255 results on '"Hyun-Ju Kim"'
Search Results
2. Pathological Worry is Related to Poor Long-Term Pharmacological Treatment Response in Patients With Panic Disorder
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Hyun-Ju Kim, Sang-Hyuk Lee, and Ji Eun Kim
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Penn State Worry Questionnaire ,medicine.medical_specialty ,Pathological worry ,media_common.quotation_subject ,Treatment response ,behavioral disciplines and activities ,Internal medicine ,mental disorders ,medicine ,Pathological ,Biological Psychiatry ,Depression (differential diagnoses) ,media_common ,Panic disorder ,business.industry ,Beck Depression Inventory ,Panic Disorder Severity Scale ,medicine.disease ,Pharmacotherapy ,Psychiatry and Mental health ,Anxiety sensitivity ,Original Article ,Worry ,business ,Agoraphobia - Abstract
Objective Several predictors of unfavorable pharmacological treatment response (PTR) in panic disorder (PD) patients have been suggested, such as the duration of the illness, presence of agoraphobia, depression, being a woman, and early trauma. This study aimed to examine whether pathological worry is associated with PTR in PD patients.Methods This study included 335 PD patients and 418 healthy controls (HCs). The Penn State Worry Questionnaire (PSWQ), the Early Trauma Inventory Self Report-Short Form (ETISR-SF), Beck Depression Inventory (BDI), Panic Disorder Severity Scale (PDSS), and Anxiety Sensitivity Inventory-Revised (ASI-R) were administered. We measured the PTR at 8 weeks and 6 months. Student t-test, chisquare tests, Pearson’s correlation analyses, and binary logistic regression model were used.Results Our results showed that the total scores of the PSWQ correlated with the ETISR-SF, BDI, and ASI-R were significantly higher in patients with PD compared with HCs. The PSWQ and BDI could predict unfavorable PTR at 6 months in PD patients.Conclusion This is the first study to demonstrate that pathological worry may contribute to poor long-term PTR in PD patients. Therefore, our research suggests that clinicians must be aware of worry to optimize PTR for PD patients.
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- 2021
3. In ovariectomy-induced osteoporotic rat models, BMP-2 substantially reversed an impaired alveolar bone regeneration whereas PDGF-BB failed
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Kyoung-Hwa Kim, In-Chul Rhyu, Yong-Moo Lee, Young Ku, Hyun-Ju Kim, and Yang-Jo Seol
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medicine.medical_specialty ,Bone Regeneration ,Platelet-derived growth factor ,Ovariectomy ,Osteoporosis ,Rat model ,Becaplermin ,Bone Morphogenetic Protein 2 ,Postmenopausal osteoporosis ,Bone morphogenetic protein 2 ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,Transforming Growth Factor beta ,Internal medicine ,medicine ,Animals ,Humans ,General Dentistry ,Dental alveolus ,biology ,business.industry ,Regeneration (biology) ,Proto-Oncogene Proteins c-sis ,030206 dentistry ,medicine.disease ,Recombinant Proteins ,Rats ,Endocrinology ,chemistry ,030220 oncology & carcinogenesis ,biology.protein ,Female ,business ,Platelet-derived growth factor receptor - Abstract
We previously suggested an ovariectomy (OVX)-induced osteoporotic rat model showing an impaired alveolar bone defect healing. This study aimed to evaluate and compare the effects of recombinant human bone morphogenetic protein-2 (rhBMP-2) and recombinant human platelet-derived growth factor-BB (rhPDGF-BB) on alveolar bone defect healing in OVX-induced osteoporotic rats. A total of forty-one female rats were divided into four groups: a collagen group (n=10), a PDGF-BB group (n=11), a BMP-2 group (n=10), and a control group (n=10). Four months after OVX, alveolar bone drill-hole defects were created and grafted with collagen gel, rhPDGF-BB/collagen gel, or rhBMP-2/collagen gel. The defects in the control group were not grafted with any material. Defect healing was evaluated by histological, histomorphometric, and microcomputed tomographic (micro-CT) analyses at 2 and 4 weeks. According to the micro-CT analysis, the BMP-2 group exhibited the greatest bone volume fraction among all groups, while the PDGF-BB group did not show significant differences compared with the collagen group. The histomorphometric analysis showed a significantly larger amount of new bone area in the BMP-2 group than in the control and collagen groups at 4 weeks; however, the PDGF-BB group did not reach significant superiority compared with the other groups. Alveolar bone regeneration was significantly enhanced by the local use of rhBMP-2/collagen gel compared with the use of rhPDGF-BB/collagen gel in OVX-induced osteoporotic rats. A treatment modality using rhBMP-2 may be a promising approach to promote alveolar bone regeneration in patients suffering from postmenopausal osteoporosis.
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- 2021
4. The Effect of Airline Selection Attributes on Domestic Airline Choice: Focused on the Moderating Effect of Travel Involvement
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Hyun-Ju Kim
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Econometrics ,Business ,Selection (genetic algorithm) ,Multinomial logistic regression - Published
- 2021
5. A Study on the Acceptance Pattern of ‘the tunes for Chinese Ci poetry 「Wushan Yiduanyun」’ in Korea: Focusing on the Eight Chapter Style
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Hyun Ju Kim and Youn Ju Baek
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Literature ,History ,Poetry ,business.industry ,General Medicine ,business ,Style (sociolinguistics) - Published
- 2021
6. An Analysis of the Significance on Implementing the Policy in the Land Photovoltaic Power Generation Project
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Yong-O Kim, Yeon, Ik-Jun, Jung, Ju-yong, Cho Kim, Hyun-ju Kim, and Yu-Jeong Kim
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business.industry ,Photovoltaic power generation ,Environmental science ,Environmental economics ,business ,Renewable energy - Published
- 2021
7. A randomized, double-blind, placebo-controlled crossover clinical trial to evaluate the anti-diabetic effects of Allium hookeri extract in the subjects with prediabetes
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Soo-Wan Chae, Su-Jin Jung, Byung-Hyun Park, Jae-Heon Yang, Sung-Hyen Lee, Do-Youn Jeong, Eun-Kyung Choi, You-Suk Kim, Ui-Jin Bae, Soo Hyun Park, and Hyun-Ju Kim
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Blood Glucose ,Male ,0301 basic medicine ,medicine.medical_treatment ,Gastroenterology ,chemistry.chemical_compound ,0302 clinical medicine ,Insulin ,Medicine ,Prediabetes ,Plasma glucose ,Cross-Over Studies ,C-Peptide ,biology ,Incremental area under the curve ,Allium hookeri ,lcsh:Other systems of medicine ,Middle Aged ,Female ,Animal studies ,Research Article ,Adult ,medicine.medical_specialty ,030209 endocrinology & metabolism ,Oral glucose tolerance test ,Placebo ,Allium ,Prediabetic State ,03 medical and health sciences ,Double-Blind Method ,Internal medicine ,Republic of Korea ,Humans ,Aged ,Glycemic ,Glycated Hemoglobin ,030109 nutrition & dietetics ,Triglyceride ,Plant Extracts ,business.industry ,Glucose Tolerance Test ,medicine.disease ,biology.organism_classification ,lcsh:RZ201-999 ,Clinical trial ,Complementary and alternative medicine ,chemistry ,Hemoglobin A1c ,business ,Biomarkers - Abstract
Background Allium hookeri is widely consumed as a vegetable and herbal medicine in Asia. A. hookeri has been reported anti-inflammatory, anti-obesity, osteoblastic, anti-oxidant, and anti-diabetic effects in animal studies. We investigated the anti-diabetic effects of A. hookeri aqueous extract (AHE) in the Korean subjects. Methods Prediabetic subjects (100 ≤ fasting plasma glucose (FPG)
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- 2020
8. Impact of the Environmental Factors on Adolescents’ Food Purchasing Attitudes
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Hyun-Ju Kim and Kim Yoo Kyeong
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Environmental health ,Business ,Food purchasing - Published
- 2020
9. Statins and metachronous recurrence after endoscopic resection of early gastric cancer: a nationwide Korean cohort study
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Hyunsoo Chung, Hyun Chae Jung, Sang Kil Lee, Hyun-Ju Kim, and Sang Gyun Kim
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Male ,Stomach neoplasm ,Cancer Research ,medicine.medical_specialty ,medicine.medical_treatment ,Gastroenterology ,03 medical and health sciences ,0302 clinical medicine ,Gastrectomy ,Stomach Neoplasms ,Surgical oncology ,Internal medicine ,medicine ,Humans ,Retrospective Studies ,business.industry ,Proportional hazards model ,Neoplasms, Second Primary ,General Medicine ,Middle Aged ,Prognosis ,Early Gastric Cancer ,Survival Rate ,Oncology ,Case-Control Studies ,030220 oncology & carcinogenesis ,Propensity score matching ,Female ,030211 gastroenterology & hepatology ,Hydroxymethylglutaryl-CoA Reductase Inhibitors ,Neoplasm Recurrence, Local ,business ,Follow-Up Studies ,Abdominal surgery ,Cohort study - Abstract
Statins have shown to reduce the risk of various cancers. However, their effects on metachronous recurrence (MR) after endoscopic resection (ER) for early gastric cancer (EGC) are unknown. We evaluate their effects on MR development after ER for EGC. We selected 11,568 patients who received ER for EGC from 2002 to 2011 from the Korean National Health Insurance database and classified into 2 groups: control and statins using propensity score matching. Metachronous recurrence was defined as the second ER or gastrectomy performed 6 months after the first ER. Mean follow-up period was 8.8 ± 3.1 years. Statins showed a significantly lower incidence of MR than the control group (12.5% vs 2.2%, respectively, P
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- 2020
10. Palliative Cancer Care Stress and Coping Among Clinical Nurses Who Experience End-of-Life Care
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Hyun Ju Kim and Kisook Kim
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Advanced and Specialized Nursing ,Community and Home Care ,Coping (psychology) ,Palliative care ,business.industry ,Stressor ,Psychological intervention ,Interpersonal communication ,Compassion fatigue ,Medicine ,Job satisfaction ,business ,End-of-life care ,Clinical psychology - Abstract
The increasing number of cancer patients and prolonged periods of illness have led to an increase in nurses' stress and various other problems. This research aimed to identify the stress resulting from caring for cancer patients and the methods for coping with stress among cancer care nurses. The research subjects were 180 clinical nurses caring for cancer patients in a hospital in Korea. Stress caused by excessive workloads, inappropriate compensation, and interpersonal conflicts with physicians was high. There was a difference in stress according to age. Coping strategies differed according to religion, education, occupation, hospice education, job satisfaction, and leisure activities. The higher the stress, the greater the number of coping strategies used. Problem-related coping was associated with more diverse stressors. Stress characteristics differed according to various factors, whereas stress coping strategies depended on the stress characteristics of clinical nurses caring for cancer patients. Future research following a critical approach will be needed to elucidate the compassion fatigue related to the stress strategies of clinical nurses. These findings could contribute to the development of interventions to reduce stress in clinical nurses by providing evidence on the stress and coping methods of nurses who provide palliative care for cancer patients.
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- 2020
11. Development of an IoT Device for Detecting Escherichia coli from Various Agri-Foods and Production Environments
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Injun Hwang, Won-Il Kim, Kyoung-Yul Ryu, Se-Ri Kim, Hyun Ju Kim, Nguyen Bao Hung, Agro-Food Safety Microbial Safety Team, Hyeonjin Chu, and Hwang-Yong Kim
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business.industry ,medicine ,Production (economics) ,medicine.disease_cause ,Internet of Things ,business ,Escherichia coli ,Biotechnology - Published
- 2019
12. Investigation of Hazardous Microorganisms in Baby Leafy Vegetables Collected from a Korean Market and Distribution Company
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Hyeonjin Chu, Kyeongyul Ryu, Youn-Jung Jang, Won-Il Kim, Se-Ri Kim, Hyun-Ju Kim, Nguyen Bao Hung, Seung-Won Yi, and Won-Bo Shim
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Toxicology ,Hazardous waste ,business.industry ,Microorganism ,Indicator bacteria ,Environmental science ,Distribution (economics) ,Leafy vegetables ,business - Published
- 2019
13. Reducing Radiation Dermatitis Using a Film-forming Silicone Gel During Breast Radiotherapy: A Pilot Randomized-controlled Trial
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Joo-Young Roh, Young Kyu Lee, KiHoon Sung, Hyun-Ju Kim, Young Eun Choi, Seul Ki Lee, Jeong Soo Kim, and Songmi Ahn
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Adult ,Cancer Research ,medicine.medical_specialty ,Every Two Weeks ,Erythema ,Administration, Topical ,Breast Neoplasms ,Pilot Projects ,Breast radiotherapy ,General Biochemistry, Genetics and Molecular Biology ,law.invention ,Silicone Gels ,Young Adult ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,Breast cancer ,Silicone ,Randomized controlled trial ,law ,Post-hoc analysis ,medicine ,Humans ,Pharmacology ,Radiotherapy ,business.industry ,Middle Aged ,Prognosis ,medicine.disease ,Dermatology ,chemistry ,030220 oncology & carcinogenesis ,Female ,Analysis of variance ,Radiodermatitis ,medicine.symptom ,business ,Research Article ,Follow-Up Studies - Abstract
Background/Aim: To evaluate whether topical use of a film-forming silicone gel (StrataXRT(®)) could reduce radiation dermatitis compared to a moisturizing cream (X-derm(®)) in patients receiving whole breast radiotherapy. Patients and Methods: A total of 56 patients with breast cancer were randomized to use StrataXRT or X-derm. The severity of radiation dermatitis was graded using physiological skin parameters, clinician-assessed visual rating scales and patient-reported symptoms. Changes in these parameters from baseline to 4 weeks post-radiotherapy were evaluated every two weeks. Results: Two-way repeated-measures ANOVA revealed different patterns of changes in the erythema index (F=3.609, p=0.008) and melanin index (F=3.475, p=0.015). The post hoc analysis demonstrated a significantly lower erythema index and melanin index in the patients allocated to the StrataXRT group. Conclusion: The use of StrataXRT can reduce radiation dermatitis with respect to objectively measured physiological skin parameters. The results of the present study will support the feasibility of conducting a larger randomized controlled trial.
