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Revive capsule, also called Kedi Revive capsule is a polyherbal formulation manufactured by Kedi healthcare company limited in Hong Kong, China. The drug is widely used around the globe, especially in Africa and Asia for the treatment of erectile dysfunction or enhancement of libido in men. Each capsule contains 400 mg of the constituent herbs including 80 mg of herb Epimedii, 80mg of Radix ginseng, 40 mg of Cordyceps militaris, 80mg of Tribulus terrestris, 80mg of Radix polygoni multiflori, and 40 mg of Eucommia ulmoides, with its effects exerted four hours after administration via the oral route. The adult man dosage is two capsules (800 mg) to be taken once daily for at least 28 days (before significant improvements may be observed when used to treat erectile dysfunction). Phytochemical analysis of the drug reported the presence of flavonoids, cardiac glycosides, tannins, polyphenols, alkaloids and quinones. Due to its speculated use in the treatment of erectile dysfunction or enhancement of libido, it may be referred to as an herbal phosphodiesterase type-5 inhibitor, that acts by selectively inhibiting the enzyme phosphodiesterase type-5, and thus enhancing increased arterial blood flow into the penis, which results in penile erection; however, the mechanism of action of this drug may be attributed to the contained phytochemicals. Additionally, due to its increased use, it is highly recommended that further studies be conducted on this drug to ascertain its effects on some biochemical components and vital organs of the body.

This study adopted a correlational investigation to examine the relationship between Cost Management and Supply Chain Performance of food and Beverages firms in Port Harcourt. The population for this study consists of seventeen (17) food and beverages firms in Port Harcourt. The researcher conducted a census study due to the small size of the population. However, a total of Eighty Five (85) top managerial staff of the firms constituted the respondents for the study. Furthermore, Eighty five (85) copies of the questionnaire were administered to the top managers of each of the 17 food and beverages companies while seventy (70) copies were retrieved and used for the study. The respondent’s demographics were analyzed by employing the measures of central tendencies and measures of dispersions. Correspondingly, the Pearson Product Moment Correlation was used in testing the study hypotheses in other to ascertain the relationship between the predictor variable (Cost Management) and the criterion variable (Supply Chain Performance).The result of the analysis revealed that Cost Management significantly influenced Supply Chain Performance of food and Beverages firms in Port Harcourt. Hence, the authors concluded that Cost Management significantly affect Supply Chain Performance and therefore recommended that the management of food and Beverages firms in Port Harcourt should adopt appropriate cost management strategies in other to increase their level of supply chain performance.

Water is a basic and necessary requirement for the existence of animals and plants, yet it is limited in supply in several parts of the world. Surges in human population and demand for water for different purposes such as agricultural, domestic and industrial usages are the major factors leading to water scarcity. Nigeria and the study area are blessed with abundant water resources including surface and groundwater, yet there is a palpable lack of adequate and safe potable water. Consequently, the populace resorts to private sources of water supply which has its negative externalities even though the effort seems laudable. Based on the above, the study examined the proliferation of private water supply, its challenges and socio-economic implications in Obio /Akpor local government area. The study adopted a cross-sectional survey, and data were collected with the use of both closed and open-ended questionnaire. It also involved the collection of the private borehole points with the use of a handheld global positioning system (GPS). Data were analyzed using the descriptive method of analysis and data presented in charts and tables. The result of the study showed that there were no specific distances maintained between borehole points, a good number of borehole locations were clustered in some parts of the study area. Also, distances between soakaway pits and borehole points were inadequate in some communities. Based on the prevalent minimum wage in the study area, both households that operate boreholes and those that buy water spent more. Some of the socio-economic implications of private provision of water supply include too much spending on water, creation of livelihoods for water vendors and vulnerability to waterborne disease such as typhoid since there is no minimum standard for borehole drilling and distance in the study area. The study recommended that the government should develop a private borehole drilling standard that would include the minimum distance that must be maintained between two boreholes on vertical and horizontal lines. Also, the activities of the private water vendors should be regulated, and operating license obtained before operating commercial boreholes. The study concluded thus, there should be a synergy between the private and public sector to ensure safe and affordable water supply since their activities cannot be undermined.

