29 results on '"Kei Miyoshi"'
Search Results
2. Effects of a Combined Task Training Program Using Square Stepping Nets on the Walking Speed of Healthy Elderly
- Author
-
Kei Miyoshi, Yoshiharu Yokokawa, Hitomi Nishizawa, Ichiro Kai, and Ryota Nishikawa
- Subjects
medicine.medical_specialty ,business.industry ,Physical Therapy, Sports Therapy and Rehabilitation ,Healthy elderly ,Task (project management) ,Preferred walking speed ,03 medical and health sciences ,0302 clinical medicine ,Physical medicine and rehabilitation ,030502 gerontology ,Square (unit) ,Medicine ,0305 other medical science ,Training program ,business ,030217 neurology & neurosurgery - Published
- 2017
3. Differences in Muscle Activities of Healthy Males in Bicycle Ergometer Exercise in the Supine and Sitting Positions
- Author
-
Masayoshi Ohira, Yutaka Kanno, Kei Miyoshi, and Ah-Cheng Goh
- Subjects
030506 rehabilitation ,medicine.medical_specialty ,Supine position ,business.industry ,030232 urology & nephrology ,Physical Therapy, Sports Therapy and Rehabilitation ,Sitting Positions ,03 medical and health sciences ,0302 clinical medicine ,Physical medicine and rehabilitation ,Physical therapy ,Medicine ,Bicycle ergometer ,0305 other medical science ,business - Published
- 2016
4. Surgical treatment of clinical N1 non-small cell lung cancer: Ongoing controversy over diagnosis and prognosis
- Author
-
Shuji Adachi, Kei Miyoshi, Morihito Okada, Takeshi Mimura, Koichiro Iwanaga, and Noriaki Tsubota
- Subjects
Adult ,Male ,Oncology ,medicine.medical_specialty ,Lung Neoplasms ,Adenocarcinoma ,Carcinoembryonic antigen ,Carcinoma, Non-Small-Cell Lung ,Internal medicine ,Biomarkers, Tumor ,medicine ,Carcinoma ,Adjuvant therapy ,Humans ,Lung cancer ,Survival rate ,Aged ,Neoplasm Staging ,Proportional Hazards Models ,Aged, 80 and over ,Squamous-cell carcinoma of the lung ,biology ,business.industry ,Cancer ,General Medicine ,Middle Aged ,Prognosis ,medicine.disease ,Carcinoembryonic Antigen ,Survival Rate ,Logistic Models ,Treatment Outcome ,Lymphatic Metastasis ,Carcinoma, Squamous Cell ,biology.protein ,Female ,Surgery ,business - Abstract
The preoperative assessment of nodal status in lung cancer is complicated and problematic for physicians and surgeons. Although many patients with clinical N1 (cN1) non-small cell lung cancer (NSCLC) are candidates for surgical treatment, these patients represent a heterogeneous subgroup with unpredictable survival. We conducted this study to evaluate the surgical results of cN1 disease and to attempt to clarify the delicate issues surrounding its diagnosis and prognosis. The subjects of this study were 187 consecutive patients with cN1 adenocarcinoma or squamous cell carcinoma of the lung, who underwent complete resection without induction therapy. Only 25% of the adenocarcinomas and 54% of the squamous cell carcinomas were correctly diagnosed as N1 disease preoperatively. Multiple logistic regression analyses revealed that adenocarcinoma (P = 0.0141) was a significant predictor of pN2. Multivariate analyses revealed that nodal metastasis (P < 0.0001), large tumor size (P = 0.0079), and high serum carcinoembryonic antigen value (P = 0.0096) were significantly poor prognostic factors in cN1 patients. It is difficult to diagnose nodal status in patients with cN1 disease, which requires various surgical procedures, including plasty, possibly with adjuvant therapy in a defined high-risk subgroup.
- Published
- 2010
5. High Efficacy of Disopyramide in the Management of Ventricular Fibrillation Storms in a Patient with Brugada Syndrome
- Author
-
Yuhei Shiga, Sunao Kodama, Shunichiro Sumi, Yoshio Yamanouchi, Seiyo Maruyama, Kei Miyoshi, Hidenori Urata, and Hideaki Tojou
- Subjects
medicine.medical_specialty ,business.industry ,medicine.medical_treatment ,General Medicine ,medicine.disease ,Implantable cardioverter-defibrillator ,Discontinuation ,Icd implantation ,Anesthesia ,Internal medicine ,Ventricular fibrillation ,medicine ,Cardiology ,In patient ,Cardiology and Cardiovascular Medicine ,business ,Disopyramide ,Brugada syndrome ,medicine.drug - Abstract
The patient was a 57-year-old man with Brugada syndrome, who had been implanted with a implantable cardioverter defibrillator (ICD). The frequency of ventricular fibrillation (VF) started to increase about 4 years after ICD implantation, occurring, at worst, six times in one night. Immediately after starting oral administration of disopyramide, VF stopped occurring. He then discontinued taking disopyramide, but immediately after the discontinuation VF started occurring again, so he restarted taking disopyramide. Thereafter, VF completely stopped occurring. Findings observed in our case suggest that disopyramide could be added in our arsenal of medications for treating arrhythmic storms in patient with Brugada syndrome. (PACE 2010; 33:e53–e56)
- Published
- 2010
6. Additive Antihypertensive and Antihypertrophic Effects of Long-Acting Ca Blockers in Uncontrolled Hypertensive Patients With Angiotensin-Receptor Blocker Based Treatment
- Author
-
Yukiko Inoue, Hidenori Urata, Hideaki Tojyo, Chie Ando, Yoshio Yamanouchi, Sunao Kodama, Shunichiro Sumi, Kei Miyoshi, Hideya Niimura, Yoshihiro Tsuchiya, Keisuke Okamura, and Hiroyuki Mihara
- Subjects
Male ,Angiotensin receptor ,Nifedipine ,Tetrazoles ,Pharmacology ,Essential hypertension ,Losartan ,medicine ,Humans ,Amlodipine ,Aged ,business.industry ,Biphenyl Compounds ,Antagonist ,General Medicine ,Middle Aged ,Calcium Channel Blockers ,medicine.disease ,Candesartan ,Blood pressure ,Hypertension ,Benzimidazoles ,Drug Therapy, Combination ,Female ,Cardiology and Cardiovascular Medicine ,business ,medicine.drug - Abstract
The aim of the present study was to examine the antihypertensive and antihypertrophic effects of combined treatment with a long-acting calcium antagonist on top of an angiotensin II receptor blocker (ARB) in uncontrolled hypertensive patients. Patients with essential hypertension and a blood pressure > 140/90 mmHg on ARB monotherapy (losartan 50 mg/day or candesartan 8 mg/day) were randomly assigned to a nifedipine controlled release (CR) group (n = 15) or amlodipine group (n = 11). A significant additional antihypertensive effect was noted from 1 month with nifedipine and 2 months with amlodipine. The average daily dose was 25 mg for nifedipine and 5 mg for amlodipine. The cardiothoracic ratio was significantly reduced in both groups after 3 months. Left ventricular wall thickness and left ventricular mass index also decreased. Metabolic parameters, hepatic function, and renal function did not change significantly. Additional treatment with a long-acting calcium antagonist achieved further blood pressure reduction as well as an antihypertrophic effect in the uncontrolled patients with prior ARB monotherapy.
