Author: "Inês Santos" / Topic: business - Searchworks@Jio Institute Digital Library Search Results

57 results on '"Inês Santos"'

1. Evidence-Based Digital Tools for Weight Loss Maintenance

Author: Marja Harjumaa, Ruari O'Driscoll, Cristiana Duarte, R. James Stubbs, Lauren Ramsey, Euan Woodward, António L. Palmeira, Sarah E. Scott, Marie Louise K. Mikkelsen, Elina Mattila, Paul M. Sacher, Beth Pearson, Falko F. Sniehotta, Carol Stalker, Jake Turicchi, Elizabeth H. Evans, Inês Santos, Sofus C. Larsen, Marta M. Marques, Berit L. Heitmann, Pedro J. Teixeira, Marcela Matos, Miikka Ermes, Kirby Sainsbury, Graham W. Horgan, Jorge Encantado, and Repositório da Universidade de Lisboa
Subjects: Adult, RC620-627, Health (social science), Evidence-based practice, Cost-Benefit Analysis, BEHAVIOR-CHANGE, Applied psychology, Psychological intervention, BF, Behavioural sciences, Context (language use), Information and communication technologies, MASS, Weight loss maintenance, SDG 3 - Good Health and Well-being, Behavior Therapy, Physiology (medical), ECONOMIC BURDEN, Weight Loss, LOSS PROGRAMS, Humans, Medicine, TX341-641, Obesity, Position Statement, Nutritional diseases. Deficiency diseases, Goal setting, Consumer behaviour, Motivation, Nutrition. Foods and food supply, business.industry, Emotion regulation, ADULTS, Digital architecture, Digital health, OBESITY, Self-regulation, HEALTH, Energy Metabolism, business
Abstract: © 2021 The Author(s) Published by S. Karger AG, Basel. This is an Open Access article licensed under the Creative Commons Attribution-NonCommercial-4.0 International License (CC BY-NC) (http://www.karger.com/Services/OpenAccessLicense), applicable to the online version of the article only. Usage and distribution for commercial purposes requires written permission., Background: Effective interventions and commercial programmes for weight loss (WL) are widely available, but most people regain weight. Few effective WL maintenance (WLM) solutions exist. The most promising evidence-based behaviour change techniques for WLM are self-monitoring, goal setting, action planning and control, building self-efficacy, and techniques that promote autonomous motivation (e.g., provide choice). Stress management and emotion regulation techniques show potential for prevention of relapse and weight regain. Digital technologies (including networked-wireless tracking technologies, online tools and smartphone apps, multimedia resources, and internet-based support) offer attractive tools for teaching and supporting long-term behaviour change techniques. However, many digital offerings for weight management tend not to include evidence-based content and the evidence base is still limited. The Project: First, the project examined why, when, and how many European citizens make WL and WLM attempts and how successful they are. Second, the project employed the most up-to-date behavioural science research to develop a digital toolkit for WLM based on 2 key conditions, i.e., self-management (self-regulation and motivation) of behaviour and self-management of emotional responses for WLM. Then, the NoHoW trial tested the efficacy of this digital toolkit in adults who achieved clinically significant (≥5%) WL in the previous 12 months (initial BMI ≥25). The primary outcome was change in weight (kg) at 12 months from baseline. Secondary outcomes included biological, psychological, and behavioural moderators and mediators of long-term energy balance (EB) behaviours, and user experience, acceptability, and cost-effectiveness. Impact: The project will directly feed results from studies on European consumer behaviour, design and evaluation of digital toolkits self-management of EB behaviours into development of new products and services for WLM and digital health. The project has developed a framework and digital architecture for interventions in the context of EB tracking and will generate results that will help inform the next generation of personalised interventions for effective self-management of weight and health., The NoHoW project has received funding from the European Union Horizon 2020 research and innovation programme under grant agreement No. 643309. The Parker Institute, Bispebjerg and Frederiksberg Hospital, is supported by a core grant from the Oak Foundation (grant agreement No. OCAY-18-774-OFIL).
Published: 2021

2. Factors influencing the implementation of screening and brief interventions for alcohol use in primary care practices: a systematic review using the COM-B system and Theoretical Domains Framework

Author: Maria Inês Santos, Cristina Ribeiro, Kathryn Angus, Niamh Fitzgerald, Leo Pas, Frederico Rosário, and Repositório da Universidade de Lisboa
Subjects: Adult, Alcohol Drinking, Psychological intervention, 030508 substance abuse, Health Informatics, Context (language use), PsycINFO, CINAHL, Alcohol use disorder, Health informatics, 03 medical and health sciences, 0302 clinical medicine, Nursing, Alcohol-induced disorders, Humans, Mass Screening, Medicine, 030212 general & internal medicine, Primary health care, Motivation, lcsh:R5-920, business.industry, Health Policy, Public Health, Environmental and Occupational Health, Health services research, General Medicine, medicine.disease, Review (publication type), Crisis Intervention, MEDICINE::Psychiatry::Addiction medicine [Research Subject Categories], Screening, Psychological theory, Counselling, Systematic Review, Brief intervention, 0305 other medical science, business, lcsh:Medicine (General)
Abstract: © The Author(s). 2021 Open Access. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data, Background: Alcohol is a leading risk factor contributing to the global burden of disease. Several national and international agencies recommend that screening and brief interventions (SBI) should be routinely delivered in primary care settings to reducing patients' alcohol consumption. However, evidence shows that such activities are seldom implemented in practice. A review of the barriers and facilitators mediating implementation, and how they fit with theoretical understandings of behaviour change, to inform the design of implementation interventions is lacking. This study aimed to conduct a theory-informed review of the factors influencing general practitioners' and primary care nurses' routine delivery of alcohol SBI in adults. Methods: A systematic literature search was carried out in four electronic databases (Medline, CINAHL, CENTRAL, PsycINFO) using comprehensive search strategies. Both qualitative and quantitative studies were included. Two authors independently abstracted and thematically grouped the data extracted. The barriers and facilitators identified were mapped to the domains of the Capability-Opportunity-Motivation-Behaviour system/Theoretical Domains Framework (TDF). Results: Eighty-four out of the 258 studies identified met the selection criteria. The majority of the studies reported data on the views of general practitioners (n = 60) and used a quantitative design (n = 49). A total of 660 data items pertaining to barriers and 253 data items pertaining to facilitators were extracted and thematically grouped into 46 themes. The themes mapped to at least one of the 14 domains of the TDF. The three TDF domains with the highest number of data units coded were 'Environmental Context and Resources' (n = 158, e.g. lack of time), 'Beliefs about Capabilities' (n = 134, e.g. beliefs about the ability to deliver screening and brief advice and in helping patients to cut down) and 'Skills' (n = 99, e.g. lack of training). Conclusions: This study identified a range of potential barriers and facilitators to the implementation of alcohol SBI delivery in primary care and adds to the scarce body of literature that identifies the barriers and facilitators from a theoretical perspective. Given that alcohol SBI is seldom implemented, this review provides researchers with a tool for designing novel theory-oriented interventions to support the implementation of such activity.
Published: 2021

3. Realitätsnahe Finite-Elemente-Simulation in der präklinischen Testung von Knie- und Hüftimplantaten

Author: Arnd Steinbrück, Volkmar Jansson, Matthias Woiczinski, Peter E. Müller, Inês Santos, Thomas M. Grupp, Christoph Thorwächter, and Allan Maas
Subjects: Gynecology, 030222 orthopedics, 03 medical and health sciences, medicine.medical_specialty, 0302 clinical medicine, business.industry, medicine, Orthopedics and Sports Medicine, 030229 sport sciences, business, Finite element simulation
Abstract: In der Entwicklung eines Implantates dient die Computersimulation mittels der Finiten-Elemente(FE)-Methode der fruhzeitigen Identifikation designbedingter Schwachstellen, wodurch sich Entwicklungsschleifen auf ein Minimum reduzieren lassen. Weiterfuhrend wird die FE-Simulation fur die Auswahl der zu testenden Komponentenkombinationen eingesetzt, um zustandigen Behorden einen Nachweis des Worst-Case-Konstruktes fur den anschliesenden jeweiligen experimentellen Dauerfestigkeitstest zu erbringen. Finiten-Elemente-Simulationen und experimentelle Forschungsstudien zeigen, dass die Implantatpositionierung einen Einfluss auf die mechanischen Belastungen haben kann und damit auch unter Umstanden die praklinische Evaluierung der Prothesen beeinflussen kann. Damit erbringt die FE-Simulation derzeit schon einen wesentlichen Beitrag zur praklinischen Testung. Allerdings sollten die Berechnungsmodelle fur die Berechnung standardisiert werden, damit eine Vergleichbarkeit gegeben ist. Zusatzlich ist die Entwicklung neuer dynamischer und realitatsnaher Belastungsmodelle notig, um auch derzeit nicht darstellbare Schadensfalle vorab erkennen zu konnen. Mit speziellem Blick auf den Klinikalltag waren in Zukunft Modelle wunschenswert, die intraoperativ entstehende kinematische Veranderungen und resultierende Fehlbelastungen der Implantate darstellen konnen und die Adressierung durch eine veranderte Positionierung oder Verwendung eines anderen Prothesendesigns ermoglichen.
Published: 2020

4. Obstructive sleep apnea, shift work and cardiometabolic risk

Author: Isabel Rocha, Inês Santos, David Gozal, and Miguel Meira e Cruz
Subjects: Bioinformatics, Shift work, 03 medical and health sciences, 0302 clinical medicine, Humans, Medicine, Circadian rhythm, Cardiometabolic risk, Sleep Apnea, Obstructive, business.industry, Mechanism (biology), Shift Work Schedule, General Medicine, medicine.disease, Sleep in non-human animals, Circadian Rhythm, respiratory tract diseases, nervous system diseases, Obstructive sleep apnea, Autonomic nervous system, 030228 respiratory system, Cardiovascular Diseases, Autonomic modulation, Sleep, business, 030217 neurology & neurosurgery
Abstract: Obstructive Sleep Apnea (OSA) is one of the most common sleep disorders, and invokes numerous negative health-related outcomes and physiopathological processes. Understanding the mechanisms by which OSA potentiates cardiometabolic risk of patients remains a current challenge. Sleep disruption is highly prevalent among shift workers and shift work (SW) is an important modulator of circadian rhythms, with health consequences intimately related to cardiometabolic health. Since the circadian timing system (CTS) interacts with the normal functioning of the ANS, CTS impact on OSA patients should be closely assessed. This review raises the question of whether SW-induced circadian misalignment potentiates the cardiometabolic risk of OSA patients, providing a novel perspective on the role of autonomic modulation as a key downstream mechanism linking cardiometabolic risk with both OSA and CTS misalignment.
Published: 2020

5. Primary hepatic lymphoma in a patient with cirrhosis: a case report

Author: Joana Santos, Claudia R.L. Cardoso, Ana Paula Oliveira, Mariana Coelho, C Sequeira, Eduardo Dantas, and Inês Santos
Subjects: Liver Cirrhosis, Male, medicine.medical_specialty, Cirrhosis, Biopsy, lcsh:Medicine, Case Report, Physical examination, Asymptomatic, 03 medical and health sciences, 0302 clinical medicine, hemic and lymphatic diseases, medicine, Humans, Aged, medicine.diagnostic_test, business.industry, Lymphoma, Non-Hodgkin, lcsh:R, General Medicine, Diffuse large B-cell lymphoma, medicine.disease, Magnetic Resonance Imaging, Lymphoma, medicine.anatomical_structure, Primary hepatic lymphoma, 030220 oncology & carcinogenesis, Liver biopsy, Abdomen, 030211 gastroenterology & hepatology, Lymphoma, Large B-Cell, Diffuse, Radiology, medicine.symptom, business, Febrile neutropenia
Abstract: Background Primary hepatic lymphoma is a very uncommon disease. Due to its nonspecific clinical, laboratory, and imaging findings, it is often misdiagnosed. Liver biopsy is required to make a final diagnosis. Chemotherapy is the current gold standard of treatment. Case presentation An asymptomatic 65-year-old Caucasian man with Child-Pugh class A cirrhosis presented to our hospital with a nodular lesion seen on a routine surveillance abdominal ultrasound. His physical examination revealed hepatomegaly and no other significant findings. Magnetic resonance imaging of the abdomen showed a voluminous nodule on the left lobe with heterogeneous contrast enhancement. His liver biopsy was compatible with diffuse large B-cell lymphoma. Systemic staging showed no evidence of nodal or bone marrow involvement, confirming the diagnosis of primary hepatic lymphoma. He was treated with chemotherapy. However, he developed febrile neutropenia after one of the cycles and died. Conclusions In this article, we report a rare presentation of non-Hodgkin lymphoma and review the current literature on clinical features, diagnosis, and management.
Published: 2020

6. Exploring the relationship between the Mediterranean diet and weight loss maintenance: the MedWeight study

Author: Dimitrios Poulimeneas, Demosthenes B. Panagiotakos, James O. Hill, Mary Yannakoulia, Inês Santos, Costas A. Anastasiou, and Repositório da Universidade de Lisboa
Subjects: Adult, Male, Future studies, Adolescent, Mediterranean diet, Medicine (miscellaneous), Weight regain, Diet, Mediterranean, Diet Surveys, Body Mass Index, Body Weight Maintenance, Odds, Cohort Studies, Food group, Eating, Young Adult, Weight loss, Weight Loss, Odds Ratio, Humans, Medicine, Nutritional Physiological Phenomena, Obesity, Registries, Dietary patterns, Aged, Nutrition and Dietetics, Greece, business.industry, Weight control, Middle Aged, medicine.disease, Treatment Outcome, Quartile, Patient Compliance, Female, medicine.symptom, business, Demography, Linear trend
Abstract: © The Author(s), 2020. This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited., Weight loss maintenance is crucial for obesity management, yet optimal dietary patterns for this period are not established. We aimed to explore the relationship between adherence to the Mediterranean diet and weight loss maintenance. Sample includes 565 adults (62 % women) of the MedWeight study. Eligible volunteers were those reporting intentional weight loss of ≥10 %, starting from a BMI ≥ 25 kg/m2, over 12 months prior to enrolment. Based on current weight, participants were characterised as maintainers (≤90 % maximum weight) or regainers (>95 % maximum weight). Socio-demographics and weight history were recorded. Dietary intake was assessed by two non-consecutive 24-h recalls within 10 d and analysed in energy, macronutrient and food group intakes. Adherence to the Mediterranean diet was assessed with the Mediterranean Diet Score (MedDietScore) (range 0-55, greater scores showing higher adherence). Protein intake was higher in maintainers than in regainers (P < 0·001). When MedDietScore quartiles were considered, a linear trend for weight loss maintenance was revealed (P < 0·05). After adjustment for basic demographic characteristics, being in the third or fourth quartile of the MedDietScore (v. first) was associated with 2·30 (95 % CI 1·29, 4·09) and 1·88 (95 % CI 1·10, 3·22) increased odds of maintenance. Regarding individual MedDietScore components, only fruit intake is associated with increased odds for maintenance (1·03 (95 % CI 1·01, 1·06)). The leave-one-out approach revealed that at least six MedDietScore components were essential for the observed relationship. Higher adherence to the Mediterranean diet was associated with 2-fold increased likelihood of weight loss maintenance. Future studies should replicate these findings in non-Mediterranean populations as well., The MedWeight study was initially funded by the Coca-Cola Foundation (2012–2015, KA 221; Principal Investigator: Mary Yannakoulia). D. P. received financial support by the Greek State Scholarship Foundation (MIS 5000432).
Published: 2020

7. Users’ experiences with the NoHow web-based toolkit with weight and activity tracking in weight loss maintenance: long-term randomized controlled trial

Author: Marcela M Matos, Elina Mattila, António L. Palmeira, Sofus C. Larsen, Berit L. Heitmann, Alice Dunning, Graham W. Horgan, R. James Stubbs, Lauren Ramsay, Jorge Encantado, Liisa Lähteenmäki, Marja Harjumaa, Susanne Hansen, Marta M. Marques, Miikka Ermes, Cristiana Duarte, Marlene N. Silva, Lise Bundgaard, Jake Turicchi, Ruairi O'Driscoll, Inês Santos, and Repositório da Universidade de Lisboa
Subjects: Activity tracking, medicine.medical_specialty, Mixed methods, mixed methods, digital behavior change intervention, BF, Health Informatics, Digital behavior change intervention, law.invention, Physical medicine and rehabilitation, Randomized controlled trial, User experience design, law, Weight loss, user experience, technology acceptance, Surveys and Questionnaires, Weight Loss, medicine, Web application, Humans, Technology acceptance, Weight-loss maintenance, Exercise, Original Paper, mobile phone, Internet, User experience, business.industry, Focus groups, Term (time), focus groups, Preprint, medicine.symptom, Psychology, business, Mobile phone, weight loss maintenance
Abstract: ©Elina Mattila, Susanne Hansen, Lise Bundgaard, Lauren Ramsey, Alice Dunning, Marlene N Silva, Marja Harjumaa, Miikka Ermes, Marta M Marques, Marcela Matos, Sofus C Larsen, Jorge Encantado, Inês Santos, Graham Horgan, Ruairi O'Driscoll, Jake Turicchi, Cristiana Duarte, António L Palmeira, R James Stubbs, Berit Lilienthal Heitmann, Liisa Lähteenmäki. Originally published in the Journal of Medical Internet Research (https://www.jmir.org), 10.01.2022. This is an open-access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work, first published in the Journal of Medical Internet Research, is properly cited. The complete bibliographic information, a link to the original publication on https://www.jmir.org/, as well as this copyright and license information must be included., Background: Digital behavior change interventions (DBCIs) offer a promising channel for providing health promotion services. However, user experience largely determines whether they are used, which is a precondition for effectiveness. Objective: The primary aim of this study is to evaluate user experiences with the NoHoW Toolkit (TK)-a DBCI that targets weight loss maintenance-over a 12-month period by using a mixed methods approach and to identify the main strengths and weaknesses of the TK and the external factors affecting its adoption. The secondary aim is to objectively describe the measured use of the TK and its association with user experience. Methods: An 18-month, 2×2 factorial randomized controlled trial was conducted. The trial included 3 intervention arms receiving an 18-week active intervention and a control arm. The user experience of the TK was assessed quantitatively through electronic questionnaires after 1, 3, 6, and 12 months of use. The questionnaires also included open-ended items that were thematically analyzed. Focus group interviews were conducted after 6 months of use and thematically analyzed to gain deeper insight into the user experience. Log files of the TK were used to evaluate the number of visits to the TK, the total duration of time spent in the TK, and information on intervention completion. Results: The usability level of the TK was rated as satisfactory. User acceptance was rated as modest; this declined during the trial in all the arms, as did the objectively measured use of the TK. The most appreciated features were weekly emails, graphs, goal setting, and interactive exercises. The following 4 themes were identified in the qualitative data: engagement with features, decline in use, external factors affecting user experience, and suggestions for improvements. Conclusions: The long-term user experience of the TK highlighted the need to optimize the technical functioning, appearance, and content of the DBCI before and during the trial, similar to how a commercial app would be optimized. In a trial setting, the users should be made aware of how to use the intervention and what its requirements are, especially when there is more intensive intervention content., This project has received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement number 643309.
Published: 2022

8. Effectiveness of a lifestyle weight-loss intervention targeting inactive former elite athletes: the Champ4Life randomised controlled trial

Author: Catarina N Matias, Stephanie L. Dickinson, David B. Allison, Marlene N. Silva, Catarina L Nunes, Ruben Francisco, Miguel Cardoso, Analiza M. Silva, Eliana V. Carraça, Graham Finlayson, Filipe Jesus, Paulo A.F. Martins, Cláudia S. Minderico, Inês Santos, Luís B. Sardinha, and Repositório da Universidade de Lisboa
Subjects: Male, Quality of life, medicine.medical_specialty, Weight loss, Physical fitness, Physical Therapy, Sports Therapy and Rehabilitation, Overweight, Body composition, law.invention, Randomized controlled trial, law, Weight management, medicine, Humans, Orthopedics and Sports Medicine, Life Style, biology, business.industry, Athletes, General Medicine, medicine.disease, biology.organism_classification, Obesity, Physical therapy, Female, medicine.symptom, Sedentary Behavior, business
Abstract: © Author(s) (or their employer(s)) 2022. No commercial re-use. See rights and permissions. Published by BMJ., Objectives: Many athletes struggle in managing the end of their career, often gaining weight and adopting unhealthy lifestyles. Lifestyle programmes targeting former athletes who have gained substantial fat mass (FM) postsports career are lacking. We studied the effects of the Champ4Life programme on body composition and other health-related outcomes in former elite athletes with overweight or obesity. Methods: Ninety-four former athletes(42.4±7.3 y, 34.0% female) were recruited and randomly assigned to either an intervention group (IG; n=49) or a control group (CG; n=45). The IG attended 12 educational sessions addressing physical activity, weight management and nutrition. They also had a nutrition appointment aimed to prescribe a moderate caloric deficit(~300-500 kcal/day). Dual-energy X-ray absorptiometry was used to assess body composition. The Short-Form Health Survey-36 questionnaire was used to measure general health-related quality of life. Blood samples were collected to assess cardiometabolic health parameters. Results: At 12 months, the IG lost more weight (estimated difference (ED)=-5.3 kg; -6.9 to -3.8), total FM (ED=-4.1 kg; -5.4 to -2.8) and abdominal FM (ED=-0.49 kg; -0.64 to -0.33) than did the CG (p's, Financial support was provided by the Portuguese Institute of Sports and Youth and by the International Olympic Committee, under the Olympic Solidarity Promotion of the Olympic Values Unit (Sports Medicine and Protection of Clean Athletes Programme). The current work was also supported by national funding from the Portuguese Foundation for Science and Technology within the R&D units UIDB/00447/2020. CLN and RF were supported with a PhD scholarship from the Portuguese Foundation for Science and Technology (SFRH/BD/143725/2019 and 2020.05397.BD, respectively)
Published: 2022

9. Aortitis as a Harbinger of Esophageal Cancer

Author: Sandra Ganchinho Lucas, Inês Santos, Rita Rocha, Filipe Jorge Pencas Alfaiate, and Ireneia Lino
Subjects: medicine.medical_specialty, syndrome of fever of unknown origin, business.industry, General Engineering, Cardiology, Esophageal cancer, medicine.disease, paraneoplastic syndrome, Gastroenterology, large vessel paraneoplastic vasculitis, esophageal carcinoma, Rheumatology, arthritis, Internal medicine, medicine, Internal Medicine, business, aortitis, Aortitis
Abstract: Aortitis is a rare diagnosis that requires a high index of suspicion due to nonspecific symptoms and its multiplicity of etiologies. An 80-year-old man, independent in activities of daily living (ADLs), had three consecutive hospitalizations in three months for fever, general malaise, anorexia associated with arthritis of the hands and feet with the inability to walk. Inflammatory markers were increased without a focus of infection identified. Upper digestive endoscopy (UDE), colonoscopy, blood cultures, thoracoabdominal-pelvic CT and transthoracic (TT) echocardiogram were performed without changes, with discharge for consultation after demonstrating apyrexia. At the patient second hospitalization for fever and arthritis, a transesophageal echocardiogram was performed that showed the presence of multiple complex atherosclerotic plaques, with associated thrombi in all segments of the aorta with a suspicious mass of vegetation on the aorta. Thoracic-abdominopelvic CT demonstrated calcified atheromatosis of the entire aorta with para-aortic nodes; MRI showed aortic thickening; and autoimmunity study was negative. Aortitis was the working diagnosis of possible infectious etiology and anticoagulation and antibiotic therapy were started. Fever recurred and a third admission led to a working diagnosis of inflammatory, non-infectious aortitis. The patient responded well to empiric corticosteroids. The patient followed up in consultation, remained asymptomatic under a low dose of corticosteroids with negative temporal artery biopsy. In the sixth month, he repeated UDE due to dysphagia, which showed the presence of esophageal neoformation with the histological diagnosis of squamous cell carcinoma, maintaining on the CT as alterations in the aorta. This is an unusual case of aortitis associated with arthritis with improvement after corticosteroids, which interestingly occurred before the progression of esophageal cancer. In hindsight, we think this may have been a large vessel paraneoplastic vasculitis that preceded the detection of esophageal squamous cell carcinoma.
Published: 2021

