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Background: The prognosis of cancer survivors has dramatically improved, but effective strategies for cancer treatment-related cardiovascular disorders (CTRCD) remain to be elucidated in the emerging field of cardio-oncology. In this study, we investigated risk factors for CTRCD in breast cancer patients treated with trastuzumab. Methods and Results: We performed a retrospective analysis of 141 consecutive women who received adjuvant trastuzumab, and underwent baseline (BL) and follow-up (FU) echocardiography at Juntendo University between April 2010 and December 2016. The major concomitant treatment was anthracyclines in 94% and radiotherapy in 53%. During the median treatment period of 11 months, there were 22 (15.6%) cardiology consultations, 3 (2.1%) treatment interruptions with irreversible CTRCD, and no deaths. Left ventricular ejection fraction (LVEF) was decreased from a median 67.5% (BL) to 63.4% (FU; P

This study evaluated stages of health behavior change and the prevalence of physical inactivity, unhealthy eating, poor stress management, alcohol consumption, and smoking in Inner Mongolia...

Everolimus is an effective treatment for advanced and/or metastatic breast cancer, especially in hormone receptor-positive cases. However, adverse events have prevented considerable numbers of clinicians from using this drug. Herein, we reviewed our clinical experiences and endeavored to identify patients in whom the benefits of everolimus treatment would outweigh these adverse events. If measures were available to prevent or minimize adverse effects prior to treatment, everolimus would be a more widely applicable drug. This retrospective study involved 11 patients in whom nonresectable or recurrent breast cancers were treated with everolimus between April 2014 and January 2016. Two patients achieved a partial response (PR) and 4 showed stable disease (SD) (1 showed long SD, i.e., > 24 weeks). The response rate was 18%, and the clinical benefit rate (PR + long SD) was 27%. Regarding adverse events, interstitial pneumonia (grade 3) developed in 3 patients (18%), necessitating treatment discontinuation. When using everolimus, it may be important to select suitable patients for whom this treatment can be continued with sufficient control of adverse events. Herein, we provide information relevant to the clinical use of everolimus based on our daily practice experiences with this agent.

Aims Unhealthy eating behavior is a serious health concern among secondary school students in Inner Mongolia. To predict their healthy food choices and devise methods of correcting unhealthy choices, we sought to confirm the cross-cultural validity of the theory of planned behavior among Inner Mongolian students. Materials and methods A cross-sectional study, conducted between November and December 2014. Overall, 3047 students were enrolled. We devised a questionnaire based on the theory of planned behavior to measure its components (intentions, attitudes, subjective norms, and perceived behavioral control) in relation to healthy food choices; we also assessed their current engagement in healthy food choices. Results A principal component analysis revealed high contribution rates for the components (69.32%–88.77%). A confirmatory factor analysis indicated that the components of the questionnaire had adequate model fit (goodness of fit index = 0.997, adjusted goodness of fit index = 0.984, comparative fit index = 0.998, and root mean square error of approximation = 0.049). Notably, data from participants within the suburbs did not support the theory of planned behavior construction. Several paths did not predict the hypothesis variables. However, attitudes toward healthy food choices strongly predicted behavioral intention (path coefficients 0.49–0.77, p Conclusion Our results support that the theory of planned behavior can apply to secondary school students in urban areas. Furthermore, attitudes towards healthy food choices were the best predictor of behavioral intentions to engage in such choices in Inner Mongolian students.

The use of antibodies against programmed cell death 1 (PD-1), which block inhibitory T cell checkpoints, is a promising new therapy for advanced malignant melanoma and NSCLC. However, patients with autoimmune diseases were excluded at the clinical trial using such immune checkpoint inhibitor, because of the possibilities to worsen an adverse event of the autoimmune disease. Thus, the efficacy and toxicity of nivolumab using such cases have not been reported yet. A 70-year-old woman with bone and duodenal metastasis of primary mucosal melanoma with complications of the rheumatoid arthritis was treated with nivolumab. After 4 weeks injection of nivolumab, bone metastasis was diminished. After receiving six courses of nivolumab therapy, she maintained a complete response for 9 months, without rheumatic exacerbation or drug-related adverse events. Establishment of the biomarker of the effect prediction of the PD-1 antibody, the adverse event prediction will be important in future.

