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PURPOSE The purpose of this study was to determine the effectiveness of mindfulness-based stress reduction (MBSR) and mindfulness-based cognitive therapy (MBCT) on depression, quality of life (QoL), and glycosylated hemoglobin (HbA1c) in people with diabetes. DESIGN A systematic literature review and meta-analysis was conducted. METHODS Eight databases (PubMed, Embase, the Cumulative Index to Nursing and Allied Health Literature [CINAHL], Cochrane, PsycINFO, and three Chinese databases) were searched for relevant studies from inception to December 2019. Only randomized controlled trials (RCTs) of MBSR and MBCT interventions for people with type 1 and type 2 diabetes were included. FINDINGS Nine studies described in 11 articles were included in the review. Meta-analysis showed a significant effect favoring MBSR and MBCT on depression (standardized mean difference -0.84; 95% confidence interval [CI] -1.16 to -0.51; p < .0001), the mental health composite score of QoL (mean difference [MD] 7.06; 95% CI 5.09 to 9.03; p < .00001), and HbA1c (MD -0.28; 95% CI -0.47 to -0.09; p = .004). However, effects on the physical health composite score of QoL have not been found. CONCLUSIONS MBSR and MBCT are beneficial in improving depression, the mental health composite score of QoL, and HbA1c in people with diabetes. More well-designed trials using longer follow-up measurements are needed. CLINICAL RELEVANCE MBSR and MBCT could be considered as effective complementary treatment alternatives for people with diabetes.

Background Lack of adequate self-care, frequent admissions, and poor quality of life are common and serious problems in adult patients with systemic lupus erythematosus (SLE). Some studies have revealed that transitional care is effective in improving self-care and quality of life as well as reducing rehospitalization rates. However, limited studies explored its effects in adult patients with SLE. Therefore, we performed a study to examine the effects of transitional care on self-care, readmission rates, and quality of life in adult patients with SLE. Methods This study was a single-center, single-blind, and parallel-group randomized controlled trial comparing transitional care with usual care in SLE patients from a university hospital in China. Evaluations were conducted at baseline before discharge and at 3 months after discharge by using hospital readmission rate, the Exercise of Self-Care Agency Scale, and the Medical Outcomes Study Short Form 36-item Health Survey for self-care and quality of life. Data were collected between June and December 2016. Results Compared with the usual care group, the transitional care group reported significantly greater improvement in self-care and quality of life. Additionally, the 30-day readmission rate for the patients in the transitional care group was significantly lower than in the usual care group, and this effect remained significant at 60 and 90 days after patient discharge. Conclusion This study shows that transitional care improves self-care and quality of life in adult patients with SLE and reduces readmissions. However, further studies are needed. Trial registration China clinical trial registry, ChiCTR-IPR-16007708. Registered January 5, 2016. Electronic supplementary material The online version of this article (10.1186/s13075-018-1670-4) contains supplementary material, which is available to authorized users.

Objective To study the association between the serum creatine kinase (CK) level and aggressive behavior in patients with schizophrenia. Method This retrospective study recruited 2780 Chinese patients with schizophrenia from January 2009 to December 2013 at the psychiatric inpatient units of West China Hospital. The diagnosis was made according to the DSM-IV criteria. The serum level of CK was checked. Results Aggressive behavior was positively correlated with the serum CK level (r = 0.262, p = 0.000). The OR value is 8.084 when comparing the high CK group and normal CK group prior to admission. The aggressive behavior rate in the 5 times group (serum level ≥ 1130 U/L) after admission (28.2%) is higher than the rate prior to admission (16.5%). Conclusion The aggressive patients with schizophrenia displayed increased serum CK level. It may be useful to include a lab test of CK level in patients with schizophrenia and history of aggression. It would help the staff to take precautions to protect the patients and others.

// An Hu 1 , Jing-Juan Huang 2 , Jing-Fei Zhang 1 , Wei-Jun Dai 1 , Rui-Lin Li 3 , Zhao-Yang Lu 3 , Jun-Li Duan 3 , Ji-Ping Li 4 , Xiao-Ping Chen 1 , Jing-Ping Fan 1, 5 , Wei-Hua Xu 1 and Hong-Liang Zheng 6 1 Department of Otolaryngology, Gongli Hospital, Second Military Medical University, Pudong New Area, Shanghai, 200135, China 2 Department of Cardiology, Shanghai Chest Hospital, Shanghai Jiaotong University, Shanghai, 200030, China 3 Department of Gerontology, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, 200092, China 4 Department of Otolaryngology, Renji Hospital, Shanghai Jiaotong University School of Medicine, Pudong New Area, Shanghai, 200127, China 5 Department of Otolaryngology-Head and Neck Surgery, Changzheng Hospital, Second Military Medical University, Shanghai, 200003, China 6 Department of Otolaryngology-Head and Neck Surgery, Changhai Hospital, Second Military Medical University, Shanghai, 200433, China Correspondence to: Jing-Juan Huang, email: hjjxinhua@163.com Keywords: cell cycle arrest, apoptosis, ATM/Chk2/p53 signal pathway, head and neck squamous cell carcinoma, curcumin Received: March 20, 2016 Accepted: March 31, 2017 Published: April 13, 2017 ABSTRACT Studies have demonstrated that curcumin (CUR) exerts its tumor suppressor function in a variety of human cancers including head and neck squamous cell carcinoma (HNSCC). However, the exact underlying molecular mechanisms remain obscure. Here, we aim to test whether CUR affects ATM/Chk2/p53 signaling pathway, leading to the induction of cell cycle arrest, inhibition of angiogenesis of HNSCC in vitro and in vivo . To this end, we conducted multiple methods such as MTT assay, Invasion assay, Flow cytometry, Western blotting, RT-PCR, and transfection to explore the functions and molecular insights of CUR in HNSCC. We observed that CUR significantly induced apoptosis and cell cycle arrest, inhibited angiogenesis in HNSCC. Mechanistically, we demonstrated that CUR markedly up-regulated ATM expression and subsequently down-regulated HIF-1α expression. Blockage of ATM production totally reversed CUR induced cell cycle arrest as well as anti-angiogenesis in HNSCC. Moreover, our results demonstrated that CUR exerts its antitumor activity through targeting ATM/Chk2/p53 signal pathway. In addition, the results of xenograft experiments in mice were highly consistent with in vitro studies. Collectively, our findings suggest that targeting ATM/Chk2/p53 signal pathway by CUR could be a promising therapeutic approach for HNSCC prevention and therapy.