- Published
- 2009
7. Effects of Multi-Joint Angle Changes on EMG Activity and Force of Lower Extremity Muscles during Maximum Isometric Leg Press Exercises
- Author
-
Tsugutake Sadoyama, Ryuya Yanagihashi, Kei Miyoshi, Masako Azegami, Masayoshi Ohira, and Katsushi Akahane
- Subjects
musculoskeletal diseases ,medicine.medical_specialty ,Supine position ,Multi joint ,business.industry ,Physical Therapy, Sports Therapy and Rehabilitation ,Isometric exercise ,Anatomy ,Knee Joint ,musculoskeletal system ,Biceps ,Trunk ,body regions ,Gastrocnemius muscle ,Physical medicine and rehabilitation ,Medicine ,Leg press ,business - Abstract
The objectives of this study were to identify the position where optimal leg muscle force occurs and to analyze the lower extremity muscle activity by comparing different hip and knee joint angle positions using a newly developed closed kinetic chain (CKC) leg press exercise device. Muscle force and electromyogram (EMG) measurements during maximum voluntary isometric leg presses (MVC-CKC) were performed on 6 healthy women in 6 different knee flexion angles (15°, 30°, 45°, 60°, 75°, 90°) and 2 different postures (supine and trunk upright posture). Results showed that the muscle force of MVC-CKC reached its peak at 60° knee flexion angle in both postures. Significant knee angle-dependent differences in EMG activity for both rectus femoris and gastrocnemius muscles were observed, while posture-dependent differences in EMG were found in biceps femoris. These particular joint-dependent EMG activities may be explained by the architectural characteristics of bi-articular muscles and muscle length-tension relationship theory. Co-activation of an antagonist muscle may appear with activation of the gastrocnemius muscle when the knee approaches full extension. Consequently, measurement of isometric CKC leg extension muscle force at 60° knee flexion angle in the trunk upright posture seems to be the optimal position.
- Published
- 2007
8. Selective Mediastinal Lymphadenectomy for Clinico-Surgical Stage I Non–Small Cell Lung Cancer
- Author
-
Noriaki Tsubota, Kei Miyoshi, Morihito Okada, Toshihiko Sakamoto, Tsuyoshi Yuki, and Takeshi Mimura
- Subjects
Adult ,Male ,Pulmonary and Respiratory Medicine ,medicine.medical_specialty ,Lung Neoplasms ,Time Factors ,medicine.medical_treatment ,Hilum (biology) ,Dissection (medical) ,Mediastinal Neoplasms ,Disease-Free Survival ,Carcinoma, Non-Small-Cell Lung ,medicine ,Carcinoma ,Humans ,Lung cancer ,Lymph node ,Aged ,Neoplasm Staging ,Retrospective Studies ,Aged, 80 and over ,Surgical team ,business.industry ,Mediastinum ,medicine.disease ,Surgery ,Treatment Outcome ,medicine.anatomical_structure ,Lymphatic Metastasis ,Lymph Node Excision ,Female ,Stents ,Lymphadenectomy ,Cardiology and Cardiovascular Medicine ,business ,Follow-Up Studies - Abstract
Background Improved radiologic imaging provides earlier detection of non–small cell lung cancer, but controversy exists regarding the need for complete lymph node dissection. This study was designed to evaluate the possibility of lesser mediastinal dissection for early-stage lung cancer. Methods Selective mediastinal dissection is defined as follows: Dissection of the upper mediastinum for upper-lobe tumors is performed but it is not needed for lower-lobe tumors with intact hilar and lower mediastinal nodes. Also, dissection of the lower mediastinum for an upper-lobe tumor is not routinely required when the nodes in the hilum and upper mediastinum are negative. From 1997 through 2002, 377 patients with clinico-surgical stage I non–small cell lung cancer underwent curative-intent surgery with selective dissection (group S). In addition, 358 patients with the same-stage disease who underwent complete lymphadenectomy by the same surgical team served as historic controls (group C). Results The characteristics of the two groups were well balanced. There was no significant difference in disease-free survival ( p = 0.376) or overall survival ( p = 0.060). Multivariate analysis showed that the dissection mode did not significantly influence either disease-free survival ( p = 0.636) or overall survival ( p = 0.119). The postoperative morbidity rates were 17.3% and 10.1% for group C and group S, respectively ( p = 0.005). One operative death occurred in each group (0.3%). The rates of distant metastasis and local recurrence were similar in the two groups. Conclusions Selective mediastinal dissection for clinico-surgical stage I non–small cell lung cancer proved to be as effective as complete dissection, and although large multicenter trials are warranted, it might be considered as an alternative for curative surgery in this era of minimally invasive surgery.
