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To evaluate the clinical effects of Xiyanping injection intervention in pediatric patients with mild hand foot and mouth disease (HFMD).A total of 329 patients were stratified and block-randomized for symptomatic treatment of HFMD and assigned to one of the following groups: Western Medicine (group A, n = 103), Xiyanping injection (group B, n = 109), or Xiyanping injection and symptomatic treatment using Western Medicine (group C, n = 117). During the trial, fever, rash, ulcers of the mouth were observed among participants in each group before and after treatment, and conversion rates from mild to severe HFMD were measured.After 3-7 days' treatment, no significant differences in the conversion rates from mild to severe HFMD were observed among the three groups (P0.05). There was a significantly low number of patients with the onset time of antifebrile effect, vanished time of hand and foot rashes and cumulative time for the ulcers in the mouth vanished, among the three groups (P0.05, P0.01). The onset time of antifebrile effect of patients in groups B and C were markedly shorter compared with those in group A (P0.05, P0.01); there was no statically significant difference observed between groups B and C (P0.05). No significant differences were observed in the time for body temperature recovery among the three groups (P0.05). There were no significant differences in adverse effects among the three groups (P0.05).Xiyanping injection together with use of Western Medicine is most effective for symptomatic treatment of mild HFMD. No severe adverse reactions were observed.

Premature ovarian insufficiency (POI) affects seriously physical and mental health of the patients. Studies show that acupuncture may be promising in treating POI, yet evidence is insufficient. International patient registry, one form of observational study, is designed for evaluating effectiveness and safety of acupuncture in real-world clinical settings. We will face a series of opportunities and challenges. The opportunities are as follows: (1) Interdisciplinary cooperation can improve the effect of acupuncture for POI. (2) The protocol for acupuncture to treat POI has room for improvement. (3) The patient registry study can make up the shortcomings of randomized controlled trials. (4) The patient registry study can collect real-world data and explore responses of different populations to acupuncture and can be the foundation for the successive studies. International patient registry may face technological, ethical and financial challenges, while the established International Patient Registry Platform of Acupuncture-Moxibustion ( www.amreg.org:8082/v3 ) is actively responding to these challenges. Till now there have been more than 300 patients of POI enrolled on this platform.

In recent years, a growing number of dynamic, double-blind and randomized trials for traditional Chinese medicine (TCM) have been designed with adaptive treatment regimens. The blind envelope or current randomization and trial supply management (RTSM) system have not met this requirement. Therefore, a more efficient platform for subject randomization and medicine dispensation was required. After we had done much research on dynamic TCM treatment trials’ protocols, a new RTSM was designed and developed, which is suitable for TCM clinical trial during randomizing the groups for subject and medicine allocation in China. In a recurrent tuberculosis study of TCM, this RTSM system was involved in the management of subjects and medicines. By this system, a suit of TCM formulas or placeboes were assigned to patients based on their TCM syndrome diagnosis results by investigators at different visit points. The new RTSM system was convenient to operate, reduced operational errors, enhanced the management efficiency, and improved the data quality.

Objective To preliminarily analyze key factors influencing curative effect through clinical observations of acupoint application for “treatment of winter disease in summer” used to prevent and treat bronchial asthma in children. Methods In an observational study and prospective cohort study, we observed children in remission of asthma at three class III grade A TCM hospitals in Liaoning, Hubei, and Chengdu. Results A total of 609 children conformed to diagnostic and inclusive standards for remission of bronchial asthma. Through follow-up visits, we observed their skin reactions and the time and chance of treatment with different therapies in the three hospitals; we also compared and analyzed different drugs, acupoints, and preparations. We found that the key Chinese drugs were Bai Jie Zi (Semen Sinapis Albae) and Yian Hu Suo (Rhizoma Corydalis); the key acupoints were Feishu (BL 13), Gaohuang (BL 43), Dingchuan (EX-B1), Tiantu (CV 22), and Shanzhong (CV 17); and the best preparation was a mixture of drugs, ginger juice, and musk. Acupoint application was practiced on the hottest days of summer and the coldest days of winter for 0.5 to 2 h with the lowest rate of asthma relapse. Conclusions The present data analysis shows that the curative effect of acupoint application for “treatment of winter disease in summer” may be influenced by recipes of Chinese drugs, preparations, prescriptions of acupoints, chance, time, and skin reactions. A curative effect is the result of the comprehensive action of these factors.

Patient-reported outcome (PRO), which is directly obtained from patients, is a multidimensional measure to evaluate the health condition of a patient. The obtained data give evidence of effectiveness from patients' point of view. This article reviews the application of PRO in the study of cancer. The application of PRO is studied from aspects, such as evaluating cancer clinical trials, formulating health policies, evaluating adverse events, evaluating compliance, approving new drugs, and studying the relation between health-related quality of life and PRO.

Objective: To evaluate the effects of treatment of integrative Chinese and Western medicine (ICWM) on arterial oxygen saturation (SaO2) in patients with severe acute respiratory syndrome (SARS).Methods:The non-randomized, controlled trial was conducted on 447 SARS patients treated synchronously with western conventional treatment (WM group,n = 171) alone and ICWM (ICWM group,n = 276). The changes of the cases with normal level (≥95%) or abnormal level (0.05).Conclusion: ICWM treatment, particularly when it is used for intervention in the early stage, is beneficial for maintaining normal SaO2 in SARS patients.

