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Epoxy acrylate (EA) resin, due to its thermo-mechanical properties, performs excellent shaper memory properties. 3D printing opens new opportunities to fabricated shape memory polymer (SMP), which contributed to a rising variety of applications, also requires 3D-printable capability with more advanced shape-memory function and mechanical performance of the material. In this paper, a new strategy was developed to fabricate high strain EA-based SMP through digital light processing (DLP) 3D printing, which took advantage of free radical copolymerization of epoxy acrylate-based oligomer and monomers. The 3D-printed SMP showed high strain at break (up to 90%), thermal stability, as well as excellent shape memory performance. In addition, the shape memory-based self-driven electronics was fabricated by combining shape memory polymer with light-absorbing and conductive ink. The device could change its configuration in response to light and temperature, which has great potential application for soft robotics, flexible electronics, and intelligent control devices.

With the accelerated development of the global economy, the scale of UHV (Ultra High Voltage) large-capacity transmission lines has increased dramatically. Nevertheless, existing transmission line inspection methods rely on human inspectors detecting abnormal facilities from ground level or helicopters. Those methods not only require extremely high labor and equipment costs, but also are time-consuming. In this paper, a thin object 3D reconstruction method is proposed for the extraction of 3D structures of power lines from sequential oblique UAV images. The proposed method recovers the 3D structure of the power lines from three sequential images that depict the structure of power lines in 2D. Proposed method was tested in a typical transmission line corridor and the reconstructed results show the effectiveness of the proposed method.

In order to estimate the soil water content of the plough layer using the surface soil spectrum, based on the water content data and hyperspectral data of 85 surface layers and ploughed soil samples in Jiyang County, Shandong Province, 10 transformation methods such as square root are used. The spectral reflectance of the topsoil is transformed, and the estimation factor is selected according to the principle of maximal correlation. Then, according to the correlation between the water content of the surface layer and the plough layer, two indirect estimation models are constructed.Six kinds of modeling methods such as multiple linear regression, partial least squares regression and support vector machine were used to estimate the soil water content of the cultivated layer, and the effectiveness of the two indirect estimation models was compared and analyzed. The results show that the decision coefficient R2 of the first mode is 0.8138, the average relative error is 9.6061% and the decision coefficient R2 of the second mode is 0.8115, the average relative error is 12.1403%. The researches show that it is feasible and effective to estimate the soil water content of the plough layer by using the surface soil spectrum. It provides a new idea for the rapid diagnosis of soil moisture and nutrients by using optical satellite remote sensing technology.

We report the quasi-periodic whistler-mode waves corresponding to electron temperature anisotropy T⊥/T// < 1 at the center of a macroscale magnetic hole (MH) near the Earth's magnetopause observed by the Magnetospheric Multiscale mission. A significant ultra-low frequency (ULF) wave of background magnetic field was observed in this MH. The ULF wave dramatically exacerbates the evolution of MH and the formation of the donut-shaped electron pitch angle distribution (PAD) in the macroscale MH. When the whistler-mode waves were generated, they are consistent with troughs of the ULF wave and density increases, which is also related to the butterfly type PAD at those moments. The analysis of dispersion relation and cyclotron resonance condition indicate that whistler-mode waves were mainly generated by the butterfly type PAD of electrons. Our results provides new insights into one possible excitation mechanism of whistler-mode wave.

Purpose Recent evidence suggests that there is a correlation between the micro- and macrovascular complications of diabetes mellitus. The aim of this study is to investigate the molecular mechanisms by which diabetes promotes the development of microvascular disease (diabetic retinopathy [DR]) through characterization of the effects of hyperglycemia in the retina of mouse models of diabetic atherosclerosis. Methods Hyperglycemia was induced in apolipoprotein E-deficient (ApoE-/-) mice, a model of accelerated atherosclerosis, either through streptozotocin (STZ) injection or introduction of the Ins2Akita mutation (ApoE-/-Ins2+/Akita). Another subset of ApoE-/- mice was supplemented with glucosamine (GlcN). To attenuate atherosclerosis, subsets of mice from each experimental group were treated with the chemical chaperone, 4-phenylbutyric acid (4PBA). Eyes from 15-week-old mice were either trypsin digested and stained with periodic acid-Schiff (PAS) or frozen for cryostat sectioning and immunostained for endoplasmic reticulum (ER) stress markers, including C/EBP homologous protein (CHOP) and 78-kDa glucose-regulated protein (GRP78). PAS-stained retinal flatmounts were analyzed for microvessel density, acellular capillaries, and pericyte ghosts. Results Features of DR, including pericyte ghosts and reduced microvessel density, were observed in hyperglycemic and GlcN-supplemented mice. Treatment with 4PBA reduced ER stress in the retinal periphery and attenuated DR in the experimental groups. Conclusions Mouse models of diabetic atherosclerosis show characteristic pathologies of DR that correlate with atherosclerosis. The increased magnitude of these changes and responses to 4PBA in the peripheral retina suggest that future studies should be aimed at assessing regional differences in mechanisms of ER stress-related pathways in these mouse models.

