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Owing to the existence of power-hungry clock networks, synchronous CNN accelerators are hard to achieve further low power consumption. In this paper, we propose a novel clockless asynchronous CNN processing element, replacing clock networks with asynchronous handshake signals. And then we construct a CNN computation array based on our PE and implement it in standard ASIC design flow. In addition, compared with the synchronous version that works at 200MHz frequency, our design can realize about 5.70× power consumption saving and 5.59× power-efficiency improvement when working at 196.0MHz equivalent frequency.

The promise of immunotherapy for cancer therapy has not been fully fulfilled because portions of tumors are immunosuppressive. To tackle this challenge, the initiation of immune system by stimulator of interferon genes (STING) pathway is explored and multifunctional STING-activating nanoparticles are rationally designed for synergistic antitumor therapy. The STING-activating nanoparticles have a formulation of Mn3 O4 @Au-dsDNA/DOX, where dsDNA is used to activate STING for immunotherapy and doxorubicin (DOX) is chosen as a model drug for chemotherapy. The STING-mediated immunity is activated, inducing interferon-β (IFN-β) production, increasing T cell priming, and enhancing effector T cell infiltration. Combined with chemotherapy, STING-mediated immunotherapy shows good antitumor efficacy by inhibiting tumor growth and prolonging survival rate in vivo. The promise of cancer immunotherapy can be fulfilled by combining novel antitumor immunity with innovative nanotechnology, and chemotherapy and targeted therapies.