Categorization bias in social cognition is widely observed, as it is more beneficial to commit low-risk biases in order to reduce high-risk biases. Here, we hypothesized that a low capacity of self-protection leads to a biased social categorization of others as “harmful”. To examine this, silhouettes of human body, which had a sexually dimorphic cue (waist-to-hip ratio), were presented, and participants categorized the stimuli as being either “female” or “male”. Participants’ basic physical fitness was measured, and we manipulated exogenous physical load by either a heavy or a light backpack. Physical load did not significantly influence sex categorization. In contrast, only female participants tended to categorize the stimuli as “male” more, as basic physical fitness increased, suggesting that basic physical fitness, not physical load, affects sex categorization for females. Our findings shed new light on the role of fitness factors in social cognition.

The miniature faking effect is a perceptual phenomenon where life-sized objects and landscape in tilt-shift photographs are perceived to be miniature. Previous studies have contributed to the generation of miniature faking; these include blur (bokeh), camera angle, vantage point, and perceived distance. Although color has also been considered to be a crucial factor in inducing the miniature faking effect, research based on systematical manipulations of color attributes has not been conducted. In the present study, we conducted two experiments, namely, paper-based and display-based to control the color lightness and saturation of two bird'seye view photographs. The results showed that the rated miniature faking effect is dependent on alterations of color lightness and saturation. Higher saturation, whereas lower lightness was found to enhance the miniature faking effect. These results demonstrated the crucial role of color in inducing the perception of miniature faking and further provided new materials to explore the general cognitive mechanism involved in miniature faking.

Background: Cigarette smoking remains a significant public health problem. However, current treatment programs have not yet succeeded in sufficiently reducing smoking rates. The study aimed to examine whether patients’ recognition of “spirometric-lung-age (SLA)” estimated from spirometry data prompts smoking cessation. Methods: From December 2010 to September 2011, participating smokers were prospectively enrolled into the standardized smoking cessation program (Visits 1–5 for 12 weeks) and assigned single-blindly to either SLA assessment or control groups. The SLA group was informed of the estimated age of their lungs from spirometry analysis and given an opportunity to recognize the difference from their actual chronological age, whereas the control group was not. The primary calculation of outcome was the smoking quit rate on Visit 5, whereas the secondary end-point was the proportion of patients who remained abstinent 1 year later. Results: One hundred and twenty-six Japanese smokers (88 males) participated and were randomly assigned to the SLA group (n=52) or the control group (n=74). The smoking quit rate on Visit 5 was similar in the SLA assessment group and control group (59.6% vs . 41.9%; P=0.0700). However, the proportion of patients who remained abstinent 1 year later was similar in both groups (78.6% vs . 69.0%; P=0.5497). Multivariate logistic regression analysis after adjusting baseline characteristics demonstrated that telling patients their SLA, the use of varenicline, and age were significantly associated with smoking quit rate on Visit 5 whereas only age was associated with remaining abstinent 1 year later. Conclusions: Telling patients their SLA can become a useful tool prompting smoking cessation among Japanese smokers although other factors such as pharmacotherapy and age also influence the cessation of smoking.

The present study investigated whether aurally presented mimetic words affect the judgment of the final position of a moving object. In Experiment 1, horizontal apparent motion of a visual target was presented, and an auditory mimetic word of “byun” (representing rapid forward motion), “pitari” (representing stop of motion), or “nisahi” (nonsense syllable) was presented via headphones. Observers were asked to judge which of two test stimuli was horizontally aligned with the target. The results showed that forward displacement in the “pitari” condition was significantly smaller than in the “byun” and “nisahi” conditions. However, when non-mimetic but meaningful words were presented (Experiment 2), this effect did not occur. Our findings suggest that the mimetic words, especially that meaning stop of motion, affect spatial localization by means of mental imagery regarding “stop” established by the phonological information of the word.

It has been well known that habitual smoking accelerates premature skin ageing recognized as 'smoker's face'. However, the effect of smoking cessation on the appearance of skin has not been elucidated. The aim of this study was to evaluate objectively the effect of smoking cessation on the skin's appearance. The stratum corneum carbonyl protein level and skin colour of the cheek and the hand were measured. The change before and during the smoking cessation treatment (0, 2, 4, 8 and 12 weeks), and the success or failure in smoking cessation, was compared and examined. Eighty-four cases who had smoking cessation treatment were examined. The level of the stratum corneum carbonyl protein did not show any difference comparing before and after treatment for the smoking cessation success group and the failure group. The lightness of skin colour showed an upward tendency 4-12 weeks after starting the treatment in the success group and increased significantly compared with the failure group. The redness showed a significant decrease in comparison with before the treatment, and it also showed a significant decrease compared with the failure group. The yellowness did not show any clear tendency. Also, the haemoglobin showed a decreased tendency. Furthermore, multivariate statistical analysis showed a possibility that the lightness and haemoglobin could be changed by smoking cessation treatment. In conclusion, our study showed that an upward tendency of skin lightness was seen to correspond with a haemoglobin decrease accompanied by smoking cessation. If we can easily measure skin improvement as an effect of smoking cessation, it is thought to be a useful aid for smoking cessation support.