BackgroundThe tourniquet is a common medical instrument used in total knee arthroplasty (TKA). However, there has always been a debate about the use of a tourniquet and there is no published meta-analysis to study the effects of a tourniquet on blood loss in primary TKA for patients with osteoarthritis.MethodsWe performed a literature review on high-quality clinical studies to determine the effects of using a tourniquet or not on blood loss in cemented TKA. PubMed, Web of Science, MEDLINE, Embase, and the Cochrane Library were searched up to November 2018 for relevant randomized controlled trials (RCTs). We conducted a meta-analysis following the guidelines of the Cochrane Reviewer’s Handbook. We used the Cochrane Collaboration’s tool for assessing the risk of bias of each trial. The statistical analysis was performed with Review Manager statistical software (version 5.3).ResultsEleven RCTs involving 541 patients (541 knees) were included in this meta-analysis. There were 271 patients (271 knees) in the tourniquet group and 270 patients (270 knees) in the no tourniquet group. The results showed that using a tourniquet significantly decreased intraoperative blood loss (P P P P > 0.05), total blood loss (P > 0.05), the rate of transfusion (P > 0.05), and of deep vein thrombosis (DVT) (P > 0.05) in TKA.ConclusionsUsing a tourniquet can significantly decrease intraoperative blood loss, calculated blood loss, and operation time but does not significantly decrease the rate of transfusion or the rate of DVT in TKA. More research is needed to determine if there are fewer complications in TKA without the use of tourniquets.

Introduction Boards of nursing (BONs) use websites to connect with the public. Content and design of BON websites have a direct impact on the efficacy of bi-directional communication. Aim To evaluate BON websites and provide objective feedback. Methods Fifty-five BON websites were evaluated using a tool based on the Website Criteria Checklist and Points System developed by the West Virginia Legislative Auditor (2014). This evaluation focused on the websites’ user-friendliness as well as BONs’ transparency. Standard descriptive analyses were performed. Results All websites scored well in providing licensure information and public complaint forms. Few websites offered social media links and audio features. Overall, BON websites offer clear, comprehensive, and transparent information to their users.

Microwave interferometry is an effective and reliable way to measure line integrated plasma electron density. An extremely low noise heterodyne interferometer has been developed for routine operation in Sino-UNIted Spherical Tokamak (SUNIST) and acts as the prototype design of a microwave inteferometer for Experimental Advanced Superconducting Tokamak (EAST) in the near future. The system has been designed with optimum frequency deduced from detailed calculation in real geometry and discharge parameters. In contrary to traditional heterodyne interferometers, the application of a single sideband modulator (SSBM) eliminates the necessity of the second millimeter wave (MMW) oscillator, which averts the intermediate frequency (IF) stability problem aroused by the two high frequency oscillators in the traditional heterodyne configuration. A pair of specially designed spot focusing antenna is also applied to boost the signal to noise ratio (SNR), whose near field scan data displays excellent focusability. The bench test data and plasma electron density measurement results from SUNIST discharges consistently show excellent performance of the interferometer, which is expected to be suitable for steady-state plasma experiments due to the high stability.

Accumulating evidence suggests that expression of aromatase, the enzyme responsible for the conversion of androgens to estrogens, is transiently upregulated in rat stroke models. It was further suggested that increased aromatase expression is linked to neuroinflammation and that it is neuroprotective in females. Our goal was to investigate aromatase upregulation in male rats subjected to experimental stroke in relationship to neuroinflammation, infarct and response to treatment with different putative neuroprotective agents. Intact male rats were subjected to transient (90min) middle cerebral artery occlusion (MCAO) and administered selfotel (N-methyl-d-aspartic acid (NMDA) receptor competitive antagonist), TPEN (a zinc chelator), a combination of the two drugs or vehicle, injected immediately after reperfusion. Animals were killed 14days after MCAO and consecutive brain sections used to measure aromatase expression, cerebral infarct volume and neuroinflammation. Quantitative immunohistochemistry (IHC) demonstrated increased brain aromatase expression in the peri-infarct area relative to contralesional area, which was partially abrogated by neuroprotective agents. There was no correlation between aromatase expression in the peri-infarct zone and infarct volume, which was reduced by neuroprotective agents. Microglial activation, measured by quantitative autoradiography, was positively correlated with infarct and inversely correlated with aromatase expression in the peri-infarct zone. Our findings indicate that focal ischemia upregulates brain aromatase in the male rat brain at 14days post surgery, which is within the time frame documented in females. However, the lack of negative correlation between aromatase expression and infarct volume and lack of positive correlation between microgliosis and aromatase do not support a major role for aromatase as a mediator of neuroprotection or a causal relationship between microglial activation and increased aromatase expression in male focal ischemia.

