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A distributed zero-sequence-current (ZSC) carrier signal injection via current transformer (CT) is proposed for underground cable single-phase-to-ground fault location in neutral isolated medium voltage (MV) distribution networks. High-frequency ZSC carrier signal is directly injected to a high-voltage underground cable of an energized distribution network via CT. The injected carrier signal travels along the cable to the receiving center in the substation, and is processed for quick fault line selection and fault location. No external power supplies or signal generators are needed due to the self-contained nature of the injector. The device can be constructed as a sleeve to be mounted around the underground power cable. This permits economical retrofitting to existing installations of power line communication (PLC) devices. In this paper, the operational principle and the application considerations for such an injection device and fault location tricks are explained, followed by the theory behind the proposed technique. Finally, MATLAB based numerical simulations are performed and a low-voltage prototype is tested to verify the validity of the proposed approach.

Irritable bowel syndrome (IBS) is a common refractory disease. Chinese medicine (CM) has remarkable efficacy and advantages on the treatment of IBS. This review summarized the articles focusing on the treatment of IBS with CM to sum up the latest treatment methods for IBS and the underlying mechanisms. Literature analysis showed that prescriptions, acupuncture, and moxibustion are the primary methods of CM treatment for IBS. The potential mechanism centers on the regulation of the enteric nervous system, the alleviation of visceral hypersensitivity, the stability of intestinal flora, and the regulation of the immune system.

Cancer is still an insurmountable problem for humans and critically attacking human health. In recent years, natural products have gained increasing attention in the field of anti-tumor due to their extensive sources and minimal side effects. Maslinic acid (MA), a pentacyclic triterpene acid mainly derived from the olive tree (Olea europaea L.) has been confirmed to possess great anti-cancer effects. This paper reviewed the inhibitory effect of MA and its derivatives on lung cancer, colon cancer, ovarian cancer, gastric cancer, lymphatic, leukemia, breast cancer, pancreatic cancer, melanoma, prostate cancer, renal cell carcinoma, gallbladder cancer, and bladder cancer, among others. MA inhibited the proliferation of various tumor cells and showed lower IC50 values in melanoma 518A2 cells and gastric cancer MKN28 cells compared with other cell lines. A series of semi-synthetic derivatives obtained by modifying MA chemical structure have been shown to have high cytotoxicity to human tumor cell lines, but low cytotoxicity to non-malignant cells, which is conducive to developing its potential as a chemotherapeutic agent. These studies suggest that MA derivatives have broad prospects in the development of antitumor therapeutics in the future and warrant further study.

Ethnopharmacological relevance Many studies have shown the beneficial effects of aconite water-soluble alkaloid extract (AWA) in experimental models of heart disease, which have been ascribed to the presence of aconine, hypaconine, talatisamine, fuziline, neoline, and songorine. This study evaluated the effects of a chemically characterized AWA by chemical content, evaluated its effects in suprarenal abdominal aortic coarctation surgery (AAC)-induced chronic heart failure (CHF) in rats, and revealed the underlying mechanisms of action by proteomics. Methods Rats were distributed into different groups: sham, model, and AWA-treated groups (10, 20, and 40 mg/kg/day). Sham rats received surgery without AAC, whereas model rats an AWA-treated groups underwent AAC surgery. after 8 weeks, the treatment group was fed AWA for 4 weeks, and body weight was assessed weekly. At the end of the treatment, heart function was tested by echocardiography. AAC-induced chronic heart failure, including myocardial fibrosis, cardiomyocyte hypertrophy, and apoptosis, was evaluated in heart tissue and plasma by RT-qPCR, ELISA, hematoxylin and eosin (H&E) staining, Masson's trichrome staining, TUNEL staining, and immunofluorescence staining of α-SMA, Col Ⅰ, and Col Ⅲ. Then, a proteomics approach was used to explore the underlying mechanisms of action of AWA in chronic heart failure. Results AWA administration reduced body weight gain, myocardial fibrosis, cardiomyocyte hypertrophy, and apoptosis, and rats showed improvement in cardiac function compared to model group. The extract significantly ameliorated the AAC-induced altered expression of heart failure markers such as ANP, NT-proBNP, and β-MHC, as well as fibrosis, hypertrophy markers MMP-2 and MMP-9, and other heart failure-related factors including plasma levels of TNF-α and IL-6. Furthermore, the extract reduced the protein expression of α-SMA, Col Ⅰ, and Col Ⅲ in the left ventricular (LV), thus inhibiting the LV remodeling associated with CHF. In addition, proteomics characterization of differentially expressed proteins showed that AWA administration inhibited left ventricular remodeling in CHF rats via a calcium signaling pathway, and reversed the expression of RyR2 and SERCA2a. Conclusions AWA extract exerts beneficial effects in an AAC-induced CHF model in rats, which was associated with an improvement in LV function, hypertrophy, fibrosis, and apoptotic status. These effects may be related to the regulation of calcium signaling by the altered expression of RyR2 and SERCA2a.

In photovoltaic power generation, UPS and other applications, DC/AC converters with a low input DC voltage are essentially used. However, this type of converter is commonly put to use the traditional two-level converting topology, which results problems of high harmonic content in the output voltage and large power loss. Therefore, a single stage multilevel converter based on transformer multi-tap voltages control fed by a low DC voltage source (MCMTVC) is proposed in this paper. The converter achieves multi levels by control different transformer tap voltages through the power switches connected to the taps, and the number of output levels can be conveniently expanded through the expansion of the transformer taps. During operation, the power switch branches that each branch is connected in series by at most two power transistors including power diodes take turns to serve power exchange, and the voltage stress upon the power switches active in PWM state is very low. The principle of the converter is described in this paper in the first, and then the corresponding control method is put forward, furthermore the characteristics of the converter are discussed. In final, A 9-level simulation platform with the mentioned topology and control strategy using the MATLAB / Simulink software is established, and then simulation research is carried out, whose results have verified the proposed control strategy and conclusions.