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Keywords can express the main content of an article or a sentence. Keywords extraction is a critical issue in many Natural Language Processing (NLP) applications and can improve the performance of many NLP systems. The traditional methods of keywords extraction are based on machine learning or graph model. The performance of these methods is influenced by the feature selection and the manually defined rules. In recent years, with the emergence of deep learning technology, learning features automatically with the deep learning algorithm can improve the performance of many tasks. In this paper, we propose a deep neural network model for the task of keywords extraction. We make two extensions on the basis of traditional LSTM model. First, to better utilize both the historic and following contextual information of the given target word, we propose a target center-based LSTM model (TC-LSTM), which learns to encode the target word by considering its contextual information. Second, on the basis of TC-LSTM model, we apply the self-attention mechanism, which enables our model has an ability to focus on informative parts of the associated text. In addition, we also introduce a two-stage training method, which takes advantage of large-scale pseudo training data. Experimental results show the advantage of our method, our model beats all the baseline systems all across the board. And also, the two-stage training method is of great significance for improving the effectiveness of the model.

Background and PurposeThe appearance and aggravation of diarrhea-predominant irritable bowel syndrome (IBS-D) have proven to be closely related to psychosocial factors. We aimed to measure altered spontaneous brain activity and functional connectivity (FC) in patients with IBS-D using resting-state functional magnetic resonance imaging (RS-fMRI) and to analyze the relationship between these parameters and emotional symptoms.MethodsThirty-six adult IBS-D patients and thirty-six demographic-matched healthy controls (HCs) underwent RS-fMRI scans. After processing RS-fMRI data, the values of the amplitude of low-frequency fluctuation (ALFF) and regional homogeneity (ReHo) of the two groups were compared. The abnormal regions were selected as the regions of interest to compare whole-brain seed-based FC between the groups. The relationships between RS-fMRI data and mood and gastrointestinal symptoms were analyzed using correlation and mediation analyses.ResultsCompared with HCs, IBS-D patients showed increased ALFF in the right cerebellum posterior lobe, the right lingual gyrus/calcarine, the right postcentral gyrus, the right superior frontal gyrus (SFG), and middle frontal gyrus (MFG), with decreased ALFF in the right inferior parietal lobule, the right striatum, the right anterior cingulated cortex, the right insula, the right hippocampus, the right thalamus, the right midbrain, and the left precuneus. IBS-D patients showed increased ReHo in the bilateral lingual gyrus/calcarine, the bilateral SFG, the right MFG, and the right postcentral gyrus, with decreased ReHo in the orbital part of the left inferior frontal gyrus and the right supplementary motor area. Patients showed enhanced FC between the left precuneus and the bilateral orbitofrontal cortex (OFC). There was a positive correlation between increased ALFF values in the right midbrain and anxiety-depression symptoms in IBS-D patients, and the mediating effect of gastrointestinal symptoms indirectly caused this correlation.ConclusionIBS-D patients had dysregulated spontaneous activity and FC in regions related to pain regulation and emotional arousal involved in prefrontal–limbic–midbrain circuit and somatosensory processing. The development of mood disorders in IBS-D patients may be partly related to the dysfunction of components in the dopamine pathway (especially the midbrain, OFC) due to visceral pain.

Current therapeutic strategies for diabetic foot ulcer (DFU) have focused on developing topical healing agents, but few agents have controlled prospective data to support their effectiveness in promoting wound healing. We tested a stem cell mobilizing therapy for DFU using a combination of AMD3100 and low-dose FK506 (tacrolimus) (AF) in streptozocin-induced type 1 diabetic (T1DM) rats and type 2 diabetic Goto-Kakizaki (GK) rats that had developed peripheral artery disease and neuropathy. Here, we show that the time for healing back wounds in T1DM rats was reduced from 27 to 19 days, and the foot wound healing time was reduced from 25 to 20 days by treatment with AF (subcutaneously, every other day). Similarly, in GK rats treated with AF, the healing time on back wounds was reduced from 26 to 21 days. Further, this shortened healing time was accompanied by reduced scar and by regeneration of hair follicles. We found that AF therapy mobilized and recruited bone marrow–derived CD133+ and CD34+ endothelial progenitor cells and Ym1/2+ M2 macrophages into the wound sites, associated with enhanced capillary and hair follicle neogenesis. Moreover, AF therapy improved microcirculation in diabetic and neuropathic feet in GK rats. This study provides a novel systemic therapy for healing DFU.

