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1. Italian patients with hemoglobinopathies exhibit a 5-fold increase in age-standardized lethality due to SARS-CoV-2 infection

Author: Sabrina Quintino, Filomena Longo, Maurizio Miano, Vincenzo Voi, Maria Caterina Putti, Margerita Migone De Amicis, Monica Fortini, Susanna Barella, Barbara Gianesin, Federico Bonetti, Andrea Beccaria, Manuela Balocco, Andrea Piolatto, Saveria Campisi, Rosamaria Rosso, Angelantonio Vitucci, Valentina Carrai, Alessandra Quota, Zelia Borsellino, Antonio Piga, Maddalena Casale, Anna Rita Denotti, Michela Ribersani, Maria Rita Gamberini, Domenico Roberti, Alberto Piperno, Roberto Lisi, Carmelo Fidone, Maria Domenica Cappellini, Sabrina Bagnato, Anna De Giovanni, Micol Quaresima, Valeria Maria, Lorella Pitrolo, Marco Marziali, Giovanna Graziadei, Carmen Gaglioti, Aldo Filosa, Chiara Dal Zotto, Lucia De Franceschi, Irene Motta, Immacolata Tartaglione, Francesco Arcioni, Aurelio Maggio, Marilena Serra, Giovan Battista Ruffo, Massimo Gentile, Elisa De Michele, Anna Spasiano, Paolo Ricchi, Antonella Massa, Silverio Perrotta, R. Mariani, Gian Luca Forni, Longo, Filomena, Gianesin, Barbara, Voi, Vincenzo, Motta, Irene, Pinto, Valeria Maria, Piolatto, Andrea, Spasiano, Anna, Ruffo, Giovan Battista, Gamberini, Maria Rita, Barella, Susanna, Mariani, Raffaella, Fidone, Carmelo, Rosso, Rosamaria, Casale, Maddalena, Roberti, Domenico, Dal Zotto, Chiara, Vitucci, Angelantonio, Bonetti, Federico, Pitrolo, Lorella, Quaresima, Micol, Ribersani, Michela, Quota, Alessandra, Arcioni, Francesco, Campisi, Saveria, Massa, Antonella, De Michele, Elisa, Lisi, Roberto, Miano, Maurizio, Bagnato, Sabrina, Gentile, Massimo, Carrai, Valentina, Putti, Maria Caterina, Serra, Marilena, Gaglioti, Carmen, Migone De Amicis, Margerita, Graziadei, Giovanna, De Giovanni, Anna, Ricchi, Paolo, Balocco, Manuela, Quintino, Sabrina, Borsellino, Zelia, Fortini, Monica, Denotti, Anna Rita, Tartaglione, Immacolata, Beccaria, Andrea, Marziali, Marco, Maggio, Aurelio, Perrotta, Silverio, Piperno, Alberto, Filosa, Aldo, Cappellini, Maria Domenica, De Franceschi, Lucia, Piga, Antonio, and Forni, Gian Luca
Subjects: Sars-CoV-2, business.industry, Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), Sars-CoV-2, hemoglobinopathies, Medicine, hemoglobinopathies,SARS-CoV-2 infection, Lethality, Hematology, hemoglobinopathies, business, Virology
Published: 2022

2. Caring for nursing home residents with COVID-19: a 'hospital-at-nursing home' intermediate care intervention

Author: Giancarlo Landini, Guglielmo Bonaccorsi, Cecilia Piga, Letizia Martella, Paolo Carrai, Eleonora Barghini, L. Baggiani, Enrico Mossello, Riccardo Barucci, Giulia Bulli, Lorenzo Stacchini, Enrico Benvenuti, Simone Pupo, Gabriele Vaccaro, Sante Giardini, Giulia Rivasi, Claudia Cosma, Andrea Crociani, Serena Boni, M. Bulgaresi, Giulia Bandini, Irene Marozzi, Andrea Ungar, Daniela Balzi, Salvatore Gangemi, Antonio Faraone, Aldo Lo Forte, Ilaria Del Lungo, Primo Buscemi, Chiara Lorini, and Giacomo Fortini
Subjects: COVID-19, Hospital-at-home, Integrated medicine, Intermediate care, Mortality, Nursing home, Aging, medicine.medical_specialty, Coronavirus disease 2019 (COVID-19), Intervention (counseling), Health care, Pandemic, medicine, Infection transmission, Humans, Aged, Hospitalization, Hospitals, Nursing Homes, SARS-CoV-2, business.industry, Emergency medicine, Diagnostic assessment, Original Article, Geriatrics and Gerontology, Nursing homes, business
Abstract: Background Nursing home (NH) residents have been dramatically affected by COVID-19, with extremely high rates of hospitalization and mortality. Aims To describe the features and impact of an assistance model involving an intermediate care mobile medical specialist team (GIROT, Gruppo Intervento Rapido Ospedale Territorio) aimed at delivering “hospital-at-nursing home” care to NH residents with COVID-19 in Florence, Italy. Methods The GIROT activity was set-up during the first wave of the pandemic (W1, March–April 2020) and became a structured healthcare model during the second (W2, October 2020–January 2021). The activity involved (1) infection transmission control among NHs residents and staff, (2) comprehensive geriatric assessment including prognostication and geriatric syndromes management, (3) on-site diagnostic assessment and protocol-based treatment of COVID-19, (4) supply of nursing personnel to understaffed NHs. To estimate the impact of the GIROT intervention, we reported hospitalization and infection lethality rates recorded in SARS-CoV-2-positive NH residents during W1 and W2. Results The GIROT activity involved 21 NHs (1159 residents) and 43 NHs (2448 residents) during W1 and W2, respectively. The percentage of infected residents was higher in W2 than in W1 (64.5% vs. 38.8%), while both hospitalization and lethality rates significantly decreased in W2 compared to W1 (10.1% vs 58.2% and 23.4% vs 31.1%, respectively). Discussion Potentiating on-site care in the NHs paralleled a decrease of hospital admissions with no increase of lethality. Conclusions An innovative “hospital-at-nursing home” patient-centred care model based on comprehensive geriatric assessment may provide a valuable contribution in fighting COVID-19 in NH residents.
Published: 2021

3. Test–retest reliability and measurement error of the modified gait efficacy scale in individuals with stroke

Author: Kênia Kp Menezes, Patrick Roberto Avelino, Iza Faria Fortini, Maria Tereza Mota Alvarenga, Lucas R. Nascimento, and Luci Fuscaldi Teixeira-Salmela
Subjects: Male, medicine.medical_specialty, Observational error, Scale (ratio), business.industry, Reproducibility of Results, Physical Therapy, Sports Therapy and Rehabilitation, Walking, Middle Aged, Outcome assessment, medicine.disease, Test (assessment), Stroke, Gait (human), Physical medicine and rehabilitation, Humans, Medicine, business, Gait, Brazil, Reliability (statistics), Aged
Abstract: To investigate the test-retest reliability and measurement error of the Brazilian version of the modified Gait Efficacy scale (mGES-Brazil) in individuals who have had stroke.The mGES-Brazil was applied on two occasions, five to seven days apart, in a research laboratory setting. Test-retest reliability and measurement error, which included the standard error of measurement (SEM), smallest detectable change (SDC), and analysis of the limits of agreement by the Bland-Altman plots, were examined.Fifty individuals who have had stroke (18 men), with a mean age of 64 ± 11 years, were evaluated. All individual items showed good reliability (Intra-class Correlation Coefficient - ICCThe mGES-Brazil demonstrated to be reliable to be applied within clinical and research contexts for the assessment of changes in walking confidence of individuals who have had stroke. Changes in mGES scores ≥8 points reflect real changes.
Published: 2021
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4. Admission Braden Scale Score as an Early Independent Predictor of In‐Hospital Mortality Among Inpatients With COVID‐19: A Retrospective Cohort Study

