Author: "Jeannet Lauenborg" / Topic: business - Searchworks@Jio Institute Digital Library Search Results

30 results on '"Jeannet Lauenborg"'

1. A flexible silicone patch for treatment of hemorrhoids after birth: a pilot study of HEMOCIN® Patch

Author: M Zara Siddiqi, Jeannet Lauenborg, Caroline B. Madsen, and Johan Tolstrup
Subjects: medicine.medical_specialty, Pregnancy, Medical treatment, business.industry, Gastroenterology, Treatment options, Intervention group, medicine.disease, Surgery, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Hemorrhoids, Silicone, chemistry, 030220 oncology & carcinogenesis, Intervention (counseling), medicine, 030211 gastroenterology & hepatology, business
Abstract: To test a non-pharmacological silicone patch for treatment of symptomatic hemorrhoids with focus on usability, safety, and self-reported short-term effect. Puerperal women in a Danish maternity ward were cluster randomized to treatment with the HEMOCIN® patch (intervention) or no systematic treatment (control group). On inclusion and after 2 weeks, they completed a questionnaire regarding history and hemorrhoid symptoms scored from 0 to 10. Women in the intervention group also reported on the usability of the patch and any side effects. We included 31 women in the intervention group and 33 in the control group. Twenty-eight (90.3%) women in the intervention group and 27 (81.8%) women in the control group responded to follow-up. Except from a difference in the severity of swelling at inclusion, there were no differences between the two groups for any symptoms, neither at inclusion, nor at follow-up, or in the change of symptoms during the two weeks (p > 0.05). Twenty-three women (85.2%) in the control group used medical treatment vs. one woman in the intervention group. The patch was used on an average of 9.3 days, 15.5 h/day and for 7.1 h before changing the patch. No severe side effects were reported. This pilot study finds that the HEMOCIN® patch is a safe and feasible treatment option for hemorrhoids. However, we did not detect any significant effect on hemorrhoid symptoms. The patch could be an option for people who seek non-pharmacological treatment for symptomatic hemorrhoids or need long-term treatment without steroid side effects.
Published: 2021

2. Screening for Gestational Diabetes Mellitus and Care of Diabetes Mellitus in Pregnancy

Author: Jeannet Lauenborg and Peter J. Hornnes
Subjects: Gestational diabetes, medicine.medical_specialty, Pregnancy, Obstetrics, business.industry, Diabetes mellitus, medicine, medicine.disease, business
Published: 2021

3. Validity of bladder volume measurement by ultrasound in women postpartum

Author: Niels Klarskov, Jeannet Lauenborg, and Josefine Tangen Jensen
Subjects: medicine.medical_specialty, Vaginal birth, Urology, media_common.quotation_subject, Urinary Bladder, 030232 urology & nephrology, urologic and male genital diseases, Urination, 03 medical and health sciences, 0302 clinical medicine, Pregnancy, Humans, Medicine, Prospective Studies, Ultrasonography, media_common, 030219 obstetrics & reproductive medicine, business.industry, Urinary retention, Vaginal delivery, Postpartum Period, Ultrasound, Obstetrics and Gynecology, Predictive value, Bladder volume, Female, Radiology, medicine.symptom, Urinary Catheterization, business, Volume (compression)
Abstract: Vaginal birth increases the risk of urinary retention and overdistention of the bladder. To avoid unnecessary discomfort by catheterization, it is preferable to use ultrasound for diagnosis of these conditions. The aim of this study was to determine the validity of transabdominal ultrasound and a portable ultrasound system, Biocon-700, to measure bladder volume in women postpartum. Fifty women were included in this method comparison study. Within 48 h of giving birth, their bladder volume was measured in randomized order with both transabdominal ultrasound and Biocon-700. After urination, participants were scanned with Biocon-700 to measure residual bladder volume, and finally the bladder was emptied by catheterization. The total bladder volume was calculated as the voided volume plus the catheterized volume. Biocon-700 measured 43.4 ml ± 117.4 ml (mean ± SD) lower than the total bladder volume, while volumes measured by transabdominal ultrasound were 117.8 ml ± 110.0 ml (mean ± SD) lower. Linear regression showed significant proportional bias in both methods. The Biocon-700 could detect a residual bladder volume > 150 ml with a positive predictive value of 66.7% and a negative predictive value of 100%. Neither transabdominal ultrasound nor the portable ultrasound system, Biocon-700, can be used to measure bladder volume precisely after vaginal delivery. However, both ultrasound methods can be used as screening tools to prevent overdistention of the bladder, and Biocon-700 can furthermore be used to screen women for a residual bladder volume > 150 ml.
Published: 2019

4. Changing incidence of obstetric anal sphincter injuries—A result of formal prevention programs?

Author: Hanna Jangö, Jeannet Lauenborg, Jens Langhoff-Roos, Anette Kjaerbye-Thygesen, and Hanne Brix Westergaard
Subjects: medicine.medical_specialty, 030219 obstetrics & reproductive medicine, Vaginal delivery, business.industry, Incidence (epidemiology), Prevalence, Psychological intervention, Obstetrics and Gynecology, Retrospective cohort study, General Medicine, Odds ratio, 03 medical and health sciences, 0302 clinical medicine, Emergency medicine, medicine, 030212 general & internal medicine, Risk assessment, business, Cohort study
Abstract: Introduction Obstetric anal sphincter injuries (OASIS) are serious complications to vaginal delivery causing anal incontinence in 50% of the women in the long term. In Norway, the incidence of OASIS has been significantly reduced from 4%-5% to 1%-2% after implementation of prevention programs focusing on perineal protection. The aim of our study was to evaluate whether implementation of formal prevention programs was associated with a reduced incidence of OASIS over time. Material and methods We performed a historical cohort study, evaluating incidence, change of incidence and risk factors of OASIS during the years 2011-2015 at the four delivery departments in the Capital Region of Denmark. Two of the four departments implemented formal prevention programs in 2012-2013. We performed trend tests and uni- and multivariable analyses, adjusting for important risk factors and calculating interactions between risk factors. Results There were 75 173 vaginal deliveries during the study period; of those, 2670 (3.6%) were complicated by OASIS. The incidence of OASIS decreased during the study period from 4.3% (n = 636) in 2011 to 2.6% (n = 399) in 2015. There was a significant decrease in the incidence of OASIS at both the departments with formal prevention programs and those without. After adjustment for other important risk factors of OASIS, we found no significant difference in the risk reduction between departments with and without formal prevention programs. Conclusions We found that the general focus on prevention of OASIS in Denmark was associated with a significant decrease in the incidence of OASIS, but implementation of formal prevention programs did not lead to a further reduction. It is possible that more rigorous interventions at the hospitals with formal prevention programs could have resulted in a significant difference in incidence of OASIS.
Published: 2019

5. The increasing role of a retained placenta in postpartum blood loss: a cohort study

Author: Jens Svare, Jeannet Lauenborg, Hellen McKinnon Edwards, Jens Langhoff-Roos, and Anne Juul Wikkelsø
Subjects: Adult, medicine.medical_specialty, Multivariate analysis, Cohort Studies, Young Adult, Blood loss, Pregnancy, Risk Factors, Retained placenta, Bayesian multivariate linear regression, Humans, Medicine, Young adult, reproductive and urinary physiology, Retrospective Studies, business.industry, Obstetrics, Postpartum Hemorrhage, Obstetrics and Gynecology, Retrospective cohort study, General Medicine, medicine.disease, embryonic structures, Female, business, Labor Stage, Third, Placenta, Retained, Cohort study
Abstract: To describe the association between quantity of blood loss, duration of the third stage of labour, retained placenta and other risk factors, and to describe the role of a retained placenta depending on the cutoff used to define postpartum haemorrhage.Cohort study of all vaginal deliveries at two Danish maternity units between 1 January 2009 and 31 December 2013 (n = 43,357), univariate and multivariate linear regression statistical analyses.A retained placenta was shown to be a strong predictor of quantity of blood loss and duration of the third stage of labour a weak predictor of quantity of blood loss. The predictive power of the third stage of labour was further reduced in the multivariate analysis when including retained placenta in the model. There was an increase in the role of a retained placenta depending on the cutoff used to define postpartum haemorrhage, increasing from 12% in cases of blood loss ≥ 500 ml to 53% in cases of blood loss ≥ 2000 ml CONCLUSION: The predictive power of duration of the third stage of labour in regard to postpartum blood loss was diminished by the influence of a retained placenta. A retained placenta was, furthermore, present in the majority of most severe cases.
Published: 2019