Building resilience capacities to survive flood disasters in vulnerable communities in the global south encompasses techniques that are unique to such communities. These strands of unique techniques are embedded in their indigenous knowledge as a people and revealed through the actions they display during such times of disaster. Data was obtained from four communities in the Orashi region in the aftermath of the 2012 floods in Nigeria, to investigate the techniques and actions adopted to help build local resilience capacity amongst vulnerable communities there. Interviews and focus groups were the primary means of data collection and analysis was done qualitatively. The findings revealed five key attributes the communities possessed that enabled them build their resilience capacity to cope with the flood disaster.

Consumption of foods, water, vegetables, fruits, undercooked/ground/raw meat, unpasteurized milk or milk products contaminated with the bacterium strain Escherichia coli 0157:H7 has become a serious public health concern. This strain naturally inhabits the digestive tract of healthy cattle, and is released into the environment through the faeces of the animal. This strain cause haemorrhagic enterocolitis or gastroenteritis, and then haemolytic uraemic syndrome (HUS). HUS is a disorder characterised by haemolytic anaemia, low platelet count and acute kidney failure, and this disorder is a consequence of the production and action of Shiga-like toxin produced mainly by this bacterial strain (accounting for 90 percent of all cases), and occurs mainly in children less than five (5) years of age, but also occurs in the elderly. After infection with this bacterial strain, the disorder begins with intestinal perforation and ulceration leading to bloody diarrhoea, and consequently acute kidney injury, thrombocytopenia and microangiopathic haemolytic anaemia. In conjunction with clinical manifestations, several laboratory investigations (haematological, biochemical and microbiological assays) are implicated in the diagnosis of HUS. There is currently no specific treatment for HUS; however, supportive care (such as treatment of hypertension, fluid and electrolyte imbalance, haemodialysis, blood transfusion, etc) happens to be the only ameliorative measure for this disorder.

Heavy metals gain entry into biological systems mainly via inhalation and ingestion, and also via radiation or radio-therapeutic measures. The accumulation of these heavy metals in biological systems overtime may cause several deleterious health challenges such as liver, kidney and brain damages amongst others. Intoxication with heavy metals may either be acute or chronic, and because the kidney has the ability to reabsorb and accumulate divalent metals, it happens to be the primary target organ for heavy metal toxicity, inducing renal damage. The extent of this damage depends on the dose, nature, route and duration of exposure to the metal. Chronic kidney disease (CKD) is characterized by a permanent loss of nephrons accompanied by an eventual decline in glomerular filtration rate (GFR); this (to a greater extent) maybe due to heavy metal intoxication and the renal reabsorption of these heavy metals. Although 70 percent of the heavy metals are reabsorbed in the proximal tubule, all segments of the nephrons are involved in the reabsorption of these metals, where several transporters such as the Divalent Metal Transporter (DMT)-1, Na+/amino acid co-transporter, Zinc Transporter (ZnT)-1 and stretch-activated cation channels (SAC) facilitate the reabsorption. In the nephrons of each kidney, heavy metals are primarily reabsorbed via the apical membrane and accumulate at the basolateral membrane; these heavy metals do not readily exit the basolateral membrane, which overtime may result in chronic inflammation of the nephrons, fibrosis and kidney failure. However, the loss of nephrons and decline in GFR in CKD are compensated by certain changes (glomerular and cellular, enhanced renal blood flow, enhanced single nephron glomerular filtration rate and tubular hypertrophy) in the remaining functional nephrons. These changes help to deliver solutes to the remaining functional nephrons for uptake by the epithelial cells of the renal tubules. Also, because the luminal and basolateral surfaces of tubular epithelial cells of the remaining healthy nephrons are also potentially exposed to higher levels of metabolic wastes, xenobiotics, heavy metals and other nephrotoxicants, renal injury, tubular or glomerulosclerosis, and death of these nephrons occur. These compensatory changes become insufficient once about 75 percent of the nephrons are no longer functional and incapable of maintaining homeostasis and renal function. This results in the accumulation of metabolic wastes in the blood, and induction of metabolic disturbances and/or organ intoxication.

