grout, Zara Jane, Grud, Christopher Ryan, Grummer, Aidan, Grundy, James Cameron, Araujo Ferraz, Victor, Guan, Liang, Guan, Wen, Gubbels, Chris, Guenther, Jaroslav, Gubbels, Christopher, Guerrero Rojas, Jesus, Guescini, Francesco, Guest, Dan, Guest, Daniel, Gugel, Ralf, Pereira, Rodrigo, Guida, Alessandro, Guillemin, Thibault, Guindon, Stefan, Guo, Jun, Guo, Ziyu, Gupta, Ruchi, Gurbuz, Saime, Gustavino, Giuliano, Guth, Manuel, Gutierrez, Phillip, Aad, G, Bachas, K, Chiodini, G, Gorini, E, Gravili, F, Longo, L, Primavera, M, Reale, M, Schioppa, E, Spagnolo, S, Ventura, A, ATLAS Collaboration, And, Centre de Physique des Particules de Marseille (CPPM), Aix Marseille Université (AMU)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Laboratoire d'Annecy de Physique des Particules (LAPP), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Physique des 2 Infinis Irène Joliot-Curie (IJCLab), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Physique de Clermont (LPC), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Université Clermont Auvergne (UCA), Institut de Recherches sur les lois Fondamentales de l'Univers (IRFU), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Laboratoire de Physique Nucléaire et de Hautes Énergies (LPNHE (UMR_7585)), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Physique Subatomique et de Cosmologie (LPSC), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP ), Université Grenoble Alpes (UGA), Centre de Calcul de l'IN2P3 (CC-IN2P3), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), ATLAS, Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), De Castro , S., Fabbri , L., Gabrielli , A., Rinaldi , L., Semprini Cesari , N., Sioli , M., Villa , M., Zoccoli , A., Bellagamba , L., Boscherini , D., Bruni , A., Bruni , G., Giacobbe , B., Polini , A., Sbarra , C., Sidoti , A., Franchini , M., Romano , M., Valentinetti , S., Alberghi , G. L., Lasagni Manghi , F, Massa , L., Vittori , C., Alfonsi , F, Cabras , G., Cervelli , A., Negrini , M., Todome , K., Carratta , G., Cavalli , N., Clissa , L., ATLAS collaboration, Aad, G., Abbott, B., Abbott, D. C., Abud, A. A., Abeling, K., Abhayasinghe, D. K., Abidi, S. H., Abouzeid, O. S., Abraham, N. L., Abramowicz, H., Abreu, H., Abulaiti, Y., Acharya, B. S., Achkar, B., Adam, L., Bourdarios, C. A., Adamczyk, L., Adamek, L., Adelman, J., Adiguzel, A., Adorni, S., Adye, T., Affolder, A. A., Afik, Y., Agapopoulou, C., Agaras, M. N., Aggarwal, A., Agheorghiesei, C., Aguilar-Saavedra, J. A., Ahmad, A., Ahmadov, F., Ahmed, W. S., Ai, X., Aielli, G., Akatsuka, S., Akbiyik, M., Akesson, T. P. A., Akilli, E., Akimov, A. V., Al Khoury, K., Alberghi, G. L., Albert, J., Albicocco, P., Verzini, M. J. A., Alderweireldt, S., Aleksa, M., Aleksandrov, I. N., Alexa, C., Alexopoulos, T., Alfonsi, A., Alfonsi, F., Alhroob, M., Ali, B., Ali, S., Aliev, M., Alimonti, G., Alison, J., Allaire, C., Allbrooke, B. M. M., Allport, P. P., Aloisio, A., Alonso, F., Alpigiani, C., Camelia, E. A., Estevez, M. A., Alviggi, M. G., Coutinho, Y. A., Ambler, A., Ambroz, L., Amelung, C., Amidei, D., Dos Santos, S. P. A., Amoroso, S., Amrouche, C. S., Anastopoulos, C., Andari, N., Andeen, T., Anders, J. K., Anderson, J. T., Andrean, S. Y., Andreazza, A., Andrei, V., Anelli, C. R., Angelidakis, S., Angerami, A., Anisenkov, A. V., Annovi, A., Antel, C., Anthony, M. T., Antipov, E., Antonelli, M., Antrim, D. J. A., Anulli, F., Aoki, M., Pozo, J. A. A., Aparo, M. A., Bella, L. A., Aranzabal, N., Ferraz, V. A., Pereira, R. A., Arcangeletti, C., Arce, A. T. H., Arguin, J. -F., Argyropoulos, S., Arling, J. -H., Armbruster, A. J., Armstrong, A., Arnaez, O., Arnold, H., Tame, Z. P. A., Artoni, G., Asada, H., Asai, K., Asai, S., Asawatavonvanich, T., Asbah, N., Asimakopoulou, E. M., Asquith, L., Assahsah, J., Assamagan, K., Astalos, R., Atkin, R. J., Atkinson, M., Atlay, N. B., Atmani, H., Atmasiddha, P. A., Augsten, K., Austrup, V. A., Avolio, G., Ayoub, M. K., Azuelos, G., Babal, D., Bachacou, H., Bachas, K., Backman, F., Bagnaia, P., Bahmani, M., Bahrasemani, H., Bailey, A. J., Bailey, V. R., Baines, J. T., Bakalis, C., Baker, O. K., Bakker, P. J., Bakos, E., Gupta, D. B., Balaji, S., Balasubramanian, R., Baldin, E. M., Balek, P., Balli, F., Balunas, W. K., Balz, J., Banas, E., Bandieramonte, M., Bandyopadhyay, A., Barak, L., Barbe, W. M., Barberio, E. L., Barberis, D., Barbero, M., Barbour, G., Barillari, T., Barisits, M. -S., Barkeloo, J., Barklow, T., Barnett, B. M., Barnett, R. M., Barnovska-Blenessy, Z., Baroncelli, A., Barone, G., Barr, A. J., Navarro, L. B., Barreiro, F., da Costa, J. B. G., Barron, U., Barsov, S., Bartels, F., Bartoldus, R., Bartolini, G., Barton, A. E., Bartos, P., Basalaev, A., Basan, A., Bassalat, A., Basso, M. J., Basson, C. R., Bates, R. L., Batlamous, S., Batley, J. R., Batool, B., Battaglia, M., Bauce, M., Bauer, F., Bauer, P., Bawa, H. S., Bayirli, A., Beacham, J. B., Beau, T., Beauchemin, P. H., Becherer, F., Bechtle, P., Beck, H. P., Becker, K., Becot, C., Beddall, A., Beddall, A. J., Bednyakov, V. A., Bee, C. P., Beermann, T. A., Begalli, M., Begel, M., Behera, A., Behr, J. K., Beisiegel, F., Belfkir, M., Bella, G., Bellagamba, L., Bellerive, A., Bellos, P., Beloborodov, K., Belotskiy, K., Belyaev, N. L., Benchekroun, D., Benekos, N., Benhammou, Y., Benjamin, D. P., Benoit, M., Bensinger, J. R., Bentvelsen, S., Beresford, L., Beretta, M., Berge, D., Kuutmann, E. B., Berger, N., Bergmann, B., Bergsten, L. J., Beringer, J., Berlendis, S., Bernardi, G., Bernius, C., Bernlochner, F. U., Berry, T., Berta, P., Berthold, A., Bertram, I. A., Bylund, O. B., Bethke, S., Betti, A., Bevan, A. J., Bhatta, S., Bhattacharya, D. S., Bhattarai, P., Bhopatkar, V. S., Bi, R., Bianchi, R. M., Biebel, O., Biedermann, D., Bielski, R., Bierwagen, K., Biesuz, N. V., Biglietti, M., Billoud, T. R. V., Bindi, M., Bingul, A., Bini, C., Biondi, S., Birch-Sykes, C. J., Birman, M., Bisanz, T., Biswal, J. P., Biswas, D., Bitadze, A., Bittrich, C., Bjorke, K., Blair, R. E., Blazek, T., Bloch, I., Blocker, C., Blue, A., Blumenschein, U., Bobbink, G. J., Bobrovnikov, V. S., Bogavac, D., Bogdan, M., Bogdanchikov, A. G., Bohm, C., Boisvert, V., Bokan, P., Bold, T., Bomben, M., Bona, M., Bonilla, J. S., Boonekamp, M., Booth, C. D., Borbely, A. G., Borecka-Bielska, H. M., Borgna, L. S., Borisov, A., Borissov, G., Bortoletto, D., Boscherini, D., Bosman, M., Sola, J. D. B., Bouaouda, K., Boudreau, J., Bouhova-Thacker, E. V., Boumediene, D., Bouquet, R., Bourlis, G., Boveia, A., Boyd, J., Boye, D., Boyko, I. R., Bozson, A. J., Bracinik, J., Brahimi, N., Brandt, G., Brandt, O., Braren, F., Brau, B., Brau, J. E., Madden, W. D. B., Brendlinger, K., Brener, R., Brenner, L., Brenner, R., Bressler, S., Brickwedde, B., Briglin, D. L., Britton, D., Britzger, D., Brock, I., Brock, R., Brooijmans, G., Brooks, W. K., Brost, E., de