6. Comparative Studies of the Gut Microbiota in the Offspring of Mothers With and Without Gestational Diabetes

Author: Mie Korslund Wiinblad Crusell, Tue Haldor Hansen, Trine Nielsen, Kristine Højgaard Allin, Malte C. Rühlemann, Peter Damm, Henrik Vestergaard, Christina Rørbye, Niklas Rye Jørgensen, Ole Bjarne Christiansen, Femke-Anouska Heinsen, Andre Franke, Torben Hansen, Jeannet Lauenborg, and Oluf Pedersen
Subjects: 0301 basic medicine, Microbiology (medical), Adult, Blood Glucose, Offspring, 030106 microbiology, Immunology, lcsh:QR1-502, Physiology, Mothers, Disease, Gut flora, Microbiology, bacterial genera, lcsh:Microbiology, 03 medical and health sciences, Cellular and Infection Microbiology, Pregnancy, RNA, Ribosomal, 16S, Medicine, Humans, infancy, Child, Feces, Original Research, biology, gut microbiota, business.industry, Confounding, Infant, Newborn, Infant, biology.organism_classification, medicine.disease, Gastrointestinal Microbiome, Gestational diabetes, Diabetes, Gestational, 030104 developmental biology, Infectious Diseases, Gestation, Blood sugar regulation, Female, gestational diabetes, maternal glycaemic traits, business
Abstract: Background: Offspring of mothers with gestational diabetes mellitus (GDM) have increased risk of developing metabolic disorders as they grow up. Microbial colonization of the newborn gut and environmental exposures affecting the configuration of the gut microbiota during infancy have been linked to increased risk of developing disease during childhood and adulthood. In a convenience sample, we examined whether the intestinal tract of children born to mothers with GDM is differentially colonized in early life compared to offspring of mothers with normal gestational glucose regulation. Secondly, we examined whether any such difference persists during infancy, thus potentially conferring increased risk of developing metabolic disease later in life. Methods: Fecal samples were collected from children of mothers with (n = 43) and without GDM (n = 82) during the first week of life and again at an average age of 9 months. The gut microbiota was characterized by 16S rRNA gene amplicon sequencing (V1–V2). Differences in diversity and composition according to maternal GDM status were assessed, addressing potential confounding by mode of delivery, perinatal antibiotics treatment, feeding and infant sex. Results: Children of mothers with GDM were featured by a differential composition of the gut microbiota, both during the first week of life and at 9 months, at higher taxonomic and OTU levels. Sixteen and 15 OTUs were differentially abundant after correction for multiple testing during the first week of life and at 9 months, respectively. Two OTUs remained differentially abundant after adjustment for potential confounders both during the first week of life and at 9 months. Richness (OTU) was decreased in neonates born to mothers with GDM; however, at 9 months no difference in richness was observed. There was no difference in Shannon's diversity or Pielou's evenness at any timepoint. Longitudinally, we detected differential changes in the gut microbiota composition from birth to infancy according to GDM status. Conclusion: Differences in glycaemic regulation in late pregnancy is linked with relatively modest variation in the gut microbiota composition of the offspring during the first week of life and 9 months after birth.
Published: 2020

7. Gestational diabetes and the human salivary microbiota: a longitudinal study during pregnancy and postpartum

Author: Trine Nielsen, Lærke R. Brink, Kristine H. Allin, Mie Crusell, Tue H. Hansen, Oluf Pedersen, Peter Damm, Torben Hansen, and Jeannet Lauenborg
Subjects: medicine.medical_specialty, Longitudinal study, Multivariate analysis, Reproductive medicine, Physiology, Type 2 diabetes, Gestational hyperglycaemia, Salivary microbiota, Gestational diabetes mellitus, lcsh:Gynecology and obstetrics, Preeclampsia, 03 medical and health sciences, 0302 clinical medicine, Pregnancy, Diabetes mellitus, medicine, lcsh:RG1-991, 030304 developmental biology, 0303 health sciences, Glycaemic traits, business.industry, Obstetrics and Gynecology, 030206 dentistry, medicine.disease, Gestational diabetes, business, Research Article, Bacterial species
Abstract: Background An aberrant composition of the salivary microbiota has been found in individuals with type 2 diabetes, and in pregnant women salivary microbiota composition has been associated with preeclampsia and pre-term birth. Pregnant women, who develop gestational diabetes (GDM), have a high risk of developing type 2 diabetes after pregnancy. In the present study we assessed whether GDM is linked to variation in the oral microbial community by examining the diversity and composition of the salivary microbiota. Method In this observational study the salivary microbiota of pregnant women with GDM (n = 50) and normal glucose regulation (n = 160) in third trimester and 9 months postpartum was assessed by 16S rRNA gene amplicon sequencing of the V1-V3 region. GDM was diagnosed in accordance with the International Association of the Diabetes and Pregnancy Study Groups (IADPSG) criteria. Cross-sectional difference in alpha diversity was assessed using Student’s t-test and longitudinal changes were assessed by mixed linear regression. Cross-sectional and longitudinal difference in beta diversity was assessed by permutational multivariate analyses of variance. Differentially abundant genera and OTUs were identified by negative binomial regression. Results In the third trimester, two species-level operational taxonomic units (OTUs), while eight OTUs postpartum were differentially abundant in women with GDM compared with normoglycaemic women. OTU richness, Shannon diversity and Pielou evenness decreased from late pregnancy to 9 months after delivery regardless of glycaemic status. Conclusion GDM is associated with a minor aberration of the salivary microbiota during late pregnancy and postpartum. For unknown reasons richness of the salivary microbiota decreased from late pregnancy to postpartum, which might be explained by the physiological changes of the immune system during human pregnancy.
Published: 2020

8. Newborn body composition after maternal bariatric surgery

Author: Emma Malchau Carlsen, Bertha Kanijo Møller, Kristina M Renault, Ole Pryds, Dina Cortes, Jeannet Lauenborg, Kirsten Nørgaard, and Jens-Erik Beck Jensen
Subjects: Male, Physiology, Maternal Health, Bariatric Surgery, Biochemistry, Body Mass Index, Fats, Fetal Development, Families, Postoperative Complications, 0302 clinical medicine, Pregnancy, Weight loss, Medicine and Health Sciences, Birth Weight, 030212 general & internal medicine, Children, 030219 obstetrics & reproductive medicine, Multidisciplinary, Obstetrics and Gynecology, Gestational age, Lipids, Obesity, Morbid, Physiological Parameters, Obstetric Procedures, Infant, Small for Gestational Age, Body Composition, Medicine, Female, medicine.symptom, Infants, Research Article, Adult, medicine.medical_specialty, Offspring, Science, Birth weight, Surgical and Invasive Medical Procedures, Digestive System Procedures, 03 medical and health sciences, Weight Loss, medicine, Humans, Obesity, business.industry, Body Weight, Infant, Newborn, Biology and Life Sciences, Neonates, nutritional and metabolic diseases, medicine.disease, Surgery, Pregnancy Complications, Age Groups, People and Places, Women's Health, Population Groupings, business, Weight gain, Body mass index, Developmental Biology
Abstract: Introduction In pregnancy after Roux-en-Y gastric bypass (RYGB), there is increased risk of low birthweight in the offspring. The present study examined how offspring body composition was affected by RYGB. Material and methods Mother-newborn dyads, where the mothers had undergone RYGB were included. Main outcome measure was neonatal body composition. Neonatal body composition was assessed by dual-energy X-ray absorptiometry scanning (DXA) within 48 hours after birth. In a statistical model offspring born after RYGB were compared with a reference material of offspring and analyses were made to estimate the effect of maternal pre-pregnancy body mass index (BMI), gestational weight gain, parity, gestational age at birth and newborn sex on newborn body composition. Analyses were made to estimate the impact of maternal weight loss before pregnancy and of other effects of bariatric surgery respectively. The study was performed at a university hospital between October 2012 and December 2013. Results We included 25 mother-newborn dyads where the mothers had undergone RYGB and compared them to a reference material of 311 mother-newborn dyads with comparable pre-pregnancy BMI. Offspring born by mothers after RYGB had lower birthweight (335g, p
Published: 2020

9. Maternal Long-Term Outcomes after a Pregnancy Complicated by Gestational Diabetes Mellitus

Author: Jeannet Lauenborg, Mie Crusell, Peter Damm, and Elisabeth R. Mathiesen
Subjects: Gestational diabetes, Pregnancy, medicine.medical_specialty, business.industry, Obstetrics, medicine, Long term outcomes, medicine.disease, business
Published: 2019

10. The incidence of obstetric anal sphincter injury depends on both correct diagnosis and preventive strategies

Author: Anette Kjaerbye-Thygesen, Hanna Jangö, Jens Langhoff-Roos, Hanne Brix Westergaard, and Jeannet Lauenborg
Subjects: Pregnancy, medicine.medical_specialty, Obstetrics, business.industry, Incidence, Incidence (epidemiology), MEDLINE, Anal Canal, Obstetrics and Gynecology, General Medicine, Anal canal, medicine.disease, Obstetric Labor Complications, Obstetric labor complication, medicine.anatomical_structure, medicine, Humans, Fecal incontinence, Female, medicine.symptom, Anal sphincter, business, Fecal Incontinence
Published: 2019

11. Continuous focus on preventive strategies and follow up is important for a change

Author: Anette Kjaerbye-Thygesen, Hanne Brix Westergaard, Jens Langhoff-Roos, Hanna Jangö, and Jeannet Lauenborg
Subjects: Focus (computing), Medical education, business.industry, Risk Factors, Incidence, Obstetrics and Gynecology, Medicine, Anal Canal, General Medicine, Longitudinal Studies, business, Follow-Up Studies
Published: 2019