Introduction: Objective to summarize the work flow list during epidemic period, and to discuss and summarize the process management and prevention and control methods of each link in Tumor area during epidemic period of novel coronavirus pneumonia (NCP), in order to achieve the orderly completion of radiotherapy and chemotherapy for tumor patients, and prevent a tumor patient from contracting novel coronavirus pneumonia Methods: According to the characteristics of the transmission of NCP and the relevant documents of the National Health Commission, the list of management work was carded out, to establish various prevention and control processes in tumor wards, control key population, establish correct infection control measures, scientifically protect key personnel and effectively manage protective materials Results: During the epidemic period of NCP, the tumor inpatients could complete the radiotherapy and chemotherapy in time and effectively, and the infection of NCP was avoided The ability and knowledge of prevention and control of hospital infection of new pneumonia were improved [Formula presented] Conclusion: The nursing managers adopt and implement correct measures to prevent and control NCP infection through the management work list system, which can effectively ensure the safety of tumor patients and the occupational safety of medical workers The purpose of this study is to provide practical experience for the establishment of infectious emergency nursing management system in common disease areas Keywords: List of management, Oncology ward, coronavirus pneumonia

Background:Behcet’s disease (BD) is a chronic and relapsing vasculitis, in which major vessel involvement is a main cause of mortality and morbidity. The therapeutic arsenal is mainly composed of classical immunosuppressants. However, when faced with resistance to these drugs, no alternative therapeutic strategy is currently recommended.Objectives:To assess the efficacy and safety of interleukin 6 receptor inhibitor tocilizumab (TCZ) in refractory arterial involvement of BD in a real-life observational setting.Methods:10 patients were enrolled in our center between 2014 and 2019. All patients met the international criteria for BD and had severe arterial involvement evaluated by echocardiography, angio-Computerized Tomography scan and vascular Doppler. The diagnosis of refractory arterio-BD was based on objective vascular symptoms not explained by any other known disease and non-response to conventional immunosuppressants combined with glucocorticoids therapy. All patients underwent TCZ infusions at 8mg/kg every 4 weeks. Concomitant therapy with immunosuppressants and glucocorticoids was continued. Clinical and imaging findings were assessed before and after TCZ therapy. All adverse events were recorded during follow-up.Results:All the patients were males, with a mean age of 44.3±10.5 years in this study. The mean age at presentation of arterial involvement was 40.8±9.2 years old. The patterns of arterial involvement were aneurysm (n=9), stenosis (n=3) and aortic valve lesion (n=2). After a mean follow-up of 26.8±7.2 months, TCZ yielded rapid and maintained clinical improvement in 9 patients, with complete remission in 6 of them and partial response in 3 of them. Discontinuation of TCZ treatment due to relapse occurred in one case as the enlargement of abdominal aortic aneurysm. The mean glucocorticoid dosage was tapered from 54.5±20.6mg/d to 8.3±3.6mg/d (pConclusion:TCZ was a safe and effective therapeutic option for refractory arterial involvement of BD, with a favorable steroid-sparing effect.References:[1]G Hatemi, R Christensen, D Bang, et al. 2018 update of the EULAR recommendations for the management of Behçet’s syndrome. Ann Rheum Dis. 2018;77(6):808-818.[2]Y Ozguler, P Leccese, R Christensen, et al. Management of major organ involvement of Behcet’s syndrome: a systematic review for update of the EULAR recommendations. Rheumatology (Oxford). 2018;57(12):2200-2212.[3]M Akiyama, Y Kaneko, T Takeuchi. Effectiveness of tocilizumab in Behcet’s disease: A systematic literature review. Semin Arthritis Rheum. 2020;50(4):797-804.Table 1.Tocilizumab therapy in ten cases of refractory arterio-BDPatientAge, yearDisease duration, monthsClinical features*Arterial lesionsPrevious therapyResponse at week 24134228O, G, P, S, IStenosis of CA/ SMA/RA/SCA, aortic valve prolapsePred/CYC/MMFCR22024O, SDissecting aneurysm of AA (Debakey I)Pred/MMFPR367276O, G, P, S, Athoracoabdominal aortic aneurysmPred/CYC/TACCR46775O, S, UStenosis of LAD/LCX/RCAPred /CYCCR55080O, G, AAbdominal and coronary aortic aneurysmsPred /CYCRelapse64826O, GAortic insufficiencyPred /CYCPR726147O, P, S, VIliac artery aneurysmPred /MMFCR849466O, S, VThoracoabdominal and coronary aortic aneurysmsPred /CYC/AZACR927181O, P, SPseudoaneurysm of CCAPred /CYCPR10Male/55354O, P, SAbdominal aneurysm, stenosis of LAD/LCX/RCAPred /CYC/AZACR*O: oral ulcer; G: genital ulcer; P: pathergy test; S: skin lesions; I: intestinal ulcer; A: arthritis; U: uveitis; V: venous thrombosisFigure 1.Changes from baseline in BSAS, BDCAF, ESR, CRP and steroid daily dose at 24 weeksDisclosure of Interests:None declared

