1. Meta-Analysis of Gender Disparities in In-hospital Care and Outcomes in Patients with ST-Segment Elevation Myocardial Infarction
- Author
-
Robaayah Zambahari, Hyon Jae Lee, Yiping Yang, Cindy L. Grines, Daniela Tirziu, Ido Haimi, Tayyab Shah, Roy Taoutel, Andreas Baumbach, Timothy D. Henry, Sameer Mehta, Samantha Gaston, and Alexandra J. Lansky
- Subjects
Male ,medicine.medical_specialty ,medicine.medical_treatment ,030204 cardiovascular system & hematology ,03 medical and health sciences ,0302 clinical medicine ,Sex Factors ,Internal medicine ,Outcome Assessment, Health Care ,Medicine ,Humans ,030212 general & internal medicine ,Myocardial infarction ,Healthcare Disparities ,Stroke ,Aged ,Aspirin ,business.industry ,Percutaneous coronary intervention ,Odds ratio ,Middle Aged ,medicine.disease ,Confidence interval ,Hospitalization ,Meta-analysis ,Conventional PCI ,Cardiology ,ST Elevation Myocardial Infarction ,Female ,Cardiology and Cardiovascular Medicine ,business ,medicine.drug - Abstract
Gender disparities in ST-segment elevation myocardial infarction (STEMI) outcomes continue to be reported worldwide; however, the magnitude of this gap remains unknown. To evaluate gender-based discrepancies in clinical outcomes and identify the primary driving factors a global meta-analysis was performed. Studies were selected if they included all comers with STEMI, reported gender specific patient characteristics, treatments, and outcomes, according to the registered PROSPERO protocol: CRD42020161469. A total of 56 studies (705,098 patients, 31% females) were included. Females were older, had more comorbidities and received less antiplatelet therapy and primary percutaneous coronary intervention (PCI). Females experienced significantly longer delays to first medical contact (mean difference 42.5 min) and door-to-balloon time (mean difference 4.9 min). In-hospital, females had increased rates of mortality (odds ratio [OR] 1.91, 95% confidence interval [CI] 1.84 to 1.99, p
- Published
- 2020