Author: Antonio Faraone, Elena Lovicu, and Alberto Fortini
Subjects: Male, medicine.medical_specialty, Nursing assessment, outcomes, Logistic regression, Cohort Studies, Patient Admission, COVID‐19, Predictive Value of Tests, Barthel scale, Internal medicine, Humans, Medicine, Hospital Mortality, Pandemics, General Nursing, Aged, Retrospective Studies, Aged, 80 and over, Frailty, SARS-CoV-2, business.industry, Medical record, COVID-19, Retrospective cohort study, Original Articles, Braden Scale, General Medicine, Middle Aged, medicine.disease, Italy, Cohort, Original Article, Female, business, Kidney disease, Cohort study
Abstract: Background The COVID‐19 pandemic has put a strain on health systems. Predictors of adverse outcomes need to be investigated to properly manage COVID‐19 patients. The Braden Scale (BS), commonly used for the assessment of pressure ulcer risk, has recently been proposed to identify frailty. Objective To investigate the predictive utility of the BS for prediction of in‐hospital mortality in a cohort of COVID‐19 patients admitted to non‐ICU wards. Methods We conducted a retrospective single‐center cohort study evaluating all patients with SARS‐CoV‐2 infection consecutively admitted over a 2‐month period (from March 6 to May 7, 2020) to the COVID‐19 general wards of our institution. Demographic, clinical, and nursing assessment data, including admission BS, were extracted from electronic medical records. Univariable and multivariable logistic regression models were used to explore the association between the BS score and in‐hospital death. Results Braden Scale was assessed in 146 patients (mean age 74.7 years; 52% males). On admission, 46 had a BS ≤ 15, and 100 patients had a BS > 15. Mortality among patients with BS ≤ 15 was significantly higher than in patients with BS > 15 (45.7% vs. 16%; p
Published: 2021
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5. Functional mobility in Parkinson’s disease: associations with motor and non-motor symptoms

Author: Lílian Viana Dos Santos Azevedo, Paula Luciana Scalzo, Iza Faria-Fortini, Jéssica Ramos Pereira, and Ana Carolina de Souza Cruz
Subjects: Gynecology, medicine.medical_specialty, business.industry, medicine, Non motor, General Medicine, business
Abstract: Functional mobility (FM) is the ability of people to move in different environments, including at home, at work, and in the community, in order to perform functional activities or tasks, independently and safely. Objective: The aim of the present study was to investigate which motor and/or non-motor symptoms (severity of the motor symptoms, depressive symptoms, and fatigue) have the greatest impact on FM assessed by Modified Parkinson Activity Scale (mPAS) in individuals with Parkinson’s disease (PD). Method: The outcome of interest was FM assessed by mPAS, which includes 14 activities covering three domains (chair transfers, gait akinesia, and bed mobility). Unified Parkinson’s Disease Rating Scale (UPDRS) Part III, Beck Depression Inventory (BDI), and Parkinson’s Disease Fatigue Scale-16 (PFS-16) were used. Results: Forty-four individuals (age: 65±11 years) with PD (PD duration: 7±4 years) were eligible to take part in this cross-sectional, exploratory study. The motor symptoms alone explained 36% (F= 17.85, p
Published: 2021
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6. Impact of the preparation method of red cell concentrates on transfusion indices in thalassemia patients: A randomized crossover clinical trial

Author: Roberto Reverberi, Elena Borotti, Maria Vittoria Riontino, Roberta Chicchi, M. R. Gamberini, Ruggero Buonocore, Daniela Lasagni, Giuseppina Angela Portararo, Monica Fortini, Eleonora Calori, Donatella Venturelli, Francesco Fagnoni, Maurizio Govoni, Alice Stievano, G. Ceccherelli, and Rino Biguzzi
Subjects: Adult, Male, medicine.medical_specialty, Erythrocytes, Thalassemia, Immunology, Buffy coat, 030204 cardiovascular system & hematology, urologic and male genital diseases, Gastroenterology, Hemoglobins, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, Humans, Immunology and Allergy, Medicine, Prospective Studies, Whole blood, Cross-Over Studies, Red Cell, Transfusion Medicine, business.industry, Transfusion Reaction, Plasmapheresis, Hematology, Middle Aged, medicine.disease, female genital diseases and pregnancy complications, Clinical trial, Treatment Outcome, Leukoreduction, Quartile, Female, Hemoglobin, Leukocyte Reduction Procedures, Erythrocyte Transfusion, business, RBC transfusion, 030215 immunology
Abstract: Background The average hemoglobin content of red cell concentrates (RCC) varies depending on the method of preparation. Surprisingly less data are available concerning the clinical impact of those differences. Study Design and Methods The effects of two types of RCC (RCC‐A, RCC‐B) on transfusion regime were compared in a non‐blinded, prospective, randomized, two‐period, and crossover clinical trial. RCC‐A was obtained by whole blood leukoreduction and subsequent plasma removal, RCC‐B removing plasma and buffy coat first, followed by leukoreduction. Eligible patients were adult, with transfusion‐dependent thalassemia (TDT). Results RCC‐A contained 63.9 (60.3–67.8) grams of hemoglobin per unit (median with 1st and 3rd quartile), RCC‐B 54.5 (51.0–58.2) g/unit. Fifty‐one patients completed the study. With RCC‐B, the average pre‐transfusion hemoglobin concentration was 9.3 ± 0.5 g/dl (mean ± SD), the average transfusion interval 14.2 (13.7–16.3) days, the number of RCC units transfused per year 39.3 (35.4–47.3), and the transfusion power index (a composite index) 258 ± 49. With RCC‐A, the average pre‐transfusion hemoglobin concentration was 9.6 ± 0.5 g/dl (+2.7%, effect size 0.792), the average transfusion interval 14.8 (14.0–18.5) days (+4.1%, effect size 0.800), the number of RCC units transfused per year 34.8 (32.1–42.5) (−11.4%, effect size −1.609), and the transfusion power index 272 ± 61 (+14.1%, effect size 0.997). All differences were statistically highly significant (p
Published: 2021
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7. Fall Efficacy Scale–International cut-off score discriminates fallers and non-fallers individuals who have had stroke

Author: Luci Fuscaldi Teixeira-Salmela, Christina Danielli Coelho de Morais Faria, Lucas R. Nascimento, Janaine Cunha Polese, Iza Faria-Fortini, and Aline Alvim Scianni
Subjects: Male, Complementary and Manual Therapy, medicine.medical_specialty, medicine.medical_treatment, Physical Therapy, Sports Therapy and Rehabilitation, Timed Up and Go test, 03 medical and health sciences, 0302 clinical medicine, Physical medicine and rehabilitation, Humans, Medicine, Postural Balance, Stroke, 030222 orthopedics, Rehabilitation, Receiver operating characteristic, business.industry, 030229 sport sciences, medicine.disease, Gait, Preferred walking speed, Cross-Sectional Studies, Complementary and alternative medicine, Time and Motion Studies, Scale (social sciences), Accidental Falls, business, Cadence
Abstract: Background Falls, which are common events after stroke, may lead to activity limitations and increased dependence. It is important to identify which commonly employed clinical measures could differentiate individuals, who are fallers from the non-fallers. Aim To investigate specific cut-off values of clinical measures that could discriminate fallers and non-fallers individuals with chronic stroke. Method This cross-sectional study involved 105 community-dwelling individuals with stroke. The primary outcome was report of falls over the last six months. The clinical predictors included measures of mobility (walking speed, stair ascent/descent cadences, time to perform the Timed Up and Go test, and ABILOCO) and the Fall Efficacy Scale - International (FES-I) scores. To identify which measures were able to detect between-group differences, independent Student's t-tests were employed. For measures which were able to discriminate fallers from the non-fallers, the Receiver Operating Characteristics (ROC) and the Area Under the ROC Curve (AUC) were calculated. Results Out of the 105 participants (61 men), 41% reported falls over the previous 6 months. Stair ascent cadence, ABILOCO, and FES-I scores significantly differentiated the groups, but only the FES-I demonstrated acceptable discriminatory ability (AUC = 0.71). The optimal FES-I cut-off score was 28 points (sensitivity = 0.71; specificity = 0.57; positive predictive value = 51%; and negative predictive value = 74%). Conclusions The FES-I demonstrated good discriminatory ability to classify individuals with chronic stroke, who were fallers from the non-fallers. The use of the established cut-off value of 28 points is recommended and may help clinical reasoning and decision-making in stroke rehabilitation.
Published: 2021
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8. Italian Vascular Flora: New Findings, Updates and Exploration of Floristic Similarities between Regions