10. Bronchogenic cyst of the neck in an elder patient: A case report

Author: Inês Santos, João Ferreira de Barros, Teresa Lopes, Isabel Amado, Leonor Barroso, and Margarida Mesquita
Subjects: Sistrunk procedure, medicine.medical_specialty, Thyroglossal duct, Bronchogenic cyst, Surgical planning, Asymptomatic, Article, 03 medical and health sciences, 0302 clinical medicine, Rare case, parasitic diseases, Case report, Duplication cyst, Medicine, Cyst, business.industry, medicine.disease, humanities, medicine.anatomical_structure, 030220 oncology & carcinogenesis, 030211 gastroenterology & hepatology, Surgery, Radiology, medicine.symptom, Presentation (obstetrics), business, Neck
Abstract: Highlights • Bronchogenic cysts are rare foregut duplications cysts. • Mostly diagnosed in children, they may be found in elder patients. • Neck bronchogenic cysts, albeit unusual, should be considered in the differential diagnosis of cystic masses of the neck. • Surgery is the treatment of choice for bronchogenic cysts., Introduction Bronchogenic cysts are rare malformations, mostly diagnosed in children. We report the rare case of a neck bronchogenic cyst diagnosed in an elderly patient. Presentation of case The patient complained of a long-standing submental mass. The diagnostic work-up resulted in a thyroglossal duct cyst diagnosis for which the patient underwent a Sistrunk procedure. However, the histological analysis of the lesion ultimately revealed a bronchogenic cyst. Discussion Neck bronchogenic cysts are rare and, in adults, normally asymptomatic. Imaging exams can suggest the diagnosis but they are most important for surgical planning. Surgery is the elected treatment for bronchogenic cysts and the histopathologic exam of the specimen provides definitive diagnosis. Conclusion This case demonstrates than even though they are a rare diagnosis, bronchogenic cysts should be considered in the diagnostic work-up of neck cysts, even in elderly patients.
Published: 2019

11. Environmental Life-Cycle Assessment of an Innovative Multifunctional Toilet

Author: Andreia do Socorros Silva da Costa, Carla Rodrigues, Maria Inês Santos, António Tadeu, Fausto Freire, João Almeida, Sandra Além, and Emanuel Rufo
Subjects: life-cycle assessment, toilet, Technology, Control and Optimization, Computer science, 020209 energy, bidet, Energy Engineering and Power Technology, 02 engineering and technology, 010501 environmental sciences, 01 natural sciences, law.invention, energy savings, Bidet, law, 0202 electrical engineering, electronic engineering, information engineering, Environmental impact assessment, Electrical and Electronic Engineering, Engineering (miscellaneous), Life-cycle assessment, 0105 earth and related environmental sciences, Consumption (economics), Toilet, Renewable Energy, Sustainability and the Environment, business.industry, user behavior, Environmental economics, eco-design, washlet, water savings, Electricity, business, Energy (miscellaneous)
Abstract: Innovative toilets can save resources, but have higher embodied impacts associated with materials and electronic components. This article presents an environmental life-cycle assessment (LCA) of an innovative multifunctional toilet (WashOne) for two alternative configurations (with or without washlet), comparing its performance with those of conventional systems (toilet and bidet). Additionally, two scenario analyses were conducted: (i) user behavior (alternative washlet use patterns) and (ii) user location (Portugal, Germany, the Netherlands, Sweden and Saudi Arabia). The results show that the WashOne with washlet has a better global environmental performance than the conventional system, even for low use. It also reveals that the use phase has the highest contribution to impacts due to electricity consumption. User location analysis further shows that Sweden has the lowest environmental impact, while Germany and the Netherlands have the highest potential for impact reduction when changing from a conventional system to the WashOne. Based on the overall results, some recommendations are provided to enhance the environmental performance of innovative toilet systems, namely the optimization of the washlet use patterns. This article highlights the importance of performing a LCA at an early stage of the development of innovative toilets by identifying the critical issues and hotspots to improve their design and performance.
Published: 2021
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12. Idiopathic Chronic Eosinophilic Pneumonia

Author: Natália Teixeira, Ana Mestre, Filipa Pedro, Maria João Pinto, and Maria Inês Santos
Subjects: Pathology, medicine.medical_specialty, Pulmonology, corticosteroid therapy, Infectious Disease, 030204 cardiovascular system & hematology, 03 medical and health sciences, 0302 clinical medicine, Eosinophilic, Internal Medicine, medicine, Eosinophilic pneumonia, pneumonia, Eosinophilia, Exertion, Respiratory system, business.industry, General Engineering, dyspnea, respiratory system, medicine.disease, respiratory tract diseases, idiopathic chronic eosinophilic pneumonia, Pneumonia, eosinophilic pneumonia, medicine.symptom, business, Infiltration (medical), 030217 neurology & neurosurgery, Rare disease
Abstract: Idiopathic chronic eosinophilic pneumonia (CEP) is a rare disease of unknown cause characterized by eosinophilic alveolar and interstitial infiltration. The authors describe the case of a 46-year-old black man, presenting with insidious onset and progressive course of dyspnea on minimum exertion, cough, fever, night sweats, and weight loss for one year and worsening in the last three months. The main findings were serum eosinophilia. Chest radiographs showed multifocal infiltrations of irregular distribution in both lungs and a restrictive functional impairment. The patient underwent open lung biopsy, and the anatomopathological examination revealed consolidation by exudate constituted predominantly by macrophages (25%) and eosinophils (51%), which filled small air spaces, including respiratory and membranous bronchioles. The anatomopathological diagnosis was eosinophilic pneumonia (eosinophils > 25% is widely accepted for diagnosing eosinophilic pneumonia). The patient had a good clinical response after starting corticosteroid therapy.
Published: 2021

13. The H2020 'NoHoW Project': A Position Statement on Behavioural Approaches to Longer-Term Weight Management

Author: Ruairi O'Driscoll, Berit L. Heitmann, António L. Palmeira, Falko F. Sniehotta, Jason C.G. Halford, Inês Santos, Sofus C. Larsen, Cristiana Duarte, Graham W. Horgan, Pedro J. Teixeira, Jake Turicchi, Dominika Kwasnicka, R. James Stubbs, Marta M. Marques, and Repositório da Universidade de Lisboa
Subjects: Weight loss, Health (social science), Energy (esotericism), Psychological intervention, Resistance (psychoanalysis), lcsh:TX341-641, Energy balance, behaviour change, Weight loss maintenance, Developmental psychology, Behavior Therapy, Physiology (medical), Intervention (counseling), Weight management, Medicine, Humans, Obesity, Position Statement, Exercise, lcsh:RC620-627, business.industry, Behaviour change, energy balance, Term (time), lcsh:Nutritional diseases. Deficiency diseases, Action (philosophy), medicine.symptom, weight loss, business, Energy Metabolism, lcsh:Nutrition. Foods and food supply, weight loss maintenance
Abstract: © 2021 The Author(s) Published by S. Karger AG, Basel. This article is licensed under the Creative Commons Attribution- NonCommercial-NoDerivatives 4.0 International License (CC BY- NC-ND) (http://www.karger.com/Services/OpenAccessLicense). Usage and distribution for commercial purposes as well as any distribution of modified material requires written permission., There is substantial evidence documenting the effects of behavioural interventions on weight loss (WL). However, behavioural approaches to initial WL are followed by some degree of longer-term weight regain, and large trials focusing on evidence-based approaches to weight loss maintenance (WLM) have generally only demonstrated small beneficial effects. The current state-of-the-art in behavioural interventions for WL and WLM raises questions of (i) how we define the relationship between WL and WLM, (ii) how energy balance (EB) systems respond to WL and influence behaviours that primarily drive weight regain, (iii) how intervention content, mode of delivery and intensity should be targeted to keep weight off, (iv) which mechanisms of action in complex interventions may prevent weight regain and (v) how to design studies and interventions to maximise effective longer-term weight management. In considering these issues a writing team within the NoHoW Consortium was convened to elaborate a position statement, and behaviour change and obesity experts were invited to discuss these positions and to refine them. At present the evidence suggests that developing the skills to self-manage EB behaviours leads to more effective WLM. However, the effects of behaviour change interventions for WL and WLM are still relatively modest and our understanding of the factors that disrupt and undermine self-management of eating and physical activity is limited. These factors include physiological resistance to weight loss, gradual compensatory changes in eating and physical activity and reactive processes related to stress, emotions, rewards and desires that meet psychological needs. Better matching of evidence-based intervention content to quantitatively tracked EB behaviours and the specific needs of individuals may improve outcomes. Improving objective longitudinal tracking of energy intake and energy expenditure over time would provide a quantitative framework in which to understand the dynamics of behaviour change, mechanisms of action of behaviour change interventions and user engagement with intervention components to potentially improve weight management intervention design and evaluation., The NoHoW project has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement No. 643309. The Parker Institute, Bispebjerg and Frederiksberg Hospital is supported by a core grant from the Oak Foundation (grant agreement No. OCAY-18-774-OFIL).
Published: 2021

14. Global variation in postoperative mortality and complications after cancer surgery: a multicentre, prospective cohort study in 82 countries