Background . Lumbar disc herniation (LDH) is a common disease in spinal surgery which often causes acute radicular pain. However, LDH with buttock pain (BP) as the main clinical symptom is rare. Herein, we retrospectively evaluated the efficacy and safety of percutaneous transforaminal endoscopic discectomy (PTED) in the treatment of LDH with the buttock as the primary clinical symptom. Methods . Totally 12 patients have LDH (L4-5) with BP who underwent PTED from January 2019 to June 2020 were enrolled. All patients performed magnetic resonance imaging (MRI) and computed tomography (CT) preoperatively, 1 week postoperatively, and at follow-up. The pain relieve were evaluated by the Visual analog scale (VAS), the functional recovery was assessed by Oswestry disability index (ODI) and Roland-Morris questionnaire (RMQ). Parameters were evaluated preoperatively, immediately after surgery, 1 month, 3 months and 6 months after surgery, respectively. Moreover, the lumbar function was determined by modified MacNab criteria. Results . Pain relieve was found in 11 patients postoperatively. The VAS, ODI and RMQ scores were improved significantly at the latest follow up visit compared to preoperative (P

This article explores the value of wall F-FDG PET/Cr imaging in the diagnosis of thyroid cancer, studies its ability to distinguish benign and malignant thyroid lesions, and seeks ways to improve the accuracy of diagnosis. The normal control group selected 40 patients who came to our center for physical examination. In the normal control group, the average value of the standard uptake value of both sides of the thyroid was used as the SUV of the thyroid gland and the highest SUV value of the patient's lesion (SUV max) represented the SUV of the lesion. After injection of imaging agent 18F-FD1G, routine imaging was performed at 1h, time-lapse imaging was performed at 2.5 h, and the changes with conventional imaging were compared to infer the benign and malignant lesions. We used SPSS software to carry out statistical analysis, respectively, carrying out analysis of variance, paired t-test, independent sample t-test, and linear correlation analysis. In the thyroid cancer group, 87.5% of the delayed imaging SUV was higher than the conventional imaging SUV, while 83.33% of the benign disease group had a lower SUV than the conventional imaging SUV. 18F-FDG PET/CT imaging has higher sensitivity and specificity for the diagnosis of recurrence or metastasis in patients with Tg positive. However, it has lower sensitivity and specificity for the diagnosis of 131I-Dx-WBS negative DTC and 18F-FDG PET/CT. The specificity increases with the increase of serum Tg level. The above results confirm that 18F-FDG PET/CT imaging is of great significance for the diagnosis of recurrence or metastasis in patients; with PET/CT imaging, the results changed 16.13% of the Tg-positive and 131I-Dx-WBS negative DTC patients' later treatment decision. The decision-making and curative effect evaluation have certain value.

In order to overcome the problems of low guidance accuracy, poor autonomy and high experimental cost during the landing of UA V, a method of scene simulation and cooperative target detection in uav autonomous landing is proposed. In this method, QR code image with strong error correction ability is adopted as the cooperation target, Unreal Engine 4 (UE4) is used to build UA V landing simulation scene, and the UnrealCV plug-in is installed to enable UE4 to communicate with external programs. Finally, in the scene, the accuracy of yolov3 (You Only Look Once v3), a object detection algorithm based on deep learning adopted in this paper, to detect the cooperative target position on the runway is verified. The simulation results show that the algorithm can detect the landing target position with 100% accuracy and recall rate, ensuring the smooth completion of the whole landing process.

Visibility prediction has important application value in transportation, aviation, military, agriculture and other fields. Traditional visibility monitoring instruments have the disadvantages of complex operation, expensive price and low accuracy. At the same time, the existing visibility prediction methods based on video images also have the disadvantages of low accuracy. In this paper, a visibility prediction method in foggy weather based on deep learning is proposed. The proposed method uses target detection network YOLOv5 (YOU ONLY LOOK ONCE V5) to detect the ground landmarks in the video, then establishes a camera imaging model to calculate distance of the ground landmarks, and finally obtains the visibility value according to the distance of the farthest landmark that can be detected. In the proposed method, CIOU _Loss is selected as the loss function of YOLOv5 to improve the convergence speed and prediction accuracy. The experimental results show that thanks to yolov5's powerful and fast detection capabilities, after the training of 200 epoches, the proposed method can detect landmarks in foggy images with a 100% recall rate, which has the advantages of low cost and high accuracy.

The core part of a hybrid truss bridge is the connection joint which combines the concrete chord and steel truss-web members. To study the mechanical behavior and failure mode of steel&ndash, concrete connection joints in a hybrid truss bridge, static model tests were carried out on two connection joints with the scale of 1:3 under the horizontal load which was provided by a loading jack mounted on the vertical reaction wall. The specimen design, experimental setup and testing procedure were introduced. In the experiment, the displacement, strain level, concrete crack and experimental phenomena were factually recorded. Compared with the previous study results, the experimental results in this study demonstrated that the connection joints had the excellent bearing capacity and deformability. The minimum ultimate load and displacement of the two connection joints were 5200 kN and 59.01 mm, respectively. Moreover, the connection joints exhibited multiple failure modes, including the fracture of gusset plates, the slippage of high-strength bolts, the local buckling of compressive splice plates, the fracture of tensile splice plates and concrete cracking. Additionally, the strain distribution of the steel&ndash, concrete connection joints followed certain rules. It is expected that the findings from this paper may provide a reference for the design and construction of steel&ndash, concrete connection joints in hybrid truss bridges.