Renstrom, P. A. B., Bruers, B., Bruncko, D., Bruni, A., Bruni, G., Bruschi, M., Bruscino, N., Bryant, P., Bryngemark, L., Buanes, T., Buat, Q., Buchholz, P., Buckley, A. G., Budagov, I. A., Bugge, M. K., Bulekov, O., Bullard, B. A., Burch, T. J., Burdin, S., Burgard, C. D., Burger, A. M., Burghgrave, B., Burr, J. T. P., Burton, C. D., Burzynski, J. C., Buscher, V., Buschmann, E., Bussey, P. J., Butler, J. M., Buttar, C. M., Butterworth, J. M., Buttinger, W., Vazquez, C. J. B., Buzykaev, A. R., Cabras, G., Urban, S. C., Caforio, D., Cai, H., Cairo, V. M. M., Cakir, O., Calace, N., Calafiura, P., Calderini, G., Calfayan, P., Callea, G., Caloba, L. P., Caltabiano, A., Lopez, S. C., Calvet, D., Calvet, S., Calvet, T. P., Calvetti, M., Toro, R. C., Camarda, S., Munoz, D. C., Camarri, P., Camerlingo, M. T., Cameron, D., Camincher, C., Campana, S., Campanelli, M., Camplani, A., Canale, V., Canesse, A., Bret, M. C., Cantero, J., Cao, Y., Capua, M., Cardarelli, R., Cardillo, F., Carducci, G., Carli, T., Carlino, G., Carlson, B. T., Carlson, E. M., Carminati, L., Carney, R. M. D., Caron, S., Carquin, E., Carra, S., Carratta, G., Carter, J. W. S., Carter, T. M., Casado, M. P., Casha, A. F., Castiglia, E. G., Castillo, F. L., Garcia, L. C., Gimenez, V. C., Castro, N. F., Catinaccio, A., Catmore, J. R., Cattai, A., Cavaliere, V., Cavasinni, V., Celebi, E., Celli, F., Cerny, K., Cerqueira, A. S., Cerri, A., Cerrito, L., Cerutti, F., Cervelli, A., Cetin, S. A., Chadi, Z., Chakraborty, D., Chan, J., Chan, W. S., Chan, W. Y., Chapman, J. D., Chargeishvili, B., Charlton, D. G., Charman, T. P., Chatterjee, M., Chau, C. C., Chekanov, S., Chekulaev, S. V., Chelkov, G. A., Chen, B., Chen, C., Chen, C. H., Chen, H., Chen, J., Chen, S., Chen, S. J., Chen, X., Chen, Y., Chen, Y. -H., Cheng, H. C., Cheng, H. J., Cheplakov, A., Cheremushkina, E., El Moursli, R. C., Cheu, E., Cheung, K., Chevalerias, T. J. A., Chevalier, L., Chiarella, V., Chiarelli, G., Chiodini, G., Chisholm, A. S., Chitan, A., Chiu, I., Chiu, Y. H., Chizhov, M. V., Choi, K., Chomont, A. R., Chou, Y., Chow, Y. S., Christopher, L. D., Chu, M. C., Chu, X., Chudoba, J., Chwastowski, J. J., Cieri, D., Ciesla, K. M., Cindro, V., Cioara, I. A., Ciocio, A., Cirotto, F., Citraro, S., Citron, Z. H., Citterio, M., Ciubotaru, D. A., Ciungu, B. M., Clark, A., Clark, P. J., Clawson, S. E., Clement, C., Clissa, L., Coadou, Y., Cobal, M., Coccaro, A., Cochran, J., de Sa, R. C. L., Cohen, H., Coimbra, A. E. C., Cole, B., Colijn, A. P., Collot, J., Muino, P. C., Connell, S. H., Connelly, I. A., Conventi, F., Cooper-Sarkar, A. M., Cormier, F., Corpe, L. D., Corradi, M., Corrigan, E. E., Corriveau, F., Costa, M. J., Costanza, F., Costanzo, D., Cowan, G., Cowley, J. W., Crane, J., Cranmer, K., Creager, R. A., Crepe-Renaudin, S., Crescioli, F., Cristinziani, M., Cristoforetti, M., Croft, V., Crone, G. J., Crosetti, G., Cueto, A., Donszelmann, T. C., Cui, H., Cukierman, A. R., Cunningham, W. R., Czekierda, S., Czodrowski, P., Czurylo, M. M., da Cunha Sargedas De Sousa, M. J., da Fonseca Pinto, J. V., da Via, C., Dabrowski, W., Dachs, F., Dado, T., Dahbi, S., Dai, T., Dallapiccola, C., Dam, M., D'Amen, G., D'Amico, V., Damp, J., Dandoy, J. R., Daneri, M. F., Danninger, M., Dao, V., Darbo, G., Dartsi, O., Dattagupta, A., D'Auria, S., David, C., Davidek, T., Davis, D. R., Dawson, I., De, K., de Asmundis, R., de Beurs, M., de Castro, S., de Groot, N., de Jesus Pardal Vicente, M., de Jong, P., de la Torre, H., de Maria, A., de Pedis, D., de Salvo, A., de Sanctis, U., de Santis, M., de Santo, A., de Vivie De Regie, J. B., Dedovich, D. V., Deiana, A. M., Del Peso, J., Delabat Diaz, Y., Delgove, D., Deliot, F., Delitzsch, C. M., della Pietra, M., della Volpe, D., Dell'Acqua, A., Dell'Asta, L., Delmastro, M., Delporte, C., Delsart, P. A., Demers, S., Demichev, M., Demontigny, G., Denisov, S. P., D'Eramo, L., Derendarz, D., Derkaoui, J. E., Derue, F., Dervan, P., Desch, K., Dette, K., Deutsch, C., Deviveiros, P. O., Di Bello, F. A., Di Ciaccio, A., Di Ciaccio, L., Di Donato, C., Di Girolamo, A., Di Gregorio, G., Di Luca, A., Di Micco, B., Di Nardo, R., Di Sipio, R., Diaconu, C., Dias, F. A., Do Vale, T. D., Diaz, M. A., Capriles, F. G. D., Dickinson, J., Didenko, M., Diehl, E. B., Dietrich, J., Cornell, S. D., Pardos, C. D., Dimitrievska, A., Ding, W., Dingfelder, J., Dittmeier, S. J., Dittus, F., Djama, F., Djobava, T., Djuvsland, J. I., Do Vale, M. A. B., Dobre, M., Dodsworth, D., Doglioni, C., Dolejsi, J., Dolezal, Z., Donadelli, M., Dong, B., Donini, J., D'Onofrio, A., D'Onofrio, M., Dopke, J., Doria, A., Dova, M. T., Doyle, A. T., Drake, G., Drechsler, E., Dreyer, E., Dreyer, T., Drobac, A. S., Du, D., du Pree, T. A., Duan, Y., Dubinin, F., Dubovsky, M., Dubreuil, A., Duchovni, E., Duckeck, G., Ducu, O. A., Duda, D., Dudarev, A., Dudder, A. C., D'Uffizi, M., Duflot, L., Duhrssen, M., Dulsen, C., Dumancic, M., Dumitriu, A. E., Dunford, M., Dungs, S., Duperrin, A., Yildiz, H. D., Duren, M., Durglishvili, A., Dutta, B., Duvnjak, D., Dyckes, G. I., Dyndal, M., Dysch, S., Dziedzic, B. S., Eggleston, M. G., Eifert, T., Eigen, G., Einsweiler, K., Ekelof, T., El Jarrari, H., Ellajosyula, V., Ellert, M., Ellinghaus, F., Elliot, A. A., Ellis, N., Elmsheuser, J., Elsing, M., Emeliyanov, D., Emerman, A., Enari, Y., Erdmann, J., Ereditato, A., Erland, P. A., Errenst, M., Escalier, M., Escobar, C., Pastor, O. E., Etzion, E., Evans, G., Evans, H., Evans, M. O., Ezhilov, A., Fabbri, F., Fabbri, L., Fabiani, V., Facini, G., Fakhrutdinov, R. M., Falciano, S., Falke, P. 