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Aims: To evaluate the mandibular bone cortical of patients with mucopolysaccharidosis on panoramic radiograph, through radiomorfometric indices. Study Design: Case-control study. Place and Duration of Study: Sample: Department of Diagnostic Imaging of the Universidade Estadual da Paraíba, Campus VIII, in the city of Araruna, PB, between January and December of 2015. Methodology: Panoramic radiographs of sixteen patients with mucopolysaccharidosis and 32 controls, organized by gender and age, composed the sample. The mandibular panoramic index, gonial index, antegonial index and mental index were evaluated. Pearson's Chi-square test, Fisher's exact test and Mann-Whitney test were used to statistical analysis with a level of significance of 5.0%. Results: Mucopolysaccharidosis patients were mostly female (62.5%), with a mean age of 12.31 + 7.16 years, MPS VI (50.0%) being the most prevalent. Patients with mucopolysaccharidosis had higher values in the gonial (1.86+0.48), the antegonical (4.36+1.24) and the mental (5.24+1.21). However, only the antegoniac index presented a significant difference (P=0.047). Conclusion: The antegoniac index was higher in patients with mucopolysaccharidosis and the other radiomorphometric measures were similar to those observed in the control group. Apparently, mucopolysaccharidosis is not related to decreased bone to mandibular quality.

BACKGROUND/AIM Due to the increase in incarceration rates, the prison community has attracted much concern in the recent past. Although people in prison are often socially disadvantaged and vulnerable to a range of health problems, there is a lack of information on the oral health conditions of prisoners. Thus, the aim of this study was to survey the oral problems of a sample of the male incarcerated population of Brazil, focusing on dental trauma. MATERIAL AND METHODS The research was undertaken over a three-month period in 2017. It was a cross-sectional study of 756 prisoners of the Curado Prison Complex, located in Recife, PE. Using a previously calibrated examiner, dental trauma was measured with the Andreasen index. Etiology of dental trauma and socio-demographic data were collected with questions developed for this survey. Standard descriptive statistics were used to report frequency estimates. The chi-square test, Fisher's exact test, and Mann-Whitney U-test were used to compare groups. In addition, a binary logistic regression was performed to identify whether the studied variables could predict the occurrence of dental trauma. RESULTS The prevalence of dental trauma in the sample was 10.8% and most of the cases (42.7%) occurred due to violent events. A higher frequency of violent etiology was observed in cases that occurred during imprisonment (p = 0.037). Individuals that suffered dental trauma during incarceration were more likely to have been incarcerated for longer periods of time (p = 0.043). The main type of injury found was enamel and dentin fracture without pulp exposure (68%). The most affected tooth was the upper right central incisor (40%). CONCLUSION These results underline the high prevalence of dental trauma experienced by men in prison.

Background This study aimed to evaluate sociodemographic and clinical factors influencing overall survival (OS) in patients with oral squamous cell carcinoma (OSCC). Material and Methods Medical charts of 547 patients with OSCC from a public hospital in northeastern Brazil seen between 1999 and 2013 were evaluated. Survival analysis was performed using the Kaplan-Meier method. The influence of age, sex, ethnicity, clinical stage, anatomical location, type of treatment, and comorbidities on the patients’ prognosis was evaluated. Cox proportional hazards regression model was used to identify independent prognostic factors. Results The 5-year OS was 39%. Multivariate analysis showed that age < 40 years (HR = 2.20; 95%CI: 1.02-4.72) and a single treatment modality (HR = 1.91; 95%CI: 1.37-2.67) were associated with a poor prognosis, while early clinical stage resulted in better outcomes (HR = 0.38; 95%CI: 0.25-0.58). Conclusions OSCC patients in advanced clinical stages, diagnosed at a younger age, and submitted to a single therapeutic modality have a poorer prognosis. Key words:Head and neck cancer, oral cancer, oral squamous cell carcinoma, survival, prognosis.

Introduction: Apical dentoalveolar abscesses associated with sinusitis are very uncommon and may expose patients to unfavorable outcomes. Case-report: A 25-year-old female patient sought medical care due to severe, recurrent, long-term frontal facial pain and symptom relief through analgesics. A tomographic examination of the skull did not identify any pathological cerebral alterations. It did, however, evidence diffuse and irregular mucous thickening of all nasal cavities. The patient was referred to an otorhinolaryngologist, who diagnosed the condition as bilateral chronic inflammatory rhinosinusopathy. A rhinoscopy was performed and antibiotic associated with corticoid was prescribed. After the procedure, sinus infection diffusion to the dental tissues was observed, and the patient required emergency dental care due to diffuse facial cellulitis and swelling associated to tooth 26. Due to the absence of clinical signs indicative of carious infection, the condition was diagnosed as an uncommon case of acute dentoalveolar abscess of sinusal origin. After endodontic access for initial drainage, chemical-mechanical preparation of the root canals was performed, in two sessions. After 30 days, a tomography of the sinuses was performed, and results indicated a significant improvement of the infectious process. Due to the rarity of the case presented herein, it is of significant importance to understand the clinical, radiographic and protocol aspects of the case, in order to attend similar cases, as well as the joint action of the dental surgeon and the otorhinolaryngologist for rhinogenic and odontogenic infection management.