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Amarin, Rami Ayoub, Isam Bsisu, M S El Muhtaseb, Mohammad Jabaiti, Jamal Melhem, Yasmeen Z. Qwaider, Mohammad Hasan Salameh, Ahmad Suleihat, Haya H. Suradi, Mohammad Alammarin, Almoutuz Aljaafreh, Mohammad Bani hani, Zeina Bani hani, Farah Bani Hani, Toqa Fahmawee, Shadi Hamouri, Cyrine Katanani, Ra'fat Tawalbeh, Tamara Tawalbeh, Hassan Zawahrah, Mohamad K. Abou Chaar, Lana Abusalem, Mahmoud Al-Masri, Hani Al-Najjar, Lutfi Barghuthi, Zahra Ahmed, Adnan Maulana, Omar Ngotho, Charbel Kamau, Aruyaru Stanley Mwenda, Fridah Bosire, Elizabeth Mwachiro, Robert Parker, Ian Simel, Kimutai Sylvester, Abdulmunem Ahmed Mustafa Althini, Sofian Elbarouni, Aya Elseed Elbeshina, Ahmed Gwea, Ans Malek, Wedad Albashir Masoud Farag, Abdulwahab Abdalei, Abu Baker Abdel Malik, Areej Abo-khammash, Ma'aly Abuhlaiga, Nour Adnan, Marwa Albaggar, Asma Alfitory, Asma Aljanfi, Fakhruddin Almuzghi, Zohoor Altumei, Fatima Alzabti, Hana Ashoushan, Mohamed Assalhi, Joma Azzubia, Sondos Bnhameida, Malik Delhen, Houssein Elshafei, Hana Elteir, Fatima Esbaga, Abdel Aziz Gobbi, Fatma Hamouda, Hamdan Hilan, Rania Ismail, Fieruz Jebran, Muataz Kasbour, Galia Maderi, Saja Mohammad, Burooj Mohammed, Habib Murtadi, Hamassat Mustafa, Mohamed Rajab, Sarah Trenba, Mariam Wafaa, Eman Al Sagheir, Alabas Almigheerbi, Ahmed Alzahaf, Sumayyah Ghayth Bahroun, Najah Ben Dallah, Mahmoud Elshaibani, Haitem Eswaye, Maha Karar, Samah Omar, Eman Younes, Maha Younes, Dafer Zreeg, Saleh Abujamra, Firas Ashour, Mala Elgammudi, Wesal Omar F. Aljadidi, Enas Saddouh, Randa Sharif, Aya Alabuzidi, AbdulMawlay Alwerfally, Sarra Aribi, Fatma Bibas, Taha Elfaituri, Yasmine Elhajjaji, Ala Khaled, Wegdan Khalil, Tesneem Layas, Enas Soula, Ahmed Tarek, Muad fathi khalleefah Abu hallalah, Hazem Abdelkarem Ahmed, Tagwa Alsharef, Abdulsalam Ali Ben Saoud, Tasnim El Gharmoul, Ahmed Elhadi, Safa Elrais, Abdulhalim Shebani, Heba Zarti, Asaid Zeiton, Marijus Ambrazevicius, Nerijus Kaselis, Migle Stakyte, Oleg Aliosin, Agne Cizauskaite, Sarunas Dailidenas, Vitalijus Eismontas, Migle Kybransiene, Vitalija Nutautiene, Narimantas Samalavicius, Dainius Simcikas, Algirdas Slepavicius, Albinas Tamosiunas, Nerijus Ubartas, Paulius Zeromskas, Saulius Bradulskis, Edvinas Dainius, Juozas Juocas, Egle Kubiliute, Juozas Kutkevicius, Aurimas Opolskis, Audrius Parseliunas, Andrejus Subocius, Egle Virbickaite, Diana Zuikyte, Algirdas Bogusevicius, Kristina Buzaite, Daiva Cepuliene, Ieva Cesleviciene, Vaidotas Cesna, Jolanta Gribauskaite, Povilas Ignatavicius, Mantas Jokubauskas, Monika Liugailaite, Ernest Margelis, Ruta Mazelyte, Lina Pankratjevaite, Matas Pažusis, Agne Rackeviciute, Justina Saladyte, Monika Škimelyte, Vygintas Šlenfuktas, Monika Sudeikyte, Algimantas Tamelis, Tomas Vanagas, Žygimantas Žumbakys, Aivaras Atkociunas, Audrius Dulskas, Justas Kuliavas, Justas Birutis, Sigitas Paškevicius, Mindaugas Šatkauskas, Donatas Danys, Matas Jakubauskas, Lina Jakubauskiene, Marius Kryzauskas, Vytautas Lipnickas, Gabija Makunaite, Fanjandrainy Rasoaherinomenjanahary, Herizo Rasolofonarivo, Luc Hervé Samison, Bitiel Banda, Vanessa Msosa, Ahmad Imran Ahmad Izzuddin, Andre Das, Ying Yee Gan, Tan Shong Sheng, Jia yng Siaw, Mohd Fadliyazid Ab Rahim, Dyg Zahratul Hamrak Abang Jamari, Nurfariza Che Husin, Muhd Yusairi Kamarulzaman, Yi Ping Lim, Nil Amri Mohamed Kamil, Mohd Razeen Mohd Hassan, Saidah Mohd Sahid, Johari Mustafa, Elaine Hui Been Ng, Wan Khamizar Wan Khazim, Ng Chang Ern, P.g. Lingeshan, Syariz Ezuan Sulaiman, Sue Ean Ang, Muhammad Navid Bin Mohamad Sithik, Yih Jeng Cheong, Mahadevan Deva Tata, Law Jia Xian, Aravinthan Kadravello, I-Ern Koh, Li-Yen Ng, Yuki Julius Ng We Yong, Kandasami Palayan, Chi Xuan Sam, Phuah Siow Jin, Jeremy Tan Ern Hwei, Yita Tang, Alvin Zubin Ter, Michael Pak-Kai Wong, Andee Dzulkarnaen Zakaria, Zaidi Zakaria, Fitjerald Henry, Thyivya Kalaiselvan, Muhammad Fairuz Shah Abd Karim, Mohamed Rezal Abdul Aziz, Nora Abdul Aziz, Tak Loon Khong, Peng Choong Lau, Hiong Chin Lim, April Camilla Roslani, Jonathan Chen Ken Seak, Sui-Weng Wong, Lai Fen Wong, Leow Yeen Chin, Mercy Chinemerem Anyanwu, Zachary Busuttil, Thomas Calleja, Kurt Lee Chircop, Ruth Cutajar, Andrew Michael Dimech, Joseph Galea, Kiara Gascon Perai, Ruth Gatt, Lisa Kelman, Elizabeth Micallef, Favour Nwolu, Kim Sammut, Joanna Thompson, Sean Warwicker, Matthew Zammit, Fernando Cordera, Efraín Cruz González, Jorge Sánchez-García, Francisco José Barbosa Camacho, Francisco Javier Barrera López, Carlos Jose Zuloaga Fernandez del Valle, Eric Acosta, Iván Romarico González Espinoza, Perla Moreno, Ana Olivia Cortes-Flores, Clotilde Fuentes Orozco, Alejandro Gonzalez Ojeda, Samantha Corro Díaz González, Laura Martinez, Bonifacio Mosqueda Amador, Armando Novoa, Dennet Arturo Olazo Espejo, Alejandro Jimenez, Federico Lopez Rosales, Elva Gabriela Vanoye, Luis Alberto Garcia Gonzalez, Roberto Carlos Miranda-Ackerman, Manuel Solano-Genesta, Alethia Alvarez-Cano, Hector Hugo Romero-Garza, Heriberto Medina-Franco, Lorelí Mejía-Fernández, Noel Salgado-Nesme, Omar Vergara-Fernandez, Guadalupe Montserrat Gutiérrez-Mota, Francisco Xavier Hernandez Vera, Anabella Llantada Lopez, Gilberto Morgan Villela, Felipe de Jesus Ramirez Padilla, Walezka Tapia Marin, Mónica Martínez Maldonado, Ramses Sánchez Suárez, José Manuel Troche, Chaymae Benyaiche, Oumaima Outani, Souadka Amine, Amine Benkabbou, Anass Mohammed Majbar, Raouf Mohsine, Ali Rafik, Thida Oung, Moe Moe Tin, Philipp Plarre, Anna Alberga, Nina Sluiter, Jurriaan Tuynman, Robin Blok, Didem Cömert, Roel Hompes, Marianne Kalff, Merel Elisabeth Stellingwerf, Pieter Tanis, Mark van Berge Henegouwen, Elise Maria van Praag, Daan Wisselink, Michael Gerhards, Josephine Lopes Cardozo, Emma Westerduin, Joske de Jonge, Aaw van Geloven, Kaz van Schilt, Frank den Boer, Simone Stoots, Stijn Vlek, Jamie Adams, Ibrahim S. Al-Busaidi, Gabrielle Budd, Seung il Choi, Michael Jen Jie Chu, Anurag Ganugapati, Lucy McKinstry, Rebecca Pascoe, Simon Richards, Kenrick Rosser, Annie Stevenson, Rebecca White, Shebani Farik, Jin Kwun, Ahmed Murad, Sarah Cowan, Timothy Hall, Michael Hayton, Laminou Malam Sani, Souleymane Oumarou Garba, Ibrahim Amadou Magagi, Oumarou Habou, Halima Aliyu, Muhammad Daniyan, Tunde T. Sholadoye, Lawal Abdullahi, Lofty-John Anyanwu, Aminu Mohammad Mohammad, Abubakar Bala Muhammad, Abdurrahman Abba Sheshe, Ibrahim Suleiman, Alaba Adesina, Ajibola Awolowo, Clement Onuoha, Omotayo Salami, Ogechukwu Taiwo, Agboola Taiwo, Stephen Kache, Jerry Godfrey Makama, Danjuma Sale, Olajide Abiola, Akinlabi Ajao, Anthony Ajiboye, Amarachukwu Etonyeaku, Julius Olaogun, Ademola Adebanjo, Opeoluwa Adesanya, Michael Olatunji Afolayan, Olanrewaju Balogun, Ayomide Makanjuola, Samuel Nwokocha, Rufus Wale Ojewola, Thomas Olagboyega Olajide, Adewale Aderounmu, Abdul-Rashid Adesunkanmi, Augustine Agbakwuru, Adeleke Akeem Aderogba, Olusegun Isaac Alatise, Olukayode Arowolo, Oladejo Lawal, Tajudeen Mohammed, Chinedu Ndegbu, Olalekan Olasehinde, Funmilola Wuraola, Akinbolaji Akinkuolie, Arinzechukwu Mosanya, Omobolaji Ayandipo, Peter Elemile, Taiwo Akeem Lawal, Samuel Ali SANI, Stephen Garba, Rebecca Hauwa SANI, Samson Olori, Henry Onyebuashi, Ifeanyi Umoke, Adedire Adenuga, Ademola Adeyeye, Olufemi Habeeb, Bashir Lawal, Abdulrasheed Nasir, Eirik Kjus Aahlin, Didrik Kjønås, Elisabeth Myrseth, Jibran Abbasy, Abdul Alvi, Omair Saleem, Asma Afzal, Anam Nazir, Muhammad Farooq, Ayesha Liaqat, Syed Asghar Naqi, Ali Raza, Muzna Sarfraz, Muhammad Sarwar, Muntaha Banglani, Ambreen Munir, Rahmat Sehrish, Bushra Ayub, Raza Sayyed, Amna Altaf, Saima Ayub, Komal Saeed, Bilal Syed, Sana Amir Akbar, Abdul Wahid Anwer, Ruqayya Naheed Khan, Amina Iqbal Khan, Shahid Khattak, Sameen Mohtasham, Muhammad Asad Parvaiz, Aamir Ali Syed, Abdul Basit Ansari, Noman Shahzad, Tanwir Khaliq, Isbah Rashid, Shahzad Hussain Waqar, Hasan Abu Al-saleem, Amjad Abu Alqumboz, Mohammad Alqadi, Adham Amro, Rawan Assa, Eman Awesat, Rawan Ayyad, Mohammed Hammad, Ayat Haymony, Bassel Hijazi, Bara Hmeidat, Rowaa Lahaseh, Aseel Qawasmi, Alaa Rajabi, Mohammed Shehada, Sundus Shkokani, Yasmine Yaghi, Nadine Yaghi, Mohammad AlZohour, Mohammad Farid, Yousef Mahmoud Habes, Wesam Juba, Yanal Nubani, Abdelrahman Rabee, Mohammad Sa'deh, Saeed Abed, Iyad Al basos, Mohammad Alswerki, Dina Ashour, Israa Awad, Samar Diab, Alaa El Jamassi, Sahar El-Kahlout, Somaya Elhout, Ahmed N K Hajjaj, Doaa Hasanain, Baraa Nabil hajjaj, Mohammed Obaid, Eman Saikaly, Ahmed Salhi, Hiba Al-Tammam, Murad Almasri, Muath Baniowda, Doha Beshtawi, Ali Horoub, Rami Misk, Bayan Mohammad, Rami Qasrawi, Tasnim Sholi, Samar Abu-Nimeh, Abrar Abu-srour, Sadi A. Abukhalaf, Samer Adawi, Barah Alsalameh, Kholoud Ayesh, Muawiyah Elqadi, Ahmad Hammouri, Fatima Karim Mustafa, Natalie Marzouqa, Shatha Melhem, Dima Miqdad, Balqees Mohamad, Mhammed Rawhi, Ayman B. Abu Ahammala, Ahmed Abu Ataya, Israa Abu Jayyab, Samar Al-Shwaikh, Othman Alagha, Mohammed Alasttal, Haneen Awadallah, Mahmood Elblbessy, Jehad Fares, Akram Jarbou, Ibtisam Mahfouz, Moath A. Albahnasawi, Asmaa' Abo mahadi, Hasan Abuelhatal, Ayham Abuelqomboz, Abdelrahman Almoqayyad, Abdallah Alwali, Reem Balaawi, Mahmoud Hamouda, Mohammed Humeid, Abdullah Jedyan, Tasneem Mahmoud Abu hamam, Ghadeer Matar, Ali Salem, Tahani Samra, Nureddin Shaheen, Karam Shihada, Ayoob A.Nemer, Mahmoud Abu Al Amrain, Abdulwhhab Abu Alamrain, Najlaa Abu Jamie, Mohammed R. Abu-Rous, Nada Alfarra, Mohammed AlTaweel, Noor Alwhaidi, Ramadan Hamed, Bader Saqqa, Ahmad Shaheen, Dana Aljaber, Loay Aljaberi, Malak Alwaheidi, Assef Jawaada, Hani Khaldi, Rami Qahoush, Jalil Qari, Rana Saadeh, Ahlam Salim, Aseel Yacoub, Abbas Abbas, Rana Abu shua`ib, Baraa Abu Zainah, Mahmoud AbuSirrees, Basheer Babaa, Ola Barhoush, Asef Belal qadomi, Laith Daraghmeh, Reema Haji, Alaa Khatatbeh, Lana Khatib, Salsabeel Qarariah, Yara Quzmar, Khalil Safadi, Roqaya Salameh, Mohammad Hassan, Shifaa Herzallah, Loai Massad, Ahmed Nazzal, Ranin Nazzal, Dennis Escobar, Gustavo Miguel Machain V, Agustin Rodriguez Gonzalez, Jorge Emerson Chachaima Mar, Nathaly Olga Chinchihualpa Paredes, Vicente Cuba, Walter Lopez, Maria Milagros Niquen Jimenez, Nestor Alberto Sanchez Bartra, Olenka Sapallanay Ojeda, Diego Sequeiros, Andrea Toscano Pacheco, María Vergara, Sol Abarca, Rodrigo Alcorta, Giuliano Borda-Luque, Ivan Edward Eusebio Zegarra, Claudia Luján López, Mirella Marrufo, Cinthya Mogrovejo, Andrea Nomura, Yamile Rodríguez Angeles, Maitza Rosario Vidal Meza, Gabriela Zavala, José Neiser Castillo Arrascue, Jomara Caroline Hidrogo Cabrera, José Julio Mariano Larrea vera, Miguel Osorio, Edgar Alcides Ylatoma Díaz, Mark Anthony Fontanilla, Joseph Roy Fuentes, Anna Leah Salazar, Genieve Dominguez, Marc Paul Lopez, Shiela Macalindong, Mark Augustine Onglao, Arjel Ramirez, Marie Dione Sacdalan, Mayou Martin Tampo, Gemma Leonora Uy, Jeremiah Mangahas, Kenneth Yabut, Joannes Paul Cañete, Bernalynn Eris Cansana, Ernes John Castro, Maria Kaiserin Lipana, Manuel Francisco Roxas, Vlu Jean Zara, Maciej Chrol, Paula Franczak, Michal Orlowski, Piotr Budzynski, Andrzej Budzynski, Pawel Bury, Agata Czerwinska, Jadwiga Dworak, Jacek Dziedzic, Michal Kisielewski, Jan Kulawik, Anna Lasek, Piotr Malczak, Marcin Migaczewski, Michal Pedziwiatr, Magdalena Pisarska, Dorota Radkowiak, Mateusz Rubinkiewicz, Anna Rzepa, Tomasz Skoczylas, Maciej Stanek, Katarzyna Truszkiewicz, Mateusz Wierdak, Marek Winiarski, Piotr Zarzycki, Anna Zub-Pokrowiecka, Piotr Kowalewski, Rafal Roszkowski, Maciej Waledziak, Miguel Tomé, Sara Patrocinio, Ines Guerreiro, Filipe Almeida, Xavier de Sousa, Nuno Monteiro, Maria Teresa Costa Santos, Daniela de Oliveira, Marta Lopes Serra, Daniela Morgado, Christian Neves, Ana Carolina Oliveira, Alice Pimentel, Sofia Silva, Márcia Carvalho, Lúcia Carvalho, Joana Magalhães, Leonor Matos, Tânia Monteiro, Carlota Ramos, Vanessa Santos, José Barbosa, Jose Costa-Maia, Vítor Devezas, Ana Fareleira, Cristina Fernandes, Diana Gonçalves, Henrique Mora, Marina Morais, Fabiana Silva de Sousa, Sara Catarino Santos, Ana Logrado, André Tojal, Edgar Amorim, Miguel F. Cunha, Ana Fazenda, João Pedro Melo Neves, Inês Isabel Sampaio da Nóvoa Gomes Miguel, Diogo Veiga, José Azevedo, Hugo Cardoso Louro, Mariana Leite, Maria Bairos Menezes, Bárbara Gama, Diana Brito, Marta Cristina Cruz Martins, André Graça e Magalhães, Ana Catarina Longras, Rita Lourenço, Diana Matos, Luis Castro, Filipa Policarpo, Joana Romano, Cristina Monteiro, Diogo Pinto, Marina Duarte, Sónia Fortuna Martins, Mariline Oliveira, Diogo Galvão, Lisandra Martins, Anaisa Silva, Viorel Taranu, Bárbara Vieira, Jessica Neves, Simone Oliveira, Hugo Ribeiro, Margarida Cinza, Rosa Felix, Arnaldo Machado, Joana Oliveira, Joana Patrício, Rita Pedroso de Lima, Mário Pereira, Miguel Rocha Melo, Cristina Velez, Alberto Abreu da Silva, Mariana Claro, Daniel Costa Santos, Andreia Ferreira, Hugo Capote, Daniela Rosado, Filipa Taré, Oriana Nogueira, Miguel Ângelo, José Miguel Baiao, Andreia Guimarães, João Marques, Miguel Nico Albano, Marta Silva, Ana Valente da Costa, Teresa Vieira Caroço, Sara Almeida Braga, Ines Capunge, Marta Fragoso, João Guimarães, Bruno Pinto, João Ribeiro, Miguel Angel, Guilherme Fialho, Monica Guerrero, Filipa Campos Costa, Diogo Cardoso, Vasco Cardoso, Magda Alves, Inês Estalagem, Tiago Louro, Cláudia Marques, Rita Martelo, Miguel Morgado, Rita Canotilho, Ana Margarida Correia, Pedro Martins, Mariana Peyroteo, João Gomes, Rita Monteiro, Manuela Romano, Daniela Macedo Alves, Rita Peixoto, Catarina Quintela, Maria João Jervis, Débora Melo, André Pacheco, Valter Paixão, Vera Pedro, Joana Pimenta, João Pimenta de Castro, Ana Rocha, Mircea Beuran, Cezar Ciubotaru, Bogdan Diaconescu, Sorin Hostiuc, Ionut Negoi, Bogdan Stoica, NA NA, Evgeny Anokhin, Georgy Kuznetsov, Giorgi Oganezov, Fedor Paramzin, Ekaterina Romanova, Valeryan Rutkovskii, Vasilii Rutkovskii, Mikhail Shushval, Mikhail Zabiyaka, Khasan Dzhumabaev, Valerii Ivanov, Zaman Mamedli, Sergey Achkasov, Artem Balkarov, Elnur Nabiev, Marat Nagudov, Evgeny Rybakov, Karina Saifutdinova, Oleg Sushkov, Lule Joseph, Isaac Ndayishimiye, Ntirenganya Faustin, Alphonse Zeta Mutabazi, Jean Paul Mvukiyehe, Vizir J.P Nsengimana, Carine Uwakunda, Mohammad Monir Abbas, Nouf Akeel, Murad Aljiffry, Kholoud Awaji, Ali Farsi, Ghader Jamjoum, Ahmad Khoja, Ashraf Maghrabi, Nadim Malibary, Mohammed Nassif, Abdulaziz Saleem, Abdullah Sultan, Wail Tashkandi, Hanaa Tashkandi, Nora Trabulsi, Mouhamadou Bachir Ba, Adja Coumba Diallo, Abdourahmane Ndong, Vladica Cuk, Uroš Jankovic, Sharon Zhiling Koh, Frederick Koh, Kuok Chung Lee, Kai Yin Lee, Sean Lee, Wei Qi Leong, Su Ann Lui, Prajwala Prakash, Jan Grosek, Gregor Norcic, Ales Tomazic, Nicolas Fitchat, Robert Jaich, Devorah Wineberg, Modise Zacharia Koto, Daniella Baiocchi, Damian Clarke, Christina Johanna Steenkamp, Sharon Bannister, Adam Boutall, Galya Chinnery, Anna Coccia, Angela Dell, Parveen Karjiker, Christo Kloppers, Nicholas Loxton, Tumi Mabogoane, Francois Malherbe, Eugenio Panieri, Shreya Rayamajhi, Tirsa van Wyngaard, Claire Warden, T E Madiba, Nivashen Pillay, Savannah Brooks, Charlise Kruger, Lisa Hannah Van Der Merwe, Ferhana Gool, Maahir Kariem, Heather Bougard, Nazmie Kariem, Fazlin Noor, Reantha Pillay, Leandi Steynfaardt, Lucía González González, José Miguel Marín Santos, Paula Martín-Borregón, Javier Martínez Caballero, Cristina Nevado García, Pastora Rodriguez Fraga, Gonzalo De Castro Parga, Maria Pilar Fernández Veiga, Lucía Garrido López, Hugo Infante Pino, Irene Lages Cal, Marta López Otero, Manuel Nogueira Sixto, Marta Paniagua García Señorans, Laura Rodríguez Fernández, Alejandro Ruano Poblador, Erika Rufo Crespo, Raquel Sanchez-Santos, Vincenzo Vigorita, Ester Alonso Batanero, Dorisme Asnel, Isabel Cifrian Canales, Elisa Contreras Saiz, Irene De Santiago Alvarez, Tamara Díaz Vico, Sebastian Fernandez Arias, Daniel Fernández Martínez, Carmen García Bernardo, Luis Joaquín García Flórez, Carmen Garcia Gutierrez, Manuel García Munar, Carlos Alberto Márquez Zorrilla Molina, Marta Merayo, José Luis Michi Campos, Maria Moreno Gijon, Jorge L. Otero-Diez, Jose Luis Rodicio Miravalles, Lorena Solar-Garcia, Aida Suárez Sánchez, Nuria Truan, Cristina Alejandre Villalobos, Yurena Caballero Díaz, Marta Jimenez, Dacil Montesdeoca, Antonio Navarro-Sánchez, Victor Vega, Juan Beltrán de Heredia, Zahira Gómez, Carlos Jezieniecki, Ana Patricia Legido Morán, Mario Montes-Manrique, Mario Rodriguez-Lopez, María Ruiz Soriano, Jeancarlos Trujillo Díaz, Andrea Vazquez Fernandez, Nuria Argudo, Miguel Pera, Laia Torrent Jansà, Melody García Domínguez, Ignacio Goded, Marta Roldón Golet, Issa Talal El-Abur, Alejandra Utrilla Fornals, Vanesa Zambrana Campos, Maria Del Mar Aguilar Martinez, Marina Bosch, Luis García-Catalá, Luis Sánchez-Guillén, Eva Artigau, Nuria Gomez Romeu, David Julià Bergkvist, Beatriz Espina Perez, Olga Morató, Carles Olona, Beatriz Diéguez, Alexander Forero-Torres, Manuel Losada, Segundo Gomez-Abril, Paula Gonzálvez, Rosario Martinez, Sergio Navarro Martínez, Carmen Payá-Llorente, Álvaro Pérez Rubio, Sandra Santarrufina Martinez, Juan Carlos Sebastián Tomás, Ramon Trullenque Juan, Alberto Gegúndez Simón, Paloma Maté, Maria Isabel Prieto-Nieto, Ines Rubio-Perez, Aitor Urbieta, Marina Vicario Bravo, David Abelló, Matteo Frasson, Alvaro Garcia-Granero, Alfredo Abad Gurumeta, Ane Abad-Motos, Elena Lucena-de Pablo, Beatriz Nozal, Javier Ripollés-Melchor, Rut Salvachúa, Esther Ferrero, Luis Garcia-Sancho Tellez, Antonio L. Picardo, Jose Alberto Rojo López, Laura Patricia Zorrilla Matilla, Carmen Cagigas Fernandez, Sonia Castanedo Bezanilla, José Estevez Tesouro, Maria Jose Fernandez-Diaz, Juan García Cardo, Marcos Gomez Ruiz, Erik Gonzalez-Tolaretxipi, Jaime Jimeno Fraile, Cristobal Poch, Montserrat Rodriguez-Aguirre, Noemí Troche Pesqueira, Maria Soledad Trugeda-Carrera, Javier de la Torre, Ruth Blanco-Colino, Eloy Espin-Basany, Martin Espinosa-Bravo, Clara Morales Comas, Eduardo Reyes Afonso, Joaquín Rivero Déniz, Christian Siso Raber, Mireia Verdaguer Tremolosa, Pramodh Chandrasinghe, Sumudu Kumarage, Nimeshi Wijekoon Arachchilage, Ahmed Abdalla Ahmed Elkamel, Mohammed A. Adam, Nina Blomme, Anders Thorell, Fredrik Wogensen, Andreas Älgå, Dhirar Ansarei, Fuat Celebioglu, Göran Heinius, Linda Nigard, Emil Pieniowski, Sandra Ahlqvist, Ida Björklund, Andreas Frånberg, Martina Håkansson, Karin Adamo, Oskar Franklin, Malin Sund, Rebecca Wiberg, Yvette Andersson, Abbas Chabok, Maziar Nikberg, Alexander Kugelberg, Claudia Canonica, Dimitrios Christoforidis, Fabrizio Fasolini, Paolo Gaffuri, Mauro Giuliani, Francesco Meani, Sotirios Georgios Popeskou, Silvia Pozza, Wiebke Wandschneider, Lorenz Peterer, Lukas Werner Widmer, Bernd Zimmermann, Panagiotis Bakoleas, Iris Chanousi, Lydia Charalampidou, Lukasz Filip Grochola, Franziska Heid, Sotirios Ntaoulas, Michail Outos, Georgios Peros, Hanna Podolska-Skoczek, Katharina Beate Reinisch, Christian Zielasek, Nicolas Demartines, Jérôme Gilgien, Amaniel Kefleyesus, Pénélope St-Amour, Arnaud Toussaint, Maryam Alhimyar, Bayan Alsaid, Amr Alyafi, Ahmad Alkhaledi, Basel Kouz, Ahmad Omarain, Yusra Al-Sabbagh, Haya Alkhatib, Samer Sara, Ahmad Alhaj, Aghyad Danial, Lama Kadoura, Sarah Maa Albared, Yamen Monawar, Louei Nahas, Barook Abd, Ahmad Saad, Habib Wakkaf, Hatem Bouzaiene, Montassar Ghalleb, Elif Akaydin, Ata Cem Akbaba, Onur Atakul, Ege Baltaci, Sevval Besli, Gökçen Burgu, Ulukan Cenal, Cansu de Muijnck, Hasan Can Demirkaya, Alper Dogruoz, Zeynep Ipek Gezer, Yasemin Gündogdu, Merve Kara, Hasan Kürsad Korkmaz, Gökalp Kagan Kurtoglu, Volkan Ozben, Berk Baris Ozmen, Ahmet Murat Pektas, Eda Kübra Sel, Nilüfer Yenidünya, Fuat Baris Bengur, Berke Mustafa Oral, Tahir Koray Yozgatli, Seymur Abdullayev, Mehmet Emin Gunes, Nuri Alper Sahbaz, Tuba Banaz, Kübra Kargici, Omer Faruk Kuyumcu, Erkan Yanikoglu, Merve Yesilsancak, Duygu Yilmaz, Melik Kagan Aktas, Ahmet Rencuzogullari, Arda Isik, Sezai Leventoglu, Ali Yalçinkaya, Osman Yüksel, Mustafa U Kalayci, Yasin Kara, Inanc Samil Sarici, Alp Akin, Gökçe nur Alemdag, Ekin Arslan, Bahadir Emre Baki, Muhammed Selim Bodur, Adnan Calik, Bahar Candas Altinbas, Irem Cihanyurdu, Oguz Erkul, Burak Gül, Ali Guner, Beyza Köse, Anil Semiz, Sule Sevim, Serkan Tayar, Kadir Tomas, Ozan yavuz Tüfek, Serdar Türkyilmaz, Mehmet Ulusahin, Arif Usta, Reyyan Yildirim, Sertaç Ata Güler, Ozan Can Tatar, Ecenur Varol, Busenur Kirimtay, Muhammed Uysal, Alp Yildiz, Emin Kose, Ahmet Burak Ciftci, Elif Çolak, Huseyin Eraslan, Gultekin Ozan Kucuk, Kürsat Yemez, Herman Lule, Mumbere Bienfait, Emmanuel Bua, Noella Okalany, Maksym Basarab, Oleksii Bielosludtsev, Kateryna Kolhanova, Kateryna Perepelytsia, Kateryna Romanukha, Dmytro Savenkov, Stanislav Siryi, Maksym Tereshchenko, Nezamai Viacheslav, Anton Volovetskyi, Andrey Kebkalo, Yegor Tryliskyy, Volodimir Tyselskiy, Eilidh Bruce, Bing Lun Chow, Emma Iddles, Sarah McGuckin, Nicola Newall, George Ramsay, Parivrudh Sharma, Caitlin Stewart, Jeremy Wong, Abdul Badran, Michael Bath, Fanny Belais, Eman Butt, Kaustuv Joshi, Milan Kapur, Mike Shaw, Adam Townson, Christopher Yee Khang Williams, Timothy Gray, Robert Greig, Mansoor Husain, Elspeth Murray, Ahmed Mustafa, Ashar Asif, Arya Gokul, Max Shah, Mabel Temisanren Akitikori, Alexandros Charalabopoulos, Sophie Davidson, Sinead McNally, Shamil Rupani, Fatema Juma, Sarah Catherine Mills, Laura Muirhead, Kate Sellars, Una Walsh, Oliver Warren, Alice Chambers, Richard Hunt, Stephen Boyce, Hannah Cornwall, Isabel Tol, Eleftherios Orestis Argyriou, Nicola Eardley, Meical Povey, Joanna M S Aithie, Ahmer Irfan, Mari-Claire McGuigan, Robert Starr, Craig Russell Warren, Jess Archibald, Georgia Kirby, Ivan Kisyov, Chun Kheng Khoo, Rachel Lee, Dana Photiou, Rowan Davis, Uday Prasad, P Zichu Yang, Jonathan Bird, Edmund Leung, Virginia Summerour, Chelise Currow, Jianshen Kiam, Gerald Jack Soon Tan, Anitha Muthusami, Ibifunke Pegba-Otemolu, Tomas Urbonas, Joseph Nunoo-Mensah, Edgaras Smolskas, Alex Boddy, Gianpiero Gravante, David Hunter, David Andrew, Amanda Koh, Amari Thompson, Lawrence Adams, Hollie A Clements, Kasun De Silva, Ogbonnia Ekpete, Seraj Haque, Scott Henderson, Bilal Ibrahim, Thummini Jayasinghe, Jennifer Livie, Keir Mailley, Gopikrishnan Nair, Daniel Tan, Caitlin Baggaley, Aleksander Dawidziuk, Bartosz Szyszka, Charlotte Barter, Nirav Gandhi, Karen Hassell, Samantha Hitchin, Jennett Kelsall, Eva Nagy, Ashrafun Nessa, Lisa Whisker, Fady Yanni, Mahmoud Ali, Deeksha Arora, Sunanda Hediwattege, Navam Kumarasinghe, Munir Rathore, Athula Tennakoon, Syed Mustafa Ali Ahmad, Oreoluwa Bajomo, Fahema Nadira, Valerio Celentano, Ewen Griffiths, Rama Santhosh Karri, Jason Kei Chak Mak, Michelle Pipe, Muhammad Iqbal Bhatti, Mohamed Rabie, Connor Boyle, David Hamilton, Aishath Mihuna, James Chean Khun Ng, Gary Nicholson, Agata Oliwa, Robert Pearson, Anna Rose, Shun Qi Yong, Catherine Boereboom, Michael Hanna, Catherine Walter, Thomas Samuel Greensmith, Rachel Mitchell, Eimear Monaghan, James Crawford, Susan Moug, James Blackwell, Hannah Boyd-Carson, Philip Herrod, Omar Al-Allaf, Miriam Beattie, Cameron Bullock, Shivang Burman, Gemma Clark, Nicolas Flamey, Oliver Flannery, Alexander Harding, Ben Kodiatt, Samuel Lawday, Shivani Mahapatra, Navin Mukundu Nagesh, Michael Ng, Dupinderjit Rye, Andrel Yoong, Laura Clark, Chris Deans, Monisha Edirisooriya, Emma Victoria Carrington, Tsz Lun Ernest Wong, Baasil Yusuf, Carla Chamberlain, Kathryn Duke, Elizabeth Kmiotek, Azel Botes, Natalie Condie, Timothy Schrire, Reena Shah, Iolo Thomas-Jones, Charlotte Yates, Natasha Anthony, Edward Matthews, Kapil Sahnan, James Tankel, Sally Tucker, Jasmine Winter Beatty, Paul Ziprin, William Duggan, Anastasia Kantartzi, Shruthi Sridhar, Rachel Alys Khaw, Prakhar Srivastava, Charlotte Underwood, Homero Alves do Canto Brum, Sharat Chopra, Laura Davis, Rebecca Hughes, Joshua Tulley, Justin Alberts, Thomas Athisayaraj, Mojolaoluwa Olugbemi, Kasim Ahmad, Claudia Chan, Gavin Chapman, Hannah Fleming, Benjamin Fox, Julia Grewar, Kate Hulse, Duncan Rutherford, Mackay Sinead, Scott Smith, Doug Speake, Peter G Vaughan-Shaw, Natasha Christodoulides, Simrit 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A., Abu shua'ib R., Abu Zainah B., AbuSirrees M., Babaa B., Barhoush O., Belal qadomi A., Daraghmeh L., Haji R., Khatatbeh A., Khatib L., Qarariah S., Quzmar Y., Safadi K., Salameh R., Hassan M., Herzallah S., Massad L., Nazzal A., Nazzal R., Escobar D., Machain V G.M., Rodriguez Gonzalez A., Chachaima Mar J.E., Chinchihualpa Paredes N.O., Cuba V., Lopez W., Niquen Jimenez M.M., Sanchez Bartra N.A., Sapallanay Ojeda O., Sequeiros D., Toscano Pacheco A., Vergara M., Abarca S., Alcorta R., Borda-Luque G., Eusebio Zegarra I.E., Lujan Lopez C., Marrufo M., Mogrovejo C., Nomura A., Rodriguez Angeles Y., Vidal Meza M.R., Zavala G., Castillo Arrascue J.N., Hidrogo Cabrera J.C., Larrea vera J.J.M., Osorio M., Ylatoma Diaz E.A., Fontanilla M.A., Fuentes J.R., Salazar A.L., Dominguez G., Lopez M.P., Macalindong S., Onglao M.A., Ramirez A., Sacdalan M.D., Tampo M.M., Uy G.L., Mangahas J., Yabut K., Canete J.P., Cansana B.E., Castro E.J., Lipana M.K., Roxas M.F., Zara V.J., Chrol M., Franczak P., 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Adam M., Blomme N., Thorell A., Wogensen F., Alga A., Ansarei D., Celebioglu F., Heinius G., Nigard L., Pieniowski E., Ahlqvist S., Bjorklund I., Franberg A., Hakansson M., Adamo K., Franklin O., Sund M., Wiberg R., Andersson Y., Chabok A., Nikberg M., Kugelberg A., Canonica C., Christoforidis D., Fasolini F., Gaffuri P., Giuliani M., Meani F., Popeskou S.G., Pozza S., Wandschneider W., Peterer L., Widmer L.W., Zimmermann B., Bakoleas P., Chanousi I., Charalampidou L., Grochola L.F., Heid F., Ntaoulas S., Outos M., Peros G., Podolska-Skoczek H., Reinisch K.B., Zielasek C., Demartines N., Gilgien J., Kefleyesus A., St-Amour P., Toussaint A., Alhimyar M., Alsaid B., Alyafi A., Alkhaledi A., Kouz B., Omarain A., Al-Sabbagh Y., Alkhatib H., Sara S., Alhaj A., Danial A., Kadoura L., Maa Albared S., Monawar Y., Nahas L., Abd B., Saad A., Wakkaf H., Bouzaiene H., Ghalleb M., Akaydin E., Akbaba A.C., Atakul O., Baltaci E., Besli S., Burgu G., Cenal U., de Muijnck C., Demirkaya H.C., Dogruoz A., Gezer Z.I., Gundogdu Y., Kara M., Korkmaz H.K., Kurtoglu G.K., Ozben V., Ozmen B.B., Pektas A.M., Sel E.K., Yenidunya N., Bengur F.B., Oral B.M., Yozgatli T.K., Abdullayev S., Gunes M.E., Sahbaz N.A., Banaz T., Kargici K., Kuyumcu O.F., Yanikoglu E., Yesilsancak M., Yilmaz D., Aktas M.K., Rencuzogullari A., Isik A., Leventoglu S., Yalcinkaya A., Yuksel O., Kalayci M.U., Kara Y., Sarici I.S., Akin A., Alemdag G.N., Arslan E., Baki B.E., Bodur M.S., Calik A., Candas Altinbas B., Cihanyurdu I., Erkul O., Gul B., Guner A., Kose B., Semiz A., Sevim S., Tayar S., Tomas K., Tufek O.Y., Turkyilmaz S., Ulusahin M., Usta A., Yildirim R., Guler S.A., Tatar O.C., Varol E., Kirimtay B., Uysal M., Yildiz A., Kose E., Ciftci A.B., Colak E., Eraslan H., Kucuk G.O., Yemez K., Lule H., Bienfait M., Bua E., Okalany N., Basarab M., Bielosludtsev O., Kolhanova K., Perepelytsia K., Romanukha K., Savenkov D., Siryi S., Tereshchenko M., Viacheslav N., Volovetskyi A., Kebkalo A., Tryliskyy Y., Tyselskiy V., Bruce E., Chow B.L., Iddles E., McGuckin S., Newall N., Ramsay G., Sharma P., Stewart C., Wong J., Badran A., Bath M., Belais F., Butt E., Joshi K., Kapur M., Shaw M., Townson A., Williams C.Y.K., Gray T., Greig R., Husain M., Murray E., Mustafa A., Asif A., Gokul A., Shah M., Akitikori M.T., Charalabopoulos A., Davidson S., McNally S., Rupani S., Juma F., Mills S.C., Muirhead L., Sellars K., Walsh U., Warren O., Chambers A., Hunt R., Boyce S., Cornwall H., Tol I., Argyriou E.O., Eardley N., Povey M., Aithie J.M.S., Irfan A., McGuigan M.