12. Gestational diabetes mellitus and long-term consequences for mother and offspring: a view from Denmark

Author: Azadeh Houshmand-Oeregaard, Louise Kelstrup, Jeannet Lauenborg, Elisabeth R. Mathiesen, Tine D. Clausen, and Peter Damm
Subjects: medicine.medical_specialty, Fetus, Pregnancy, endocrine system diseases, Offspring, Obstetrics, business.industry, Endocrinology, Diabetes and Metabolism, nutritional and metabolic diseases, 030209 endocrinology & metabolism, Type 2 diabetes, medicine.disease, Obesity, Gestational diabetes, 03 medical and health sciences, 0302 clinical medicine, Endocrinology, Internal medicine, Diabetes mellitus, Internal Medicine, medicine, 030212 general & internal medicine, Metabolic syndrome, business
Abstract: Gestational diabetes mellitus (GDM) is defined as glucose intolerance of varying severity and is present in about 2-6% of all pregnancies in Europe, making it one of the most common pregnancy disorders. Aside from the short-term maternal, fetal and neonatal consequences associated with GDM, there are long-term consequences for both mother and child. Although maternal glucose tolerance often normalises shortly after pregnancy, women with GDM have a substantially increased risk of developing type 2 diabetes later in life. Studies have reported that women are more than seven times as likely to develop diabetes after GDM, and that approximately 50% of mothers with GDM will develop diabetes within 10 years, making GDM one of the strongest predictors of type 2 diabetes. In women with previous GDM, development of type 2 diabetes can be prevented or delayed by lifestyle intervention and/or medical treatment. Systematic follow-up programmes would be ideal to prevent progression of GDM to diabetes, but such programmes are unfortunately lacking in the routine clinical set-up in most countries. Studies have found that the risks of obesity, the metabolic syndrome, type 2 diabetes and impaired insulin sensitivity and secretion in offspring of mothers with GDM are two- to eightfold those in offspring of mothers without GDM. The underlying pathogenic mechanisms behind the abnormal metabolic risk profile in offspring are unknown, but epigenetic changes induced by exposure to maternal hyperglycaemia during fetal life are implicated. Animal studies indicate that treatment can prevent long-term metabolic complications in offspring, but this remains to be confirmed in humans. Thus, diabetes begets diabetes and it is likely that GDM plays a significant role in the global diabetes epidemic. This review summarises a presentation given at the 'Gestational diabetes: what's up?' symposium at the 2015 annual meeting of the EASD. It is accompanied by two other reviews on topics from this symposium (by Marja Vaarasmaki, DOI: 10.1007/s00125-016-3976-6 , and by Cuilin Zhang and colleagues, DOI: 10.1007/s00125-016-3979-3 ) and an overview by the Session Chair, Kerstin Berntorp (DOI: 10.1007/s00125-016-3975-7 ).
Published: 2016

13. A Time Interval of More Than 18 Months Between a Pregnancy and a Roux-en-Y Gastric Bypass Increases the Risk of Iron Deficiency and Anaemia in Pregnancy

Author: Mie Crusell, Lisbeth Nilas, Jeannet Lauenborg, and Jens Svare
Subjects: Adult, Gestational hypertension, medicine.medical_specialty, Time Factors, Anemia, Endocrinology, Diabetes and Metabolism, Birth weight, Gastric Bypass, Intrauterine growth restriction, 030209 endocrinology & metabolism, Prenatal care, 03 medical and health sciences, 0302 clinical medicine, Pregnancy, medicine, Humans, Obesity, Retrospective Studies, 030219 obstetrics & reproductive medicine, Nutrition and Dietetics, Anemia, Iron-Deficiency, Obstetrics, business.industry, Pregnancy Outcome, Prenatal Care, Iron deficiency, medicine.disease, Nutrition Disorders, Pregnancy Complications, Cross-Sectional Studies, Ferritins, Female, Surgery, business, Body mass index
Abstract: The aim of the study is to explore the impact of time between Roux-en-Y gastric bypass (RYGB) and pregnancy on obstetrical outcome and nutritional derangements. In a retrospective cross-sectional study of pregnant women admitted for antenatal care at two tertiary hospitals, we examined 153 women with RYGB and a singleton pregnancy of at least 24 weeks. The women were stratified according to a pregnancy
Published: 2016

14. Ponderal index at birth associates with later risk of gestational diabetes mellitus

Author: Torben Hansen, Charlotte Glümer, Peter Damm, Oluf Pedersen, Allan Vaag, Jeannet Lauenborg, and Mie Crusell
Subjects: Adult, Blood Glucose, medicine.medical_specialty, endocrine system diseases, Birth weight, Population, 030209 endocrinology & metabolism, 03 medical and health sciences, 0302 clinical medicine, Insulin resistance, Pregnancy, Risk Factors, Journal Article, Odds Ratio, Medicine, Birth Weight, Humans, Insulin, 030212 general & internal medicine, education, education.field_of_study, business.industry, Obstetrics, nutritional and metabolic diseases, Obstetrics and Gynecology, Type 2 Diabetes Mellitus, General Medicine, Odds ratio, medicine.disease, female genital diseases and pregnancy complications, Gestational diabetes, Low birth weight, Diabetes, Gestational, Glucose, Diabetes Mellitus, Type 2, Cohort, Female, medicine.symptom, business, Follow-Up Studies
Abstract: PURPOSE: Low birth weight (BW) and low ponderal index (PI) are associated with increased risk of type 2 diabetes mellitus. This study has two purposes: first to investigate the influence of PI on the risk of gestational diabetes mellitus (GDM); second, to study the association between glucose metabolism and BW in women with previous GDM.METHODS: GDM cohort: 185 women with GDM in 1978-1996, attending a follow-up study in 2000-2002. Control cohort: 1137 women from a population-based diabetes screening study (Inter99) in a neighbouring county in 1999-2001. BW and birth length were collected from the original midwifery records. BW and PI were stratified into tertiles for analysis.RESULTS: PI in the lower tertiles was associated with an increased risk of GDM [odds ratio 1.59 (95% confidence interval 1.07-2.36, p = 0.021)]. Among women with previous GDM, the area under the curve (AUC) for plasma levels of glucose and insulin during an OGTT was highest for the lower tertiles of BW (for AUCglucose p = 0.048, for AUCinsulin p = 0.047 adjusted for age and BMI).CONCLUSIONS: Lower PI is associated with increased risk of GDM. In women with previous GDM, lower BW is associated with a more severe impairment of glucose metabolism one to two decades after the pregnancy complicated by GDM.
Published: 2017

15. High Prevalence of Diabetes-Predisposing Variants in MODY Genes Among Danish Women With Gestational Diabetes Mellitus

Author: Jun Wang, Ivan Brandslund, Peter Damm, Torben Hansen, Mette Hollensted, Niels Grarup, Jeannet Lauenborg, Shi Quan, Anette P. Gjesing, Ehm A. Andersson, Oluf Pedersen, Gao Rui, Christian Theil Have, and Jihua Sun
Subjects: 0301 basic medicine, medicine.medical_specialty, endocrine system, Diabetes, Pancreatic and Gastrointestinal Hormones, Endocrinology, Diabetes and Metabolism, Context (language use), 03 medical and health sciences, Internal medicine, Diabetes mellitus, medicine, Journal Article, genes, Research Articles, Pregnancy, business.industry, genetic screening, Anthropometry, medicine.disease, HNF1B, 3. Good health, HNF1A, Gestational diabetes, 030104 developmental biology, monogenic diabetes, MODY, gestational diabetes, business, Biomedical sciences
Abstract: Context: Gestational diabetes mellitus (GDM), defined as any degree of glucose intolerance with first recognition during pregnancy, is a heterogeneous form of diabetes characterized by various degrees of β-cell dysfunction. Objectives: We aimed to estimate the prevalence of possibly pathogenic variants in the maturity-onset diabetes of the young genes GCK, HNF1A, HNF4A, HNF1B, and INS among women with GDM. Furthermore, we examined the glucose tolerance status in variant carriers vs noncarriers at follow-up. Design, Setting, and Patients: We sequenced the coding regions and intron/exon boundaries of GCK, HNF1A, HNF4A, HNF1B, and INS using targeted region capture and next-generation sequencing in 354 Danish women with diet-treated GDM. Glucose tolerance was examined at follow-up 10 years after the index pregnancy. Main Outcome Measures: The prevalence of possibly pathogenic variants in GCK, HNF1A, HNF4A, HNF1B, and INS was estimated, and differences in anthropometric traits, high-sensitivity C-Reactive Protein (CRP), and glucose metabolism were measured. Results: At baseline, 17 possibly disease-causing variants were found in 21 women, revealing a combined GCK, HNF1A, HNF4A, HNF1B, and INS variant prevalence of 5.9% (95% confidence interval: 3.5% to 8.4%). At follow-up, 15 out of 135 women with diabetes (11%) were carriers of variants in GCK, HNF1A, HNF4A, HNF1B, or INS. Conclusions: Almost 6% of Danish women with diet-treated GDM have possibly pathogenic variants in GCK, HNF1A, HNF4A, HNF1B, or INS. These women are at high risk of developing diabetes after pregnancy. Thus screening for variants in GCK, HNF1A, HNF4A, HNF1B, and INS should be considered among women with GDM., Almost 6% out of 354 Danish women with diet-treated gestational diabetes mellitus carried possibly pathogenic diabetes-predisposing variants in the MODY genes GCK, HNF1A, HNF4A, HNF1B, and INS.
Published: 2017

