Search

Psychological disturbance (PD) or cerebral dysfunction (CD) covers several clinical areas, and has defining features of mental retardation. Recently, we conducted a study to investigate heritable heterogeneity in Pakistani consanguineous couples with recessive autosomal intellectual abnormalities. A cohort of three consanguineous families with multiple birth defects, belonging two to district lower Dir and one to district Lodhra, were selected for molecular analysis. All the affected individuals in the cohort showed autosomal recessive non-syndromic mental disturbances. DNA was extracted and subjected to Single tagged sequence (STS) marker analyses to all known non-syndromic autosomal recessive mental retardation (NS-ARMR) genes, while autozygosity mapping was performed by advanced SNP techniques. Fragment analyses of the NS-ARMR disease genes CRBN, CC2D2A, PRSS12, GRIK2, TUSC3, and CC2D1A using polymorphic STS markers confirmed these to be contender genes for the alteration. Mapping of autozygosity in all the study subjects using genome study revealed nine novel linkage intervals, i.e. four intervals for MR4, two intervals for MR8 and three intervals for MR13. In spite of being a monogenic condition, autosomal recessive mental retardation shows genetic heterogeneity and several genes are involved in different families; hence, there is a chance for involvement of separate gene in each family.

The question of how to govern and manage transboundary river basin for competing and often conflicting demands due to limited supplies continues to be an issue of concern, conflict, and cooperation. A key novelty of this paper is the use of the Water Diplomacy Framework (WDF) to address supply-demand mismatch using the notion of collaborative problem-solving and joint fact-finding. It builds on innovative applications of game-theoretic approaches and uses equity and sustainability as guiding principles to address the supply-demand mismatch. Five different bankruptcy methods (net benefit ranges between US$17,462M to US$18,201M) and the Nash Bargaining Solution (net benefit ranges between US$18,132M to US$19,216M) are used to resolve supply-demand mismatch in the Indus basin among four provinces within Pakistan. The maximum total benefit generated from the Nash Bargaining Solution is 5.5% higher compared to the best bankruptcy method. Moving from the non-cooperative and rule-based bankruptcy methods to the Nash Bargaining Solutions provided increased benefit for all stakeholders. Reallocation of these increased benefits among the four provinces is done by applying the Nash Bargaining Solutions for homogenous and heterogeneous weights. These findings suggest that aspects of WDF – cooperative problem-solving approaches involving joint fact-finding and exploring different options – has the potential to simultaneously resolve supply-demand mismatch and generate more benefits for all stakeholders.

Inhabited by almost 20 million people, Karachi, also known as the “city of lights”, houses almost 60 percent of the industries in Pakistan and is considered as the financial and industrial center of the country. The city contributes almost 12–15 percent to the gross domestic product (GDP), showing its significance in Pakistan’s economy. Unfortunately, with the increase in population, the city is facing a serious shortage of water supply. The current allocation of water among the city’s districts is not equitable, which has caused water scarcity and even riots in some areas. Surface water and ground water are the two primary sources of water supply in the city. The water supply provided by Karachi Water and Sewerage Board (KWSB) is approximately 650 million gallons per day (MGD) against a demand of 480–866 million gallons per day (MGD), resulting in a serious shortfall. Keeping a holistic view in mind, this paper focuses specifically on proposing measures to address the gap in proposing concrete solutions to manage Karachi’s increasing water woes. It also proposes a water allocation mechanism and uses Nash bargaining theory to address the inefficient and unequal water distribution. Results indicate that our suggested policies and water allocation mechanism have the potential to simultaneously resolve the supply–demand mismatch and water shortage problems of the city.

Introduction: Parkinson’s disease is the second most common neurodegenerative disease. The disease is more prevalent in aged individuals compared to young ones. Aim: The present study aimed to investigate the factors associated with PD in the population of Khyber Pakhtunkhwa, Pakistan. Methods: In this study, the questionnaire was filled from 600 PD patients, which include 54 familial cases, and 1,200 control subjects. To study the risk of PD in familial cases, questionnaires were also filled from the cases and controls. Results: This study revealed that depression symptomology is common in PD patients. Moreover, the risk of PD was higher in patients with consanguineous marriages compare to controls (OR = 3.96, 95% Cl = 1.98–7.89). The first-degree relatives (59.3%) of PD patients are more likely to develop PD compared to a second- (29.5%) or third-degree (11.1%) relatives. Furthermore, the risk of PD is higher in individuals whose parents get married to first-cousin (OR: 4.76, 95% Cl: 1.81–12.5) than second- (OR: 1.34, 95% Cl: 0.54–3.32) or third-cousin marriages (OR = 0.18, 95% Cl: 0.06–0.49). Moreover, the use of paracetamol (OR: 0.39; 95% Cl: 0.25–0.59) and ibuprofen (OR: 0.35; 95% Cl: 0.17–0.70) were higher in control subjects. Conclusion: This study concludes that consanguineous marriages and first-degree relation with PD patients increase the risk of PD, while the use of certain medications may decrease the risk of PD. Further study is warranted in a population of Pakistan.