Introduction Data on prophylactic cranial irradiation (PCI) after complete resection of SCLC are limited. The purpose of this study was to investigate the impact of PCI in this population. Methods We retrospectively identified completely resected SCLC at the Shanghai Chest Hospital between January 2006 and January 2014. Results A total of 349 patients (115 patients who received PCI [the PCI-treated cohort] and 234 patients who did not [the non–PCI-treated cohort]) were included in the study. The results demonstrated that the PCI-treated cohort had longer overall survival than the non–PCI-treated cohort among patients with pathologic stage (p-stage) II (hazard ratio [HR] = 0.54, 95% confidence interval [CI]: 0.30–0.99, p = 0.047) and p-stage III (HR = 0.54, 95% CI: 0.34–0.86, p = 0.009) disease. Among patients with p-stage III disease, there was a significantly higher risk for cerebral recurrence from the time of diagnosis in the non–PCI-treated cohort ( p = 0.018). With regard to patients with p-stage I disease, neither overall survival benefit (HR = 1.61, 95% CI: 0.68–3.83, p = 0.282) nor risk for cerebral recurrence ( p = 0.389) was significant between the PCI-treated and non–PCI-treated cohorts. Conclusions The data presented in the current study support using PCI in patients with p-stage II/III disease but not in patients with p-stage I disease. A relatively lower risk for brain metastases in p-stage I patients might explain the inferior efficacy of PCI in this population.

This retrospective study was to investigate whether radiomics feature come from radiotherapy treatment planning CT can predict prognosis in locally advanced rectal cancer patients treated with neoadjuvant chemoradiation followed by surgery. Four-hundred-eleven locally advanced rectal cancer patients which were treated with neoadjuvant chemoradiation enrolled in this study. All patients’ radiotherapy treatment planning CTs were collected. Tumor was delineated on these CTs by physicians. An in-house radiomics software was used to calculate 271 radiomics features. The results of test-retest and contour-recontour studies were used to filter stable radiomics (Spearman correlation coefficient > 0.7). Twenty-one radiomics features were final enrolled. The performance of prediction model with the radiomics or clinical features were calculated. The clinical outcomes include local control, distant control, disease-free survival (DFS) and overall survival (OS). Model performance C-index was evaluated by C-index. Patients are divided into two groups by cluster results. The results of chi-square test revealed that the radiomics feature cluster is independent of clinical features. Patients have significant differences in OS (p = 0.032, log rank test) for these two groups. By supervised modeling, radiomics features can improve the prediction power of OS from 0.672 [0.617 0.728] with clinical features only to 0.730 [0.658 0.801]. In conclusion, the radiomics features from radiotherapy CT can potentially predict OS for locally advanced rectal cancer patients with neoadjuvant chemoradiation treatment.

Objective: The clinical course of unconsciousness after traumatic brain injury (TBI) is commonly unpredictable and it remains a challenge with limited therapeutic options. The aim of this study was to evaluate the early changes in serum sex hormone levels after severe TBI (sTBI) and the use of these hormones to predict recovery from unconsciousness with regard to sex. Methods: We performed a retrospective study including patients with sTBI. A statistical of analysis of serum sex hormone levels and recovery of consciousness at 6 months was made to identify the effective prognostic indicators. Results: Fifty-five male patients gained recovery of consciousness, and 37 did not. Of the female patients, 22 out of 32 patients regained consciousness. Male patients (n = 92) with sTBI, compared with healthy subjects (n = 60), had significantly lower levels of follicular stimulating hormone (FSH), testosterone and progesterone and higher levels of prolactin. Female patients (n = 32) with sTBI, compared with controls (n = 60), had significantly lower levels of estradiol, progesterone, and testosterone and significantly higher levels of FSH and prolactin. Testosterone significantly predicted consciousness recovery in male patients. Normal or elevated testosterone levels in the serum were associated with a reduced risk of the unconscious state in male patients with sTBI. For women patients with sTBI, sex hormone levels did not contribute to the prediction of consciousness recovery. Conclusion: These findings indicate that TBI differentially affects the levels of sex-steroid hormones in men and women patients. Plasma levels of testosterone could be a good candidate blood marker to predict recovery from unconsciousness after sTBI for male patients.