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[0000-0003-2165-871X], Weirich, M. [0000-0002-5129-872X], Weiser, C. [0000-0002-6456-6834], Wells, P.S. [0000-0003-4999-896X], Wenaus, T. [0000-0002-8678-893X], Wendland, B. [0000-0003-1623-3899], Wengler, T. [0000-0002-4375-5265], Wenig, S. [0000-0002-4770-377X], Wermes, N. [0000-0001-9971-0077], Wessels, M. [0000-0002-8192-8999], Whalen, K. [0000-0002-9383-8763], Wharton, A.M. [0000-0002-9507-1869], White, A.S. [0000-0003-0714-1466], White, A. [0000-0001-8315-9778], White, M.J. [0000-0001-5474-4580], Whiteson, D. [0000-0002-2005-3113], Whitmore, B.W. [0000-0001-9130-6731], Wiedenmann, W. [0000-0003-3605-3633], Wiel, C. [0000-0003-1995-9185], Wielers, M. [0000-0001-9232-4827], Wiglesworth, C. [0000-0001-6219-8946], Wiik-Fuchs, L.A.M. [0000-0002-5035-8102], Wilkens, H.G. [0000-0002-8483-9502], Wilkins, L.J. [0000-0002-7092-3500], Williams, D.M. [0000-0002-5646-1856], Williams, S. [0000-0001-6174-401X], Willocq, S. [0000-0002-4120-1453], Windischhofer, P.J. [0000-0001-5038-1399], Wingerter-Seez, I. [0000-0001-9473-7836], Winkels, E. [0000-0003-0156-3801], Winklmeier, F. [0000-0001-8290-3200], Winter, B.T. [0000-0001-9606-7688], Wobisch, M. [0000-0002-0688-3380], Wolf, A. [0000-0002-4368-9202], Wölker, R. [0000-0002-7402-369X], Wolter, M.W. [0000-0001-9184-2921], Wolters, H. [0000-0002-9588-1773], Wong, V.W.S. [0000-0001-5975-8164], Wongel, A.F. [0000-0002-6620-6277], Woods, N.L. [0000-0002-8993-3063], Worm, S.D. [0000-0002-3865-4996], Wosiek, B.K. [0000-0003-4273-6334], Woźniak, K.W. [0000-0003-1171-0887], Wraight, K. [0000-0002-3298-4900], Wu, S.L. [0000-0001-5866-1504], Wu, X. [0000-0001-7655-389X], Wu, Y. [0000-0002-1528-4865], Wuerzinger, J. [0000-0002-4055-218X], Wyatt, T.R. [0000-0001-9690-2997], Wynne, B.M. [0000-0001-9895-4475], Xella, S. [0000-0002-0988-1655], Xiao, X. [0000-0002-1344-8723], Xie, X. [0000-0001-6473-7886], Xu, D. [0000-0001-6355-2767], Xu, H. [0000-0001-6110-2172], Xu, L. [0000-0001-8997-3199], Xu, R. [0000-0002-1928-1717], Xu, T. [0000-0002-0215-6151], Xu, W. [0000-0001-5661-1917], Xu, Y. [0000-0001-9563-4804], Xu, Z. [0000-0001-9571-3131], Xu, Z. [0000-0001-9602-4901], Yabsley, B. [0000-0002-2680-0474], Yacoob, S. [0000-0001-6977-3456], Yallup, D.P. [0000-0003-4716-5817], Yamaguchi, N. [0000-0002-6885-282X], Yamaguchi, Y. [0000-0002-3725-4800], Yamazaki, T. [0000-0003-0411-3590], Yamazaki, Y. [0000-0003-3710-6995], Yan, Z. [0000-0002-2483-4937], Yang, H.J. [0000-0001-7367-1380], Yang, H.T. [0000-0003-3554-7113], Yang, S. [0000-0002-0204-984X], Yang, T. [0000-0002-4996-1924], Yang, X. [0000-0002-1452-9824], Yang, X. [0000-0002-9201-0972], Yang, Y. [0000-0001-8524-1855], Yang, Z. [0000-0002-7374-2334], Yao, W-M. [0000-0002-3335-1988], Yap, Y.C. [0000-0001-8939-666X], Ye, H. [0000-0002-4886-9851], Ye, J. [0000-0001-9274-707X], Ye, S. [0000-0002-7864-4282], Yeletskikh, I. [0000-0003-0586-7052], Yexley, M.R. [0000-0002-1827-9201], Yin, P. [0000-0003-2174-807X], Yorita, K. [0000-0003-1988-8401], Yoshihara, K. [0000-0002-3656-2326], Young, C.J.S. [0000-0001-5858-6639], Young, C. [0000-0003-3268-3486], Yuan, R. [0000-0002-8452-0315], Yue, X. [0000-0001-6956-3205], Zaazoua, M. [0000-0002-4105-2988], Zabinski, B. [0000-0001-5626-0993], Zacharis, G. [0000-0002-3156-4453], Zaffaroni, E. [0000-0003-1714-9218], Zahreddine, J. [0000-0002-6932-2804], Zaitsev, A.M. [0000-0002-4961-8368], Zakareishvili, T. [0000-0001-7909-4772], Zakharchuk, N. [0000-0002-4963-8836], Zambito, S. [0000-0002-4499-2545], Zanzi, D. [0000-0002-1222-7937], Zeißner, S.V. [0000-0002-9037-2152], Zeitnitz, C. [0000-0003-2280-8636], Zemaityte, G. [0000-0001-6331-3272], Zeng, J.C. [0000-0002-2029-2659], Zenin, O. [0000-0002-5447-1989], Ženiš, T. [0000-0001-8265-6916], Zenz, S. [0000-0002-9720-1794], Zerradi, S. [0000-0001-9101-3226], Zerwas, D. [0000-0002-4198-3029], Zgubič, M. [0000-0002-5110-5959], Zhang, B. [0000-0002-9726-6707], Zhang, D.F. [0000-0001-7335-4983], Zhang, G. [0000-0002-5706-7180], Zhang, J. [0000-0002-9907-838X], Zhang, K. [0000-0002-9778-9209], Zhang, L. [0000-0002-9336-9338], Zhang, L. [0000-0001-5241-6559], Zhang, M. [0000-0001-8659-5727], Zhang, R. [0000-0002-8265-474X], Zhang, X. [0000-0003-4731-0754], Zhang, X. [0000-0003-4341-1603], Zhang, Y. [0000-0002-4554-2554], Zhang, Z. [0000-0002-7853-9079], Zhao, P. [0000-0003-0054-8749], Zhao, Y. [0000-0003-0494-6728], Zhao, Z. [0000-0001-6758-3974], Zhemchugov, A. [0000-0002-3360-4965], Zheng, Z. [0000-0002-8323-7753], Zhong, D. [0000-0001-9377-650X], Zhou, C. [0000-0001-5904-7258], Zhou, H. [0000-0002-7986-9045], Zhou, M. [0000-0001-7223-8403], Zhou, N. [0000-0002-1775-2511], Zhu, C.G. [0000-0001-8015-3901], Zhu, C. [0000-0002-5918-9050], Zhu, H.L. [0000-0001-8479-1345], Zhu, H. [0000-0001-8066-7048], Zhu, J. [0000-0002-5278-2855], Zhu, Y. [0000-0002-7306-1053], Zhuang, X. [0000-0003-0996-3279], Zhukov, K. [0000-0003-2468-9634], Zhulanov, V. [0000-0002-0306-9199], Zieminska, D. [0000-0002-6311-7420], Zimine, N.I. [0000-0003-0277-4870], Zimmermann, S. [0000-0002-1529-8925], Živković, L. [0000-0003-4236-8930], Zoccoli, A. [0000-0002-0993-6185], Zoch, K. [0000-0003-2138-6187], Zorbas, T.G. [0000-0003-2073-4901], Zou, R. [0000-0002-0542-1264], Zwalinski, L. [0000-0002-9397-2313], Apollo - University of Cambridge Repository, Współautorami artykułu są członkowie ATLAS Collaboration w liczbie 2890, Aloisio, Alberto, Alviggi, Mariagrazia, Canale, Vincenzo, Della Pietra, Massimo, Merola, Leonardo, Massarotti, Paolo, Conventi, Francesco, Rossi, Elvira, Carlino, Giampaolo, de Asmundis, Riccardo, Di Donato, Camilla, Doria, Alessandra, Iengo, Paolo, Izzo, Vincenzo, Perrella, Sabrina, Sekhniaidze, Givi, Cirotto, Francesco, Lavorgna, Marco, Giannini, Antonio, and Atlas, Collaboration
