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The purpose of this meta-analysis is to evaluate the association of Epstein-Barr virus (EBV) with oral squamous cell carcinoma (OSCC). We searched the electronic scientific databases of PubMed and Scopus and included a total of 53 studies that were published from 1990 to 2019. The analysis yielded a 45.37% (95% confidence interval [CI]: 38.90-51.84; p < 0.001) overall pooled prevalence of EBV. Studies that used the applied methods of in situ hybridization, polymerase chain reaction, immunology, or RNA microarray showed the following pooled prevalence: 46.08%, 40.32, 54.97%, and 74.89%, respectively. EBV-infected individuals have a 2.5 higher risk for developing OSCC (odds ratio: 2.57; 95% CI: 1.23% to 5.36%; p < 0.001). The present meta-analysis supports the hypothesis of EBV association with OSCC, pointing to this virus as a risk factor for neoplasia. Our findings also suggest that EBV latent transcripts (latent membrane protein 1, EBV nuclear antigen 1 and 2, and EBV-encoded small RNAs) have an important role in this process. Furthermore, novel advancements could arise from large and standardized studies that are constructed to probe for other latent gene expression, eliminate confounding factors (tobacco, alcohol, and high-risk human papillomavirus infection), and define the relationship between EBV and oral carcinomas.

Objective: to investigate the perceptions of nursing professors from an undergraduate course of the domains of the CoreCompetencies Framework for Health Promotion and find out how these domains are applied in their teaching practice. Method: The studywas conducted in 2017 at a public institution of higher education in the Northeastern Region of Brazil. Sixty-two (62) teachers who met theestablished inclusion and exclusion criteria were invited. Of these, 15 participated in the study. Results: The following categories emerged:“Nursing educators’ knowledge about health promotion: recognizing the domains” and “Nurse Educators’’ Practices in Health Promotion:Application of the domains of the Core Competencies Framework for Health Promotion.” Conclusion: Training and continuing educationstrategies on the referred subject should be provided. Objetivo: verificar las perspectivas de docentes de un curso de graduación en enfermería acerca de los dominios del CoreCompetencies Framework for Health Promotion, y como esos dominios se encuentran en su práctica. Método: el estudio ocurrió en el añode 2017, en una institución pública de enseñanza superior de la Región Nordeste. Se invitaron 62 docentes que obedecían a los criteriosde inclusión y exclusión establecidos, de los cuales 15 participaron de la investigación. Se analizaron los resultados por medio del análisisde contenido. Resultados: las categorías resultantes fueron: “Saberes de los docentes acerca de la promoción de la salud: reconociendolos dominios” y “Prácticas de los docentes en promoción de la salud: aplicabilidad de los dominios del Core Competencies Frameworkfor Health Promotion”. Hubo divergencias acerca de los saberes y prácticas que pueden influenciar la formación de los enfermeros sobrelas competencias necesarias a la promoción de la salud. Conclusión: es importante promover estrategias de cualificación y formacióncontinuada al rededor de la temática en cuestión. Objetivo: verificar as perspectivas de docentes de um curso de graduação em enfermagem acerca dos domínios do Core Competencies Framework for Health Promotion, e como estes estão presentes em sua prática. Método: o estudo foi realizado no ano de 2017, em uma instituição pública de ensino superior da Região Nordeste. Foram convidados 62 docentes que atenderam aos critérios de inclusão e exclusão estabelecidos, dos quais 15 participaram da pesquisa. Os resultados foram analisados a partir da análise de conteúdo. Resultados: emergiram as categorias: “Saberes dos docentes acerca da promoção da saúde: reconhecendo os domínios” e “Práticas dos docentes em promoção da saúde: aplicabilidade dos domínios do Core Competencies Framework for Health Promotion”. Divergências encontradas a respeito dos saberes e práticas podem influenciar a formação dos enfermeiros em relação às competências necessárias à promoção da saúde. Conclusão: é importante oportunizar estratégias de qualificação e formação continuada em tornoda temática em questão.

Objectives Human papillomavirus (HPV) has been implicated as a major factor in cervical carcinogenesis. However, many pieces of evidence gathered over the last two decades suggest Epstein-Barr virus (EBV) plays a secondary role in this process. The purpose of the present meta-analysis was to determine whether the presence of EBV infection increases the risk of cervical carcinoma. Methods Based on 25 articles, the analysis yielded a 33.44% overall pooled prevalence of EBV. Results The pooled prevalence was higher in patients with carcinoma (43.63%) than in healthy patients (19.0%) or patients with cervical intraepithelial neoplasia 1 (CIN1) (27.34%) or CIN2/3 (34.67%). Co-infection with EBV and HPV displayed a similar pattern. EBV infection was significantly and positively associated with lesion grade in cervical epithelia and was more prevalent in malignant lesions. Moreover, cervical carcinoma occurred four times as often among EBV positive women as in women without EBV infection (OR = 4.01 [1.87–8.58]; p Conclusions The existence of EBV(+)HPV(−) carcinomas, the confirmed expression of latent oncoproteins (EBNA1, EBNA2, LMP1) and EBERs in tumor cells, and the association of EBV with the integration of high-risk-HPV DNA in malignant specimens point to EBV as a co-factor (so far underestimated) in the genesis and/or progression of cervical carcinoma. However, further studies are necessary before the link between EBV and cervical carcinoma can be established.

This study aimed to describe the socio-demographic and clinical profile of elderly with diabetes mellitus in a Primary Health Care Unit. This is a descriptive and transversal study conducted in a city of Ceara State. The sample consisted of 55 elderly patients with type 2 diabetes mellitus. Data were collected from July to August 2014 through a socio-demographic and clinical variables form. The descriptive statistics was used for the analysis. The mean age of 71 years old was observed; 67.3% of the sample were women; 58.2% married; 30.9% illiterate; 83.6% with income less than two minimum wages; 61.8% were sedentary; 54.5% were overweight; 53.4% of grade I obesity; and 69.1% with altered postprandial glucose. The mean duration of the disease was more than 10 years, and diabetic complications were found. The elderly’s profile can contribute to more health risks and serious impairment of quality of life