16. The Impact of Upper Abdominal Pain During Pregnancy Following a Gastric Bypass

Author: Jeannet Lauenborg, Liselotte Petersen, Jens Svare, and Lisbeth Nilas
Subjects: Adult, medicine.medical_specialty, Endocrinology, Diabetes and Metabolism, Gastric bypass, Gastric Bypass, Intrauterine growth restriction, 030209 endocrinology & metabolism, Gestational Age, 03 medical and health sciences, Young Adult, 0302 clinical medicine, Pregnancy, medicine, Birth Weight, Humans, Mesentery, 030212 general & internal medicine, Nutrition and Dietetics, business.industry, Infant, Newborn, Pregnancy Outcome, nutritional and metabolic diseases, medicine.disease, Surgery, Abdominal Pain, Hernia, Abdominal, Obesity, Morbid, Pregnancy Complications, Upper abdominal pain, Female, business
Abstract: The aim of the present study was to describe the risk of internal herniation (IH) and the obstetric outcome in pregnant women with Roux-en-Y gastric bypass (RYGB) and episodes of upper abdominal pain.The cohort included 133 women with RYGB: 94 with 113 pregnancies, from the local area referred for routine antenatal care (local cohort) and 39 with 40 pregnancies referred from other hospitals for specialist consultation due to RYGB. RYGB was mainly performed without closure of the mesenteric defects. Data collected from medical records were episodes of upper abdominal pain, pregestational and gestational abdominal surgery and pregnancy outcome. The risk of upper abdominal pain was estimated in the local cohort. Surgical intervention, IH and obstetric outcome according to pain were evaluated for 139 pregnancies with delivery of a singleton after 24 weeks of gestation (birth cohort).Upper abdominal pain complicated 42/113 (37.2 %) pregnancies in the local cohort and 11 women (9.7 %) had IH. In the birth cohort, upper abdominal pain complicated 64/139 (46.0 %) pregnancies; surgery was performed in 30/64 (46.9 %), and IH diagnosed in 21/64 (32.8 %). The median gestational age at onset of pain was 25 + 3 weeks. Women reporting abdominal pain had a higher risk of preterm birth (n = 14/64 vs. 1/75, p 0.005), lower median gestational length (269 vs. 278 days, p 0.005) and lower median birth weight (3018 vs. 3281 g, p = 0.002) compared to women without abdominal pain.Upper abdominal pain during pregnancy is frequent among women with Roux-en-Y gastric bypass, is often due to IH and is associated with adverse pregnancy outcome.
Published: 2016

17. The influence of parental history of diabetes and offspring birthweight on offspring glucose metabolism in adulthood

Author: Peter Damm, Søren A. Urhammer, Hans Eiberg, Jeannet Lauenborg, Torben Hansen, Oluf Pedersen, Mie K W Jørgensen, and Atheline Major-Pedersen
Subjects: Glucose tolerance test, education.field_of_study, medicine.medical_specialty, Pregnancy, medicine.diagnostic_test, Offspring, business.industry, Birth weight, Population, Obstetrics and Gynecology, General Medicine, Type 2 diabetes, medicine.disease, Insulin resistance, Endocrinology, Internal medicine, Diabetes mellitus, medicine, education, business
Abstract: Background. Links are well established between both family history of diabetes and reduced birthweight and increased risk of diabetes in adulthood. Objectives. 1) To investigate the influence of parental history of type 2 diabetes (T2DM) on offspring birthweight and adult offspring glucose tolerance status in non-diabetic offspring of patients with T2DM and 2) to study the associations of birthweight with measures of pancreatic beta-cell function and insulin sensitivity. Design. Family cohort study. Population. Offspring of patients with verified T2DM diagnosed after age 40 years with a spouse without known diabetes. Methods. Oral glucose tolerance tests and frequently sampled intravenous glucose tolerance tests (FSIGT) in nondiabetic offspring. Birthweight and length obtained from birth records. Results. Among 122 offspring with maternal history of T2DM, 14.8% had diabetes compared to 8.0% in 137 offspring with paternal history of diabetes, p=0.09. Offspring with maternal history of T2DM had a mean birthweight 196g higher than offspring with paternal T2DM (3 651±640g (mean±SD) vs. 3 456±472g (p=0.01)). Nondiabetic offspring with birthweights in the lowest tertile had significantly higher plasma glucose levels after an oral glucose tolerance test (OGTT) [Area under the curveglucOGTT, mean (95%CI), 1 795 (1 725‐1 866) vs. 1 683 (1 613‐1 753) mmol/L/min, p=0.02], and lower insulin sensitivity index calculated from a frequentlysampledintravenousglucosetolerancetest‐Si9.60[10 ‐5 (min ∗ pmol/L) ‐1 ] (8.23‐10.97)vs.11.79(10.41‐13.18),p=0.02‐inadulthoodcomparedtooffspring with birthweights in the upper tertile. Conclusions. Offspring with a family history of maternal T2DM have higher birthweights than those with paternal T2DM. Low birthweight associates with elevated plasma glucose levels after an oral glucose load and decreased insulin sensitivity in adulthood. Abbreviations: AIR, acute serum insulin responses; AUC, area under the curve; BMI, body mass index; FSIGT, frequently sampled intravenous glucose tolerance test;OGTT,oralglucosetolerancetest;Sg,glucoseeffectiveness;Si,insulinsensitivity index; T2DM, type 2 diabetes
Published: 2011

18. High Prevalence of Type 2 Diabetes and Pre-Diabetes in Adult Offspring of Women With Gestational Diabetes Mellitus or Type 1 Diabetes

Author: Tine D. Clausen, Dorte Møller Jensen, Peter Damm, Torben Hansen, Oluf Pedersen, Jeannet Lauenborg, and Elisabeth R. Mathiesen
Subjects: Advanced and Specialized Nursing, medicine.medical_specialty, Type 1 diabetes, Glucose tolerance test, medicine.diagnostic_test, business.industry, Offspring, Endocrinology, Diabetes and Metabolism, Physiology, Type 2 diabetes, medicine.disease, Impaired fasting glucose, Gestational diabetes, Impaired glucose tolerance, Endocrinology, Internal medicine, Diabetes mellitus, Internal Medicine, medicine, business
Abstract: OBJECTIVE—The role of intrauterine hyperglycemia and future risk of type 2 diabetes in human offspring is debated. We studied glucose tolerance in adult offspring of women with either gestational diabetes mellitus (GDM) or type 1 diabetes, taking the impact of both intrauterine hyperglycemia and genetic predisposition to type 2 diabetes into account. RESEARCH DESIGN AND METHODS—The glucose tolerance status following a 2-h 75-g oral glucose tolerance test (OGTT) was evaluated in 597 subjects, primarily Caucasians, aged 18–27 years. They were subdivided into four groups according to maternal glucose metabolism during pregnancy and genetic predisposition to type 2 diabetes: 1) offspring of women with diet-treated GDM (O-GDM), 2) offspring of genetically predisposed women with a normal OGTT (O-NoGDM), 3) offspring of women with type 1 diabetes (O-type 1), and 4) offspring of women from the background population (O-BP). RESULTS—The prevalence of type 2 diabetes and pre-diabetes (impaired glucose tolerance or impaired fasting glucose) in the four groups was 21, 12, 11, and 4%, respectively. In multiple logistic regression analysis, the adjusted odds ratios (ORs) for type 2 diabetes/pre-diabetes were 7.76 (95% CI 2.58–23.39) in O-GDM and 4.02 (1.31–12.33) in O-type 1 compared with O-BP. In O-type 1, the risk of type 2 diabetes/pre-diabetes was significantly associated with elevated maternal blood glucose in late pregnancy: OR 1.41 (1.04–1.91) per mmol/l. CONCLUSIONS—A hyperglycemic intrauterine environment appears to be involved in the pathogenesis of type 2 diabetes/pre-diabetes in adult offspring of primarily Caucasian women with either diet-treated GDM or type 1 diabetes during pregnancy.
Published: 2008

