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Syntaxin 4 (STX4), a plasma membrane-localized SNARE protein, regulates human islet β-cell insulin secretion and preservation of β-cell mass. We found that human type 1 diabetic (T1D) and non-obese diabetic (NOD) mouse islets show reduced β-cell STX4 expression, consistent with decreased STX4 expression as a potential driver of T1D phenotypes. To test this hypothesis, we generated inducible β-cell-specific STX4-expressing NOD mice (NOD-iβSTX4). Of NOD-iβSTX4 mice, 73% had sustained normoglycemia versus + Treg cells were also enriched in NOD-iβSTX4 islets. These results provide a deeper mechanistic understanding of STX4 function in β-cell protection and warrant further investigation of STX4 enrichment as a strategy to reverse or prevent T1D in humans or protect β-cell grafts.

Objective The present study aimed to investigate the impact of ulinastatin (UTI) on sigma-1 receptor (σ1R) and bind to immunoglobulin protein (Bip) after cerebral ischemia/reperfusion (I/R) injury. Methods The middle cerebral artery occlusion (MCAO) model was used to induce cerebral I/R injury. A total of 80 male SD rats were randomly divided into six groups: Control, MCAO, MCAO+50,000 U/kg UTI (U5), MCAO+100,000 U/kg UTI (U10), MCAO+200,000 U/kg UTI (U20), MCAO+300,000 U/kg UTI (U30). At 24 and 48 h after MCAO, the infarct volume, neurological dysfunction, and grip strength test were measured, and the level of σ1R and Bip proteins was further detected using Western blot. The molecular docking assays were carried out to verify the interaction between σ1R, Bip, and UTI. The serum concentration of Bip as well as the binding assay between σ1R, Bip, and UTI were determined using enzyme-linked immunosorbent assay (ELISA). Results UTI increased the modified neurological severity score and upregulated the σ1R and Bip expression in the cerebral cortex under MCAO state. The grip strength of forelimbs increased significantly in the U20 and U30 groups compared to that of MCAO rats, while the Bip serum levels remained unchanged. The molecular docking assay indicated a putative binding between σ1R, Bip, and UTI. The binding assay also revealed that both σ1R and Bip could be combined with UTI. Conclusions UTI displays a neuroprotective effect via upregulation of σ1R and Bip during I/R injury, suggesting that UTI modulate σ1R and Bip and their interaction may provide a novel insight into the potential therapeutic mechanisms of stroke.

Background The effect of microRNAs (miRNA) on cancer regulations has received a considerable amount of attention recently. MiR-133a-5p has been identified as an anti-tumor miRNA in several types of cancers. However, the effect of miR-133a-5p on gastric cancer (GC) have not been uncovered. In this study, we sought to evaluate the regulation of TCF4 expression by miR-133-5p and the role of the miR-25-3p/TCF4 axis in the progression of GC, with the aim of identifying a potential therapeutic target for GC. Methods TCGA (The Cancer Genome Atlas), GTEx (The Genotype-Tissue Expression) and GEO (Gene Expression Omnibus) database were used to analyze the expression and prognosis. We performed MTT and EdU assays to elucidate the effect on cell replication. Apoptotic cells were stained with annexin V-fluorescein isothiocyanate and propidium iodide to stain, and then analyzed by flow cytometry. The effect on cell metastasis was investigated in wound healing and transwell assays. A dual-luciferase reporter assay was used to check for the direct targeting of TCF4 by miR-133a-5p. Bioinformatic analysis of the relationship of TCF4 with tumor microenvironment and the signaling cascade of TCF4 was finally performed. Results We found that the level of miR-133a-5p was decreased in both tumor tissues and GC cell lines. MiR-133a-5p inhibited cell growth and metastasis, but promoted cell apoptosis. MiR-133a-5p directly targeted TCF4 and downregulated its expression. TCF4 was highly expressed in tumor and higher level of TCF4 indicated poorer prognosis. Moreover, TCF4 overexpression reversed the aforementioned anti-tumor activity of miR-133a-5p. The expression level of TCF4 was significantly correlated with tumor-infiltrating immune cells. Conclusions Our findings altogether reveal that miR-133a-5p can serve as a tumor suppressor in gastric cancer via the miR-133a-5p/TCF4 pathway.

