1. Multi-Facial, Non-Peptidic α-Helix Mimetics
- Author
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Maryanna E. Lanning and Steven Fletcher
- Subjects
p53 ,Review ,Computational biology ,Biology ,computer.software_genre ,General Biochemistry, Genetics and Molecular Biology ,HMD2 ,Protein–protein interaction ,Text mining ,cancer ,Bcl-2 ,Bim ,α-helix mimetic ,lcsh:QH301-705.5 ,proteomimetic ,General Immunology and Microbiology ,business.industry ,Bak ,protein–protein interaction ,amphipathic ,lcsh:Biology (General) ,Helix ,Data mining ,General Agricultural and Biological Sciences ,business ,computer - Abstract
α-Helices often recognize their target proteins at protein-protein interfaces through more than one recognition face. This review describes the state-of-the-art in the design of non-peptidic α-helix mimetics that reproduce functionality from multiple faces of an α-helix.
- Published
- 2015
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