19. Pre-emptive treatment with fibrinogen concentrate for postpartum haemorrhage: randomized controlled trial

Author: Kim Ekelund, Volker Classen, Birgit Bødker, Jens Svare, Benedicte Utke Ramsing, Louise Pedersen, A. Afshari, L. Fuhrmann, Christian Viggo Nielsen, Lone Fuhrmann, H.F. Sharif, J. Svare, A.U. Mitchell, Jens Lunde, Marina K. Christensen, A. Troelstrup, Marianne S. Flindt, Christine Andersen, Lars Hyldborg Lundstrøm, Casper Okkels, Erik L. Secher, H.M. Edwards, Iben Darfeld, Marie Søgaard, Anna Engskov, Ane Troelstrup, Anja U. Mitchell, G. Hanke, Anne Wikkelsø, Rasmus Berthelsen, Peter Jensen-Gadegaard, K. Ekelund, Karen Elisabeth Linnet, Heidi F Sharif, A.J. Wikkelsø, Maria Petersen, A.M. Møller, L.M. Pedersen, Jakob Stensballe, Gabriele Hanke, Ann Merete Møller, Kristian J. Andersen, J. Lauenborg, M. H. Madsen, J. Langhoff-Roos, J. Stensballe, Jens Langhoff-Roos, B. Bødker, C. B. Wulff, Rasmus Winkel, Pernille Opstrup, Mette Andersson, Mathias Johansen, Birgit Lassen, Arash Afshari, Marie Winther-Olsen, E.L. Secher, Hellen Mc Kinnon Edwards, M.G. Madsen, Michelé Lefort Sønderskov, Sine Hougaard, Lars Møller Pedersen, Jeannet Lauenborg, Line Stendall, Charlotte Albrechtsen, C. Albrechtsen, Mette G. Madsen, and Marianne Berntsen
Subjects: Blood transfusion, medicine.medical_treatment, Placebo, Fibrinogen, law.invention, Randomized controlled trial, Double-Blind Method, law, Pregnancy, medicine, Humans, Hemostasis, business.industry, Postpartum Hemorrhage, Liter, medicine.disease, Anesthesiology and Pain Medicine, Treatment Outcome, Anesthesia, Maternal death, Female, business, Erythrocyte Transfusion, Postpartum period, medicine.drug
Abstract: Background. In early postpartum haemorrhage (PPH), a low concentration of fibrinogen is associated with excessive subsequent bleeding and blood transfusion. We hypothesized that pre-emptive treatment with fibrinogen concentrate reduces the need for red blood cell (RBC) transfusion in patients with PPH. Methods. In this investigator-initiated, multicentre, double-blinded, parallel randomized controlled trial, we assigned subjects with severe PPH to a single dose of fibrinogen concentrate or placebo (saline). A dose of 2 g or equivalent was given to all subjects independent of body weight and the fibrinogen concentration at inclusion. The primary outcome was RBC transfusion up to 6 weeks postpartum. Secondary outcomes were total blood loss, total amount of blood transfused, occurrence of rebleeding, haemoglobin ,58 g litre 21 , RBC transfusion within 4 h, 24 h, and 7 days, and as a composite outcome of ‘severe PPH’, defined as a decrease in haemoglobin of .40 g litre 21 , transfusion of at least 4 units of RBCs, haemostatic intervention (angiographic embolization, surgical arterial ligation, or hysterectomy), or maternal death. Results. Of the 249 randomized subjects, 123 of 124 in the fibrinogen group and 121 of 125 in the placebo group were included in the intention-to-treat analysis. At inclusion the subjects had severe PPH, with a mean blood loss of 1459 (SD 476) ml and a mean fibrinogen concentration of 4.5 (SD 1.2) g litre 21 . The intervention group received a mean dose of 26 mg kg 21 fibrinogen concentrate, thereby significantly increasing fibrinogen concentration compared with placebo by 0.40 g litre 21 (95% confidence interval, 0.15 –0.65; P¼0.002). Postpartum blood transfusion occurred in 25 (20%) of the fibrinogen group and 26 (22%) of the placebo group (relative risk, 0.95; 95% confidence interval, 0.58 –1.54; P¼0.88). We found no difference in any predefined secondary outcomes, per-protocol analyses, or adjusted analyses. No thromboembolic events were detected. Conclusions. We found no evidence for the use of 2 g fibrinogen concentrate as pre-emptive treatment for severe PPH in patients with normofibrinogenaemia. Clinical trial registration. ClinicalTrials.gov: http://clinicaltrials.gov/show/NCT01359878. Published protocol: http://www.trialsjournal.com/content/pdf/1745-6215-13-110.pdf.
Published: 2015

20. The Prevalence of the Metabolic Syndrome in a Danish Population of Women with Previous Gestational Diabetes Mellitus Is Three-Fold Higher than in the General Population

Author: Torben Jørgensen, Oluf Pedersen, Peter J. Hornnes, Knut Borch-Johnsen, Torben Hansen, Peter Damm, Jeannet Lauenborg, Charlotte Glümer, and Elisabeth R. Mathiesen
Subjects: Adult, medicine.medical_specialty, Endocrinology, Diabetes and Metabolism, Clinical Biochemistry, Population, Biochemistry, Endocrinology, Insulin resistance, Pregnancy, Internal medicine, Diabetes mellitus, Prevalence, medicine, Humans, education, National Cholesterol Education Program, Metabolic Syndrome, education.field_of_study, business.industry, Biochemistry (medical), Middle Aged, medicine.disease, Obesity, Gestational diabetes, Diabetes, Gestational, Female, Metabolic syndrome, business
Abstract: Context: Diabetes and obesity, components of the metabolic syndrome, are common characteristics of women with prior gestational diabetes mellitus (GDM). Due to increasing incidence of diabetes and obesity, the metabolic syndrome might comprise a major health problem among these women. Objective: The objective was to estimate the prevalence of the metabolic syndrome by three different criteria [World Health Organization 1999 (WHO), The National Cholesterol Education Program Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults 2001, and European Group for the Study of Insulin Resistance 2002] among women with previous GDM. Design: We conducted a follow-up study of a Danish cohort of women admitted in 1978–1996 to the Diabetes and Pregnancy Center, Rigshospitalet, Copenhagen University Hospital, with diet-treated GDM. The follow-up took place in 2000–2002 at median 9.8 yr (interquartile range 6.4–17.2) after pregnancy. Results were compared with a control group of 1000 age-matched women from a population-based sample (Inter99). Participants: Four hundred eighty-one women at median age 43 yr (interquartile range 38–48) participated. Main Outcome Measures: The main outcome measures were body mass index (BMI), glucose tolerance, blood pressure, lipid profile, and insulin resistance. Results: Independent of the criteria, the prevalence of the metabolic syndrome was three times higher in the prior GDM group, compared with the control group (e.g. WHO: 38.4 vs. 13.4%, P < 0.0005). Age- and BMI-adjusted odds ratio for having the WHO-defined metabolic syndrome was 3.4 (95% confidence interval 2.5–4.8) for the prior GDM group vs. the control group. Obese women (BMI > 30 kg/m2) with previous GDM had a more than 7-fold increased prevalence of the metabolic syndrome (WHO), compared with normal-weight prior GDM women (BMI < 25 kg/m2). In glucose-tolerant women, the prevalence was doubled in the prior GDM group, compared with control group. Conclusion: The prevalence of the metabolic syndrome was three times as high in women with prior diet-treated GDM, compared with age-matched control subjects.
Published: 2005

21. Increasing Incidence of Diabetes After Gestational Diabetes

Author: Lars Mølsted-Pedersen, Torben Hansen, Henning Locht, Peter J. Hornnes, Jeannet Lauenborg, Oluf Pedesen, Peter Damm, Henrik Vestergaard, and Dorte Møller Jensen
Subjects: medicine.medical_specialty, Pediatrics, Endocrinology, Diabetes and Metabolism, Type 2 diabetes, Overweight, Impaired glucose tolerance, Diabetes mellitus, Internal medicine, Internal Medicine, medicine, Advanced and Specialized Nursing, Glucose tolerance test, medicine.diagnostic_test, business.industry, Obstetrics and Gynecology, nutritional and metabolic diseases, General Medicine, Impaired fasting glucose, medicine.disease, Gestational diabetes, Endocrinology, Cohort, medicine.symptom, business, Postpartum period, Cohort study
Abstract: Women with gestational diabetes mellitus (GDM) are known to be at increased risk of having overt diabetes, especially type 2 diabetes, later in life. Most long-term studies, however, involved non-European populations and did not distinguish between dietary and insulin treatment. The investigators determined the long-term risk of diabetes in Danish women having diet-treated GDM. An "old" cohort of 241 women presented in 1978-1985 and followed up for 2 to 11 years. A "new" cohort of 512 women presented at the same center in 1987-1996 and were reassessed in 2000-2002. The oral glucose tolerance test, done using 50 or 75 g of glucose, was read as abnormal if at least 2 of 7 blood glucose values exceeded 3 standard deviations above the mean for nonpregnant women. A total of 481 women, nearly two thirds of the total, were followed up a median of 9.8 years after the index pregnancy. Diabetes was present at follow up in 40% of women and impaired glucose tolerance or impaired fasting glucose in 27%. Type 2 diabetes was diagnosed in 171 of 192 patients affected. All 12 women with overt diabetes in the postpartum period had diabetes at follow up. The incidence of diabetes was more than 2-fold higher in the new cohort than in the old one in 1990, but rates were similar at follow up in 2002. On multiple logistic regression analysis, diabetes was independently associated with being in the new cohort, overweight or obesity before pregnancy, an early diagnosis of GDM, a high fasting glucose at the time of oral glucose tolerance testing, and impaired glucose tolerance in the postpartum period. This study demonstrated a doubling in the incidence of diabetes and impaired glucose tolerance or impaired fasting glucose over a 10-year period in women having diet-treated GDM. Prepregnancy obesity further increased the risk, suggesting that timely intervention might prevent or delay the development of overt diabetes.
Published: 2004