Objective: To compare salivary and serum biochemical levels in patients with chronic renal failure undergoing hemodialysis . Material and Methods: The sample was composed of 57 patients treated in Hemodialysis Reference Centers, from a state of Northeastern Brazilian, with age ≥21 years old with at least 3 months of hemodialysis treatment time. Serum data were obtained from records. Unstimulated and stimulated saliva were collected. Flow rate (mL/min) was measured. Spectrophotometry was performed for the measurement of salivary levels of calcium (570 nm), urea (340 nm), and creatinine (510 nm). Statistical analysis used Mann Whitney and Kruskal-Wallis tests (p

O termo currículo refere-se ao percurso seguido pelo estudante em uma instituição de ensino superior desde o momento em que inicia seu processo de formação profissional até a graduação. As Diretrizes Curriculares Nacionais (DCN) para os cursos de graduação em Odontologia, instituídas pela Resolução CNE/CES 3, de 19 de fevereiro de 2002, definem os princípios, fundamentos, condições e procedimentos da formação de cirurgiões-dentistas, primando pela formação de um profissional integral. As Instituições de Ensino Superior (IES) têm em mãos o desafio de construir projetos pedagógicos que operacionalizem esse conceito, de modo a atender as demandas da sociedade. Neste contexto, este estudo de abordagem qualitativa e exploratória objetivou analisar criticamente as matrizes curriculares de dois cursos de Odontologia, pertencentes a IES localizadas em regiões distintas do país. A metodologia utilizada considerou um modelo lógico para avaliação da formação do cirurgião-dentista com base nas DCN, proposto por Pessoa e Noro. Foram analisadas as dimensões referentes à integração entre os ciclos básico e profissionalizante, ao desenvolvimento de competências e habilidades desejáveis, a formação profissional, além do desenvolvimento do estágio curricular e atividades complementares. Foi verificado que as duas estruturas curriculares estão em consonância com os ideais preconizados pelas DCN, apesar de conterem pontos que não fortalecem a formação profissional do egresso. Observou-se que ambas as matrizes apresentam potencialidades e fragilidades, que inspiram discussões.

To perform an epidemiological and clinical analysis of cases of oral cancer (OC) and potentially malignant disorders (PMDs). This retrospective study was based on the analysis of data from 631 patients who attended a clinic of the Interdisciplinary League of Oral Cancer (LINCCO) of a public university of northeastern Brazil over a time period of 12 years. Sociodemographic, economic, and clinical variables were investigated. Descriptive, bivariate, and multivariate statistical analyses using Poisson regression were performed. During the analyzed period, 19.3% (n = 122) of cases were related to diagnoses of some type of OC or PMDs. The majority of patients were male (60.7%) and in the fifth (22.0%) or sixth (23.7%) decades of life. The reported smoking and alcohol consumption were 27.0% and 27.9%, respectively. The most prevalent lesions were actinic cheilitis (48.4%) and squamous cell carcinoma (SCC) (23.8%). The most affected anatomical region was the lower lip (45.1%). The prevalence of smoking was higher among those who presented with OC [prevalence ratio (PR) = 2.56, 95% confidence interval (CI) = 1.54–4.24, p

Opportunistic infections in oral cavity can cause serious complications in immunocompromised cancer patients, being quick and efficient treatments options essential. This article proposes to report two clinical cases of adolescent patients diagnosed with leukemia and who presented infectious conditions in the oral cavity, in which antimicrobial photodynamic therapy was used as a adjuvant therapy to abbreviate the course of oral lesions.

Purpose The aim of this study was to describe the relation between occlusal features and enzyme replacement therapy in patients with mucopolysaccharidoses. Materials and Methods A cross-sectional study was conducted. The sample consisted of 20 patients with mucopolysaccharidoses, 10 of whom were undergoing treatment at a hospital in northeast Brazil. Occlusal features were evaluated by clinical examination and panoramic radiography. A structured questionnaire was administered to evaluate the dental care of each patient. Pearson χ2, Fisher exact, and Mann-Whitney tests were used for data analysis, with a level of significance of 5%. Results Marked overjet (75%) and anterior open bite (70%) were the most frequent occlusal alterations, and 15% had Class III disorders. Radiography visualized the presence of impacted teeth (75%) and prolonged retention of deciduous teeth (65%). Patients with enzyme replacement therapy had a lower average maximum protrusion (P = .033). A total of 75% of mothers said they had not been advised to take their children to the dentist and 10% of children had never been to the dentist. Conclusion Patients with mucopolysaccharidoses exhibited notable occlusal alterations, especially marked overjet and anterior open bite. Enzyme replacement therapy seems to influence the maximum protrusion of patients.