-C., Starr R., Warren C.R., Archibald J., Kirby G., Kisyov I., Khoo C.K., Lee R., Photiou D., Davis R., Prasad U., Yang P.Z., Bird J., Leung E., Summerour V., Currow C., Kiam J., Tan G.J.S., Muthusami A., Pegba-Otemolu I., Urbonas T., Nunoo-Mensah J., Smolskas E., Boddy A., Gravante G., Hunter D., Andrew D., Koh A., Thompson A., Adams L., Clements H.A., De Silva K., Ekpete O., Haque S., Henderson S., Ibrahim B., Jayasinghe T., Livie J., Mailley K., Nair G., Tan D., Baggaley C., Dawidziuk A., Szyszka B., Barter C., Gandhi N., Hassell K., Hitchin S., Kelsall J., Nagy E., Nessa A., Whisker L., Yanni F., Ali M., Arora D., Hediwattege S., Kumarasinghe N., Rathore M., Tennakoon A., Ali Ahmad S.M., Bajomo O., Nadira F., Celentano V., Griffiths E., Karri R.S., Mak J.K.C., Pipe M., Bhatti M.I., Rabie M., Boyle C., Hamilton D., Mihuna A., Ng J.C.K., Nicholson G., Oliwa A., Pearson R., Rose A., Yong S.Q., Boereboom C., Hanna M., Walter C., Greensmith T.S., Mitchell R., Monaghan E., Crawford J., Moug S., Blackwell J., Boyd-Carson H., Herrod P., Al-Allaf O., Beattie M., Bullock C., Burman S., Clark G., Flamey N., Flannery O., Harding A., Kodiatt B., Lawday S., Mahapatra S., Mukundu Nagesh N., Ng M., Rye D., Yoong A., Clark L., Deans C., Edirisooriya M., Carrington E.V., Wong T.L.E., Yusuf B., Chamberlain C., Duke K., Kmiotek E., Botes A., Condie N., Schrire T., Shah R., Thomas-Jones I., Yates C., Anthony N., Matthews E., Sahnan K., Tankel J., Tucker S., Winter Beatty J., Ziprin P., Duggan W., Kantartzi A., Sridhar S., Khaw R.A., Srivastava P., Underwood C., Alves do Canto Brum H., Chopra S., Davis L., Hughes R., Tulley J., Alberts J., Athisayaraj T., Olugbemi M., Ahmad K., Chan C., Chapman G., Fleming H., Fox B., Grewar J., Hulse K., Rutherford D., Sinead M., Speake D., Vaughan-Shaw P.G., Christodoulides N., Kudhail S., Welch M., Husaini S.M., Lambracos S., Anyanwu C., Suresh R., Thomas J.S., Gleeson E., Platoff R., Saif A., Enumah Z., Etchill E., Gabre-Kidan A., Bernstein M., Carrano F.M., Connors J., Lynn P., Melis M., Newman E., Foster D.S., Perrone K., Titan A., Ahmad S., Bafford A.C.M.D., Dal Molin M., Hanna N., Zafar S.N., Hemmila M., Napolitano L., Wong J.J., Chandler J., Wood L., Wren S., Ottesen T., You L., Yu K., Arcienega Yanez M.D.P., Ferreira Fernandes M., Gonzalez D., Cubas S., Gonzalez M.C., Zubiaurre V., Demolin R., Giroff N., Sciuto P., Campos M., Rodriguez Cantera G., Deepika G., Simuchimba E., Bulaya A., Chibuye C., Chirengendure B., Kabale M.-R., Kabongo K., Munthali J., Mweso O., Pikiti F., Otieno J., Lai L.T., Blackman B., Subramaniam S., Karim R., Kok N., Lee Y.D., Ali S., Sinha A., Corrigan R., Barnes N., Wong F., Dennis G., Jedamzik J., Phillips E., Piette W., Van hentenryck M., Koco H., Lawani S., Kassa M.W., Santos Bezerra T., Gribnev P., Dimitrov D., Krastev P., Oum S., Bonghaseh D.T., Al Farsi M., Alsharqawi N., Acevedo V., Castillo Barbosa A.C., Giron F., Leon Rodriguez J.P., Kucan D., Rosko D., Barsic N., Zupan D., Hegazi A., Truncikova V., Fryba V., Mohamed M., Nagi A., Rashad Temerik A., Elshawy M.E., Mahmoud M.I., Anwar M., Rageh T., Elmokadem A., Gaballa K., Teppo S., Pengerma P., Ballouhey Q., Bergeat D., Weyl A., Hain E., Gyedu A., Yenli E., Osei-Poku D., Rompou V.-A., Zoikas A., Gaitanidis A., Koukis G., Perivoliotis K., Tavlas P., Galanos-Demiris K., Zografos G., Karavokyros I., Xanthopoulou G., Iordanidou E., Ayau F., Garcia A., Damjan P., Wason D., B L A., Rangganata E., Kamath P., O'Connor D.B., Pinto M., Perrone F., Tropeano F.P., Troilo F., Bossi D., Scala D., Pulitano L., Carella M., Pietrabissa A., Gori A., Giraudo G., De Simone V., Russo A.A., Braccio B., Al-Taher R., Athamneh S., Parker A., Sawiee A., Kattia A., Tababa O., Shaeeb Z., Syminas V., Jurgaitis J., Damuleviciene G., Svagzdys S., Razafimanjato N.N.M., Chieng Loo L., Tiong I.C., Wan Muhmad W.F., Vijeyan H., Li Ying T., Grech G., Arrangoiz R., Jimenez Ley V.B., Arizpe D., Lagunes Lara E., Castro Lopez E.V., Eaazim J., Gordinou de Gouberville M., Bastiaenen V., Rottier S., Nahab F., Ji M.Y., Seyoji M., Nwachukwu C., Emeghara O., Muhammed S.E., Idowu A., Sowemimo O., Ogundoyin O., Akande O., Lott A., Nadeem M., Laghari A.A., Loya A., Mushtaq H., Abdullah M.T., Abuhilal B., Atawneh M., Hamdan H., Alhabil B., Srour A., Mousa I., Da Silva Medina L., Bartosiak K., Ferreira P., Francisco V., Lemos R., Frutuoso L., Fernandes S., Fonseca T., Pereira J., Rachadell J., Torre A., Madeira Martins F., Carvalho A.C., Rodrigues Ferreira J., Ribeiro da Silva B., Devesa H., Vieira A., Monica I., Amaro M., Sousa D., Reia M., Louro J., Martins A., Dominguez J., Santos I., Freitas Oliveira N.M., Pereira J.C., Silva-Vaz P., Freire L., Escrevente R., Negoita V.M., Shakhmatov D., Nezerwa Y., Radulovic R., Obery G., Viljoen F., Mendes T., Suarez A., Moncada E., Fernandez-Hevia M., Curtis Martinez C., Gil Garcia J.M., Gonzalez Zunzarren M., Idris T., Eklov K., Grahn O., Amin L., Blomqvist M., Ajani C., Kraus R., Seeger N., Willemin M., Rayya F., Ayash M., Msouti R., Kannas I., Abazid E., Esper A., Slim S., Kavcar A.S., Aytac E., Dural A.C., Ilker A., Eray I.C., Kurnaz E., Altiner S., Tepe M.D., Sahin C., Savli E., Innocent A., Babirye L., Diachenko A., Hordoskiy V., Curry H., Chau C.Y.C., Robertson H., Lennon H., Loi L., Kirkham E., McCann C., Watts D., Gurung B., Wilson M., Tribedi T., Garofalo E., Zahra B., MacDonald S., Daniels I., Ng N., Khosla S., Olivier J., Yue 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V., Ye, G., Zhang, G., Brooker, E., Feng, D., Lau, B., Ngai, C., Birks, S., Gyorki, D., Otero de Pablos, J., Abbosh, A., Gillespie, C., Mahmoud, A., Kwan, B., Lawson, J., Warwick, A., Bingham, J., Cockbain, A. J., Dudi-Venkata, N. N., Ellaby-Hall, J., Finlay, B., Humphries, E., Pisaniello, J., Pisaniello, M., Salih, S., Sammour, T., Abd Wahab, H. H., De Silva, A., Hayward, N., Iyer, K., Maddern, G., Prevost, G. A., Annapureddy, N., Settipalli, K. P., Yeo, J., Hempenstall, L., Pham, L., Purcell, S., Talavera, C., Vaska, A. I., Chaggar, G., Chrapko, P., Cocco, A., Coulter-Nile, S. M. C. J., Ctercteko, G., French, J., Gong, H., Gosselink, M., Jegathees, T., Jin, I., Kalachov, M., Kiefhaber, K., Lee, K., Luong, J., Phan, S., Pleass, H., Veale, K., Zeng, Z., Au, A., Debiasio, A., Deng, I., Myooran, J., Nair, A., Stewart, P., Stift, A., Unger, L. W., Wimmer, K., Ahmed, N., Hasan, S., Rahman, S., O'Shea, M., Padmore, G., Peters, A., Perduca, P., Pulcina, G., Tinton, N., Buxant, F., Dabin, E., Garofalo, G., Dossou, F., Gnangnon, F. H. R., Imorou Souaibou, Y., Motlaleselelo, P., Tlhomelang, O., Lima Buarque, I., Mendonca Ataide Gomes, G., Vieira Barros, A., Batashki, I., Damianov, N., Stoyanov, V., Dardanov, D., Maslyankov, S., Petkov, P., Todorov, G., Zhivkov, E., Akisheva, A., Castilla Moreno, M. A., Genov, G., Ilieva, I., Ivanov, T., Karamanliev, M., Khan, A., Mitkov, E., Yotsov, T., Atanasov, B., Belev, N., Slavchev, M., Nsengiyumva, C., Jones, E., Stock, S., Kyota, S., Brown, J., Mabanza, K. T., Nigo Samuel, L., Otuneme, C., Prosper, N., Umenze, F., Boutros, M., Caminsky, N., Dumitra, S., Garfinkle, R., Morency, D., Salama, E., Banks, A., Ferri, L., He, H., Katz, A., Liberman, A. 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A., Fadel, A., Habater, A., Hamdy, H., Hefni, A., Kamal, M., Mohamed Abobakr, N., Sayed, A., Shaker, N., Taha, E., Tharwat, H., Zakaria, O., Abdelmotaleb, I., Al-Dhufri, A., Al-Himyari, H. S., El sheikh, E., Eldmaty, A., Elkhalawy, A., M. Elkhashen, A., Magdy, K., Mostafa, S., Sadia, H. D., Saleh, M. M., Samir, D., Yahia Mohamed Ali, M., A. Nassar, M., Abdelhady, S., Abdelrazek, A., Abdelsalam, I., El-Sawy, A., Essam, E., Gadelkarim, M., Ghaly, K., Hassabalnaby, M., Masarani, R., Mohamed Shaaban, N., Sabry, A., Salem, M., Soliman, N. A., Zahran, D., Abou, El. soud M. R., Badr, E. T., Borham, H., Elmeslemany, N., Elsayed, M., Elsherif, F., Eslam, S., Gaber, G., Ibrahim, S., Kamh, Y., Mohamed, S. G., Morshedy, E., Omar, C., Salem Soliman, F., Abdelkawy, S., Abdelmohsen, N., Abdelshakour, M., Dahy, A., Gamal, N., Gamal, M., Hasan, A., Hetta, H., Mousa, N., Omar, M., Rabie, S., Saad, M., Saleh, B., Sayed Mohamed, M., Shawqi, M., Abdelhady Mousa, H., Alnoury, M., Elbealawy, M., Elshafey, A., Essam Ibrahim El Desouki Muhammad Ahmed, M., Ghonaim, M., Hgag, F., Ibrahim, M., Morsy, M., Reda Loaloa, M., Refaat, A., Samir, H., Shahien, F., Sobhy, M., Sroor, F., Abdellatif, E., Adel, M., Afifi, A. A., Afifi, E., Antaky, M., Dawoud, A., El Zoghby, N., El-remaily, A., Elzanfaly, A. A., Gadallah, A., Gamal, F. A., Hashem, O., Medhat Youssef, S., Muhammad Attyah, A., Munir, M., Shazly, O., Wilson, K., Adel, S., Ali, A., Eid, E., Elhelow, E., Elmahdy, M., Elshatby, B., Hossam el-din Zakaria, A., Hossny, A., Ibrahim, E., M. 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I., Veiga, D., Azevedo, J., Cardoso Louro, H., Leite, M., Bairos Menezes, M., Gama, B., Brito, D., Cruz Martins, M. C., Graca e Magalhaes, A., Longras, A. C., Lourenco, R., Matos, D., Castro, L., Policarpo, F., Romano, J., Monteiro, C., Pinto, D., Duarte, M., Fortuna Martins, S., Oliveira, M., Galvao, D., Martins, L., Silva, A., Taranu, V., Vieira, B., Neves, J., Oliveira, S., Ribeiro, H., Cinza, M., Felix, R., Machado, A., Oliveira, J., Patricio, J., Pedroso de Lima, R., Pereira, M., Rocha Melo, M., Velez, C., Abreu da Silva, A., Claro, M., Costa Santos, D., Ferreira, A., Capote, H., Rosado, D., Tare, F., Nogueira, O., Angelo, M., Baiao, J. M., Guimaraes, A., Marques, J., Nico Albano, M., Silva, M., Valente da Costa, A., Vieira Caroco, T., Almeida Braga, S., Capunge, I., Fragoso, M., Guimaraes, J., Pinto, B., Ribeiro, J., Angel, M., Fialho, G., Guerrero, M., Campos Costa, F., Cardoso, D., Cardoso, V., Alves, M., Estalagem, I., Louro, T., Marques, C., Martelo, R., Morgado, M., Canotilho, R., Correia, A. M., Martins, P., Peyroteo, M., Gomes, J., Monteiro, R., Romano, M., Alves, D. M., Peixoto, R., Quintela, C., Jervis, M. J., Melo, D., Pacheco, A., Paixao, V., Pedro, V., Pimenta, J., Pimenta de Castro, J., Rocha, A., Beuran, M., Ciubotaru, C., Diaconescu, B., Hostiuc, S., Negoi, I., Stoica, B., Na, N. A., Anokhin, E., Kuznetsov, G., Oganezov, G., Paramzin, F., Romanova, E., Rutkovskii, V., Shushval, M., Zabiyaka, M., Dzhumabaev, K., Ivanov, V., Mamedli, Z., Achkasov, S., Balkarov, A., Nabiev, E., Nagudov, M., Rybakov, E., Saifutdinova, K., Sushkov, O., Joseph, L., Ndayishimiye, I., Faustin, N., Mutabazi, A. 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Kadoura, Lama, Maa Albared, Sarah, Monawar, Yamen, Nahas, Louei, Abd, Barook, Saad, Ahmad, Wakkaf, Habib, Bouzaiene, Hatem, Ghalleb, Montassar, Akaydin, Elif, Akbaba, Ata Cem, Atakul, Onur, Baltaci, Ege, Besli, Sevval, Burgu, Gökçen, Cenal, Ulukan, de Muijnck, Cansu, Demirkaya, Hasan Can, Dogruoz, Alper, Gezer, Zeynep Ipek, Gündogdu, Yasemin, Kara, Merve, Korkmaz, Hasan Kürsad, Kurtoglu, Gökalp Kagan, Ozben, Volkan, Ozmen, Berk Baris, Pektas, Ahmet Murat, Sel, Eda Kübra, Yenidünya, Nilüfer, Bengur, Fuat Baris, Oral, Berke Mustafa, Yozgatli, Tahir Koray, Abdullayev, Seymur, Gunes, Mehmet Emin, Sahbaz, Nuri Alper, Banaz, Tuba, Kargici, Kübra, Kuyumcu, Omer Faruk, Yanikoglu, Erkan, Yesilsancak, Merve, Yilmaz, Duygu, Aktas, Melik Kagan, Rencuzogullari, Ahmet, Isik, Arda, Leventoglu, Sezai, Yalçinkaya, Ali, Yüksel, Osman, Kalayci, Mustafa U, Kara, Yasin, Sarici, Inanc Samil, Akin, Alp, Alemdag, Gökçe Nur, Arslan, Ekin, Baki, Bahadir Emre, Bodur, Muhammed Selim, Calik, Adnan, Candas Altinbas, Bahar, Cihanyurdu, Irem, Erkul, Oguz, Gül, Burak, Guner, Ali, Köse, Beyza, Semiz, Anil, Sevim, Sule, Tayar, Serkan, Tomas, Kadir, Tüfek, Ozan Yavuz, Türkyilmaz, Serdar, Ulusahin, Mehmet, Usta, Arif, Yildirim, Reyyan, Güler, Sertaç Ata, Tatar, Ozan Can, Varol, Ecenur, Kirimtay, Busenur, Uysal, Muhammed, Yildiz, Alp, Kose, Emin, Ciftci, Ahmet Burak, Çolak, Elif, Eraslan, Huseyin, Kucuk, Gultekin Ozan, Yemez, Kürsat, Lule, Herman, Bienfait, Mumbere, Bua, Emmanuel, Okalany, Noella, Basarab, Maksym, Bielosludtsev, Oleksii, Kolhanova, Kateryna, Perepelytsia, Kateryna, Romanukha, Kateryna, Savenkov, Dmytro, Siryi, Stanislav, Tereshchenko, Maksym, Viacheslav, Nezamai, Volovetskyi, Anton, Kebkalo, Andrey, Tryliskyy, Yegor, Tyselskiy, Volodimir, Bruce, Eilidh, Chow, Bing Lun, Iddles, Emma, McGuckin, Sarah, Newall, Nicola, Ramsay, George, Sharma, Parivrudh, Stewart, Caitlin, Wong, Jeremy, Badran, Abdul, Bath, Michael, Belais, Fanny, Butt, Eman, Joshi, Kaustuv, Kapur, Milan, Shaw, Mike, Townson, Adam, Williams, Christopher Yee Khang, Gray, Timothy, Greig, Robert, Husain, Mansoor, Murray, Elspeth, Mustafa, Ahmed, Asif, Ashar, Gokul, Arya, Shah, Max, Akitikori, Mabel Temisanren, Charalabopoulos, Alexandros, Davidson, Sophie, McNally, Sinead, Rupani, Shamil, Juma, Fatema, Mills, Sarah Catherine, Muirhead, Laura, Sellars, Kate, Walsh, Una, Warren, Oliver, Chambers, Alice, Hunt, Richard, Boyce, Stephen, Cornwall, Hannah, Tol, Isabel, Argyriou, Eleftherios Orestis, Eardley, Nicola, Povey, Meical, Aithie, Joanna M S, Irfan, Ahmer, McGuigan, Mari-Claire, Starr, Robert, Warren, Craig Russell, Archibald, Jess, Kirby, Georgia, Kisyov, Ivan, Khoo, Chun Kheng, Lee, Rachel, Photiou, Dana, Davis, Rowan, Prasad, Uday, Yang, P Zichu, Bird, Jonathan, Leung, Edmund, Summerour, Virginia, Currow, Chelise, Kiam, Jianshen, Tan, Gerald Jack Soon, Muthusami, Anitha, Pegba-Otemolu, Ibifunke, Urbonas, Tomas, Nunoo-Mensah, Joseph, Smolskas, Edgaras, Boddy, Alex, Gravante, Gianpiero, Hunter, David, Andrew, David, Koh, Amanda, Thompson, Amari, Adams, Lawrence, Clements, Hollie A, De Silva, Kasun, Ekpete, Ogbonnia, Haque, Seraj, Henderson, Scott, Ibrahim, Bilal, Jayasinghe, Thummini, Livie, Jennifer, Mailley, Keir, Nair, Gopikrishnan, Tan, Daniel, Baggaley, Caitlin, Dawidziuk, Aleksander, Szyszka, Bartosz, Barter, Charlotte, Gandhi, Nirav, Hassell, Karen, Hitchin, Samantha, Kelsall, Jennett, Nagy, Eva, Nessa, Ashrafun, Whisker, Lisa, Yanni, Fady, Ali, Mahmoud, Arora, Deeksha, Hediwattege, Sunanda, Kumarasinghe, Navam, Rathore, Munir, Tennakoon, Athula, Ali Ahmad, Syed Mustafa, Bajomo, Oreoluwa, Nadira, Fahema, Celentano, Valerio, Griffiths, Ewen, Karri, Rama Santhosh, Mak, Jason Kei Chak, Pipe, Michelle, Bhatti, Muhammad Iqbal, Rabie, Mohamed, Boyle, Connor, Hamilton, David, Mihuna, Aishath, Ng, James Chean Khun, Nicholson, Gary, Oliwa, Agata, Pearson, Robert, Rose, Anna, Yong, Shun Qi, Boereboom, Catherine, Hanna, Michael, Walter, Catherine, Greensmith, Thomas Samuel, Mitchell, Rachel, Monaghan, Eimear, Crawford, James, Moug, Susan, Blackwell, James, Boyd-Carson, Hannah, Herrod, Philip, Al-Allaf, Omar, Beattie, Miriam, Bullock, Cameron, Burman, Shivang, Clark, Gemma, Flamey, Nicolas, Flannery, Oliver, Harding, Alexander, Kodiatt, Ben, Lawday, Samuel, Mahapatra, Shivani, Mukundu Nagesh, Navin, Ng, Michael, Rye, Dupinderjit, Yoong, Andrel, Clark, Laura, Deans, Chris, Edirisooriya, Monisha, Carrington, Emma Victoria, Wong, Tsz Lun Ernest, Yusuf, Baasil, Chamberlain, Carla, Duke, Kathryn, Kmiotek, Elizabeth, Botes, Azel, Condie, Natalie, Schrire, Timothy, Shah, Reena, Thomas-Jones, Iolo, Yates, Charlotte, Anthony, Natasha, Matthews, Edward, Sahnan, Kapil, Tankel, James, Tucker, Sally, Winter Beatty, Jasmine, Ziprin, Paul, Duggan, William, Kantartzi, Anastasia, Sridhar, Shruthi, Khaw, Rachel Alys, Srivastava, Prakhar, Underwood, Charlotte, Alves do Canto Brum, Homero, Chopra, Sharat, Davis, Laura, Hughes, Rebecca, Tulley, Joshua, Alberts, Justin, Athisayaraj, Thomas, Olugbemi, Mojolaoluwa, Ahmad, Kasim, Chan, Claudia, Chapman, Gavin, Fleming, Hannah, Fox, Benjamin, Grewar, Julia, Hulse, Kate, Rutherford, Duncan, Sinead, Mackay, Smith, Scott, Speake, Doug, Vaughan-Shaw, Peter G, Christodoulides, Natasha, Kudhail, Simrit, Welch, Matthew, Husaini, Syed Muhibullah, Lambracos, Simon, Anyanwu, Chikamuche, Suresh, Rishi, Thomas, Jimmy Scott, Gleeson, Elizabeth, Platoff, Rebecca, Saif, Areeba, Enumah, Zachary, Etchill, Eric, Gabre-Kidan, Alodia, Bernstein, Mitchell, Carrano, Francesco Maria, Connors, Joseph, Lynn, Patricio, Melis, Marcovalerio, Newman, Elliot, Foster, Deshka S, Perrone, Kenneth, Titan, Ashley, Ahmad, Sarwat, Bafford, Andrea Chao M D, Dal Molin, Marco, Hanna, Nader, Zafar, Syed Nabeel, Hemmila, Mark, Napolitano, Lena, Wong, Jane J, Chandler, Julia, Wood, Lauren, Wren, Sherry, Ottesen, Taylor, You, Lucia, Yu, Kristin, Arciénega Yañez, María Del Pilar, Ferreira Fernandes, Martin, González, Daniel, Cubas, Santiago, González, María Catalina, Zubiaurre, Vanessa, Demolin, Rodrigo, Giroff, Nicolas, Sciuto, Pablo, Campos, Maite, Rodríguez Cantera, Gabriela, Deepika, Garg, Simuchimba, Elliot, Bulaya, Anadi, Chibuye, Chali, Chirengendure, Bright, Kabale, Mary-Rose, Kabongo, Kizito, Munthali, James, Mweso, Oliver, Pikiti, Francis, Otieno, James, Lai, Log Tung, Blackman, Brighid, Richards, Sophie, Subramaniam, Suren, Karim, Rafid, Kok, Nathan, Lee, Yanni Dion, Ali, Shabina, Sinha, Aanjaneya, Corrigan, Robert, Barnes, Nicole, Wong, Florence, Dennis, Grace, Jedamzik, Julia, Phillips, Emil, Piette, Wivine, Van Hentenryck, Marie, Koco, Houenoukpo, Lawani, Souliath, Kassa, Mamo Woldu, Santos Bezerra, Tainá, Gribnev, Petar, Dimitrov, Dobromir, Krastev, Panche, Oum, Sovannarith, Bonghaseh, Divine Tim, Al Farsi, Maryam, Alsharqawi, Nourah, Acevedo, Veronica, Castillo Barbosa, Andrea Carolina, Giron, Felipe, Leon Rodriguez, Jimmy Paul, Kucan, Darko, Rosko, Damir, Barsic, Neven, Župan, Domagoj, Hegazi, Amgad, Truncíková, Vendula, Fryba, Vladimir, Mohamed, Mostafa, Sultan, Ahmed, Nagi, Ahmed, Rashad Temerik, Abdallah, Elshawy, Mohamed Elemam, Mahmoud, Moustafa Ibrahim, Omar, Shrouk, Anwar, Mohamed, Rageh, Tarek, Elmokadem, Aya, Gaballa, Khaled, Teppo, Sandra, Turunen, Antti, Pengermä, Pasi, Ballouhey, Quentin, Bergeat, Damien, Weyl, Ariane, Hain, Elisabeth, Gyedu, Adam, Yenli, Edwin, Osei-Poku, Dorcas, Rompou, Vaia-Aliki, Zoikas, Athanasios, Gaitanidis, Apostolos, Koukis, Georgios, Perivoliotis, Konstantinos, Tavlas, Panagiotis, Galanos-Demiris, Konstantinos, Zografos, George, Karavokyros, Ioannis, Xanthopoulou, Georgia, Iordanidou, Eirini, Ayau, Fernanda, Garcia, Allan, Damján, Pekli, Wason, Deepender, B L, Ashika, Rangganata, Ervandy, Kamath, Prerna, O'Connor, Donal B, Pinto, Margherita, Perrone, Fabrizio, Tropeano, Francesca Paola, Troilo, Francesca, Bossi, Daniela, Scala, Dario, Pulitanò, Lucrezia, Carella, Marcella, Pietrabissa, Andrea, Gori, Alice, Giraudo, Giorgio, De Simone, Veronica, Russo, Alfio Alessandro, Braccio, Bartolomeo, Al-Taher, Raed, Athamneh, Sarah, Parker, Andrea, Sawiee, Adnan, Kattia, Amina, Salem, Malik, Tababa, Osama, Shaeeb, Zuhour, Syminas, Vilius, Jurgaitis, Jonas, Damuleviciene, Gyte, Svagzdys, Saulius, Poskus, Tomas, Razafimanjato, Narindra Njarasoa Mihaja, Chieng Loo, Ling, Tiong, Ing Ching, Wan Muhmad, Wan Farahiyah, Vijeyan, Harinthiran, Li Ying, Teoh, Grech, Gabriella, Arrangoiz, Rodrigo, Jimenez Ley, Vania Brickelia, Arizpe, Daniel, Lagunes Lara, Elizabeth, Castro López, Elizabeth Victoria, Eaazim, Jose, Gordinou de Gouberville, Marije, Bastiaenen, Vivian, Rottier, Simone, Nahab, Fouad, Ji, Maria Yeonhee, Seyoji, Mohammed, Nwachukwu, Callistus, Emeghara, Okechukwu, Muhammed, Sayyid Egbunu, Idowu, Ayodeji, Sowemimo, Olamiposi, Ogundoyin, Olakayode, Akande, Oluwatosin, Lott, Alexander, Nadeem, Maliha, Laghari, Ahsan Ali, Loya, Asif, Mushtaq, Hassan, Abdullah, Muhammad Tariq, Abuhilal, Baseel, Atawneh, Mohammad, Hamdan, Hamdan, Alhabil, Belal, Srour, Abedelrahman, Mousa, Ibrahim, Da Silva Medina, Luis, Bartosiak, Katarzyna, Ferreira, Pedro, Francisco, Vítor, Lemos, Ricardo, Frutuoso, Luísa, Fernandes, Sara, Fonseca, Telma, Pereira, Jorge, Rachadell, Juan, Torre, Ana, Madeira Martins, Filipe, Carvalho, Ana Cristina, Rodrigues Ferreira, Joana, Ribeiro da Silva, Bruno, Devesa, Helena, Vieira, Ana, Mónica, Inês, Amaro, Margarida, Sousa, Diogo, Reia, Marta, Louro, João, Martins, Ana, Dominguez, Joaquina, Santos, Inês, Freitas Oliveira, Nuno Miguel, Pereira, José Carlos, Silva-Vaz, Pedro, Freire, Ligia, Escrevente, Ricardo, Negoita, Valentina Madalina, Shakhmatov, Dmitry, Nezerwa, Yves, Radulovic, Radosav, Obery, Gareth, Viljoen, Francois, Mendes, Tome, Suarez, Antonio, Moncada, Enrique, Fernandez-Hevia, Maria, Curtis Martínez, Carolina, Gil Garcia, Julia Maria, González Zunzarren, Mariana, Idris, Tarig, Eklöv, Karolina, Grahn, Oskar, Amin, Leila, Blomqvist, Malin, Ajani, Costanza, Kraus, Rebecca, Seeger, Nico, Willemin, Melissa, Rayya, Fadi, Ayash, Mohammad, Msouti, Raneem, Kannas, Israa, Abazid, Eias, Esper, Asil, Slim, Skander, Kavcar, Akil Serdar, Aytac, Erman, Dural, Ahmet Cem, Ilker, Ayse, Eray, Ismail Cem, Kurnaz, Eray, Altiner, Saygin, Tepe, Mustafa Deniz, Sahin, Can, Savli, Evrim, Innocent, Aryon, Babirye, Lilian, Diachenko, Andrii, Hordoskiy, Vladislav, Curry, Heather, Chau, Charlene Yat Che, Robertson, Harry, Mahmoud, Arin, Lennon, Hannah, Loi, Lynette, Kirkham, Emily, McCann, Cameron, Watts, Daniel, Gurung, Binay, Wilson, Michael, Tribedi, Thomas, Garofalo, Eleonora, Zahra, Baryab, MacDonald, Scott, Daniels, Ian, Ng, Nathan, Khosla, Shivun, Olivier, James, Yue, Sum Yu Pansy, Suresh, Gayathri, Wellington, Jack, Lorejo, Emmanuel, Mossaad, Mafdi, Crutcher, Madison, Alimi, Marjan, Baiu, Ioana, Abdou, Hossam, Conway, Alison, Peck, Connor, Perdomo Perez, Mauro Andres, Zulu, Stanley, Nakazwe, Mildred, Burger, Sule, Davies, Justine, Donaldson, Rachel, Ede, Chikwendu, Garden, O James, Lesetedi, Chiapo, Mabedi, Charles, Magill, Laura, Makinde Alakaloko, Felix, Makupe, Alex, Monahan, Mark, Mulira, Soloman, Muller, Elmi, Musowoyo, Jospeh, Olory-Togbe, Jean Léon, Roberts, Tracey, Smith, Martin, Tayler, Viki, Windsor, John, Yepez, Raul, Sundar, Sudha, Runigamugabo, Emmy, Verjee, Azmina, Chen, José, Daya, Leonid, El Aroussi, Nouhaila, Farina, Valeria, Gnintedeme Olivier, Tchianze, Gonzales Nacarino, Mauricio, Hammani, Aamr, Honjo, Sarah, Jacobs, Rebecca, Kimura, Hitomi, Nkoronko, Mugisha, Oscullo Yepez, Jasson Javier, Pin Hung, Wei, Raj, Ankit, Romani Pozo, Alina, Rommaneh, Muna, Sassamela Fabiano, Samuel Chimbioputo, Shiroma Gago, Camila Milagros, Srinivas, Abhishekh, Sung, Chia-Yen, Tai, Aswan, Valle Aranda, Yener Cristyell, Venturini, Sara, and Wilguens Lartigue, Jean
Subjects: Pediatrics, Colorectal cancer, IMPACT, Disease, Colorectal Neoplasm, 030204 cardiovascular system & hematology, Cancer, surgery, postoperative mortality, 0302 clinical medicine, Postoperative Complications, Global health, 030212 general & internal medicine, Prospective Studies, Prospective cohort study, General Medicine, DISEASES, Income, cancer surgery, Colorectal Neoplasms, Breast Neoplasm, Cohort study, Human, Adult, Developed Countrie, medicine.medical_specialty, Global surgery, General surgery, International multicentre study, Cancer surgery, Breast Neoplasms, Department of Error, NO, Developing Countrie, 03 medical and health sciences, Breast cancer, Stomach Neoplasms, medicine, Humans, Developing Countries, Neoplasm Staging, business.industry, Developed Countries, Odds ratio, CARE, medicine.disease, 3126 Surgery, anesthesiology, intensive care, radiology, Prospective Studie, Postoperative Complication, business
Abstract: 80% of individuals with cancer will require a surgical procedure, yet little comparative data exist on early outcomes in low-income and middle-income countries (LMICs). We compared postoperative outcomes in breast, colorectal, and gastric cancer surgery in hospitals worldwide, focusing on the effect of disease stage and complications on postoperative mortality. 80% of individuals with cancer will require a surgical procedure, yet little comparative data exist on early outcomes in low-income and middle-income countries (LMICs). We compared postoperative outcomes in breast, colorectal, and gastric cancer surgery in hospitals worldwide, focusing on the effect of disease stage and complications on postoperative mortality. Background: 80% of individuals with cancer will require a surgical procedure, yet little comparative data exist on early outcomes in low-income and middle-income countries (LMICs). We compared postoperative outcomes in breast, colorectal, and gastric cancer surgery in hospitals worldwide, focusing on the effect of disease stage and complications on postoperative mortality. Methods: This was a multicentre, international prospective cohort study of consecutive adult patients undergoing surgery for primary breast, colorectal, or gastric cancer requiring a skin incision done under general or neuraxial anaesthesia. The primary outcome was death or major complication within 30 days of surgery. Multilevel logistic regression determined relationships within three-level nested models of patients within hospitals and countries. Hospital-level infrastructure effects were explored with three-way mediation analyses. This study was registered with ClinicalTrials.gov, NCT03471494. Findings: Between April 1, 2018, and Jan 31, 2019, we enrolled 15 958 patients from 428 hospitals in 82 countries (high income 9106 patients, 31 countries; upper-middle income 2721 patients, 23 countries; or lower-middle income 4131 patients, 28 countries). Patients in LMICs presented with more advanced disease compared with patients in high-income countries. 30-day mortality was higher for gastric cancer in low-income or lower-middle-income countries (adjusted odds ratio 3·72, 95% CI 1·70–8·16) and for colorectal cancer in low-income or lower-middle-income countries (4·59, 2·39–8·80) and upper-middle-income countries (2·06, 1·11–3·83). No difference in 30-day mortality was seen in breast cancer. The proportion of patients who died after a major complication was greatest in low-income or lower-middle-income countries (6·15, 3·26–11·59) and upper-middle-income countries (3·89, 2·08–7·29). Postoperative death after complications was partly explained by patient factors (60%) and partly by hospital or country (40%). The absence of consistently available postoperative care facilities was associated with seven to 10 more deaths per 100 major complications in LMICs. Cancer stage alone explained little of the early variation in mortality or postoperative complications. Interpretation: Higher levels of mortality after cancer surgery in LMICs was not fully explained by later presentation of disease. The capacity to rescue patients from surgical complications is a tangible opportunity for meaningful intervention. Early death after cancer surgery might be reduced by policies focusing on strengthening perioperative care systems to detect and intervene in common complications. Funding: National Institute for Health Research Global Health Research Unit.
Published: 2021