Transformers have been widely utilized in recent NLP studies. Unlike CNNs or RNNs, the vanilla Transformer is position-insensitive, and thus is incapable of capturing the structural priors between sequences of words. Existing studies commonly apply one single mask strategy on Transformers for incorporating structural priors while failing at modeling more abundant structural information of texts. In this paper, we aim at introducing multiple types of structural priors into Transformers, proposing the Multiple Structural Priors Guided Transformer (MS-Transformer) that transforms different structural priors into different attention heads by using a novel multi-mask based multi-head attention mechanism. In particular, we integrate two categories of structural priors, including the sequential order and the relative position of words. For the purpose of capturing the latent hierarchical structure of the texts, we extract these information not only from the word contexts but also from the dependency syntax trees. Experimental results on three tasks show that MS-Transformer achieves significant improvements against other strong baselines.

Chemical peeling is an efficient method for the treatment of pigment disorders. For freckles, medium-depth to deep peeling using a phenol solution is one of the most effective chemical peels, and modifications of facial skin can be observed up to 20 years after peeling. However, applying phenol to the skin may cause serious side effects. Phenol peeling has been rarely used in Asia due to its tendency to cause permanent pigmentary changes and hypertrophic scars. In total, 896 Chinese inpatients with facial freckles were enrolled in this study. The phenol formula was modified with crystalline phenol, dyclonine, camphor, anhydrous alcohol and glycerin and adjusted to a concentration of 73.6–90.0%. The entire peeling treatment was divided into two procedures performed separately on 2 days. All patients exhibited 26% or greater improvement, and 99.66% of patients exhibited 51% or greater improvement (good and excellent). Scarring and systemic complications were not observed in any patient. The modified phenol formula is very effective and safe for the treatment of facial freckles in Asian patients. This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266 .

// Yu Ling 1, * , Yeye Kuang 2, * , Lin-Lin Chen 1 , Wei-Feng Lao 1 , Yao-Ru Zhu 1 , Le-Qi Wang 1 and Da Wang 1 1 Department of Colorectal Surgery, Sir Run Run Shaw Hospital, Zhejiang University of Medicine, Hangzhou, Zhejiang 310016, People’s Republic of China 2 Biomedical Center, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310016, People’s Republic of China * These authors have contributed equally to this work Correspondence to: Da Wang, email: wangda1973@hotmail.com Keywords: RON, splicing variants, PTEN, PI3K/AKT pathway, colorectal cancer cell Received: January 06, 2017 Accepted: March 01, 2017 Published: March 27, 2017 ABSTRACT Abnormal expression of the Recepteur d’Origine Nantais (RON) receptor tyrosine kinase is accompanied by the generation of multiple splice or truncated variants, which mediate many critical cellular functions that contribute to tumor progression and metastasis. Here, we report a new RON splice variant in the human colorectal cancer (CRC) cell line HT29. This variant is a 165 kda protein generated by alternative pre-mRNA splicing that eliminates exon 2, causing an in-frame deletion of 63 amino acids in the extracellular domain of the RON β chain. The deleted transcript was a single chain expressed in the intracellular compartment. Although it lacked tyrosine phosphorylation activity, the RONΔ165 E2 variant could phosphorylate phosphatase and tensin homolog (PTEN), thereby activating the PI3K/AKT pathway. In addition, in vitro and in vivo experiments showed that the RONΔ165 E2 promoted cell migration and tumor growth. Finally, in an investigation of 67 clinical CRC samples, the variant was highly expressed in about 58% of the samples, and was positively correlated with the invasive depth of the tumor (P < 0.05). These results demonstrate that the novel RONΔ165 E2 variant promoted tumor progression while activating the PI3K/AKT pathway via PTEN phosphorylation.

Due to poor robustness, instability, and the heavy burden of use, the traditional myoelectric control method is still powerless in the face of the control of the dexterous prosthetic hand. To solve this problem, a new method (CVEEI), that combines computer vision, eye tracking, electromyogram (EMG) and IMU was proposed in this paper. Firstly, through gazing (eye-tracking) in front of the screen, the grasping pattern of the objects can be fed back to the prosthetic hand controller; Then, the prosthetic hand can be controlled to transport the object to the position expected, on collaboration of both EMG and IMU. In this process, the grasping pattern of all objects can be recognized by computer vision in real-time. Importantly, through comparing the traditional EMG control method (co-contraction to switch) in the transport experiment of the objects, the superiority of this new method in operating the dexterous prosthetic hand was further verified (fast > 1s/single object) in this paper.