In this study, the concentrations of urea were assayed in both blood and saliva of 130 haemodialysis patients; before haemodialyis(pre-haemodialysis) and after haemodialysis (post haemodialysis); and 60 healthy individuals who made up the control group. The method used for urea assay was urease method. The mean±SD concentrations of salivary urea in pre and post haemodialysis patients, as well as control group, were 17±0.6 mmol/l, 9.1±0.5 mmol/l and 4.0±0.3 mmol/l respectively. The mean±SD concentrations of blood urea in pre and post haemodialysis patients, as well as control group, were 21.6±0.5 mmol/l, 9.1±0.4 mmol/l and 4.2±0.2 mmol/l respectively. The correlation coefficient between blood and salivary urea in pre-haemodialysis patients is 78.8% while that for post haemodialysis patients is 60.6% and for the control group is 90%. The ANOVA results of salivary urea in the three groups (pre, post and control) showed a significant difference with P-value ˂0.05. The ANOVA results of blood urea in the three groups (pre, post and control) showed a significant difference with P-value ˂0.05. From the various results obtained, saliva can serve as a diagnostic biofluid for renal disease especially with the salivary urea as the biomarker. Also, the salivary renal biomarker (urea) responds to changes in concentrations after therapeutic consideration. This study is in consonance with other literature that saliva is a diagnostic fluid for kidney disease; however, there is a need to carry out more research works to continually unveil the diagnostic potential of saliva in kidney disease.

History of upper respiratory tract infection in the mother or siblings was associated with higher risk of acute lower respiratory tract infection in cases. Most upper respiratory tract infections were caused by viral pathogens and likely to occur in many members of the family. The study aimed to determine the existence and pattern of relationship between risk of acute respiratory infection (ARI) among infants and exposure to pre-existing maternal/caregiver acute respiratory tract infection. The study was designed as a community-based Nested case-control study of 1100 infants randomly selected from 12 communities out of 6 Local Government Areas of the 3 senatorial districts of Rivers State. A multistage random sampling technique was used in selecting the subjects up to the community level. Descriptive method was used to represent the characteristics of the subjects and the differences in ARI between exposed and unexposed infants were tested in a bivariate logistics regression at 5% level of significance. Odds ratio (OR) was used to interpret the size effect measures of ARI on exposure to pre-existing maternal/caregiver ARI differences. A total of 275 Cases of ARI and 825 controls were included in the study. Among exposed infants (N = 104), ARI cases were found to be higher n = 80 (76.9%) than in control n = 24 (23.1%). Whereas, among unexposed infants N = 991, ARI cases were found to be lower n = 195 (19.7%) than in control n = 796 (80.3%). For the exposed infants, the odds for ARI were 13.5 times significantly higher compared to those of their unexposed counterparts (OR-Unadjusted = 13.52, (p < 0.0001, 95% CI = 0.047 - 0.121)). The findings will widen the horizon in the etiological consideration of ARI among infants vis-a-vis exposure potential to pre-existing maternal/caregiver ARI via nursing care. Therefore, community-based sensitization programme on barrier nursing care techniques and personal hygiene practices should be on focus.