Background Oral mucositis has become a major dose-limiting toxicity of antineoplastic treatment. Aim The aim of this study was to evaluate the effect of photodynamic therapy (PDT) and low level laser therapy (LLLT) on the treatment of chemotherapy-induced mucositis in pediatric patients. Methods An open, controlled, and blind, randomized clinical trial was conducted with 29 patients, from 10 months to 18 years old, who were divided into two groups. Group A was submitted to photodynamic therapy (0.01% Methylene Blue and red laser, λ660 nm) with 3J energy per point; and Group B submitted to low level laser therapy (λ660 nm) with 1J energy per point. The results were evaluated by using the WHO and ChIMES mucositis scales. The Chi-square, Exact Fisher, Student’s-t and Mann-Whitney tests, and the mixed linear regression model were used for comparison between the groups, with the maximum error admitted of 5%. Results There was no difference between the groups as regards the number of sessions necessary for clinical cure of the oral lesions (p = 0.954) or reduction in pain reported by the patients (p = 0.258; p = 0.486). Within each group, however, there was significant reduction in pain (p = 0.032; p = 0.003). The number needed to treat (NNT) was 4.75. Conclusions PDT or LLLT could be used for treatment of oral mucositis in children/young patients. Each were well tolerated and presented satisfactory results in reducing pain associated with the lesion.

The study aimed to analyze the situation of Brazilian dental education considering the exceptionality of the COVID-19 pandemic. An observational and analytical study was conducted with two cross-sections, using questionnaires sent to all course coordinators in Brazil, in the 1st semester of 2020 and in March 2021. At onset of the pandemic, the institutions interrupted on-site activities. There was significant association between private institutions and offering remote lectures and using these resources before the pandemic. The public sector was associated with not teaching remote lectures and not using these resources previously. Public institutions had a greater degree of difficulty in the use and access to technologies for online activities by professors and students, as well as a lower degree of preparation in relation to biosecurity protocols to resume the clinical activities. Impacts were identified in different dimensions of dental education related to the development of practical activities and the establishment of new biosecurity protocols. Nearly all private courses did not suspend activities or did it for less than one month and resumed clinical or laboratory activities at some point during the surveyed period, while public institutions required an average of 5 months for such reorganization. The COVID-19 pandemic substantially increased the use of digital media in Brazilian dental education. From this assessment, there are financial limitations of the public sector to adapt the infrastructure to the requirements of the current biosecurity protocols. In general, students are receiving support from the institution and the coordinators identified negative impacts in different dimensions of dental education, notably in the establishment of new biosecurity protocols, adequacy in the physical structure and teaching-learning process.

This was a documentary research, using data from the student questionnaire of ENADE 2016. We analyzed the answers given by students who completed a public higher education course in Dentistry at a public institution in a Capital city in Northeastern Brazil. The IES data were filtered from the ENADE 2016 microdata worksheet, using the IES code, as obtained from the electronic system of the MEC (eMEC). The sociodemographic variables were used to characterize the profile of the graduates of the night course. The answers to the questionnaire were grouped into categories of positive, neutral or negative responses, for the three sections of the questionnaire: didactic-pedagogical organization, infrastructure and physical facilities of the course, and expansion of academic and professional development. The latter was analyzed comparatively between the night course(?)and full-time students of the same IEH, by using the Chi-square tests and Fisher's exact test applied with 95% confidence. The sociodemographic profile included a group of single, white, males, with a mean age of 28.9 years. In the Quality assessment of the didactic-pedagogical organization, physical infrastructure and facilities of the course, students' perceptions were positive for the majority of the subcomponents of the questionnaire. There was statistically significant difference between the night and full-time course students' responses, in terms of opportunities for extension and exchanges and / or international internship. The perception of the graduates, presented positive results, conferring a criterion of quality. The study indicated that the policy of expansion of higher education to include the night classes remained fragmented as extracurricular activities in the development of these (night) students at the public university.

Introduction Actinic cheilitis is a inflammatory condition affecting mainly the lower lip and it is caused by chronic and excessive exposure of the lips to the ultraviolet radiation in sunlight. Objective Identifying clinical and histopathologic characteristics in 40 cases histopathologically diagnosed as actinic cheilitis. In addition, to investigate possible associations between these aspects. Method Defined as an observational, transversal, retrospective and descriptive study, it registered data regarding age, gender, occupation, symptomatology, records of sun exposure, frequency of sunblock use, tabagism, skin color, clinical aspect and histopathological classification. The data was submitted to the chi square test of Pearson (p

The aim of this double-blind randomized study was to evaluate the biocompatibility of resin-modified glass ionomer cements (RMGIC) by means of morphological and immunohistochemical analyses. RMGICs were selected and divided into four groups: Group CK (Crosslink Orthodontic Band Cement); Group RS (Resilience Light Cure Band Cement) Group RMO (RMO Band Cement), Group TP (Transbond Plus Light Cure Band), and Group C (Control-polyethylene). The materials were implanted in rat subcutaneous tissues, randomly selected for this study. After time intervals of 7, 15, and 30 days the tissues were submitted to morphological analysis. In immunohistochemical analysis, the immuno-marking of antibody CD68 was evaluated. The results obtained were statistically analyzed by the Kruskal-Wallis and Dunn tests (p < .05). In the morphological analysis after 7 days, Groups RS, RMO and TP showed more intense inflammatory infiltrate (p = .004) and only Group RMO presented greater intensity of multinucleated giant cells (p = .027). In the immunohistochemical analysis, Groups RMO and RS were observed to present a larger quantity of CD68+ (p = .004) in the time interval of 7 days and only Group RMO presented statistically significant difference for this parameter after 15 days (p = .026). In the time interval of 30 days, Group RMO presented the largest quantity of multinucleated giant cells (p < .004). The RMGICS Crosslink and Transbond Plus provided significantly better tissue biocompatibility than the Resilience and RMO Cements.