BACKGROUND: Thrombospondins (THBSs) are glycoproteins expressed in the extracellular matrix (ECM) and have critical roles in tumor development and metastasis. However, the diverse expression patterns and prognostic roles of distinct THBS genes in gastric cancer have not been fully elucidated. In the current study, we aimed to investigate the expression patterns of THBSs in gastric cancer (GC) and determine whether they are prognostic markers for this malignancy. METHODS: mRNA expression status and genetic mutations of THBS family members were performed by using ONCOMINE, UCSC Xena browser, GEPIA, and cBioPortal databases. Prognostic values and function enrichment analysis of the members were assessed via Kaplan-Meier plotter and Metascape. RESULTS: we found that the mRNA expression of THBS1, THBS2, THBS4, and COMP were higher in patients with GC tissues than those in normal gastric mucosa and there was no difference in the mRNA expression of THBS3 between GC and normal tissue. Survival analysis revealed that mRNA levels of THBSs were strongly related to worse OS in GC patients (P

Background CIBMTR audits take place every four years and the University of Maryland Greenebaum Comprehensive Cancer Center, BMT Department has consistently met required thresholds. However, this changed with the 2018 audit when the overall error rate was 3.3%; above the threshold of 3%. The deficiencies identified during the audit necessitated the implementation of strategies to improve data accuracy. Method The CIBMTR audit results identified three key deficient reporting areas. These included: Method of Disease Assessment (specifically cytogenetics), Disease Status, and Acute and Chronic Graft vs Host Disease (aGVHD) (cGVHD). Strategies were developed to address these specific deficiencies. Results First, regularly scheduled meetings with the BMT physicians to review complex, difficult cases/questions/scenarios were instituted. These meetings may include reviewing method of disease assessment in which the DM may be having difficulty extracting the information from a variety of reports; Disease assessment questions for a variety of oncological diseases are often-complicated; a review from the physician to validate reported data is crucial. Identifying the diagnosis date and maximum grade of aGVHD and cGVHD are especially challenging, and are verified with the provider. Second, in May 2019, EMR templates for key documentation requirements were implemented. These templates include the required necessary information for diagnosis dates and grading of both aGVHD and cGVHD, and disease assessment with respect to hematologic, molecular, and radiologic interpretation and are completed by the physician. Third, the number of Internal Assessment (IA) forms audited by the DMs on a monthly basis has increased to a total of 24 forms per month, a 14% increase. This increase in the number of forms audited increases the number of data points examined for accuracy. In addition, auditing practice has changed in that the same patients are reviewed over time. The BMT program manager reviews the forms at a monthly audit review meeting. If there are errors, the correction(s) is/are made into FormsNet3. If error trends are identified a CAPA is implemented with the guidance of the Quality Manager. The BMT team also increased the acceptable audit results from 97%-100% to 98%-100%. Conclusion These three strategies are key to achieving the desired result of greater than 98% accuracy rate on completed, submitted CIBMTR forms. The communication meetings with the physicians have broken down the barriers between physicians and DMs and brought everyone to work together toward a common goal. The EMR templates provide a tool for the physicians to document the essential data required. Finally, adding additional IA forms to be audited will provide additional checks for data accuracy. As a result of these strategies, achieving a goal of 98%-100% data accuracy for submitted CIBMTR forms is feasible.

With the rapid demand for underwater optical communication (UOC), studies of UOC degradation by oceanic turbulence have attached increasing attention worldwide and become a research hot-spot in recent years. Previous studies used a simplified and inaccurate oceanic turbulence spectrum, in which the eddy diffusivity ratio between temperature and salinity is assumed to be unity and the outer scale of turbulence is assumed to be infinite. However, both assumptions are not true in most of the actual marine environments. In this paper, based on the Rytov theory in weak turbulence, we derive analytical expressions of “the aperture-averaged scintillation index” (SI) for both plane and spherical waves, which can clearly demonstrate how SI is influenced by several key factors in UOC. Then, typical fade statistics of the UOC system in weak turbulence is discussed including the probability of fade, the expected number of fades per time, the mean fade time, signal-to-noise ratio and bit error rate. Our results show that spherical wave is preferable in the UOC system in weak turbulence compared to plane wave, and the aperture-averaged effect has a significant impact on UOC system’s performance. Our results can be used to determine those key parameters for designing the UOC system over reasonable ranges.