Background: Revive capsule is a polyherbal formulation commonly used to treat erectile dysfunction or enhance libido in men. Some of the individual herbs used in the formulation of this drug have been known scientifically to affect various biochemical components of the human body; hence this study was aimed at evaluating the reproductive profile in male albino rats following varied duration of administration with Revive capsule. Methods: A total of 42 male albino rats were used for the study, and were divided into six (6) groups of seven (7) rats each. They were allowed to acclimatize for two (2) weeks by maintaining 12-hour light and dark cycles daily, with access to standard feed and water ad libitum. Group A (negative control) rats were administered with distilled water once daily, while groups B, C, D, E and F were administered once daily with 72 mg/kg of Revive capsule for 1 week, 2 weeks, 3 weeks, 4 weeks and 6 weeks respectively. The rat dose administered was extrapolated from the human dose using the formula by Paget and Barnes. At the end of each treatment week, the rats were allowed to fast overnight, followed by their anaesthetization using chloroform, and blood sample collection via jugular vein puncture. Also, the testes were excised; the epididymis were also excised from the testes and used immediately for semen analysis, while the epididymis-free testes were examined histologically. Rat-specific test kits with ELISA method were used to analyze serum LH, FSH and testosterone.Results: The results showed a significant increase (p

Rivers generally have been source of livelihood for several persons in both developed and developing countries, and the rivers have been exploited without recourse to the consequences of this action by those involved. The aim of this research is to assess the social and economic consequences of sand mining on communities along the Victory River. The objectives are to: examine residents’ perception, identify the impacts of sand mining in their domain and propose mitigation measures for moderate and major negative impacts and enhancement measures for positive impacts of sand mining. Hazards and effects management process (HEMP) was used identify the impacts of sand mining on the communities and propose mitigation measures for moderate and major negative impacts and enhancement measures for positive ones. The study adopted multistage sampling technique by identifying all the communities along the Victory River and purposively four (4) communities were selected for the study. Mixed methods were used to collect data with one-hundred and twenty-three (123) structured questionnaires and key informant interviews. The study found that continuous river sand mining had altered the river courses and increased the width and depth of the Victory River. Livelihood chain of the people have been distorted leading to diminished purchasing power, increased poverty level and other associated social vices. There were also identified socio-economic benefits like employment and revenue generation for the communities. The study recommends that: river channel cross sections should be benchmarked using aerial photographs and periodic hydrographic survey, effective social management plan and enhancement measures be taken, enforcement of relevant laws to control the activities of sand miners and their host communities alike.

This is a review paper that brings to focus, concepts of Community Health Practice that connect Community Health Practitioners’ Roles to National development in view of its composite index improvement measure of social welfare services provision among others for the citizens of a country over time, with particular emphasis on medical care component of such index aimed at reduction in diseases and poverty in the population. The objective of the review work is to determine the extent to which Community Health Practice, particularly by Community Health Practitioners is capable of ensuring National Development in democratic governance or otherwise, in the context of our country, Nigeria. The methodology applied was traditional review of published literatures concerning the subject and findings of operational research of programme implemented by Community Health Practitioners at the Primary Health Care facilities and household level in the communities. This paper emphasizes on Primary Health Care services delivery contribution to National Development, since it is the level where Community Health Practitioners are mainly commissioned to render their services. Home-Based Care Strategy for Integrated Maternal, Newborn and Child Health piloted in three (3) local government areas (Ahoada West, Etche and Oyigbo) in Rivers State, Nigeria, in 2012 and implemented by Community Health Practitioners, aimed at reducing maternal, newborn and child morbidity and mortality by 20% by 2015 in line with the United Nations (UN) Millennium Development Goals 4 and 5, had been shown to achieve an average of 26% improvement in utilization of maternal and newborn health services, an average of 27% overall reduction in maternal malnutrition status, an average of 14% overall improvement in under 5 years malnutrition status among others in 2013 on comparing with baseline indicators. Nigeria also attained 80% coverage in routine immunization in most vaccine preventable diseases except Tetanus Toxiod (TT) 2 (54%) in 2013 to achieve herd immunity of the community to prevent transmission of disease pathogen to cause a disease. Community Health Practitioners are the frontline Primary Health Care Professionals charged with the responsibility of implementation of immunization programmes in Nigeria and therefore contributing significantly to the prevention and control of targeted vaccine preventable diseases in Nigeria Health System. Our findings on factors militating against Community Health Practitioners’ Roles in National Development as elicited in this paper may form basis for empirical studies to determine the level of significance of each of these factors. In conclusion, it is when the Community Health parameters are adequately addressed that we can ensure sustainable National Development and we can say we have succeeded in our various strategic agenda of government at whatever level that makes up the complex whole. This brings to fore, the importance of the roles of Community Health Practitioners in health care delivery to National Development in the context of our country, Nigeria.