A 17-year-old male sought countryside hospital with throat pain and afebrile for 8 days, being prescribed cephalexin. Due to worsening of clinical condition with lingual protrusion and progressive loss of voice, he returned other times to the service, when he was referred for health center. He was transferred to emergency care unit and conducted to capital hospital for drainage of retropharyngeal abscess. Patient presented dyspnea, initiating treatment with dexamethasone, with clinical improvement of the tumor, but when suspended, the tumor grew up. He was transferred to intensive care unit and submitted to a computed tomography of skull, tracheostomy, gastrostomy, and excisional biopsy of the lesion that occupied all the oropharynx. He presented cardiorespiratory arrest, seizures, and respiratory infection. Results of biopsy and immunohistochemistry diagnosed Burkitt’s lymphoma. Patient was submitted to chemotherapy with regression of the lesion and return the tongue to the normal conditions.

Objective: To analyze the determinant clinical and histologic aspects in the establishment of the diagnosis of the glandular odontogenic cyst (GOC).Study Design: A cross-sectional study was performed in 2 oral pathology services. All slides of GOCs were reviewed and clinical data were obtained from the patient records. The determination of the diagnosis followed predetermined microscopic parameters according to the World Health Organization. Statistical analysis was performed in order to identify the predictive parameters for the diagnosis of GOC. Results: From the 9 patient cases of GOCs, 55.5% were male, with a mean age of 50.6 years, and 66.6% were located in the mandible. All cases presented with intraepithelial microcysts or duct-like spaces, clear or vacuolated cells, variable thickness of the cyst lining, and papillary projections into the lumen. Multiple compartments, surface eosinophilic cuboidal cells, and epithelial spheres or plaque-like thickenings were observed in 8 (88%) cases. Apocrine snouting of hobnail cells were present in 6 (66%), mucous goblet cells in 3 (33.3%), and cilia in only 1 (11%). Conclusion: The association between the predictive clinical and histopathological aspects for the diagnosis of this rare lesion is fundamental, since GOC has the potential to mimic other potentially more aggressive lesions.

Objective: To evaluate and compare the efficacy of photodynamic therapy and photobiomodulation in the control of chemotherapy-induced oral mucositis in pediatric patients. Study Design: A superiority, randomized, open, controlled, and triple-blind clinical trial consisting of 54 patients aged 10 months to 18 years and totaling 91 cases of oral mucositis were drawn for allocation into 2 groups. Group A (experimental) was subjected to photodynamic therapy (0.01% methylene blue, laser of 660 nm, 100 mW, 0.028 cm2, 3 J) and group B (control) to photobiomodulation (660 nm, 100 mW, 0.028 cm2, 1 J). For evaluating oral mucositis, the World Health Organization and Children's International Mucositis Evaluation Scale (ChIMES) scales were used, and the patients were followed up daily until clinical cure of the lesions. The χ2test, Fisher exact test, Student t test and Mann-Whitney U test, in addition to the mixed linear regression and Poisson models, were used for comparison, with the maximum error admitted of 5%. Results: There was no difference between the groups in regard to the number of sessions necessary for clinical cure of the oral lesions (P = .058), reduction in pain, and difficulty with swallowing or chewing (P> .05). Within each group, however, the reductions were significant (P

Objective: To determine the demographic profile of all histologically diagnosed odontogenic cysts (OC) and nonodontogenic cysts (nOC) over a 30-year period in a Brazilian population. Study Design: A descriptive cross-sectional study was performed with OC and nOC to obtain information about epidemiologic data. The diagnosis followed the World Health Organization (2017) parameters of a descriptive statistical analysis. Results: A total of 6235 lesions were diagnosed. Of these, 544 (8.72%) corresponded to OCs and nOCs. Radicular cyst was the most frequently inflammatory OC (81.76%). Among the development of OCs and nOCs, the dentigerous cyst was the most frequent (56.78%), followed by odontogenic keratocyst (34.67%) and glandular odontogenic cyst (3.01%). The inflammatory OCs were most common in female (53.4%) patients, with a mean age of 34.4 years, and the maxilla (56.6%) was the most affected anatomic site. In addition, the OCs and nOCs were more frequent in female (62.8%) patients, with a mean age of 29.2 years, located in the mandible (66.8%). Conclusion: Knowledge of the epidemiologic profile, clinical aspects, and pathologic aspects of OC and nOC provides more accurate data about diagnosis and appropriate treatment.