The present study examined whether implicit motion information from static images influences perceived duration of image presentation. In Experiments 1 and 2, we presented observers with images of a human and an animal character in running and standing postures. The results revealed that the perceived presentation duration of running images was longer than that of standing images. In Experiments 3 and 4, we used abstract block-like images that imitated the human figures used in Experiment 1, presented with different instructions to change the observers' interpretations of the stimuli. We found that the perceived duration of the block image presented as a man running was longer than that of the image presented as a man standing still. However, this effect diminished when the participants were told the images were green onions (objects with no implied motion), suggesting that the effect of implied motion cannot be attributed to low-level visual differences. These results suggest that implied motion increases the perceived duration of image presentation. The potential involvement of higher-order motion processing and the mirror neuron system is discussed.

In the scintillating grid illusion, illusory dark spots are perceived on white patches at the intersections of gray bars. Previous studies have suggested that processing related to the orientation of the bars plays a role in this illusion, but the specific underlying mechanisms are unclear. In the present study, we investigated the role of orientation processing across the intersection in generating the scintillating grid illusion. The results revealed that the illusion was attenuated when the patch was located at the intersection of short bars (Experiment 1), irrespective of the spatial distance between patches (Experiment 2). The local cruciform patterns determined the strength of the illusion, even when lateral offset of the patches was employed (Experiment 3). The illusion was observed even when a small spatial gap was introduced around the patches. A larger gap produced a weaker illusion (Experiment 4). Spatial offsets of the bars across the gapped intersection greatly reduced the illusion (Experiment 5). We discuss these findings with regard to the activity of S1-type simple cells that respond to the luminance along an oriented edge across the intersection.

Background: The lung is one of the sites of granulomatous responses, which are characterized by the recruitment and organization of activated macrophages and lymphocytes. There have been several reports that have shown that some pulmonary granulomatous diseases, such as sarcoidosis and nontuberculous mycobacterial disease, are likely to be characterized by a preponderance in postmenopausal females. Although sex hormones have been shown to play an important role in the regulation of the immune system, the influence of sex hormones on pulmonary granuloma formation is still unclear. Objectives: The purpose of this study was to assess whether sex hormones are involved in granulomatous inflammation and to evaluate how sex hormones modulate this response in the lung. Methods: Ovariectomized rats were used as an experimental postmenopausal model in which chronic pulmonary granulomatous inflammation was induced by intravenous injection of complete Freund’s adjuvant. Results: Histological analysis of lung tissues demonstrated enhancement of granuloma formation in the ovariectomized group. Such enhanced granuloma formation was significantly associated with generalized Th1-biased cytokine production in the bronchoalveolar lavage fluid. Conclusion: These results indicate that sex hormones play an important role in pulmonary granuloma formation by altering the Th1 responses.

The patient was 54-year-old woman diagnosed as recurrent invasive thymoma (type B3; WHO classification). Although partial response was obtained by systemic chemotherapy (PAC: cisplatin, doxorubicin, cyclophosphamide), the tumor started to become enlarged after cessation of chemotherapy. Combined treatment of octreotide and prednisolone was administrated because various chemotherapies, including PAC, were not effective. After seven months, the tumor size was markedly decreased. The combination of octreotide and prednisolone should be considered as one of the choices of treatment in patients with recurrent thymoma.

The scintillating grid illusion refers to the illusory perception of black spots on luminance patches at the intersections of a grey grid on a black background. We examined how spatial parameters of luminance patches modulated the strength of the illusion. In experiment 1, we controlled the size and shape of the luminance patches. For the largest-size conditions tested, we found a significant reduction in the strength of the illusion with squares when compared to circles or diamonds. In experiment 2, we controlled the orientation of quadrangle patches and confirmed a significantly larger reduction in the strength of the illusion when the edge orientations of quadrangle patches were vertical and horizontal (square) than when they were oblique (diamond). To explore the relationship between orientation processing and scintillating grid illusion, we controlled, in experiment 3, the global orientation of the display; the strength of the illusion with diamonds was significantly weaker when it was rotated by 45° than when it was not rotated. These results indicate that it is not only the difference of edge orientation of luminance patches, but also the orientation with respect to the grid that determines the strength of the illusion.