22. Screening for Gestational Diabetes

Author: Peter J. Hornnes and Jeannet Lauenborg
Subjects: medicine.medical_specialty, business.industry, Obstetrics, Overweight, medicine.disease, Asymptomatic, Obesity, Gestational diabetes, Increased risk, Diabetes mellitus, General screening, Health care, Medicine, medicine.symptom, business
Abstract: Gestational diabetes is an asymptomatic condition associated with adverse outcome for mother and child. Overweight and obesity confer a higher risk of gestational diabetes – up to 11-fold. Health care providers of pregnant women should ensure that a strategy for screening gestational diabetes is in place. Either general screening programmes or selective screening programmes may be employed. Women with gestational diabetes should be monitored and treated vigorously. After delivery, glucose metabolism is most often normalised, but women with previous gestational diabetes have an increased risk of developing type-2 diabetes in later years. Therefore, they should be counselled about healthy lifestyles and offered exanimations for diabetes or pre-diabetes with 1–3 year intervals.
Published: 2013

23. The risk of adverse pregnancy outcome after bariatric surgery: a nationwide register-based matched cohort study

Author: Mette Mandrup Kjær, Jeannet Lauenborg, Birger Michael Breum, and Lisbeth Nilas
Subjects: Adult, medicine.medical_specialty, Birth weight, Denmark, Bariatric Surgery, Gestational Age, Lower risk, Risk Assessment, Cohort Studies, Pregnancy, medicine, Birth Weight, Humans, Obesity, Registries, Obstetrics, business.industry, Case-control study, Infant, Newborn, Pregnancy Outcome, Obstetrics and Gynecology, Gestational age, medicine.disease, Surgery, Pregnancy Complications, Case-Control Studies, Infant, Small for Gestational Age, Small for gestational age, Female, business, Body mass index, Cohort study
Abstract: The aim of this study was to describe the risk of adverse obstetric and neonatal outcome after bariatric surgery.Nationwide register-based matched cohort study of singleton deliveries after bariatric surgery during 2004-2010. Data were extracted from The Danish National Patient Registry and The Medical Birth Register. Each woman with bariatric surgery (exposed) was individually matched with 4 women without bariatric surgery (unexposed) on body mass index, age, parity, and date of delivery. Continuous variables were analyzed with the paired t test and binary outcomes were analyzed by logistic regression.We identified 339 women with a singleton delivery after bariatric surgery (84.4% gastric bypass). They were matched to 1277 unexposed women. Infants in the exposed group had shorter mean gestational age (274 vs 278 days; P.001), lower mean birthweight (3312 vs 3585 g; P.001), lower risk of being large for gestational age (adjusted odds ratio, 0.31; 95% confidence interval, 0.15-0.65), and higher risk of being small for gestational age (SGA) (adjusted odds ratio, 2.29; 95% confidence interval, 1.32-3.96) compared with infants in the unexposed group. No statistically significant difference was found between the groups regarding the risk of gestational diabetes mellitus, preeclampsia, labor induction, cesarean section, postpartum hemorrhage, Apgar score less than 7, admission to neonatal intensive care unit or perinatal death.Infants born after maternal bariatric surgery have lower birthweight, lower gestational age, 3.3-times lower risk of large for gestational age, and 2.3-times higher risk of SGA than infants born by a matched group of women without bariatric surgery. The impact on SGA was even higher in the subgroup with gastric bypass.
Published: 2012

24. The FIB-PPH trial: fibrinogen concentrate as initial treatment for postpartum haemorrhage: study protocol for a randomised controlled trial

Author: Gabriele Hanke, Arash Afshari, Kim Ekelund, Jens Svare, Jens Langhoff-Roos, Mette Gøttge Madsen, Heidi Sharif, Birgit Bødker, Lars Møller Pedersen, Jeannet Lauenborg, Anne Juul Wikkelsoe, Charlotte Krebs Albrechtsen, Ane Troelstrup, Jakob Stensballe, Ann Merete Møller, and Anja U Mitchell
Subjects: medicine.medical_specialty, Time Factors, Blood transfusion, Denmark, medicine.medical_treatment, Medicine (miscellaneous), Fibrinogen, Hemostatics, Postpartum haemorrhage, law.invention, Study Protocol, Double-Blind Method, Randomized controlled trial, Predictive Value of Tests, Pregnancy, law, medicine, Coagulation testing, Humans, Pharmacology (medical), Blood coagulation test, Blood type, lcsh:R5-920, Coagulation, medicine.diagnostic_test, Obstetrics, business.industry, Postpartum Hemorrhage, Perioperative, Thromboelastography, Thrombelastography, Surgery, Treatment Outcome, Research Design, Fibrinogen concentrate, Female, Blood Coagulation Tests, lcsh:Medicine (General), business, Haemostasis, medicine.drug
Abstract: Background Postpartum haemorrhage (PPH) remains a leading cause of maternal mortality worldwide. In Denmark 2% of parturients receive blood transfusion. During the course of bleeding fibrinogen (coagulation factor I) may be depleted and fall to critically low levels, impairing haemostasis and thus worsening the ongoing bleeding. A plasma level of fibrinogen below 2 g/L in the early phase of postpartum haemorrhage is associated with subsequent development of severe haemorrhage. Use of fibrinogen concentrate allows high-dose substitution without the need for blood type crossmatch. So far no publications of randomised controlled trials involving acutely bleeding patients in the obstetrical setting have been published. This trial aims to investigate if early treatment with fibrinogen concentrate reduces the need for blood transfusion in women suffering severe PPH. Methods/Design In this randomised placebo-controlled double-blind multicentre trial, parturients with primary PPH are eligible following vaginal delivery in case of: manual removal of placenta (blood loss ≥ 500 ml) or manual exploration of the uterus after the birth of placenta (blood loss ≥ 1000 ml). Caesarean sections are also eligible in case of perioperative blood loss ≥ 1000 ml. The exclusion criteria are known inherited haemostatic deficiencies, prepartum treatment with antithrombotics, pre-pregnancy weight Primary outcome is the need for blood transfusion. To investigate a 33% reduction in the need for blood transfusion, a total of 245 patients will be included. Four university-affiliated public tertiary care hospitals will include patients during a two-year period. Adverse events including thrombosis are assessed in accordance with International Conference on Harmonisation (ICH) good clinical practice (GCP). Discussion A widespread belief in the benefits of early fibrinogen substitution in cases of PPH has led to increased off-label use. The FIB-PPH trial is investigator-initiated and aims to provide an evidence-based platform for the recommendations of the early use of fibrinogen concentrate in PPH. Trial registration ClincialTrials.gov NCT01359878.
Published: 2012

25. Further evidence that mutations in INS can be a rare cause of Maturity-Onset Diabetes of the Young (MODY)

Author: Ondrej Cinek, Trine Welløv Boesgaard, Peter Damm, Jan Lebl, Jeannet Lauenborg, Flemming Pociot, Fabrizio Barbetti, Stepanka Pruhova, Torben Hansen, Charlotta Pisinger, Regine Bergholdt, Barbora Obermannova, Oluf Pedersen, and Ehm A. Andersson
Subjects: Proband, Male, lcsh:Internal medicine, medicine.medical_specialty, Pediatrics, lcsh:QH426-470, medicine.medical_treatment, Population, Maturity onset diabetes of the young, Young Adult, Mutation Carrier, Pregnancy, Diabetes mellitus, Internal medicine, Genetics, Medicine, Humans, Insulin, Genetics(clinical), Young adult, lcsh:RC31-1245, education, Genetics (clinical), education.field_of_study, business.industry, Genetic Variation, medicine.disease, Pedigree, Gestational diabetes, lcsh:Genetics, Diabetes, Gestational, Endocrinology, Diabetes Mellitus, Type 1, Phenotype, Diabetes Mellitus, Type 2, Mutation, Female, business, Research Article
Abstract: Background Insulin gene (INS) mutations have recently been described as a common cause of permanent neonatal diabetes (PNDM) and a rare cause of diabetes diagnosed in childhood or adulthood. Methods INS was sequenced in 116 maturity-onset diabetes of the young (MODYX) patients (n = 48 Danish and n = 68 Czech), 83 patients with gestational diabetes mellitus (GDM), 34 type 1 diabetic patients screened negative for glutamic acid decarboxylase (GAD), and 96 glucose tolerant individuals. The control group was randomly selected from the population-based sampled Inter99 study. Results One novel heterozygous mutation c.17G>A, R6H, was identified in the pre-proinsulin gene (INS) in a Danish MODYX family. The proband was diagnosed at 20 years of age with mild diabetes and treated with diet and oral hypoglycaemic agent. Two other family members who carried the INS R6H were diagnosed with diabetes when 51 years old and with GDM when 27 years old, respectively. A fourth mutation carrier had normal glucose tolerance when 20 years old. Two carriers of INS R6H were also examined twice with an oral glucose tolerance test (OGTT) with 5 years interval. They both had a ~30% reduction in beta-cell function measured as insulinogenic index. In a Czech MODYX family a previously described R46Q mutation was found. The proband was diagnosed at 13 years of age and had been treated with insulin since onset of diabetes. Her mother and grandmother were diagnosed at 14 and 35 years of age, respectively, and were treated with oral hypoglycaemic agents and/or insulin. Conclusion Mutations in INS can be a rare cause of MODY and we conclude that screening for mutations in INS should be recommended in MODYX patients.
Published: 2010