- Published
- 2006
9. Surgery for Local Recurrence After Complete Response Had Been Obtained by Chemoradiotherapy for Small Cell Lung Cancer
- Author
-
Noriaki Tsubota, Kei Miyoshi, Miyako Satouchi, and Morihito Okada
- Subjects
Pulmonary and Respiratory Medicine ,Oncology ,medicine.medical_specialty ,business.industry ,Internal medicine ,medicine ,Non small cell ,business ,Complete response ,Chemoradiotherapy - Published
- 2006
10. Hybrid Surgical Approach of Video-Assisted Minithoracotomy for Lung Cancer
- Author
-
Tsuyoshi Yuki, Kei Miyoshi, Noriaki Tsubota, Morihito Okada, Toshihiko Sakamoto, and Takeshi Mimura
- Subjects
Pulmonary and Respiratory Medicine ,Thorax ,medicine.medical_specialty ,business.industry ,medicine.medical_treatment ,Cardiogenic shock ,Respiratory disease ,Sleeve Lobectomy ,Video-Assisted Surgery ,Critical Care and Intensive Care Medicine ,medicine.disease ,Surgery ,Cardiothoracic surgery ,medicine ,Thoracotomy ,Cardiology and Cardiovascular Medicine ,business ,Lung cancer - Abstract
Study objectives Controversy regarding the most suitable surgical approach for treating malignancies of the lung is a matter of continuous discussions. “Complete” video-assisted thoracic surgery (VATS) that is performed using only the vision of a monitor is generally limited to lung resections of minimal difficulty. With the great interest in minimally invasive techniques for treating various pathologies, we have widely applied an integrated surgical approach that combines muscle-sparing minithoracotomy (incision, 4 to 10 cm) and video assistance using mainly direct visualization of the lung resection, which we have called hybrid VATS . The aim of this study is to evaluate the usefulness of hybrid VATS. Design Retrospective single-center study. Interventions From January 1998 to October 2004, 405 of 678 lobectomies (60%) and 165 of 226 segmentectomies (73%) were performed for primary lung cancer using hybrid VATS. Results Bronchoplasty was performed in 93 of the 678 patients (14%) who underwent lobectomy and in 11 of the 226 patients (5%) who underwent segmentectomy. Hybrid VATS was utilized in 33% of sleeve lobectomy procedures and in 27% of sleeve segmentectomy procedures. The mean (± SD) surgical time using hybrid VATS was 164 ± 48 min for lobectomy and 158 ± 35 min for segmentectomy, and the mean blood loss was 166 ± 120 and 109 ± 80 mL, respectively. There was one operative mortality (0.2%) secondary to cardiogenic shock. Postoperative complications developed in 11% of patients with p-stage IA disease after undergoing hybrid VATS, in contrast to 19% of patients after undergoing open thoracotomy. The prognosis of patients treated by hybrid VATS was equivalent to that obtained with open thoracotomy. Conclusions Minithoracotomy combined with video support that is performed predominantly via direct visualization is a secure, integrated, minimally invasive approach to performing major resection for lung cancer, including atypical procedures such as bronchoplasty. This hybrid VATS can be an acceptable and satisfactory option whenever the performance of complete VATS is considered to be challenging.
- Published
- 2005
11. Border between N1 and N2 stations in lung carcinoma: Lessons from lymph node metastatic patterns of lower lobe tumors
- Author
-
Noriaki Tsubota, Morihito Okada, Takeshi Mimura, Tsuyoshi Yuki, Kei Miyoshi, Toshihiko Sakamoto, and Hiroyuki Nitanda
- Subjects
Adult ,Male ,Pulmonary and Respiratory Medicine ,medicine.medical_specialty ,Lung Neoplasms ,Hilum (biology) ,Bronchi ,Adenocarcinoma ,Metastasis ,Carcinoma, Non-Small-Cell Lung ,medicine ,Carcinoma ,Humans ,Lung cancer ,Survival rate ,Lymph node ,Aged ,Neoplasm Staging ,Retrospective Studies ,Aged, 80 and over ,business.industry ,Mediastinum ,Middle Aged ,Prognosis ,medicine.disease ,Surgery ,Survival Rate ,medicine.anatomical_structure ,Lymphatic Metastasis ,Subcarinal ,Carcinoma, Squamous Cell ,Carcinoma, Large Cell ,Female ,Lymph Nodes ,Cardiology and Cardiovascular Medicine ,business ,Follow-Up Studies - Abstract
ObjectiveDistinction of lymph node stations is one of the most crucial topics still not entirely resolved by many lung cancer surgeons. The nodes around the junction of the hilum and mediastinum are key points at issue. We examined the spread pattern of lymph node metastases, investigated the prognosis according to the level of the involved nodes, and conclusively analyzed the border between N1 and N2 stations.MethodsWe reviewed the records of 604 consecutive patients who underwent complete resection for non-small cell lung carcinoma of the lower lobe.ResultsThere were 390 patients (64.6%) with N0 disease, 127 (21.0%) with N1, and 87 (14.4%) with N2. Whereas 11.3% of patients with right N2 disease had skip metastases limited to the subcarinal nodes, 32.6% of patients with left N2 disease had skip metastases, of which 64.2% had involvement of N2 station nodes, except the subcarinal ones. The overall 5-year survivals of patients with N0, N1, and N2 disease were 71.0%, 50.8%, and 16.7%, respectively (N0 vs N1 P = .0001, N1 vs N2, P < .0001). Although there were no significant differences in survival according to the side of the tumor among patients with N0 or N1 disease, patients with a left N2 tumor had a worse prognosis than those with a right N2 tumor (P = .0387). The overall 5-year survivals of patients with N0, intralobar N1, hilar N1, lower mediastinal N2, and upper mediastinal N2 disease were 71.0%, 60.1%, 38.8%, 24.8%, and 0%, respectively. Significant differences were observed between intralobar N1 and hilar N1 disease (P = .0489), hilar N1 and lower mediastinal N2 disease (P = .0158), and lower and upper mediastinal N2 disease (P = .0446). Also, the 5-year survivals of patients with involvement up to station 11, up to station 10, and up to station 7 were 41.4%, 37.9% and 37.7%, respectively (difference not significant).ConclusionsN1 and N2 diseases appeared as a combination of subgroups: intralobar N1 disease, hilar N1 disease, lower mediastinal N2 disease, and upper mediastinal N2 disease. Interestingly, the survivals of patients with involvement up to interlobar nodes (station 11), main bronchus nodes (station 10), and subcarinal nodes (station 7) were identical. These data constitute the basis for a larger investigation to develop a lymph node map in lung cancer.