Author: Paola Fortini, Carmelo Maria Musarella, Adriano Stinca, Simonetta Fascetti, Valentina Laface, Claudia Angiolini, Wolfgang Licht, Robert P. Wagensommer, Gianluca Nicolella, Giacomo Mei, Assunta Esposito, Giuseppina Chianese, Giovanni Salerno, Romeo Di Pietro, Tiberio Fiaschi, Giampiero Ciaschetti, Leopoldo De Simone, Leonardo Rosati, Gabriele Galasso, Emanuele Fanfarillo, Enrico V. Perrino, Stinca, A., Musarella, C. M., Rosati, L., Laface, V. L. A., Licht, W., Fanfarillo, E., Wagensommer, R. P., Galasso, G., Fascetti, S., Esposito, A., Fiaschi, T., Nicolella, G., Chianese, G., Ciaschetti, G., Salerno, G., Fortini, P., Di Pietro, R., Perrino, E. V., Angiolini, C., De Simone, L., and Mei, G.
Subjects: Systematics, Flora, QH301-705.5, Biological recording, Invasive plant, Distribution (economics), Introduced species, Herborization, floristic studies, Native specie, Floristics, floristic inventories, invasive plants, Biology (General), Endemism, Nature and Landscape Conservation, new floristic records, Ecology, business.industry, native species, Ecological Modeling, Floristic inventorie, Herbaria, New floristic record, Apennine peninsula, biological recording, exotic species, herbaria, herborization, Italy, plant diversity, regional flora, Floristic studie, Agricultural and Biological Sciences (miscellaneous), Geography, Herbarium, Taxon, Plant diversity, Regional flora, Exotic specie, business
Abstract: The tradition of floristic studies in Italy has made it possible to obtain a good knowledge of plant diversity both on a national and regional scale. However, the lack of knowledge for some areas, advances in plant systematics and human activities related to globalization, highlight the need for further studies aimed at improving floristic knowledge. In this paper, based on fieldwork and herbaria and literature surveys, we update the knowledge on the Italian vascular flora and analyze the floristic similarities between the administrative regions. Four taxa, all exotic, were recorded for the first time in Italy and Europe. In detail, Elaeodendron croceum, Kalanchoë blossfeldiana, and Sedum spathulifolium var. spathulifolium were found as casual aliens, while Oxalis brasiliensis was reported as historical record based on some herbarium specimens. Furthermore, Kalanchoë laxiflora was confirmed as a casual alien species for Italy and Europe. Status changes for some taxa were proposed at both national and regional levels, as well as many taxa were reported as new or confirmed at the regional level. Currently the Italian vascular flora comprises 9150 taxa of which 7547 are native (of which 1598 are Italian endemics) and 1603 are exotic at the national level. The multivariate analysis of updated floristic data on a regional scale showed a clear distribution along the latitudinal gradient, in accordance with the natural geographical location of the regions in Italy. This pattern of plants distribution was not affected by the introduction of alien species. Despite some taxonomic and methodological issues which are still open, the data obtained confirm the important role of floristic investigations in the field and in herbaria, as well as the collaborative approach among botanists, in order to improve the knowledge of the Italian and European vascular flora.
Published: 2021
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9. Aerobic exercise, but not isometric handgrip exercise, improves endothelial function and arterial stiffness in patients with myocardial infarction undergoing coronary intervention: a randomized pilot study

Author: Ana Marenco, Alexandre Machado Lehnen, Bruna Eibel, Nathan L. Bellé, Eduardo Barbosa, Daniel P. Kollet, Gustavo Waclawovsky, and Liliana Fortini Cavalheiro Boll
Subjects: Male, lcsh:Diseases of the circulatory (Cardiovascular) system, Time Factors, Brachial Artery, medicine.medical_treatment, Pilot Projects, Isometric exercise, 030204 cardiovascular system & hematology, 0302 clinical medicine, Myocardial infarction, Brachial artery, Pulse wave velocity, Hand Strength, Middle Aged, Arterial stiffness, Exercise Therapy, Vasodilation, medicine.anatomical_structure, Treatment Outcome, Cardiology, cardiovascular system, Female, Cardiology and Cardiovascular Medicine, Brazil, Research Article, medicine.medical_specialty, 03 medical and health sciences, Percutaneous Coronary Intervention, Vascular Stiffness, Internal medicine, medicine.artery, Isometric Contraction, medicine, Aerobic exercise, Humans, Arterial Pressure, cardiovascular diseases, Aged, business.industry, Percutaneous coronary intervention, Endothelial function, 030229 sport sciences, medicine.disease, lcsh:RC666-701, Vascular resistance, Isometric handgrip exercise, ST Elevation Myocardial Infarction, Vascular Resistance, Endothelium, Vascular, business
Abstract: Background Aerobic exercise improves endothelial function and arterial stiffness after myocardial infarction (MI), but the effects of isometric exercise on cardiovascular parameters are still uncertain. We aimed to assess the effects of one session of aerobic or isometric exercise on flow-mediated dilation (FMD) and pulse wave velocity (PWV) in post-MI volunteers undergoing percutaneous coronary intervention (PCI). Methods Twenty post-MI patients undergoing PCI were randomized to aerobic (AE, n = 10) or isometric (IE, n = 10) exercise groups. We evaluated cardiac structure and function (echocardiographic); carotid plaque presence (ultrasound). FMD and PWV were measured 10 min before and 10 min after the intervention: a single session of moderate-intensity AE (30 min; ratings 12–14 on Borg’s scale or 50–60% HRreserve) or handgrip IE (four two-minute bilateral contractions; 30% maximal voluntary contraction; 1-min rest). Generalized estimating equations (Bonferroni post-hoc) was used to assess differences (p ≤ 0.050). Results FMD improved only in the AE group (Δ = 4.9%; p = 0.034), with no difference between groups after exercise. Even after adjustment (for baseline brachial artery diameter) the effectiveness of AE remained (p = 0.025) with no change in the IE group. PWV was slightly reduced from baseline in the AE group (Δ = 0.61 m/s; p = 0.044), and no difference when compared to the IE group. Peripheral vascular resistance decreased in AE versus IE (p = 0.050) and from baseline (p = 0.014). Conclusions Vascular measurements (FMD and PWV) improved after a single session of AE. There are apparently no benefits following a session of IE. Trial registration http://www.clinicaltrials.gov and ID number NCT04000893.
Published: 2021

10. Introduction to the Italian translation of Fredric Jameson’s Marxism and Form

Author: Franco Fortini and Toscano Alberto
Subjects: Literature, History, Sociology and Political Science, business.industry, Philosophy, Political Science and International Relations, business, Translation (geometry), General Economics, Econometrics and Finance, Social Sciences (miscellaneous)
Abstract: This text is essayist, critic and poet Franco Fortini’s introduction to the Italian translation of Fredric Jameson’s Marxism and Form. Fortini frames his assessment of Jameson in terms of a contrast with the Italian reception of the dialectical criticism assayed in Marxism and Form.
Published: 2021
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11. Estrategias para disminuir infecciones en terapia intensiva pediátrica polivalente

Author: Yanina Vanesa Fortini
Subjects: business.industry, General Engineering, General Earth and Planetary Sciences, Medicine, business, General Environmental Science
Published: 2021
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12. Over time relationship between platelet reactivity, myocardial injury and mortality in patients with SARS-CoV-2-associated respiratory failure