Background: Food safety incidents have aroused widespread public health concern, causing food price risk. However, the causal paths remain largely unexplored in previous literature. This paper sets out to identify the relations of local and spatial spillovers of food safety incidents and public health concerns to food price risk in consumer markets within a setting with heterogeneous food safety risk levels. Methods: (i) Theoretically, unlike prior work, this paper decomposes food safety risks into food safety incidents (objective incident component) and public health concern (subjective concern component). This article develops a theoretical framework of causality to capture the underlying causal pathways motivated by the theories of limited attention and two-step flow of communication. (ii) Empirically, using avian influenza shocks in China&rsquo, s poultry markets as natural experiments, this paper differentiates between low- and high-risk food and incidents. The article adopts dynamic spatial panel models to analyze potential nonlinearity, moderation, and mediation in the spillover of food safety risk to food price risk for a long panel of 30 provinces covering the November 2007 to November 2017 period. Results: (i) Food safety incident alone only triggers high-risk food price risk, not low-risk food price risk. (ii) Public health concern amplifies nonlinear food price risk triggered by food safety incident. (iii) High-risk incident intensifies negative pressure of public health concern on food price risk. (iv) Food safety incident indirectly affects high-risk food price risk through public health concern. Conclusions: Using a setting with heterogeneous risk levels, this paper documents that (i) food safety incident itself does not necessarily determine food price risk, whereas it is actually public health concern that directly causes nonlinear food price risk, (ii) public health concern spillover to food price risk is negatively moderated by high-risk incident, and (iii) food safety incident spillover to high-risk food price risk is mediated by public health concern. The findings complement current research by (i) elucidating the diverse impacts of food safety incident and public health concern on food price risk, which are obscure in previous literature, and (ii) highlighting that heterogeneous food and incident risk levels matter for determining food price risk spillover.

Introduction: The lifetime incidence of foot ulcers has been estimated to be 19% to 34% among persons with diabetes. Diabetic wound healing(DWH) remains a challenge. Given the promising role of stem cells in wound healing, the current study proposed to improve DWH by mobilizing and recruiting bone marrow stem cells pharmacologically with combination of AMD3100 and low-dose FK506 (AF) in rats. Methods: T2 GK rats and STZ induced T1DM SD rats were used. To determine the role of bone marrow stem cells, bone marrow from GFP tg Lewis were transplanted into wt Lewis rats and T1 rats were induced by STZ injection at 2 months following bone marrow transplantation. Full-thickness wounds were created in the dorsal skin or in the foot skin at 6 weeks after STZ injection or GK rats at 4 month old. Wounded rats were divided into two experimental groups and received saline or a combination of AMD3100 (1mg/kg) and FK506 (0.1mg/kg) immediately after wounding and every 2 days until complete healing. Results: At the time of wounding, all animals developed peripheral artery disease and neuropathy. The back wound healing time was reduced from 27 to 19 days and the foot wound healing time was reduced from 25 to 20 days in T1DM rats treated with AF. Similarly, the back wound healing time was reduced from 26(S) to 21(AF) days in GK rats. Equally important, healing was accompanied by reduced scar and regeneration of hair follicles. Searching for the mechanisms, we found that AF therapy mobilized bone marrow stem cells to peripheral blood and recruited bone marrow-derived CD31+CD133+ endothelial progenitor cells, CD34+ stem cells and Ym1/2+ M2 macrophages into the wound sites and enhanced capillary and hair follicle neogenesis. Conclusion: Combination of AMD3100 and low-dose FK506 results in better and faster healing of diabetic wounds in rats with diabetic peripheral artery disease and neuropathy. Our findings offer a significant therapeutic approach to healing of DFU. Disclosure L. Qi: None. A.R. Ahmadi: None. J. Huang: None. Q. Lin: None. M. Chen: None. H. Kuwabara: None. K. Iwasaki: None. J. Burdick: None. Z. Sun: None.

Kidney transplantation offers increased survival rates and improved quality of life for patients with end-stage renal disease, as compared to any type of renal replacement therapy. Over the past few decades, the rat kidney transplantation model has been used to study the immunological phenomena of rejection and tolerance. This model has become an indispensable tool to test new immunomodulatory pharmaceuticals and regimens prior to proceeding with expensive preclinical large animal studies. This protocol provides a detailed overview of how to reliably perform orthotopic kidney transplantation in rats. This protocol includes three distinctive steps that increase the probability of success: perfusion of the donor kidney by flushing through the portal vein and the use of a cuff system to anastomose the renal veins and ureters, thereby decreasing cold and warm ischemia times. Using this technique, we have achieved survival rates beyond 6 months with normal serum creatinine in animals with syngeneic or tolerant kidney transplants. Depending on the aim of the study, this model can be modified by pre- or posttransplant treatments to study the acute, chronic, cellular, or antibody-mediated rejection. It is a reproducible, reliable, and cost-effective animal model to study different aspects of kidney transplantation.

Tm3+/Tb3+/Sm3+ tri-doped transparent borate glasses were successfully synthesized via melt quenching technique, and the optical and luminescent properties were characterized by photoluminescence excitation, photoluminescence spectra, absorption spectra, decay time and chromaticity coordinates. The energy transfer of Tm3+, Tb3+ → Sm3+ in Tm3+/Tb3+/Sm3+ co-doped glass samples was demonstrated. The chromaticity coordinate (x = 0.3339, y = 0.3241) and color correlate temperature (CCT = 5420.73 K) close to the standard white light (x = 0.3333, y = 0.3333 and CCT = 5454.12 K) could be achieved in 0.4Tm3+/1.0 Tb3+/0.8Sm3+ (mol %) tri-doped glass sample. It is expected that the investigated glasses may be a promising candidate for white-light-emitting diodes, luminescent materials and fluorescent display devices.

