9 results on '"Laurent Dube"'
Search Results
2. The optimal aminoglycoside and its dosage for the treatment of severe Enterococcus faecalis infection. An experimental study in the rabbit endocarditis model
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Jocelyne Caillon, Denis Bugnon, Nathalie Asseray, Laurent Dube, Gilles Potel, and Cédric Jacqueline
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Microbiology (medical) ,Time Factors ,medicine.drug_class ,Antibiotics ,Drug Evaluation, Preclinical ,Pharmacology ,Drug Administration Schedule ,Enterococcus faecalis ,Microbiology ,Pharmacokinetics ,medicine ,Tobramycin ,Animals ,Netilmicin ,Amikacin ,Gram-Positive Bacterial Infections ,biology ,business.industry ,Aminoglycoside ,Endocarditis, Bacterial ,General Medicine ,biology.organism_classification ,Bacterial Load ,Anti-Bacterial Agents ,Disease Models, Animal ,Infectious Diseases ,Female ,Gentamicin ,Rabbits ,Gentamicins ,business ,medicine.drug - Abstract
Aminoglycosides are recommended for the treatment of Enterococcus faecalis infections, especially in severe and bacteremic infection. However, the optimal aminoglycoside or the optimal dosage remains uncertain. This study aimed to compare the activity of four aminoglycosides against E. faecalis (gentamicin, netilmicin, tobramycin, and amikacin) and two dosages of gentamicin. One clinical strain of E. faecalis was used to induce aortic endocarditis in the study rabbits. Each aminoglycoside was infused daily over 3 days with a computer-regulated flow simulating human pharmacokinetics of 15 mg/kg/day for amikacin, 6 mg/kg/day for netilmicin, and 3 mg/kg/day for gentamicin and tobramycin. Additionally, two dosages of gentamicin (simulating 3 or 6 mg/kg/day) were compared over 1 or 3 days of treatment. The in vivo efficacy was assessed according to the bacterial count in vegetations, in comparison with a control group. Of the four aminoglycosides tested, only gentamicin and netilmicin showed significant antibacterial efficacy after 3 days of treatment. After only 1 day of treatment, the high dosage of gentamicin (6 mg/kg/day) was more effective than the standard dosage (3 mg/kg/day). Among the tested aminoglycosides, gentamicin showed the best efficacy, with the best results after 24 h of treatment for the highest dosage.
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- 2012
3. Interest of low-dose hydrocortisone therapy during brain-dead organ donor resuscitation: the CORTICOME study
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Pierre-François Dequin, Michel Pinsard, Marc Pierrot, Nicolas Pichon, Laurence Escaravage, Philippe Vignon, Laurent Martin Lefevre, Laurent Dube, Samira Zitouni, Stéphanie Ragot, Fabrice Cook, Jean Paul Bleichner, Edgard Menguy, Paul-Michel Mertes, Ischémie Reperfusion en Transplantation d’Organes Mécanismes et Innovations Thérapeutiques ( IRTOMIT), Université de Poitiers-Institut National de la Santé et de la Recherche Médicale (INSERM), Immunologie antivirale systémique et cérébrale, Université Paris-Sud - Paris 11 (UP11)-IFR93-Institut National de la Santé et de la Recherche Médicale (INSERM), Défaillance Cardiovasculaire Aiguë et Chronique (DCAC), Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL), Service de Soins Intensifs [Pontchaillou], Hôpital Pontchaillou-CHU Pontchaillou [Rennes], Service de Soins Intensifs [CHU Caen], Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU)-CHU Caen, Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN)-Tumorothèque de Caen Basse-Normandie (TCBN), Service de Soins Intensifs [Mondor], Hôpital Henri Mondor, Service de Soins Critiques [Angers], Centre Hospitalier Universitaire d'Angers (CHU Angers), PRES Université Nantes Angers Le Mans (UNAM)-PRES Université Nantes Angers Le Mans (UNAM), Service de Soins Intensifs [Angers], Service de réanimation médicale [CHU Rouen], Hôpital Charles Nicolle [Rouen]-CHU Rouen, Normandie Université (NU)-Normandie Université (NU)-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU), Service de Soins Intensifs [Les Oudairies], Centre Hospitalier Départemental - Hôpital de La Roche-sur-Yon, Service d'Anésthésie Réanimation [CHU Clermont-Ferrand], CHU Estaing [Clermont-Ferrand], CHU