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- 2019
14. Critical Review I to Standardize the Textbooks of Fundamentals of Nursing: Vital Sign Assessment, Body Temperature Regulation, Oxygenation
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YunHee Shin, Hyun Ju Kim, and Seung Kyo Chaung
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Nursing ,business.industry ,Medicine ,Oxygenation ,business ,General Nursing ,Sign (mathematics) - Published
- 2019
15. Mobile Access Expansion and Price Information Diffusion: Firm Performance after Ethiopia'S Transition to 3G in 2008
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Maurice Kugler, Hyun Ju Kim, Jieun Choi, Kaleb Girma Abreha, and Woubet Kassa
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business.product_category ,ComputingMilieux_THECOMPUTINGPROFESSION ,media_common.quotation_subject ,Wage ,Competition (economics) ,Incentive ,Price dispersion ,Internet access ,Business ,Market share ,Total factor productivity ,Productivity ,Industrial organization ,media_common - Abstract
This paper investigates whether enhanced access to mobile communications, including internet, primarily through smart phones, increases competition as price information is more widely available to customers—both households and firms. The exogenous shock to identify these impacts is the transition from 2G to the 3G broadband network standard in 2008, and the induced changes in the geographic variation across districts of data plan availability for households. The operational mechanism is that better household and firm telecommunications access can close information asymmetry gaps between buyers and sellers, with increased competition leading to improved firm performance. Lower markups and reduced price dispersion can result from better incentives for firms to preserve and grow market share. And as price competition squeezes profit margins, there are more incentives for firms to reduce costs—inducing higher total factor productivity growth. Improved firm performance can generate jobs and economic transformation. Indeed, faster productivity growth, due to enhanced access for buyers to mobile telecommunications, can translate into higher formal employment and wages. One open question is whether the potential competition, driven by the increased mobile telecommunications access of buyers, which help them have the best alternative prices at their fingertips, will also impact export-oriented companies. The prior is that the firm performance improvement effect would be more salient for firms mostly focused on local markets. The primary data sources are manufacturing firm census data and household expenditure survey data across woredas (districts or counties) in Ethiopia. First, the paper investigates the relation between expanded access with the 3G network to price information through mobile phones (measured at the woreda level as share of households with substantive expenditure to access data through smartphones) and firm performance measures (markups, total factor productivity, labor productivity, wage growth, wage gaps and employment growth.), across districts with different shares of mobile telecommunication and data plan penetration subscription. The paper estimates models with difference-in-differences and triple differences. The evidence is consistent with competition intensification after the improvement in access to mobile communication due to the 3G network rollout. In particular, markups were reduced and there was higher growth in productivity, wages, and employment.
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- 2021
16. Transcriptomic Analysis in the Striatum Reveals an Involvement of Nurr1 in Social Behavior of Prenatally Valproic Acid-Exposed Mice
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Kim Hye-Sun, Eun hwa Jo, Seonghan Kim, Han-Byeol Kim, Eun-Jeong Yang, Ran-Sook Woo, and Hyun-Ju Kim
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Transcriptome ,Valproic Acid ,Text mining ,nervous system ,business.industry ,medicine ,Striatum ,Biology ,Pharmacology ,business ,medicine.drug - Abstract
BackgroundThe striatum of the basal ganglia is the major subcortical component of the mammalian forebrain. Magnetic resonance imaging (MRI) studies have implicated surface deformation of the striatum in the brains of patients with autism spectrum disorders (ASD) and their correlation with behavioral phenotypes. MethodsUsing RNA sequencing (RNA-Seq), we analyzed transcriptome alteration in striatal tissues from 10-week-old prenatally valproic acid (VPA)-exposed BALB/c male mice. To investigate the relationship of Nurr1 with synaptic and social deficit, we activated the expression level of nuclear receptor related 1 protein (Nurr1) by i.p. injection of amodiaquine (AQ) for 2 weeks. Furthermore, we employed lentiviral system to inhibit the Nurr1 expression and provide evidence for the role of Nurr1 in social behavior. ResultsTranscriptomic analysis showed higher levels of genes related to synaptic function of neurons in striatal tissues from the prenatally VPA-exposed mice. Among those genes, Nurr1 expression was significantly upregulated. The treatment with AQ, which has been known to be a ligand for Nurr1, to saline-exposed mice mimicked social deficits and synaptic abnormality observed in prenatally VPA-exposed mice. Moreover, viral inhibition of Nurr1 markedly improved social deficits in prenatally VPA-exposed mice. LimitationsThis study did not identify the mechanism of how Nurr1 activation regulates striatum-related circuit. Identification of the mechanism will provide explanation for behavioral impairments in prenatally VPA-exposed mice.ConclusionsTaken together, these results suggest that the increase in Nurr1 expression in the striatum is a mechanism related to the changes in synaptic deficits and behavioral phenotypes of VPA-induced ASD mouse model.
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- 2021
17. Early Trauma Is Associated With Suicidal Ideation in Patients With Panic Disorder
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Ji Eun Kim, Sang-Hyuk Lee, and Hyun-Ju Kim
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Adult ,Male ,Coping (psychology) ,medicine.medical_treatment ,Comorbidity ,Psychological Trauma ,Suicidal Ideation ,Adverse Childhood Experiences ,Medicine ,Humans ,In patient ,Suicidal ideation ,business.industry ,Panic disorder ,Beck Depression Inventory ,Panic Disorder Severity Scale ,Middle Aged ,medicine.disease ,Desensitization (psychology) ,Psychiatry and Mental health ,Anxiety sensitivity ,Panic Disorder ,Female ,medicine.symptom ,business ,Clinical psychology - Abstract
There are several predictors of suicidality in patients with panic disorder (PD). Being a woman, younger age, low education level, unmarried status, and symptom severity have been suggested. This study aimed to examine whether early trauma is associated with suicidal ideation in patients with PD. Our study included 267 patients with PD and 105 controls. Data on sociodemographic variables and data from the Early Trauma Inventory Self Report-Short Form, Beck Depression Inventory, Panic Disorder Severity Scale, Anxiety Sensitivity Inventory-Revised, Coping Scales, and Scale for Suicide Ideation were collected, and correlation and regression analyses were performed. This study suggests that clinicians should consider early trauma when assessing suicidal ideation in patients with PD. Clinicians could consider alternative treatments, such as trauma-focused cognitive-behavioral therapy, eye movement desensitization, reprocessing approaches, and classical pharmacological and psychological treatments for patients with PD who have a history of early trauma and are expected to be at high risk for suicide.
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- 2021
18. The effects of mother-child group play therapy on infant with developmental delay and mothers interaction behavior and parenting efficacy
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Hyun-Ju Kim and Hee-Won Noh
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Cultural Studies ,Group (mathematics) ,business.industry ,Play therapy ,Medicine ,business ,Education ,Developmental psychology - Published
- 2019
19. Effects of Self-efficacy and Transplant-related Knowledge on Compliance with a Therapeutic Regimen for Recipients of Liver Transplant
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So Jung Moon and Hyun-Ju Kim
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Self-efficacy ,Compliance (physiology) ,medicine.medical_specialty ,Therapeutic regimen ,business.industry ,medicine ,Intensive care medicine ,business ,General Nursing - Published
- 2019
20. Study of 《The Fable of September》
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Hyun-ju Kim
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Literature ,Fable ,business.industry ,media_common.quotation_subject ,Art ,business ,media_common - Published
- 2019
21. An Interdisciplinary Study for Analysing the User Experience of Interactive Media Art
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Hyun Ju Kim and 서울미디어대학원대학교(SMIT) 뉴미디어학부
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Interactivity ,User experience design ,Multimedia ,Computer science ,business.industry ,Ocean Engineering ,business ,computer.software_genre ,computer ,Interactive media - Published
- 2019
22. Management of Clinical T1N0M0 Esophageal Cancer
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Kyung Ran Park, Seo Hee Choi, Hwa Kyung Byun, Jinhyun Choi, Andrew Jihoon Yang, Chang Geol Lee, Sang Kil Lee, Yong Chan Lee, and Hyun-Ju Kim
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Adult ,Male ,medicine.medical_specialty ,Esophageal Neoplasms ,medicine.medical_treatment ,Endoscopic mucosal resection ,Gastroenterology ,Internal medicine ,medicine ,Humans ,Esophageal neoplasm ,Stage (cooking) ,Aged ,Neoplasm Staging ,Retrospective Studies ,Aged, 80 and over ,Radiotherapy ,Hepatology ,business.industry ,Standard treatment ,Cancer ,Chemoradiotherapy ,Middle Aged ,Esophageal cancer ,medicine.disease ,Combined Modality Therapy ,Esophagectomy ,Radiation therapy ,Treatment Outcome ,Female ,Original Article ,business - Abstract
Background/Aims: Endoscopic resection is a standard treatment for stage T1a esophageal cancer, with esophagectomy or radical radiation therapy (RT) performed for stage T1b lesions. This study aimed to compare treatment outcomes of each modality for clinical stage T1 esophageal cancer. Methods: In total, 179 patients with clinical T1N0M0- stage esophageal cancer treated from 2006 to 2016 were retrospectively evaluated. Sixty-two patients with clinical T1a-stage cancer underwent endoscopic resection. Among 117 patients with clinical T1b-stage cancer, 82 underwent esoph-agectomy, and 35 received chemoradiotherapy or RT. We compared overall survival (OS) and recurrence-free survival (RFS) rates for each treatment modality. Results: The median follow-up time was 32 months (range, 1 to 120 months). The 5-year OS and RFS rates for patients with stage T1a cancer receiving endoscopic resection were 100% and 85%, respectively. For patients with stage T1b, the 5-year OS and RFS rates were 78% and 77%, respectively, for the esophagectomy group; 80% and 44%, respectively, for the RT alone group; and 96% and 80%, respectively, for the chemoradiation group. The esophagectomy group showed significantly higher RFS than the RT alone group (p=0.04). There was no significant difference in RFS between the esophagectomy and chemoradiation groups (p=0.922). Grade 4 or higher treatment-related complications occurred in four patients who underwent esophagectomy. Conclusions: Endoscopic resection appeared to be an adequate treatment for patients with T1a-stage esophageal cancer. The multidisciplinary approach involving chemoradiation was comparable to esophagectomy in terms of survival outcome without serious complications for T1b-stage esophageal cancer. (Gut Liver 2019;13:315-324)
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- 2019
23. A Multicenter Study on von Willebrand Disease Realities in Yeungnam Region
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Hyun-Ju Kim, Ye Jee Shim, Jae Min Lee, Sang Kyu Park, Eun Jin Choi, Hyo Sun Kim, Eu Jeen Yang, Seom Gim Kong, Eun Sil Park, Ji Kyoung Park, Young Tak Lim, Kyung Mi Park, Ji Yoon Kim, and Hee Won Chueh
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lcsh:Internal medicine ,medicine.medical_specialty ,business.industry ,korea ,lcsh:RJ1-570 ,lcsh:Pediatrics ,Retrospective cohort study ,General Medicine ,lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,medicine.disease ,lcsh:RC254-282 ,von willebrand disease ,retrospective studies ,children ,Multicenter study ,hemic and lymphatic diseases ,Internal medicine ,adults ,Von Willebrand disease ,medicine ,lcsh:RC31-1245 ,business - Abstract
Background : : von Willebrand disease (VWD) is one of the most common inherited bleeding disorders. However, the number of patients who register to the Korea Hemophilia Foundation (KHF) is much lower than the expected prevalence rate and only few hospitals perform tests for diagnosis autonomously. Thus, we surveyed practical realities of VWD in Yeungnam region. Methods : : Patients with VWD (N=267) who were diagnosed at eleven university hospitals from March 1995 to March 2018 were enrolled in this study. We evaluated the medical records from each hospital retrospectively. Results : : Two hundred and twenty-eight children and 39 adults met the diagnostic criteria for VWD. Seventy-eight (57.4%) patients had the blood type O. Fifty-eight patients were definite type 1 (21.7%), 151 were possible type 1 (56.6%), and the others were type 2. Abnormal laboratory findings were the most common factor for the diagnosis in children. VWF mutations were detected in 17 patients. Patients with a family history showed age of diagnosis of 9 y, which is higher than in those with no family history (6 yr), and also showed a higher rate of significant bleeding (32.1% vs. 14.2%). VWF:RCo and VWF:Ag tests were performed in-hospital at only 1 of 11 hospitals. Twelve of 267 patients were enrolled at the KHF (4.5%). Conclusion : : A high rate of out-sourcing studies may result in inaccurate diagnosis. The registration rate to the KHF is still lower than the prevalence rate. A comprehensive nationwide registration system is necessary in order to identify the actual prevalence rate and promote the diagnosis of VWD in Korea.