The most promising alternatives to heart transplantation are left ventricular assist devices and artificial hearts; however, their use has been limited by thrombotic complications. To reduce these, sintered titanium (Ti) surfaces were developed, but thrombosis still occurs in approximately 7.5% of patients. We have invented a rapid-seeding technology to minimize the risk of thrombosis by rapid endothelialization of sintered Ti with human cord blood-derived endothelial cells (hCB-ECs). Human cord blood-derived endothelial cells were seeded within minutes onto sintered Ti and exposed to thrombosis-prone low fluid flow shear stresses. The hCB-ECs adhered and formed a confluent endothelial monolayer on sintered Ti. The exposure of sintered Ti to 4.4 dynes/cm2 for 20 hr immediately after rapid seeding resulted in approximately 70% cell adherence. The cell adherence was not significantly increased by additional ex vivo static culture of rapid-seeded sintered Ti before flow exposure. In addition, adherent hCB-ECs remained functional on sintered Ti, as indicated by flow-induced increase in nitric oxide secretion and reduction in platelet adhesion. After 15 day ex vivo static culture, the adherent hCB-ECs remained metabolically active, expressed endothelial cell functional marker thrombomodulin, and reduced platelet adhesion. In conclusion, our results demonstrate the feasibility of rapid-seeding sintered Ti with blood-derived hCB-ECs to generate a living antithrombotic surface.

The glasses with chemical composition of 25Na2O:23CaO:6P2O5:44B2O3:2ZrO2: xEu2O3 for extra different Eu2O3 concentrations of x = 0.25, 0.5, 0.75, 1.0 and 1.25 mol% were synthesized by the conventional melt quenching technique. The glass structure, physical property, optical and luminescence characteristics of the synthesized glasses were characterized by FT-IR spectroscopy, X-ray powder diffraction and photoluminescence (PL) spectra, respectively. The results indicated that the density and molar volume of the glasses were found to increase with Eu2O3 concentration. The glasses were composed of [PO4], [BO3] and [BO4] basic structural units. Under 393 nm wavelength excitation, five luminescence bands were observed at 578 nm, 592 nm, 612 nm, 653 nm and 701 nm, which corresponds to 5D0 → 7FJ (J = 0, 1, 2, 3, 4) transitions. And the most intense red emission was found at 612 nm. Moreover, the color coordinate and color correlated temperatures (CCTs) changed with Eu2O3 contents. This work shows the potential application of europium-doped glass samples in UV converted white light-emitting diodes (WLEDs) and other optical devices.

The measurement of similarity between trajectories of vessels is one of the kernel problems that must be addressed to promote the development of maritime intelligent traffic system (ITS). In this study, a new model of trajectory similarity measurement was established to improve the data processing efficiency in dynamic application and to reflect actual sailing behaviors of vessels. In this model, a feature point detection algorithm was proposed to extract feature points, reduce data storage space and save computational resources. A new synthesized distance algorithm was also created to measure the similarity between trajectories by using the extracted feature points. An experiment was conducted to measure the similarity between the real trajectories of vessels. The growth of these trajectories required measurements to be conducted under different voyages. The results show that the similarity measurement between the vessel trajectories is efficient and correct. Comparison of the synthesized distance with the sailing behaviors of vessels proves that results are consistent with actual situations. The experiment results demonstrate the promising application of the proposed model in studying vessel traffic and in supplying reliable data for the development of maritime ITS.

Because the aviation aiming pod has special structure, it cans not install angle sensor to measure its optical axis turning angle. In order to solve this problem, a turning angle measuring method based on image technique is given in this paper. A test model based on P3P is designed and a fast calculating method is given. The application result indicates that the test range and the test precision are satisfied for the test requirements.

Adhesions are a very common complication in the abdominal surgery. Animal studies and human trials have evaluated strategies designed to reduce and prevent postsurgical adhesions but few have an evidence base that justifies routine use. A strategy to prevent adhesions effectively remains an urgent need. We studied a reproducible model of intra-peritoneal adhesion formation in rats using laparotomy with several peritoneal sutures to produce the adhesions. Here we show that entraining endogenous stem cells into injury sites using the combined effect of AMD3100 and low-dose FK-506 (AF) can reduce the adhesion score significantly and abolish peritoneal adhesions in 45% of animals in a rat model of severe postsurgical intra-abdominal adhesions, compared with saline controls. Searching for mechanisms, we found AF treatment dramatically increased SDF-1 expressing cells, HGF expressing Ym1+ M2 macrophages and CD133+ stem cells in the injury sites of peritoneal surface at day 5 post-operation. Our results demonstrate that medically induced recruitment of autologous stem cells using AF significantly reduced postsurgical intra-abdominal adhesions. These findings suggest a novel effective therapeutic approach to preventing adhesions in patients.