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Kjerne- og elementærpartikkelfysikk: 431 [VDP] ,Physics - Instrumentation and Detectors ,Computer science ,data acquisition ,Tracking (particle physics) ,01 natural sciences ,Online farms and online filtering ,High Energy Physics - Experiment ,Subatomär fysik ,High Energy Physics - Experiment (hep-ex) ,Data acquisition ,Software ,cluster finding ,Subatomic Physics ,[PHYS.HEXP]Physics [physics]/High Energy Physics - Experiment [hep-ex] ,hardware ,Calibration and fitting methods ,Cluster finding ,Modular electronics ,Pattern recognition ,Trigger concepts and systems (hardware and software) ,Detectors and Experimental Techniques ,Instrumentation ,Mathematical Physics ,FPGA ,Settore FIS/01 ,Large Hadron Collider ,Pattern recognition, cluster finding, calibration and fitting methods ,track data analysis ,Detector ,integrated circuit ,microstrip [semiconductor detector] ,Modular electronic ,Instrumentation and Detectors (physics.ins-det) ,calibration and fitting methods ,ATLAS ,medicine.anatomical_structure ,Nuclear and elementary particle physics: 431 [VDP] ,Pattern recognition (psychology) ,design [electronics] ,semiconductor detector: microstrip ,LHC ,Computer hardware ,performance ,Particle Physics - Experiment ,530 Physics ,FOS: Physical sciences ,LHC, ATLAS, High Energy Physics ,Accelerator Physics and Instrumentation ,programming ,Calibration and fitting method ,semiconductor detector: pixel ,Atlas (anatomy) ,0103 physical sciences ,medicine ,High Energy Physics ,ddc:610 ,[PHYS.PHYS.PHYS-INS-DET]Physics [physics]/Physics [physics]/Instrumentation and Detectors [physics.ins-det] ,010306 general physics ,Field-programmable gate array ,numerical calculations ,pixel [semiconductor detector] ,010308 nuclear & particles physics ,business.industry ,paper ,bibliography ,Acceleratorfysik och instrumentering ,trigger ,LHC, Particle Tracking, High-level Trigger ,Particle Tracking ,efficiency ,High-level Trigger ,data management ,business ,Hadron-hadron collisions ,electronics: design - Abstract
We thank CERN for the very successful operation of the LHC, as well as the support staff from our institutions without whom ATLAS could not be operated efficiently. We acknowledge the support of ANPCyT, Argentina; YerPhI, Armenia; ARC, Australia; BMWFW and FWF, Austria; ANAS, Azerba¼an; SSTC, Belarus; CNPq and FAPESP, Brazil; NSERC, NRC and CFI, Canada; CERN; ANID, Chile; CAS, MOST and NSFC, China; COLCIENCIAS, Colombia; MSMT CR, MPO CR and VSC CR, Czech Republic; DNRF and DNSRC, Denmark; IN2P3-CNRS and CEA-DRF/IRFU, France; SRNSFG, Georgia; BMBF, HGF and MPG, Germany; GSRT, Greece; RGC and Hong Kong SAR, China; ISF and Benoziyo Center, Israel; INFN, Italy; MEXT and JSPS, Japan; CNRST, Morocco; NWO, Netherlands; RCN, Norway; MNiSW and NCN, Poland; FCT, Portugal; MNE/IFA, Romania; JINR; MES of Russia and NRC KI, Russian Federation; MESTD, Serbia; MSSR, Slovakia; ARRS and MIZŠ, Slovenia; DST/NRF, South Africa; MICINN, Spain; SRC and Wallenberg Foundation, Sweden; SERI, SNSF and Cantons of Bern and Geneva, Switzerland; MOST, Taiwan; TAEK, Turkey; STFC, United Kingdom; DOE and NSF, United States of America. In addition, individual groups and members have received support from BCKDF, CANARIE, Compute Canada, CRC and IVADO, Canada; Be¼ing Municipal Science & Technology Commission, China; COST, ERC, ERDF, Horizon 2020 and Marie Skłodowska-Curie Actions, European Union; Investissements d’Avenir Labex, Investissements d’Avenir Idex and ANR, France; DFG and AvH Foundation, Germany; Herakleitos, Thales and Aristeia programmes co-financed by EU-ESF and the Greek NSRF, Greece; BSF-NSF and GIF, Israel; La Caixa Banking Foundation, CERCA Programme Generalitat de Catalunya and PROMETEO TEO and GenT Programmes Generalitat Valenciana, Spain; Göran Gustafssons Stiftelse, Sweden; The Royal Society and Leverhulme Trust, United Kingdom. The crucial computing support from all WLCG partners is acknowledged gratefully, in particular from CERN, the ATLAS Tier-1 facilities at TRIUMF (Canada), NDGF (Denmark, Norway, Sweden), CC-IN2P3 (France), KIT/GridKA (Germany), INFN-CNAF(Italy), NL-T1 (Netherlands), PIC (Spain), ASGC (Taiwan), RAL (U.K.) and BNL (U.S.A.), the Tier-2 facilities worldwide and large non-WLCG resource providers. Major contributors of computing resources are listed in ref. [52]., The ATLAS Fast TracKer (FTK) was designed to provide full tracking for the ATLAS high-level trigger by using pattern recognition based on Associative Memory (AM) chips and fitting in high-speed field programmable gate arrays. The tracks found by the FTK are based on inputs from all modules of the pixel and silicon microstrip trackers. The as-built FTK system and components are described, as is the online software used to control them while running in the ATLAS data acquisition system. Also described is the simulation of the FTK hardware and the optimization of the AM pattern banks. An optimization for long-lived particles with large impact parameter values is included. A test of the FTK system with the data playback facility that allowed the FTK to be commissioned during the shutdown between Run 2 and Run 3 of the LHC is reported. The resulting tracks from part of the FTK system covering a limited η-ϕ region of the detector are compared with the output from the FTK simulation. It is shown that FTK performance is in good agreement with the simulation., ANPCyT, Argentina, YerPhI, Armenia, ARC, Australia, BMWFW and FWF, Austria, ANAS, Azerbaijan, SSTC, Belarus, CNPq and FAPESP, Brazil, NSERC, NRC and CFI, Canada, CERN, ANID, Chile, CAS, MOST and NSFC, China, COLCIENCIAS, Colombia, MSMT CR, MPO CR and VSC CR, Czech Republic, DNRF and DNSRC, Denmark, IN2P3-CNRS and CEA-DRF/IRFU, France, SRNSFG, Georgia, BMBF, HGF and MPG, Germany, GSRT, Greece, RGC and Hong Kong SAR, China, ISF and Benoziyo Center, Israel, INFN, Italy, MEXT and JSPS, Japan, CNRST, Morocco, NWO, Netherlands, RCN, Norway, MNiSW and NCN, Poland, FCT, Portugal, MNE/IFA, Romania, JINR, MES of Russia and NRC KI, Russian Federation, MESTD, Serbia, MSSR, Slovakia, ARRS and MIZŠ, Slovenia, DST/NRF, South Africa, MICINN, Spain, SRC and Wallenberg Foundation, Sweden, SERI, SNSF and Cantons of Bern and Geneva, Switzerland, MOST, Taiwan, TAEK, Turkey, STFC, United Kingdom, DOE and NSF, United States of America, BCKDF, CANARIE, Compute Canada, CRC and IVADO, Canada, Bejiing Municipal Science & Technology Commission, China, COST, ERC, ERDF, Horizon 2020 and Marie Skłodowska-Curie Actions, European Union, Investissements d’Avenir Labex, Investissements d’Avenir Idex and ANR, France, DFG and AvH Foundation, Germany, Herakleitos, Thales and Aristeia programmes co-financed by EU-ESF and the Greek NSRF, Greece, BSF-NSF and GIF, Israel, La Caixa Banking Foundation, CERCA Programme Generalitat de Catalunya and PROMETEO and GenT Programmes Generalitat Valenciana, Spain, Göran Gustafssons Stiftelse, Sweden, The Royal Society and Leverhulme Trust, United Kingdom