O tirosol (2- (4-hidroxifenil) etanol) e o hidroxitirosol (2- (3,4-di-hidroxifenil) etanol) são um dos maiores representantes dos compostos fenólicos encontrados nas azeitonas, no azeite de oliva e no vinho. Possuem alto poder antioxidante, anti-inflamatório, antiviral e antitumoral e são alvo de vários estudos na área médica. O objetivo deste trabalho foi de avaliar os resultados do tirosol e hidroxitirosol na literatura publicada no intuito de direcionar as informações sobre a aplicabilidade de tais compostos fenólicos à área odontológica. Foi realizada uma revisão integrativa da literatura publicada nos últimos 20 anos, com a finalidade de acessar evidências mais recentes a respeito do assunto, sem restrição quanto ao idioma. Foi concluído que, embora existam poucos estudos acerca da aplicabilidade terapêutica do tirosol e do hidroxitirosol na odontologia, e muitos destes in vitro, os achados mostraram o potencial que estes produtos possuem para a sua aplicação na odontologia. Tais compostos podem ser utilizados em diversas áreas clínicas, principalmente por possuir atividades anti-inflamatória, antioxidante e antitumoral.

Objective: To evaluate the knowledge level of dentists about oral cancer (OC) in Campina Grande, Paraiba, Brazil. Material and Methods: It was an observational, transversal, descriptive and analytical study. It was applied 200 structured forms. The sample was chosen for convenience. Statistical associations were performed using the Chi-square and Fisher’s exact tests (P

Orthokeratinized odontogenic cysts are developmental odontogenic cysts, presenting with low frequency, low rate of recurrence and their ethiopathogenesis is unknown. Radiographically, they show a radiolucent area in the mandibular posterior region. The aim of this report is to describe an unusual case of orthokeratinized odontogenic cysts, radiographically exhibiting radiopaque areas with an aspect of calcifications in the lesion. Based on this, the clinical hypothesis of ameloblastic fibro-odontoma was suggested. After incisional biopsy and microscopic analysis, the conclusive diagnosis was orthokeratinized odontogenic cysts. The radiopaque foci were observed to be associated with a foreign body reaction. The patient was submitted to surgery under local anesthesia, with intraoral access for complete excision of the lesion and to re-establish esthetics. After follow-up of 24 months there were no signs of recurrence. Knowledge of this type of reaction is important because of the risk that the lesion may mimic a potentially more aggressive lesion, affecting the choice of treatment.

Patient N.J.E., a 69-year-old black male liver recipient, complained of pain in the oral cavity. Clinical examination revealed ulcerated lesions on the dorsal surface of the tongue, right buccal mucosa, and lower right vestibule. In view of clinical findings and medical history, the diagnostic hypothesis suggested an oral infection. The culture was carried out with the purpose of microbiologic analysis (swab) along with incisional biopsy of tongue lesion, leading to a diagnosis of Actinomyces infection. The patient was treated with specific antimicrobials, oral topical solutions, and, as an adjuvant, antimicrobial photodynamic therapy (aPDT). aPDT consisted of daily application of the photosensitizer on the lesions, and after 5 minutes, the low-level light laser was applied in the visible red spectrum (660 nm) with fixed power of 100 mW and energy density of 6 J/cm². After 15 days, good clinical tissue recovery was observed; however, because of other systemic complications, the patient died.

Patient J.C., 37 years old and male, was diagnosed as having a poorly differentiated metastatic squamous cell carcinoma of the rhinopharynx treated with radiotherapy and chemotherapy in 2008 with complete remission and has been in medical follow-up since then. In 2017, he attended a dentistry service, reporting the need of dental extraction. The clinical examination revealed remaining teeth in a poor state of preservation and also showed a bone exposure area, corresponding to the edentulous region of the right lower third molar, of elliptical shape and approximately 2 cm. Panoramic radiograph showed bone rarefaction in the reported region. J.C. stated that a dental surgical procedure had been performed on this area 1 month earlier. The diagnostic hypothesis was suggestive of osteoradionecrosis. Oral care protocol was prescribed, using mouthwashes with sodium bicarbonate, 0.12% chlorhexidine digluconate, and 10-volume hydrogen peroxide. The patient was followed up biweekly, and after 4 months, the complete clinical repair was observed without painful symptomatology.

A 41-year-old male patient, a white farmer, was referred to the stomatology clinic diagnosed as having actinic cheilitis. Clinically, atrophic and leukoplastic areas were observed throughout the lower lip, and loss of the border between the red lip skin and the cutaneous portion. An incisional biopsy was performed in the leukoplastic area, and histopathologic examination showed atrophic and atypical stratified orthokeratinized pavement epithelium with severe oral epithelial dysplasia. The therapeutic approach was the removal of all leukoplastic areas using the high-intensity diode laser for re-epithelialization of the affected mucosa. Proper follow-up is being performed every 3 months, and after 9 months, no signs of relapse were observed. Because of the potential for malignancy of actinic cheilitis and the presence of dysplastic epithelial alterations, an early approach is justified. The vaporization of the labial tissues with high-intensity diode laser was effective in superficial removal of affected tissues.