As a typical device widely used in electronics and information systems, the super-heterodyne receiver plays a key role in the whole system. This study proposes a method of fault diagnosis and health assessment for super-heterodyne receivers based on intrinsic time-scale decomposition (ITD)-singular value decomposition (SVD) and logistic regression (LR). First, a state observer based on radial basis function (RBF) neural network is designed to calculate the residual error between the actual and estimated signal outputs. Second, proper rotation components of the residual error are obtained by ITD. Then the singular values of the components are extracted by SVD to form feature vectors. Finally, a second RBF neural network is trained by the features to realize the classification of common fault modes, and the LR model is trained to estimate the health state of the super-heterodyne receiver. The feasibility and effectiveness of the proposed scheme are demonstrated by the results of simulation experiments.

Introduction Severe burns are often associated with high morbidity and unsatisfactory functional and esthetic outcomes. Over the last two decades, stem cells have generated great hopes for the treatment of numerous conditions including burns. The aim of this systematic review is to evaluate the role of stem cell therapy as a means to promote burn wound healing. Methods Comprehensive searches in major databases were carried out in March 2017 for articles on stem cell therapy in burn wound healing. In total 2103 articles were identified and screened on the basis of pre-determined inclusion and exclusion criteria. Results Fifteen experimental and two clinical studies were included in the review. The majority of studies reported significant improvement in macroscopic burn wound appearance as well as a trend toward improved microscopic appearance, after stem cell therapy. Other parameters evaluated, such as re-vascularization, collagen formation, level of pro- and anti-inflammatory mediators, apoptosis and cellular infiltrates, yielded heterogeneous results across studies. Conclusion Stem cell therapy appears to exert a positive effect in burn wound healing. There is, therefore, justification for continued efforts to evaluate the use of stem cells as an adjunct to first-line therapies in burns.

Paraphrasing is a critical issue in many Natural Language Processing (NLP) applications. The traditional Pivot-based methods of extracting paraphrases require a large-scale bilingual parallel corpus. The quality of the extracted paraphrases is affected by the quality of bilingual parallel corpora and word alignment. In this paper, we propose a method for Chinese paraphrases extraction. An online translation system is used to obtain the candidate paraphrases of a word. A deep neural network model combined with cosine similarity is exploited to filter the candidate results through computing the similarity of word vectors between a word and its candidate paraphrase. Experiments are conducted in two ways: (1) The random sampling is employed to manually verify the correctness of the paraphrases results. The effect has been significantly improved; (2) We design two Question Answering (QA) systems based on the NLPCC2016 Document Based Question Answering (DBQA) corpus. One uses the BM25 model to retrieve the candidate answer sentences, and another uses the Convolution Neural Network (CNN) model. Extracted paraphrases are quite effective in question reformulation, enhancing the MRR from 56.33% to 60.21% (BM25) and from 63.82% to 66.60% (CNN) with the questions of NLPCC 2016 DBQA corpus.

Background: Postsurgical adhesions are a very common complication causing various symptoms from pain to bowel obstruction. We have developed a stem cell mobilizing strategy that enables long-term liver and kidney allograft survival without sustained immunosuppression in animals using a combination of AMD3100 and low-dose FK506 (AF). Serendipitously we have noted a subjective decrease in adhesion formation in animals with AF combination treatment. The purpose of this study was to evaluate the effect of a new stem cell mobilizing strategy on preventing postsurgical adhesion formation in rats. Methods: Abdominal adhesions were induced by creating suture knots on the parietal peritoneum in Lewis rats. Animals were divided randomly into four experimental groups and received subcutaneous injections of saline, single drug or AF combination every other day for 10 days. On postoperative day 14, animals were euthanized and the severity of adhesions were evaluated and scored blindly by five individual surgeons. Results: Most animals treated with saline or single drug exhibited severe peritoneal adhesions around sites of suture knots. AF combination significantly reduced the formation of peritoneal adhesions, 64% animals (7/11) showed few or mild adhesion and no animal showed severe peritoneal adhesions. Searching for mechanisms, we found AF treatment dramatically increased SDF-1 expressing cells, HGF expressing Ym1 M2 macrophages and CD133 stem cells in the injury sites of peritoneal surface at day 5 post-operation. Conclusion: Pharmacological mobilization and recruitment of endogenous stem cells using AF combination significantly reduced postsurgical intra-abdominal adhesions in rats. These findings suggest a novel therapeutic approach to preventing postsurgical adhesions in patients undergoing abdominal or pelvic surgery. Funding Statement: This work was supported by a start-up fund from the surgical department at Johns Hopkins University. Declaration of Interests: None of the authors has a financial interest in any of the products, or drugs mentioned in this manuscript. Ethics Approval Statement: Animals were maintained in a pathogen-free facility of Johns Hopkins University School of Medicine and all animal experiments were performed in accordance with the United States National Institutes of Health (NIH) guidance. All animal protocols were reviewed and approved by the Johns Hopkins University Animal Care and Use Committee.