- Published
- 2005
12. Effect of Ageing on Quadriceps Muscle Strength and on the Forward Shift of Center of Pressure during Sit-to-stand Movement from a Chair
- Author
-
Kei Miyoshi, Teiji Kimura, Iwao Yamamoto, Takayuki Fujiwara, Yoshiharu Yokokawa, Goh Ah Cheng, and Yoshiyuki Kondo
- Subjects
medicine.medical_specialty ,business.industry ,Sit to stand ,Physical Therapy, Sports Therapy and Rehabilitation ,Isometric exercise ,Knee Joint ,Knee extension ,Body sway ,Physical medicine and rehabilitation ,Center of pressure (terrestrial locomotion) ,Ageing ,Physical therapy ,Medicine ,business ,Quadriceps muscle strength - Abstract
The purpose of this study was to investigate the effect of ageing on body sway during sit-to-stand movement from a chair and on quadriceps muscle strength in the elderly population. A total of 275 community dwellers volunteered to participate in this study. All subjects signed an informed consent statement prior to participating in this study. They were required to be able to perform a sit-to-stand movement from a chair independently. The postural sway for the subjects during the sit-to-stand movement from the chair was measured using a stabilometer. The analog signals of the subjects' center of pressure in the anterior-posterior direction (%Y-axis) derived from the stabilometer were recorded. The maximum isometric muscle strength of knee extension was measured using an isometric dynamometer at 90 degrees flexion of the knee joint. Our results demonstrate that as age increased, lower extremity muscle strength decreased, and forward shift of the center of pressure also decreased. It is possible that the elderly subjects could not use their propelling power because of decreased lower extremity muscle strength. Therefore, the forward shift of the center of pressure of elderly subjects also decreased causing them difficulty in standing up from a chair. Therefore, we believe that we there is a need to educate elderly people about accurate sit-to-stand movement and the importance of lower extremity muscle strength exercise.
- Published
- 2005
13. Atrial septal defect in apical hypertrophic cardiomyopathy associated with coronary spasm
- Author
-
Sunao Kodama, Takeaki Ohta, Yoshio Yamanouchi, Keijiro Saku, Hiroyuki Mihara, Natsumi Morito, Kei Miyoshi, Tadayuki Hiroki, Masahiro Ogawa, Hidenori Urata, Kanta Fujimi, Shizuka Matsuo, and Eiji Yahiro
- Subjects
Heart septal defect ,medicine.medical_specialty ,business.industry ,medicine.drug_class ,Closure operation ,medicine.medical_treatment ,Cardiomyopathy ,Hypertrophic cardiomyopathy ,Calcium channel blocker ,medicine.disease ,stomatognathic diseases ,Heart failure ,Surgical patch ,Internal medicine ,cardiovascular system ,medicine ,Cardiology ,cardiovascular diseases ,Cardiology and Cardiovascular Medicine ,business ,Cardiac catheterization - Abstract
Apical hypertrophic cardiomyopathy (HCM) is a well-known myocardial disease, but the additional coexistence of an atrial septal defect (ASD) and coronary spasm is quite rare. We report here on a 62-year-old man suffering from congestive heart failure due to apical HCM complicated by coronary spasm and secundum-type ASD. The transthoracic, transesophageal echocardiography and cardiac catheterization were useful for diagnosing and evaluating of the patient's status. A calcium channel blocker was given to prevent coronary spasm, and a surgical patch closure operation was successfully performed. Afterwards, his symptoms were alleviated.
- Published
- 2004
14. Successful catheter ablation of ventricular tachycardia originating from the idiopathic saccular apical left ventricular aneurysm
- Author
-
Natsumi Morito, Masahiro Ogawa, Kanta Fujimi, Yoshio Yamanouchi, Hiroyuki Mihara, Eiji Yahiro, Keijiro Saku, Takeaki Ohta, Tadayuki Hiroki, Sunao Kodama, Hidenori Urata, and Kei Miyoshi
- Subjects
medicine.medical_specialty ,medicine.diagnostic_test ,business.industry ,Ventricular Tachyarrhythmias ,medicine.medical_treatment ,Wide QRS complex ,Heart Aneurysm ,Catheter ablation ,medicine.disease ,Ventricular tachycardia ,Aneurysm ,Left Ventricular Aneurysm ,Internal medicine ,cardiovascular system ,medicine ,Cardiology ,cardiovascular diseases ,Cardiology and Cardiovascular Medicine ,business ,Electrocardiography - Abstract
Left ventricular (LV) aneurysm has been recognized to frequently become a substrate of ventricular tachyarrhythmias. We report a case of a 66-year-old woman with symptomatic sustained monomorphic ventricular tachycardia (SMVT) originating from saccular apical LV aneurysm without definite underlying diseases. We performed catheter ablation using electroanatomical and conventional bipolar potential mapping. During SMVT, we found an area of fragmented potential -40 ms preceding the earliest wide QRS complex in the area of the apical LV aneurysm. Radiofrequency applications were delivered to this area. Since then, SMVT was no longer inducible by programmed electrical stimulation. The patient has remained free of VT recurrences during a subsequent 12-month follow-up period.
- Published
- 2004
15. FIVE CASES OF DIABETIC MASTOPATHY
- Author
-
Yoshiatsu Sagara, Yoshiaki Rai, Tetsuya Takahama, and Kei Miyoshi
- Subjects
medicine.medical_specialty ,business.industry ,Internal medicine ,medicine ,business ,Diabetic mastopathy ,Gastroenterology - Abstract
Diabetic mastopathyは長期罹患の糖尿病患者にみられる乳腺の良性疾患であるが,臨床所見や画像上,癌と類似しているため鑑別が困難である.今回われわれはdiabetic mastopathyの5例を経験したので,報告する.年齢は34-73歳, 1型糖尿病(IDDM)が2例, 2型糖尿病(NIDDM)が3例.インスリン使用は3例(IDDM 2例, NIDDM 1例)であった.触診所見では全例に腫瘤を認めるが,マンモグラフィーでは2例に腫瘤影を認め,その他の症例はdense breastで腫瘤は同定できなかった.乳腺超音波では辺縁不整,低エコーの腫瘤を認めた. Fine needle aspiration cytology (FNA)では全例細胞が少なく, core needle biopsyまたはopen biopsyではじめて本症の確定診断を得た.病理組織学的にはいずれも硝子化した厚い膠原線維の増生と乳管周囲のリンパ球浸潤を認め, diabetic mastopathyに一致する所見であった.