Clermont-Ferrand-CHU Clermont-Ferrand, Service de Soins Critiques [Bretonneau], Centre Hospitalier Régional Universitaire de Tours (CHRU Tours)-Hôpital Bretonneau, Service d'Accompagnement et Soins Palliatifs [CHU Limoges], CHU Limoges, Centre d'Investigation Clinique de Limoges (CIC1435), CHU Limoges-Institut National de la Santé et de la Recherche Médicale (INSERM), This work was supported by a ' bourse de recherche clinique de l ' Association Ouest-Transplant (2009), CHU Pontchaillou [Rennes], Hôpital Charles Nicolle [Rouen], CHU Rouen, Normandie Université (NU)-Normandie Université (NU)-CHU Rouen, Centre Hospitalier Départemental - Hôpital de La Roche-sur-Yon (CHD Vendée), and Autard, Delphine
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Male ,Resuscitation ,Vasopressin ,medicine.medical_specialty ,Brain Death ,Tissue and Organ Procurement ,Hydrocortisone ,Vasopressins ,Hemodynamics ,[SDV.GEN] Life Sciences [q-bio]/Genetics ,Critical Care and Intensive Care Medicine ,Norepinephrine (medication) ,03 medical and health sciences ,0302 clinical medicine ,medicine ,Weaning ,Humans ,030212 general & internal medicine ,Prospective cohort study ,Nordefrin ,[SDV.GEN]Life Sciences [q-bio]/Genetics ,business.industry ,Research ,030208 emergency & critical care medicine ,Tissue Donors ,3. Good health ,Surgery ,Anesthesia ,Shock (circulatory) ,Female ,medicine.symptom ,business ,medicine.drug - Abstract
International audience; INTRODUCTION: Circulatory failure during brain death organ donor resuscitation is a problem that compromises recovery of organs. Combined administration of steroid, thyroxine and vasopressin has been proposed to optimize the management of brain deceased donors before recovery of organs. However the single administration of hydrocortisone has not been rigorously evaluated in any trial. METHODS: In this prospective multicenter cluster study, 259 subjects were included. Administration of low-dose steroids composed the steroid group (n = 102). RESULTS: Although there were more patients in the steroid group who received norepinephrine before brain death (80% vs. 66%: P = 0.03), mean dose of vasopressor administered after brain death was significantly lower than in the control group (1.18 ± 0.92 mg/H vs. 1.49 ± 1.29 mg/H: P = 0.03), duration of vasopressor support use was shorter (874 min vs. 1160 min: P
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- 2014
4. In vivo efficacy of continuous infusion versus intermittent dosing of ceftazidime alone or in combination with amikacin relative to human kinetic profiles in a Pseudomonas aeruginosa rabbit endocarditis model
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Philippe Le Conte, Denis Bugnon, Marie-Aline Robaux, Dominique Navas, Jocelyne Caillon, Laurent Dube, Gilles Potel, M. F. Kergueris, and D. Baron
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Microbiology (medical) ,medicine.drug_class ,Antibiotics ,Colony Count, Microbial ,Ceftazidime ,Microbial Sensitivity Tests ,Pharmacology ,Pharmacokinetics ,In vivo ,Infusion Procedure ,medicine ,Animals ,Humans ,Pharmacology (medical) ,Amikacin ,Antibacterial agent ,business.industry ,Aminoglycoside ,Endocarditis, Bacterial ,Anti-Bacterial Agents ,Cephalosporins ,Disease Models, Animal ,Kinetics ,Infectious Diseases ,Pseudomonas aeruginosa ,Immunology ,Female ,Rabbits ,business ,medicine.drug - Abstract
Ceftazidime and amikacin were administered in a Pseudomonas aeruginosa rabbit endocarditis model using computer-controlled intravenous (iv) infusion pumps to simulate human serum concentrations for the following regimens: continuous (constant rate) infusion of 4, 6 or 8 g of ceftazidime over 24 h or intermittent dosing of 2 g every 8 h either alone or in combination with amikacin (15 mg/kg once daily). The in vivo activities of these regimens were tested on four Pseudomonas aeruginosa strains. Animals were killed 24 h after the beginning of treatment. Efficacy was assessed by comparing the effects of the different groups on bacterial counts in vegetations for each strain tested. For a susceptible reference strain (ATCC 27853; MICs of ceftazidime and amikacin 1 and 2 mg/L, respectively), continuous infusion of 4 g alone or with amikacin