Author: Roberto Ferrari, Paola Rizzo, Marco Verri, Carlo Alberto Volta, Rita Pavasini, Simone Biscaglia, Alberto Papi, Roberto Zoppellari, Marco Contoli, Luca Ronzoni, Ottavio Zucchetti, Gianluca Campo, Savino Spadaro, Francesco Vieceli Dalla Sega, Alberto Fogagnolo, Luca Di Ienno, Francesca Fortini, Marco Manfrini, Emanuele D'Aniello, and Luca Morandi
Subjects: Blood Platelets, Male, 0301 basic medicine, medicine.medical_specialty, Heart Injury, P-selectin, Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), CD40 Ligand, soluble CD40 ligand, 030204 cardiovascular system & hematology, NO, COVID-19, myocardial injury, platelet aggregation, P-selectin, soluble CD40 ligand, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, Humans, Medicine, myocardial injury, In patient, Platelet, Platelet activation, Aged, Aged, 80 and over, CD40, biology, SARS-CoV-2, business.industry, Myocardium, COVID-19, Hematology, General Medicine, Middle Aged, 030104 developmental biology, Heart Injuries, Respiratory failure, platelet aggregation, biology.protein, Cardiology, Female, Respiratory Insufficiency, business, Biomarkers, Research Article
Abstract: The aim of this study (NCT04343053) is to investigate the relationship between platelet activation, myocardial injury, and mortality in patients affected by Coronavirus disease 2019 (COVID-19). Fifty-four patients with respiratory failure due to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection were enrolled as cases. Eleven patients with the same clinical presentation, but negative for SARS-CoV-2 infection, were included as controls. Blood samples were collected at three different time points (inclusion [T1], after 7 ± 2 days [T2] and 14 ± 2 days [T3]). Platelet aggregation by light transmittance aggregometry and the circulating levels of soluble CD40 ligand (sCD40L) and P-selectin were measured. Platelet biomarkers did not differ between cases and controls, except for sCD40L which was higher in COVID-19 patients (p = .003). In COVID-19 patients, P-selectin and sCD40L levels decreased from T1 to T3 and were higher in cases requiring admission to intensive care unit (p = .004 and p = .008, respectively). Patients with myocardial injury (37%), as well as those who died (30%), had higher values of all biomarkers of platelet activation (p
Published: 2020
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13. Six-month prognostic impact of hemodynamic profiling by short minimally invasive monitoring after cardiac surgery

Author: Marco Chiostri, Valentina Spini, Niccolò Marchionni, Cristina Giglioli, Salvatore Mario Romano, Giacomo Fortini, Emanuele Cecchi, and Pierluigi Stefàno
Subjects: medicine.medical_specialty, Framingham Risk Score, Cardiac cycle, business.industry, Hemodynamics, 030208 emergency & critical care medicine, hemodynamic profile, 030204 cardiovascular system & hematology, Logistic regression, Cardiac surgery, 03 medical and health sciences, 0302 clinical medicine, cardiac-surgery, Internal medicine, RC666-701, Cardiology, Medicine, Arterial pH, Diseases of the circulatory (Cardiovascular) system, Original Article, Observational study, Cardiology and Cardiovascular Medicine, Adverse effect, business, clinical six months follow-up
Abstract: Introduction: Studies have shown that a hemodynamic-guided therapy improves the post operative outcomes of high-risk patients.This study, evaluated if a short period through minimally invasive hemodynamic monitoring, pressure recording analytical method (PRAM), on admission to a post-cardiac surgery step-down unit (SDU), may identify patients at higher risk of 6-month adverse events after cardiac surgery. Methods: From December 2016-May 2017,173 patients were admitted in SDU within 24-48 hours of major cardiac surgery procedure, and submitted to clinical, laboratoristic and echocardiographic evaluation and a 1-hour PRAM recording to obtain a "biohumoral snapshot" of individual patient’s.156 173 patients (17 patients were lost at follow-up) were phone interviewed six months after surgery,to evaluate, as a composite end-point, the adverse events during follow-up. A multivariable logistic regression analysis was used to identify a model clinical-biohumoral (CBM) and clinical-biohumoral hemodynamics (CBHM). Results: No data from past clinical history and no conventional risk score (EuroScore II, STS score)independently predicted the risk of 6-month major events in our study. The risk of adverse events at six-month follow-up was directly related, in the CBM, to sustained post-operative cardiac arrhythmias, higher values of NT-proBNP and of arterial pH; inversely related to values of hs-C-reactive protein (hs-CRP) and, in the CBHM, to low values of cardiac cycle efficiency (CCE) and dP/dtmax. Conclusion: Our study although limited by its observational nature and by the limited number of patients enrolled, showed that a short period of minimally invasive hemodynamic monitoring increased the accuracy to identify patients at major risk of mid-term events after cardiac surgery.
Published: 2020

14. The Paradox of the Low Prevalence of Current Smokers Among COVID-19 Patients Hospitalized in Nonintensive Care Wards: Results From an Italian Multicenter Case–Control Study

Author: Alberto Fortini, Carlo Tascini, Leonardo Alberto Sechi, Roberto Andreini, and Simone Meini
Subjects: Male, medicine.medical_specialty, Prevalence, 030204 cardiovascular system & hematology, Logistic regression, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, AcademicSubjects/SOC02541, Humans, Medicine, 030212 general & internal medicine, Aged, Smokers, SARS-CoV-2, business.industry, Brief Report, Risk of infection, Public health, Public Health, Environmental and Occupational Health, Case-control study, COVID-19, Odds ratio, Confidence interval, Hospitalization, Italy, Case-Control Studies, Female, Observational study, AcademicSubjects/MED00010, business
Abstract: Introduction COVID-19, a respiratory illness due to SARS-CoV-2 coronavirus, was first described in December 2019 in Wuhan, rapidly evolving into a pandemic. Smoking increases the risk of respiratory infections; thus, cessation represents a huge opportunity for public health. However, there is scarce evidence about if and how smoking affects the risk of SARS-CoV-2 infection. Methods We performed an observational case–control study, assessing the single-day point prevalence of smoking among 218 COVID-19 adult patients hospitalized in seven Italian nonintensive care wards and in a control group of 243 patients admitted for other conditions to seven COVID-19-free general wards. We compared proportions for categorical variables by using the χ 2 test and performed univariate and multivariate logistic regression analyses to identify the variables associated with the risk of hospitalization for COVID-19. Results The percentages of current smokers (4.1% vs 16%, p = .00003) and never smokers (71.6% vs 56.8%, p = .0014) were significantly different between COVID-19 and non-COVID 19 patients. COVID-19 patients had lower mean age (69.5 vs 74.2 years, p = .00085) and were more frequently males (59.2% vs 44%, p = .0011). In the logistic regression analysis, current smokers were significantly less likely to be hospitalized for COVID-19 compared with nonsmokers (odds ratio = 0.23; 95% confidence interval, 0.11–0.48, p < .001), even after adjusting for age and gender (odds ratio = 0.14; 95% confidence interval, 0.06–0.31, p < .001). Conclusions We reported an unexpectedly low prevalence of current smokers among COVID-19 patients hospitalized in nonintensive care wards. The meaning of these preliminary findings, which are in line with those currently emerging in literature, is unclear; they need to be confirmed by larger studies. Implications An unexpectedly low prevalence of current smokers among patients hospitalized for COVID-19 in some Italian nonintensive care wards is reported. This finding could be a stimulus for the generation of novel hypotheses on individual predisposition and possible strategies for reducing the risk of infection from SARS-CoV-2 and needs to be confirmed by further larger studies designed with adequate methodology.
Published: 2020
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15. Inappropriate use of carbapenems in an internal medicine ward: Impact of a carbapenem-focused antimicrobial stewardship program