Die-to-die interconnects linking multiple functional dies in a modern 3-D or 2.5-D IC by micro-bumps could experience resistance increase after certain time of field operation due to parametric defects or aging. To cope with this reliability threat, we present an “on-line transition-time binning method” that aims to continuously detect excessive transition time occurring at a target die-to-die interconnect. Our method attaches a monitor to the termination end of each target interconnect. Any transition (rising or falling) is converted into a pulse-width first, which is then further compared to a dynamically tunable threshold for a binary pass/fail judgment. By multiple runs of transition-time monitoring while sweeping the threshold incrementally, the “transition-time bin” of each target interconnect can be derived and thereby a timing failure threat can be detected by a monitor center before it actually strikes.

Background As the workload for completing CIBMTR forms continues to increase, the resources required to complete them has not increased at the same pace. While CPI goals are met at the University of Maryland Marlene and Stewart Greenebaum Comprehensive Cancer Center (UMGCCC), because of resource limitations, achieving CPI is a constant struggle. When CIBMTR announced that the completion of Cellular Therapy forms were highly recommended, how to accurately and timely completion of CPI forms has become our top priority. Method The simplest solution to the problem would be to add resources by hiring an additional Data Manager. However, with the scarcity of knowledgeable resources available, hiring and training a new Data Manager is a challenge. Therefore, with the number of Data Managers at our center, we identified the following strategies to implement to maximize time and effort while maintaining quality and accuracy in completing CIBMTR forms. The first thing we identified was to extract from FormsNet 3 all the forms due for the current CPI period into an excel spreadsheet, and divided the workload up by transplant type. Next, we determined how many forms each Data Manager needed to complete per day to be able to achieve CPI for the reporting period. To ensure we achieved our set goal, we created measures to evaluate progress of form completion. Data Managers provide a biweekly report to the manager, summarizing what was accomplished in the prior two weeks. From the report, Data Managers can determine whether or not they accomplish their set goals and modify accordingly. Furthermore, CIBMTR provides a CPI summary sheet to each center on a weekly basis indicating the current CPI completion percentage with a tool that identifies progress toward CPI goals. In addition, to assist in verifying data accuracy, the Data Managers incorporated internal assessments between Data Managers as well as meeting with primary physicians to discuss and confirm that certain complex data was accurately reported to CIBMTR. Result CPI requirements were met, however, real-time reporting on patients receiving transplant and cell therapy has not been possible. Conclusion While CPI reporting requirements are met, we anticipate that by developing realistic, achievable methods to 1) increase the number of forms completed per day; 2) create a tool to accurately determine the number of forms and which forms are coming due in real time; and 3) create a schedule of additional tasks required of the Data Manager, forms will be completed as transplant and cell therapies are being conducted.

Background Medical data has long been generated and shared. Today, not only do healthcare analytics assist us in understanding past performance, but is also used to obtain insight into what may occur in the future. Healthcare analytics has become essential, achievable, and unavoidable. The Blood and Marrow Transplant (BMT) department at one Comprehensive Cancer Center has firsthand experience with a variety of healthcare software and informatics programs. In 2015, a team from the organization reported the process of choosing the best match for BMT informatics software. At present, the BMT department has set out to use a new hospital software program, "Software M", which helps hospitals use patient-oriented data to manage, measure and monitor quality, patient safety, financial and clinical outcomes. [1] The BMT data managers (DM), along with the BMT Program Manager, have taken advantage of this software's quality performance aspect to improve their CIBMTR data accuracy rate. Method Internal assessments (IA) were completed and audited by the DM for validity and quality of registry data. After auditing the IA forms, the DM entered monthly IA through "Software M". In the past, calculating results proved laborious. Now, calculating the accuracy rate of CIBMTR data has become much more efficient. Using the software has improved DM efficiency and leaves less room for data entry error. To enhance output of the report, the DM provided a variety of IA forms to a healthcare analyst at the hospital. According to CIBMTR criteria, the DM distinguished which IA form fields were critical fields versus random fields. Data could now be displayed through a variety of visual representations, the DM reviewed the output requirements with the analyst. Results Identified output resulted in the following: Total number (No.) of questions (QNS) correct; total No. of QNS answered; percent success overall; total No. of critical QNS answered; total No. of correct critical QNS; percentage success of critical QNS; total No. of non-critical QNS correct; total No. of non-critical QNS answered; percentage success of non-critical QNS. In addition, a graph with the overall, critical, and random percentages is displayed. After the use of "Software M", the analysis of the accuracy rate has become significantly more precise and descriptive. CONCLUSION Healthcare analytics is making data more accessible than ever. Over the past four years, the BMT department has made advances with state-of-the-art technology. Trends of the data accuracy rates of IA can be viewed at a glance and if need be, corrected in a more timely manner, improving overall outcomes and allowing for a thorough training for staff. With CIBMTR and FACT standards becoming increasingly stringent, better strategies for timely data analysis are key.