Rapid regeneration of the remnant liver is critical for preventing liver failure and promoting recovery after extensive liver resection. Numerous studies have demonstrated the involvement of bone marrow-derived stem cells in liver regeneration and the potential benefits of bone marrow stem cell therapy. To avoid the preparation of stem cells, we proposed in this study to mobilize endogenous bone marrow stem cells pharmacologically with a combination of AMD3100 (A), an antagonist of CXCR4 and low-dose FK506 (F). Here we show that AF combination therapy significantly increased lineage negative (Lin-) CD34+ and Lin-CD133+ stem cells in peripheral blood and enhanced recruitment of CD133+ cells into the remnant liver in a rat model of 85% partial hepatectomy. Recruiting CD133+ stem cells in the remnant liver was associated with increased proliferation of hepatic oval cells and paralleled the increased SDF-1, CXCR4 and HGF expression. Importantly, AF combination therapy increased the number of Ki67 positive hepatocytes and BrdU incorporation in the remnant liver and improved serum levels of albumin. Our results demonstrate that pharmacological mobilization of endogenous bone marrow stem cells with AF combination therapy can enhance endogenous stem cell mobilization to promote liver regeneration and improve liver function after extensive hepatectomy.

With the development of Internet of Things (IoT) technology and its vast applications in ship transportation systems, such as the Automatic Identification System (AIS), a large quantity of ship trajectory data have been recorded and stored. Nowadays ship transportation has also entered the age of big data, which can support IoT applications in Intelligent Transportation System (ITS), e.g. traffic monitoring, fleet management and traffic safety enhancement. However, the redundancy of ship trajectory data considerably reduces the effectiveness and efficiency of large scale traffic data storage, mining and visualization. Therefore, compression processing of the data becomes a very important issue for these applications. Because ship trajectory is a type of vector data, employing the vector data compression algorithms is an efficient way to solve the data redundancy problem. In this paper, the pseudo-code of five typical vector data compression algorithms for ship trajectory data compression is introduced. The performances of these algorithms were tested by the compression experiments of actual ship trajectories in the Qiongzhou Strait. The results show that ships’ speeds and rate of turns, the requirement of real time processing can affect the option of the most appropriate algorithm, and the algorithm selection in different applications is suggested. The results and conclusions lay the foundation for the future development of ship transportation intelligentization.

The precast roof truss of prestressed concrete square pile is a new self-balancing system composed of prestressed concrete square pile, strut and steel tension rod. Based on finite element analysis methods, the bending moment and deformation under most unfavorable design load was checked upon crack resistant bending moment to verify its engineering feasibility, the optimal prestressed value was analyzed to get the camber of the top chord beam, and the optimal tension method for bottom chord tension rod was determined. Compared with finite element analysis results, the full scale model test was carried out to further verify its engineering feasibility and some optimization recommendation was proposed. It suggests that the tension order of middle section before diagonal rod, initial prestressed value of 10t, and prestressed control method of monitoring camber at midspan is the most reasonable and optimal solution.

This paper divides the seismic performance of shear wall into five levels: integrity, slight damage, slight ~ moderate damage and serious damage which are defined based on material damage. And physical and mechanical description of shear walls in each performance level is given. The displacement angle is selected as the seismic performance index limit. The numerical analysis of 524 pieces of shear walls has been made to discuss the influence on seismic deformation index limits of component according to axial compression ratio, flexure shear ratio, the nominal shear stress level, the hoop characteristic value and the reinforcement ratio of longitudinal bars. With mathematical statistic method, the calculation formula for deformation index limits of components is obtained, which can be used as the basis in the performance-based seismic evaluation of shear wall structures.

This paper divided the seismic performance of RC Components into five levels: integrity, slight damage, slight ~ moderate damage and serious damage, which were defined based on material damage. Physical and mechanical description of RC components in each performance level was given, which can be used as the basis of performance-based evaluation of concrete components in microscopic model and the basis of research on deformation index limits in macro components.

In order to apply the performance-based seismic design, an engineer must first find out whether the column is expected to fail in shear before or after flexural yielding. According to column failure characteristics and failure mode of reinforced concrete column, the UW-PEER structure performance database was discussed and analyzed. In order to investigate the relevance of failure mode and factors such as longitudinal reinforcement ratio, transverse reinforcement ratio, hoop spacing to depth ratio, aspect ratio, shearing resistance demand to shear capacity ratio and axial load ratio, Fisher’s discriminant analysis (FDA) of the above factors was carried out. A discriminant function was developed to identify column failure mode. Results show that three factors, i.e., Vp/Vn, hoop spacing to depth ratio and aspect ratio have important influence on the failure mode. The failure mode has less to do with longitudinal reinforcement ratio, transverse reinforcement ratio and axial load ratio. Through using these three factors and the model proposed, over 85.6% of the original grouped cases were correctly classified. The value of coefficient of Vp/Vn is the largest, which means that discriminant equation is most sensitive to the shearing resistance demand to shear capacity ratio.

The feasibility of transformer fast reenergizing with neutral point ungrounded after the external fault being removed is analyzed in this paper. By calculating overvoltage and discriminating magnetizing inrush current, it analyzes four ways to restore power of transformer and chooses the optimal strategy which is safe and time-saving. The result shows that in the case of transformer neutral point ungrounded, closing the low-voltage circuit side breaker before the high-voltage, which can effectively limit over-voltage in a safe range. The second harmonic characteristic of magnetizing waveform may disappear, while the intermittent angle characteristics are still significant. With the help of the intermittent angle principle, transformer differential protection may not misuse. The average time for each customer interruption is reduced from 40 minutes to 10 minutes and saves an hour for engineer on the way back and forth. It will greatly improve power supply reliability.