Author: Chiara Cappugi, Antonio Faraone, Tommaso Giani, Eleonora Riccobono, Alice Poggi, Alberto Fortini, and Lorenzo Tofani
Subjects: medicine.medical_specialty, Carbapenem, Klebsiella pneumoniae, 030204 cardiovascular system & hematology, Interrupted Time Series Analysis, Antimicrobial Stewardship, 03 medical and health sciences, 0302 clinical medicine, Enterobacterales, Internal medicine, Drug Resistance, Bacterial, polycyclic compounds, Internal Medicine, medicine, Humans, Antimicrobial stewardship, 030212 general & internal medicine, Medical prescription, biology, business.industry, Incidence (epidemiology), Limiting, biochemical phenomena, metabolism, and nutrition, bacterial infections and mycoses, biology.organism_classification, Hospitals, Anti-Bacterial Agents, Klebsiella Infections, Carbapenems, bacteria, business, medicine.drug
Abstract: Carbapenem consumption is a major driver for selection and spread of carbapenem-resistant Enterobacterales (CRE). We assessed the impact of a carbapenem-focused multimodal antimicrobial stewardship program (ASP) in the internal medicine unit of a medium-size acute-care hospital.We compared the percentage of inappropriate carbapenem prescriptions and the proportion of carbapenem treated patients registered in a 12-month pre-intervention and in a 24-month post-intervention period by using an interrupted time series analysis. The consumption of carbapenems, expressed in defined daily doses (DDD), was also assessed. As a secondary objective, the incidence of infections by carbapenem-resistant Klebsiella pneumoniae (CRKP) and the percentage of CRKP invasive isolates in the same time periods were compared.After the ASP intervention, the mean monthly percentage of inappropriate carbapenem prescriptions dropped from 59% to 25%, and the mean monthly proportion of carbapenem treated patients decreased from 3% to 1%. The interrupted time series analysis confirmed a significant decrease in the percentage of inappropriate carbapenem prescriptions (-41.6%, p = 0.0262) and in the proportion of carbapenem treated patients (-2.1%, p 0.0001). Carbapenem consumption decreased from 5.2 to 1.6 DDD x 100 patient-days. The incidence of CRKP infections remained unchanged (29.1 × 100,000 patient-days vs 28.9 × 100,000 patient-days, p = 0.9864) and the percentage of CRKP invasive isolates decreased, though not significantly, from 36.4% to 13.3% (p = 0.3478).The implementation of a carbapenem-focused ASP was effective at limiting the inappropriate use of carbapenems and was associated with a significant decrease in carbapenem consumption. Such effects were sustained during a 24-month post-intervention period.
Published: 2020
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16. Neurological consultations and diagnoses in a large, dedicated COVID-19 university hospital

Author: Ricardo Nitrini, Jerusa Smid, Matheus Dalben Fiorentino, Maíra Medeiros Honorato Ferrari, Tarso Adoni, Mariana Hiromi Manoel Oku, Luiz Henrique Martins Castro, Carlos Otto Heise, Gabriela Pantaleão Moreira, Sonia Maria Dozzi Brucki, Márcia Rúbia Rodrigues Gonçalves, Raphael Ribeiro Spera, Rodrigo de Holanda Mendonça, Adalberto Studart-Neto, Júlia Chartouni Rodrigues, Rafael Bernhart Carra, André Macedo Serafim da Silva, Tomás Fraga Ferreira Da Silva, Cesar Castello Branco Lopes, Raphael de Luca e Tuma, Bruno Diógenes Iepsen, Edmar Zanoteli, Antonio Edvan Camelo Filho, Cristiane de Araújo Martins Moreno, Sara Terrim, Carlos Eduardo Borges Passos Neto, Julia Carvalhinho Carlos De Souza, Bruno Fukelmann Guedes, Lécio Figueira Pinto, José Pedro Soares Baima, Ida Fortini, Samira Luisa dos Apostolos Pereira, Gabriel Taricani Kubota, Adriana Bastos Conforto, and Hélio Rodrigues Gomes
Subjects: medicine.medical_specialty, Neurology, Encephalopathy, Pneumonia, Viral, MEDLINE, Anosmia, Neurosciences. Biological psychiatry. Neuropsychiatry, law.invention, Hospitals, University, Betacoronavirus, law, Seizures, medicine, Humans, Medical diagnosis, Stroke, Pandemics, Referral and Consultation, Retrospective Studies, business.industry, SARS-CoV-2, COVID-19, Retrospective cohort study, Metabolic Encephalopathy, Neuromuscular Diseases, medicine.disease, Intensive care unit, Hospital Bed Capacity, Emergency medicine, Neurology (clinical), medicine.symptom, Nervous System Diseases, business, Coronavirus Infections, Brazil, RC321-571
Abstract: Background: More than one-third of COVID-19 patients present neurological symptoms ranging from anosmia to stroke and encephalopathy. Furthermore, pre-existing neurological conditions may require special treatment and may be associated with worse outcomes. Notwithstanding, the role of neurologists in COVID-19 is probably underrecognized. Objective: The aim of this study was to report the reasons for requesting neurological consultations by internists and intensivists in a COVID-19-dedicated hospital. Methods: This retrospective study was carried out at Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, Brazil, a 900-bed COVID-19 dedicated center (including 300 intensive care unit beds). COVID-19 diagnosis was confirmed by SARS-CoV-2-RT-PCR in nasal swabs. All inpatient neurology consultations between March 23rd and May 23rd, 2020 were analyzed. Neurologists performed the neurological exam, assessed all available data to diagnose the neurological condition, and requested additional tests deemed necessary. Difficult diagnoses were established in consensus meetings. After diagnosis, neurologists were involved in the treatment. Results: Neurological consultations were requested for 89 out of 1,208 (7.4%) inpatient COVID admissions during that period. Main neurological diagnoses included: encephalopathy (44.4%), stroke (16.7%), previous neurological diseases (9.0%), seizures (9.0%), neuromuscular disorders (5.6%), other acute brain lesions (3.4%), and other mild nonspecific symptoms (11.2%). Conclusions: Most neurological consultations in a COVID-19-dedicated hospital were requested for severe conditions that could have an impact on the outcome. First-line doctors should be able to recognize neurological symptoms; neurologists are important members of the medical team in COVID-19 hospital care.
Published: 2020

17. Association between walking and strength of lower limbs after chronic stroke

Author: Pollyana Helena Vieira Costa, Camila Torriani-Pasin, Brenno Belchior Cordeiro Silva, Iza Faria-Fortini, and Janaine Cunha Polese
Subjects: medicine.medical_specialty, business.industry, Muscle weakness, General Medicine, Isometric exercise, medicine.disease, Preferred walking speed, Physical medicine and rehabilitation, medicine.anatomical_structure, Walk test, medicine, medicine.symptom, Ankle, Muscle group, business, human activities, Stroke, Chronic stroke
Abstract: Certain muscle groups strength directly influence walking speed (WS), and the lower strength of the paretic side is significantly associated with lower WS of individuals after stroke. Studies that have investigated the association between the average of lower limb strength and the WS in individuals are scarce. Therefore, it is important to determine whether the strength could explain walking performance due to some muscle weakness could be compensated by the strength of others, mainly because all muscles act in group, not isolated. Objective: To investigate the association between WS and lower limbs muscle strength, and to identify whether an individual muscle group or the average strength of lower limb would best predict WS and walking speed reserve (WSR) in individuals with stroke. Methods: Sixty-four community-dwelling individuals with chronic stroke have their maximum isometric strength (hip flexors/extensors/abductors, knee flexors/extensors, and ankle dorsiflexors/plantarflexors) and self-selected and fast WS (10m walk test) measured. WSR was considered as the difference between the fast and self-selected speed. Results: Average strength of the paretic limb accounted for 19% and 20% of the variance in self-selected and fast WS, respectively. Plantarflexor strength of the paretic, knee and hip flexors of the non-paretic side explained alone 27% of the WSR scores and plantarflexor strength of the paretic side alone explained 15%.Conclusion: Average muscle strength of the paretic side contributed to self-selected and fast WS. Plantarflexor strength of the paretic side, knee and hip flexors of the non-paretic side contributed with the WSR of chronic stroke individuals.
Published: 2020
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18. Characteristic of chronic plaque psoriasis patients treated with biologics in Italy during the COVID-19 pandemic. risk analysis from the PSO-BIO-COVID observational study