A faulty interposer in a 2.5-D integrated circuit often results in a hefty loss as the potentially expensive known-good-dies bonded on the interposer will have to be discarded as well. To avoid such a last-minute loss during a multichip integration process, built-in self-repair (BISR) is highly valuable. Even though there have been many BISR schemes in the literature, the proposed method offers a number of distinct features. First, it can target not only catastrophic faults, but also timing faults. Second, it can be applied to general multi-pin interconnects and it can be applied to repair an interposer with multiple faulty interconnects. Third, it can perform the test-and-then-repair flow on-the-fly, and thereby eliminating the overhead of extra repair storage incurred in previous methods.

By exploiting communication temporal and spatial locality represented in actual applications, the paper proposes a locality-route pre-configuration mechanism (i.e. LRPC) on top of the Pseudo-Circuit scheme, to further accelerate network performance. Under the original Pseudo-circuit scheme, LRPC attempts to preconfigure another sharable crossbar connection at each input port within a single router when the pseudo circuit is invalid currently, so as to produce more available sharable route for packets transfer, and hence to enhance the reusability of the sharable route as well as communication performance. Our evaluation results using a cycle-accurate network simulator with traces from Splash-2 Benchmark show 5.4% and 31.6% improvement in overall network performance compared to Pseudo-Circuit and BASE_LR_SPC routers, respectively. Evaluated with synthetic workload traffic, at most 10.91% and 33.72% performance improvement can be achieved by the LRPC router under the Uniform-random, Bit-complement and Transpose traffic as compared to Pseudo-Circuit and BASE_LR_SPC routers.

A flow integrating instrument based on the diaphragm gas meter is designed with MSP430 microprocessor. The double reed switch is used for the flow signal acquisition with higher Accuracy. In order to reduce the influence of pressure and temperature on gas flow measurement, the PT1000 resistance temperature sensor and silicon piezo-resistive pressure sensor circuit are designed. The embedded software is developed with C. The experimental result show the flow integrating instrument has high accuracy.

There is a wide application for the string-net structure in the areas of architecture and spaceflight. In the area of spaceflight, the string-net structure is mainly used in the deployable antenna. The three-dimensional string-net structure is a kind of typical string-net structures applied on the deployable antenna. Here the string-net structure is analyzed. At first, composition of the string-net structure is presented. Then the dynamical relaxation method is used to obtain the solution for movement of the structure after its instability. At last, using numerical simulation, tensions in the strings are computed. It is proved finally that the three-dimensional string-net structure still possesses the capability of keeping its shape and stiffness after its instability.

This paper investigates the impact of additives and cooling way on the metallization rate of reduction product by the experiment of the coal-based direct reduction of vanadium titanomagnetite ; The promotion of direct reduction product metallization by additive species, additive content, reduction time and cooling way was studied and the optimal condition was found; when used 3% CaF2 as additive reduced for 0.5h and used water quenching to cool down the product, finally got the product which metallization got 93.80% and 42.93% higher than the null sample.

Since Lubuge hydropower station began to introduce the project management system, it has been greatly contributed to the efficiency of domestic hydropower project management. But the traditional and extensive management method is usually used at present. With the rapid development of computer technology, information technology, network and communications technology and their widely application in the information management for hydropower construcion, the information management process of hydropower project is significantly accelerated. From the gridding management theory in urban management system, based on the traditional management means, the concept and principle of gridding management theory is introduced and applied in the management for hydropower construcion, in which all items of hydropower project are worked as research subjects with the contract as a link so that the management level is more meticulous and the management objects are more precise. The whole spatial grid of hydropower construction is subdivided into a grid-based unit as the smallest unit and the method of full information is used to complete the refined management of grid units with their various attributes such as contract attribute, progress properties, investment properties, cost attributes, security attributes. The purpose is to achieve a refinement of construction management for hydropower project by means of grid-based meticulous management.