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- 2021
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38. Assessing Staff Alignment in Technical
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LeBlanc, Jim and Kurth, Martin
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Collection development (Libraries) -- Evaluation ,Technical services (Libraries) -- Models ,Business ,Library and information science - Abstract
Technical services units have routinely kept detailed monthly and annual statistics to assess productivity and efficiency, especially regarding functions that are easily measured. However, with the evolution of library user behavior, libraries' strategic directions, and technical services' practices, these numbers have become less and less useful in revealing the value of this work. In this paper, the authors introduce a methodology and draft model with which technical services managers can better assess not only their unit's productivity and efficiency, but the extent to which its activities align with a library's strategic values and the behavior of its users., In a summary of a discussion that took place at the 2013 American Library Association Annual Conference, Winjum reported on concerns shared by many technical services managers regarding the challenge [...]
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- 2018
39. Performances of flax shive-based lightweight composites with rapid hardening
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Dubois, V., Leblanc, A., Carpentier, O., Alhaik, G., and Wirquin, E.
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Fiber reinforced composites -- Research -- Thermal properties -- Mechanical properties ,Business ,Construction and materials industries - Abstract
ABSTRACT This research work aims to develop a rapid hardening lightweight composite including flax shives, foaming agent and earthern materials. The results show a satisfying workability just after the mixing [...]
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- 2018
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40. Categorization as a Generative Tool for Design Ideation
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Tatjana Leblanc and Maxime Leblanc
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Visual Arts and Performing Arts ,Categorization ,business.industry ,Artificial intelligence ,Ideation ,Psychology ,computer.software_genre ,business ,computer ,Natural language processing ,Generative grammar ,Education - Published
- 2021
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41. A phase 1b study of intraperitoneal oncolytic viral immunotherapy in platinum-resistant or refractory ovarian cancer
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Sarfraz Ahmad, Robert W. Holloway, Madhavi Manyam, Amanda J. Stephens, Jessica A. Kennard, James E. Kendrick, and Jane LeBlanc
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medicine.medical_specialty ,Abdominal pain ,Organoplatinum Compounds ,Nausea ,medicine.medical_treatment ,Vaccinia virus ,Carcinoma, Ovarian Epithelial ,Gastroenterology ,Circulating tumor cell ,Internal medicine ,medicine ,Humans ,Infusions, Parenteral ,Virotherapy ,Adverse effect ,Aged ,Oncolytic Virotherapy ,Ovarian Neoplasms ,Dose-Response Relationship, Drug ,business.industry ,Obstetrics and Gynecology ,Immunotherapy ,Middle Aged ,Neoplastic Cells, Circulating ,medicine.disease ,Progression-Free Survival ,Oncolytic virus ,Oncolytic Viruses ,Oncology ,Drug Resistance, Neoplasm ,Female ,medicine.symptom ,Ovarian cancer ,business - Abstract
Objective Our objective was to assess safety and adverse events associated with intraperitoneal Olvi-Vec virotherapy in patients with platinum-resistant or refractory ovarian cancer (PRROC). Secondary objectives included objective response rate (ORR) per RECIST 1.1 and progression-free survival (PFS). Methods Olvi-Vec is a modified vaccinia virus that causes oncolysis and immune activation. An open-label phase 1b trial using a 3 + 3 dose escalation was conducted. Intraperitoneal Olvi-Vec was given as monotherapy in two consecutive daily doses. Translational analyses included anti-virus antibody levels, viral shedding, circulating tumor cells (CTCs) and T cells. Results Twelve patients (median age: 69 years, range: 45–77) with median 5 prior therapies (range: 2–10) and 2 prior platinum lines (range: 1–5) were enrolled. There were three dose level cohorts: 3 × 109 (n = 6), 1 × 1010 (n = 5), and 2.5 × 1010 (n = 1) plaque forming units (PFU)/day on two consecutive days. Treatment-related adverse events (TRAEs) included G1/G2 nausea (n = 6), fever (n = 6), abdominal distention (n = 5), and abdominal pain (n = 4). There were no Grade 4 TRAEs, no dose relationship to TRAEs, and no deaths attributed to Olvi-Vec. The ORR was 9% (1/11). Stable disease (SD) was 64% (7/11), and SD ≥15 weeks was 46% (5/11). Median PFS was 15.7 weeks (95%CI: 5.7–34.5), including extended PFS in four patients (23.2, 34.5, 59.4+ and 70.8 weeks). Three patients had extended overall survival (deceased 33.6 months, and alive with disease at 54 and 59 months). CTCs diminished in 6/8 (75%) baseline-positive patients. Immune activation was demonstrated from virus-enhanced tumor infiltration of CD8+ T-cells and activation of tumor-specific T-cells in peripheral blood. Conclusions Oncolytic viral therapy with intraperitoneal Olvi-Vec showed promising safety, clinical activities, and immune activation in patients with PRROC, warranting further clinical investigation.