Author: Talamonti, Marina, Galluzzo, Marco, Chiricozzi, Andrea, Quaglino, Pietro, Fabbrocini, Gabriella, Gisondi, Paolo, Marzano, Angelo Valerio, Potenza, Concetta, Conti, Andrea, Parodi, Aurora, Piaserico, Stefano, Bardazzi, Federico, Argenziano, Giuseppe, Rongioletti, Franco, Stingeni, Luca, Micali, Giuseppe, Loconsole, Francesco, Rossi, Maria Teresa, Bongiorno, Maria Rita, Feliciani, Claudio, Rubegni, Pietro, Amerio, Paolo, Fargnoli, Maria Concetta, Pigatto, Paolo, Savoia, Paola, Nisticò, Steven Paul, Giustini, Sandra, Carugno, Andrea, Cannavo', Serafinella Patrizia, Rech, Giulia, Prignano, Francesca, Offidani, Annamaria, Lombardo, Maurizio, Zalaudek, Iris, Bianchi, Luca, Peris, Ketty, PSO-BIO-COVID study group, Balestri R, Bernardini N, Belloni Fortini A, Burlando M, Caldarola G, Campione E, Cattaneo A, Dapavo P, Dastoli S, De Simone C, Di Nuzzo S, Diotallevi F, Fierro MT, Franchi C, Esposito M, Foti C, Gambini DM, Gambardella A, Girolomoni G, Giunta A, Guarneri C, Gualdi G, Hansel K, Megna M, Mugheddu C, Musumeci ML, Patrizi A, Pellacani G, Richetta AG, Rosi E, Sacchelli L, Tiberio R, Tilotta G, Trovato E, Venturini M, Vezzoni R, Talamonti, M., Galluzzo, M., Chiricozzi, A., Quaglino, P., Fabbrocini, G., Gisondi, P., Marzano, A. V., Potenza, C., Conti, A., Parodi, A., Piaserico, S., Bardazzi, F., Argenziano, G., Rongioletti, F., Stingeni, L., Micali, G., Loconsole, F., Rossi, M. T., Bongiorno, M. R., Feliciani, C., Rubegni, P., Amerio, P., Fargnoli, M. C., Pigatto, P., Savoia, P., Nistico, S. P., Giustini, S., Carugno, A., Cannavo', S. P., Rech, G., Prignano, F., Offidani, A., Lombardo, M., Zalaudek, I., Bianchi, L., Peris, K., Talamonti, M, Galluzzo, M, Chiricozzi, A, Quaglino, P, Fabbrocini, G, Gisondi, P, Marzano, A, Potenza, C, Conti, A, Parodi, A, Piaserico, S, Bardazzi, F, Argenziano, G, Rongioletti, F, Stingeni, L, Micali, G, Loconsole, F, Rossi, M, Bongiorno, M, Feliciani, C, Rubegni, P, Amerio, P, Fargnoli, M, Pigatto, P, Savoia, P, Nisticò, S, Giustini, S, Carugno, A, Cannavo’, S, Rech, G, Prignano, F, Offidani, A, Lombardo, M, Zalaudek, I, Bianchi, L, Peris, K, Talamonti, Marina, Galluzzo, Marco, Chiricozzi, Andrea, Quaglino, Pietro, Fabbrocini, Gabriella, Gisondi, Paolo, Marzano, Angelo Valerio, Potenza, Concetta, Conti, Andrea, Parodi, Aurora, Piaserico, Stefano, Bardazzi, Federico, Argenziano, Giuseppe, Rongioletti, Franco, Stingeni, Luca, Micali, Giuseppe, Loconsole, Francesco, Rossi, Maria Teresa, Bongiorno, Maria Rita, Feliciani, Claudio, Rubegni, Pietro, Amerio, Paolo, Fargnoli, Maria Concetta, Pigatto, Paolo, Savoia, Paola, Nisticò, Steven Paul, Giustini, Sandra, Carugno, Andrea, Cannavo', Serafinella Patrizia, Rech, Giulia, Prignano, Francesca, Offidani, Annamaria, Lombardo, Maurizio, Zalaudek, Iri, Bianchi, Luca, Peris, Ketty, PSO-BIO-COVID study, Group, Balestri, R, Bernardini, N, Belloni Fortini, A, Burlando, M, Caldarola, G, Campione, E, Cattaneo, A, Dapavo, P, Dastoli, S, De Simone, C, Di Nuzzo, S, Diotallevi, F, Fierro, Mt, Franchi, C, Esposito, M, Foti, C, Gambini, Dm, Gambardella, A, Girolomoni, G, Giunta, A, Guarneri, C, Gualdi, G, Hansel, K, Megna, M, Mugheddu, C, Musumeci, Ml, Patrizi, A, Pellacani, G, Richetta, Ag, Rosi, E, Sacchelli, L, Tiberio, R, Tilotta, G, Trovato, E, Venturini, M, Vezzoni, R, Talamonti M., Galluzzo M., Chiricozzi A., Quaglino P., Fabbrocini G., Gisondi P., Marzano A.V., Potenza C., Conti A., Parodi A., Piaserico S., Bardazzi F., Argenziano G., Rongioletti F., Stingeni L., Micali G., Loconsole F., Rossi M.T., Bongiorno M.R., Feliciani C., Rubegni P., Amerio P., Fargnoli M.C., Pigatto P., Savoia P., Nistico S.P., Giustini S., Carugno A., Cannavo' S.P., Rech G., Prignano F., Offidani A., Lombardo M., Zalaudek I., Bianchi L., and Peris K.
Subjects: 0301 basic medicine, Male, Clinical Biochemistry, Disease, Cohort Studies, 0302 clinical medicine, Drug Discovery, Receptors, 80 and over, Medicine, Aged, 80 and over, education.field_of_study, Incidence (epidemiology), Incidence, Interleukin-17, psoriasis, Middle Aged, dermatology, sars-CoV-2, Italy, biological therapy, 030220 oncology & carcinogenesis, Cohort, Biological Product, COVID-19, Female, Settore MED/35 - MALATTIE CUTANEE E VENEREE, Adult, Aged, Biological Products, Biological Therapy, Chronic Disease, Humans, Pandemics, Psoriasis, Receptors, Interleukin, Risk Assessment, Tumor Necrosis Factor-alpha, Young Adult, Cohort study, Human, medicine.medical_specialty, Population, 03 medical and health sciences, Settore MED/35, Internal medicine, education, Pharmacology, Psoriasi, Pandemic, business.industry, Biological product, Interleukin, medicine.disease, Clinical trial, 030104 developmental biology, SARS-CoV-2, Cohort Studie, business
Abstract: Background The susceptibility of patients with chronic plaque psoriasis and the risks or benefits related to the use of biological therapies for COVID-19 are unknown. Few data about prevalence, clinical course and outcomes of COVID-19 among psoriatic patients were reported. The aims of this study were 1) to assess the prevalence and severity of COVID-19 in psoriatic patients treated with biologic agents during the first phase of the emergency (22 February to 22 April 2020) in Italy, and 2) to report the clinical outcomes of patients who have been exposed to individuals with confirmed SARS-CoV-2 infection. Methods Patients with moderate-to-severe chronic plaque psoriasis, aged ≥18 years and undergoing treatment with biologic agents as of 22 February 2020, were eligible to be included in PSO-BIO-COVID study. Demographic and clinical characteristics of patients using any biologic for psoriasis treatment between 22 February and 22 April 2020 were registered. For all confirmed or suspected cases of COVID-19, data about concomitant disease, ongoing therapies, and comorbidities were also reported. Results A total of 12,807 psoriatic patients were included in the PSO-BIO-COVID study. In this cohort twenty-six patients (0.2%) had a swab confirmation of SARS-CoV-2 infection. Eleven patients required hospitalization and two died. 125 of 12807 patients (1.0%) with exposure to a patient with COVID-19 under quarantine or active health surveillance, were reported. Conclusion The incidence of COVID-19 observed in our cohort of psoriatic patients (0.2%) is similar to that seen in the general population (0.31%) in Italy. However, the course of the disease was mild in most patients. Biological therapies may likely lessen "cytokine storm" of COVID-19, which sometimes lead to multiple organ failure, ARDS, and death.
Published: 2021