Visual attention automatically shifts in the direction of another person's gaze shift. However, this gaze cueing effect has been tested only in static situations. In the present study, we examined whether dynamic gaze cueing, triggered by the dynamic gaze shift of another person, could alter the perceived direction of apparent motion. In Experiment 1, we presented a drifting or counterphased flickering sinusoidal grating in the upper visual field and a pictorial face stimulus with its eyes smoothly moved towards the left or right side of the grating in the lower visual field. Observers were asked to report the perceived motion direction in the grating; consequently, it was biased in the direction of the gaze shift. In Experiment 2, we ruled out the possibility of motion capture due to the motion signals in the eyes as a source of bias in the previous experiment. From these results, we concluded that dynamic gaze cueing altered perceived motion direction, and we proposed the usefulness of our approach in exploring gaze perception in dynamic environments.

Motion lines (MLs) are a pictorial technique used to represent object movement in a still picture. This study explored how MLs contribute to motion perception. In Experiment 1, we reported the creation of a motion illusion caused by MLs: random displacements of objects with MLs on each frame were perceived as unidirectional global motion along the pictorial motion direction implied by MLs. In Experiment 2, we showed that the illusory global motion in the peripheral visual field captured the perceived motion direction of random displacement of objects without MLs in the central visual field, and confirmed that the results in Experiment 1 did not stem simply from response bias, but resulted from perceptual processing. In Experiment 3, we showed that the spatial arrangement of orientation information rather than ML length is important for the illusory global motion. Our results indicate that the ML effect is based on perceptual processing rather than response bias, and that comparison of neighboring orientation components may underlie the determination of pictorial motion direction with MLs.

In motion-induced blindness (MIB), a target within rotating random dots is occasionally hidden from observers' consciousness during observation. In the present study, a red ring-like cue was centered on a target and presented immediately after observers reported subjective disappearance of the target in MIB (Experiment 1). The radius of the cue was systematically modulated. Observers quickly regained awareness of the disappeared object only after they were provided with a pinpoint cue of its location. We also found that a flickering cue at 1Hz hindered MIB when the radius of the cue was critically small (Experiment 2). Furthermore, abrupt onset of a small square was enough to regain awareness of the target (Experiment 3). Successful revival of the target with a small cue indicates that critical spatial distribution of visual attention determines what in the visual scene is included in visual awareness.

This study explored how motion lines (ML) can contribute to the memory displacement of an object. Three experiments were conducted to examine the memorized position of a target with ML using manual localization tasks, revealing that the reproduced position was biased in the direction implied by the ML. Two further experiments successfully ruled out the possibility that the memory displacement stemmed from a repulsive manual localization tendency, an attention repulsion-like effect, or perceptual illusory displacement of the object. These results indicated that ML trigger anticipation of the future position of the object, resulting in memory displacement.

This study examined the subjective disappearance of a visual object induced by a neighboring flickering ring (Experiments 1 and 2), a set of four flickering dots (Experiment 3), and apparent motion (Experiment 4) as flickering flankers. Observers were asked to report whether a target disappeared during 10 s of stimulus presentation. We used the proportion of disappearance as a measure of performance. Interestingly, subjective disappearance was rarely observed when flickering flankers were presented with a separation of less than 0.5 degrees from the target. However, disappearance was observed when dynamic random-dot patterns were presented with a separation of less than 0.5 degrees from the target border (Experiment 5). Our results indicate that the flicker of flankers near the target disturbs target adaptation or attentional inhibition, causing persistent target representation in higher-order object selection, and resulting in non-disappearance of the target.

A novel illusion in apparent size is reported. We asked observers to estimate the width and depth of vertically oriented elliptic cylinders depicted with texture or luminance gradients (experiment 1), or the height of horizontally oriented elliptic cylinders depicted with binocular disparity (experiment 2). The estimated width or height of cylinders showed systematic shrinkage in the direction of the gradual depth change. The dissimilarity of 2-D appearance amongst our stimuli implies a large variation in spatial-frequency components and brightness contrasts, eliminating the possibility that these parameters contributed to the illusion. Also, the mechanism inappropriately triggered by pictorial depth cues (eg size scaling) may be irrelevant, because the illusion was obtained even when binocular disparity alone specified the shape of the cylinders. The illusion demonstrated here suggests that our visual system may determine the size of 3-D objects by accounting for their depth structures.