Objective To evaluate the effect of antimicrobial photodynamic therapy (PDTa) on the treatment of chemotherapy-induced mucositis in pediatric patients. Study Design It was a pilot study of an open, controlled, and blind randomized clinical trial conducted with 29 patients, with ages ranging from 10 months to 18 years, who were divided into 2 groups. Group A was submitted to PDTa with 0.01% methylene blue and red laser with 3 J energy per point; group B was submitted to photobiomodulation with wavelength of 660 nm and 1 J energy per point. The chi-square, Fisher exact, Student's t, and Mann-Whitney tests and the mixed linear regression model were used for comparison between the groups, with the maximum error admitted of 5%. Results There was no difference between the groups regarding the number of sessions necessary for clinical cure of the oral lesions (P = .95) or reduction in pain (P = .26; P = .49). Within each group, however, there was significant reduction in pain (P = .03; P = .003). Conclusion PDTa could be used for control of oral mucositis in children/young patients. It was well tolerated and presented satisfactory results, the same as photobiomodulation in reducing pain associated with the mucositis.

The aim of the present study was to perform anin vitroanalysis of the antimicrobial and antiproliferative potential of an extract fromAnadenanthera colubrina(Vell.) Brenan (angico) and chemically characterize the crude extract. Antimicrobial action was evaluated based on the minimum inhibitory concentration (MIC), minimum bactericidal/fungicidal concentration, and the inhibition of formation to oral biofilm. Cell morphology was determined through scanning electron microscopy (SEM). Six strains of tumor cells were used for the determination of antiproliferative potential. The extract demonstrated strong antifungal activity againstCandida albicansATCC 18804 (MIC=0.031 mg/mL), with similar activity found regarding the ethyl acetate fraction. The extract and active fraction also demonstrated the capacity to inhibit the formation ofCandida albicansto oral biofilm after 48 hours, with median values equal to or greater than the control group, but the difference did not achieve statistical significance(P>0.05). SEM revealed alterations in the cell morphology of the yeast. Regarding antiproliferative activity, the extract demonstrated cytostatic potential in all strains tested. The present findings suggest strong antifungal potential forAnadenanthera colubrina(Vell.) Brenan as well as a tendency toward diminishing the growth of human tumor cells.

Background Actinic cheilitis (AC) is a potentially malignant disorder of the lip caused by exposure to solar radiation. Objectives This study was conducted to evaluate the clinicopathologic profile of cases of AC and to verify associations with the degree of dysplasia. Methods This retrospective study analyzed data for 40 patients with AC. Demographic, clinical, and histopathologic data were evaluated. Sections measuring 5 μm in thickness were cut, deparaffinized, and stained with hematoxylin and eosin for histologic examination. The degree of epithelial dysplasia was graded using the criteria defined by the World Health Organization. Two calibrated oral pathologists analyzed the slides. Results Analysis of the AC patients sampled showed that 75.0% were male (P = 0.002), 80.0% were aged ≥40 years (P

Background: The studies found in the literature associate the immunoexpression of hMLH1 and hMSH2 proteins with histologic aspects, but do not correlate it with clinical and epidemiological data. Objective: To evaluate the immunoexpression of hMLH1 and hMSH2 in actinic cheilitis, correlating it with clinical characteristics. Methods: We analyzed 40 cases. Histological and immunohistochemical analyses were performed. The following clinical variables were evaluated: gender, age range, ethnicity, clinical aspect and occupational sunlight exposure. Statistical evaluation included the Student t-test, while the significance level was set at 5%. Results: Greater immunoexpression of hMLH1 and hMSH2 was observed in females, individuals aged over 40, and mixed-race/black patients. Furthermore, the immunoexpression of these proteins was greater in actinic cheilitis with a white-colored appearance and in patients without occupational sunlight exposure. No statistical differences were observed for the variables studied. Conclusion: This study uncovered variations of hMLH1 and hMSH2 protein expression upon evaluation of clinical aspects in actinic cheilitis.

Epithelial-myoepithelial carcinoma was first described by Danath et al. in 1972 and is classified as a rare low-grade biphasic neoplasm of the salivary glands. This case report presents a male patient who had a lesion in the oral mucosa with a history of recurrence of the tumor. The outcome resulted in a profile consistent with an epithelial-myoepithelial carcinoma with a high degree of transformation. The case highlights the importance of histopathological evaluation of oral lesions, which occasionally may not present typical clinical aspects of malignant lesion.

The aim of this article is to report the case of a 23-year-old female patient that sought dental service for examination of an asymptomatic slow-growing large lump in the mandibular gingiva causing displacement of the right first molar. Excisional biopsy, histopathological analysis, Alcian blue/periodic acid-Schiff (PAS) staining and immunohistochemistry analysis for S-100 were performed. The diagnosis established was oral focal mucinosis. After three years, the patient is still under follow-up, without any recurrences. Although cases of oral focal mucinosis of this particular size are rare, this entity should be considered in the differential diagnosis of oral lesions located in the gingiva.

Desmoplastic melanoma is a rare variant of malignant melanoma and one of the main causes of clinical and histological misdiagnosis in the realm of melanocytic neoplasms. Its relatively innocuous clinical appearance and the absence of pigmentation usually lead to a clinical misdiagnosis. The authors report a case of desmoplastic melanoma located in the lower lip of a 42-year-old man and review the literature regarding pathogenesis, clinicopathological features, differential diagnosis, and therapeutic management of desmoplastic melanomas.