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- 2019
24. Dose escalation by intensity modulated radiotherapy in liver-directed concurrent chemoradiotherapy for locally advanced BCLC stage C hepatocellular carcinoma
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Hyun-Ju Kim, Hwa Kyung Byun, Kwang Hyub Han, Jinsil Seong, Yoo Ri Im, and Do Young Kim
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Adult ,Male ,Antimetabolites, Antineoplastic ,medicine.medical_specialty ,Gastrointestinal bleeding ,Carcinoma, Hepatocellular ,medicine.medical_treatment ,Locally advanced ,Urology ,Kaplan-Meier Estimate ,030218 nuclear medicine & medical imaging ,03 medical and health sciences ,Liver disease ,Hepatic Artery ,0302 clinical medicine ,medicine ,Dose escalation ,Humans ,Infusions, Intra-Arterial ,Radiology, Nuclear Medicine and imaging ,Propensity Score ,Aged ,Neoplasm Staging ,Retrospective Studies ,Aged, 80 and over ,business.industry ,Liver Neoplasms ,Dose-Response Relationship, Radiation ,Chemoradiotherapy ,Hematology ,Middle Aged ,medicine.disease ,Radiation therapy ,Oncology ,030220 oncology & carcinogenesis ,Hepatocellular carcinoma ,Propensity score matching ,Female ,Fluorouracil ,Radiotherapy, Intensity-Modulated ,BCLC Stage C Hepatocellular Carcinoma ,business - Abstract
PURPOSE To evaluate the effects of dose escalation by intensity-modulated radiotherapy (IMRT) in liver-directed concurrent chemoradiotherapy for locally advanced Barcelona Clinic Liver Cancer stage C hepatocellular carcinoma (BCLC-C HCC). MATERIALS AND METHODS During 2005-2016, 637 patients with BCLC-C HCC received RT with concurrent hepatic arterial 5-fluorouracil. Patients were divided into two groups according to the biologically effective doses for a tumor (α/β = 10 Gy)
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- 2019
25. Applicability of Drone Mapping for Natural Disaster Damage Investigation
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Seong Sam Kim, Si Bum Cho, Hyun-Ju Kim, and Bong Geun Song
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Computer science ,business.industry ,Artificial intelligence ,business ,Drone - Abstract
자연재해가 발생하면 지자체와 정부는 재난 및 안전관리 기본법에 따라 피해상황을 신속하게 조사하여 그 피해정도를 정량적으로 분석하고 적절한 피해복구 계획을 수립해야 한다. 본 논문에서는 2018년 호우․태풍으로 산사태, 하천 범람, 저수지가 붕괴된 발생한 보성군 5개 피해지역을 대상으로 상업용 드론과 드론맵핑 기술을 활용하여 3차원 재난현장 지형정보와 정사영상 지도를 생성하고, 이를 토대로 정량적인 자연재해 피해규모를 분석하였다. 하천과 저수지 붕괴지역 피해현장에 대해 촬영고도 100~250m에서 취득된 드론 항공사진으로 지상해상도 약 2~4.9cm/픽셀의 고해상 영상지도를 제작하여 하천 시설물의 파손 정도나 토사 유출 흔적 등 현장 피해정보를 확인 할 수 있었다. 또한, 산사태 피해지역의 3차원 점군 자료를 활용하여 산사태로 인한 유출된 쇄굴 폭과 깊이, 토사유출 거리, 산사태 피해면적을 보다 정밀하게 파악하였다. 이러한 재해피해조사를 위한 드론맵핑 기술은 신속하게 재난현장을 전수 조사하는 피해조사단의 현장업무 지원 또는 대체방안이 될 수 있을 것으로 기대된다.
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- 2019
26. Clinical feasibility and efficacy of stereotactic body radiotherapy for hepatocellular carcinoma: A systematic review and meta-analysis of observational studies
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Chai Hong Rim, Jinsil Seong, and Hyun-Ju Kim
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medicine.medical_specialty ,Carcinoma, Hepatocellular ,medicine.medical_treatment ,Cochrane Library ,Radiosurgery ,Hepatic Complication ,Gastroenterology ,030218 nuclear medicine & medical imaging ,03 medical and health sciences ,0302 clinical medicine ,Internal medicine ,Humans ,Medicine ,Radiology, Nuclear Medicine and imaging ,Liver neoplasm ,Aged, 80 and over ,business.industry ,Liver Neoplasms ,Hematology ,Middle Aged ,medicine.disease ,Confidence interval ,Survival Rate ,Radiation therapy ,Oncology ,030220 oncology & carcinogenesis ,Meta-analysis ,Hepatocellular carcinoma ,Feasibility Studies ,Female ,Liver function ,business - Abstract
Background and purpose Stereotactic body radiotherapy (SBRT) is an emerging ablative modality for hepatocellular carcinoma (HCC). This study aimed to synthesize available evidence to evaluate the clinical feasibility and efficacy of SBRT for HCC. Materials and methods A systematic search was performed of the PubMed, Medline, Embase, and Cochrane Library databases. Primary endpoints were overall survival (OS) and local control (LC), and the secondary endpoint was grade ≥3 complications. Results Thirty-two studies involving 1950 HCC patients who underwent SBRT were included. Pooled 1-, 2-, and 3-year OS rates were 72.6% (95% confidence interval [CI]: 65.7–78.6), 57.8% (50.9–64.4), and 48.3% (40.3–56.5), respectively. Pooled 1-, 2-, and 3-year LC rates were 85.7% (95% CI: 80.1–90.0), 83.6% (77.4–88.3), and 83.9% (77.6–88.6), respectively. The median value of median tumor sizes among studies was 3.3 cm (range: 1.6–8.6). Median radiation doses, calculated in dose equivalent with 2 Gy per fraction, ranged from 48 to 114.8 Gy10 (median 83.3 Gy10). Subgroup comparison regarding tumor size showed significant differences for 1- and 2-year OS rates and 1-, 2-, and 3-year LC rates, and that regarding radiation dose showed no difference for OS and a marginal difference for 1-year LC rate. Pooled rates of hepatic and gastrointestinal grade ≥3 complications were 4.7% (95% CI: 3.4–6.5) and 3.9% (2.6–5.6), respectively. Child-Pugh class was significantly correlated with hepatic complication of grade ≥3 in meta-regression analysis (p = 0.013). Conclusion SBRT for HCC was a feasible option conferring excellent LC persisting up to 3 years. Both OS and LC were affected by tumor size, and radiation dose marginally affected LC. Severe complications rarely occurred, but liver function should be considered to avoid serious hepatic toxicity.
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- 2019
27. Retrospective analysis of stereotactic body radiation therapy efficacy over radiofrequency ablation for hepatocellular carcinoma
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Inkyung Jung, Kwang Hyub Han, Nalee Kim, Hyun-Ju Kim, Jinsil Seong, Do Young Kim, and Jong Yun Won
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Male ,medicine.medical_specialty ,Carcinoma, Hepatocellular ,Stereotactic body radiation therapy ,Radiofrequency ablation ,Radiosurgery ,030218 nuclear medicine & medical imaging ,law.invention ,Cohort Studies ,03 medical and health sciences ,0302 clinical medicine ,law ,Clinical endpoint ,Retrospective analysis ,Humans ,Medicine ,Radiology, Nuclear Medicine and imaging ,Propensity Score ,Proportional Hazards Models ,Retrospective Studies ,Radiofrequency Ablation ,business.industry ,Liver Neoplasms ,Hematology ,Middle Aged ,medicine.disease ,Treatment Outcome ,Oncology ,030220 oncology & carcinogenesis ,Hepatocellular carcinoma ,Propensity score matching ,Disease Progression ,Female ,Radiology ,business ,Stereotactic body radiotherapy ,Treatment Arm - Abstract
To evaluate the efficacy of stereotactic body radiotherapy (SBRT) and radiofrequency ablation (RFA) for hepatocellular carcinoma (HCC).Patients treated for HCC between 2012 and 2016 were reviewed. Among these, 668 patients who underwent RFA of 736 tumors and 105 patients who underwent SBRT of 114 tumors were included. Using propensity score matching (PSM) to adjust for clinical factors, 95 tumors were selected from each treatment arm. Freedom from local progression (the primary endpoint, FFLP) was compared before and after adjustment with PSM.At baseline, SBRT-treated tumors were more advanced, larger (median, 2.4 vs. 1.6 cm), and more frequently located in the subphrenic region than RFA-treated tumors (P .001). The median follow-up was 21.5 (interquartile range, 11.2-36.7) months. Before PSM, the 2-year FFLP rates were 76.3% for the SBRT group and 70.2% for the RFA groups, respectively. After PSM, the 2-year FFLP rates were 74.9% for the SBRT group and 64.9% for the RFA group, respectively. The local control rates were not significantly different. The Cox proportional hazards model revealed the treatment modality as an independent predictor of local recurrence favoring SBRT in the entire cohort and in the PSM model. Elevated tumor markers, tumor location (subphrenic region), and tumor size (2.0 cm) were also independent predictors of local progression.SBRT appears to be an effective alternative treatment for HCC when RFA is not feasible due to tumor location or size.