The objective of this study was to determine bile acid metabolism and its association with fetal pig death in pregnant gilts. A total of 430 gilts/sows with similar genetic background (Landrace×Yorkshire) were included in this study, 407 of them from parity 1 to 9 were selected to evaluate the critical time of fetal death, 12 gilts implanted with cephalic vein catheters were used to determine the relationship of bile acid metabolism with fetal death, and additional 11 pregnant gilts at gestation day 60 (G60) and 90 (G90), respectively, were sacrificed at 8h postprandial for determination of mechanism accounting for disrupted bile acid homeostasis and fetal death. Pregnant gilts had raised serum total bile acids (TBA), which reached peak levels (7.10–67.00 μmol/L) at G90, and was ~1–8 time that at G60 (4.10–20.00 μmol/L). Moreover, fetal death predominantly occurred during late pregnancy, with 70.67% of dead fetuses observed from G76 to farrowing. Fetal mortality was positively correlated with the increasing of TBA ratio of G90/G60, and significant difference in fetal survival appeared between the ratio “

A five-channel microwave interferometer with high temporal resolution and high phase resolution has been developed for measuring electron density profiles and fluctuations on the Sino-UNIted Spherical Tokamak. A correction algorithm, based on the low signal amplitude detection, is proposed to eliminate the fringe jump errors. The correction algorithm achieves an accuracy of 92%. The density profile is reconstructed through the Park-matrix method, with the geometry of magnetic surfaces calculated by the equilibrium fitting. The reconstructed density profiles for discharges with supersonic molecular beam injection are in good agreement with the results of another 94 GHz single-channel horizontal interferometer and the Langmuir probes. The temporal resolution of the system is 0.5 µs and the line-integrated electron density resolution is 1 × 1015 m−2, which benefits from the single sideband modulation technique. Therefore, the multichannel interferometer system is capable of studying the details of the high-frequency (up to 200 kHz) density fluctuation such as that in the minor disruption event.

// Panpan Hu 1, 2 , Jiazhou Wang 1, 2 , Haoyu Zhong 1, 2 , Zhen Zhou 1, 2 , Lijun Shen 1, 2 , Weigang Hu 1, 2 , Zhen Zhang 1, 2 1 Department of Radiotherapy, Fudan University Shanghai Cancer Center, Shanghai, China 2 Department of Oncology, Fudan University Shanghai Medical College, Shanghai, China Correspondence to: Zhen Zhang, email: zhenzhang6@gmail.com Keywords: radiomics, rectal cancer, reproducibility, textural features Received: July 26, 2016 Accepted: September 16, 2016 Published: September 22, 2016 ABSTRACT Purpose: To evaluate the reproducibility of radiomics features by repeating computed tomographic (CT) scans in rectal cancer. To choose stable radiomics features for rectal cancer. Results: Volume normalized features are much more reproducible than unnormalized features. The average value of all slices is the most reproducible feature type in rectal cancer. Different filters have little effect for the reproducibility of radiomics features. For the average type features, 496 out of 775 features showed high reproducibility (ICC ≥ 0.8), 225 out of 775 features showed medium reproducibility (0.8 > ICC ≥ 0.5) and 54 out of 775 features showed low reproducibility (ICC < 0.5). Methods: 40 rectal cancer patients with stage II were enrolled in this study, each of whom underwent two CT scans within average 8.7 days. 775 radiomics features were defined in this study. For each features, five different values (value from the largest slice, maximum value, minimum value, average value of all slices and value from superposed intermediate matrix) were extracted. Meanwhile a LOG filter with different parameters was applied to these images to find stable filter value. Concordance correlation coefficients (CCC) and inter-class correlation coefficients (ICC) of two CT scans were calculated to assess the reproducibility, based on original features and volume normalized features. Conclusions: Features are recommended to be normalized to volume in radiomics analysis. The average type radiomics features are the most stable features in rectal cancer. Further analysis of these features of rectal cancer can be warranted for treatment monitoring and prognosis prediction.