26. Overweight and the metabolic syndrome in adult offspring of women with diet-treated gestational diabetes mellitus or type 1 diabetes

Author: Tine D. Clausen, Lone Schmidt, Peter Damm, Dorte Møller Jensen, Oluf Pedersen, Torben Hansen, Jeannet Lauenborg, and Elisabeth R. Mathiesen
Subjects: Adult, Male, medicine.medical_specialty, Adolescent, Offspring, Endocrinology, Diabetes and Metabolism, Clinical Biochemistry, Population, Pregnancy in Diabetics, Overweight, Biochemistry, Cohort Studies, Young Adult, Endocrinology, Child of Impaired Parents, Pregnancy, Risk Factors, Internal medicine, Diabetes mellitus, medicine, Humans, education, Metabolic Syndrome, Type 1 diabetes, education.field_of_study, business.industry, Metabolic Syndrome X, Biochemistry (medical), nutritional and metabolic diseases, medicine.disease, Gestational diabetes, Diabetes, Gestational, Diabetes Mellitus, Type 1, Prenatal Exposure Delayed Effects, Adult Children, Female, Metabolic syndrome, medicine.symptom, business, Algorithms, Follow-Up Studies
Abstract: Udgivelsesdato: 2009-Jul CONTEXT: In animal studies, exposure to intrauterine hyperglycemia increases the risk of cardiovascular disease through only partly understood epigenetic mechanisms. Human long-term follow-up studies on the same topic are few. OBJECTIVE: The aim was to study the risk of overweight and the metabolic syndrome in adult offspring of women with diet-treated gestational diabetes mellitus (GDM) or type 1 diabetes, and additionally to study associations between estimates of maternal hyperglycemia and outcome in the offspring. DESIGN AND SETTING: We conducted a follow-up study of 1066 primarily Caucasian women aged 18-27 yr in the Center for Pregnant Women with Diabetes, Rigshospitalet, Copenhagen, Denmark. PARTICIPANTS: Offspring of women with diet-treated GDM (n = 168) and an unexposed reference group (n = 141) participated, as well as offspring of women with type 1 diabetes (n = 160) and offspring from the background population representing an unexposed reference group (n = 128). The follow-up rate was 56% (597 of 1066). MAIN OUTCOME MEASURES: Women with body mass index of at least 25 kg/m(2) were considered overweight. The metabolic syndrome was determined by the International Diabetes Federation 2006 criteria. Results: The risk of overweight was doubled in offspring of women with diet-treated GDM or type 1 diabetes compared with offspring from the background population, whereas the risk of the metabolic syndrome was 4- and 2.5-fold increased, respectively. Offspring risk of the metabolic syndrome increased significantly with increasing maternal fasting blood glucose as well as 2-h blood glucose (during oral glucose tolerance test). CONCLUSIONS: Adult offspring of women with diet-treated GDM or type 1 diabetes are risk groups for overweight and the metabolic syndrome. Intrauterine hyperglycemia may in addition to genetics and other factors contribute to the pathogenesis of overweight and the metabolic syndrome.
Published: 2009

27. Common type 2 diabetes risk gene variants associate with gestational diabetes

Author: Peter Damm, Torben Jørgensen, Jeannet Lauenborg, Torben Hansen, Oluf Pedersen, Niels Grarup, and Knut Borch-Johnsen
Subjects: Adult, Risk, medicine.medical_specialty, endocrine system diseases, Endocrinology, Diabetes and Metabolism, Clinical Biochemistry, Population, Type 2 diabetes, Biochemistry, Body Mass Index, Cohort Studies, Endocrinology, Gene Frequency, Pregnancy, Diabetes mellitus, Internal medicine, medicine, Humans, Genetic Predisposition to Disease, education, CDKAL1, education.field_of_study, SLC30A8, biology, business.industry, Biochemistry (medical), nutritional and metabolic diseases, Odds ratio, medicine.disease, Gestational diabetes, Diabetes, Gestational, Diabetes Mellitus, Type 2, ROC Curve, biology.protein, Female, business, TCF7L2
Abstract: Objective: We aimed to examine the association between gestational diabetes mellitus (GDM) and 11 recently identified type 2 diabetes susceptibility loci. Research Design and Methods: Type 2 diabetes risk variants in TCF7L2, CDKAL1, SLC30A8, HHEX/IDE, CDKN2A/2B, IGF2BP2, FTO, TCF2, PPARG, KCNJ11, and WFS1 loci were genotyped in a cohort of women with a history of GDM (n = 283) and glucose-tolerant women of the population-based Inter99 cohort (n = 2446). Results: All the risk alleles in the 11 examined type 2 diabetes risk variants showed an odds ratio (OR) greater than 1 for the GDM group compared with the control group ranging from 1.13 [95% confidence interval (CI) 0.88–1.46] to 1.44 (95% CI 1.19–1.74) except for the WFS1 rs10010131 variant with OR 0.87 (95% CI 0.73–1.05). Combined analysis of all 11 variants showed a highly significant additive effect of multiple risk alleles on risk of GDM [OR 1.18 (95% CI 1.10–1.27)] per risk allele, P = 3.2 × 10−6). Applying receiver-operating characteristic showed an area under the receiver-operating characteristic curve of 0.62 for the genetic test alone and 0.73 when combining information on age, body mass index, and genotypes of the 11 gene variants. Conclusions: The prevalence in a prior GDM group of several previously proven type 2 diabetes risk alleles equals the findings from association studies on type 2 diabetes. This supports the hypothesis that GDM and type 2 diabetes are two of the same entity.
Published: 2008

28. Diabetes mellitus and the metabolic syndrome after gestational diabetes

Author: Peter Damm, Lars Mølsted-Pedersen, Jeannet Lauenborg, and Elisabeth R. Mathiesen
Subjects: Gestational diabetes, Pediatrics, medicine.medical_specialty, business.industry, Diabetes mellitus, medicine, Metabolic syndrome, medicine.disease, business
Published: 2008

29. 40(th) EASD Annual Meeting of the European Association for the Study of Diabetes : Munich, Germany, 5-9 September 2004