15. Effects of Ramadan and non-Ramadan intermittent fasting on body composition: a systematic review and meta-analysis

Author: Joana M. Correia, Inês Santos, Pedro Pezarat-Correia, Analiza M. Silva, Goncalo V. Mendonca, and Repositório da Universidade de Lisboa
Subjects: 0301 basic medicine, medicine.medical_specialty, Weight loss, Calorie, Energy restriction, Endocrinology, Diabetes and Metabolism, 030209 endocrinology & metabolism, lcsh:TX341-641, Body weight, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, Weight management, Intermittent fasting, Medicine, Exercise, Nutrition, 030109 nutrition & dietetics, Nutrition and Dietetics, business.industry, Diet, Meta-analysis, Observational study, Systematic Review, medicine.symptom, business, Body mass index, lcsh:Nutrition. Foods and food supply, Food Science
Abstract: Copyright © 2021 Correia, Santos, Pezarat-Correia, Silva and Mendonca. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms., Intermittent fasting (IF) has gained popularity for body-composition improvement purposes. The aim of this systematic review and meta-analysis was to summarize the effects of Ramadan vs. non-Ramadan IF on parameters of body composition. We conducted a comprehensive search of peer-reviewed articles in three electronic databases: PubMed, Scopus, and Web of Science (published until May 2020). Studies were selected if they included samples of adults (≥18 years), had an experimental or observational design, investigated any type of IF and included body composition outcomes. Meta-analytical procedures were conducted when feasible. Sixty-six articles met the eligibility criteria. We found that non-Ramadan IF is effective for decreasing body weight (-0.341 (95% CI [-0.584, -0.098], p = 0.006), body mass index (-0.699, 95% CI [-1.05, -0.347], p < 0.001), and absolute fat mass (-0.447, 95% CI [-0.673, -0.221], p < 0.001). When contrasting pre- post-intervention data on fat-free mass between treatments and controls, group-differences were non-significant (p > 0.05). Conversely, we observed a significant increase in fat-free mass when comparing pre- to post-intervention in a within design fashion (0.306, 95% CI [0.133, 0.48], p = 0.001). Finally, despite being accompanied by dehydration, Ramadan IF is effective in decreasing body weight (-0.353; 95% CI [-0.651, -0.054], p = 0.02) and relative fat mass (-0.533; 95% CI [-1.025, -0.04], p = 0.034). Ramadan IF seems to implicate some beneficial adaptations in weight management, although non-Ramadan IF appears to be more effective in improving overall body composition., This work was partly supported by the Fundação para a Ciência e Tecnologia, under Grant UIDB/00447/2020 to CIPER—Centro Interdisciplinar para o Estudo da Performance Humana (unit 447) and by Universidade de Lisboa (grant attributed to JC-n C00246e).
Published: 2021

16. Hair cortisol concentration, weight loss maintenance and body weight variability: a prospective study based on data from the european NoHoW trial

Author: Sofus C. Larsen, Jake Turicchi, Gitte L. Christensen, Charlotte S. Larsen, Niklas R. Jørgensen, Marie-Louise K. Mikkelsen, Graham Horgan, Ruairi O’Driscoll, Joanna Michalowska, Cristiana Duarte, Sarah E. Scott, Inês Santos, Jorge Encantado, Antonio L. Palmeira, R. James Stubbs, Berit L. Heitmann, and Repositório da Universidade de Lisboa
Subjects: Adult, Male, obesity, Weight loss, Hydrocortisone, Endocrinology, Diabetes and Metabolism, Physiology, Body weight, Stress, Body fat percentage, Weight loss maintenance, Diseases of the endocrine glands. Clinical endocrinology, Body Mass Index, stress, Endocrinology, Unit increase, Hair cortisol, hair cortisol, Medicine, Humans, Longitudinal Studies, Prospective Studies, Obesity, Prospective cohort study, Original Research, business.industry, Body Weight, Outcome measures, Middle Aged, medicine.disease, RC648-665, Prognosis, Cross-Sectional Studies, Female, sense organs, medicine.symptom, weight loss, business, Body mass index, weight loss maintenance, Biomarkers, Stress, Psychological, Follow-Up Studies, Hair
Abstract: Copyright © 2021 Larsen, Turicchi, Christensen, Larsen, Jørgensen, Mikkelsen, Horgan, O’Driscoll, Michalowska, Duarte, Scott, Santos, Encantado, Palmeira, Stubbs and Heitmann. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms., Several cross-sectional studies have shown hair cortisol concentration to be associated with adiposity, but the relationship between hair cortisol concentration and longitudinal changes in measures of adiposity are largely unknown. We included 786 adults from the NoHoW trial, who had achieved a successful weight loss of ≥5% and had a body mass index of ≥25 kg/m2 prior to losing weight. Hair cortisol concentration (pg/mg hair) was measured at baseline and after 12 months. Body weight and body fat percentage were measured at baseline, 6-month, 12-month and 18-month visits. Participants weighed themselves at home ≥2 weekly using a Wi-Fi scale for the 18-month study duration, from which body weight variability was estimated using linear and non-linear approaches. Regression models were conducted to examine log hair cortisol concentration and change in log hair cortisol concentration as predictors of changes in body weight, change in body fat percentage and body weight variability. After adjustment for lifestyle and demographic factors, no associations between baseline log hair cortisol concentration and outcome measures were observed. Similar results were seen when analysing the association between 12-month concurrent development in log hair cortisol concentration and outcomes. However, an initial 12-month increase in log hair cortisol concentration was associated with a higher subsequent body weight variability between month 12 and 18, based on deviations from a nonlinear trend (β: 0.02% per unit increase in log hair cortisol concentration [95% CI: 0.00, 0.04]; P=0.016). Our data suggest that an association between hair cortisol concentration and subsequent change in body weight or body fat percentage is absent or marginal, but that an increase in hair cortisol concentration during a 12-month weight loss maintenance effort may predict a slightly higher subsequent 6-months body weight variability., The NoHoW study has received funding from the European Union’s Horizon 2020 Research and Innovation Programme (grant agreement number 643309). The present ancillary study was supported by the Danish Health Foundation (Helsefonden) (grant agreement number 20-B-0405). The Parker Institute is supported by a core grant from the Oak Foundation (grant agreement number OCAY-18-774-OFIL).
Published: 2021