The present study examined the effect of coherence of moving visual objects on time perception. Participants observed stimuli composed of four line segments moving behind or in front of occluders. The line segments appeared to move either coherently as a diamond outline or incoherently, depending on the occlusion. Results from the temporal bisection task indicated that the duration of the coherently moving stimulus was perceived longer or shorter compared to the duration of the incoherently moving stimulus depending on the stimulus configurations. The speed comparison task revealed that the trend of the difference in perceived speed between the coherent and incoherent motions in each stimulus configuration was consistent with that of the difference in perceived duration between them. These results demonstrate the effect of motion coherence on perceived duration, and that this effect may be mediated by changes in perceived speed. Our finding provides evidence supporting the involvement of global motion processing in time perception.

Artists and cartoonists are able to dexterously depict a running person on paper with the aid of 'motion lines'. We scientifically examined whether the cognitive system can exploit motion lines in constructing memory representations of the location of a running person depicted in a still image. A target depicting a standing or a running person with or without motion lines was presented to participants for 500 ms. Observers were required to reproduce the location of the target 1 s after its disappearance. Data from depicted leftward and rightward moving persons were collapsed. Memory displacement of the target was shown to be largest in the presence of motion lines and a posture indicating an identical direction of movement. By assessing the absolute localization error, we showed that there was no localization advantage toward a target with a symmetrical (standing) posture over one with an asymmetrical (running) posture. Our findings indicate synergetic interaction between the mechanisms responsible for processing of motion lines and human postures in the representation of dynamic events.

In this study, we examined the contribution of the orientation of moving objects to perception of a streaming/bouncing motion display. In three experiments, participants reported which of the two types of motion, streaming or bouncing, they perceived. The following independent variables were used: orientation differences between Gabor micropatterns (Gabors) and their path of motion (all the experiments) and the presence/absence of a transient tone (Experiment 1), transient visual flash (Experiment 2), or concurrent secondary task (Experiment 3) at the coincidence of Gabors. The results showed that the events at coincidence generally biased responses toward the perception of bouncing. On the other hand, alignment of Gabors with their motion axes significantly reduced the frequency of bounce perception. The results also indicated that an object whose orientation was parallel to its motion path strengthened the spatiotemporal integration of local motion signals along a straight motion path, resulting in the perception of streaming. We suggest that the effect of collinearity between Gabors and their motion path is relatively free from the effect of attention distraction.

This study examined the involvement of second-order processing in the perception of transparency from texture. Stimuli consisted of two superimposed plaid patterns with two diagonal gratings defined by contrast modulation. We investigated the probability of reporting transparency (simultaneous percept of the two gratings) as functions of envelope frequency and either carrier frequency (Experiment 1) or carrier orientation (Experiment 2). Perception of transparency was more often with a large difference in carrier signals between the two gratings. Moreover, a lower envelope frequency was required for the perception of transparency. These results indicate that the mechanism responsible for texture transparency may tune to second-order structures that are differentiated in terms of first-order signals and that decomposition or integration of structures may be determined in terms of the difference of first-order signals between structures.

This paper reviews the literature on texture segregation and texture transparency, and proposes a new account of texture transparency based on the theory of texture segregation. To date, it has been suggested that the perception of transparency might stem from perceptual grouping or spacing effects between texture elements. Based on recent data, this paper argues that texture transparency should be explained by a Filter-Rectify-Filter mechanism, which underlies texture segregation; the integration of collinear texture edges and the separation of orthogonal texture edges at texture-defined junctions are a critical factor in causing texture transparency. Moreover, outstanding problems with the theory of texture transparency were discussed in terms of the nature of second-order junctions, the time-course of overlaid texture surfaces, and synergetic effects by combining several visual attributes such as orientation and spatial frequency.