Author: S. Artigas, A V Dreval, Mark I. McCarthy, C Watson, Peter H. Bennett, M Quint, Y Ikeda, E Alpert, F Schiele, H Sekihara, Erik Gylfe, P Lowe, J Kuhlmann, Alain Golay, V Longo, Shahidul Alam Khan Akm., L G Mantovani, M Zawodniak-Szalapska, G Winkler, T Harrity, L Virág, U Johne, Kuo S-W., Linda C Tapsell, J Rodriguez, Michel Komajda, K Kankova, Carole A. Cull, M Sporna, E Estilles, U Ribel, M C Spruce, E Buzzigoli, T Prazak, J K McLaughlin, M K Lingohr, M Lim, F Calara, A Siebenhofer, G Meregalli, Roberto Anichini, A D Baron, R Kurashvili, P C Butler, G I Fantus, T. E. De Gooyer, Park Y-M., R. Walther, S Heinrich, Agnieszka Zawiejska, S Mukherjee, Nikolaos Papanas, G Wong, Ian D. Caterson, David M. Maahs, Shuichi Kaneko, Alexandra E. Butler, Francisco Javier Ampudia-Blasco, O N Kong, Attali J-R., C A Hedman, K Oshinyemi, Nicolle Müller, I C Cranston, N Okumus, M V Vlaiculescu, Balasubramanian Ravikumar, W W Cheatham, K Mukasa, K B Biswas, Annunziata Lapolla, Phil McEwan, G Mader, Gilles Chassot, Dragi Anevski, Werner A. Scherbaum, M Donath, C Hesselmann, R A Gandhi, David E. Moller, Ezio Bonifacio, C Garcia, V Ifandi, P Hornnes, Nieuwenhoven Fav., C Puech, S Pérez-Del-Pulgar, Kim S-R., G Hines, C Rubio Terrés, Michael Gaster, N. Hosszufalusi, A Scholze, Andrew A. Young, Stavros Liatis, F Hariri, S Tan, Paul Valensi, Allan E. Karlsen, J Kim, E. Moberg, J Kaiser, L Berman, G Nelson, A Altkrüger, P Kothare, D B Cook, S Doran, G. van Dijk, Shahnaz Shahinfar, Kim C-S., P Stahl, M Manousaki, S Sigrist, S K Lim, M. P. Stern, A Guberti, C Rezzani, J McKenney, Karl Thomaseth, Sofia Carlsson, M Julia, R Brillante, I Rubesova, T Darkow, E Matsumoto, Wendy M. Macfarlane, M Di Martino, G Bardini, Rossella Menghini, D Duhot, E Farcasiu, Annalisa Natalicchio, I Lindner, J Buvat, Christian L. Brand, Harry Dorchy, Iwona Pietrzak, Z T Luo, P Home, M Ekelund, Jesper Gromada, Kristine Færch, F Piarulli, H Kim, R Mentel, Zsuzsanna K. Zsengellér, Dullaart Rpf., Anton Luger, Thomas A. Pearson, V Manicardi, P Rösen, Feng Y-M., R Morganti, Lars Hansen, Demuth H-U., Haruo Kasai, A Shostak, Rudi Steffensen, G Taylor, Markolf Hanefeld, C Santini, E Hamaguchi, Roberto Miccoli, F Storms, M Cooper, Y Lee, Allison E. Aiello, P Smith, T Suehiro, K Treece, M Waluś, Timothy A Welborn, Simone Baltrusch, E Kontela, S Chai, J Crean, H Yokoyama, Johan G. Eriksson, Rafael Hernández Hernández, J Rodríguez-Saldaña, M P Tornero, G Formoso, D. Lovell, E Bingham, A Mylonakis, M Manteghetti, D Fedele, Antonio Martín-Duce, Ralph A. DeFronzo, D Salcedo, Kurt Højlund, Antonio Petrone, Sheu Whh., C Gutierrez, Flavia Pricci, S Kurita, Z G Abbas, M M Benedetti, Philippe A. Halban, Daniel J. Cox, O Ljungkvist, Justine Davies, J Palsgaard, Lars Sjöström, E Bosi, L Janin-Manificat, W. F. Kelly, M. Fernandez, E Colak, O V Mulyarchik, B Kronshage, F Lang, M Erfurth, Takashi Kadowaki, N Jendrike, U Walter, J Wishart, Y. Neye, D Kim, N Furuhashi, M Barsotti, D Florow, L Ke, L Borgquist, N C Jackson, Ffolliott M. Fisher, V Baskar, K Yoshioka, Bryan A. Wolf, G Chabrier, R Skoumal, Livio Luzi, H Kose, I Pharisien, B. Klein, H Winiarska, M C Johnson, L Griffiths, Nonna Kravchun, C Combe, Baptist Gallwitz, J Zdychova, L Skorda, Jorma Ilonen, W Gao, I N Steen, A Terrinoni, P D Ambery, W Kern, C M Kusminski, Cho M-H., Paolo Pozzilli, Louise G. Grunnet, E Schönle, David R Matthews, Robert W. Taylor, Y Cohen, Kim H-S., M P Eccles, N B Tutuncu, D McDowell, Richard M. Bergenstal, K Takamatsu, T Steiner, Jaan Palgi, Valdemar Grill, N Niculescu, G Federici, S Lehto, P. M. McKeigue, M Barone, Michael E. 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Dell'Antonio, G, Maestroni, A, Ruggieri, D, Luzi, L, Piemonti, L, Zerbini, G, Anafaroglu, I, Tutuncu, N, Sultana, M, Siddiqua, N, Iwasaki, T, Nakajima, A, Yoneda, M, Mukasa, K, Tanaka, S, and Sekihara, H
Subjects: 0303 health sciences, medicine.medical_specialty, business.industry, EASD, Endocrinology, Diabetes and Metabolism, Human physiology, medicine.disease, 03 medical and health sciences, 0302 clinical medicine, Diabetes mellitus, Family medicine, Internal Medicine, Medicine, business, 030217 neurology & neurosurgery, 030304 developmental biology
Published: 2004

30. Audit on stillbirths in women with pregestational type 1 diabetes

Author: Jes G. Westergaard, Elisabeth R. Mathiesen, Peter Damm, Per Ovesen, Pia Ekbom, Jeannet Lauenborg, and Lars Mølsted-Pedersen
Subjects: medicine.medical_specialty, Endocrinology, Diabetes and Metabolism, Pregnancy, Diabetes mellitus, Internal Medicine, medicine, Humans, reproductive and urinary physiology, Glycemic, Retrospective Studies, Advanced and Specialized Nursing, Hemoglobin A, Glycosylated, Glycated Hemoglobin, Type 1 diabetes, Medical Audit, business.industry, Obstetrics, Incidence (epidemiology), Infant, Newborn, Pregnancy Outcome, Retrospective cohort study, medicine.disease, female genital diseases and pregnancy complications, Surgery, Diabetes, Gestational, Diabetes Mellitus, Type 1, Etiology, Gestation, Female, business
Abstract: OBJECTIVE—To audit stillbirth cases in women with type 1 diabetes to search for specific characteristics in order to improve antenatal care and treatment RESEARCH DESIGN AND METHODS—Retrospectively identified cases of stillbirths in women with type 1 diabetes during 1990–2000 were analyzed regarding characteristics of the mother, the pregnancy, glycemic control, and the stillborn. The cause of stillbirth was categorized as explainable, likely, or without obvious cause. RESULTS—We found 22 women with 25 stillbirths among 1,361 singleton births by women with type 1 diabetes. In seven stillbirths the cause was categorized as explainable and in six as likely. In 12 cases no obvious cause was found; however, glycemic control was suboptimal in 9 of these cases. A total of 14 women reported daily smoking, and 10 of 19 with low education were unemployed. CONCLUSIONS—Women experiencing stillbirth were characterized by a high incidence of suboptimal glycemic control, diabetic nephropathy, smoking, and low social status.
Published: 2003

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30 results on '"Jeannet Lauenborg"'

1. A flexible silicone patch for treatment of hemorrhoids after birth: a pilot study of HEMOCIN® Patch

2. Screening for Gestational Diabetes Mellitus and Care of Diabetes Mellitus in Pregnancy

3. Validity of bladder volume measurement by ultrasound in women postpartum

4. Changing incidence of obstetric anal sphincter injuries—A result of formal prevention programs?

5. The increasing role of a retained placenta in postpartum blood loss: a cohort study

6. Comparative Studies of the Gut Microbiota in the Offspring of Mothers With and Without Gestational Diabetes

7. Gestational diabetes and the human salivary microbiota: a longitudinal study during pregnancy and postpartum

8. Newborn body composition after maternal bariatric surgery

9. Maternal Long-Term Outcomes after a Pregnancy Complicated by Gestational Diabetes Mellitus

10. The incidence of obstetric anal sphincter injury depends on both correct diagnosis and preventive strategies

11. Continuous focus on preventive strategies and follow up is important for a change

12. Gestational diabetes mellitus and long-term consequences for mother and offspring: a view from Denmark

13. A Time Interval of More Than 18 Months Between a Pregnancy and a Roux-en-Y Gastric Bypass Increases the Risk of Iron Deficiency and Anaemia in Pregnancy

14. Ponderal index at birth associates with later risk of gestational diabetes mellitus

15. High Prevalence of Diabetes-Predisposing Variants in MODY Genes Among Danish Women With Gestational Diabetes Mellitus

16. The Impact of Upper Abdominal Pain During Pregnancy Following a Gastric Bypass

17. The influence of parental history of diabetes and offspring birthweight on offspring glucose metabolism in adulthood

18. High Prevalence of Type 2 Diabetes and Pre-Diabetes in Adult Offspring of Women With Gestational Diabetes Mellitus or Type 1 Diabetes

19. Pre-emptive treatment with fibrinogen concentrate for postpartum haemorrhage: randomized controlled trial

20. The Prevalence of the Metabolic Syndrome in a Danish Population of Women with Previous Gestational Diabetes Mellitus Is Three-Fold Higher than in the General Population

21. Increasing Incidence of Diabetes After Gestational Diabetes

22. Screening for Gestational Diabetes

23. The risk of adverse pregnancy outcome after bariatric surgery: a nationwide register-based matched cohort study

24. The FIB-PPH trial: fibrinogen concentrate as initial treatment for postpartum haemorrhage: study protocol for a randomised controlled trial

25. Further evidence that mutations in INS can be a rare cause of Maturity-Onset Diabetes of the Young (MODY)

26. Overweight and the metabolic syndrome in adult offspring of women with diet-treated gestational diabetes mellitus or type 1 diabetes

27. Common type 2 diabetes risk gene variants associate with gestational diabetes

28. Diabetes mellitus and the metabolic syndrome after gestational diabetes

29. 40(th) EASD Annual Meeting of the European Association for the Study of Diabetes : Munich, Germany, 5-9 September 2004

30. Audit on stillbirths in women with pregestational type 1 diabetes

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30 results on '"Jeannet Lauenborg"'

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