Background and Aim: Fish plays a crucial role in human nutrition and food supply across the globe, particularly among the poor segment of the society. Food fish currently represents the major source of animal protein needed for growth and development, especially among the children and women who are more vulnerable to malnutrition in developing countries. The importance of food to an individual and society cannot be over emphasized, as food is a basic necessity of life and sufficient intake of quality food is imperative for people to live a strong, vibrant and productive life. Considering the importance of fish food, this study therefore assessed the contribution of brackish water fish farming to stable fish supply and food security in coastal communities of Rivers State.

Statement of the problem: Gender had a much wider influence on disease than is usually acknowledged. More so, relative contributions of social and biological factors had not been clearly delineated for many diseases. Higher mortality rates are usually observed in male infants with lower acute respiratory infections (ARIs) and pneumonia particularly during the first month of life than the female infants due to immature lungs in males. The rate declines between 6 and 12 months after birth. The study aims to determine the existence and pattern of relationship between risk of ARI and gender. Methodology and theoretical orientation: The study was designed as a community based retrospective casecontrol study of 1,100 infants randomly selected from 12 communities out of 6 Local Government Areas of the 3 senatorial districts of Rivers State. A multistage random sampling technique was used in selecting the subjects up to the community level. Descriptive method was used to represent the characteristics of the subjects and the differences in ARI between male and female infants were tested in a bivariate logistics regression at 5% level of significance. Odds ratio (OR) were used to interpret the size effect measures of ARI on gender differences. Findings: A total of 275 Cases of ARI and 825 controls were included in the study. The ARI cases were found to be slightly higher in Female infants (27.8%) than in the Male infants (22.4%). For the Female infants, the odds for ARI were 1.3 times significantly higher compared to those of their Male counterparts (OR=1.32, p=0.048, 95% CI=1.003-1.735). Conclusion and significance: Understanding such differences between Male and Female infants will enhance the knowledge about the epidemiology, outcome and effectiveness in prevention and control of ARIs. Recommendation: Awareness creation on gender differences in susceptibility to acute-respiratory infection among infants requires sustainable attention.

This research investigated whether or not auditing is useful to the strategy evaluation and control process in Nigerian business organizations. In sourcing for data, we used structured questionnaire as well as personal interviews. The data collected were analyzed using the simple percentage and frequency distribution. We found that effective internal audit helps in the strategy evaluation and control process in the organizations we studied. Our conclusion is that, the effective performance of internal audit is crucial for management to be able to evaluate and control strategy in modern organization. SOPHIA: An African Journal of Philosophy Vol. 8 (2) 2006: pp. 109-117

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An Amazonian savanna in northern Brazil known as the Cerrado of Amapá is under imminent threat from poor land-use planning, the expansion of large-scale agriculture and other anthropogenic pressures. These savannas house a rich and unique flora and fauna, including endemic plants and animals. However, the area remains under-sampled for most taxa, and better sampling may uncover new species. We estimate that only ~9.16% of these habitats have any kind of protection, and legislative changes threaten to further weaken or remove this protection. Here we present the status of knowledge concerning the biodiversity of the Cerrado of Amapá, its conservation status, and the main threats to the conservation of this Amazonian savanna. To secure the future of these unique and imperilled habitats, we suggest urgent expansion of protected areas, as well as measures that would promote less-damaging land uses to support the local population. Made available in DSpace on 2017-11-17T23:15:15Z (GMT). No. of bitstreams: 1 CPAFAP2017Biodiversitythreatsandconservation.pdf: 2128567 bytes, checksum: 5cb4b5c05db3b0c07fc15084b072beb1 (MD5) Previous issue date: 2017-10-26