- Published
- 2004
16. Future view of safe, painless and curative video assisted thoracoscopic surgery for lung cancer
- Author
-
Hideya Onishi, Katsuya Nakamura, and Kei Miyoshi
- Subjects
Pulmonary and Respiratory Medicine ,medicine.medical_specialty ,Chemotherapy ,business.industry ,medicine.medical_treatment ,General surgery ,Postoperative pain ,Disease ,medicine.disease ,Computer Science Applications ,Surgery ,Extended surgery ,Cardiothoracic surgery ,Video-assisted thoracoscopic surgery ,medicine ,Stage (cooking) ,Lung cancer ,business - Abstract
Before video-assisted thoracoscopic surgery (VATS) became widespread, surgical curability was thought to be the most important issue concerning thoracic surgery; extended surgery was preferred, and postoperative pain did not appear to be a priority. Therefore, only few studies have so far focused on postoperative pain associated with VATS. Although surgical disease curability is important, postoperative pain is also an important issue for patients. Patients will choose to undergo surgery in the institute that can perform both curative and postoperatively painless surgery if possible. Lesser postoperative pain also leads to earlier ambulation and discharge, and could potentially allow earlier initiation of the next stage of therapy (including chemotherapy and radiation) due to faster patient recovery both mentally and physically; this may result in a better outcome.
- Published
- 2016
17. Effect of Ca channel blocker on heart rate variability and plasma norepinephrine level in patients with remote myocardial infraction: Comparison of nifedipine and amlodipine
- Author
-
Takayuki Furuki, Kazuo Moroe, Tadayuki Hiroki, Tetsushi Wakiyama, Ryuichiro Miyawaki, Kei Miyoshi, Yoshio Urabe, and Makiko Takao
- Subjects
medicine.medical_specialty ,business.industry ,medicine.disease ,Nifedipine ,Internal medicine ,Anesthesia ,Plasma norepinephrine level ,medicine ,Cardiology ,Heart rate variability ,In patient ,Myocardial infarction ,Amlodipine ,business ,Ca channel ,medicine.drug - Abstract
陳旧性心筋梗塞入院患者29例Holter心電図による, 心拍変動の時間領域解析と周波数領域解析の諸指標について, T/P比が相異なるOa拮抗薬, すなわち, T/P比が小さなニフェジピンとT/P比が大きなアムロジピンによる影響を血漿ノルエピネフリン値の変動と対比して検討した.周波数領域解析では, ニフェジピン投与後, LF/HFは急激に増大したが, アムロジピン投与では緩徐に増大した.さらに, 時間領域解析では, SDとSDANNはニフェジピン投与後, べースライン時より低下したのに対し, アムロジピン投与後, 逆に増大し, 投薬終了時点においては, 両群間に有意差が認められた.また, 血漿ノルエピネフリン値はニフエジピン投与後, 著明に増加したが, アムロジピン投与後はべースライン時との間に有意な変動は認められなかった.
- Published
- 1998
18. Contents, Vol. 88, 1997
- Author
-
George Opio, Tetsushi Wakiyama, Marianne Hartford, Tetsuro Sugiura, A. Sgreccia, Chia-Lun Chao, Björn W. Karlson, Massimo Accorinti, Kei Miyoshi, Ulf Näslund, Andreas Mügge, Avi Pinchas, A. Heusch, Maria Penco, Toshio lzuoka, Yoshio Ishida, Yoriko Shimotsu, Aram Smolinsky, Willem J Remme, Francesco Ciciarello, M. Bourgeois, Raffaele Casale, Roderick K King, Saul Schaefer, K. Bachmann, Milovan Bojić, Diederik C.A van Hoogenhuyze, K. Reynen, Staffan Westberg, Dirk Hausmann, Mario Luzi, NM Magid, Tadayuki Hiroki, Louis Bartels, Antonio Mammarella, Maria Haglid, Leon Lurje, Shy Livschitz, Sergio Morelli, Eliezer Klainman, C. Perrone, Avanindra Jain, Ryuichiro Miyawaki, Giovanni Antonini, Yoshio Urabe, Steen M. Jensen, Hirotoshi Morii, Fragola Pv, Martin van der Ent, Aleksandar N. Neskovic, Babeth Rabinowitz, Ezra A. Amsterdam, J. Quagebeur, Yung-Zu Tseng, Kwan-Lih Hsu, Jer-Min Lin, Johan Herlitz, Ming-Fong Chen, Elieser Kaplinsky, Paolo Pasqualetti, Juey-Jen Hwang, Yasunori Nakayama, Guido Valesini, Kei Tsumura, Yoshiaki Hirose, Nili Zafrir, Toshiji Iwasaka, Poon-Ung Chieng, Francesco Fedele, Gershon Fink, Dick A.C.M Kruijssen, H. Singer, Kenneth Caidahl, Kohei Hayashida, O.N. Krogmann, Shimon Spitzer, Toru Satoh, Paola Pivetti-Pezzi, Ela Dhanak, Pierre Chouraqui, Yasuo Takayama, Petar Otšević, Paolo Voci, Michelle B. Sholar, Kazuo Moroe, Sadahiko Uchimoto, David Horoszowsky, Ivo Amende, A. Paulus, Mitsuo Inada, Marco Ferro Luzzi, Armando Dagianti, Leonardo Calò, Antonio Vitarelli, Jane Yang, Tri Thuong Nguyen, Takayuki Furuki, Tsunehiko Nishimura, Yi-Lwun Ho, Matthias Sturm, Erwin Blessing, Aleksandar D. Popovic, Göran Johansson, Shuji Kitashiro, Yuan-Teh Lee, Por-Jau Huang, Hanno Krauss, Chau-Chung Wu, Sören Häggmark, Luigi Ferrante, Jeffrey S. Borer, Roberta Priori, Teruhiro Tamura, Kent B. Lewandrowski, Per Albertsson, and Arthur J. Siegel
- Subjects
Traditional medicine ,business.industry ,Medicine ,Pharmacology (medical) ,Cardiology and Cardiovascular Medicine ,business - Published
- 1997
19. Hyperinsulinemia in Patients with Spastic Angina Pectoris
- Author
-
Ryuichiro Miyawaki, Kazuo Moroe, Kei Miyoshi, Yoshio Urabe, Tadayuki Hiroki, Tetsushi Wakiyama, and Takayuki Furuki
- Subjects
Angina Pectoris, Variant ,Blood Glucose ,Male ,medicine.medical_specialty ,medicine.medical_treatment ,Coronary Artery Disease ,Coronary Angiography ,Body Mass Index ,Diagnosis, Differential ,Angina ,Impaired glucose tolerance ,Hyperinsulinism ,Internal medicine ,medicine ,Hyperinsulinemia ,Spastic ,Humans ,Insulin ,Pharmacology (medical) ,Angina, Unstable ,cardiovascular diseases ,Risk factor ,Triglycerides ,business.industry ,Cholesterol, HDL ,Glucose Tolerance Test ,Middle Aged ,medicine.disease ,Acetylcholine ,nervous system diseases ,Surgery ,Cholesterol ,Coronary vasospasm ,Cohort ,Cardiology ,Female ,Cardiology and Cardiovascular Medicine ,business - Abstract
We evaluated the association between coronary spasm and hyperinsulinemia (high immunoreactive insulin, IRI) in patients with angina pectoris. The study cohort comprised 30 patients with spastic angina pectoris, 30 patients with angina pectoris showing fixed-obstructive coronary sclerosis and 30 control subjects who were matched for body mass index, age and sex. A 75-gram oral glucose test was performed, and blood sugar and IRI were serially measured concomitant with serum total cholesterol, triglyceride and HDL cholesterol. The IRI level at 60 min, the peak IRI during the test, sigma IRI and sigma IRI/sigma blood sugar were significantly higher in the patients than in the controls. Total cholesterol and LDL cholesterol levels were significantly increased in patients showing fixed-obstructive coronary sclerosis compared to controls.