SummaryBackground and Aim Hepatocellular carcinoma (HCC) recurrence after orthotopic liver transplantation (OLT) continues to confound transplant surgeons and physicians. There are no effective methods to predict the patients at risk for recurrence so far although many studies have sought meaningful biomarkers. The ImmuKnow (IMK) assay is an immune cell function assay that detects cell-mediated immunity in an immunosuppressed population, mainly measuring peripheral blood CD4+ adenosine triphosphate (ATP) release. The aim of this study was to assess the relationship between cellular immune function measured by the ImmuKnow assay and HCC recurrence post-OLT. Methods A total of 76 HCC cases underwent Donation after Cardiac Death (DCD) liver transplant, which confirmed hepatocellular carcinoma by histology postoperatively. The ImmuKnow assay was prospectively performed in these cases at a range of 6–36 months post-OLT. Every test was repeated 1 week later, obtaining the average value for every patient. In addition, every case had liver imaging findings at approximately the exam time. Results Fifteen cases with liver imaging findings showed HCC recurrence (19.7%) post-OLT, and the average ImmuKnow assay in these patients was 190 ± 48 ng/ml, which was less (p

Introduction Nurses with criminal convictions accounted for approximately 10% of the disciplinary actions taken by state boards of nursing (BONs) between 2003 and 2013. The purpose of this study was to better understand the types of crimes for which nurses are convicted and what actions BONs are taking to protect the public. Methods The records of nurses and nurse applicants who received disciplinary actions in the years 2012 and 2013 for a criminal conviction were extracted from the Nursys® database. Information on demographic and licensure characteristics, the type of crime committed, and the actions issued by the BON were coded and analyzed. Results 4,260 nurses and 559 nurse applicants received a board action in 2012 and 2013 due to a criminal conviction. Male nurses and licensed practical nurse/vocational nurses were overrepresented as compared to their proportion in the national nursing workforce. Driving under the influence, violation of the Controlled Substances Act, and theft were the most common crimes; probation and suspension of license were the most common BON actions. Board actions for egregious crimes and crimes involving patients were more severe. Among all nurses and applicants in this group, 18% failed to disclose a previous criminal conviction. Conclusion Overall, the vast majority of nurses are safe practitioners. The majority of crimes reported to BONs are not patient-related. This study provides evidence that BONs diligently address criminal convictions and evaluate whether the conviction is an indication that the individual is capable of practicing nursing safely.

A novel single-phase full-color phosphor Ca 9 Bi(PO 4 ) 7 :Dy 3+ was synthesized by a high-temperature solid-state reaction. X-ray powder diffraction analysis confirmed the phase formation of Ca 9 Bi(PO 4 ) 7 :Dy 3+ material. The photoluminescence (PL) excitation and emission spectra and the concentration dependence of the emission intensity of the phosphor were investigated. The results show that the phosphor could be efficiently excited by near-UV (NUV) light (340–440 nm), exhibiting blue (487 nm) and yellow (577 nm) emissions corresponding to the 4 F 9/2 → 6 H 15/2 and 4 F 9/2 → 6 H 13/2 transitions, respectively. The luminescence intensity of Ca 9 Bi 1− x (PO 4 ) 7 : x Dy 3+ phosphor first increased and then decreased with increasing Dy 3+ concentration and reached the maximum value at x = 0.20. The effect of Mg 2+ co-doping concentration on the PL intensity of the as-prepared samples was also investigated. The calculated color coordinates lie in the white region. Therefore, the obtained results suggest that the prepared phosphors have great potential for use as single-phase full-color phosphors for NUV white-light-emitting diodes.

This paper discusses the problem that the output efficiency of photovoltaic module decreases with the temperature rise of its environment. Combining photovoltaic power generation and photothermal technology, a new model of solar photovoltaic photothermal integrated louver curtain wall is proposed, which can not only have photovoltaic power generation function, but also create a good thermal environment for buildings and further reduce building energy consumption. The curtain wall model is established by computational fluid dynamics software. For the given initial parameters, the data of temperature field and flow field are obtained through simulation, and the influence of curtain wall system operation on the indoor thermal environment of the building is theoretically studied. It is found that the solar photovoltaic and photothermal integrated louver curtain wall not only has good thermoelectric benefits, but also improves the indoor thermal environment. Especially in summer and winter, the air conditioning load is reduced, which has a good building energy saving effect and provides a basis for actual building construction.