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- 2019
28. A Study on the Transformation Patterns of Traditional Korean Folktale in ‘Old Tale’ of Injeongru
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Hyun-Ju Kim
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Literature ,History ,business.industry ,business ,Transformation (music) - Published
- 2018
29. Periodontal biotype modification using a volume-stable collagen matrix and autogenous subepithelial connective tissue graft for the treatment of gingival recession: a case series
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Sungtae Kim, Yang-Jo Seol, Hyun-Ju Kim, Hyeyoon Chang, and Hyeongil Kim
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medicine.medical_specialty ,medicine.medical_treatment ,Dentistry ,Connective tissue ,Subepithelial connective tissue graft ,Case Report ,Gingival recession ,030207 dermatology & venereal diseases ,03 medical and health sciences ,0302 clinical medicine ,Scaling and root planing ,Medicine ,Reduction (orthopedic surgery) ,Transplantation ,business.industry ,030206 dentistry ,Plastic surgery ,medicine.anatomical_structure ,Coronal plane ,Periodontics ,Oral Surgery ,medicine.symptom ,business - Abstract
Purpose The purpose of this study was to propose a technique for periodontal biotype modification through thickening of the entire facial aspect using a volume-stable collagen matrix and autogenous subepithelial connective tissue graft (CTG) for the treatment of gingival recession. Methods Four systemically healthy patients showing Miller class I or class II gingival recession in the mandibular incisor area were included in this study. Full-mouth scaling and root planing procedures were performed at least 4 weeks prior to periodontal plastic surgery. A split-thickness flap with a horizontal intrasulcular incision and 2 vertical incisions was used in cases 1–3, and the modified tunnel technique was used in case 4 for coronal advancement of the mucogingival complex. After the exposed root surfaces were debrided thoroughly, double-layered volume-stable collagen matrix was placed on the apical part of the recession and a subepithelial CTG harvested from the palatal area was placed on the coronal part. The amount of root coverage at 3 months postoperatively was evaluated in cases 1–3, and facio-lingual volumetric changes were analyzed in cases 1 and 2. Results Healing was uneventful in all 4 cases and complete root coverage was shown in cases 1–3. In case 4, reduction of gingival recession was observed at 3 months after surgery. In cases 1 and 2, a comparison of stereolithographic files from the preoperative and postoperative time points demonstrated that the entire facio-lingual volume had increased. Conclusions The surgical technique suggested herein, using a volume-stable collagen matrix and autogenous subepithelial CTG, may be an effective method for periodontal biotype modification through thickening of the entire facial aspect for the treatment of gingival recession., Graphical Abstract
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- 2018
30. Central Nervous System Failure in Korean Breast Cancer Patients with HER2-Enriched Subtype: Korean Radiation Oncology Group 16-15 Multicenter Retrospective Study
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In Ah Kim, Kyubo Kim, Hyun-Ju Kim, Won Park, Kyung Hwan Shin, Yong Bae Kim, Do Hoon Oh, Doo Ho Choi, Jiyoung Kim, Jin Ho Kim, Hyeli Park, Jinhee Kim, and Sun Young Lee
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0301 basic medicine ,Oncology ,Cancer Research ,medicine.medical_specialty ,Lymphovascular invasion ,medicine.medical_treatment ,03 medical and health sciences ,0302 clinical medicine ,Breast cancer ,Trastuzumab ,Internal medicine ,medicine ,Chemotherapy ,Radiotherapy ,business.industry ,Hazard ratio ,Retrospective cohort study ,medicine.disease ,ERBB2 protein ,Radiation therapy ,030104 developmental biology ,Central nervous system neoplasms ,030220 oncology & carcinogenesis ,Original Article ,Breast neoplasms ,business ,Mastectomy ,medicine.drug - Abstract
Purpose The purpose of this study was to evaluate the risk of central nervous system (CNS) failure in Korean patients with human epidermal growth factor receptor 2 (HER2)-enriched breast cancer treated with surgery followed by postoperative radiotherapy (RT). Methods A total of 749 patients from eight institutions were enrolled in this study. All of them underwent surgery followed by postoperative RT from 2003 to 2011; 246 (32.8%) received neoadjuvant chemotherapy and 649 (81.7%) received adjuvant chemotherapy. Adjuvant trastuzumab was administered to 386 patients (48.6%). Results The median follow-up duration was 84 (range, 8-171) months. The 7-year disease-free and overall survival rates were 79.0% and 84.2%, respectively. On multivariate analysis, mastectomy, nodal involvement, and presence of lymphatic invasion were correlated with poor overall survival (p = 0.004, 0.022, and 0.011, respectively), whereas T stage and lymphatic invasion were associated with disease-free survival (p = 0.018 and 0.005, respectively). Regarding CNS failures, 30 brain metastases, 2 leptomeningeal metastases, and 8 brain and leptomeningeal metastases were noted. The 7-year CNS relapse-free survival rates in patients receiving and not receiving trastuzumab were 91.2% and 96.9%, respectively (p = 0.005). On multivariate analysis, the administration of adjuvant trastuzumab was the only prognostic factor in predicting a higher CNS failure rate (hazard ratio, 2.260; 95% confidence interval, 1.076-4.746; p = 0.031). Conclusion Adjuvant trastuzumab was associated with higher CNS failure rate in Korean patients with HER2-enriched breast cancer. Close monitoring and reasonable approaches such as CNS penetrating HER2 blockades combined with the current standard therapy could contribute to improving intracranial tumor control and quality of life in patients with CNS metastasis from HER2-enriched breast cancer.
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- 2018
31. Nurses’ Compliance with Safety Guidelines for the Use of Antineoplastic Agents, Observable Symptoms, and Stress from Occupational Exposure
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Seon-Ja Park and Hyun Ju Kim
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medicine.medical_specialty ,030504 nursing ,business.industry ,Compliance (psychology) ,Safety guidelines ,03 medical and health sciences ,0302 clinical medicine ,030220 oncology & carcinogenesis ,medicine ,Occupational exposure ,0305 other medical science ,Intensive care medicine ,business ,General Nursing - Published
- 2018
32. Radiotherapy is a safe and effective salvage treatment for recurrent cervical cancer
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Gwi Eon Kim, Woong Sub Koom, Jee Suk Chang, Kyu Chan Lee, Hyun-Ju Kim, and Yong Bae Kim
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Adult ,0301 basic medicine ,medicine.medical_specialty ,medicine.medical_treatment ,Salvage treatment ,Uterine Cervical Neoplasms ,Recurrent cervical cancer ,Salvage therapy ,Metastatic tumor ,03 medical and health sciences ,0302 clinical medicine ,medicine ,Humans ,In patient ,Aged ,Neoplasm Staging ,Aged, 80 and over ,Salvage Therapy ,Cervical cancer ,business.industry ,Obstetrics and Gynecology ,Cancer ,Middle Aged ,Prognosis ,medicine.disease ,Radiation therapy ,030104 developmental biology ,Oncology ,030220 oncology & carcinogenesis ,Female ,Radiotherapy, Intensity-Modulated ,Radiology ,Neoplasm Recurrence, Local ,business - Abstract
Objective The feasibility of salvage radiotherapy (RT) for patients with recurrent cervical cancer after definitive treatment is contentious. The purpose of this study was to investigate the feasibility and benefit of RT, particularly intensity-modulated RT (IMRT), for salvage treatment in patients with recurrent cervical cancer. Methods We retrospectively analyzed 125 patients with recurrent cervical cancer treated with RT at Yonsei Cancer Center between January 2007 and December 2016. All patients received salvage RT for the recurred or metastatic tumor mass. Irradiating dose and volume were determined depending on initial treatment. IMRT was selected in challenging cases, such as re-irradiation or for patients for whom implementing a satisfactory 3-dimensional conformal RT plan was challenging. Results The median follow-up period was 5.5 years (range, 10.8 months to 41 years). The 5-year local failure-free survival (LFFS) and progression-free survival (PFS) rates were 63.9% and 39.6%, respectively. The 5-year overall survival (OS) rate was 66%; 10-year OS reached 51%. The median PFS rates in patients with locoregional failure, distant metastases, or both were 45.4, 29.1, and 14.7 months, respectively (p = 0.005). For the 45 patients that received re-irradiation, 5-year LFFS, PFS, and OS rates were 47.1%, 33.2%, and 66.5%, respectively. Late complications were observed in 12 patients (12/125, 9.6%). Conclusions Our data suggest that salvage RT is safe and effective against recurrent cervical cancer. IMRT is a safe and effective salvage modality for these patients, including those requiring re-irradiation.
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- 2018
33. Risk profiles and one-year outcomes of patients with newly diagnosed atrial fibrillation in India: Insights from the GARFIELD-AF Registry
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Jitendra PS. Sawhney, Veerappa A. Kothiwale, Vikas Bisne, Rajashekhar Durgaprasad, Praveen Jadhav, Manoj Chopda, Velam Vanajakshamma, Ramdhan Meena, Govindan Vijayaraghavan, Kamaldeep Chawla, Jagan Allu, Karen S. Pieper, A. John Camm, Ajay K. Kakkar, Jean-Pierre Bassand, David A. Fitzmaurice, Samuel Z. Goldhaber, Shinya Goto, Sylvia Haas, Werner Hacke, Lorenzo G. Mantovani, Frank Misselwitz, Alexander G.G. Turpie, Martin van Eickels, Freek W.A. Verheugt, Gloria Kayani, Keith A.A. Fox, Bernard J. Gersh, Hector Lucas Luciardi, Harry Gibbs, Marianne Brodmann, Frank Cools, Antonio Carlos Pereira Barretto, Stuart J. Connolly, Alex Spyropoulos, John Eikelboom, Ramon Corbalan, Dayi Hu, Petr Jansky, Jørn Dalsgaard Nielsen, Hany Ragy, Pekka Raatikainen, Jean-Yves Le Heuzey, Harald Darius, Matyas Keltai, Sanjay Kakkar, Jitendra Pal Singh Sawhney, Giancarlo Agnelli, Giuseppe Ambrosio, Yukihiro Koretsune, Carlos Jerjes Sánchez Díaz, Hugo Ten Cate, Dan Atar, Janina Stepinska, Elizaveta Panchenko, Toon Wei Lim, Barry Jacobson, Seil Oh, Xavier Viñolas, Marten Rosenqvist, Jan Steffel, Pantep Angchaisuksiri, Ali Oto, Alex Parkhomenko, Wael Al Mahmeed, David Fitzmaurice, D.Y. Hu, K.N. Chen, Y.S. Zhao, H.Q. Zhang, J.Z. Chen, S.P. Cao, D.W. Wang, Y.J. Yang, W.H. Li, Y.H. Yin, G.Z. Tao, P. Yang, Y.M. Chen, S.H. He, Ying Wang, Yong Wang, G.S. Fu, X. Li, T.G. Wu, X.S. Cheng, X.W. Yan, R.P. Zhao, M.S. Chen, L.G. Xiong, P. Chen, Y. Jiao, Y. Guo, L. Xue, F.Z. Wang, H. Li, Z.M. Yang, C.L. Bai, J. Chen, J.Y. Chen, X. Chen, S. Feng, Q.H. Fu, X.J. Gao, W.N. Guo, R.H. He, X.A. He, X.S. Hu, X.F. Huang, B. Li, J. Li, L. Li, Y.H. Li, T.T. Liu, W.L. Liu, Y.Y. Liu, Z.C. Lu, X.L. Luo, T.Y. Ma, J.Q. Peng, X. Sheng, X.J. Shi, Y.H. Sun, G. Tian, K. Wang, L. Wang, R.N. Wu, Q. Xie, R.Y. Xu, J.S. Yang, L.L. Yang, Q. Yang, Y. Ye, H.Y. Yu, J.H. Yu, T. Yu, H. Zhai, Q. Zhan, G.S. Zhang, Q. Zhang, R. Zhang, Y. Zhang, W.Y. Zheng, B. Zhou, Z.H. Zhou, X.Y. Zhu, S. Kakkar, J.P.S. Sawhney, P. Jadhav, R. Durgaprasad, A.G. Ravi Shankar, R.K. Rajput, K. Bhargava, R. Sarma, A. Srinivas, D. Roy, U.M. Nagamalesh, M. Chopda, R. Kishore, G. Kulkarni, P. Chandwani, R.A. Pothiwala, M. Padinhare