17. Abordagem da Granulomatose com Poliangeíte: A Propósito de um Caso Clínico

Author: Marta Cerol, Natália Teixeira, Filipa Pedro, Ana Rita Paulos, Cátia Cruz Correia, and Maria Inês Santos
Subjects: lcsh:R5-920, medicine.medical_specialty, Necrosis, business.industry, lcsh:R, Granulomatose com Poliangeíte, lcsh:Medicine, Disease, medicine.disease, Dermatology, Therapeutic approach, Male patient, medicine, medicine.symptom, Respiratory system, Presentation (obstetrics), lcsh:Medicine (General), business, Granulomatosis with polyangiitis, Systemic vasculitis
Abstract: A granulomatose com poliangeíte é uma vasculite sistémica rara e idiopática caracterizada pelo atingimento dos pequenos e médios vasos. A doença atinge, preferencialmente, a vias aéreas superior e inferior e os rins, levando à formação de granulomas e necrose destes órgãos. As manifestações clínicas e o envolvimento orgânico são muito variáveis. O diagnóstico e tratamento são fundamentais e o atraso no diagnóstico pode ser fatal. Os autores apresentam o caso de um doente de sexo masculino, com uma apresentação atípica da doença, onde se documentou envolvimento do trato respiratório e cerebral, mas com uma evolução favorável após diagnóstico e tratamento adequado. Neste trabalho pretendemos fazer uma revisão da doença, formas de apresentação, critérios diagnósticos, abordagem terapêutica e prognóstica.
Published: 2020

18. Organizing Pneumonia After Exposure to Sodium Hypochlorite: A Case Report

Author: Inês Santos, Sandra Ganchinho Lucas, Ireneia Lino, and Rui Seixas
Subjects: medicine.medical_specialty, Isolation (health care), Pulmonology, medicine.drug_class, organizing pneumonia, transbronchial lung biopsy, Antibiotics, corticosteroid therapy, 030204 cardiovascular system & hematology, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Internal medicine, medicine, Internal Medicine, interstitial lung disease, business.industry, Transbronchial lung biopsy, General Engineering, Interstitial lung disease, medicine.disease, chemistry, Sodium hypochlorite, Toxicity, Etiology, Emergency Medicine, sodium hypoclorite, Organizing pneumonia, corticosteroid-sparing agent, business, 030217 neurology & neurosurgery
Abstract: Organizing pneumonia (OP) is a rare inflammatory lung disease with a difficult diagnosis and sparse mentions in the literature. In most cases, the etiology is unknown but may be associated with infections, systemic disorders, exposure to industrial toxins and environmental pollutants, or even drug toxicity. This report describes a 77-year-old male who presented to the hospital with nonproductive cough, myalgias, fever, and progressive weight loss after prolonged exposure to sodium hypochlorite. The patient was treated with multiple courses of antibiotics with no pathogen isolation. Chest CT revealed condensation foci of all pulmonary lobes. His clinical history, laboratory results, and CT images led to the diagnosis of OP, which was confirmed with a transbronchial lung biopsy. The patient was treated with oral prednisolone with clinical improvement and discharge one week after the beginning of the corticosteroid treatment. OP diagnosis can be challenging and, if not considered, may lead to a delay in providing appropriate treatment to the patients, which can often lead to a prolonged hospital stay and poor outcomes.
Published: 2020

19. Consistent sleep onset and maintenance of body weight after weight loss: An analysis of data from the NoHoW trial

Author: Marie-Louise K Mikkelsen, Sarah E. Scott, Sofus C. Larsen, R. James Stubbs, Jake Turicchi, Cristiana Duarte, Ruairi O'Driscoll, Inês Santos, Joanna Michalowska, Graham W. Horgan, Jorge Encantado, Berit L. Heitmann, António L. Palmeira, and Repositório da Universidade de Lisboa
Subjects: Male, Time Factors, Physiology, Emotions, Social Sciences, Blood Pressure, 030204 cardiovascular system & hematology, Body fat percentage, Vascular Medicine, 0302 clinical medicine, Weight loss, Medicine and Health Sciences, Psychology, Public and Occupational Health, 030212 general & internal medicine, METABOLIC SYNDROME, Alcohol Consumption, General Medicine, ASSOCIATION, Middle Aged, Sleep in non-human animals, Physiological Parameters, OBESITY, Body Composition, Medicine, Female, medicine.symptom, Sleep onset, Research Article, Adult, medicine.medical_specialty, DURATION, 03 medical and health sciences, Internal medicine, Linear regression, Weight Loss, medicine, Humans, QUALITY, Obesity, METAANALYSIS, Nutrition, CONSEQUENCES, business.industry, Body Weight, Biology and Life Sciences, Physical Activity, medicine.disease, Diet, Blood pressure, Observational study, GAIN, business, Sleep, Physiological Processes
Abstract: Background Several studies have suggested that reduced sleep duration and quality are associated with an increased risk of obesity and related metabolic disorders, but the role of sleep in long-term weight loss maintenance (WLM) has not been thoroughly explored using prospective data. Methods and findings The present study is an ancillary study based on data collected on participants from the Navigating to a Healthy Weight (NoHoW) trial, for which the aim was to test the efficacy of an evidence-based digital toolkit, targeting self-regulation, motivation, and emotion regulation, on WLM among 1,627 British, Danish, and Portuguese adults. Before enrolment, participants had achieved a weight loss of ≥5% and had a BMI of ≥25 kg/m2 prior to losing weight. Participants were enrolled between March 2017 and March 2018 and followed during the subsequent 12-month period for change in weight (primary trial outcome), body composition, metabolic markers, diet, physical activity, sleep, and psychological mediators/moderators of WLM (secondary trial outcomes). For the present study, a total of 967 NoHoW participants were included, of which 69.6% were women, the mean age was 45.8 years (SD 11.5), the mean baseline BMI was 29.5 kg/m2 (SD 5.1), and the mean weight loss prior to baseline assessments was 11.4 kg (SD 6.4). Objectively measured sleep was collected using the Fitbit Charge 2 (FC2), from which sleep duration, sleep duration variability, sleep onset, and sleep onset variability were assessed across 14 days close to baseline examinations. The primary outcomes were 12-month changes in body weight (BW) and body fat percentage (BF%). The secondary outcomes were 12-month changes in obesity-related metabolic markers (blood pressure, low- and high-density lipoproteins [LDL and HDL], triglycerides [TGs], and glycated haemoglobin [HbA1c]). Analysis of covariance and multivariate linear regressions were conducted with sleep-related variables as explanatory and subsequent changes in BW, BF%, and metabolic markers as response variables. We found no evidence that sleep duration, sleep duration variability, or sleep onset were associated with 12-month weight regain or change in BF%. A higher between-day variability in sleep onset, assessed using the standard deviation across all nights recorded, was associated with weight regain (0.55 kg per hour [95% CI 0.10 to 0.99]; P = 0.016) and an increase in BF% (0.41% per hour [95% CI 0.04 to 0.78]; P = 0.031). Analyses of the secondary outcomes showed that a higher between-day variability in sleep duration was associated with an increase in HbA1c (0.02% per hour [95% CI 0.00 to 0.05]; P = 0.045). Participants with a sleep onset between 19:00 and 22:00 had the greatest reduction in diastolic blood pressure (DBP) (P = 0.02) but also the most pronounced increase in TGs (P = 0.03). The main limitation of this study is the observational design. Hence, the observed associations do not necessarily reflect causal effects. Conclusion Our results suggest that maintaining a consistent sleep onset is associated with improved WLM and body composition. Sleep onset and variability in sleep duration may be associated with subsequent change in different obesity-related metabolic markers, but due to multiple-testing, the secondary exploratory outcomes should be interpreted cautiously. Trial registration The trial was registered with the ISRCTN registry (ISRCTN88405328)., Sofus Larsen and colleagues reveal the importance of consistent sleep patterns to avoid weight gain after weight loss, Author summary Why was this study done? Weight loss maintenance (WLM) is the greatest challenge in successful treatment of obesity. While several studies have suggested that reduced sleep duration and quality are associated with an increased risk of obesity, the role of sleep in long-term WLM has not been thoroughly examined. What did the researchers do and find? This study included a total of 967 men and women who had achieved a clinically significant weight loss (≥5%) during the last 12 months and had a BMI of ≥25 kg/m2 prior to their weight loss. Sleep duration, sleep duration variability, sleep onset, and sleep onset variability were assessed across 14 days close to baseline examinations using the Fitbit Charge 2 (FC2) device, and changes in body weight (BW), composition, and obesity-related metabolic markers were followed up after 12 months. While no associations were found between sleep duration, sleep duration variability, or sleep onset and subsequent WLM, participants with a more variable sleep onset at baseline regained more weight and had a higher increase in body fat percentage (BF%) during the 12-month follow-up period. What do these findings mean? These results suggest that maintaining a consistent sleep onset may be associated with improved WLM and body composition. Due to the observational design, the study cannot confirm whether this relationship is causal or a reflection of different personality traits related to sleep onset variability and energy balance behaviours.
Published: 2020

20. Successful weight loss maintenance: A systematic review of weight control registries

Author: Mary Yannakoulia, Martina de Zwaan, Sirpa Soini, Pedro J. Teixeira, James O. Hill, Catarina Paixão, Eliana V. Carraça, Rui Jorge, Carlos Matias Dias, Inês Santos, and Repositório da Universidade de Lisboa
Subjects: Adult, Male, Web of science, Dietary Sugars, Endocrinology, Diabetes and Metabolism, Fatty foods, Behaviours, Scopus, 030209 endocrinology & metabolism, Weight loss maintenance, Body Weight Maintenance, 03 medical and health sciences, 0302 clinical medicine, Weight loss, Environmental health, Vegetables, Weight Loss, Weight management, medicine, Humans, Registries, 030212 general & internal medicine, Prospective cohort study, Exercise, Breakfast, 2. Zero hunger, Cognitive Behavioral Therapy, business.industry, Public Health, Environmental and Occupational Health, correlates, Weight control, Middle Aged, medicine.disease, Dietary Fats, Obesity, 3. Good health, Weight Loss Maintenance, behaviours, Correlates, Female, Diet, Healthy, Determinantes da Saúde e da Doença, medicine.symptom, business, weight loss maintenance
Abstract: © 2020 World Obesity Federation, Weight loss maintenance is a major challenge for obesity treatment. Weight control registries can be useful in identifying psychological and behavioural factors that could contribute to better long-term success. The objective of this study is to describe the existing weight control registries and their participants and identify correlates of weight loss maintenance. A comprehensive search of peer-reviewed articles published until November 2018 was conducted in PubMed, Web of Science, and Scopus. Studies that reported results from weight control registries were considered. Fifty-two articles, corresponding to five registries (the United States, Portugal, Germany, Finland, and Greece), were included. Registries differed in inclusion criteria and procedures. Of 51 identified weight loss and maintenance strategies, grouped in 14 domains of the Oxford Food and Activity Behaviors taxonomy, the following were the most frequently reported: having healthy foods available at home, regular breakfast intake, increasing vegetable consumption, decreasing sugary and fatty foods, limiting certain foods, and reducing fat in meals. Increased physical activity was the most consistent positive correlate of weight loss maintenance. To our knowledge, this is the first systematic review of information about successful weight loss maintenance obtained from weight control registries. Key common influential characteristics of success were identified, which can inform future prospective studies and weight management initiatives., This study was funded by the Foundation for Science and Technology Portugal (PTDC/DES/72317/2006, 2008-2011).
Published: 2020

21. Champ4life Study Protocol: A One-Year Randomized Controlled Trial of a Lifestyle Intervention for Inactive Former Elite Athletes with Overweight/Obesity

Author: Ruben Francisco, Inês Santos, Luís B. Sardinha, Catarina N. Matias, Cláudia S. Minderico, Filipe Jesus, Paulo Martins, Catarina L Nunes, Marlene N. Silva, Eliana V. Carraça, Miguel Cardoso, Analiza M. Silva, and Repositório da Universidade de Lisboa
Subjects: Gerontology, Male, obesity, Physical fitness, physical activity, 030204 cardiovascular system & hematology, Overweight, law.invention, 0302 clinical medicine, Randomized controlled trial, law, sedentary behavior, Randomized Controlled Trials as Topic, Retirement, Nutrition and Dietetics, biology, Behavior change, Behavior change methods, Middle Aged, Treatment Outcome, Female, medicine.symptom, lcsh:Nutrition. Foods and food supply, Adult, behavior change, Adolescent, former athletes, lcsh:TX341-641, 030209 endocrinology & metabolism, Health Promotion, energy balance regulation, Article, 03 medical and health sciences, Young Adult, medicine, Humans, Resting energy expenditure, Healthy Lifestyle, Exercise, Aged, Athletes, business.industry, biology.organism_classification, medicine.disease, Obesity, business, Risk Reduction Behavior, Food Science
Abstract: © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/)., Preventive and educational programs directed to former elite athletes in the areas of healthy living are required. This is particularly relevant as obesity and health-related problems are observed in retired athletes, especially in those whose current levels of physical activity are below the recommendations. During their sports career, elite athletes are supported by a multidisciplinary team; upon retirement, no support is provided for the transition to a different lifestyle. So far, no program has been implemented to promote sustained healthy lifestyle behaviors in the post-career transition and evidence is lacking for such an intervention. Firstly, we aim to determine if Champ4life, a 1-year lifestyle intervention targeting inactive former athletes with overweight and obesity, is effective for reducing total and abdominal fat. Secondly, our purpose is to assess the effectiveness of the intervention on the levels of physical activity and sedentary behavior, resting energy expenditure, cardio-metabolic markers, physical fitness, energy balance components, eating self-regulation markers, and quality of life over 12 months. Champ4life is an evidence- and theory-based program using a randomized control trial design (intervention vs. control group) that will be conducted on 94 inactive former elite athletes with overweight and obesity. The first four months of the Champ4Life program include a nutritional appointment and 12 weekly, 90-min sessions. Classroom sessions seek to provide participants with key information and a toolbox of behavior change techniques to initiate and sustain long-term lifestyle changes. Participants will undergo baseline, 4-month, and 12-month measurements of body composition (primary outcomes), resting energy expenditure, physical fitness, metabolic markers, energy balance related-markers, and quality of life (secondary outcome). This trial will provide evidence on the effectiveness of the Champ4life program, a pioneer lifestyle intervention for retired athletes, offering tools for sustained changes in physical activity, sedentary behavior and diet, aiming to improve body composition and overall health-related markers., Financial support was provided by Portuguese Institute of Sports and Youth and by International Olympic Committee, under the Olympic Solidarity Promotion of the Olympic Values Unit (Sports Medicine and Protection of Clean Athletes Programme). The current work was also supported by National funding from the Portuguese Foundation for Science and Technology within the R&D units UIDB/00447/2020.
Published: 2019

22. Psychosocial Pretreatment Predictors of Weight Control: A Systematic Review Update

Author: Jutta Mata, Eliana V. Carraça, Inês Santos, and Pedro J. Teixeira
Subjects: Adult, Male, medicine.medical_specialty, Health (social science), Adolescent, Success, 030209 endocrinology & metabolism, lcsh:TX341-641, Body Weight Maintenance, 03 medical and health sciences, Young Adult, 0302 clinical medicine, Behavior Therapy, Physiology (medical), Intervention (counseling), Weight management, Weight Loss, medicine, Body Image, Humans, Psychology, 030212 general & internal medicine, Obesity, Exercise, Life Style, lcsh:RC620-627, Aged, Aged, 80 and over, Motivation, business.industry, Moderators, Weight control, Middle Aged, medicine.disease, Prognosis, Diet, body regions, Weight Reduction Programs, lcsh:Nutritional diseases. Deficiency diseases, Treatment Outcome, Physical therapy, Correlates, Female, Systematic Review, business, Psychosocial, lcsh:Nutrition. Foods and food supply
Abstract: Objective: Systematically identifying pretreatment characteristics that predict successful weight management is important to improve intervention efficacy and clinical practice. This study provides a comprehensive update of a 2005 review on pretreatment predictors of successful weight management. Methods: Results of 37 recent original studies from peer-reviewed journals were merged with the results from the 2005 review. A critical appraisal of the 66 studies included was provided, and meta-analyses were performed when feasible. Results: Fewer previous weight loss attempts were the most consistent pretreatment predictor of successful weight management, although with a small effect size. Importantly, several variables were identified as non-significant predictors of weight loss, showing trivial effects (e.g., eating self-efficacy). Many psychosocial factors remain too little studied to allow reliable conclusions regarding their predictive value. Conclusion: Previous dieting attempts were identified as the soundest predictor of successful weight management. Several factors, previously considered barriers to successful weight management and now identified as non-predictors, require more investigation given the limitations identified in this review. Importantly, due to a comparably thin empirical basis for many predictors, further research is essential to move the field forward. Implications of the current state of research and necessary steps to improve intervention efficacy and clinical practice are discussed
Published: 2018

23. Effects Of Time-restricted Feeding On Supramaximal Exercise Performance: A Randomized And Counterbalanced Crossover Study In Healthy Men

Author: Goncalo V. Mendonca, Cláudia S. Minderico, Inês Santos, Brad J. Schoenfeld, Pedro Pezarat-Correia, and Joana M. Correia
Subjects: medicine.medical_specialty, Physical medicine and rehabilitation, business.industry, Exercise performance, medicine, Time restricted feeding, Physical Therapy, Sports Therapy and Rehabilitation, Orthopedics and Sports Medicine, business, Crossover study
Published: 2021

24. Effects of Time-Restricted Feeding on Supramaximal Exercise Performance and Body Composition: A Randomized and Counterbalanced Crossover Study in Healthy Men

Author: Cláudia S. Minderico, Goncalo V. Mendonca, Joana M. Correia, Brad J. Schoenfeld, Pedro Pezarat-Correia, Inês Santos, and Repositório da Universidade de Lisboa
Subjects: Adult, Male, 0301 basic medicine, Health, Toxicology and Mutagenesis, Physiology, Article, Young Adult, 03 medical and health sciences, 0302 clinical medicine, Intermittent fasting, Exercise performance, medicine, Humans, Time restricted feeding, Wingate test, Regular diet, Exercise, body composition, Cross-Over Studies, training, intermittent fasting, business.industry, Public Health, Environmental and Occupational Health, Fasting, 030229 sport sciences, Crossover study, 030104 developmental biology, Medicine, medicine.symptom, Energy Intake, business, Body mass index, Dieting
Abstract: © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/)., Using a crossover design, we explored the effects of both short- and long-term time-restricted feeding (TRF) vs. regular diet on Wingate (WnT) performance and body composition in well-trained young men. Twelve healthy male physical education students were included (age: 22.4 ± 2.8 years, height: 174.0 ± 7.1 cm, body mass: 73.6 ± 9.5 kg, body mass index: 24.2 ± 2.0 kg/m2). The order of dieting was randomized and counterbalanced, and all participants served as their own controls. TRF was limited to an 8-h eating window and non-TRF involved a customary meal pattern. Participants performed WnT tests and body composition scans at baseline, post-one and post-four weeks of the assigned diet. Before testing, participants were asked to fill out a dietary record over four consecutive days and were instructed to continue their habitual training throughout the study. Energy intake and macronutrient distribution were similar at baseline in both conditions. WnT mean power and total work output increased post-four weeks of TRF. Both conditions were similarly effective in increasing fat-free mass after four weeks of intervention. However, there was no correlation between change in fat-free mass and WnT mean power after TRF. TRF did not elicit any changes in WnT performance or body composition one week post-intervention. Thus, long-term TRF can be used in combination with regular training to improve supramaximal exercise performance in well-trained men., This work was partly supported by the Fundação para a Ciência e Tecnologia, under Grant UIDB/00447/2020 to CIPER—Centro Interdisciplinar para o Estudo da Performance Humana (unit 447) and by Universidade de Lisboa (grant attributed to J.M.C.-n C00246e).
Published: 2021

25. Rice husk cement-based composites for acoustic barriers and thermal insulating layers

Author: Julieta António, Beatriz Marques, Micaela Oliveira, João Almeida, Maria Inês Santos, Jorge de Brito, and António Tadeu
Subjects: Cement, Materials science, business.industry, 0211 other engineering and technologies, 02 engineering and technology, Building and Construction, engineering.material, Husk, Durability, Thermal conductivity, Coating, Natural rubber, Mechanics of Materials, Thermal insulation, visual_art, 021105 building & construction, Architecture, Thermal, engineering, visual_art.visual_art_medium, 021108 energy, Composite material, Safety, Risk, Reliability and Quality, business, Civil and Structural Engineering
Abstract: This work evaluates the performance of cement-based composites made with rice husk and intended to be used in acoustic barriers and as thermal insulating material in a multilayer system. Because acoustic barriers are exposed to external conditions and mechanical loads, a wide range of laboratory tests were performed to evaluate the mechanical, durability and acoustic characteristics of the composites. Their specific heat capacity and thermal conductivity were evaluated when used as an insulation layer . Other cement-based composites that incorporate treated wood and rubber granules were studied for comparison purposes. The environmental performance of these new cement-based composites was evaluated by means of a life cycle assessment (LCA). It was found that those that contain rice husk are suitable for coating acoustic barriers, since it offers a good mechanical, durability, and acoustic performance . It was also found that rice husk cement-based composites can be used as thermal insulation layer. The LCA further demonstrated the good performance of the rice husk composites compared with those containing treated wood and rubber granules.
Published: 2021

26. Lower Gastrointestinal Bleeding Associated With Sodium Polystyrene Sulfonate Use

Author: Eduardo Dantas, Inês Santos, Ricardo Freire, Ana Paula Oliveira, Cláudio Martins, C Sequeira, Claudia R.L. Cardoso, and Mariana Coelho
Subjects: medicine.medical_specialty, Cirrhosis, Lower gastrointestinal bleeding, medicine.diagnostic_test, Hyperkalemia, Colon, business.industry, Acute kidney injury, Colonoscopy, Case Report, General Medicine, medicine.disease, Gastroenterology, Hematochezia, 03 medical and health sciences, 0302 clinical medicine, 030220 oncology & carcinogenesis, Internal medicine, medicine, 030211 gastroenterology & hepatology, Decompensation, medicine.symptom, Sodium Polystyrene Sulfonate, business
Abstract: Sodium polystyrene sulfonate (kayexalate) is a cation-exchange resin widely used in the management of hyperkalemia. Gastrointestinal adverse events are uncommon; symptoms are nonspecific, and mucosal injury can range from mild ulceration to bowel perforation. An 81-year-old man was admitted because of decompensation of cirrhosis with acute kidney injury and hyperkalemia, treated with sodium polystyrene sulfonate. During admission, he presented multiple episodes of hematochezia, accompanied by tachycardia and hemoglobin drop. Colonoscopy revealed colonic ulceration, and histopathological findings were compatible with ulceration due to kayexalate injury. Despite rare, the widespread use of sodium polystyrene sulfonate puts a large population at risk of serious complications related to its use.
Published: 2021

27. ENERGY AND SUSTAINABLE PERFORMANCE OF A MULTIFUNCTIONAL FAÇADE

Author: Michael Brett, Nuno Simões, Sérgio Fernando Tadeu, Inês Santos, I. Simões, and Hélder Silva
Subjects: Architectural engineering, Engineering, business.industry, Facade, business, Energy (signal processing)
Published: 2019

28. Behavioural and psychological pretreatment predictors of short- and long-term weight loss among women with overweight and obesity