The light extraction has an important effect on LED encapsulation to obtain a high efficiency. The influence of packaging structure on LED light extraction was investigated in TracePro. Four kinds of high-power LED packaging methods based on the structure and the character of flip chip were presented, flip chip on board (1 reflective-cup), flip chip to substrate (1 reflective-cup), flip chip on board (100 reflective-cups) and flip chip to substrate (100 reflective-cups). Flip chip on board was that the LED chip was directly bonded to the aluminum substrate, flip chip to substrate was the LED chip bonded to the Si-Substrate before bonded to the aluminum. Two different structures of aluminum substrate were analyzed, 1 substrate with only 1 reflective cup and 1 substrate with 100 reflective cups. The final result shows that the luminous efficiency of flip chip on board (100 reflective-cups) is 0.03% higher than flip chip to substrate (100 reflective-cups); luminous efficiency of flip chip on board (1 reflective-cup1) is 0.04% lower than flip chip to substrate(1 reflective-cup). Luminous efficiency of flip chip on board (100 reflective-cups) is 10% higher than flip chip on board(1 reflective-cups); luminous efficiency of flip chip to substrate (100 reflective-cups) is 6.3% higher than flip chip to substrate(1 reflective-cup).

In fault diagnosis and medical diagnosis fields, often there is more than one fault or disease that occur together. In order to obtain the factors that cause a single fault to change to multi-faults, the standard rough set based methods should be rebuilt. In this paper, we propose a decernibilty matrix based algorithm with which the cause of every single fault to change to multi-faults can be revealed. Additionally, we propose another rough set based algorithm to induce the common causes of all the single faults to change to their corresponding multi-faults, which is a process of knowledge discovery in rule base, i.e., not the usual database. Inducing more abstract rules in knowledge base is a very challenging problem that has not been resolved well.

Because of the amount of missing values in our SARS data set is very large, to fill in them wholly with the existing methods is impossible or the results of being filled in are not reliable. Only taking two attributes into account can avoid using the large amount of missing values, which is the feature of rough set that other machine learning method cannot hold. In this paper, we induced some rules based on rough set from the SARS data set that have not been detected by medical experts in clinic practice.

Objective To evaluate the efficacy and safety of Xinfeng capsule in patients suffering rheumatoid arthritis (RA). Methods A multi-center parallel-group designed, double-blind, randomized, controlled trial was conducted. Totally 304 RA patients were assigned to two groups: one group was administered Xinfeng capsule (XFC) plus the placebo of leflunomide and the other given leflunomide (LEF) plus the placebo of XFC for twelve weeks. The clinical and laboratory parameters were compared at baseline and fourth, eighth, and twelfth weeks. Results After twelve-week treatment, patients in two groups all showed some trend of effectiveness when compared in terms of American Rheumatism Association (ACR) recommended 20%, 50%, 70% improvement criteria, but it was insignificant. The validity in ameliorate modified disease activity score (DAS28) and laboratory indexes as erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), rheumatoid factor (RF) were also found no difference. The score of health assessment questionnaire (HAQ), self-rating anxiety scale (SAS), self-rating depression scale (SDS) and quality of life questionnaire with rheumatoid arthritis (RAQOL) both lower than the first week and the changes showed no difference. However, the score of SDS dropped more in XFC group than in the other. A total of 147 adverse reaction cases were reported, which shows no difference between the two groups. The most common adverse reactions were hepatic impairment, anemia, leukocytopenia, epigastric discomfort and phalacrosis. Conclusion XFC demonstrated better improvement in the scores of SDS and compared with those of LEF group.

ObjectiveWe sought to test the hypothesis that Polygenic Risk Scores (PRSs) have strong capacity to discriminate cases of ankylosing spondylitis (AS) from healthy controls and individuals in the community with chronic back pain.MethodsPRSs were developed and validated in individuals of European and East Asian ethnicity, using data from genome-wide association studies in 15 585 AS cases and 20 452 controls. The discriminatory values of PRSs in these populations were compared with other widely used diagnostic tests, including C-reactive protein (CRP), HLA-B27 and sacroiliac MRI.ResultsIn people of European descent, PRS had high discriminatory capacity with area under the curve (AUC) in receiver operator characteristic analysis of 0.924. This was significantly better than for HLA-B27 testing alone (AUC=0.869), MRI (AUC=0.885) or C-reactive protein (AUC=0.700). PRS developed and validated in individuals of East Asian descent performed similarly (AUC=0.948). Assuming a prior probability of AS of 10% such as in patients with chronic back pain under 45 years of age, compared with HLA-B27 testing alone, PRS provides higher positive values for 35% of patients and negative predictive values for 67.5% of patients. For PRS, in people of European descent, the maximum positive predictive value was 78.2% and negative predictive value was 100%, whereas for HLA-B27, these values were 51.9% and 97.9%, respectively.ConclusionsPRS have higher discriminatory capacity for AS than CRP, sacroiliac MRI or HLA-B27 status alone. For optimal performance, PRS should be developed for use in the specific ethnic groups to which they are to be applied.