Submitted by Guilherme Lemeszenski (guilherme@nead.unesp.br) on 2013-08-22T19:07:01Z No. of bitstreams: 1 S1516-35982006000800001.pdf: 132948 bytes, checksum: 070370847b7ba38ab9083f386a63e62b (MD5) Made available in DSpace on 2013-08-22T19:07:01Z (GMT). No. of bitstreams: 1 S1516-35982006000800001.pdf: 132948 bytes, checksum: 070370847b7ba38ab9083f386a63e62b (MD5) Previous issue date: 2006-12-01 Made available in DSpace on 2013-09-30T20:11:28Z (GMT). No. of bitstreams: 2 S1516-35982006000800001.pdf: 132948 bytes, checksum: 070370847b7ba38ab9083f386a63e62b (MD5) S1516-35982006000800001.pdf.txt: 30325 bytes, checksum: 1881ac169b33174f75c24b968a0dcf4a (MD5) Previous issue date: 2006-12-01 Submitted by Vitor Silverio Rodrigues (vitorsrodrigues@reitoria.unesp.br) on 2014-05-20T13:40:17Z No. of bitstreams: 2 S1516-35982006000800001.pdf: 132948 bytes, checksum: 070370847b7ba38ab9083f386a63e62b (MD5) S1516-35982006000800001.pdf.txt: 30325 bytes, checksum: 1881ac169b33174f75c24b968a0dcf4a (MD5) Made available in DSpace on 2014-05-20T13:40:17Z (GMT). No. of bitstreams: 2 S1516-35982006000800001.pdf: 132948 bytes, checksum: 070370847b7ba38ab9083f386a63e62b (MD5) S1516-35982006000800001.pdf.txt: 30325 bytes, checksum: 1881ac169b33174f75c24b968a0dcf4a (MD5) Previous issue date: 2006-12-01 Objetivou-se determinar a digestibilidade aparente de nutrientes de rações com diferentes níveis de fitase formuladas com alimentos de origem vegetal, em 90 juvenis de tilápia-do-nilo, pesando em média 120,0 g, alojados em nove tanques-rede (dez peixes/tanque). Adotou-se delineamento inteiramente casualizado, com nove tratamentos e seis repetições. Os tratamentos consistiram de uma ração suplementada com fósforo (controle) e de oito sem suplementação de fósforo, porém com 500, 1.000, 1.500, 2.000, 2.500, 3.000, 3.500 e 4.000 unidades de fitase (UF)/kg de ração, todas isoenergéticas e isoprotéicas. A inclusão de 1.500 UF melhorou a digestibilidade da MS e da EB e a disponibilidade de cálcio e fósforo das rações. O nível de 1.000 UF melhorou a disponibilidade de zinco e manganês. The nutrient apparent digestibility of diet with increasing phytase levels based on vegetable ingredients fed to 90 Nile Tilapia juveniles averaging 120.0 g and allotted to none tanks (ten fishes/tank) was determined. The experiment was analyzed as a complete randomized design with nine treatments and six replicates. The treatments consisted of: control (with phosphorus supplementation) and eight treatments without phosphorus supplementation (with 500, 1,000, 1,500, 2,000, 2,500, 3,000, 3,500, and 4,000 units of phytase [UF]/kg of diet). All diets were formulated to be isoenergy and isoprotein. The 1,500 UF treatment increased DM and GE digestibility and dietary Ca and P availability. The 1,000 UF treatment increased Zn and Mn availability. IBAMA CEPTA UNESP FMVZ DMNA UNESP FMVZ DMNA