- Published
- 1997
20. VIO soft-coagulation system for major pulmonary resections: results in 68 patients with primary lung cancer
- Author
-
Kei Miyoshi, Akihiko Uchiyama, and Katsuya Nakamura
- Subjects
Pulmonary and Respiratory Medicine ,Male ,medicine.medical_specialty ,Lung Neoplasms ,Blood Loss, Surgical ,Postoperative Hemorrhage ,Japan ,Surgical oncology ,medicine ,Electrocoagulation ,Humans ,New device ,Lung cancer ,Pneumonectomy ,Aged ,Retrospective Studies ,Aged, 80 and over ,business.industry ,Retrospective cohort study ,General Medicine ,Equipment Design ,Middle Aged ,medicine.disease ,Surgery ,Cardiac surgery ,Treatment Outcome ,Cardiothoracic surgery ,Coagulation system ,Feasibility Studies ,Female ,Pulmonary resection ,Cardiology and Cardiovascular Medicine ,business - Abstract
The VIO soft-coagulation system is a new device for tissue coagulation in which the output voltage is automatically regulated. We evaluated the safety and efficacy of this system for major pulmonary resection of lung cancer.We used bipolar VIO soft-coagulation for major pulmonary resection in 68 patients with primary lung cancer using the following three surgical procedures: (1) coagulation of the tissues around lobar vessels and bronchus; (2) fissure dissection; (3) lymph node dissection. The dissection in those steps was performed with both bipolar VIO soft-coagulation forceps and scissors. Results were analyzed with special reference to intraoperative complications, blood loss, and postoperative morbidity. The data in this study (VIO group) were compared with those of 78 lung cancer patients who underwent surgery using conventional electrocautery (CE group).The operations in this series included 60 lobectomies, 1 bilobectomy, 1 pneumonectomy, and 6 segmentectomies. With the VIO soft-coagulation system, coagulation of tissues around the lobar pulmonary vessels without injury to the pulmonary vessels or bronchus was effective. The mean blood loss in the VIO group was 90.6 g (range 5-595 g), which was significantly lower than that in the CE group (mean 141.0 g, range 5-700 g) (P = 0.014). Postoperative morbidity rates in the VIO and the CE group were 11.7% and 17.9%, respectively.The VIO soft-coagulation system is safe and feasible for major pulmonary resections in patients with lung cancer.
- Published
- 2010
21. Beneficial effect of combination therapy comprising angiotensin II receptor blocker plus calcium channel blocker on plasma adiponectin levels
- Author
-
Sunao Kodama, Shunichiro Sumi, Chie Ando, Hideya Niimura, Yukiko Inoue, Yoshihiro Tsuchiya, Yoshisuke Nonaka, Hidenori Urata, Keisuke Okamura, Tatsuyuki Kakuma, Kei Miyoshi, and Yoshio Yamanouchi
- Subjects
Male ,medicine.medical_specialty ,Angiotensin receptor ,Dihydropyridines ,Combination therapy ,Physiology ,medicine.drug_class ,chemistry.chemical_element ,Calcium channel blocker ,Calcium ,Pharmacology ,Benzoates ,Cohort Studies ,Internal medicine ,Internal Medicine ,medicine ,Humans ,Telmisartan ,Aged ,Retrospective Studies ,Sex Characteristics ,Adiponectin ,business.industry ,Antagonist ,Age Factors ,General Medicine ,Middle Aged ,Calcium Channel Blockers ,Endocrinology ,Blood pressure ,chemistry ,Hypertension ,Benzimidazoles ,Drug Therapy, Combination ,Female ,business ,Angiotensin II Type 1 Receptor Blockers ,Azetidinecarboxylic Acid ,medicine.drug - Abstract
The study aim was to examine the effect of combination therapy comprising angiotensin receptor blocker plus calcium antagonist on post-treatment plasma adiponectin levels compared to pretreatment levels. There was a significant gender difference in the relationship between preadiponectin level and age. In the search for contributing factors for treatment-based changes in adiponectin levels, these effects of gender and age were considered in statistical analysis. The adiponectin level in the combination therapy group was further increased compared to that in each of the monotherapy groups, despite there being no significant difference in antihypertensive effect, indicating that the combined medication provided an effect beyond that of lowering blood pressure.