In order to improve the comprehensive mechanical properties of the steel, the heat treatment software COSMAP is used to simulate the rolling and controlled cooling of I-beam. The numerical simulation shows that: when the cooling rate is controlled at 10 °C/s around, the mechanical properties of controlled cooling can be obviously improved. The strength and hardness can be improved on the condition of ductility and toughness ensured, while the amount of residual austenite can be reduced significantly, which provide a theoretical basis for further optimization of the heat treatment process.

In order to improve the comprehensive mechanical properties of the steel, the heat treatment software COSMAP is used to simulate the rolling and controlled cooling of H-beam. The numerical simulation shows that the mechanical properties of controlled cooling can be obviously improved, when the cooling rate is controlled at 10°C/s around. Strength and hardness can be improved under the condition of ductility and toughness ensured. Meanwhile the amount of residual austenite can be reduced significantly. It provides a theoretical basis for further optimization of the heat treatment process.

In this paper, a finite element model with respect to actual state of micro-cutting is established by adopting software of ABAQUS/Explicit. Based on the FE model, the cutting force and specific cutting force with various uncut depth of cut with different cutting edge radius are compared and then analyzed with regard to this simulation. In micro-cutting, the nonlinear scaling phenomenon is more evident with the decreasing of uncut chip thickness. The likely explanations for the size effect in small uncut chip thickness are discussed in this paper.

Most agricultural machines cultivating in greenhouse use diesel engine or gasoline engine as the prime mover, they can make pollutions to crops and their growing environment easily with the emissions, lead, dust and other harmful substances at work, at the same time, most of them exit the problems of inconvenient to operate, labor intensity and big noise etc. To solve these problems, a kind of new miniature remote controlled led electric tractor was proposed in this paper, which is suitable for the plow work in greenhouse. Besides, this paper also researched into the spatial layout of this machine and built the 3-D model, the main parts of this machine’s electric driving system and the calculation of their parameters were finished. Based on these, a prototype was made, and preliminary road and field tests were did. The results showed that the prototype can complete normal remote plow work, simultaneously with the advantages of low carbon environmental protection, low operating costs, easy operation and low noise.

The mechanism of micro-milling modeling for aluminum alloy 7050-T745 is to be investigated, and a finite element model for micro-milling that reflects the actual state of the three-dimensional micro-milling is built by adopting the software of ABAQUS/Explicit. Experiment is conducted to verify the validation of the model. Simulated chip morphology in different cutting parameters agrees to the experimental results very well. Based on the FE model, cutting stresses, equivalent plastic strains, temperatures distribution and cutting forces are obtained and analyzed. This provides a good method to investigate the micro milling principles.

The electromagnetic environment of laneways in underground coal mines is an important area for the design of new electronic products, as well as a fundamental space for mine monitoring, surveillance, communications and control systems. An investigation of electromagnetic interference in coal mines is essential for the enhancement of performances of these systems. In this study, a new field method is provided in which radiated emission tests in coal mine laneways have been carried out. We conclude that: 1) the wiring motor vehicles can radiate interference with a bandwidth up to 1 GHz and with an amplitude 10 dBμV/m higher than the background noise; 2) the PHS (Personal Handy phone System) mobile communication system can cause interference 40 dBμV/m higher than the background noise; 3) an interference 25 dBμV/m higher than the background noise can be generated during the communication at a working bandwidth of 48.8 MHz; and 4) power cables, battery vehicles as well as mechanical and electrical dong rooms have little effect on the electromagnetic radiation environment in coal mine tunnels.

It is very important to accurately recognize and locate pulverized and block coal seen in a coal mine's infrared image monitoring system. Infrared monitor images of pulverized and block coal were sampled in the roadway of a coal mine. Texture statistics from the grey level dependence matrix were selected as the criterion for classification. The distributions of the texture statistics were calculated and analysed. A normalizing function was added to the front end of the BP network with one hidden layer. An additional classification layer is joined behind the linear layer. The recognition of pulverized from block coal images was tested using the improved BP network. The results of the experiment show that texture variables from the grey level dependence matrix can act as recognizable features of the image. The innovative improved BP network can then recognize the pulverized and block coal images.