An on-board automatic test system (ATS) based on CPCI bus was designed utilizing the application of computer, virtual instrument and database technology. In this paper, the test system architecture was introduced, the hardware structure explained and the software implementation expounded. Application of the prototype system on aerial fire control equipment for a series of fighters proved that proposed system is more powerful in functions, better in user interface and more convenient in operation compared with the traditional automatic test system.

Neuropathic pain is still a basic science and clinical challenge now, the neuronal sensitization and glial activation in the spinal cord (SC) level are more far-reaching for contributing to pain hypersensitivity following chronic constriction injury (CCI). Accumulating evidence indicates that astrocytes and microglia are activated in the spinal cord dorsal horn (SCDH) after CCI. Suppressor of cytokine signaling 1 (SOCS1) plays an important role in regulating of neuronal inflammation. Here, we investigated the role of SOCS1 in SC played in neuropathic pain. We find SOCS1 was persistently downregulated in the spinal neurons after CCI in mice. On the contrary, overexpression of SOCS1 in the SC reversed CCI-induced pain behavioral, activation of neurons, astrocytes, microglia, and the expression of proinflammatory cytokines including tumor necrosis factor α (TNF-α), interleukin 1β (IL-1β) and IL-6. Over all, these results demonstrate that downregulation of SOCS1 contributed to the development and maintenance of neuropathic pain via activating of neurons, astrocytes, microglia, and proinflammatory cytokines. SOCS1 may be developed into a potential target for treating neuropathic pain.

Guiyang is located in southwestern China, which is a famous tourism city, and is awarded the title of “the Summer Capital of China”. A study on heavy metals in Guiyang urban soils was conducted. The results showed that the concentrations of Cd, Cu, Ni, Pb and Zn in Guiyang urban soils are significantly higher than their background values and Cu, Zn and Pb in Guiyang soils are accumulated seriously. The distribution characteristics of heavy metals in 3 districts are described as follows: the level of heavy metals in soils follows the order of Nanming District>Yunyan District>Xiaohe District. The spatial distribution of metals in urban soils of Guiyang shows that the level of metals in the central and eastern parts of Guiyang is relatively high, and its characteristics are attributed to the influence of commercial activities, heavy traffic and industrial emission. Compared with some other cities in China, Guiyang is characterized by relatively high accumulation level of Cd, Cu, and Zn in its soils.

The temperature rise of generator components has a great impact on operation performance for large turbine generator. In this paper, applying the general FE calculation software-ANSYS, with a sequential electromagnetic-thermal field coupling calculation method, temperature calculation on phase lead connecting structures of 1100MW nuclear power turbine generator parallel rings is presented. The calculation results could offer a basic analysis to optimize the design of the generator.

Various analytical approaches to performance-based seismic design are in development. Based on the current Chinese seismic codes，elastic capacity calculation under frequent earthquake and ductile details of seismic design shall be performed for whether seismic design of new buildings or seismic evaluation of existing buildings to satisfy the seismic fortification criterion “no damage under frequent earthquake, repairable under fortification earthquake, no collapse under severe earthquake”. However, for some special buildings which dissatisfy with the requirements of current building codes, elastic capacity calculation under frequent earthquake is obviously not enough. In this paper, the advanced performance-based seismic theory is introduced to solve the problems of seismic evaluation and strengthening for existing reinforced concrete structures, in which story drift ratio and deformation of components are used as performance targets. By combining the features of Chinese seismic codes, a set of performance-based seismic design method is established for reinforced concrete structures. Different calculation methods relevant to different seismic fortification criterions are adopted in the proposed method, which solve the problems of seismic evaluation for reinforced concrete structures.

Due to the complicated material behavior during the earthquake, the precision of simulation mainly depends on the hysteresis model of concrete and reinforcement. ABAQUS has strong nonlinear analysis ability, but its damaged-plastic model for concrete does not support spatial beam element. Therefore, the uniaxial hysteresis model suitable for fiber mod- el of concrete was developed by using the interface UMAT in this paper. The fiber beam mod- el is suitable for global elastic-plastic analysis of frame which is subjected to the combined action of cyclic lateral and gravity loads. The model is verified by experiments and the results show that the fiber model developed by authors possesses better accuracy and time-saving compared with traditional finite element model using solid element. It can be used with high calculation efficiency to analyze frames subjected to cyclic loading due to earthquake.

China issued this stamp (Fig. 1) on April 22, 2005, to celebrate the 36th World Earth Day. As 1 of 4 basic policies of the People’s Republic of China, environmental protection policy plays a substantial role in keeping the environmental development sustainable. It was the first time that China issued a World Earth Day themed stamp. The stamp depicts two colorful hands holding up our very own planet, Mother Earth. It symbolizes the beautiful sunshine, signifying that the Earth belongs to all the people with different colors of skin. The concept conveyed to the world through this stamp