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- 2021
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42. Expanded phenotype of primary ciliary dyskinesia related to <scp> DRC1 </scp> pathogenic variant with dysmorphisms and vascular anomalies
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Gabriel Girouard, Marcel Mallet, Samuel LeBlanc, Eric P Allain, and Mouna Ben Amor
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Whole genome sequencing ,Pathology ,medicine.medical_specialty ,Aberrant left subclavian artery ,business.industry ,Vascular ring ,Clinical manifestation ,medicine.disease ,Phenotype ,otorhinolaryngologic diseases ,Genetics ,medicine ,business ,Gene ,Genetics (clinical) ,Primary ciliary dyskinesia - Abstract
We present a case of a female diagnosed with primary ciliary dyskinesia (PCD) type 21 with non-previously reported extrapulmonary symptoms, including facial features and congenital vascular anomalies. Whole genome sequencing in our patient revealed a homozygous pathogenic variant in the DRC1 gene and no other notable structural nor punctual variants. This case demonstrates a unique clinical manifestation of PCD, which is possibly associated with the presence of a homozygous pathogenic DRC1 variant. Therefore, we suggest that analysis of DRC1 be considered with PCD type 21 when such features are present.
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- 2021
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43. Charcot's motor brain map and 19th-century neurosurgery
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Richard Leblanc
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medicine.medical_specialty ,Psychoanalysis ,business.industry ,Historiography ,General Medicine ,Brain mapping ,humanities ,Homunculus ,medicine.anatomical_structure ,Cortex (anatomy) ,Intracranial surgery ,medicine ,Neurosurgery ,business ,Motor cortex ,Intracranial mass - Abstract
Neurosurgery is predicated on the knowledge of the structure-function relationship of the brain. When the topic is broached in its historiography, it begins with Fritch and Hitzig's report on the localization of motor function in the cortex of the dog and skips rapidly to Wilder Penfield's homunculus. In that gap are found the origins of modern neurosurgery in 3 papers published by Jean-Martin Charcot and Albert Pitres between 1877 and 1879 in which they describe the somatotopic organization of the human motor cortex and draw the first human brain map. Their findings, obtained through the clinicopathological method, gave relevance to David Ferrier's observations in animals. Their work was extensively cited, and their illustrations reproduced by Ferrier in his landmark lecture to the Royal College of Physicians in 1878. It was known to William Macewen, who used localization to guide him in resecting intracranial mass lesions, and to William Osler and John Hughlings Jackson, who were early advocates of intracranial surgery. This paper describes Charcot and Pitres' discovery of the cortical origin of human voluntary movement and its somatotopic organization, and their influence on 19th-century intracranial surgery. It fills a gap in the historiography of cerebral localization and neurosurgery.
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- 2021
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44. Glial Fibrillary Acidic Protein Autoimmunity
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Daniela Molinier-Tiganas, Jonathan Biberon, Quentin Bodard, Véronique Rogemond, Anne Ruiz, Bastien Bouldoires, Celine Derollez, Philippe Diraison, Daniela Andriuta, Alberto Vogrig, Amelie Leblanc, Thomas De Broucker, Aditya Ambati, Philippe Kerschen, Géraldine Picard, Thierry Tchoumi, Eve Chanson, Anne-Laure Kaminsky, Irina Grigorashvili-Coin, Clementine Fort, Fanny Duval, Roxana Genet, Jérôme Honnorat, Kumaran Deiva, Sergio Muñiz-Castrillo, Mathilde Goudot, Bastien Joubert, François Sellal, Gabriel Mirebeau, Anais Dutray, Marion Philbert, Guillaume Rieul, Véronique Bourg, Erwan Morvan, Jonathan Ciron, Adrien Bigot, Romain Marignier, Roxana Ameli, Lucie Hopes, Jean Louis Devoize, Nahema Issa, Mickael Bonnan, Elena-Camelia Rusu, Laurent Kremer, Florence Rulquin, Alice Gravier Dumonceau, Marie Benaiteau, Centre de recherche en neurosciences de Lyon - Lyon Neuroscience Research Center (CRNL), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université Jean Monnet [Saint-Étienne] (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Département de Neuroradiologie [Centre Hospitalier Lyon Sud - HCL], Centre Hospitalier Lyon Sud [CHU - HCL] (CHLS), Hospices Civils de Lyon (HCL)-Hospices Civils de Lyon (HCL), Hospices Civils de Lyon (HCL), Institut NeuroMyoGène (INMG), Université de Lyon-Université de Lyon-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Institut du Cerveau et de la Moëlle Epinière = Brain and Spine Institute (ICM), Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Institut Mondor de Recherche Biomédicale (IMRB), Institut National de la Santé et de la Recherche Médicale (INSERM)-IFR10-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), Centre de Référence Maladie Rare 'Syndromes neurologiques Paranéoplasiques', Hospices Civils de Lyon (HCL)-Hopital Neurologique, CHU Toulouse [Toulouse], Institut Toulousain des Maladies Infectieuses et Inflammatoires (Infinity), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Service de neurologie [Le Kremlin Bicêtre], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Bicêtre, Institut de Recherche en Infectiologie de Montpellier (IRIM), Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Institut National de la Santé et de la Recherche Médicale (INSERM), Excitabilité nerveuse et thérapeutique (ENT), Hôpital Henri Mondor-EA 4391, Service de Physiologie Explorations Fonctionnelles-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), Hôpitaux Civils de Colmar, Centre Psychothérapique de Nancy [Laxou] (CPN), Centre Hospitalier Régional Universitaire de Tours (CHRU Tours), Groupe hospitalier Pellegrin, CHU Bordeaux [Bordeaux], Service de neurologie [CHRU Nancy], Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy), Centre Hospitalier Saint Jean de Perpignan, Centre Hospitalier d'Angoulême (CH Angoulême), Université des Antilles - UFR des sciences médicales Hyacinthe Bastaraud (UA UFR SM), Université des Antilles (UA), CHU Clermont-Ferrand, Service de Neurologie [Brest], Hôpital d'Instruction des Armées 'Clermont-Tonnerre' (HIA), Commissariat