In order to provide a theoretical basis for methane sensor placement in the vertical direction of a tunnel, the software Fluent was used to simulate methane distribution. A geometric roadway model was established and divided by grids. Methane distribution in both level and vertical sections was simulated using a realizable k-ɛ model with the Fluent software according to a conservation equation in a turbulent state, a turbulent kinetic energy equation and a turbulent dissipation rate equation. The realizable k-ɛ model and the Fluent software were used to simulate methane distribution according to the principle of the conservation equation in a state of turbulent flow. The results show that after overflowing, a methane level with a certain thickness is formed. Methane density curves at three specific levels were internally consistent and methane density at higher levels is denser than that at lower levels. Methane distribution becomes thinner in the direction of wind and methane in the vertical direction becomes uniform if wind speed is high. The distance between sensors and roof should be less than 300 mm which is in agreement with mine safety regulations.

The fixed clamp should be installed inside the BOP stack for sectional blockage and tubing pulling job. When there is combined string in downhole, it causes inconvenience in replacing slips of different specifications because of pressure in BOP stack. To solve the problems mentioned above, variable diameter slip was invented. Different arc's central angle model of slip was set by ANSYS, the oil tube was divided by sweep while the slip was divided randomly. The analysis shows the arc's central angle for clamping o73 oil tube is 106°and the clamping force meets operation needs and the design requirements.

The elevator being used in field application causes several problems such as low level of mechanization and high intensity of labor. Therefore, electromotion elevator is developed and tested in this paper, which works with mechanized workover equipments. On the base of traditional elevator, the safety pin for the rings is driven by a spring and its own gravity, while the door of the elevator, with self-locking function, is driven by a DC motor which is remotely controlled. Through the field test and application, the electromotion elevator shows desirable safety, reliability and continuous working ability, which satisfy the requirement of workover operation. Introduction Elevator is one of the commonly used tools for lifting and lowering oilfield tubular out of, or into an oil, gas or geothermal well. In hoisting a joint of tubular, the elevators are latched onto the pipe below the tool joint which prevents the pipe from slipping through the elevators. In the process of workover operation, the movement of the elevator, the opening and closing of the elevator door and the safety pin were manually finished, which leaded to high labor intensity, complex procedure and some security risks. As the oil and gas exploitation in some oil field comes to the late stage, workover operation frequency increased greatly, and the disadvantages of traditional elevators have become increasingly prominent. The elevators driven by hydraulic power have been produced by the famous petroleum equipment manufacturers such as National Oilwell Varco (BX series) and Blohmand Voss Repair GmbH. Typically the hydraulic elevators were hinged to the hook with a hydraulic pipeline and the workers operated the elevator in the distance. However, because of the existence of hydraulic pipeline, the elevator could not be taken turns and the working radius was quite limited. In additional, the hydraulic elevators were usually of big size and weight, which was more suitable for drilling and completion but the workover process. In this paper, an electromotion elevator is designed, optimized and tested in field application. Structure and Working Principle Using a traditional elevator body, the electromotion elevator has four newly designed parts, named motor driven door, safety pin, and waterproof cover, respectively. Motor driven door. The motor driven door comprises a DC motor, a worm-gear reducer, transmission gears, a door with gear teeth and battery, as shown in Fig. 1. The door could be rotated by the motor to close or unclose the hatch of the elevator body. There are three advantages in using a worm-gear shape reducer: transmitting the rotary motion from the motor to the door, increasing the driving torque and locking the door to prevent the tube from slipping through the elevator taking advantage of the function of anti-directional self-locking. International Conference on Intelligent Systems Research and Mechatronics Engineering (ISRME 2015) © 2015. The authors Published by Atlantis Press 2167 Fig. 1 Schematic diagram of motor driven door The opening and closing of the door depends on the forward and reverse rotation of the DC motor and the motor is controlled by the electrical control system. The electrical control system comprises electromagnetic relay switches and distance controller. The work radius of the controller is more than 30 meters. Safety pin. There is one safety pin hole in each hanger arm, and the hole is rectangular and symmetrical to the central axis. The safety pins are of “U” shape and are installed in the holes together with a compression spring. One end of the spring is fixed to the elevator body and the other end is fixed to the pin. When the elevator is put on the wellhead platform, the end A of the safety pin will get in touch with the plane and the spring will be compressed by the gravity of the elevator body, as a result the end B of the pin will retract into the hanger arm to make room for the insertion and removal of the elevator bail. Once the elevator is hoisted by the elevator bail, the end A of the pin will be pulled out under the action of the elastic force of the spring, meanwhile the end B of the pin approach the bottom of the gap of the hanger arm. Then the bails are entrapped and cannot fall off the elevator. Fig. 2 Schematic diagram of safety pin Waterproof cover. The well fluid generated by overflow an extrusion contains water and oil which may do great harm, such as corrosion and short circuit. By the field test, the water entering into the electric control system may by splashing to the elevator directly or through the opening of the elevator crescent. So the waterproofing ability of all the motor and other electrical components must reach level IP-4 to prevent the water resulting in the short circuit faults. A lot of Cl,S and etc. ions due to the high salinity underground, so the above electrical components can be corroded by the well fluid. Therefore the electrical system of the crescent should be sealed further. The sealing device is showed in the Fig. 3. In which the motor and battery are placed in a whole metal shell, and the shell and the rear cover form the complete sealing region A by the rubber strip to prevent the water splashing into the electrical system.