Background:HLA-B51 is a definite risk factor for Behçet’s disease (BD). A coding variant of ERAP1, Hap10 – with low peptide-trimming activity – vastly potentiates this risk, but is mechanistically unclear1,2).Objectives:To test the hypothesis that low or absent ERAP1 activity alters CD8 T cell immunogenicity through changes in the HLA-B51 peptidome and shapes the CD8 T cell immune response in affected subjects.Methods:We generated HLA-B51+ERAP1 KO LCL clones using CRISPR-Cas9, performed mass spectrometry of the immunoprecipitated MHC-class I peptidome with subsequent computational deconvolution for HLA-B51-binding peptides. We then assessed single cell (ICS), bulk (ELISA) and proliferative (CFSE) CD8 effector (IFNg, granzyme B, perforin) T cell responses through stimulation of allogeneic donor cells with WT vs KO LCL and determined ERAP1 haplotypes in 49 untreated Turkish BD subjects with ocular and/ or major vascular involvement as well as healthy donors (HD) whose PBMC were profiled using 6 multicolour flow cytometry panels.Results:WT and KO peptidomes differed significantly (p+CD8 T cells. Analysis of 133 T, B, NK and monocyte cell populations revealed predominance of CD8 T and NKT cell subset in HLA-B51+/Hap10+ BD vs HLA-B51+/Hap10- BD and HD, accounting for 80% of all populations reaching significance (p0.8) or very large (>1.2).Conclusion:We show that absence of functional ERAP1 alters human CD8 T cell immunogenicity. This is mediated by an HLA-class I peptidome with propensity for longer peptides above 9mer and suggests loss or de-novo presentation of peptide-HLA-B51 complexes to cognate CD8 TCR. The reciprocal changes in antigen- experienced vs naive CD8 T cell subsets in affected subjects point to biologic significance of HLA-B51/Hap10 in BD. Collectively, our findings suggest that an altered HLA-B51 peptidome modulates immunogenicity of CD8 effector T cells in ERAP1-Hap10 carriers with BD and identify targets for future drug development.References:[1]Kirino, Y., G. Bertsias, Y. Ishigatsubo, N. Mizuki, I. Tugal-Tutkun, E. Seyahi, Y. Ozyazgan, F. S. Sacli, B. Erer, H. Inoko, Z. Emrence, A. Cakar, N. Abaci, D. Ustek, C. Satorius, A. Ueda, M. Takeno, Y. Kim, G. M. Wood, M. J. Ombrello, A. Meguro, A. Gul, E. F. Remmers, and D. L. Kastner. 2013. ‘Genome-wide association analysis identifies new susceptibility loci for Behcet’s disease and epistasis between HLA-B*51 and ERAP1’,Nat Genet, 45: 202-7.[2]Takeuchi, M., M. J. Ombrello, Y. Kirino, B. Erer, I. Tugal-Tutkun, E. Seyahi, Y. Ozyazgan, N. R. Watts, A. Gul, D. L. Kastner, and E. F. Remmers. 2016. ‘A single endoplasmic reticulum aminopeptidase-1 protein allotype is a strong risk factor for Behcet’s disease in HLA-B*51 carriers’,Ann Rheum Dis, 75: 2208-11.Disclosure of Interests:Arshed F. Al-Obeidi: None declared, Ann Cavers: None declared, Yesim Ozguler: None declared, Olivier Manches: None declared, Hua Zhong: None declared, Berna Yurttas: None declared, Beatrix Ueberheide: None declared, Gulen Hatemi Grant/research support from: BMS, Celgene Corporation, Silk Road Therapeutics – grant/research support, Consultant of: Bayer, Eli Lilly – consultant, Speakers bureau: AbbVie, Mustafa Nevzat, Novartis, UCB – speaker, Matthias Kugler: None declared, Johannes Nowatzky: None declared

Colloidal quantum dots are promising materials for near infrared light emitting diodes (NIR QLEDs) owing to the widely tunable wavelength of emitted light, high quantum efficiency, and full integration with solution processing techniques. However, the imbalance of charge carriers in NIR QLEDs greatly limits their performance, which in turn narrows the scope of their application. Here, we propose an approach for improving the brightness and stability of NIR PbS QLEDs through balancing the device current by an ultra-thin inorganic aluminum oxide (Al2O3) electron suppressing layer. This modification resulted in a 7.42 W/sr/m2 peak radiance at 1.3 μm wavelength. Moreover, the halide-capped PbS-based NIR QLEDs remained stable under constant current drive for over 144 h.

Based on the electricity market of Yunnan Province in China, a nonlinear method for long-term optimal operations for cascade hydropower plants with electricity-price curves is developed. This method takes into account multiple trading varieties that include matching, outside, and priority. With a large amount of historical market transaction data, the regression analysis method is used to determine a nonlinear relationship curve between electricity and price of each market variety. Moreover, the differences of the price characteristics in flood season and dry season are also considered. The fitted electricity-price curves are utilized to formulate an optimization model with maximizing generation benefit. The hydropower nonlinearities of this model are handled by the polynomial technique to obtain a solvable MINLP model. The simulation results demonstrate that the proposed method can reasonably determine the declared electricity quantity of cascaded hydropower plants in different trading markets depending on the electricity-price relationships. It is suggested that low-price electricity in flood season should be transferred to high-price electricity market in dry season since the total power generation benefit of the system can be effectively improved.

