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2 results on '"Hernandez-Jerez AF"'

1. Scientific Opinion on the state of the science on pesticide risk assessment for amphibians and reptiles

Author

EFSA Panel on Plant Protection Products and their Residues (PPR), Colin Ockleford, Paulien Adriaanse, Philippe Berny, Theodorus Brock, Sabine Duquesne, Sandro Grilli, Antonio F Hernandez‐Jerez, Susanne Hougaard Bennekou, Michael Klein, Thomas Kuhl, Ryszard Laskowski, Kyriaki Machera, Olavi Pelkonen, Silvia Pieper, Michael Stemmer, Ingvar Sundh, Ivana Teodorovic, Aaldrik Tiktak, Chris J Topping, Gerrit Wolterink, Annette Aldrich, Cecilia Berg, Manuel Ortiz‐Santaliestra, Scott Weir, Franz Streissl, Robert H Smith, and Ockleford C, Adriaanse P, Berny P, Brock T, Duquesne S, Grilli S, Hernandez-Jerez AF, Bennekou SH, Klein M, Kuhl T, Laskowski R, Machera K, Pelkonen O, Pieper S, Stemmer M, Sundh I, Teodorovic I, Tiktak A, Topping CJ, Wolterink G, Aldrich A, Berg C, Ortiz MS, Weir S, Streissl F and Smith RH

Subjects
0106 biological sciences, Environmental Risk Assessment, Veterinary (miscellaneous), Population, population, Plant Science, TP1-1185, 010501 environmental sciences, 010603 evolutionary biology, 01 natural sciences, Microbiology, Ecosystem services, protection goals, biology.animal, TX341-641, State of the science, effects, education, Environmental planning, 0105 earth and related environmental sciences, education.field_of_study, amphibians, biology, Nutrition. Foods and food supply, Chemical technology, Vertebrate, risk assessment, Research needs, pesticides, Pesticide risk assessment, reptiles, Scientific Opinion, Animal Science and Zoology, Parasitology, Business, amphibians, reptiles, risk assessment, pesticides, protection goals, effects, population, Risk assessment, Food Science
Abstract

Following a request from EFSA, the Panel on Plant Protection Products and their Residues developed an opinion on the science to support the potential development of a risk assessment scheme of plant protection products for amphibians and reptiles. The coverage of the risk to amphibians and reptiles by current risk assessments for other vertebrate groups was investigated. Available test methods and exposure models were reviewed with regard to their applicability to amphibians and reptiles. Proposals were made for specific protection goals aiming to protect important ecosystem services and taking into consideration the regulatory framework and existing protection goals for other vertebrates. Uncertainties, knowledge gaps and research needs were highlighted., This publication is linked to the following EFSA Supporting Publications article: http://onlinelibrary.wiley.com/doi/10.2903/sp.efsa.2018.EN-1357/full

Published
2018

2. Investigation into experimental toxicological properties of plant protection products having a potential link to Parkinson's disease and childhood leukaemia†

Author

EFSA Panel on Plant Protection Products and their residues (PPR), Colin Ockleford, Paulien Adriaanse, Philippe Berny, Theodorus Brock, Sabine Duquesne, Sandro Grilli, Antonio F Hernandez‐Jerez, Susanne Hougaard Bennekou, Michael Klein, Thomas Kuhl, Ryszard Laskowski, Kyriaki Machera, Olavi Pelkonen, Silvia Pieper, Rob Smith, Michael Stemmer, Ingvar Sundh, Ivana Teodorovic, Aaldrik Tiktak, Chris J Topping, Gerrit Wolterink, Karine Angeli, Ellen Fritsche, Marcel Leist, Alberto Mantovani, Pablo Menendez, Anna Price, Barbara Viviani, Arianna Chiusolo, Federica Ruffo, Andrea Terron, Ockleford, C., Adriaanse, P, Berny, P, Brock, T., Duquesne, S, Grilli, Sandro, Hernandez jerez, Af, Bennekou, Sh, Klein, M, Kuhl, T, Laskowski, R, Machera, K, Pelkonen, O, Pieper, S, Smith, R, Stemmer, M, Sundh, I, Teodorovic, I, Tiktak, A, Topping, Cj, Wolterink, G, Angeli, K, Fritsche, E, Leist, M, Mantovani, A, Menendez, P, Price, A, Viviani, B, Chiusolo, A, Ruffo, F, Terron, A, and Publica

Subjects
Environmental Risk Assessment, 0301 basic medicine, Test strategy, Epidemiology, AOP, Parkinson’s disease, childhood leukaemia, infant leukaemia, pesticides, epidemiology, Parkinson's disease, Veterinary (miscellaneous), Infant leukaemia, Context (language use), TP1-1185, Plant Science, Disease, Microbiology, Toxicology, 03 medical and health sciences, 0302 clinical medicine, Documentation, childhood leukaemia, ddc:570, Adverse Outcome Pathway, Medicine, TX341-641, Pesticides, AOP, pesticide, Nutrition. Foods and food supply, infant leukaemia, business.industry, Chemical technology, Childhood leukaemia, pesticides, 3. Good health, Scientific Opinion, 030104 developmental biology, Systematic review, Conceptual framework, Risk analysis (engineering), Parkinson’s disease, epidemiology, Animal Science and Zoology, Parasitology, Biological plausibility, business, AOP, Parkinson's disease, childhood leukaemia, infant leukaemia, pesticides, epidemiology, 030217 neurology & neurosurgery, Food Science
Abstract

In 2013, EFSA published a literature review on epidemiological studies linking exposure to pesticides and human health outcome. As a follow up, the EFSA Panel on Plant Protection Products and their residues (PPR Panel) was requested to investigate the plausible involvement of pesticide exposure as a risk factor for Parkinson's disease (PD) and childhood leukaemia (CHL). A systematic literature review on PD and CHL and mode of actions for pesticides was published by EFSA in 2016 and used as background documentation. The Panel used the Adverse Outcome Pathway (AOP) conceptual framework to define the biological plausibility in relation to epidemiological studies by means of identification of specific symptoms of the diseases as AO. The AOP combines multiple information and provides knowledge of biological pathways, highlights species differences and similarities, identifies research needs and supports regulatory decisions. In this context, the AOP approach could help in organising the available experimental knowledge to assess biological plausibility by describing the link between a molecular initiating event (MIE) and the AO through a series of biologically plausible and essential key events (KEs). As the AOP is chemically agnostic, tool chemical compounds were selected to empirically support the response and temporal concordance of the key event relationships (KERs). Three qualitative and one putative AOP were developed by the Panel using the results obtained. The Panel supports the use of the AOP framework to scientifically and transparently explore the biological plausibility of the association between pesticide exposure and human health outcomes, identify data gaps, define a tailored testing strategy and suggests an AOP's informed Integrated Approach for Testing and Assessment (IATA)., This publication is linked to the following EFSA Supporting Publications article: http://onlinelibrary.wiley.com/doi/10.2903/sp.efsa.2017.EN-1190/full

Published
2017

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