Through Silicon Vias (TSVs) are known to be susceptible to various thermal-mechanical and electro-migration effects that could lead to unexpected resistance increase after certain time of field operation. To cope with this reliability threat, we present an on-line monitoring method that aims to continuously detect excessive transition time occurring to a TSV (which often indicates performance degradation). Our method attaches a monitor to the termination end of a TSV. Any transition there is converted into a pulse-width, which is further compared to a dynamically tunable threshold. A Timing Failure Threat (TFT) is thereby detected when the pulse-width exceeds the threshold. This method can be applied to a large number of TSVs easily since the monitoring results are binary and can be stored in FFs forming a scan chain for easy access.

Interposer is a critical component in a 2.5-D IC as it serves as a common platform upon which multiple known good dies are bonded. Any defect in an interposer will lead to a loss of compound yield. To avoid such a last-minute yield loss, we propose a timing-aware Built-In Self-Repair method to increase the fault tolerance of high-speed interposer wires. The most unique feature of our method as compared to previous works is that ours can repair not only catastrophic faults, but also timing faults. We present an on-the-fly test-and-repair flow that can seamlessly link Pulse-Vanishing Test, a previous timing-aware interconnect test method, with a popular redundancy structure.

In this paper, a mixed finite element formulation based on Reissner-Mindlin plate theory is applied for the free vibration analysis of linear elastic plates. A four-node quadrilateral element, Q4BL, recently developed by Zienkiewicz et al. [Linked interpolation for Reissner-Mindlin plate elements Part I. Int. J. Numer. Methods Engng (36, 3043–3056 (1993).] using linked interpolation to couple transverse displacement and rotation degrees of freedom, is numerically tested. Numerical examples indicate that the application of such a mixed formulation to dynamic problems is convenient and the element Q4BL is efficient and reliable for both thick and thin plates.

A new type of microwave electrodeless lamp (MWL) is introduced. During the experiment, conventional Hg lamp and MWL are used as light sources; the main performance indexes of the two kinds of lamps are identified. The results indicated that microwave electrodeless lamp can provide microwave, ultraviolet light and produce higher-concentration ozone at the same time. The light intensity of the ultraviolet light (UV) at 254nm produced by MWL was about 20 times more than traditional ultraviolet lamp. The concentration of ozone produced by microwave electrodeless lamp irradiation was about the one-tenth of the ozone machine.

We report a novel measurement technique for the wide‐band determination of the frequency response of photodetectors. It is based upon the accurate measurement of the photocurrent noise spectra under illumination with a light‐emitting diode. The high sensitivity of −200 dBm/Hz within a frequency regime from 10 MHz to 1.6 GHz renders it particularly attractive for investigating the response behavior at low optical input levels and for characterizing frequency‐dependent gain phenomena. The practical potential of the method is illustrated by applying it to various types of InGaAs‐based photodetectors (p‐i‐n and avalanche photodiodes and metal‐semiconductor‐metal photodetectors).

A dynamical model for autonomous mobile intelligent robots is presented. Based on the local information of the swarm, a fuzzy logical controller (FLC) of the attraction/ repulsion function is built. Combining with the rate consensus algorithm, the swarming of the separation, cohesion and alignment is achieved. Based on the optimal controller theories, a performance target is used to measure the states of the system. By applying the connected network from the individual local perceived information, the aggregation of the multi-agent systems can swarm following a whole consensus in the computer simulation.