Xia Xie, Hui Yang, Anliu Nie, Hong Chen,* Jiping Li* West China School of Nursing and Department of Nursing, West China Hospital, Sichuan University, Chengdu, China *These authors contributed equally to this work Purpose: The aim of this study was to determine the prevalence and predictors of medication nonadherence among patients with systemic lupus erythematosus (SLE) in Sichuan.Patients and methods: A cross-sectional investigation was performed. Participants were recruited by consecutive sampling from the Rheumatic Clinic of a university hospital between June and September 2016. Patients’ self-reported medication adherence was assessed by the eight-item Morisky Medication Adherence Scale. Additional surveys included patients’ demographics, and clinical and treatment characteristics. Logistic regression analysis was used to identify the predictors of medication nonadherence.Results: A total of 140 patients were included in analysis. The percentage of patients classified as nonadherent to medication was 75%. Low education, rural residency, childlessness, limited comprehension of medication instructions, side effects experienced, dissatisfaction with treatment and better physical health were associated with an increased risk of nonadherence.Conclusion: This study demonstrated a high prevalence of medication nonadherence among SLE patients in Sichuan, and factors associated with the nonadherence are multifaceted. Interventions for these factors, such as appropriate adjustment of the service resources for patients with rheumatic disease in rural communities and improved communication between the health care providers and the patients, may contribute to improve the medication adherence of this cohort. Keywords: systemic lupus erythematosus, medication management, adherence, predictors

In order to study the Kinect and Unity3D combined with the deeper application, based on the use of Kinect to identify the body and made a new attempt for the binding of Unity3D. Using Kinect to get the dynamic behavior in the scene of the human body, to achieve control of the Unity object in the scene. Build the virtual scene in Unity3D platform. The test shows that the use of Kinect for human behavior recognition and fast response, high accuracy. Otherwise, the use of Unity3D as a platform of virtual scene is fast and convenient, the combination is very suitable for the target system in various industries.

A new kind of combined finite element named three-dimensional virtual laminated element and its deduce process is introduced. The new finite element was proved to be convenient, accurate and efficient in the calculation of bridge structures by a modal test and corresponding numerical example. Then some research and discussion were done, which show that with small modal construction scale being comparative with beam element, the static and dynamic spatial behavior of complicated structures can be simulated precisely. Furthermore, it is sensitive to structural damages, and more damage information can be obtained than corresponding spatial beam element, which means it is highly promising in the application of structural damage detection.

The present study reports a rare case of a renal clear cell carcinoma with thyroid and parotid metastases. A 56-year-old female, with a painless, right preauricular mass present for 6 months was referred to Renji Hospital (Shanghai, China). Physical examination revealed a mass of 3×3 cm, which was smooth, firm, immobile and non-tender. There was no accompanying facial weakness. Parotid ultrasonography revealed a hypoechoic mass within the right parotid gland, which was potentially a parotid mixed tumor. In July 2011, the patient underwent a superficial parotidectomy with preservation of the facial nerve. Pathology confirmed as right parotid clear cell carcinoma (metastasis). The patient's relevant medical history included a right radical nephrectomy for renal clear cell carcinoma (clinical stage III) in 2004. Additionally, in 2009, the patient underwent a resection of thyroid metastatic renal cell carcinoma. To the best of our knowledge, no similar case has previously been reported in English-language literature. The present study discusses a case report, and investigates the clinical features and treatment strategy.

Learning is the major human activity which can make people to accommodate the environment or the society better. The effectiveness of learning is one important research issue in orange technology. The learning effectiveness of nurse education is more important than the other types of educations. In this paper, we proposed a work which develops a simulation-based digital courseware for intramuscular injection training in nurse education, to improve the learning effectiveness of practical nursing care training. The design of courseware is guided by the constructivism. In addition, the scenario simulation and game are involved to enhance the learning motivation. Moreover, the course has been successfully applied on the nursing students in Taiwan.

In this paper an initial study for intelligent servo control system is presented. We introduce the AL and Expert system technology to control field and proposed a two levels intelligent controller for instrument and measurement system. simulation study show such system has excellent dynamic performance and better robustness.

This paper reviews the concept, research condition and research progress of hierarchical division in nursing ladder management in China; points out the problem and outlook of this area.