à l'énergie atomique et aux énergies alternatives - Laboratoire d'Electronique et de Technologie de l'Information (CEA-LETI), Direction de Recherche Technologique (CEA) (DRT (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Service de neurologie [Amiens], CHU Amiens-Picardie, Laboratoire de Neurosciences Fonctionnelles et Pathologies - UR UPJV 4559 (LNFP), Université de Picardie Jules Verne (UPJV), Université Grenoble Alpes - UFR Médecine (UGA UFRM), Université Grenoble Alpes [2016-2019] (UGA [2016-2019]), Hôpital Pasteur [Nice] (CHU), CHU de Saint-Brieuc, CHU Pau, Université de Lyon-Université de Lyon-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Institut du Cerveau = Paris Brain Institute (ICM), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Centre Hospitalier Universitaire de Toulouse (CHU Toulouse), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), CHU Strasbourg, Université Grenoble Alpes (UGA), and ANR-18-RHUS-0012,BETPSY,Biomarkers in autoimmune EncephaliTis and Paraneoplastic neurological SYndromes(2018)
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Adult ,Male ,Pathology ,medicine.medical_specialty ,[SDV.NEU.NB]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology ,Myelitis ,Autoimmunity ,Autoimmune Diseases ,Cohort Studies ,Autoimmune Diseases of the Nervous System ,Cerebrospinal fluid ,Glial Fibrillary Acidic Protein ,medicine ,Humans ,Child ,Autoantibodies ,Retrospective Studies ,biology ,Glial fibrillary acidic protein ,business.industry ,Autoantibody ,Meningoencephalitis ,medicine.disease ,Hyperintensity ,biology.protein ,[SDV.IMM]Life Sciences [q-bio]/Immunology ,Immunohistochemistry ,Neurology (clinical) ,Antibody ,business - Abstract
Background and ObjectivesTo report the clinical, biological, and imaging features and clinical course of a French cohort of patients with glial fibrillary acidic protein (GFAP) autoantibodies.MethodsWe retrospectively included all patients who tested positive for GFAP antibodies in the CSF by immunohistochemistry and confirmed by cell-based assay using cells expressing human GFAPα since 2017 from 2 French referral centers.ResultsWe identified 46 patients with GFAP antibodies. Median age at onset was 43 years, and 65% were men. Infectious prodromal symptoms were found in 82%. Other autoimmune diseases were found in 22% of patients, and coexisting neural autoantibodies in 11%. Tumors were present in 24%, and T-cell dysfunction in 23%. The most frequent presentation was subacute meningoencephalitis (85%), with cerebellar dysfunction in 57% of cases. Other clinical presentations included myelitis (30%) and visual (35%) and peripheral nervous system involvement (24%). MRI showed perivascular radial enhancement in 32%, periventricular T2 hyperintensity in 41%, brainstem involvement in 31%, leptomeningeal enhancement in 26%, and reversible splenial lesions in 4 cases. A total of 33 of 40 patients had a monophasic course, associated with a good outcome at last follow-up (Rankin Score ≤2: 89%), despite a severe clinical presentation. Adult and pediatric features are similar. Thirty-two patients were treated with immunotherapy. A total of 11/22 patients showed negative conversion of GFAP antibodies.DiscussionGFAP autoimmunity is mainly associated with acute/subacute meningoencephalomyelitis with prodromal symptoms, for which tumors and T-cell dysfunction are frequent triggers. The majority of patients followed a monophasic course with a good outcome.
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- 2021
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45. The 2020 CCS atrial fibrillation guidelines for pharmacists: Top 10 takeaways
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Kori Leblanc, Laurent Macle, Amanda Carroccia, Jenny MacGillivray, and Jason G. Andrade
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medicine.medical_specialty ,business.industry ,Internal medicine ,medicine ,Cardiology ,Pharmaceutical Science ,Atrial fibrillation ,Pharmacy ,medicine.disease ,business - Published
- 2021
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46. Bacteria in the genus Streptomyces are effective biological control agents for management of fungal plant pathogens: a meta-analysis
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Nicholas LeBlanc
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biology ,business.industry ,fungi ,Biological pest control ,food and beverages ,biology.organism_classification ,Streptomyces ,Biotechnology ,Fungicide ,Animal ecology ,Disease management (agriculture) ,Insect Science ,Fusarium oxysporum ,Organic farming ,business ,Agronomy and Crop Science ,Bacteria - Abstract
Plant diseases caused by fungal plant pathogens are a significant constraint on the global production of horticultural and agronomic crops. Synthetic chemical fungicides are an important tool for managing these diseases but have negative impacts on the environment and are incompatible with organic agriculture. Application of bacteria in the genus Streptomyces Waksman and Henrici 1943 (Approved Lists 1980) as biological control agents is an alternative disease management strategy that has reduced environmental impacts and is compatible with organic agriculture. The goal of this study was to conduct a meta-analysis to test if Streptomyces biological control agents reduce disease caused by fungal plant pathogens and identify factors that alter biological control efficacy of these bacteria. Data were compiled from 160 studies representing 44 publications that tested the effect of Streptomyces on diseases caused by fungal plant pathogens of agronomic and horticultural crops. Overall, Streptomyces biological control agents significantly reduced disease by 56% compared to negative control groups. Additional analyses showed Streptomyces reduced disease caused by soilborne pathogens marginally more than disease from foliar pathogens. Biological control efficacy increased under controlled environments and when Streptomyces bacteria were applied under high disease pressure. Among different fungal pathogens and hosts, Streptomyces were most effective at controlling the soilborne pathogen Fusarium oxysporum Schltdl. and diseases of Solanum lycopersicum L. These results confirm Streptomyces reduce disease caused by fungal plant pathogens and provide novel insight into ways biological control efficacy can be further optimized by considering the production environment and pathogen-host combinations.