Purayil, S. Shah, K. Chawla, V.A. Kothiwale, B. Raghuraman, G. Vijayaraghavan, V.M. Vijan, G. Bantwal, V. Bisne, A. Khan, J.B. Gupta, S. Kumar, D. Jain, S. Abraham, D. Adak, A. Barai, H. Begum, P. Bhattacharjee, M. Dargude, D. Davies, B. Deshpande, P. Dhakrao, V. Dhyani, S. Duhan, M. Earath, A. Ganatra, S. Giradkar, V. Jain, R. Karthikeyan, L. Kasala, S. Kaur, S. Krishnappa, A. Lawande, B. Lokesh, N. Madarkar, R. Meena, P. More, D. Naik, K. Prashanth, M. Rao, N.M. Rao, N. Sadhu, D. Shah, M. Sharma, P. Shiva, S. Singhal, S. Suresh, V. Vanajakshamma, S.G. Panse, Y. Koretsune, S. Kanamori, K. Yamamoto, K. Kumagai, Y. Katsuda, K. Sadamatsu, F. Toyota, Y. Mizuno, I. Misumi, H. Noguchi, S. Ando, T. Suetsugu, M. Minamoto, Hiroshi Oda, K. Shiraishi, S. Adachi, K. Chiba, H. Norita, M. Tsuruta, T. Koyanagi, H. Ando, T. Higashi, K. Okada, S. Azakami, S. Komaki, K. Kumeda, T. Murayama, J. Matsumura, Y. Oba, R. Sonoda, K. Goto, K. Minoda, Y. Haraguchi, H. Suefuji, H. Miyagi, H. Kato, Tadashi Nakamura, Tsugihiro Nakamura, H. Nandate, R. Zaitsu, Yoshihisa Fujiura, A. Yoshimura, H. Numata, J. Ogawa, H. Tatematsu, Y. Kamogawa, K. Murakami, Y. Wakasa, M. Yamasawa, H. Maekawa, S. Abe, H. Kihara, S. Tsunoda, Katsumi Saito, Kazuyuki Saito, T. Fudo, K. Obunai, H. Tachibana, I. Oba, T. Kuwahata, S. Higa, M. Gushiken, T. Eto, H. Yoshida, D. Ikeda, Yoshitake Fujiura, M. Ishizawa, M. Nakatsuka, K. Murata, C. Ogurusu, M. Shimoyama, M. Akutsu, I. Takamura, F. Hoshino, N. Yokota, T. Iwao, K. Tsuchida, M. Takeuchi, Y. Hatori, Y. Kitami, Yoichi Nakamura, R. Oyama, M. Ageta, Hiroyuki Oda, Y. Go, K. Mishima, T. Unoki, S. Morii, Yuhei Shiga, H. Sumi, T. Nagatomo, K. Sanno, K. Fujisawa, Y. Atsuchi, T. Nagoshi, T. Seto, T. Tabuchi, M. Kameko, K. Nii, K. Oshiro, H. Takezawa, S. Nagano, N. Miyamoto, M. Iwaki, Yuichiro Nakamura, M. Fujii, M. Okawa, Masahiko Abe, Masatake Abe, Mitsunori Abe, T. Saito, T. Mito, K. Nagao, J. Minami, T. Mita, I. Sakuma, T. Taguchi, S. Marusaki, H. Doi, M. Tanaka, T. Fujito, M. Matsuta, T. Kusumoto, S. Kakinoki, K. Ashida, N. Yoshizawa, J. Agata, O. Arasaki, M. Manita, M. Ikemura, S. Fukuoka, H. Murakami, S. Matsukawa, Y. Hata, T. Taniguchi, T. Ko, H. Kubo, M. Imamaki, M. Akiyama, M. Inagaki, H. Odakura, T. Ueda, Y. Katsube, A. Nakata, H. Watanabe, M. Techigawara, M. Igarashi, K. Taga, T. Kimura, S. Tomimoto, M. Shibuya, M. Nakano, K. Ito, T. Seo, S. Hiramitsu, H. Hosokawa, M. Hoshiai, M. Hibino, K. Miyagawa, Hajime Horie, N. Sugishita, Yukio Shiga, A. Soma, K. Neya, Tetsuro Yoshida, Tomoki Yoshida, M. Mizuguchi, M. Ishiguro, T. Minagawa, M. Wada, H. Mukawa, F. Okuda, S. Nagasaka, Y. Abe, Sen Adachi, Susumu Adachi, T. Adachi, K. Akahane, T. Amano, K. Aoki, T. Aoyama, H. Arai, S. Arima, T. Arino, H. Asano, T. Asano, J. Azuma, T. Baba, T. Betsuyaku, H. Chibana, H. Date, J. Doiuchi, Y. Emura, M. Endo, Y. Fujii, R. Fujiki, A. Fujisawa, Y. Fujisawa, T. Fukuda, T. Fukui, N. Furukawa, T. Furukawa, W. Furumoto, T. Goto, M. Hamaoka, N. Hanazono, K. Hasegawa, T. Hatsuno, Y. Hayashi, K. Higuchi, K. Hirasawa, H. Hirayama, M. Hirose, S. Hirota, M. Honda, Hideki Horie, T. Ido, O. Iiji, H. Ikeda, K. Ikeda, K. Ikeoka, M. Imaizumi, H. Inaba, T. Inoue, F. Iseki, A. Ishihara, N. Ishioka, N. Ito, T. Iwase, H. Kakuda, J. Kamata, H. Kanai, H. Kanda, M. Kaneko, H. Kano, T. Kasai, T. Kato, Y. Kato, Y. Kawada, K. Kawai, K. Kawakami, S. Kawakami, T. Kawamoto, S. Kawano, J. Kim, T. Kira, H. Kitazawa, H. Kitazumi, T. Kito, T. Kobayashi, T. Koeda, J. Kojima, H. Komatsu, I. Komatsu, Y. Koshibu, T. Kotani, T. Kozuka, Y. Kumai, T. Kumazaki, I. Maeda, K. Maeda, Y. Maruyama, S. Matsui, K. Matsushita, Y. Matsuura, K. Mineoi, H. Mitsuhashi, N. Miura, S. Miyaguchi, S. Miyajima, H. Miyamoto, A. Miyashita, S. Miyata, I. Mizuguchi, A. Mizuno, T. Mori, O. Moriai, K. Morishita, O. Murai, Sho Nagai, Shunichi Nagai, E. Nagata, H. Nagata, A. Nakagomi, S. Nakahara, M. Nakamura, R. Nakamura, N. Nakanishi, T. Nakayama, R. Nakazato, T. Nanke, J. Nariyama, Y. Niijima, H. Niinuma, Y. Nishida, Y. Nishihata, K. Nishino, H. Nishioka, K. Nishizawa, I. Niwa, K. Nomura, S. Nomura, M. Nozoe, T. Ogawa, N. Ohara, M. Okada, K. Okamoto, H. Okita, M. Okuyama, H. Ono, T. Ono, Y. Onuki Pearce, S. Oriso, A. Ota, E. Otaki, Y. Saito, H. Sakai, N. Sakamoto, Y. Sakamoto, Y. Samejima, Y. Sasagawa, H. Sasaguri, A. Sasaki, T. Sasaki, Kazuki Sato, Kiyoharu Sato, M. Sawano, S. Seki, Y. Sekine, Y. Seta, K. Sezaki, N. Shibata, Y. Shiina, H. Shimono, Y. Shimoyama, T. Shindo, H. Shinohara, R. Shinohe, T. Shinozuka, T. Shirai, T. Shiraiwa, Y. Shozawa, T. Suga, C. Sugimoto, Kazuo Suzuki, Keita Suzuki, Shu Suzuki, Shunji Suzuki, Susumu Suzuki, Y. Suzuki, M. Tada, A. Taguchi, T. Takagi, Y. Takagi, K. Takahashi, S. Takahashi, H. Takai, C. Takanaka, S. Take, H. Takeda, K. Takei, K. Takenaka, T. Tana, G. Tanabe, K. Taya, H. Teragawa, S. Tohyo, S. Toru, Y. Tsuchiya, T. Tsuji, K. Tsuzaki, H. Uchiyama, O. Ueda, Y. Ueyama, N. Wakaki, T. Wakiyama, T. Washizuka, M. Watanabe, T. Yamada, T. Yamagishi, H. Yamaguchi, Kenichi Yamamoto, Kentaro Yamamoto, Kunihiko Yamamoto, T. Yamamoto, M. Yamaura, M. Yamazoe, K. Yasui, Y. Yokoyama, K. Yoshida, T.W. Lim, C.K. Ching, C.G. Foo, J.H. Chow, D.D. Chen, F.R. Jaufeerally, Y.M. Lee, G. Lim, W.T. Lim, S. Thng, S.Y. Yap, C. Yeo, S. Oh, H.N. Pak, J.-B. Kim, J.H. Kim, S.-W. Jang, D.H. Kim, D.R. Ryu, S.W. Park, D.-K. Kim, D.J. Choi, Y.S. Oh, M.-C. Cho, S.-H. Kim, H.-K. Jeon, D.-G. Shin, J.S. Park, H.K. Park, S.-J. Han, J.H. Sung, J.-G. Cho, G.-B. Nam, Y.K. On, H.E. Lim, J.J. Kwak, T.-J. Cha, T.J. Hong, S.H. Park, J.H. Yoon, N.-H. Kim, K.-S. Kim, B.C. Jung, G.-S. Hwang, C.-J. Kim, D.B. Kim, J.J. Ahn, H.J. An, H. Bae, A.L. Baek, W.J. Chi, E.A. Choi, E.H. Choi, H.K. Choi, H.S. Choi, S. Han, E.S. Heo, K.O. Her, S.W. Hwang, E.M. Jang, H.-S. Jang, S. Jang, H.-G. Jeon, S.R. Jeon, Y.R. Jeon, H.K. Jeong, I.-A. Jung, Hyeon Jeong Kim, Hyun Ju Kim, Ji Seon Kim, Jung Sook Kim, J.A. Kim, K.T. Kim, M.S. Kim, Sang Hee Kim, Sang Hyun Kim, Y.-I. Kim, C.S. Lee, E.H. Lee, G.H. Lee, H.Y. Lee, H.-Y. Lee, K.H. Lee, K.R. Lee, M.S. Lee, M.-Y. Lee, R.W. Lee, S.E. Lee, S.H. Lee, S. Lee, W.Y. Lee, I.K. Noh, A.R. Park, B.R. Park, H.N. Park, J.H. Park, M. Park, Y. Park, S.-Y. Seo, J. Shim, J.H. Sim, Y.M. Sohn, W.S. Son, Y.S. Son, H.J. Song, H.K. Wi, J.J. Woo, S. Ye, K.H. Yim, K.M. Yoo, E.J. Yoon, S.Y. Yun, P. Angchaisuksiri, S. Chawanadelert, P. Mongkolwongroj, K. Kanokphatcharakun, S. Cheewatanakornkul, T. Laksomya, S. Pattanaprichakul, T. Chantrarat, S. Rungaramsin, S. Silaruks, W. Wongcharoen, K. Siriwattana, K. Likittanasombat, P. Katekangplu, W. Boonyapisit, D. Cholsaringkarl, B. Chatlaong, P. Chattranukulchai, Y. Santanakorn, P. Hutayanon, P. Khunrong, T. Bunyapipat, S. Jai-Aue, P. Kaewsuwanna, P. Bamungpong, S. Gunaparn, S. Hongsuppinyo, R. Inphontan, R. Khattaroek, K. Khunkong, U. Kitmapawanont, C. Kongsin, B. Naratreekoon, S. Ninwaranon, J. Phangyota, A. Phrommintikul, P. Phunpinyosak, K. Pongmorakot, S. Poomiphol, N. Pornnimitthum, S. Pumprueg, S. Ratchasikaew, K. Sanit, K. Sawanyawisuth, B. Silaruks, R. Sirichai, A. Sriwichian, W. Suebjaksing, P. Sukklad, T. Suttana, A. Tangsirira, O. Thangpet, W. Tiyanon, Y. Vorasettakarnkij, T. Wisaratapong, W. Wongtheptien, A. Wutthimanop, S. Yawila, A. Oto, A. Altun, I. Ozdogru, K. Ozdemir, O. Yilmaz, A. Aydinlar, M.B. Yilmaz, E. Yeter, Z. Ongen, M. Cayli, H. Pekdemir, M. Ozdemir, M. Sucu, T. Sayin, M. Demir, H. 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Registrie ,Male ,Time Factors ,Anticoagulant therapy, Arrhythmia, Atrial fibrillation, GARFIELD-AF ,030204 cardiovascular system & hematology ,Electrocardiography ,0302 clinical medicine ,Risk Factors ,Anticoagulant therapy ,Arrhythmia ,Atrial fibrillation ,GARFIELD-AF ,Aged ,Atrial Fibrillation ,Female ,Follow-Up Studies ,Humans ,Incidence ,India ,Prevalence ,Prognosis ,Prospective Studies ,Survival Rate ,Thromboembolism ,Registries ,Risk Assessment ,Medicine ,030212 general & internal medicine ,Prospective cohort study ,Incidence (epidemiology) ,cardiovascular system ,medicine.symptom ,Cardiology and Cardiovascular Medicine ,Risk assessment ,Human ,medicine.medical_specialty ,Time Factor ,RD1-811 ,Prognosi ,Follow-Up Studie ,03 medical and health sciences ,Internal medicine ,Diseases of the circulatory (Cardiovascular) system ,cardiovascular diseases ,Risk factor ,Survival rate ,Fibrillation ,business.industry ,Risk Factor ,ta3121 ,medicine.disease ,Clinical trial ,Prospective Studie ,RC666-701 ,Surgery ,Clinical and Preventive Cardiology ,business - Abstract
Background: The Global Anticoagulant Registry in the FIELD–Atrial Fibrillation (GARFIELD-AF) is an ongoing prospective noninterventional registry, which is providing important information on the baseline characteristics, treatment patterns, and 1-year outcomes in patients with newly diagnosed non-valvular atrial fibrillation (NVAF). This report describes data from Indian patients recruited in this registry. Methods and results: A total of 52,014 patients with newly diagnosed AF were enrolled globally; of these, 1388 patients were recruited from 26 sites within India (2012–2016). In India, the mean age was 65.8 years at diagnosis of NVAF. Hypertension was the most prevalent risk factor for AF, present in 68.5% of patients from India and in 76.3% of patients globally (P
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- 2018
34. Patterns of Locoregional Recurrence after Radical Cystectomy for Stage T3-4 Bladder Cancer: A Radiation Oncologist's Point of View
- Author
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Jaehee Chun, Jae Hee Cheon, Won Sik Ham, Hyun Ju Kim, Tae Hyung Kim, Woong Sub Koom, Jin Sung Kim, Gowoon Yang, Sang Joon Shin, and Jaemoon Yang
- Subjects
medicine.medical_specialty ,recurrence ,medicine.medical_treatment ,Perineural invasion ,Locally advanced ,Planning target volume ,030204 cardiovascular system & hematology ,Cystectomy ,03 medical and health sciences ,0302 clinical medicine ,cystectomy ,medicine ,Humans ,Stage (cooking) ,Radiation oncologist ,Retrospective Studies ,Adjuvant radiotherapy ,Bladder cancer ,business.industry ,Radiation Oncologists ,General Medicine ,medicine.disease ,Urinary Bladder Neoplasms ,Oncology ,030220 oncology & carcinogenesis ,Original Article ,Radiology ,Neoplasm Recurrence, Local ,business ,adjuvant radiotherapy - Abstract
PURPOSE Adjuvant radiotherapy (RT) has been performed to reduce locoregional failure (LRF) following radical cystectomy for locally advanced bladder cancer; however, its efficacy has not been well established. We analyzed the locoregional recurrence patterns of post-radical cystectomy to identify patients who could benefit from adjuvant RT and determine the optimal target volume. MATERIALS AND METHODS We retrospectively reviewed 160 patients with stage ≥ pT3 bladder cancer who were treated with radical cystectomy between January 2006 and December 2015. The impact of pathologic findings, including the stage, lympho-vascular invasion, perineural invasion, margin status, nodal involvement, and the number of nodes removed on failure patterns, was assessed. RESULTS Median follow-up period was 27.7 months. LRF was observed in 55 patients (34.3%), 12 of whom presented with synchronous local and regional failures as the first failure. The most common failure pattern was distant metastasis (40%). Among LRFs, the most common recurrence site was the cystectomy bed (15.6%). Patients with positive resection margins had a significantly higher recurrence rate compared to those without (28% vs. 10%, p=0.004). The pelvic nodal recurrence rate was < 5% in pN0 patients; the rate of recurrence in the external and common iliac nodes was 12.5% in pN+ patients. The rate of recurrence in the common iliac nodes was significantly higher in pN2-3 patients than in pN0-1 patients (15.2% vs. 4.4%, p=0.04). CONCLUSION Pelvic RT could be beneficial especially for those with positive resection margins or nodal involvement after radical cystectomy. Radiation fields should be optimized based on the patient-specific risk factors.