was as effective as intermittent dosing with amikacin. For a clinical isolate producing an oxacillinase (MICs of ceftazidime and amikacin 8 and 32 mg/L, respectively), continuous infusion of 6 g was equivalent to intermittent dosing. For a clinical isolate producing a TEM-2 penicillinase (MIC of ceftazidime and amikacin 4 mg/L), continuous infusion of 6 g, but not intermittent dosing, had a significant in vivo effect. For a clinical isolate producing an inducible, chromosomally encoded cephalosporinase (MIC of ceftazidime and amikacin 8 and 4 mg/L, respectively), neither continuous infusion nor intermittent dosing proved effective. Determination of ceftazidime concentrations in vegetations showed that continuous infusion produced tissue concentrations at the infection site far greater than the MIC throughout the treatment. It is concluded that continuous infusion of the same total daily dose provides significant activity as compared with fractionated infusion. This study confirms that a concentration of 4-5 x MIC is a reasonable therapeutic target in most clinical settings of severe P. aeruginosa infection.
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- 2001
5. Ketamine: new uses for an old drug
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Laurent Dube, Franck Conreux, Hélène Turroques, and Jean-Claude Granry
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Drug ,medicine.medical_specialty ,business.industry ,media_common.quotation_subject ,Analgesic ,Anesthesiology and Pain Medicine ,Intensive care ,medicine ,Ketamine ,Intensive care medicine ,business ,media_common ,Paediatric anaesthesia ,medicine.drug - Abstract
Over the years, ketamine has found many applications in paediatric anaesthesiology. Recent insights into the mechanism of its central action, and the pharmacology of its isomers have led to a re-evaluation of this drug, expanding the range of indications in adults. The best examples of the uses of ketamine as an analgesic are: in brief diagnostic or therapeutic procedures, during the post-operative period in neonates and infants as well as in paediatric anaesthesia and intensive care.
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- 2000
6. In vivo efficacy of linezolid in combination with gentamicin for the treatment of experimental endocarditis due to methicillin-resistant Staphylococcus aureus
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Jocelyne Caillon, M. F. Kergueris, Virginie Le Mabecque, Nathalie Asseray, Gilles Potel, Laurent Dube, Cédric Jacqueline, Eric Batard, and Denis Bugnon
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Microbiology (medical) ,Staphylococcus aureus ,medicine.drug_class ,Antibiotics ,Microbial Sensitivity Tests ,medicine.disease_cause ,Microbiology ,chemistry.chemical_compound ,Methicillin ,Anti-Infective Agents ,Acetamides ,Drug Resistance, Bacterial ,Medicine ,Endocarditis ,Animals ,Pharmacology (medical) ,Oxazolidinones ,Antibacterial agent ,business.industry ,Aminoglycoside ,Linezolid ,General Medicine ,Endocarditis, Bacterial ,biochemical phenomena, metabolism, and nutrition ,bacterial infections and mycoses ,medicine.disease ,Methicillin-resistant Staphylococcus aureus ,Disease Models, Animal ,Infectious Diseases ,chemistry ,Gentamicin ,Drug Therapy, Combination ,Rabbits ,Gentamicins ,business ,medicine.drug - Abstract
Indifference or even antagonism has mainly been reported with combinations including linezolid. The presence of in vitro antagonism is not always correlated with in vivo failure. The purpose of this study was to evaluate the in vivo activity of linezolid combined with gentamicin using a methicillin-resistant Staphylococcus aureus (MRSA) endocarditis experimental model. A human-like pharmacokinetic simulation was used for linezolid and gentamicin to improve the extrapolation of the results to human therapy. Contrary to the antagonism previously described in vitro, linezolid combined with gentamicin exhibited bactericidal activity on the two strains with a decrease of at least 4log 10 cfu/g of vegetation compared with controls. These data suggest that linezolid plus gentamicin could be an appropriate combination for the treatment of severe MRSA infections.