We report on the reversal of asymmetry in visual-search tasks with shaded items. Previous studies have suggested that the target of a bottom-lit disk among distractors of top-lit disks is detected in a rapid and parallel manner, but not vice versa. However, in this study, we have shown that the compound items of top-lit disks were searched more quickly than those composed of bottom-lit disks where the items had to be segregated from their background. By modulating the inter-element distances, we confirmed that the reversal of search asymmetry cannot be due to the grouping of items. Further, we showed that the regions of the top-lit disks were perceived as figure more consistently than those of bottom-lit disks. The results indicate that the boundary assignment to the compound items of the top-lit disks enhances the segregation of search items from the background, and that the search mechanism may access the relatively higher representation that includes figure – ground relations.

This study examined the factors producing the perception of transparency between overlaid regions composed of Gabor micro-patterns as functions of their spatial frequency, separation of overlaid regions, and types of orientation modulation. The results showed that the likelihood of perceiving transparency was high both when (1) the difference in Gabor spatial frequency between regions was large, and (2) the region boundary, which was formed by short-range orientation differences in the Gabor micro-patterns, clearly emerged. We conclude that texture transparency appears to result from an interaction between a boundary-detection mechanism defining the shape of each region and a surface-detection mechanism assigning the boundary.

Using wall materials, we compared the impressions of objects when viewed in reality and when reproduced and viewed through visual media: a cathode ray tube (CRT) display and a video projector. The results showed that the materials were evaluated from three different perspectives: evaluation (preference), potency (solidity) and activity (diversity) and that the similarity of the walls was determined according to the two-dimensional characteristics of visual and tactile textures. Concerning the viewing condition it was found that: (i) a video projector can transmit information about color and pattern, but it cannot transmit enough texture, (ii) a CRT can transmit information about texture such as smoothness, as well as color and pattern, but it gives a tense impression, probably due to the image’s brightness and clarity, and (iii) seeing the objects in reality is the best way to evaluate their visual and factile textures. Although these findings showed the differences among the visual media used, the impression and evaluation of them were similar as a whole. We discussed this similarity of the judgement from the point of view of an observer’s ability to adjust to or to maintain a preset attitude to reproductions.

The present study demonstrated that friction cues for target motion affect time-to-contact (TTC) estimation. A circular target moved in a linear path with a constant velocity and was gradually occluded by a static rectangle. The target moved with forward and backward spins or without spin. Observers were asked to respond at the time when the moving target appeared to pass the occluder. The results showed that TTC was significantly longer in the backward spin condition than in the forward and without-spin conditions. Moreover, similar results were obtained when a sound was used to imply friction. Our findings indicate that the observer's experiential knowledge of motion coupled with friction intuitively modulated their TTC estimation.

Various autoimmune diseases have been reported to occur in patients with sarcoidosis. However, coexistence of sarcoidosis and antiphospholipid syndrome (APS) is extremely rare. We describe a 59-year-old female patient with pulmonary sarcoidosis who had preceding APS. Her previous medical history consisted of a miscarriage and ischemic colitis. She was diagnosed as APS during the onset of a brainstem infarction with positive reaction to beta2-glycoprotein I-dependent anticardiolipin antibody. Two years later, chest CT revealed enlargement of the hilar and mediastinal lymph nodes and small nodules in the lung fields. Transbronchial lung biopsy demonstrated non-caseating epithelioid cell granuloma leading to the diagnosis of definite pulmonary sarcoidosis. This is the first APS case where pulmonary involvement with sarcoidosis has been confirmed through lung biopsy. Our case report suggests that APS should be recognized as an accompanying disorder of sarcoidosis.

Here, we demonstrated that one's own name attracts the subjective location of a visual target. We simultaneously presented observers their own name and others' name in the left and right visual fields. A target circle was presented for 53 ms around the center of the display 200 ms after the names disappeared. Ten observers were required to manually reproduce the target location by pointing with the mouse. The results indicated that the observers significantly mislocalized the target 1.61' on average toward the location of their own name. These observations indicated that the visual space is distorted by one's own name, which biases the spatial distribution of visual attention.

We report a new illusion in which the edges of diamonds placed at the intersections of grids are perceived to be jaggy (the jaggy diamonds illusion). Interestingly, the illusion disappears when the stimulus is rotated by 45°, when the stimuli are observed at a close distance, and on the diamond at which the observers stare. Luminance contrast between diamonds, grids, and background is a strong determinant for this illusion.