- Published
- 2021
35. Comparison of upper and lower body forced air blanket to prevent perioperative hypothermia in patients who underwent spinal surgery in prone position: a randomized controlled trial
- Author
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Yun Jeong Choi, Sun Young Park, Si Young Ok, Ji Won Chung, Ho Bum Cho, Sang Hoon Song, Sang Ho Kim, Hong Chul Oh, Jae Hwa Yoo, Mun Gyu Kim, and Hyun-Ju Kim
- Subjects
Hypothermia ,Anesthesia, General ,Pacu ,law.invention ,Body Temperature ,spine surgery ,Patient satisfaction ,Randomized controlled trial ,Anesthesiology ,law ,Prone Position ,Medicine ,Humans ,forced-air warming ,RD78.3-87.3 ,biology ,business.industry ,upper body ,Shivering ,Perioperative ,biology.organism_classification ,Prone position ,Anesthesiology and Pain Medicine ,lower body ,Anesthesia ,Intraoperative Period ,medicine.symptom ,business - Abstract
Background: We compared upper- and lower-body forced-air blankets in terms of their ability to prevent perioperative hypothermia, defined as a reduction in body temperature to < 36.0°C, during the perioperative period in patients undergoing spine surgery in the prone position.Methods: In total, 120 patients scheduled for elective spine surgery under general anesthesia were divided into an upper-warming group (n = 60) and a lower-warming group (n = 60). After inducing anesthesia and preparing the patient for surgery, including prone positioning, the upper and lower bodies of the patients in the upper- and lower-warming groups, respectively, were warmed using a forced-air warmer with specified upper and lower blankets. Body temperature was measured using a tympanic membrane thermometer during the pre- and post-operative periods and using a nasopharyngeal temperature probe during the intraoperative period. Patients were evaluated in terms of shivering, thermal comfort, and satisfaction in the post-anesthesia care unit (PACU).Results: The incidence of intraoperative and postoperative hypothermia was lower in the upper-warming group than in the lower-warming group ([55.2% vs. 75.9%, P = 0.019] and [21.4% vs. 49.1%, P = 0.002]). Perioperative body temperature was higher in the upper-warming group (P < 0.001). However, intraoperative blood loss, postoperative thermal comfort scale and shivering scores, patient satisfaction, and PACU duration were similar in the two groups.Conclusions: The upper-body blanket was more effective than the lower-body blanket for preventing perioperative hypothermia in patients who underwent spine surgery in the prone position.
- Published
- 2021
36. PO-1196 Role of prophylactic cranial irradiation in limited and extensive-stage small cell lung cancer
- Author
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Changhoon Song, Y.J. Lim, and Hyun-Ju Kim
- Subjects
Pathology ,medicine.medical_specialty ,Oncology ,business.industry ,Medicine ,Radiology, Nuclear Medicine and imaging ,Hematology ,Prophylactic cranial irradiation ,business ,Extensive-stage small cell lung cancer - Published
- 2021
37. Potential Interplay between Nrf2, TRPA1, and TRPV1 in Nutrients for the Control of COVID-19
- Author
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Désirée Larenas-Linnemann, Jacques Reynes, Josep M. Antó, Juan Carlos Ivancevich, Nieves Pizarro Lozano, Vincent Le Moing, Torsten Zuberbier, Adrian R. Martineau, Susana C. Fonseca, Wienczyslawa Czarlewski, Frederico S. Regateiro, Ludger Klimek, Sanna Toppila-Salmi, Hak Jong Choi, Erik Melén, Arunas Valiulis, Piotr Kuna, Helga Kraxner, Cezmi A. Akdis, G. Walter Canonica, Yoshitaka Okamoto, Marek Jutel, Nikolaos G. Papadopoulos, Joaquim Mullol, Bilun Gemicioglu, Philip W. Rouadi, Hubert Blain, Guido Iaccarino, Bolesław Samoliński, Alessandro Fiocchi, Rafael de la Torre, Oliver Pfaar, Jean Bousquet, Aziz Sheikh, Yves Rolland, Tari Haahtela, João Fonseca, Hyun Ju Kim, Alvaro A. Cruz, Anna Bedbrook, Jean-Paul Cristol, Ioana Agache, Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046] (PhyMedExp), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Bousquet, J., Czarlewski, W., Zuberbier, T., Mullol, J., Blain, H., Cristol, J. -P., De La Torre, R., Pizarro Lozano, N., Le Moing, V., Bedbrook, A., Agache, I., Akdis, C. A., Canonica, G. W., Cruz, A. A., Fiocchi, A., Fonseca, J. A., Fonseca, S., Gemicioglu, B., Haahtela, T., Iaccarino, G., Ivancevich, J. C., Jutel, M., Klimek, L., Kraxner, H., Kuna, P., Larenas-Linnemann, D. E., Martineau, A., Melen, E., Okamoto, Y., Papadopoulos, N. G., Pfaar, O., Regateiro, F. S., Reynes, J., Rolland, Y., Rouadi, P. W., Samolinski, B., Sheikh, A., Toppila-Salmi, S., Valiulis, A., Choi, H. -J., Kim, H. J., Anto, J. M., and Université de Montpellier (UM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)
- Subjects
Taste ,medicine.medical_treatment ,Oxytocin ,Severity of Illness Index ,[SDV.MHEP.PSR]Life Sciences [q-bio]/Human health and pathology/Pulmonology and respiratory tract ,[SDV.IMM.II]Life Sciences [q-bio]/Immunology/Innate immunity ,Antioxidants ,Transient receptor potential channel ,0302 clinical medicine ,COVID-19 Testing ,[SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases ,Immunology and Allergy ,030223 otorhinolaryngology ,TRPA1 Cation Channel ,Clinical Immunology − Letter to the Editor ,Desensitization (medicine) ,[SDV.MHEP.ME]Life Sciences [q-bio]/Human health and pathology/Emerging diseases ,musculoskeletal, neural, and ocular physiology ,food and beverages ,General Medicine ,3. Good health ,Up-Regulation ,Cough challenge ,[SDV.IMM.IA]Life Sciences [q-bio]/Immunology/Adaptive immunology ,Vomiting ,medicine.symptom ,600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit ,psychological phenomena and processes ,Diet therapy ,NF-E2-Related Factor 2 ,Immunology ,Pungent food ,TRPV1 ,Down-Regulation ,TRPV Cation Channels ,Inflammation ,Brassica ,TRAP-1 ,Nrf2 ,03 medical and health sciences ,Severity of illness ,medicine ,Clinical Immunology − Review Article ,Humans ,business.industry ,SARS-CoV-2 ,Broccoli ,COVID-19 ,Nutrients ,Pungent foods ,Oxidative Stress ,030228 respiratory system ,nervous system ,Desensitization, Immunologic ,business ,[SDV.AEN]Life Sciences [q-bio]/Food and Nutrition ,Biomarkers - Abstract
International audience; In this article, we propose that differences in COVID-19 morbidity may be associated with transient receptor potential ankyrin 1 (TRPA1) and/or transient receptor potential vanilloid 1 (TRPV1) activation as well as desensitization. TRPA1 and TRPV1 induce inflammation and play a key role in the physiology of almost all organs. They may augment sensory or vagal nerve discharges to evoke pain and several symptoms of COVID-19, including cough, nasal obstruction, vomiting, diarrhea, and, at least partly, sudden and severe loss of smell and taste. TRPA1 can be activated by reactive oxygen species and may therefore be up-regulated in COVID-19. TRPA1 and TRPV1 channels can be activated by pungent compounds including many nuclear factor (erythroid-derived 2) (Nrf2)-interacting foods leading to channel desensitization. Interactions between Nrf2-associated nutrients and TRPA1/TRPV1 may be partly responsible for the severity of some of the COVID-19 symptoms. The regulation by Nrf2 of TRPA1/TRPV1 is still unclear, but suggested from very limited clinical evidence. In COVID-19, it is proposed that rapid desensitization of TRAP1/TRPV1 by some ingredients in foods could reduce symptom severity and provide new therapeutic strategies.
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- 2021
38. Early Trauma Is Associated with Poor Pharmacological Treatment Response in Patients with Panic Disorder
- Author
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Sang-Hyuk Lee, Ji Eun Kim, and Hyun-Ju Kim
- Subjects
medicine.medical_specialty ,Treatment response ,Panic disorder ,business.industry ,Predictors ,Confounding ,Early trauma ,Panic disorder severity scale score ,medicine.disease ,Logistic regression ,Pharmacotherapy ,Pharmacological treatment ,Psychiatry and Mental health ,Internal medicine ,medicine ,In patient ,Original Article ,business ,Biological Psychiatry - Abstract
Objective Pharmacotherapy is established as an effective method for reducing symptoms of panic disorder (PD). However, about 20–40% of PD patients are treatment-resistant. Predictors of pharmacotherapy outcomes for PD patients are needed.Methods This study included 152 PD patients to measure the clinical severities of PD symptoms and used the Early Trauma Inventory (ETI) to measure early trauma. Treatment response was defined as a 40% reduction in the total Panic Disorder Severity Scale score from baseline. We measured the treatment responses at 8 weeks and 6 months. Binary logistic regression was used to predict treatment response after controlling for confounding variables.Results Early sexual trauma alone was associated with poor treatment response at 8 weeks. However, at 6 months, the total ETI score was associated with an unfavorable treatment response.Conclusion Therefore, our study suggests that clinicians need to be aware of a history of early trauma to optimize treatment outcomes for PD patients.
- Published
- 2020
39. Modulation of Neuroinflammation by Low-Dose Radiation Therapy in an Animal Model of Alzheimer's Disease
- Author
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Hyun-Ju Kim, Hye Sun Kim, Yunjung Choi, Jin Ho Kim, Young Seok Seo, Jeongmin Yoon, Hak Jae Kim, and Eun Jeong Yang
- Subjects
Cancer Research ,Mice, Transgenic ,Pharmacology ,Proinflammatory cytokine ,Pathogenesis ,Mice ,Alzheimer Disease ,Medicine ,Dementia ,Hippocampus (mythology) ,Animals ,Radiology, Nuclear Medicine and imaging ,Cognitive Dysfunction ,Neuroinflammation ,Radiation ,Amyloid beta-Peptides ,business.industry ,Therapeutic effect ,medicine.disease ,Disease Models, Animal ,Oncology ,Low Dose Radiation Therapy ,Neuroinflammatory Diseases ,Cytokines ,Alzheimer's disease ,business - Abstract
Purpose Recently, several studies have reported that low-dose radiation therapy (RT) suppresses the release of proinflammatory cytokines in inflammatory-degenerative disorders, including Alzheimer disease (AD). AD is the most common cause of dementia, and neuroinflammation is one of the major contributing factors in AD pathogenesis. Therefore, low-dose RT may be used clinically for treating AD. However, the appropriate doses, effects, and underlying mechanisms of RT in AD have not been determined. In this study, we aimed to determine the appropriate RT dose and schedule for AD treatment and to investigate the therapeutic effects and mechanisms of low-dose RT in AD. Methods and Materials We first determined the proper dose and schedule for RT in late-stage AD using 8- to 9-month-old 5x Familial AD (5xFAD) mice, a well-known animal model of AD, by comparing the effects of a low total dose with low dose per fraction (LD-LDRT, 5 × 0.6 Gy) with those of a low moderate total dose with conventional dose per fraction (LMD-CDRT, 5 × 2 Gy). Results LD-LDRT and LMD-CDRT were found to reduce the levels of the proinflammatory cytokines CD54, IL-3, CXCL9/10, and CCL2/4 in the hippocampus of 5xFAD mice. Furthermore, increased microgliosis assessed using Iba-1 and CD68 dual immunostaining was significantly reduced by LD-LDRT and LMD-CDRT in the hippocampus of 5xFAD mice. Moreover, LD-LDRT and LMD-CDRT decreased the amyloid plaque burden in the hippocampus of 5xFAD mice and attenuated their cognitive impairment; these effects persisted for 4 to 5 weeks. Conclusions The present study showed that LD-LDRT alleviates cognitive impairments and prevents the accumulation of amyloid plaques by regulating neuroinflammation in the late stage of AD in 5xFAD mice, with an efficacy equivalent to that of LMD-CDRT. Furthermore, the findings suggest that compared with LMD-CDRT, LD-LDRT may facilitate accessible and convenient treatment in clinical trials.