- Published
- 2010
22. Chemotherapeutic agents potentiate adenoviral gene therapy for pancreatic cancer
- Author
-
Kenoki Ohuchida, Manabu Onimaru, Masao Tanaka, Norihiro Sato, Takuya Egami, Kazuhiro Mizumoto, Kei Miyoshi, Hiroki Toma, and Kunio Matsumoto
- Subjects
Cancer Research ,Antimetabolites, Antineoplastic ,Pancreatic disease ,Genetic enhancement ,Genetic Vectors ,Antineoplastic Agents ,Mice, SCID ,medicine.disease_cause ,Kidney ,Adenoviridae ,Cell Line ,Mice ,Pancreatic cancer ,Cell Line, Tumor ,medicine ,Animals ,Humans ,Adenovirus infection ,Etoposide ,Cell Proliferation ,Cisplatin ,Dose-Response Relationship, Drug ,business.industry ,Hepatocyte Growth Factor ,Gene Transfer Techniques ,Cancer ,General Medicine ,Genetic Therapy ,medicine.disease ,beta-Galactosidase ,Antineoplastic Agents, Phytogenic ,Xenograft Model Antitumor Assays ,Recombinant Proteins ,Pancreatic Neoplasms ,Electroporation ,Oncology ,Immunology ,Cancer research ,Fluorouracil ,business ,medicine.drug - Abstract
Adenovirus-mediated gene therapy combined with chemotherapeutic agents is expected to represent a new approach for treating pancreatic cancer. However, there have been no reports of definitive effects of chemotherapeutic agents on adenovirus-mediated gene therapies. In the present study, we investigated the effects of chemotherapeutic agents on the transduction efficiency of an adenovirus-based gene therapy. Adenovirus (Ad-NK4) expressing NK4, which acts as a hepatocyte growth factor antagonist, was used as a representative gene therapy. Pancreatic cancer cells infected with Ad-NK4 were treated with chemotherapeutic agents (5-fluorouracil [5FU], cisplatin or etoposide), and the NK4 levels in their culture media were measured. To examine the effects of chemotherapeutic agents in vivo, Ad-NK4 was administered to subcutaneous tumors in mice after treatment with the agents, and the tumor NK4 levels were measured. The NK4 levels in culture media from cells treated with 5FU, cisplatin and etoposide were 5.2-fold (P = 0.026), 6-fold (P < 0.001) and 4.3-fold (P < 0.001) higher than those of untreated cells, respectively. The chemotherapeutic agents also increased Ad-NK4 uptake. The NK4 levels in tumors treated with 5FU, cisplatin and etoposide were 5.4-fold (P = 0.006), 11.8-fold (P < 0.001) and 4.9-fold (P = 0.017) higher than those in untreated tumors, respectively. The present findings suggest that chemotherapeutic agents significantly improve the efficiency of adenovirus-mediated gene transfer in pancreatic cancer. Furthermore, they will contribute to decreases in the adenovirus doses required for gene transfer, thereby controlling the side-effects of adenovirus infection in normal tissues.
- Published
- 2009
23. VENTRICULAR PACING THRESHOLDS FOLLOWING HIGH-ENERGY VENTRICULAR DEFIBRILLATION SHOCKS
- Author
-
Sunao Kodama, Yoshio Yamanouchi, Kei Miyoshi, Eiji Yahiro, Natsumi Morito, Hidenori Urata, and Takeaki Ohta
- Subjects
High energy ,medicine.medical_specialty ,business.industry ,Defibrillation ,Internal medicine ,medicine.medical_treatment ,medicine ,Cardiology ,Ventricular pacing ,business - Published
- 2005
24. CHRONIC ANGIOTENSION II RECEPTOR BLOCKER DOES NOT ALTER VENTRICULAR DEFIBRILLATION THRESHOLDS
- Author
-
Hidenori Urata, Sunao Kodama, Takeaki Ohta, Natsumi Morito, Yoshio Yamanouchi, Eiji Yahiro, and Kei Miyoshi
- Subjects
medicine.medical_specialty ,Defibrillation ,business.industry ,Anesthesia ,Internal medicine ,medicine.medical_treatment ,medicine ,Cardiology ,Receptor ,business - Published
- 2005
25. P-172 The Optimal AV Delay in Patients with Complete AV Block
- Author
-
Seiyo Maruyama, Yoshio Yamanouchi, Shunichirou Sumi, Kei Miyoshi, Hideaki Toujou, and Hidenori Urata
- Subjects
Community and Home Care ,medicine.medical_specialty ,Epidemiology ,business.industry ,Block (telecommunications) ,Internal medicine ,medicine ,Cardiology ,In patient ,Av delay ,Cardiology and Cardiovascular Medicine ,business - Published
- 2009
26. Combined photic and nonphotic electro-oculographic responses in the clinical evaluation of the retinal pigment epithelium
- Author
-
Yutaka Tazawa, Kei Miyoshi, Michael F. Marmor, and Toshiro Mori
- Subjects
Adult ,Male ,medicine.medical_specialty ,Adolescent ,Eye disease ,Dark Adaptation ,Physiology (medical) ,Ophthalmology ,Retinitis pigmentosa ,medicine ,Humans ,Pigment Epithelium of Eye ,Retinal pigment epithelium ,Diabetic Retinopathy ,medicine.diagnostic_test ,business.industry ,Diabetic retinopathy ,Electrooculography ,Middle Aged ,medicine.disease ,Sensory Systems ,Electrophysiology ,medicine.anatomical_structure ,Female ,business ,Acetazolamide ,Clinical evaluation ,Photic Stimulation ,Retinitis Pigmentosa ,Retinopathy ,medicine.drug - Abstract
In an attempt to simplify the recording technique in electrophysiologic evaluation of the retinal pigment epithelium, we combined the electro-oculographic light rise, hyperosmolarity and acetazolamide responses in a single recording session. Recordings were performed in six normal subjects and in seven patients with diabetic retinopathy or retinitis pigmentosa. In the patients with background diabetic retinopathy, the hyperosmolarity responses were slightly reduced, while the acetazolamide response and the light rise was normal. In the patients with proliferative diabetic retinopathy, the hyperosmolarity response and light rise were remarkably reduced, while the acetazolamide response was normal. In the patients with retinitis pigmentosa, the hyperosmolarity response and light rise were decreased, while the acetazolamide response was normal. Despite a small study population, we concluded that the clinical results from our combined recording protocol were essentially the same as those reported for each response separately. Because this recording technique simplifies electrophysiologic evaluation of the retinal pigment epithelium, it may help clarify the mechanisms or localization of retinochoroidal and pigment epithelial diseases.