Author: Rita Tomás, Pedro J. Teixeira, Vitor Hugo Teixeira, Eliana V. Carraça, Inês Santos, Rui Jorge, Marlene N. Silva, and Faculdade de Ciências da Nutrição e Alimentação
Subjects: 050103 clinical psychology, 030309 nutrition & dietetics, Overweight, law.invention, 03 medical and health sciences, Quality of life, Randomized controlled trial, law, Weight loss, Weight management, Weight Loss, Medicine, Humans, 0501 psychology and cognitive sciences, Obesity, Exercise, 0303 health sciences, business.industry, 05 social sciences, Weight change, Health sciences, Medical and Health sciences, Ciências médicas e da saúde, medicine.disease, Psychiatry and Mental health, Clinical Psychology, Locus of control, Medical and Health sciences, Quality of Life, Female, Ciências da Saúde, Ciências médicas e da saúde, medicine.symptom, business, Demography
Abstract: This study aims at identifying behavioural and psychological pretreatment predictors of 12- and 36-month weight loss in women with overweight/obesity enrolled in a behavioural weight management intervention. A sample of 221 women participated in a randomized controlled trial on weight management (n12 month = 184; n36 month = 156). Multiple linear regressions were used to identify pretreatment predictors of successful weight loss, separately for intervention and control groups. Completers-only and baseline observation carried forward analyses were performed. This study is a secondary analysis of data from the ‘Promotion of Exercise and Health in Obesity’ randomized controlled trial. Fewer weight loss attempts in the last year positively predicted weight loss at 12 months in the intervention group, explaining 6% of the variance. At 36 months, in the intervention group, 20.2% of the variance in weight change was explained by lower eating disinhibition and higher weight-related quality of life in completers-only analyses, while baseline observation carried forward analyses explained only 9.8% of the variance in weight change via higher self-esteem and lower weight loss expectations. In the control group, higher exercise self-efficacy and a more internal weight locus of control predicted weight loss at 36 months, explaining 13.9% of the variance (completers-only analyses). Previous weight loss attempts were identified as the most efficient pretreatment predictor of 12-month weight loss. Eating disinhibition, weight-related quality of life, self-esteem, weight loss expectations, exercise self-efficacy, and weight locus of control seem to be key factors for long-term success. Level I, randomized controlled trial. ClinicalTrials.gov identifier NCT00513084.
Published: 2019

29. THU0403 AXIAL SPONDYLOARTHRITIS INDUCES MUSCLE DISFUNCTION, THE ROLE OF BODY COMPOSITION PARAMETERS: MYOSPA STUDY

Author: Inês Santos, Santiago Rodrigues-Manica, Jaime Branco, Carolina Lage Crespo, Rita Amador, Rita Pinheiro Torres, Conceição Calhau, Sofia Ramiro, Agna Neto, Alexandre Sepriano, Diana Teixeira, Maria Luisa Sequeira, Lucia Domingues, and Fernando P. Santos
Subjects: medicine.medical_specialty, business.industry, Body water, medicine.disease, Internal medicine, Sarcopenia, Lean body mass, Medicine, Axial spondyloarthritis, business, BASFI, Bioelectrical impedance analysis, Body mass index, BASDAI
Abstract: Background: Sarcopenia as well as abnormalities in body composition are common features in several chronic diseases and have been shown to lead to increased morbidity and mortality. However, their assessment in young patients with axial spondyloarthritis (axSpA) has not been performed thus far. Objectives: To assess the skeletal muscle mass, strength and performance as well as body composition in patients with axSpA compared to healthy controls. Methods: Patients between 18 and 50 years of age with the diagnosis of axSpA and short disease duration (under 10 years) and classified according to the ASAS criteria were included. Healthy individuals matched by gender and age (1:1) were used as control group. Muscle strength (MS) was assessed by resisted flexion of the dominant forearm using a hand dynamometer. Muscle performance was assessed with the 60 second sit-to-stand test (STS60) and with 5 times sit-to-stand test (STS5). Body composition was assessed with octapolar multifrequency bioelectrical impedance analysis (InBody 770). The level of physical activity was measured by the IPAQ questionnaire. BASDAI and BASFI were used to evaluated disease activity and function, respectively. All measures (except age and disease duration) are reported as median and 25th and 75th percentiles. Non-parametric tests were used to compare groups. Results: A total of 27 patients and 27 controls were included [mean age (36.5 ± SD 1.0), 66% males]. AxSpA patients had symptom duration of 7.0 ± SD 0.9 years, BASDAI 2.7 (1.4-3.6) and BASFI 0.9 (0.3-3.2). Compared to controls, axSpA patients had less MS in the dominant upper limb (DUL) (46.0 (37.5-70.6) vs 71.2 (54.1-83.4) kg, p=0.006) and worse performance on the STS60 test (48.0 (27.5-64.3) vs 63.0 (53.0-68.0) repetitions, p=0.010). These differences were maintained after normalization for lean mass (LM) (MS_DUL/LM_DUL and STS60/Total_LM). In addition, compared to controls, axSpA patients had higher body fat (BF) (19.8 (12.1-29.1) vs 15.7 (10.1-22.2) kg, p=0.041), torso fat (TF) (10.3 (6.3-15.9) vs 8.1 (5.1-11.1) kg, p=0.450) and visceral fat (VF) (87.3 (52.7-145.1) vs 65.4 (41.8-96.4) cm2, p=0.034). No differences were registered for weight, body mass index, total body water, extracellular water, fat free mass, LM and bone mineral content between groups. The level of physical activity, measured by the IPAQ questionnaire, was identical between patients and healthy controls (p=0.500). Conclusion: Compared to healthy controls, young axSpA patients have a reduction in muscle strength and muscle performance with maintenance of muscle mass and levels of physical activity. These preliminary results underline the relevance of further investigations. *Values are median (IQR) unless otherwise indicated. Comparison between patients and controls tested by paired samples t-test unless otherwise indicated. §Comparison between patients and controls tested by Chi-Square test in Gender and Physical Activity variables. Disclosure of Interests: Maria Luisa Sequeira: None declared, Ines da Costa Santos: None declared, Rita Amador: None declared, Lucia Domingues: None declared, Carolina Crespo: None declared, Santiago Rodrigues-Manica Grant/research support from: Novartis, MSD, Speakers bureau: Novartis, Sofia Ramiro Grant/research support from: MSD, Consultant for: AbbVie, Lilly, MSD, Novartis, Pfizer, Sanofi, Speakers bureau: AbbVie, Lilly, MSD, Novartis, Pfizer, Sanofi, Alexandre Sepriano: None declared, Diana Teixeira: None declared, Agna Neto: None declared, Rita Pinheiro Torres: None declared, Conceicao Calhau: None declared, Jaime Branco: None declared, Fernando Pimentel dos Santos Grant/research support from: From Abbvie and Novartis, Speakers bureau: Abbvie, Novartis, Pfizer, Biogen
Published: 2019

30. Does diet strictness level during weekends and holiday periods influence 1-year follow-up weight loss maintenance? Evidence from the Portuguese Weight Control Registry

Author: Inês Santos, Vitor Hugo Teixeira, Rui Jorge, Pedro J. Teixeira, and Faculdade de Ciências da Nutrição e Alimentação
Subjects: Male, 0301 basic medicine, Health Behavior, Medicine (miscellaneous), Body Mass Index, Body Weight Maintenance, 0302 clinical medicine, Weight loss, Weight management, Odds Ratio, Registries, lcsh:RC620-627, Holidays, Nutrition and Dietetics, Middle Aged, humanities, Weight Reduction Programs, lcsh:Nutritional diseases. Deficiency diseases, Diet strictness, Medical and Health sciences, language, Female, medicine.symptom, lcsh:Nutrition. Foods and food supply, Dieting, Adult, education, Short Report, lcsh:TX341-641, 030209 endocrinology & metabolism, Clinical nutrition, Weight loss maintenance, 03 medical and health sciences, Weight Loss, medicine, Humans, 030109 nutrition & dietetics, Portugal, business.industry, Health sciences, Medical and Health sciences, Weight change, Ciências médicas e da saúde, Weight control, Weekends, language.human_language, Diet, Regimen, Ciências da Saúde, Ciências médicas e da saúde, Portuguese, business, human activities, Follow-Up Studies, Demography
Abstract: There is not much evidence about how diet strictness during weekends and holidays influence long-term weight loss maintenance. Our aim was to examine how dieting more or less strictly during weekends and holidays (vs. weekdays and non-holiday periods) influence weight loss maintenance. Participants (n = 108) from the Portuguese Weight Control Registry indicated whether they had a more or less strict diet regimen during weekends compared to weekdays. A similar question about holiday and non-holiday period’ diet regimen was answered. Weight and height were measured at baseline and 1y follow-up. A 3% maximum weight variation defined participants as “non-regainers”. General level on dieting strictness on weekends vs. weekdays (r = − 0.28, p
Published: 2019

31. Environmental performance of a cork-based modular living wall from a life-cycle perspective

Author: Andreia Cortês, António Tadeu, João Almeida, Maria Inês Santos, Carlos Manuel Silva, and Jorge de Brito
Subjects: Environmental Engineering, Geography, Planning and Development, 0211 other engineering and technologies, Biomass, 02 engineering and technology, 010501 environmental sciences, Carbon sequestration, Cork, engineering.material, 01 natural sciences, Festuca glauca, Thermal insulation, Environmental impact assessment, 021108 energy, 0105 earth and related environmental sciences, Civil and Structural Engineering, biology, business.industry, Environmental engineering, Building and Construction, Vegetation, biology.organism_classification, engineering, Environmental science, Facade, business
Abstract: In a previous work, the authors of this paper proposed a new modular living wall made with expanded cork agglomerate, fully describing the designing process and discussing the overall mechanical performance. It was then shown that several key environmental and functional requirements were met by favouring the use of insulation cork board (ICB), a thermal insulation material with low environmental impact and good water retention. In this paper, the authors have extended the characterization of that living wall system to assess its performance under real conditions, with different plant species, geographical orientations and seasons. For this purpose, a prototype was built with four facades, facing north, south, east, and west. The area of facade covered by vegetation and the carbon sequestration provided by two different plant species were then monitored for over a year. Annual values of carbon uptake, experimentally determined, were further used to update an environmental life cycle model of the system. The results suggest that this modular living wall performs well in terms of plant development and carbon sequestration, with Festuca glauca showing a higher cumulative carbon uptake and a higher percentage of facade coverage than Thymus pulegioides, regardless of the geographical orientation and season. This essentially results from the greater amount of biomass produced by Festuca glauca and its hanging behaviour. It was also concluded that this new modular living wall is an eco-friendly choice, when assessed from a life cycle perspective, since it has a negative carbon balance over its life cycle (22.7 kg CO2eq per square meter).
Published: 2021

32. Innovative module of expanded cork agglomerate for green vertical systems

Author: António Tadeu, Andreia Cortês, João Almeida, Maria Inês Santos, and Jorge de Brito
Subjects: Environmental Engineering, business.industry, Geography, Planning and Development, 0211 other engineering and technologies, Functional requirement, 02 engineering and technology, Building and Construction, 010501 environmental sciences, Modular design, Cork, engineering.material, 01 natural sciences, Manufacturing engineering, Work (electrical), Sustainability, engineering, Environmental science, 021108 energy, Urban heat island, business, Engineering design process, Air quality index, 0105 earth and related environmental sciences, Civil and Structural Engineering
Abstract: Green vertical systems (GVSs) can offer several benefits, both for buildings by increasing their thermal and acoustic insulation, and for the urban environment by enhancing the biodiversity, improving the air quality, and reducing the heat island effect. Despite all these benefits, the effective sustainability of these systems has been questioned when assessed from a life cycle perspective. This is largely because of the environmental impacts related to the components and materials used in the construction of such solutions, but also due to irrigation and maintenance needs. In this work, the authors describe the design process for a new modular GVS based on insulation cork boards (ICBs). A comparative life cycle analysis (LCA) of several GVSs was first carried out to identify the environmental hotspots of most concern related to the product phase. Based on the conclusions of the LCA and a set of additional functional requirements, the authors then proposed a new ICB module to build a GVS with better environmental performance. Since ICBs can be produced with different mass densities, with distinct environmental impacts and manufacturing costs, a full mechanical characterization was also carried out to assist in choosing the most suitable ICB density. The results suggest that ICB modules of medium density (140–160 kg/m3) can be an appropriate eco-friendlier alternative to current plastic- and metal-based GVSs, fully complying with the environmental and functional requirements that would be expected for a living wall system.
Published: 2021

33. Weight control behaviors of highly successful weight loss maintainers: the Portuguese Weight Control Registry

Author: Marlene N. Silva, Paulo Nuno Vieira, Pedro J. Teixeira, Inês Santos, and Luís B. Sardinha
Subjects: Adult, Male, 0301 basic medicine, Gerontology, Health Behavior, Physical activity, 030209 endocrinology & metabolism, Portion size, 03 medical and health sciences, 0302 clinical medicine, Weight loss, Weight maintenance, Weight Loss, medicine, Humans, Registries, Exercise, General Psychology, 030109 nutrition & dietetics, Portugal, business.industry, Dietary intake, Body Weight, Weight control, Middle Aged, Diet, Psychiatry and Mental health, Cross-Sectional Studies, Female, medicine.symptom, Energy Intake, business, Demography
Abstract: To describe key behaviors reported by participants in the Portuguese Weight Control Registry and to determine associations between these behaviors and weight loss maintenance. A total of 388 adults participated in this cross-sectional study. Assessments included demographic information, weight history, weight loss and weight maintenance strategies, dietary intake, and physical activity. Participants lost on average 18 kg, which they had maintained for ~28 months. Their average dietary intake was 2199 kcal/day, with 33 % of energy coming from fat. About 78 % of participants engaged in levels of moderate-plus-vigorous physical activity exceeding 150 min/week (51 % above 250 min/week), with men accumulating 82 more minutes than women (p
Published: 2016

34. Body weight variability is not associated with changes in risk factors for cardiometabolic disease

Author: Sofus C. Larsen, R. James Stubbs, Cristiana Duarte, Jack K. Olsen, Jake Turicchi, Ruairi O'Driscoll, Inês Santos, António L. Palmeira, Graham W. Horgan, Jorge Encantado, and Berit L. Heitmann
Subjects: lcsh:Diseases of the circulatory (Cardiovascular) system, Diastole, Context (language use), 030204 cardiovascular system & hematology, Body weight, Weight cycling, law.invention, 03 medical and health sciences, 0302 clinical medicine, Randomized controlled trial, Weight loss, law, Linear regression, Internal Medicine, medicine, 030212 general & internal medicine, business.industry, Weight change, Weight variability, 3. Good health, Cardiometabolic disease, Blood pressure, lcsh:RC666-701, medicine.symptom, Cardiology and Cardiovascular Medicine, business, Research Paper, Demography
Abstract: Context Weight loss is known to improve health, however the influence of variability in body weight around the overall trajectory on these outcomes is unknown. Few studies have measured body weight frequently enough to accurately estimate the variability component. Objective To investigate the association of 12-month weight variability and concurrent weight change with changes in health markers and body composition. Methods This study was a secondary analysis of the NoHoW trial, a 2 × 2 factorial randomised controlled trial promoting evidence-based behaviour change for weight loss maintenance. Outcome measurements related to cardiometabolic health and body composition were taken at 0, 6 and 12 months. Participants were provided with Wi-Fi connected smart scales (Fitbit Aria 2) and asked to self-weigh regularly over this period. Associations of weight variability and weight change with change in outcomes were investigated using multiple linear regression with multiple levels of adjustment in 955 participants. Results Twelve models were generated for each health marker. Associations between weight variability and changes in health markers were inconsistent between models and showed no evidence of a consistent relationship, with all effects explaining, Highlights • Previous longitudinal investigations suggest that variability is a risk factor for obesity-related diseases. • We tested whether 12-month variability impacted traditional markers of disease. • No association between weight variability and any risk factor was found. • Weight loss consistently improved health independent of the degree of variability. • The mechanism linking long-term variability to risk of disease remains unclear.
Published: 2020

35. ADEQUACY OF TRAINING IN ADOLESCENT HEALTH: OPINIONS OF FAMILY PHYSICIANS AND NURSES WHO ATTENDED A TRAINING COURSE

Author: Maria Inês Santos, Elisabete Santos, and Frederico Rosário
Subjects: medicine.medical_specialty, education.field_of_study, MEDICINE::Social medicine::Public health medicine research areas::Family medicine [Research Subject Categories], business.industry, SOCIAL SCIENCES::Social sciences::Education::Nursing education [Research Subject Categories], education, Population, Primary care, SOCIAL SCIENCES::Other social sciences::Public sector research [Research Subject Categories], Family medicine, SOCIAL SCIENCES::Social sciences::Pedgogical work [Research Subject Categories], medicine, General Earth and Planetary Sciences, Training needs, Observational study, Substance use, Descriptive research, business, General Environmental Science, Adolescent health, Graduation
Abstract: Objetivos: Avaliar a perceção que os profissionais de saúde dos cuidados de saúde primários têm sobre a formação recebida em saúde do adolescente e identificar as limitações sentidas e as necessidades de formação adicional. Tipo de estudo: Estudo observacional, transversal e descritivo. Local: Região Centro. População: Médicos e enfermeiros de família da região Centro. Métodos: Os médicos e enfermeiros de família inscritos numa formação de saúde do adolescente foram convidados a responder a um inquérito em que se solicitava a avaliação da sua formação pré e pós-graduada em saúde do adolescente, a necessidade de receber formação adicional e as limitações. Resultados: A maioria dos participantes considerou que a sua formação pré-graduada era insuficiente (médicos: 97%; enfermeiros: 77,2%) e que não se sentia apto para lidar com adolescentes após a licenciatura (médicos: 93,9%; enfermeiros: 87,7%). A maioria dos médicos de família também considerou insuficiente a formação recebida durante o internato (77,5%), não se sentindo aptos a lidar com adolescentes no final do mesmo (68,4%), tendo ainda considerado insuficiente a formação frequentada após o internato (73,0%). Os participantes consideraram ter necessidade de receber formação adicional em saúde do adolescente, apontando áreas com maiores necessidades formativas: as queixas psicossomáticas (82,2%), os problemas familiares (72,9%), a entrevista ao adolescente (69,5%), o consumo de substâncias (62,6%) e os problemas escolares e de comportamento (62,3%). Conclusões: Os médicos e enfermeiros de família inquiridos referiram sentir importantes lacunas formativas em saúde do adolescente na sua formação pré e pós-graduada, bem como a necessidade de obter mais formação nesta área. info:eu-repo/semantics/publishedVersion
Published: 2018

36. Improving the attitudes of primary care practitioners toward adolescent care : a pre-post intervention pilot study

Author: Maria Inês Santos, Frederico Rosário, Alzira Ferrão, Elisabete Santos, and Repositório da Universidade de Lisboa
Subjects: Adolescent care, MEDICINE::Social medicine::Public health medicine research areas::Family medicine [Research Subject Categories], medicine.medical_specialty, Psychological intervention, Adolescent health, Subgroup analysis, Continuing medical education, Adolescents, Post-intervention, 03 medical and health sciences, 0302 clinical medicine, 030225 pediatrics, Intervention (counseling), Medicine, 030212 general & internal medicine, Primary health care, business.industry, Public Health, Environmental and Occupational Health, MEDICINE::Dermatology and venerology,clinical genetics, internal medicine::Internal medicine::Paediatric medicine [Research Subject Categories], Scale (social sciences), Family medicine, Attitudes, Pediatrics, Perinatology and Child Health, business, Barriers
Abstract: © 2018 Walter de Gruyter GmbH, Berlin/Boston., Background: Investing in adolescent health is among the most cost-effective health measures. Primary care practitioners are ideally positioned to deliver such interventions. However, several barriers hinder them from engaging with adolescents. Objective: To pilot test the impact of a 1-day training session on adolescent health on the attitudes of primary care practitioners toward adolescent care. Subjects: Participants were family physicians and nurses enrolled in a 1-day training session on adolescent health. Methods: A non-randomized, pre-post intervention study with no control group. Data on barriers for providing care to adolescents, preferred pediatric age group and attitudes toward adolescent care were collected immediately prior. Participants’ attitudes were measured again immediately after training. Results: Most participants reported they preferred to attend pediatric groups other than adolescents. The most frequently reported barriers were: excessive amount of time needed and lack of training. Participants reported positive pre-training attitudes, with mean scores above the midpoint of the scale in all dimensions. Significant positive improvements were observed after training in Adequacy, Self-esteem and Satisfaction. Subgroup analysis showed that at baseline, professionals who preferred to work with adolescents had significantly more positive attitudes in Adequacy, Self-esteem and Satisfaction. After training there was a general improvement in attitudes in both groups, with attenuation of the differences between them. Conclusion: Participation in a 1-day tailored educational intervention on adolescent health had a positive impact on the attitudes of primary care practitioners, regardless of their preferred age group. This improvement may lead to more active engagement with adolescents and substantial health gains.
Published: 2018

37. Nanoparticulate platforms for targeting bone infections: meeting a major therapeutic challenge

Author: Ana Bettencourt, Inês Santos-Ferreira, and António J. Almeida
Subjects: Drug, medicine.medical_specialty, Therapeutic effectiveness, medicine.drug_class, media_common.quotation_subject, Antibiotics, Biomedical Engineering, Medicine (miscellaneous), Bioengineering, Context (language use), Development, Pharmacology, Bone Infection, Drug Delivery Systems, Humans, Nanotechnology, Medicine, General Materials Science, Intensive care medicine, media_common, Drug Carriers, Controlled release drug, business.industry, Anti-Bacterial Agents, Systemic toxicity, Delayed-Action Preparations, Nanoparticles, Bone Diseases, Drug carrier, business
Abstract: Bone infections are devastating complications in orthopedics due to biofilm formation. Treatment requires high antibiotic doses, which may lead to systemic toxicity thus limiting the drug therapeutic effectiveness. In this context, nanoparticles are well-known controlled release drug carriers that are able to modulate release rate, versatile in terms of administration routes and may be used as local delivery systems. Regarding bone infections, although nanoparticles are a promising strategy for overcoming biofilm tolerance, there are clearly technical, safety, regulatory and clinical challenges that need to be overcome before such nanomedicines may be translated into clinical use. In this paper, we present a critical overview on the high expectations against the real potential of the nanotechnological approaches to bone infection treatment.
Published: 2015

38. Predicting long-term weight loss maintenance in previously overweight women: A signal detection approach

Author: Luís B. Sardinha, Marlene N. Silva, Pedro J. Teixeira, Inês Santos, and Jutta Mata
Subjects: medicine.medical_specialty, Nutrition and Dietetics, business.industry, Endocrinology, Diabetes and Metabolism, Medicine (miscellaneous), Overweight, law.invention, Endocrinology, Randomized controlled trial, Poor body image, law, Weight loss, Predictive value of tests, Weight management, Physical therapy, Intrinsic motivation, Medicine, Signal Detection Analyses, medicine.symptom, business
Abstract: Objective Examine psychological and behavioral predictors of 3-year weight loss maintenance in women. Methods Participants were 154 women in a 1-year randomized controlled trial on weight management with a 2-year follow-up. Signal detection analyses identified behavioral and psychological variables that best predicted 5% and 10% weight loss at 3 years. Results Women with better body image were more likely to have lost ≥5% weight at 3 years (P
Published: 2015