The second of two targets (T2) embedded in a rapid serial visual presentation (RSVSVP) is often missed even though the first (T1) is correctly reported (attentional blink). The rate of correct T2 identification is quite high, however, when T2 comes immediately after T1 (lag-1 sparing). This study investigated whether and how non-target items induce lag-1 sparing. One T1 and two T2s comprising letters were inserted in distractors comprising symbols in each of two synchronised RSVSVPs. A digit (dummy) was presented with T1 in another stream. Lag-1 sparing occurred even at the location where the dummy was present (Experiment 1). This distractor-induced sparing effect was also obtained even when a Japanese katakana character (Experiment 2) was used as the dummy. The sparing effect was, however, severely weakened when symbols (Experiment 3) and Hebrew letters (Experiment 4) served as the dummy. Our findings suggest a tentative hypothesis that attentional set for item nameability is meta-categorically created and adopted to the dummy only when the dummy is nameable., This work was supported by a Grant-in-Aid for JSPS Fellows from the Japan Society for the Promotion of Science (Y.Y.) and the Kyushu University Research Superstar Program (T.K.).

This study investigated how spatial intervals between successive visual flashes are influenced by the temporal intervals between auditory pure tones presented concurrently with the flashes. Three successive visual flashes defined two spatial intervals with different extents as well as two equal temporal intervals. The onsets of the first and third tones were temporally aligned with those of the first and third flashes, while the onset of the second tone was temporally offset to that of the second visual flash, resulting in shorter or longer temporal intervals between pairs of tones. Observers judged which of the first or second spatial intervals between flashes was shorter. The results showed that the shorter temporal interval between tones caused underestimation of the spatial interval between flashes. On the other hand, stimuli without the first and third tones did not result in underestimation of spatial intervals between flashes. These results indicate an audiovisual tau effect, which is triggered by a constant velocity assumption applied to moving objects defined by more than one modality.

This study investigated how visual systems recover depth-order from orientation-defined junctions. Stimuli were superimposed stripes defined by Gabor micro-patterns (Gabors). In one stripe (random stripe), Gabor orientation was randomly selected from a given range, while in the other (constant stripe) it was selected so as to be different from the mean orientation of the random stripe by 90 degrees . Observers reported which of the two stripes, the right- or left-tilted one, they perceived as "nearer" than the other. Observers frequently reported that the random stripe was nearer than the constant stripe. The results appeared to stem from detection of discontinuity of texture edges of the constant stripe due to masking by the random stripe at junctions. This idea was confirmed in the following experiments where discontinuity of the texture edges at junctions was introduced by changing the Gabor luminance contrast in one stripe but keeping it intact in the other. The results indicated that processing of texture edges at junctions can contribute to the perception of depth-order.

This study was designed to ascertain whether the human visual system can segregate overlapped surfaces by integrating texture borders at second-order X-junctions. The stimuli used were crossed vertical and horizontal stripes consisting of Gabor micro-patterns. We manipulated the orientation of the center region of each stripe. Observers judged whether the crossed stripes appeared as "two overlapped stripes" or "five individual regions." The results showed that the probability of perceiving overlapped stripes exceeded the chance level (0.5) when the orientation differences between the center and flanking regions were less than 30 degrees. We suggest that the integration of texture borders along each stripe occurs by the filter-rectify-filter mechanism, resulting in the impression of overlapped surfaces. When this fails, the outcome is the perception of five individual regions.

Sarcoidosis is a systemic granulomatous disorder of unknown etiology, which involves the lung, eye, liver, and other organs. Vascular endothelial growth factor (VEGF) is a major regulator of angiogenesis involved in an important role in the development of granuloma. However, only a limited number of studies have reported on the relationship between serum VEGF values and the clinical status of sarcoidosis. Concentrations of serum VEGF were determined in 33 patients with sarcoidosis. We investigated the correlation between serum VEGF values and extent of disease, prognosis, and radiographic stage compared with serum angiotensin converting enzyme (ACE) values as another candidate. Concentrations of serum VEGF in patients who received corticosteroid treatment were significantly higher than those of patients with spontaneous remission (p < 0.05). In addition, serum VEGF values in patients with extrathoracic involvements were significantly higher than those of patients with sarcoid lesions limited to the thoracic space (p < 0.05), accompanied by a tendency to increase the number of organs involved. The values of serum ACE revealed no relationship to the values of serum VEGF, administration of corticosteroid, or extrathoracic involvements. We concluded that serum VEGF values in patients with sarcoidosis is a predictive factor in determining extrathoracic organ involvements and as a parameter for deciding the necessity of treatment with corticosteroid. Serum VEGF might be a useful marker as a prognostic indicator in sarcoidosis.