- Published
- 1991
27. Subject Index Vol. 88,1997
- Author
-
Marianne Hartford, Elieser Kaplinsky, C. Perrone, A. Sgreccia, Armando Dagianti, Leonardo Calò, Raffaele Casale, Antonio Vitarelli, Andreas Mügge, Tetsuro Sugiura, Yasunori Nakayama, George Opio, Jer-Min Lin, Aram Smolinsky, Ulf Näslund, Diederik C.A van Hoogenhuyze, Dick A.C.M Kruijssen, H. Singer, Yoshio Ishida, K. Reynen, Babeth Rabinowitz, Poon-Ung Chieng, Eliezer Klainman, Maria Penco, Ryuichiro Miyawaki, Giovanni Antonini, M. Bourgeois, Kazuo Moroe, Avi Pinchas, David Horoszowsky, Paolo Voci, Toru Satoh, Massimo Accorinti, Björn W. Karlson, Willem J Remme, Gershon Fink, A. Heusch, Roderick K King, Pierre Chouraqui, Yasuo Takayama, Yoriko Shimotsu, Petar Otšević, K. Bachmann, Hirotoshi Morii, Sergio Morelli, Steen M. Jensen, Kohei Hayashida, Shy Livschitz, Dirk Hausmann, Louis Bartels, Toshio lzuoka, Yoshiaki Hirose, Francesco Fedele, Kwan-Lih Hsu, Antonio Mammarella, Yoshio Urabe, Kent B. Lewandrowski, Martin van der Ent, Chau-Chung Wu, Milovan Bojić, Yung-Zu Tseng, Jeffrey S. Borer, Roberta Priori, Shimon Spitzer, Paolo Pasqualetti, Juey-Jen Hwang, Chia-Lun Chao, Mitsuo Inada, Kei Tsumura, Sören Häggmark, J. Quagebeur, Sadahiko Uchimoto, Mario Luzi, NM Magid, Luigi Ferrante, Saul Schaefer, Ming-Fong Chen, Guido Valesini, Johan Herlitz, Staffan Westberg, Tetsushi Wakiyama, Nili Zafrir, Per Albertsson, Toshiji Iwasaka, Ela Dhanak, Leon Lurje, Ezra A. Amsterdam, Michelle B. Sholar, Arthur J. Siegel, Fragola Pv, Aleksandar N. Neskovic, Tadayuki Hiroki, Kei Miyoshi, Avanindra Jain, Teruhiro Tamura, Kenneth Caidahl, Ivo Amende, O.N. Krogmann, A. Paulus, Paola Pivetti-Pezzi, Marco Ferro Luzzi, Tri Thuong Nguyen, Takayuki Furuki, Yi-Lwun Ho, Matthias Sturm, Erwin Blessing, Aleksandar D. Popovic, Göran Johansson, Yuan-Teh Lee, Maria Haglid, Shuji Kitashiro, Por-Jau Huang, Hanno Krauss, Francesco Ciciarello, Tsunehiko Nishimura, and Jane Yang
- Subjects
Index (economics) ,business.industry ,Statistics ,Medicine ,Pharmacology (medical) ,Subject (documents) ,Cardiology and Cardiovascular Medicine ,business - Published
- 1997
28. Choroidal lesions and surgical treatment of bullous retinal detachment
- Author
-
Yutaka Hasegawa, Shigeki Machida, Kazuhiko Hayashi, Kei Miyoshi, Kouichi Hai, and Yutaka Tazawa
- Subjects
Adult ,Indocyanine Green ,Male ,medicine.medical_specialty ,genetic structures ,Indocyanine green angiography ,Retinal detachment surgery ,Veins ,chemistry.chemical_compound ,Ophthalmology ,Humans ,Medicine ,Fluorescein Angiography ,Surgical treatment ,Sclerostomy ,Aged ,medicine.diagnostic_test ,Choroid ,business.industry ,Retinal Detachment ,Retinal detachment ,Retinal ,General Medicine ,Middle Aged ,Fluorescein angiography ,medicine.disease ,eye diseases ,chemistry ,Female ,sense organs ,business ,Indocyanine green ,Dilatation, Pathologic - Abstract
To define choroidal lesions of bullous retinal detachment, we performed indocyanine green angiography (IA) on 20 eyes of 10 patients with bullous retinal detachment. Four of these eyes were treated with sclerectomy and sclerostomy (Gass), and the benefit was evaluated. IA showed the following choroidal abnormalities: choroidal filling delay in the macular region (6 of 18 eyes, 33%) and underneath the leaking sites (9 of 18 eyes, 50%), localized (1 eye, 5%) and extended (18 eyes, 90%) choroidal venous dilatation, and intrachoroidal hyperfluorescence (all eyes, 100%). After the surgical treatment, retinal detachments resolved within 9 weeks (mean 5.3 weeks). Since choroidal filling delay, choroidal venous dilatation and intrachoroidal hyperfluorescence were observed, it is suggested that choroidal congestion plays a causative role in bullous retinal detachment. Sclerectomy and sclerostomy seemed to be beneficial in treatment of this condition.
- Published
- 1997
29. HIGHER CHYMASE DEPENDENT ANGIOTENSIN II-FORMING ACTIVITY IN THE CIRCULATING MONONUCLEAR LEUKOCYTE IS A SIGNIFICANT CONTRIBUTING FACTOR FOR ATRIAL FIBRILLATION
- Author
-
Sunao Kodama, Shunichiro Sumi, Yukiko Inoue, Shin-ichiro Miura, Keijiro Saku, Shodai Furuyama, Kenzo Matsumoto, Hidenori Urata, Hideya Niimura, Chie Andoh, Kei Miyoshi, Yoshinari Uehara, Keisuke Okamura, Yoshio Yamanouchi, Hideaki Tohjoh, Yusuke Fukuda, Seiyo Maruyama, and Kazumitsu Kubota
- Subjects
medicine.medical_specialty ,Mononuclear leukocyte ,Endocrinology ,business.industry ,Internal medicine ,medicine ,Cardiology ,Chymase ,Atrial fibrillation ,medicine.disease ,business ,Cardiology and Cardiovascular Medicine ,Angiotensin II - Full Text
- View/download PDF
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.