The aim of the present study was to clinically, morphologically, and immunohistochemically correlate the expression of cytokeratins (CKs) 7, 10, 13, 14, 16, and 19 in 30 cases of tongue squamous cell carcinoma (SCC) with disease outcome, metastases, clinical stage (tumor, node, metastasis [TNM]), and histological grade of malignancy proposed by Bryne. Statistical analysis (χ2 test) showed that only histological grading was not significantly correlated with the clinical variables. CK expression varied in the samples analyzed. CK 10 expression was significantly correlated with the presence of metastases, and the expression of CK 16 was related to disease outcome and also to TNM stages III and IV. These results indicate that metastases and TNM are effective prognostic indicators. The histological grading proposed by Bryne did not reflect the biological behavior of the tongue SCC cases studied. Analysis of some intermediate CK filaments can reflect the biological behavior and aggressiveness of some tongue SCCs.

Department of Dentistry, School of Dentistry, State University of Paraiba, Campina Grande, PB, Brazil Post-Graduation Program in Medical Sciences, School of Medicine, University of Brasilia (UnB), Brasilia, DF, Brazil Department of Pathology, Federal University of Pernambuco, Recife, PE, Brazil Laboratory of Neuromodulation & Center for Clinical Research Learning, Harvard Medical School (HMS), Charlestow-Massachusetts, USA

Partial facial hemihyperplasia is a rare maxillofacial dysmorphosis of debatable etiology, and is frequently associated with relatively serious appearance and functional disorders depending on the degree of hyperplasia. We report here a case of partial facial hemihyperplasia with 9 years of evolution, describing the alterations observed during the follow-up period and discussing the main aspects of this poorly known entity.

Summary Ameloblastic fibro-odontoma has been defined by the World Health Organization (WHO) as “a lesion resembling ameloblastic fibroma” which also shows inductive alterations that lead to the formation of enamel and dentin. It is a rare lesion and is classified among odontogenic lesions as an epithelium tumor containing ectomesenchyme with or without the formation of dental hard tissue. We report here the case of a unusual ameloblastic fibro-odontoma seen in a 4-year-old boy and discuss the clinical, radiographic, histopathologic and therapeutic aspects of this tumor.

Resumen Antecedentes y metodos El papel de la respuesta inmune en la citopatogenia de la enfermedad periodontal constituye tema de estudio de diversos investigadores. El objetivo de este trabajo fue investigar a traves de inmunohistoquimica la densidad y el patron de distribucion de la celulas inflamatorias mononucleadas (linfocitos T helper e linfocitos B), utilizando los anticuerpos anti CD4 y anti CD20 en 17 casos de gingivitis cronica y 25 casos de periodontitis cronica. Resultados Fue observada inmunopositividad para las celulas CD4 en un patron difuso por todo tejido conectivo de todos los casos de gingivitis cronica. De los 25 casos de periodontitis cronica, 22 (88%) presentaron un patron de distribucion en pequenos focos aislados. Con relacion a las celulas CD20, 16 casos de gingivitis cronica exhibieron positividad en un patron focal de distribucion tanto en posicion yuxtaepitelial como en areas distantes del epitelio (10 casos, 62,5%). En los casos de periodontitis cronica fue observada marcacion positiva para el anticuerpo anti CD20 en 22 casos (88%), predominando el patron focal en posicion yuxtaepitelial y distante del epitelio (17 casos, 77,3%). El analisis estadistico no mostro diferencia significativa en la densidad de celulas CD4 y CD20 positivas entre los casos de gingivitis y periodontitis cronica. Conclusion Fue concluido que a pesar de no ser constatada tal diferencia estadistica, hubo una mayor densidad de linfocitos B en ambos grupos, sugiriendo una mayor participacion de la respuesta inmune humoral el los diferentes estadios de la enfermedad periodontal.

Osteoblastoma is a benign neoplasia and is uncommon in the jaws. In some cases, this lesion presents extremely aggressive local characteristics and is termed aggressive osteoblastoma. Because the clinical, radiographic and histopathologic characteristics are similar to those of a variety of benign and malignant tumors, it poses a diagnostic dilemma. This report presents a case of an aggressive osteoblastoma in the mandible and discusses the differential diagnosis of this lesion. A 13-year-old white male sought the Stomatology Clinic at the State University of Paraíba, Campina Grande, PB, Brazil, complaining of asymptomatic swelling on the left side of his face. Cone-beam computerized tomography showed a multilocular, hypodense bone lesion, located in the body of the left mandible and lower third of the ascending ramus. The initial diagnostic hypothesis was juvenile ossifying fibroma or osteosarcoma. After histopathologic examination, the final diagnosis was aggressive osteoblastoma. Surgical resection with a safety margin was performed. There was no evidence of recurrence after a follow-up period of 4 years. O osteoblastoma é uma neoplasia benigna e incomum nos maxilares. Em alguns casos esta lesão apresenta características locais extremamente agressivas, sendo denominada osteoblastoma agressivo. Devido às características clínicas, radiográficas e histopatológicas serem similares a uma variedade de tumores benignos e malignos, o seu diagnóstico é um dilema. Este relato apresenta o caso de um osteoblastoma agressivo na mandíbula e discute o diagnóstico diferencial desta lesão. Paciente, branco, 13 anos de idade, foi atendido na Clínica de Estomatologia da Universidade Estadual da Paraíba, Campina Grande, PB, Brasil, queixando-se de aumento de volume assintomático do lado esquerdo de sua face. A tomografia computadorizada de feixe cônico revelou uma lesão óssea hipodensa multilocular, localizada no corpo do lado esquerdo da mandíbula e no terço inferior do ramo ascendente da mandíbula. A hipótese diagnóstica foi de fibroma ossificante juvenil e osteosarcoma. Após exame histopatológico, o diagnóstico final foi osteoblastoma agressivo. Foi realizada ressecção cirúrgica com margem de segurança. Não houve sinais de recorrência após 4 anos de acompanhamento.

