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Objectives: Chronic hepatitis C (CHC) is a major health problem in Egypt with about 9.8% of Egyptian population having an active hepatitis C infection. Almost Every step in the Hepatitis C virus (HCV) life cycle is closely related to lipid metabolism. HCV circulate in the body in lipid-rich particle, attach to hepatocytes via lipoprotein receptors. Recent attention focused on HMG CoA Reductase inhibitors (statins) and their potential therapeutic role in hepatitis C. Methods: This retrospective closed cohort study included 60 naive CHC patients. The HCV statins group patients (n = 26) received the combination of Standard of care (Interferon alfa and repavirin) and fluvastatin 80 mg daily; HCV non statins group (n = 43) treated with the SOC treatment only. Both groups receive their treatment over a duration of 48 weeks. Results: On-treatment viral responses as well as the SVR were significantly better in HCV statins group in comparison to HCV non statins group; rapid virological response (RVR), early virological response (EVR) and sustained virological response (SVR) were (13.3%, 73.3% and 68.3%) in HCV statins group vs. (0%, 58.8% and 52.9%) HCV non statins group with p value 0.00, 0.003 and 0.003 respectively. Multivariate logistic regression model identified statins use as a significant predictor of an SVR. Conclusion: A combination of fluvastatin and SOC significantly improved the SVR in naive CHC Egyptian patients. Further powered randomized control trails are needed to elucidate statins role in HCV treatment.

Milk production and reproductive performance can decrease as a result of hyperketonemia in lactating dairy cows. In addition, cows with hyperketonemia are at higher risk of developing a variety of diseases including displaced abomasum, metritis, retained placenta, and clinical ketosis, and are more likely to be culled. The negative impact of hyperketonemia can be observed at both the individual-cow and herd levels. As a result, significant economic losses might be encountered in dairy herds with a high incidence of hyperketonemia., American Association of Bovine Practitioners Proceedings of the Annual Conference, 2013