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- 2004
7. Simulation of human gentamicin pharmacokinetics in an experimental Enterococcus faecalis endocarditis model
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Denis Bugnon, Jocelyne Caillon, Laurent Dube, Gilles Potel, Cédric Jacqueline, Jean-Claude Granry, M. F. Kergueris, and Christèle Gras-Le Guen
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medicine.drug_class ,Antibiotics ,Colony Count, Microbial ,Enterococcus faecalis ,Microbiology ,Pharmacokinetics ,hemic and lymphatic diseases ,medicine ,Endocarditis ,Animals ,Pharmacology (medical) ,Experimental Therapeutics ,Gram-Positive Bacterial Infections ,Antibacterial agent ,Pharmacology ,biology ,integumentary system ,business.industry ,Aminoglycoside ,Endocarditis, Bacterial ,respiratory system ,biology.organism_classification ,Streptococcaceae ,medicine.disease ,eye diseases ,Anti-Bacterial Agents ,Disease Models, Animal ,Infectious Diseases ,Area Under Curve ,Immunology ,Gentamicin ,Female ,Rabbits ,Gentamicins ,business ,medicine.drug ,Half-Life - Abstract
Significant differences between animal and human pharmacokinetics may be responsible for the conflicting results of experimental studies. This study determined the impact of human pharmacokinetic simulation (HPS) on gentamicin activity in an Enterococcus faecalis endocarditis model. The decrease in bacterial counts was greater with HPS than with a dose-equivalent regimen without HPS.
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- 2003
8. Transient ST segment elevation in right precordial leads induced by psychotropic drugs: relationship to the Brugada syndrome
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Laurent Dube, Pierre Asfar, Frederic Rouleau, Jean Marc Dupuis, Stephane Boulet, Jacques Victor, and Philippe Alquier
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Adult ,Male ,medicine.medical_specialty ,Time Factors ,Benign early repolarization ,Amitriptyline ,Bundle-Branch Block ,Precordial examination ,Antidepressive Agents, Tricyclic ,Electrocardiography ,Phenothiazines ,Physiology (medical) ,Internal medicine ,Fluoxetine ,medicine ,ST segment ,Humans ,Flecainide ,Brugada syndrome ,Proarrhythmia ,Psychotropic Drugs ,business.industry ,Heart ,Syndrome ,Middle Aged ,medicine.disease ,Elevation (emotion) ,Death, Sudden, Cardiac ,Anesthesia ,Cardiology ,Antidepressive Agents, Second-Generation ,Female ,Cardiology and Cardiovascular Medicine ,business ,medicine.drug ,Antipsychotic Agents - Abstract
Psychotropic Drugs and ST Segment Elevation. Transient ST segment elevation in right precordial leads with use of psychotropic drugs is reported in two cases of overdose and one case of therapeutic administration. Flecainide did not reproduce ST segment elevation. The relationship of these abnormalities to the Brugada syndrome and the electrophysiologic hypothesis are discussed.
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- 2001
9. A Test Circuit for Producing Different TRV Waveforms with Special Regard to their Initial Shape
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Vojislav Narancic and Laurent Dube
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Engineering ,Transient recovery voltage ,business.industry ,General Engineering ,Electrical engineering ,Energy Engineering and Power Technology ,Hardware_PERFORMANCEANDRELIABILITY ,Discrete circuit ,Circuit extraction ,Constant power circuit ,Breaking capacity ,Hardware_INTEGRATEDCIRCUITS ,Electronic engineering ,Fuse (electrical) ,Equivalent circuit ,Electrical and Electronic Engineering ,business ,Circuit breaker ,Hardware_LOGICDESIGN - Abstract
In order to test high voltage circuit breakers in high power stations, efforts are being made to create a test circuit that will produce the same conditions as in actual power systems. To simulate these conditions, resistors in series and in parallel with a capacitor have been interposed in the test circuit to represent the system encompassing the breaker. Recent studies have revealed that capacitance, near the circuit-breaker, can have considerable influence on the breaking capacity of these breakers. This paper is concerned with the influence of parallel capacitors on test circuits and gives the parameters for accurate control of the initial shape of the TRV.
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- 1972
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