An approach of curvature view based is presented for skull surface feature representation and recognition. The curvature information of skull surface is transformed into curvature color image, then the image projection used as skull feature is constructed by Radon transformation from many orientation, finally wavelet function is applied to decompose the skull projection signal. Experiment show that this method is effective between tiny different skull shape.

The electromagnetic environment of the substations in mine suffers serious contamination. There are a lot of electromagnetic interferences in mine. The Electrical Fast Transient/burst (EFT) is a fast uprising, short-time, low-energy and repetitive pulse high group, which lias significant influence on monitoring system of mine safety. The concept of EFT is introduced in this paper. The hazards of EFT interference on monitoring system of mine safety are analyzed. Meantime, the hazard' s countermeasures of EFT interference on monitoring system of mine safety are analyzed. For design of monitoring system of mine safety, the countermeasures of EFT interference are very effective.

AIM: To investigate the damaging effect of high-intensity focused ultrasound (HIFU) on cancer cells and the inhibitory effect on tumor growth. METHODS: Murine H22 hepatic cancer cells were treated with HIFU at the same intensity for different lengths of time and at different intensities for the same length of time in vitro, the dead cancer cells were determined by trypan blue staining. Two groups of cancer cells treated with HIFU at the lowest and highest intensity were inoculated into mice. Tumor masses were removed and weighed after 2 wk, tumor growth in each group was confirmed pathologically. RESULTS: The death rate of cancer cells treated with HIFU at 1 000 W/cm2 for 0.5, 1, 2, 4, 8, and 12s was 3.11±1.21%, 13.37±2.56%, 38.84±3.68%, 47.22±5.76%, 87.55±7.32%, and 94.33±8.11%, respectively. A positive relationship between the death rates of cancer cells and the length of HIFU treatment time was found (r = 0.96, P

This paper describes the state-of-the art of the research work on the mainland of China pertaining to the prestressed concrete reactor vessel and to nuclear reactor containment. The results of tests of 1 10 th scale model of a PCRV and its deep end slab are presented. The 3D linear and nonlinear stress analyses and ultimate load of these models are also described. A new type of containment, a steel-plate-concrete composite containment, is proposed and evaluated. At last, a survey of the Qin Shan Nuclear Power Plant is described.

The structural effects of heating 1500 A Au/GaAs (001) encapsulated with 2000 A of SiO2 were examined by scanning electron microscopy and X-ray diffraction. It was observed that SiO2/Au/GaAs (capped) in vacuum up to 500°C remained shiny and gold in color, whereas similar heating of Au/GaAs (uncapped) caused a change of color from shiny gold to dull silver. Furthermore, mass spectroscopy showed that the amount of arsenic vapor evolved was much less for the capped sample. However, X-ray diffraction showed that Au7Ga2 formed abundantly in both types of samples after heating at 500°C, though the epitaxial relationship was mainly Au7Ga2 (001) ‖ GaAs (001) for capped and Au7Ga2 (100) ‖ GaAs (001) for uncapped. SEM revealed gold-rich aligned rectangular protrusions on the surfaces of SiO2/Au/GaAs as well as Au/GaAs after heating at 500°C, though the average length of these rectangles was 1.5 μm for the capped sample and 6.7 μm for the uncapped sample. Moreover, new morphological features absent in Au/GaAs were observed in SiO2/Au/GaAs. These features are a gold-rich maze with a line width of μm and gold-rich protruded lines with a line width of 9 μm. The gold-rich protruded lines were formed by the growth and joining together of some gold-rich aligned rectangular protrusions. The gold-rich maze was observed in SiO2/Au/GaAs after heating in vacuum, but was not observed in SiO2/Au/GaAs after heating in nitrogen.

In this paper, a novel system of electrical current induced liquid phase epitaxial apparatus is presented. Electroepitaxial growths of Ga,-xAlxAs on thin GaAs substrate were carried out at constant temperature with a dc current as the sole driving force. Constant composition Ga1−xAlxAs electroepilayers with mirror-smooth surfaces were obtained. The average rate of epitaxial growth in the system is linearly proportional to the current level passed through the substrate-melt interface. In particular, a new technique of obtaining Ga1−xAlxAs:Si p-n junctions at constant temperatures is presented for the first time: the “step-current” technique.