- Published
- 2020
40. Preterm Twins Born to a Mother with Miliary Tuberculosis: Importance of Early Recognition and Prompt Response in Infection Control to Manage Congenital Tuberculosis Exposure in a Neonatal Intensive Care Unit
- Author
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Hyun-Jeong Do, Byung-Han Ryu, Hyun Ju Kim, Chan-Hoo Park, Eun-Hwa Baek, Da-Hye Kim, Oh-Hyun Cho, S. Hong, and Se-Eun Kim
- Subjects
0301 basic medicine ,Microbiology (medical) ,Adult ,Male ,Pediatrics ,medicine.medical_specialty ,Miliary tuberculosis ,Neonatal intensive care unit ,Health Personnel ,030106 microbiology ,Antitubercular Agents ,Twins ,Mothers ,Infant, Premature, Diseases ,Delayed diagnosis ,03 medical and health sciences ,0302 clinical medicine ,Intensive Care Units, Neonatal ,medicine ,Isoniazid ,Infection control ,Humans ,Tuberculosis ,030212 general & internal medicine ,Infection Control ,business.industry ,Tuberculin Test ,Tuberculosis, Miliary ,Infant, Newborn ,POSITIVE TUBERCULIN ,General Medicine ,Mycobacterium tuberculosis ,medicine.disease ,Tb exposure ,Infectious Disease Transmission, Vertical ,Infectious Diseases ,Treatment Outcome ,Female ,Contact Tracing ,business ,Post-Exposure Prophylaxis ,Congenital tuberculosis ,Infant, Premature ,medicine.drug - Abstract
Delayed diagnosis of congenital tuberculosis (TB) in the neonatal intensive care unit (NICU) is a serious problem in terms of infection control. Here, we report our preemptive infection control activities implemented after the diagnosis of miliary TB in a mother of preterm twins (index twins, NB1 and NB2) in the NICU. In addition, we reviewed previous case reports of congenital TB exposure in the NICU setting. Immediately after diagnosing miliary TB in the mother, the index twins were isolated before their TB diagnosis and received preemptive anti-TB medication; contact investigations were also conducted. Eventually, NB1 was diagnosed with congenital TB at 29 days of age, and NB2 showed no definite evidence of TB. Through contact investigation, 11 of the 16 exposed infants received isoniazid prophylaxis and no positive tuberculin skin test results were obtained after 3 months. One of the 31 exposed healthcare workers showed new interferon-gamma release assay conversion. Moreover, our case showed a much shorter contagious period compared to that in previous reports (8 versus 17-102 days). This suggests that a high index of suspicion and prompt measures can help prevent congenital TB outbreaks and reduce the burden of infection control activities in the NICU.
- Published
- 2020
41. Intensity-Modulated Radiotherapy-Based Reirradiation for Head and Neck Cancer: A Multi-institutional Study by Korean Radiation Oncology Group (KROG 1707)
- Author
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Chang Geol Lee, Myungsoo Kim, Yeon-Sil Kim, Jeongshim Lee, Jae Won Park, Sung-Hyun Kim, Tae Hyung Kim, and Hyun-Ju Kim
- Subjects
Male ,0301 basic medicine ,Cancer Research ,Multivariate analysis ,Intensity modulated radiotherapy ,medicine.medical_treatment ,Kaplan-Meier Estimate ,0302 clinical medicine ,Recurrence ,Reirradiation ,Aged, 80 and over ,education.field_of_study ,Medical record ,Neoplasms, Second Primary ,Middle Aged ,Prognosis ,Treatment Outcome ,Oncology ,Head and Neck Neoplasms ,030220 oncology & carcinogenesis ,Female ,Original Article ,Head and neck neoplasm ,Radiology ,Head/Neck Cancer ,Adult ,medicine.medical_specialty ,Population ,Recursive partitioning ,Re-Irradiation ,Young Adult ,03 medical and health sciences ,Republic of Korea ,Radiation oncology ,medicine ,Humans ,education ,Aged ,Retrospective Studies ,Salvage Therapy ,business.industry ,Head and neck cancer ,Chemoradiotherapy, Adjuvant ,medicine.disease ,Radiation therapy ,030104 developmental biology ,Dose Fractionation, Radiation ,Radiotherapy, Intensity-Modulated ,Neoplasm Recurrence, Local ,business ,Follow-Up Studies - Abstract
Purpose The benefits of reirradiation for head and neck cancer (HNC) have not been determined. This study evaluated the efficacy of reirradiation using intensity-modulated radiotherapy (IMRT) for recurrent or second primary HNC (RSPHNC) and identified subgroups for whom reirradiation for RSPHNC is beneficial. Materials and methods A total of 118 patients from seven Korean institutions with RSPHNC who underwent IMRT-based reirradiation between 2006 and 2015 were evaluated through retrospective review of medical records. We assessed overall survival (OS) and local control (LC) within the radiotherapy (RT) field following IMRT-based reirradiation. Additionally, the OS curve according to the recursive partitioning analysis (RPA) suggested by the Multi-Institution Reirradiation (MIRI) Collaborative was determined. Results At a median follow-up period of 18.5 months, OS at 2 years was 43.1%. In multivariate analysis, primary subsite, recurrent tumor size, interval between RT courses, and salvage surgery were associated with OS. With regard to the MIRI RPA model, the class I subgroup had a significantly higher OS than class II or III subgroups. LC at 2 years was 53.5%. Multivariate analyses revealed that both intervals between RT courses and salvage surgery were prognostic factors affecting LC. Grade 3 or more toxicity and grade 5 toxicity rates were 8.5% and 0.8%, respectively. Conclusion IMRT-based reirradiation was an effective therapeutic option for patients with RSPHNC, especially those with resectable tumors and a long interval between RT courses. Further, our patients' population validated the MIRI RPA classification by showing the difference of OS according to MIRI RPA class.
- Published
- 2020
42. Early sexual trauma is related with the tapetum in patients with panic disorder
- Author
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Chaerim Song, Minji Bang, Sanghyuk Lee, and Hyun-Ju Kim
- Subjects
medicine.medical_specialty ,Corpus callosum ,Corpus Callosum ,White matter ,03 medical and health sciences ,0302 clinical medicine ,Pharmacotherapy ,Internal medicine ,Recall bias ,medicine ,Sexual Trauma ,Humans ,Retrospective Studies ,Tapetum ,business.industry ,Panic disorder ,Panic Disorder Severity Scale ,medicine.disease ,Neuroticism ,White Matter ,030227 psychiatry ,Psychiatry and Mental health ,Clinical Psychology ,medicine.anatomical_structure ,Diffusion Tensor Imaging ,Panic Disorder ,business ,030217 neurology & neurosurgery - Abstract
Background Early trauma exposure is suggested to confer a greater risk for the development of panic disorder (PD) by altering neurodevelopmental processes. A body of studies have shown that white matter microstructures, particularly in the fronto-limbic and callosal regions, could be affected by a history of early trauma in patients with PD. The tapetum, the extended posterior part of the corpus callosum connecting the bilateral temporal lobes, has not yet been studied regarding its relationship with early trauma, especially sexual one. Methods Seventy participants with PD, sixty age- and sex-matched healthy controls were enrolled. The Early Trauma Inventory Self Report-Short Form (ETISR-SF), Neuroticism Scale, and Panic Disorder Severity Scale (PDSS) were administered. Voxel-wise statistical analysis of diffusion tensor imaging data was performed within the bilateral tapetum regions using Tract-Based Spatial Statistics (TBSS). Results In participants with PD, higher levels of sexual trauma were significantly associated with the increased fractional anisotropies (FAs) in a cluster of the right tapetum. Exploratory correlation analysis revealed that FAs in this cluster were significantly correlated with higher neuroticism and poorer treatment response after one year of pharmacotherapy. No significant correlation was found between FAs of the right tapetum cluster and the PDSS scores. Limitations The possibility of retrospective recall bias for early trauma cannot be completely ruled out. Conclusions The findings of this study suggest that the right tapetum may serve as a potential neural marker of early sexual trauma in patients with PD and contribute to personal vulnerability and poorer treatment outcome after pharmacotherapy.
- Published
- 2020
43. Impact of the timing of Helicobacter pylori eradication on the risk of development of metachronous lesions after treatment of early gastric cancer: a population-based cohort study
- Author
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Yun Jin Kim, Chan Hyuk Park, Seung In Seo, Woon Geon Shin, and Hyun-Ju Kim
- Subjects
medicine.medical_specialty ,medicine.medical_treatment ,Lower risk ,Helicobacter Infections ,Cohort Studies ,03 medical and health sciences ,0302 clinical medicine ,Interquartile range ,Risk Factors ,Stomach Neoplasms ,Gastroscopy ,medicine ,Humans ,Radiology, Nuclear Medicine and imaging ,Cumulative incidence ,biology ,Helicobacter pylori ,business.industry ,Hazard ratio ,Gastroenterology ,Cancer ,medicine.disease ,biology.organism_classification ,Surgery ,Early Gastric Cancer ,030220 oncology & carcinogenesis ,030211 gastroenterology & hepatology ,Gastrectomy ,Neoplasm Recurrence, Local ,business - Abstract
Background and Aims Helicobacter pylori eradication can reduce the risk of metachronous lesions after the treatment of early gastric cancer. We aimed to analyze the impact of the timing of H pylori eradication on metachronous recurrence. Methods Data of patients who underwent endoscopic resection or partial gastrectomy for early stage gastric cancer and received H pylori eradication therapy were obtained from the Korean National Health Insurance Service database. Patients were classified into 3 groups according to the timing of the prescription for H pylori eradication: preresection; within 1 year postresection; and >1 year postresection. Results Among 19,767 patients, 7452 and 12,315 underwent endoscopic resection and surgery, respectively. The 5-year cumulative incidence of metachronous lesions after endoscopic resection was 14.0% in the preresection group, 12.3% in the within 1 year postresection group, and 16.9% in the >1 year postresection group. Surgery was performed in 1.2% of the preresection group, 1.3% of the within 1 year postresection group, and 2.9% of the >1 year postresection group. The within 1 year postresection group had a lower risk of development of metachronous lesions than the >1 year postresection group (hazard ratio [95% confidence interval]: after endoscopic resection, 0.79 [0.65–0.95]; after surgery, 0.39 [0.28–0.53]). The risk of development of metachronous lesions did not differ between the preresection and within 1 year postresection groups. Conclusion Prescription of H pylori eradication therapy within 1 year after gastric cancer treatment reduces the risk of development of metachronous gastric neoplasms compared with a late prescription of eradication therapy in patients undergoing endoscopic resection and those undergoing surgery.