The use of personal protective equipment (PPE) during cotton harvesting is critical for securing better health for female cotton pickers in the developing countries where health facilities are not sufficiently available to the masses in the rural areas. Despite increasing the efforts in increasing awareness about the benefits of PPE among the farm workers, a vast majority of the farm workers including pickers don't use the PPE. The present study examines health impacts of cotton harvesting in Pakistani Punjab along with the factors affecting the use of PPE among the cotton pickers. Cross-sectional data collected from Vehari district is used. The study estimates health cost and the use of PPE among the young and elder cotton pickers. Headache, sleeplessness, cough, flue/fever, skin and eyes problems are reported by the young and elder cotton pickers. Personal protective equipment is rarely used during picking. However, the young pickers relatively adopt more PPE compared to the elder cotton pickers. Health cost of cotton picking is US$2.96 and 3.06 per season during the year for the young and elder cotton pickers, respectively. Results of logit model show that health cost, age, education below 8th grade, perception of temporary impact and health problems are important determinants of adopting PPE among the cotton pickers. The findings of the study conclude that the use of PPE can be realized through proper training and education of cotton pickers and farm workers.

Rice is cultivated worldwide under wide range of ecological conditions and is a daily staple food crop for more than half of world’s population. The morphological characterization is usually performed to select better genotypes. This type of characterization identifies elite genotypes based on qualitative as well as quantitative traits. In present study 45 diverse rice germplasm were screened for important qualitative traits. The experiment was designed as augmented and important qualitative traits including leaf related traits, lodging, panicle shape, seed coat color and awn related traits were studied. Significant variations were observed for all the examined traits. Majority of genotypes showed resistance to lodging, and only few showed slight lodging. The brown seed coat color was found dominant among genotypes. All the studied traits included in the study were found useful for the identification of improved genotypes and these traits have direct relation with yield or yield related traits. However, to elucidate the particular responsible genes for these traits, further molecular based studies are recommended. Keywords: Genetic variability; Lodging; Morphological traits; Rice; Qualitative traits http://dx.doi.org/10.19045/bspab.2019.80056

Background: Head louses, commonly known as Pediculosis, is an infestation of the skin caused by a parasite known as Pediculus humanus capitis. Head louses are more common among crowded families, having poor hygiene and poor living condition. It can be easily transmitting from infected to healthy person. Methodology: This study was conducted in district Mardan of Pakistan. In this study, 202 head louse patients from 30 schools (15 males and 15 female’s elementary schools) were examined. A questionnaire was designed for data collection. Results: The occurrence of head louse was excessive among students having indigent living situation (78.7%), as compare to those students having good living condition (21.3%). Head louse rate was high (82.7%) among students with more than five family members living together. This study confirms that head louse rate was abundant in students having poor hygiene (72.8%). Head louses were more prevalent among students whose parents are illiterate (39.6%). This study shows that most functional treatment method was medication (72.3%). Conclusion: Results showed that head louses were common among students who need proper responsiveness. Its prevalence can be lowered by improving hygiene, living condition, and by educating people.

The present study is aimed at exploring the relationship between depression and self-assertiveness. Sample of the study consisted of 100 people (men = 50, women = 50), who were taken from different offices, houses, and hospitals. Their age ranged between 18 to 50 years, and education level was at least middle standard and above. Their marital status was of both types i.e. married and unmarried. They belonged to lower and middle socio-economic status. For the measurement of depression and self-assertiveness Urdu translation of Beck Depression Inventory (1996) and scale of self-assertiveness were used. Results indicated highly significant relationship between depression and self-assertiveness. The findings of the results also show that men are more assertive than women. They further show that low education makes a person non-assertive and depressed. Findings further reveal that men and women both can equally be the victim of depression in their life. Findings also suggest that married people are more assertive in comparison with unmarried people. Keywords : Depression, Assertiveness, Relationship, Gender Internet Journal of Medical Update Vol. 1 (2) 2006: pp. 9-16