1. Automated detection of early-stage ROP using a deep convolutional neural network
- Author
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Wei-Chi Wu, Yo-Ping Huang, Michael F. Chiang, Chi Chun Lai, Robison Vernon Paul Chan, Haobijam Basanta, John P. Campbell, Yoko Fukushima, Eugene Yu Chuan Kang, Shunji Kusaka, Kuan-Jen Chen, and Yih Shiou Hwang
- Subjects
Male ,congenital, hereditary, and neonatal diseases and abnormalities ,medicine.medical_specialty ,genetic structures ,Gestational Age ,02 engineering and technology ,Sensitivity and Specificity ,Convolutional neural network ,Article ,03 medical and health sciences ,Cellular and Molecular Neuroscience ,0302 clinical medicine ,Ophthalmology ,Image Processing, Computer-Assisted ,0202 electrical engineering, electronic engineering, information engineering ,Birth Weight ,Humans ,Medicine ,Retinopathy of Prematurity ,Diagnosis, Computer-Assisted ,Reference standards ,Retrospective Studies ,Deep cnn ,Receiver operating characteristic ,business.industry ,Infant, Newborn ,Retinopathy of prematurity ,Infant, Low Birth Weight ,medicine.disease ,eye diseases ,Sensory Systems ,Cross-Sectional Studies ,ROC Curve ,030221 ophthalmology & optometry ,Female ,020201 artificial intelligence & image processing ,sense organs ,Neural Networks, Computer ,business ,Algorithms ,Infant, Premature - Abstract
Background/AimTo automatically detect and classify the early stages of retinopathy of prematurity (ROP) using a deep convolutional neural network (CNN).MethodsThis retrospective cross-sectional study was conducted in a referral medical centre in Taiwan. Only premature infants with no ROP, stage 1 ROP or stage 2 ROP were enrolled. Overall, 11 372 retinal fundus images were compiled and split into 10 235 images (90%) for training, 1137 (10%) for validation and 244 for testing. A deep CNN was implemented to classify images according to the ROP stage. Data were collected from December 17, 2013 to May 24, 2019 and analysed from December 2018 to January 2020. The metrics of sensitivity, specificity and area under the receiver operating characteristic curve were adopted to evaluate the performance of the algorithm relative to the reference standard diagnosis.ResultsThe model was trained using fivefold cross-validation, yielding an average accuracy of 99.93%±0.03 during training and 92.23%±1.39 during testing. The sensitivity and specificity scores of the model were 96.14%±0.87 and 95.95%±0.48, 91.82%±2.03 and 94.50%±0.71, and 89.81%±1.82 and 98.99%±0.40 when predicting no ROP versus ROP, stage 1 ROP versus no ROP and stage 2 ROP, and stage 2 ROP versus no ROP and stage 1 ROP, respectively.ConclusionsThe proposed system can accurately differentiate among ROP early stages and has the potential to help ophthalmologists classify ROP at an early stage.
- Published
- 2020
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