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- 2021
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47. Profile of Daughters and Sisters of Women With Polycystic Ovary Syndrome: The Role of Proband’s Glucose Tolerance
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Sharon E. Oberfield, Ricardo Azziz, Svetlana Ten, Denis A. Magoffin, Soren Harnois-Leblanc, Ethel Codner, Christianne J. Lane, Jean-Patrice Baillargeon, Michael I. Goran, Maria Isabel Hernandez, Fernando Cassorla, David H Geller, Natasha I. Leibel, and Revi P. Mathew
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Proband ,medicine.medical_specialty ,Adolescent ,Endocrinology, Diabetes and Metabolism ,Clinical Biochemistry ,Context (language use) ,Biochemistry ,Nuclear Family ,Endocrinology ,Sex hormone-binding globulin ,Risk Factors ,Insulin-Secreting Cells ,Internal medicine ,Glucose Intolerance ,medicine ,Humans ,Insulin ,Glucose homeostasis ,First-degree relatives ,Child ,Online Only Articles ,Glucose tolerance test ,medicine.diagnostic_test ,biology ,business.industry ,Siblings ,Ovary ,Biochemistry (medical) ,Glucose Tolerance Test ,Polycystic ovary ,Cross-Sectional Studies ,Glucose ,Androgens ,biology.protein ,Female ,Insulin Resistance ,business ,Body mass index ,Polycystic Ovary Syndrome - Abstract
Context First-degree relatives of women with polycystic ovary syndrome (PCOS) present hormonal and metabolic alterations compared to girls unrelated to PCOS. It is unknown whether glucose intolerance in the PCOS proband confers a more severe metabolic predisposition on their first-degree relatives. Objective To determine whether glucose tolerance status in women with PCOS is associated with worsened glucose metabolism and sex hormone levels in their peripubertal daughters or sisters. Design Cross-sectional study. Setting Seven academic centers in North America, South America, and Europe. Patients Sixty-four pairs of women with PCOS and their daughters or younger sisters aged between 8 and 14 years were recruited. Twenty-five mothers or older sisters with PCOS were glucose intolerant (GI) and 39 were normal glucose tolerant (NGT). Main Outcome Measures Beta-cell function estimated by the insulin secretion-sensitivity index-2 (ISSI-2) during an oral glucose tolerance test and by the disposition index during a frequently sampled IV glucose tolerance test. Free testosterone and 17-hydroxyprogesterone (17-OHP) levels. Results Being related to a GI PCOS proband was associated with a lower ISSI-2 (P-value = 0.032) after adjusting for ethnicity, body mass index z-score, and pubertal stage. They also had higher free testosterone (P-value = 0.011) and 17-OHP levels compared to girls with an NGT proband, the latter becoming significant after adjusting for confounders (P-value = 0.040). Conclusions Compared to first-degree female relatives of women with PCOS and NGT, first-degree relatives of women with PCOS and GI display lower beta-cell function and hyperandrogenemia, putting them at higher risk of GI and PCOS development.
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- 2021
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48. Tumor suppressor function of WT1 in acute promyelocytic leukemia
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Timothy J. Ley, Vaishali Basu, Christopher A. Miller, Matthew J. Christopher, David H. Spencer, Eric J. Duncavage, Casey D.S. Katerndahl, Hayley R LeBlanc, Lukas D. Wartman, Margery Gang, Andrew J. Menssen, Tyler T Elmendorf, Sai Mukund Ramakrishnan, and Shamika Ketkar
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Acute promyelocytic leukemia ,law ,business.industry ,Cancer research ,medicine ,Suppressor ,Hematology ,medicine.disease ,business ,Function (biology) ,law.invention - Published
- 2021
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49. Do you mind if I record?: Perceptions and practice regarding patient requests to record clinic visits in oncology
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Yvonne Y. Lei, Nora Horick, Karen Donelan, Rachel B. Jimenez, Fay J. Hlubocky, Deborah Collyar, Jeffrey Peppercorn, Cindy B. Matsen, Michelle M. Mello, Thomas W. LeBlanc, Erica L. Mayer, and Andrew E. Johnson
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Oncologists ,Physician-Patient Relations ,Cancer Research ,medicine.medical_specialty ,Practice setting ,Legal liability ,business.industry ,Oncology clinic ,media_common.quotation_subject ,Medical Oncology ,Appropriate use ,Oncology ,Surveys and Questionnaires ,Family medicine ,Perception ,Ambulatory Care ,medicine ,Humans ,Treatment decision making ,business ,media_common - Abstract
BACKGROUND Audio recordings of oncology clinic discussions can help patients retain and understand information about their disease and treatment decisions. Access to this tool relies on acceptance of recordings by oncologists. This is the first study to evaluate experience and attitudes of oncologists toward patients recording clinic visits. METHODS Medical, radiation, and surgical oncologists from 5 US cancer centers and community affiliates were surveyed to evaluate clinicians' experience, beliefs, and practices regarding patient-initiated recordings. RESULTS Among 360 oncologists (69% response rate), virtually all (93%) have experienced patients seeking to record visits. Although 75% are comfortable with recording, 25% are uncomfortable and 56% report concerns ranging from less thorough discussions to legal liability. Most (85%) always agree when patients ask to record, but 15% never or selectively allow recording. Although 51% believe recording is positive for the patient-physician relationship, a sizable minority report that it can lead to less detailed conversations (28%) or avoidance of difficult topics, including prognosis (33%). Views did not vary based on subspecialty, practice setting, or geographic region, but older age and years in practice were associated with more positive views of recording. The majority of clinicians (72%) desire institutional policies to govern guidelines about recordings. CONCLUSIONS Most oncologists are comfortable with patient requests to record visits, but a sizable minority remain uncomfortable, and access to recording varies solely on physician preference. This difference in care delivery may benefit from institutional policies that promote access while addressing legitimate physician concerns over privacy and appropriate use of recordings.
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- 2021
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50. Update of the Blood Lead Reference Value — United States, 2021
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Erik R. Svendsen, Joseph G. Courtney, Mateusz P. Karwowski, Patrick N. Breysse, Paul Allwood, Robert L. Jones, Perri Zeitz Ruckart, Tanya Telfair LeBlanc, Po-Yung Cheng, and Wilma Jackson
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Male ,medicine.medical_specialty ,Health (social science) ,National Health and Nutrition Examination Survey ,Epidemiology ,Health, Toxicology and Mutagenesis ,Population ,Health Information Management ,Reference Values ,Environmental health ,Health care ,Medicine ,Humans ,Full Report ,education ,education.field_of_study ,medicine.diagnostic_test ,business.industry ,Public health ,Infant ,General Medicine ,Hazard ,Health equity ,United States ,Lead Poisoning ,Lead ,Child, Preschool ,Blood lead level ,Female ,Centers for Disease Control and Prevention, U.S ,business ,Medicaid - Abstract
The negative impact of lead exposure on young children and those who become pregnant is well documented but is not well known by those at highest risk from this hazard. Scientific evidence suggests that there is no known safe blood lead level (BLL), because even small amounts of lead can be harmful to a child's developing brain (1). In 2012, CDC introduced the population-based blood lead reference value (BLRV) to identify children exposed to more lead than most other children in the United States. The BLRV should be used as a guide to 1) help determine whether medical or environmental follow-up actions should be initiated for an individual child and 2) prioritize communities with the most need for primary prevention of exposure and evaluate the effectiveness of prevention efforts. The BLRV is based on the 97.5th percentile of the blood lead distribution in U.S. children aged 1-5 years from National Health and Nutrition Examination Survey (NHANES) data. NHANES is a complex, multistage survey designed to provide a nationally representative assessment of health and nutritional status of the noninstitutionalized civilian adult and child populations in the United States (2). The initial BLRV of 5 μg/dL, established in 2012, was based on data from the 2007-2008 and 2009-2010 NHANES cycles. Consistent with recommendations from a former advisory committee, this report updates CDC's BLRV in children to 3.5 μg/dL using NHANES data derived from the 2015-2016 and 2017-2018 cycles and provides helpful information to support adoption by state and local health departments, health care providers (HCPs), clinical laboratories, and others and serves as an opportunity to advance health equity and environmental justice related to preventable lead exposure. CDC recommends that public health and clinical professionals focus screening efforts on populations at high risk based on age of housing and sociodemographic risk factors. Public health and clinical professionals should collaborate to develop screening plans responsive to local conditions using local data. In the absence of such plans, universal BLL testing is recommended. In addition, jurisdictions should follow the Centers for Medicare & Medicaid Services requirement that all Medicaid-enrolled children be tested at ages 12 and 24 months or at age 24-72 months if they have not previously been screened (3).
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- 2021
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