Three out of four people with diabetes will die of cardiovascular disease. However, the molecular mechanisms by which hyperglycemia promotes atherosclerosis, the major underlying cause of cardiovascular disease, are not clear.Three distinct models of hyperglycemia-associated accelerated atherosclerosis were used to identify commonly altered metabolites and pathways associated with the disease.Normoglycemic apolipoprotein-E-deficient mice served as atherosclerotic control. Hyperglycemia was induced by multiple low-dose streptozotocin injections, or by introducing a point-mutation in one copy of insulin-2 gene. Glucosamine-supplemented mice, which experience accelerated atherosclerosis to a similar extent as hyperglycemia-induced models without alterations in glucose or insulin levels, were also included in the analysis. Untargeted plasma metabolomics were used to investigate hyperglycemia-associated accelerated atherosclerosis in three disease models. The effect of specific significantly altered metabolites on pro-atherogenic processes was investigated in cultured human vascular cells.Hyperglycemic and glucosamine-supplemented mice showed distinct metabolomic profiles compared to controls. Meta-analysis of three disease models revealed 62 similarly altered metabolite features (FDR-adjusted p 0.05). Identification of shared metabolites revealed alterations in glycerophospholipid and sphingolipid metabolism, and pro-atherogenic processes including inflammation and oxidative stress. Post-multivariate and pathway analyses indicated that the glycosphingolipid pathway is strongly associated with hyperglycemia-induced accelerated atherosclerosis in these atherogenic mouse models. Glycosphingolipids induced oxidative stress and inflammation in cultured human vascular cells.Glycosphingolipids are strongly associated with hyperglycemia-induced accelerated atherosclerosis in three distinct models. They also promote pro-atherogenic processes in cultured human cells. These results suggest glycosphingolipid pathway may be a potential therapeutic target to block or slow atherogenesis in diabetic patients.

Background PD-L1 immunohistochemistry (IHC) data in China was less reported. We systematically investigated PD-L1 IHC data of Chinese patients generated by Origimed. Methods PD-L1 was stained using IHC on cancer samples from 2060 Chinese patients in Origimed since 2017. Written informed consent was obtained from each patient. IHC staining was performed on FFPE tissue sections using anti-PD-L1 antibody 28-8. Tumor Proportion Score (TPS) was applied on all the samples. We investigated PD-L1 TPS in lung adenocarcinoma (n = 893), lung squamous carcinoma (n = 172), liver cancer (n = 404), esophageal cancer (n = 186), colorectal cancer (n = 166), pancreatic cancer (n = 136) and gastric cancer (n = 103). We then further applied PD-L1 combined positive score (CPS) on the 103 gastric cancer samples. All the slides were reviewed by the same senior pathologist. 95% confidence interval (CI) was obtained by bootstrap. Information entropy (Shannon’s formula) was measured in natural units. Results The highest proportion of PD-L1 TPS > = 1% was observed in lung squamous carcinoma (49%; 95% CI: [43%, 59%]), followed by lung adenocarcinoma (25%; 95% CI: [22%, 28%]), liver cancer (14%; 95% CI: [11%, 18%]), esophageal cancer (12%; 95% CI: [8.1%, 17%]), pancreatic cancer (11%; 95% CI: [5.9%, 16%]), gastric cancer (7%; 95% CI: [1.9%, 12%]) and colorectal cancer (4%; 95% CI: [1.2%, 6.6%]). The proportion of PD-L1 CPS > = 1 for gastric cancer was 17% (95% CI: [9.7%, 24%]). In gastric cancer, information entropy of TPS and CPS was 0.40 and 0.78, respectively. Conclusions The proportion of PD-L1 TPS > = 1% in Chinese lung squamous cell carcinoma (49%) was much higher than that in lung adenocarcinoma (25%). PD-L1 CPS contained more information than TPS in gastric cancer. Thus, we recommend applying CPS to gastric cancer in China. Legal entity responsible for the study The authors. Funding Has not received any funding. Disclosure X. Pan: Full / Part-time employment: Origimed. Y. Dai: Full / Part-time employment: Origimed. D. Chen: Full / Part-time employment: Origimed. K. Wang: Full / Part-time employment: Origimed. X. Dong: Full / Part-time employment: Origimed. All other authors have declared no conflicts of interest.