An increasing incidence of oral squamous cell carcinoma (OSCC) in individuals younger than 45 years has been observed in recent years. OSCC in younger patients differs in terms of biological behavior and prognosis with the disease being more aggressive than in older patients. The aim of this study was to analyze the immunohistochemical expression of galectins-3 and -7 in 32 cases of OSCC in young patients and to correlate this expression with clinical and morphological parameters. All cases of OSCC of the sample were diagnosed at oncology referral hospitals in Paraiba, Brazil, between 2002 and 2012. Clinical data were obtained from the patient records. Histological malignancy grading systems proposed by Bryne et al. (J Pathol 166:375-381, 1992) and the World Health Organization (In: Pathology and genetics of head and neck tumours: Word Health Organization classification of tumours, 2005) were used for morphological analysis. Immunohistochemistry was performed by the streptavidin-biotin technique using anti-galectin-3 and -7 antibodies. The results were analyzed statistically by the Chi-squared and Fisher exact tests (p < 0.05). Immunoexpression of galectin-3 was observed in 65.6 % of the cases analyzed, but showed no significant association with any of the variables studied (clinical staging; histological malignancy grading systems). Immunoexpression of galectin-7 was observed in 96.9 % of cases and was significantly associated with histological malignancy grading systems (p < 0.05). In conclusion, the results suggest the use of galectin-7 as marker of biological behavior and tumor progression in OSCC in young patients.

The oral squamous cell carcinoma (OSCC) very often affects subjects above the sixth decade of life. However an increasing incidence has been observed in younger individuals, below 40 years. We conducted a systematized review of the current clinical, histopathological and therapeutic aspects of OSCC in young patients. Our work included studies that addressed OSCC involving young patients in the period 2007 2012, and which were indexed in PubMed. Initially, 499 articles were obtained; after refinement, 340 articles had their titles and abstracts evaluated, with 17 included in the sample. The majority of studies reported male predominance (87.5%), association with tobacco and/ or alcohol use (66.6%), advanced clinical stages at diagnosis (77.7%) and, at histopathology, moderately differentiated tumors (72.7%). Based on the results, we believe there are differences in the factors associated with pathogenesis, biological behavior and prognosis in young patients, since most studies show more rapid and aggressive tumor progression in this age group. We suggest the conduction of research focusing on the pathogenesis and carcinogenesis of OSCC in young patients, thereby searching for better scientific evidence. O carcinoma de células escamosas oral (CCEO) acomete mais frequentemente indivíduos em uma faixa etária acima da sexta década de vida. No entanto, tem-se observado uma crescente incidência em indivíduos mais jovens, abaixo dos 40 anos de idade. Realizou-se uma revisão sistematizada dos aspectos clínicos, histopatológicos e terapêuticos atuais do CCEO em pacientes jovens. Foram incluídos os estudos que abordavam o CCEO envolvendo indivíduos jovens no período de 2007-2012 e indexados na base de dados PubMed. Dos 499 artigos obtidos inicialmente, 340 tiveram os títulos e resumos avaliados, com 17 sendo incluídos na amostra. A maioria dos estudos relatou predominância do sexo masculino (87,5%), associação com uso de tabaco e/ou álcool (66,6%), estágios clínicos mais avançados da doença (III e IV) ao diagnóstico (77,7%) e, histopatologicamente, tumores moderadamente diferenciados (72,7%). Com base nos resultados encontrados, acredita-se que possa haver diferenças quanto aos fatores associados à etiopatogenia, ao comportamento biológico e ao prognóstico em pacientes jovens, uma vez que grande parte dos estudos mostra uma progressão tumoral mais rápida e agressiva nessa faixa etária. Sugere-se o desenvolvimento de pesquisas com foco na etiopatogenia e na carcinogênese do CCEO em pacientes jovens, buscando, assim, melhores evidências científicas.

Johanson–Blizzard syndrome is a hereditary disorder extremely rare. The characteristic features include aplastic alae nasi, midline ectodermal scalp defects, deafness, dental abnormalities and malabsorption related to pancreatic exocrine deficiency. This paper presents a case of an 18-year-old patient with Johanson–Blizzard syndrome and emphasizes the importance of knowledge of the potential anaesthetic concerns of this syndrome for providing appropriate treatment for these patients.