- Published
- 2020
44. Clinical significance of soluble programmed cell death ligand-1 (sPD-L1) in hepatocellular carcinoma patients treated with radiotherapy
- Author
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Kyoung Jin Kim, Hyun-Ju Kim, Jinsil Seong, and Sangjoon Park
- Subjects
Male ,0301 basic medicine ,Oncology ,medicine.medical_specialty ,Carcinoma, Hepatocellular ,Lung Neoplasms ,Immune checkpoint inhibitors ,medicine.medical_treatment ,Cell ,Enzyme-Linked Immunosorbent Assay ,B7-H1 Antigen ,03 medical and health sciences ,0302 clinical medicine ,Text mining ,Internal medicine ,mental disorders ,Biomarkers, Tumor ,medicine ,Humans ,Neoplasm Invasiveness ,Radiology, Nuclear Medicine and imaging ,Clinical significance ,Stage (cooking) ,Venous Thrombosis ,Portal Vein ,business.industry ,Liver Neoplasms ,Hematology ,Middle Aged ,medicine.disease ,Thrombosis ,Tumor Burden ,Radiation therapy ,030104 developmental biology ,medicine.anatomical_structure ,030220 oncology & carcinogenesis ,Hepatocellular carcinoma ,Female ,business - Abstract
Purpose To investigate the clinical implications of the soluble programmed cell death-ligand 1 (sPD-L1) level in hepatocellular carcinoma (HCC) patients treated with radiotherapy (RT). Materials/methods HCC patients treated with RT between June 2011 and March 2015 were prospectively recruited and sPD-L1 levels were measured using an enzyme-linked immunosorbent assay. Blood samples were obtained at the RT start, RT end, and 1-month follow-up. The associations of the sPD-L1 level with the clinical features and outcomes were analyzed. Results Fifty-three patients with HCC were included. Thirty-four patients received conventional fractionated RT with hepatic arterial infusional chemotherapy, while 19 patients received stereotactic body radiotherapy (SBRT). The initial sPD-L1 level was significantly associated with stage, tumor size, portal vein tumor thrombosis, and venous invasion. The overall-survival was significantly poorer in patients with a higher level of initial sPD-L1 (≥1.315 pg/mL). A higher level of sPD-L1 at 1 month (≥12.9 pg/mL) was significantly related to early lung metastasis. The sPD-L1 level was significantly increased after RT and the change pattern of sPD-L1 was different between two RT schemes. Conclusions The level of sPD-L1 was associated with tumor aggressiveness and outcomes, suggesting its role as a possible predictive biomarker. The increases in sPD-L1 after RT suggests that combined treatment with RT and immune checkpoint inhibitors may be a promising therapeutic strategy in HCC.
- Published
- 2018
45. Peri-implant Disease: Etiological Factors and Microbiological Approaches
- Author
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Kyoung-Hwa Kim, Yong-Moo Lee, Yang-Jo Seol, In-Chul Rhyu, Hyun-Ju Kim, and Young Ku
- Subjects
Peri-implantitis ,Peri-implant mucositis ,business.industry ,medicine ,Etiology ,Peri implant disease ,Dentistry ,medicine.disease ,business - Published
- 2018
46. Writing education instruction by genre using film
- Author
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Hyun-ju Kim
- Subjects
Literature ,Poetry ,business.industry ,media_common.quotation_subject ,Empathy ,Psychology ,business ,media_common - Published
- 2018
47. Infections of Intestinal Helminth at Two Species of Field Mice, Apodemus agrarius and A. Peninsulae, in Gangwondo and Chungcheongnam-do, Korea
- Author
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Hyun-Ju Kim, In-Wook Choi, Young-Ha Lee, Shuang Gong, Jae-Hyung Lee, and Yung Chul Park
- Subjects
0301 basic medicine ,Apodemus agrarius ,Nematoda ,Zoology ,Animals, Wild ,Brief Communication ,Intestinal helminth ,Rodent Diseases ,Mice ,03 medical and health sciences ,Chungcheongnam-do ,Gangwon-do ,Helminths ,Republic of Korea ,parasitic diseases ,Animals ,Parasite hosting ,Nippostrongylus brasiliensis ,Intestinal Diseases, Parasitic ,biology ,business.industry ,wild rodent ,030108 mycology & parasitology ,biology.organism_classification ,Hymenolepis diminuta ,Intestines ,Heterakis ,Infectious Diseases ,Nematode ,Cestoda ,Parasitology ,Livestock ,Murinae ,business - Abstract
Rodents are important reservoirs of diseases affecting people and livestock, and are major sources of parasite contamination of agricultural products. We surveyed the infection status of intestinal helminths in 2 species of field mice, Apodemus agrarius and A. peninsulae, captured in the agricultural fields of Gangwon-do and Chungcheongnam-do, Korea. Total 83 mice (57 A. agrarius and 26 A. peninsulae) were collected in 2 surveyed areas, and the intestines of each mouse were opened with scissors, and then intestinal contents were examined with microscope. Total 6 species of intestinal helminth were detected in 61 (73.5%) out of 83 mice examined. Four species of nematode, i.e., Nippostrongylus brasiliensis, Aspiculuris tetraptera, Heterakis spp. and ascarid, were found in 40 (48.2%), 14 (16.9%), 11 (13.3%) and 13 (15.7%) mice respectively. One species of cestode, Hymenolepis diminuta and 1 unidentified egg were also detected in the intestines of 14 (16.9%) and 1 (1.2%) mice, respectively. Conclusively, this study identified 5 helminth species in the gastrointestinal tracts of wild rodents captured in some areas in central and northern Korea, and N. brasiliensis was the most prevalent (dominant) species rather than zoonotic ones.
- Published
- 2018
48. A Case of Dopa-responsive Dystonia with a Mutation in the GCH1 Gene Misdiagnosed as Cerebral Palsy for 2 Years
- Author
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Kyung Yeon Lee, Hyun Ju Kim, Hui Jun Yang, and Chae Hyeon Yi
- Subjects
Dopa-Responsive Dystonia ,medicine.medical_specialty ,Levodopa ,Endocrinology ,business.industry ,Internal medicine ,Mutation (genetic algorithm) ,Medicine ,Gch1 gene ,business ,medicine.disease ,medicine.drug ,Cerebral palsy - Abstract
도파 반응성 근긴장이상증은 근긴장이상 증상이 하지부터 시작되고, 일간 변동성을 보이며, 레보도파 치료에 극적이고 지속적인 반응을 나타내는 특징을 갖는다. Segawa 병이라고도 불리는 상염색체 우성 GTP cyclohydrolase 1 결핍은 도파 반응성 근긴장이상증 중에 가장 흔하고 잘 알려진 질환이다. 하지만, 도파민의 생합성에 관련되는 다른 효소의...
- Published
- 2018
49. Pharmacokinetic and bioequivalence study of a telmisartan/S-amlodipine fixed-dose combination (CKD-828) formulation and coadministered telmisartan and S-amlodipine in healthy subjects
- Author
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Sookie La, Boram Ohk, Seung Il Cho, Bo Kyung Kim, Young-Ran Yoon, Dong Heon Yang, Woo Youl Kang, Hae Won Lee, Sook Jin Seong, Hyun-Ju Kim, and Mi-Ri Gwon
- Subjects
Adult ,Male ,safety ,Fixed-dose combination ,Cmax ,Pharmaceutical Science ,02 engineering and technology ,030204 cardiovascular system & hematology ,Pharmacology ,Bioequivalence ,telmisartan ,Benzoates ,Structure-Activity Relationship ,Young Adult ,03 medical and health sciences ,020210 optoelectronics & photonics ,0302 clinical medicine ,Pharmacokinetics ,Tandem Mass Spectrometry ,Drug Discovery ,0202 electrical engineering, electronic engineering, information engineering ,medicine ,Humans ,Original Research ,Drug Design, Development and Therapy ,Cross-Over Studies ,Dose-Response Relationship, Drug ,Molecular Structure ,business.industry ,Drug Tolerance ,Middle Aged ,Crossover study ,Healthy Volunteers ,S-amlodipine ,Confidence interval ,fixed-dose combination ,Drug Combinations ,Therapeutic Equivalency ,Tolerability ,Benzimidazoles ,Amlodipine ,Telmisartan ,business ,pharmacokinetics ,Chromatography, Liquid ,Tablets ,medicine.drug - Abstract
Woo Youl Kang,1,2,* Sook Jin Seong,1,* Boram Ohk,1,2 Mi-Ri Gwon,1,3 Bo Kyung Kim,1,2 Sookie La,4 Hyun-Ju Kim,3 Seungil Cho,1 Young-Ran Yoon,1,2 Dong Heon Yang,5 Hae Won Lee1 1Clinical Trial Center, Kyungpook National University Hospital, Daegu, Republic of Korea; 2Department of Biomedical Science, BK21 Plus KNU Bio-Medical Convergence Program for Creative Talent, Kyungpook National University Graduate School, Daegu, Republic of Korea; 3Department of Molecular Medicine, Cell and Matrix Research Institute, Kyungpook National University School of Medicine, Daegu, Republic of Korea; 4Analytical Research Division, Biocore Co Ltd, Seoul, Republic of Korea; 5Division of Cardiology, Department of Internal Medicine, Kyungpook National University School of Medicine & Hospital, Daegu, Republic of Korea *These authors contributed equally to this work Purpose: A new fixed-dose combination (FDC) formulation of telmisartan 80 mg and S-amlodipine 5 mg (CKD-828) has been developed to increase convenience (as only one tablet is required per day) and improve treatment compliance.Methods: The pharmacokinetic characteristics and tolerability of an FDC of telmisartan and S-amlodipine were compared to those after coadministration of the individual agents in this randomized, open-label, single-dose, two-way, four-period, crossover study. To analyze the telmisartan and S-amlodipine plasma concentrations using a validated liquid chromatography–tandem mass spectrometry method, serial blood samples were collected up to 48 hours post-dose for telmisartan and 144 hours post-dose for S-amlodipine, in each period.Results: Forty-eight healthy subjects were enrolled, and 43 completed the study. The mean peak plasma concentration (Cmax) and the area under the plasma concentration–time curve from time 0 to the last measurement (AUC0–t) values of telmisartan were 522.29 ng/mL and 2,475.16 ng⋅h/mL for the FDC, and 540.45 ng/mL and 2,559.57 ng⋅h/mL for the individual agents concomitantly administered, respectively. The mean Cmax and AUC0–t values of S-amlodipine were 2.71 ng/mL and 130.69 ng⋅h/mL for the FDC, and 2.74 ng/mL and 129.81 ng⋅h/mL for the individual agents concomitantly administered, respectively. The geometric mean ratio (GMR) and 90% confidence interval (CI) for the telmisartan Cmax and AUC0–t (FDC of telmisartan and S-amlodipine/concomitant administration) were 0.8509 (0.7353–0.9846) and 0.9431 (0.8698–1.0226), respectively. The GMR and 90% CI for the S-amlodipine Cmax and AUC0–t (FDC/concomitant administration) were 0.9829 (0.9143–1.0567) and 0.9632 (0.8798–1.0546), respectively. As the intrasubject variability of the Cmax for telmisartan administered individually was 42.94%, all 90% CIs of the GMRs fell within the predetermined acceptance range. Both treatments were well tolerated in this study. Conclusion: CKD-828 FDC tablets were shown to be bioequivalent to coadministration of the individual agents with the respective strength, in healthy subjects under fasting conditions. There was no significant difference in safety profile between the two treatments. Keywords: fixed-dose combination, pharmacokinetics, S-amlodipine, telmisartan, safety
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- 2018
50. The effects of a heating pad on anxiety, pain, and distress during urodynamic study in the female patients with stress urinary incontinence
- Author
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Hyun Ju Kim, Seok Ho Kang, Jong Wook Kim, Mi Mi Oh, Jun Cheon, Jeong Gu Lee, Du Geon Moon, Sung G. Kang, Young Joo Park, Jae Young Park, Jae Hyun Bae, Je Jong Kim, and Hong Seok Park
- Subjects
Adult ,Hot Temperature ,Visual Analog Scale ,Visual analogue scale ,Urinary Incontinence, Stress ,Urology ,030232 urology & nephrology ,Diastole ,Pain ,Urinary incontinence ,Anxiety ,03 medical and health sciences ,0302 clinical medicine ,Heating pad ,Female patient ,Humans ,Pain Management ,Medicine ,Aged ,030219 obstetrics & reproductive medicine ,business.industry ,Diagnostic Techniques, Urological ,Middle Aged ,Urodynamics ,Distress ,Blood pressure ,Anesthesia ,Female ,Neurology (clinical) ,medicine.symptom ,business ,Stress, Psychological - Abstract
AIMS Although generally well tolerated, a urodynamic study is an unpleasant and stressful procedure for some patients. This study evaluated the effects of a heating pad on anxiety, pain, and distress during urodynamic studies in female patients with stress urinary incontinence. METHODS A total of 74 female patients with stress urinary incontinence who underwent a urodynamic study between May 2015 and October 2015 were randomized to either the experimental group using a heating pad (n = 37) or control group (n = 37). In the experimental group, a heating pad was applied on the patient's sacrum during the urodynamic study. All patients completed the State-Trait Anxiety Inventory (20-80) before and after the procedure and assessed their degree of pain and distress after the procedure by the visual analog scale (0-10). Systolic and diastolic blood pressure and pulse rate were also checked before and after the procedure. RESULTS Demographic characteristics, mean age, procedure duration, pre and post-procedural systolic, and diastolic blood pressures, and pulse rate were statistically similar between the experimental and control groups. The mean State-Trait Anxiety Inventory was significantly lower in the experimental group than in the control group (30.9 ± 7.5 vs 42.5 ± 10.1, P
- Published
- 2018
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