39. The NoHoW protocol

Author: Marja Harjumaa, Elina Mattila, Sarah E. Scott, Beth Pearson, Carol Stalker, Elizabeth H. Evans, Kirby Sainsbury, Berit L. Heitmann, Lauren Ramsey, Graham W. Horgan, Jorge Encantado, R. James Stubbs, Marie-Louise K Mikkelsen, Cristiana Duarte, António L. Palmeira, Falko F. Sniehotta, Marta M. Marques, Marcela Matos, Inês Santos, Pedro J. Teixeira, and Sofus C. Larsen
Subjects: Male, Cost-Benefit Analysis, Psychological intervention, Body Weight Maintenance, law.invention, 0302 clinical medicine, Randomized controlled trial, law, Weight loss, Protocol, Multicenter Studies as Topic, 030212 general & internal medicine, Randomized Controlled Trials as Topic, Activity tracker, Behaviour change, General Medicine, Mobile Applications, 3. Good health, Weight Reduction Programs, Evidence-Based Practice, Body Composition, Self-regulation, Female, Public Health, medicine.symptom, Digital health, Adult, medicine.medical_specialty, Evidence-based practice, BF, 030209 endocrinology & metabolism, Weight loss maintenance, Self-Control, 03 medical and health sciences, SDG 3 - Good Health and Well-being, Weight Loss, medicine, Humans, Exercise, Motivation, business.industry, Emotion regulation, medicine.disease, Obesity, Emotional Regulation, Physical therapy, business, Body mass index
Abstract: IntroductionObesity and associated diseases place a severe burden on healthcare systems. Behavioural interventions for weight loss (WL) are successful in the short term but often result in weight regain over time. Self-regulation of eating and activity behaviours may significantly enhance weight loss maintenance (WLM) and may be effectively augmented by contextual behavioural approaches to emotion regulation. The NoHoW trial tests the efficacy of a theoretically informed, evidence-based digital toolkit using a mobile-enabled website, activity trackers and Wi-Fi scales for WLM aiming to target (1) self-regulation and motivation, and (2) emotion regulation in adults who achieved clinically significant (≥5%) WL in the previous 12 months (initial body mass index (BMI) ≥25 kg/m2).Methods and analysisThe study is an 18-month, 3-centre, 2×2 factorial single-blind, randomised controlled trial, which recruited 1627 participants achieving ≥5% WL between March 2017 and March 2018. Participants are randomly allocated to one of four arms: (1) self-monitoring only (self-weighing and activity tracker), (2) self-regulation and motivation, (3) emotion regulation or (4) combined self-regulation, motivation and emotion regulation. Participants attend four clinical investigation days at 0, 6, 12 and 18 months and are instructed to use the digital toolkit for 18 weeks during the first 6 months and at their discretion for the remaining 12 months. The primary outcome is change in weight (kg) at 12 months from baseline. Secondary outcomes are body composition (eg, bioimpedance analysis), health biomarkers (glycated haemoglobin, lipids, blood pressure, hair cortisol), dietary intake, physical activity, sleep, motivational, self-regulatory, emotion regulatory moderators/mediators of WLM, engagement, user experience, acceptability and cost-effectiveness of the interventions.Ethics and disseminationEthical approval was granted by Institutional Ethics Committees at the Universities of Leeds (17–0082; 27 February 2017), Lisbon (17/2016; 20 February 2017) and Capital Region of Denmark (H-16030495, 8 March 2017). Results will be published in scientific journals.Trial registration numberISRCTN88405328.
Published: 2019

40. Poster Sessions

Author: Kanishka Nilaweera, Brian Power, Aleksander Owczarek, Olga Molinero, Maria João Gouveia, Eneko Larumbe-Zabala, Tomasz Stefaniak, Inês Santos, Filipa Teixeira, Akheel Syed, Feng TAO, and Roberta Frontini
Subjects: Gerontology, 0303 health sciences, 03 medical and health sciences, 0302 clinical medicine, Health (social science), 030309 nutrition & dietetics, business.industry, Physiology (medical), Medicine, 030209 endocrinology & metabolism, business, Term (time)
Published: 2013

41. E-MAIL AS A COMMUNICATION AND LEARNING TOOL: E-MAIL MESSAGES FROM CHINESE STUDENTS STUDYING IN PORTUGAL TO THEIR TEACHERS

Author: Marta Filipe Alexandre, Inês Santos, and Luís Filipe Barbeiro
Subjects: Engineering, Multimedia, business.industry, business, computer.software_genre, computer
Published: 2016

42. Estado de mal convulsivo na urgência pediátrica: estudo retrospectivo de cinco anos

Author: Hipólito Nzwalo, Maria Inês Santos, José Paulo Monteiro, and Maria José Fonseca
Subjects: Psychomotor learning, medicine.medical_specialty, Pediatrics, business.industry, Retrospective cohort study, General Medicine, Status epilepticus, medicine.disease, Developmental disorder, Epilepsy, Epidemiology, medicine, Etiology, Observational study, medicine.symptom, business
Abstract: Introdução/Objectivos: O estado de mal epiléptico (EME) é a emergência neurológica mais comum na infância. Pode associar-se a mortalidade e morbilidade elevadas, traduzida em défices neurológicos focais, perturbação do desenvolvimento e epilepsia. Os objectivos deste estudo foram descrever a epidemiologia, a mortalidade e morbilidade do EME convulsivo e avaliar os fatores preditivos do seu prognóstico neurológico, cognitivo e comportamental. Material e Métodos: Estudo observacional, retrospectivo e analítico. Foram analisados os processos clínicos das crianças admitidas na Urgência Pediátrica do Hospital Garcia de Orta com diagnóstico de EME convulsivo entre um de Janeiro 2002 a 31 de Dezembro 2006. As variáveis estudadas foram: idade na crise e idade atual, sexo, tipo de crise epiléptica, duração e etiologia da crise epiléptica, défice neurológico, epilepsia, crises epilépticas, desenvolvimento psicomotor e comportamento. Relativamente às últimas cinco variáveis foram analisados os dados prévios e posteriores ao episódio de EME. O tratamento dos dados foi efectuado com os programas Excel2007® e SPSS 15.0®. Resultados: Foram admitidas 29 crianças, com 33 episódios de EME com idades compreendidas entre os nove meses e os cinco anos, não foram encontradas diferenças na distribuição entre sexos (masculino: 12; feminino: 17 – p = 0,46). A etiologia do EME foi febril em 16 crianças, sintomática remota em sete, relacionada com epilepsia idiopática/criptogénica em cinco crianças e não classificável em um caso. O tempo médio de seguimento foi de seis anos e quatro meses. Não se verificaram mortes associadas ao EME. Verificou-se deterioração do estado neurológico prévio em duas crianças (8,7%). Foi diagnosticada epilepsia subsequente ao EME em três (13%) crianças. Conclusões: Esta revisão retrospectiva sugere que o EME está associado a um melhor prognóstico do que o registado há algumas décadas atrás. Verificou-se uma evolução mais favorável no estado de mal febril relativamente às outras etiologias.
Published: 2012

43. Causas e consequências da variabilidade da hemoglobina glicada numa população pediátrica

Author: Joana Campos, Cecília Figueiredo, Frederico Rosário, Maria Inês Santos, Graça Carvalho, and Catarina Resende
Subjects: medicine.medical_specialty, education.field_of_study, business.industry, Cross-sectional study, Population, General Medicine, medicine.disease, Surgery, chemistry.chemical_compound, chemistry, Statistical significance, Diabetes mellitus, Internal medicine, Metabolic control analysis, Medicine, Microalbuminuria, Glycated hemoglobin, business, education, Dyslipidemia
Abstract: Type one diabetes mellitus is the second most frequent disease in childhood, presenting with serious complications when inadequately controlled. The most useful measure of metabolic control is hemoglobin A1c (HbA1c), being essential the awareness of the causes of its variability.to evaluate the effect of age and time of disease on HbA1c; to evaluate the relationship between HbA1c and serum lipid and microalbuminuria values.Observational, transversal and analytic study, based on data obtained in the files of all patients that attain the Pediatric Diabetic Consult. The studied variables were: sex, actual age, diagnostic age, metabolic control and chronic complications. Statistical analysis was made with Excel2003® and SPSS 15.0®. A significance level of 5% was adopted. Results: a 96 diabetic population was obtained. Last year HbA1c average was 8,3% and was less than 7,5% in one third of the cases. Adolescent's HbA1c (8,4%) was significantly higher than in children (7,8%) (p=0,03). Diabetics with a disease longer than five years presented higher HbA1c values (9% vs. 7,8%; p
Published: 2012

44. Metformin effectiveness and safety in the management of overweight/obese nondiabetic children and adolescents: metabolic benefits of the continuous exposure to metformin at 12 and 24 months

Author: Laura Oliveira, Pedro Marques, Catarina Limbert, Maria Inês Santos, and Lurdes Lopes
Subjects: medicine.medical_specialty, business.industry, Public Health, Environmental and Occupational Health, nutritional and metabolic diseases, 030209 endocrinology & metabolism, Overweight, medicine.disease, Obesity, Childhood obesity, Metformin, 03 medical and health sciences, 0302 clinical medicine, Insulin resistance, Weight loss, Internal medicine, Pediatrics, Perinatology and Child Health, medicine, Physical therapy, 030212 general & internal medicine, medicine.symptom, business, Adverse effect, Body mass index, medicine.drug
Abstract: Introduction: Childhood obesity prevalence is rising and new therapeutical approaches are needed. Metformin is likely beneficial in obese and/or insulin-resistant children/adolescents, but its role in this setting is still unclear. We aimed to evaluate the effectiveness, in terms of weight loss and insulin resistance, and safety of metformin in nondiabetic overweight/obese children and adolescents. Methods: We retrospectively reviewed clinical records of 78 nondiabetic obese/overweight [body mass index (BMI)≥85th/95th percentile for age and sex] children and adolescents. Anthropometric and metabolic outcomes of 39 patients treated with metformin (mean daily dose: 1.3±0.5 g) were analyzed and compared to lifestyle intervention alone at different follow-up times (12 and 24 months). Results: The mean age of the 78 patients was 13.3 years, 41 were females and mean BMI and BMI-SDS were 32.8 kg/m2 and 3.1, respectively. There was a decrease in mean BMI-SDS within each treatment group in all periods, except at 24 months for lifestyle intervention. However, the change in BMI-SDS was not significantly superior in the metformin group when compared to lifestyle intervention. Metformin had greater effectiveness over lifestyle intervention alone in reducing fasting insulin levels and homeostasis model assessment for insulin-resistance index (HOMA-IR) at both 12 and 24 months. Five patients had gastrointestinal adverse effects (12.8%), four requiring dose reduction, but metformin could be resumed in all. Conclusion: Metformin for nondiabetic obese/overweight children and adolescents resulted in a noteworthy insulin resistance improvement, without significant BMI advantage when compared to lifestyle intervention. Metformin metabolic and anthropometric effects appear to be beneficial up to 24 months, without relevant adverse effects, highlighting its potential long-term benefits.
Published: 2015

45. [P006] DRL’s in mammography: Results from 3 dose audits

Author: Idílio Filipe Gomes, Ana Roda, Maria do Carmo Lopes, Inês Santos, and Ana Maria Lopes
Subjects: medicine.diagnostic_test, Bilateral mammography, business.industry, Biophysics, General Physics and Astronomy, General Medicine, Effective dose (radiation), Full field digital mammography, Quartile, Absorbed dose, medicine, Mammography, Radiology, Nuclear Medicine and imaging, business, Nuclear medicine, Quality assurance, Medio lateral oblique
Abstract: Purpose We compare the results of 3 dose audits (2013, 2015 and 2017) for bilateral mammography screening exams performed in a full field digital mammography unit GE Senographe DS. We estimated the average entrance surface dose (ESD) for a sample of at least 50 standard breasts. The results were compared with the European DRL - ESD of the 3rd quartile of the dose survey. We estimated average absorbed dose to the glandular tissue within breast (AGD) for a wide range of breast thicknesses, and converted it into effective dose. Data was presented to the staff to induce a process of optimization as team effort. Methods For each dose audit we selected a sample of more than 150 bilateral mammography screening exams. The percentage glandularity was determined using the qualitative method described by Byng (1994) and compared with Dance (2000) empirical formula. AGD was determined from measurements of the output and exposure data using appropriate conversion factors from IAEA (2007), Dance (2000), Dance (2009). Effective doses were determined using ICRP 103 breast tissue weighting factor 0.12. Results Results (2013): ESD = 5.8 mGy for cranio caudal (CC) and ESD = 6.1 mGy for medio lateral oblique (MLO) projections. These results are considerably below the European DRL’s (10 mGy). E ranged from: E = 0.28 mSv for small breasts (34.5 ± 4.5 mm) to E = 0.69 mSv for very large breasts (84.5 ± 4.5 mm) with larger compressed breast thickness associated with a higher AGD (E); Results (2015): around 30% increase in DRLs: ESD = 8.6 mGy CC and ESD = 8.7 mGy MLO; E ranged from E = 0.38 mSv for small breasts (34.5 ± 4.5 mm) to E = 0.75 mSv for very large breasts (84.5 ± 4.5 mm); Results (2017): within 5% of 2013. Conclusions The 30% increase in the dose results in 2015 resulted from the increased use of Contrast Enhanced Automatic Optimization of Parameters (AOP CNR) mode. This action was investigated and corrected. Dose audits are important part of a quality assurance program.
Published: 2018

46. Autoavaliação de médicos sobre sua formação em Medicina do Adolescente

Author: Elisabete Santos, Ana Manuela Rocha, Alzira Ferrão, Joana Campos, Joana Verdelho Andrade, and Maria Inês Santos
Subjects: medicine.medical_specialty, business.industry, education, Specialty, General Medicine, Test (assessment), Adolescent medicine, Interquartile range, Statistical significance, Family medicine, medicine, Substance use, business, Depression (differential diagnoses), Adolescent health
Abstract: AIMS: To characterize the way in which general and family physicians and pediatricians consider approaching adolescents, identify their qualifications in Adolescent Medicine, ascertain which topics of this specialty these physicians would like to see addressed in future training, and to compare the perceptions of physicians of both specialties with respect to their experience in adolescent health practice.METHODS: Cross-sectional study based on a survey sent by e-mail to 241 physicians in the area of influence of a level II hospital, including specific training interns or experts in Pediatrics and General and Family Medicine from health centers of the municipality of Viseu, Portugal. Chi-square tests or Fisher's exact test were used to test associations between variables, assuming statistical significance when p
Published: 2018

47. Childhood obesity, thyroid function, and insulin resistance – is there a link? A longitudinal study

Author: Maria Inês Santos, Frederico Rosário, Lurdes Lopes, Catarina Limbert, and Filipa Carlota Marques
Subjects: Adult, Male, endocrine system, medicine.medical_specialty, endocrine system diseases, Adolescent, Endocrinology, Diabetes and Metabolism, Thyroid Gland, Thyroid Function Tests, Thyroid function tests, Childhood obesity, Young Adult, Endocrinology, Insulin resistance, HDE END PED, Thyroid-stimulating hormone, Weight loss, Internal medicine, medicine, Humans, Longitudinal Studies, Obesity, Child, Retrospective Studies, medicine.diagnostic_test, business.industry, medicine.disease, Child, Preschool, Pediatrics, Perinatology and Child Health, Female, medicine.symptom, Thyroid function, Insulin Resistance, business, Weight gain, hormones, hormone substitutes, and hormone antagonists
Abstract: Serum thyroid stimulating hormone (TSH) levels are frequently elevated in obese children and are most likely to be associated with insulin resistance. However, clinical relevance of this association remains unclear.To assess the prevalence of hyperthyrotropinemia; to analyze the relationship between TSH and homeostasis model assessment – insulin resistance (HOMA-IR); and to verify whether TSH levels and HOMA-IR vary with weight loss in obese children.Retrospective longitudinal study with data from baseline and 1 year after lifestyle intervention in a pediatric obese group (344 children were recruited and 100 among them completed follow-up). For postintervention analysis, three groups were considered according to body mass index-standard deviation score (BMI-SDS) variations: ≤–0.5 (significant weight loss); 0.5–0 (weight loss); and >0 (weight gain). Statistical analysis was performed using SPSS 19.0The prevalence of increased TSH levels was 9.3%. At baseline TSH (p=0.007), fT4 (p=0.006), and HOMA-IR (pThe prevalence of hyperthyrotropinemia was lower than previously reported. However, cutoff values were adjusted to pubertal stage, suggesting an over report in other studies. Insulin resistance and TSH were positively correlated, independent of body status. Although weight loss was not associated with TSH variation, a decrease in TSH levels was independently associated with decreases in HOMA-IR.
Published: 2015

48. Coutinho et al. Less Is More: Substrate Reduction Therapy for Lysosomal Storage Disorders. Int. J. Mol. Sci. 2016, 17, 1065

Author: Maria Francisca Coutinho, Sandra Alves, and Juliana Inês Santos
Subjects: Sanfilippo Syndrome, 0301 basic medicine, CYP2D6, 1-Deoxynojirimycin, Eligluistat Tartrate, Mucopolysaccharidosis, 030232 urology & nephrology, Pharmacology, Placebo, Catalysis, lcsh:Chemistry, Inorganic Chemistry, 03 medical and health sciences, 0302 clinical medicine, Miglustat, medicine, Humans, Enzyme Replacement Therapy, Substrate reduction therapy, Physical and Theoretical Chemistry, Niemann-Pick type C, lcsh:QH301-705.5, Molecular Biology, Spectroscopy, Sanfilippo syndrome, Gaucher Disease, business.industry, Organic Chemistry, Mucopolysaccharidosis Type III (MPS III, substrate reduction therapy (SRT), Correction, Niemann-Pick Disease, Type C, General Medicine, Mucopolysaccharidoses, medicine.disease, Genistein, Doenças Genéticas, Computer Science Applications, Lysosomal Storage Diseases, Regimen, n/a, 030104 developmental biology, lcsh:Biology (General), lcsh:QD1-999, Combination Ttherapy, business, Eliglustat, medicine.drug
Abstract: The authors wish to make a change to their published paper [1] and add novel references.[eliglustat tartrate] is 100 mg, three times a day”. Nevertheless, this dose regimen refers to miglustat,the other SRT drug currently approved for type 1 Gaucher disease. The management recommendationsare different for eliglustat. Eliglustat is a CYP2D6 and CYP3A substrate. Thus, its co-administrationwith drugs that inhibit CYP2D6 and CYP3A may signiﬁcantly increase the exposure to eliglustat andresult in prolongation of the PR, QTc, and/or QRS cardiac interval, which could result in cardiacarrhythmias [2]. In brief, the recommended dose of 84 mg eliglustat twice daily for extensive andintermediate metabolisers is reduced to 84 mg once daily in poor metabolisers. Still, it is important tonotice that, because of its genetically determined metabolism in the liver, eliglustat requires individualadaptation of the dose and careful supervision of concomitant medications [3].On page 10, the authors refer to an in vivo study using MPS II mice, where a 10-week genisteintreatment resulted in decreased GAG deposits in brain. An important reference, however, has beeninadvertently omitted in the appended review. In 2009, Malinowska and co-workers [4] demonstrateddecreased lysosomal storage in peripheral tissues of a mouse model of Sanﬁlippo syndrome B(Mucopolysaccharidosis IIIB) treated with genistein. Soon after this ﬁrst study, the same team providedproof of concept for that isoﬂavone working as an SRT in the brain of the same mouse model bydemonstrating improved synaptic vesicle protein expression and secondary storage in the cerebralcortex [5]. Considering those results, a phase III double blinded, randomised, placebo controlledclinical trial of high dose oral genistein aglycone in patients with Sanﬁlippo syndrome was designed,and is currently ongoing in Manchester [6]. Even though its outcomes have not been published to date,it has been widely reported in the ﬁeld and at MPS meetings.The authors apologize for any inconvenience. The manuscript will be updated, and the originalwill remain online at the article webpage.
Published: 2017

49. Higher circulating expression levels of miR-221 associated with poor overall survival in renal cell carcinoma patients

Author: Mónica Gomes, Francisca Dias, Rui Medeiros, Juliana Inês Santos, Francisco Pereira Lobo, Joaquina Maurício, Joana Silva, Ana Teixeira, and Marta Susana Ferreira
Subjects: Oncology, Adult, Male, medicine.medical_specialty, Pathology, Disease, Metastasis, Renal cell carcinoma, Internal medicine, microRNA, Medicine, Humans, Stage (cooking), Carcinoma, Renal Cell, Aged, Neoplasm Staging, Proportional Hazards Models, Proportional hazards model, business.industry, Hazard ratio, Cancer, General Medicine, Middle Aged, medicine.disease, Prognosis, Kidney Neoplasms, MicroRNAs, Female, business
Abstract: The mechanisms involved in renal cell carcinoma (RCC) development and progression remain unclear, and new biomarkers for early detection, follow-up of the disease and prognosis are needed in routine practice to improve the diagnostic and/or prognostic accuracy. There is increasing evidence that microRNAs (miRNAs) are involved in cancer development and progression. The up-regulation of miR-221/222 has been described in several human cancers, and during RCC development, this up-regulation can modulate the metastatic process. Our purpose was to investigate the circulating expression levels of miR-221/222 as potential biomarkers for RCC detection and their influence in patients' overall survival. The circulating miR-221/222 was studied by relative quantification in 77 plasma samples. A follow-up study was undertaken to evaluate the overall survival. We observed that RCC patients presented higher circulating expression levels of miR-221 and miR-222 than healthy individuals (2(-ΔΔCt) = 2.8, P = 0.028; 2(-ΔΔCt) = 2.2, P = 0.044, respectively). The RCC patients with metastasis at diagnosis also presented higher circulating expression levels of miR-221 than patients with no metastasis (2(-ΔΔCt) = 10.9, P = 0.001). We also observed a significantly lower overall survival in patients with higher expression levels of miR-221 (48 vs 116 months, respectively; P = 0.024). Furthermore, multivariate Cox regression analysis using the tumour, nodes and metastasis stage (TNM stage); Fuhrman nuclear grade and age (≥60 years) as covariants demonstrated a higher risk of specific death by cancer in patients who presented higher expression levels of miR-221 (hazard ratio (HR) = 10.7, 95% confidence interval 1.33-85.65, P = 0.026). The concordance (c) index showed that the definition of profiles that contain information regarding tumour characteristics associated with circulating miR-221 expression information presents an increased capacity to predict the risk of death by RCC (c index model 1, 0.800 vs model 2, 0.961). Our results, which identified the plasma miR-221/222 at variable levels during RCC development, suggest that these miRNAs may have a potential as noninvasive biomarkers of RCC development.
Published: 2013

50. Obesity and thyroid function in children: cross-sectional study

Author: Rosa Pina, Catarina Limbert, Laura Oliveira, Frederico Rosário, Lurdes Lopes, Maria Inês Santos, and Daniela Amaral
Subjects: Pediatrics, medicine.medical_specialty, Cross-sectional study, business.industry, Medicine, Thyroid function, business, medicine.disease, Obesity
Published: 2013

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