19. Synthetic seismic data generation with deep learning

Author: Giacomo Roncoroni, Luca Bortolussi, N. Bienati, C. Fortini, Michele Pipan, Roncoroni, G., Fortini, C., Bortolussi, L., Bienati, N., and Pipan, M.
Subjects: 010504 meteorology & atmospheric sciences, Computational complexity theory, Artificial neural network, Synthetic seismogram, Test data generation, business.industry, Computer science, Deep learning, Seismic modelling, Inverse problem, 010502 geochemistry & geophysics, 01 natural sciences, Synthetic data, Geophysics, Recurrent neural network, Reflection seismic, Machine learning, Artificial intelligence, business, Algorithm, 0105 earth and related environmental sciences
Abstract: We study the applicability of deep learning (DL) methods to generate acoustic synthetic data from 1D models of the subsurface. We designed and implemented a Neural Network (NN) and we trained it to generate synthetic seismograms (common shot gathers) from 1-D velocity models on two different datasets: one obtained from published results and the other generated by Finite Differences (FD) numerical simulation. We furthermore compared the results from the proposed model with the published one. Moreover, we tried to to add more flexibility to this methodology by allowing change of wavelet and the acquisition geometry. We obtained good results in terms of both computation efficiency and quality of prediction. The main potentialities of the work are the low computational cost, a high prediction speed and the possibility to solve complex non-linear problems without knowing the physical law behind the phenomenon, which could led great advantages in the solution also of the inverse problem . DL to generate 1-D acoustic synthetic seismograms without solving wave equation Solution to the 1-D problem through custom Recurrent Neural Network Retraining strategy to improve flexibility and applicability Computational complexity analysis.
Published: 2021

20. Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition) 1

Author: Klionsky, Daniel, Abdel-Aziz, Amal Kamal, Abdelfatah, Sara, Abdellatif, Mahmoud, Abdoli, Asghar, Abel, Steffen, Abeliovich, Hagai, Abildgaard, Marie, Abudu, Yakubu Princely, Acevedo-Arozena, Abraham, Adamopoulos, Iannis, Adeli, Khosrow, Adolph, Timon, Adornetto, Annagrazia, Aflaki, Elma, Agam, Galila, Agarwal, Anupam, Aggarwal, Bharat, Agnello, Maria, Agostinis, Patrizia, Agrewala, Javed, Agrotis, Alexander, Aguilar, Patricia, Ahmad, S Tariq, Ahmed, Zubair, Ahumada-Castro, Ulises, Aits, Sonja, Aizawa, Shu, Akkoc, Yunus, Akoumianaki, Tonia, Akpinar, Hafize Aysin, Al-Abd, Ahmed, Al-Akra, Lina, Al-Gharaibeh, Abeer, Alaoui-Jamali, Moulay, Alberti, Simon, Alcocer-Gómez, Elísabet, Alessandri, Cristiano, Ali, Muhammad, Alim Al-Bari, M Abdul, Aliwaini, Saeb, Alizadeh, Javad, Almacellas, Eugènia, Almasan, Alexandru, Alonso, Alicia, Alonso, Guillermo, Altan-Bonnet, Nihal, Altieri, Dario, Álvarez, Élida, Alves, Sara, Alves Da Costa, Cristine, Alzaharna, Mazen, Amadio, Marialaura, Amantini, Consuelo, Amaral, Cristina, Ambrosio, Susanna, Amer, Amal, Ammanathan, Veena, An, Zhenyi, Andersen, Stig, Andrabi, Shaida, Andrade-Silva, Magaiver, Andres, Allen, Angelini, Sabrina, Ann, David, Anozie, Uche, Ansari, Mohammad, Antas, Pedro, Antebi, Adam, Antón, Zuriñe, Anwar, Tahira, Apetoh, Lionel, Apostolova, Nadezda, Araki, Toshiyuki, Araki, Yasuhiro, Arasaki, Kohei, Araújo, Wagner, Araya, Jun, Arden, Catherine, Arévalo, Maria-Angeles, Arguelles, Sandro, Arias, Esperanza, Arikkath, Jyothi, Arimoto, Hirokazu, Ariosa, Aileen, Armstrong-James, Darius, Arnauné-Pelloquin, Laetitia, Aroca, Angeles, Arroyo, Daniela, Arsov, Ivica, Artero, Rubén, Asaro, Dalia Maria Lucia, Aschner, Michael, Ashrafizadeh, Milad, Ashur-Fabian, Osnat, Atanasov, Atanas, Au, Alicia, Auberger, Patrick, Auner, Holger, Aurelian, Laure, Autelli, Riccardo, Avagliano, Laura, Ávalos, Yenniffer, Aveic, Sanja, Aveleira, Célia Alexandra, Avin-Wittenberg, Tamar, Aydin, Yucel, Ayton, Scott, Ayyadevara, Srinivas, Azzopardi, Maria, Baba, Misuzu, Backer, Jonathan, Backues, Steven, Bae, Dong-Hun, Bae, Ok-Nam, Bae, Soo Han, Baehrecke, Eric, Baek, Ahruem, Baek, Seung-Hoon, Baek, Sung Hee, Bagetta, Giacinto, Bagniewska-Zadworna, Agnieszka, Bai, Hua, Bai, Jie, Bai, Xiyuan, Bai, Yidong, Bairagi, Nandadulal, Baksi, Shounak, Balbi, Teresa, Baldari, Cosima, Balduini, Walter, Ballabio, Andrea, Ballester, Maria, Balazadeh, Salma, Balzan, Rena, Bandopadhyay, Rina, Banerjee, Sreeparna, Banerjee, Sulagna, Bánréti, Ágnes, Bao, Yan, Baptista, Mauricio, Baracca, Alessandra, Barbati, Cristiana, Bargiela, Ariadna, Barilà, Daniela, Barlow, Peter, Barmada, Sami, Barreiro, Esther, Barreto, George, Bartek, Jiri, Bartel, Bonnie, Bartolome, Alberto, Barve, Gaurav, Basagoudanavar, Suresh, Bassham, Diane, Bast, Robert, Basu, Alakananda, Batoko, Henri, Batten, Isabella, Baulieu, Etienne, Baumgarner, Bradley, Bayry, Jagadeesh, Beale, Rupert, Beau, Isabelle, Beaumatin, Florian, Bechara, Luiz, Beck, George, Beers, Michael, Begun, Jakob, Behrends, Christian, Behrens, Georg, Bei, Roberto, Bejarano, Eloy, Bel, Shai, Behl, Christian, Belaid, Amine, Belgareh-Touzé, Naïma, Bellarosa, Cristina, Belleudi, Francesca, Belló Pérez, Melissa, Bello-Morales, Raquel, Beltran, Jackeline Soares de Oliveira, Beltran, Sebastián, Benbrook, Doris Mangiaracina, Bendorius, Mykolas, Benitez, Bruno, Benito-Cuesta, Irene, Bensalem, Julien, Berchtold, Martin, Berezowska, Sabina, Bergamaschi, Daniele, Bergami, Matteo, Bergmann, Andreas, Berliocchi, Laura, Berlioz-Torrent, Clarisse, Bernard, Amélie, Berthoux, Lionel, Besirli, Cagri, Besteiro, Sebastien, Betin, Virginie, Beyaert, Rudi, Bezbradica, Jelena, Bhaskar, Kiran, Bhatia-Kissova, Ingrid, Bhattacharya, Resham, Bhattacharya, Sujoy, Bhattacharyya, Shalmoli, Bhuiyan, Md Shenuarin, Bhutia, Sujit Kumar, Bi, Lanrong, Bi, Xiaolin, Biden, Trevor, Bijian, Krikor, Billes, Viktor, Binart, Nadine, Bincoletto, Claudia, Birgisdottir, Asa, Bjorkoy, Geir, Blanco, Gonzalo, Blas-Garcia, Ana, Blasiak, Janusz, Blomgran, Robert, Blomgren, Klas, Blum, Janice, Boada-Romero, Emilio, Boban, Mirta, Boesze-Battaglia, Kathleen, Boeuf, Philippe, Boland, Barry, Bomont, Pascale, Bonaldo, Paolo, Bonam, Srinivasa Reddy, Bonfili, Laura, Bonifacino, Juan, Boone, Brian, Bootman, Martin, Bordi, Matteo, Borner, Christoph, Bornhauser, Beat, Borthakur, Gautam, Bosch, Jürgen, Bose, Santanu, botana, luis, Botas, Juan, Boulanger, Chantal, Boulton, Michael, Bourdenx, Mathieu, Bourgeois, Benjamin, Bourke, Nollaig, Bousquet, Guilhem, Boya, Patricia, Bozhkov, Peter, Bozi, Luiz, Bozkurt, Tolga, Brackney, Doug, Brandts, Christian, Braun, Ralf, Braus, Gerhard, Bravo-Sagua, Roberto, Bravo-San Pedro, José, Brest, Patrick, Bringer, Marie-Agnès, Briones-Herrera, Alfredo, Broaddus, V Courtney, Brodersen, Peter, Brodsky, Jeffrey, Brody, Steven, Bronson, Paola, Bronstein, Jeff, Brown, Carolyn, Brown, Rhoderick, Brum, Patricia, Brumell, John, Brunetti-Pierri, Nicola, Bruno, Daniele, Bryson-Richardson, Robert, Bucci, Cecilia, Buchrieser, Carmen, Bueno, Marta, Buitrago-Molina, Laura Elisa, Buraschi, Simone, Buch, Shilpa, Buchan, J Ross, Buckingham, Erin, Budak, Hikmet, Budini, Mauricio, Bultynck, Geert, Burada, Florin, Burgoyne, Joseph, Burón, M Isabel, Bustos, Victor, Büttner, Sabrina, Butturini, Elena, Byrd, Aaron, Cabas, Isabel, Cabrera-Benitez, Sandra, Cadwell, Ken, Cai, Jingjing, Cai, Lu, Cai, Qian, Cairó, Montserrat, Calbet, Jose, Caldwell, Guy, Caldwell, Kim, Call, Jarrod, Calvani, Riccardo, Calvo, Ana, Calvo-Rubio Barrera, Miguel, Camara, Niels OS, Camonis, Jacques, Camougrand, Nadine, Campanella, Michelangelo, Campbell, Edward, Campbell-Valois, François-Xavier, Campello, Silvia, Campesi, Ilaria, Campos, Juliane, Camuzard, Olivier, Cancino, Jorge, Candido de Almeida, Danilo, Canesi, Laura, Caniggia, Isabella, Canonico, Barbara, Cantí, Carles, Cao, Bin, Caraglia, Michele, Caramés, Beatriz, Carchman, Evie, Cardenal-Muñoz, Elena, Cardenas, Cesar, Cardenas, Luis, Cardoso, Sandra, Carew, Jennifer, Carle, Georges, Carleton, Gillian, Carloni, Silvia, Carmona-Gutierrez, Didac, Carneiro, Leticia, Carnevali, Oliana, Carosi, Julian, Carra, Serena, Carrier, Alice, Carrier, Lucie, Carroll, Bernadette, Carter, A Brent, Carvalho, Andreia Neves, Casanova, Magali, Casas, Caty, Casas, Josefina, Cassioli, Chiara, Castillo, Eliseo, Castillo, Karen, Castillo-Lluva, Sonia, Castoldi, Francesca, Castori, Marco, Castro, Ariel, Castro-Caldas, Margarida, Castro-Hernandez, Javier, Castro-Obregon, Susana, Catz, Sergio, Cavadas, Claudia, Cavaliere, Federica, Cavallini, Gabriella, Cavinato, Maria, Cayuela, Maria, Cebollada Rica, Paula, Cecarini, Valentina, Cecconi, Francesco, Cechowska-Pasko, Marzanna, Cenci, Simone, Ceperuelo-Mallafré, Victòria, Cerqueira, João, Cerutti, Janete, Cervia, Davide, Cetintas, Vildan Bozok, Cetrullo, Silvia, Chae, Han-Jung, Chagin, Andrei, Chai, Chee-Yin, Chakrabarti, Gopal, Chakrabarti, Oishee, Chakraborty, Tapas, Chakraborty, Trinad, Chami, mounia, Chamilos, Georgios, Chan, David, Chan, Edmond, Chan, Edward, Chan, H.Y. Edwin, Chan, Helen, Chan, Hung, Chan, Matthew, Chan, Yau Sang, Chandra, Partha, Chang, Chih-Peng, Chang, Chunmei, Chang, Hao-Chun, Chang, Kai, Chao, Jie, Chapman, Tracey, Charlet-Berguerand, Nicolas, Chatterjee, Samrat, Chaube, Shail, Chaudhary, Anu, Chauhan, Santosh, Chaum, Edward, Checler, Frédéric, Cheetham, Michael, Chen, Chang-Shi, Chen, Guang-Chao, Chen, Jian-Fu, Chen, Liam, Chen, Leilei, Chen, Lin, Chen, Mingliang, Chen, Mu-Kuan, Chen, Ning, Chen, Quan, Chen, Ruey-Hwa, Chen, Shi, Chen, Wei, Chen, Weiqiang, Chen, Xin-Ming, Chen, Xiong-Wen, Chen, Xu, Chen, Yan, Chen, Ye-Guang, Chen, Yingyu, Chen, Yongqiang, Chen, Yu-Jen, Chen, Yue-Qin, Chen, Zhefan Stephen, Chen, Zhi, Chen, Zhi-Hua, Chen, Zhijian, Chen, Zhixiang, Cheng, Hanhua, Cheng, Jun, Cheng, Shi-Yuan, Cheng, Wei, Cheng, Xiaodong, Cheng, Xiu-Tang, Cheng, Yiyun, Cheng, Zhiyong, Chen, Zhong, Cheong, Heesun, Cheong, Jit Kong, Chernyak, Boris, Cherry, Sara, Cheung, Chi Fai Randy, Cheung, Chun Hei Antonio, Cheung, King-Ho, Chevet, Eric, Chi, Richard, Chiang, Alan Kwok Shing, Chiaradonna, Ferdinando, Chiarelli, Roberto, Chiariello, Mario, Chica, Nathalia, Chiocca, Susanna, Chiong, Mario, Chiou, Shih-Hwa, Chiramel, Abhilash, Chiurchiù, Valerio, Cho, Dong-Hyung, Choe, Seong-Kyu, Choi, Augustine, Choi, Mary, Choudhury, Kamalika Roy, Chow, Norman, Chu, Charleen, Chua, Jason, Chua, John Jia En, Chung, Hyewon, Chung, Kin Pan, Chung, Seockhoon, Chung, So-Hyang, Chung, Yuen-Li, Cianfanelli, Valentina, Ciechomska, Iwona, Cifuentes, Mariana, Cinque, Laura, Cirak, Sebahattin, Cirone, Mara, Clague, Michael, Clarke, Robert, Clementi, Emilio, Coccia, Eliana, Codogno, Patrice, Cohen, Ehud, Cohen, Mickael, Colasanti, Tania, Colasuonno, Fiorella, Colbert, Robert, Colell, Anna, Čolić, Miodrag, Coll, Nuria, Collins, Mark, Colombo, María, Colón-Ramos, Daniel, Combaret, Lydie, Comincini, Sergio, Cominetti, Márcia, Consiglio, Antonella, Conte, Andrea, Conti, Fabrizio, Contu, Viorica Raluca, Cookson, Mark, Coombs, Kevin, Coppens, Isabelle, Corasaniti, Maria Tiziana, Corkery, Dale, Cordes, Nils, Cortese, Katia, Costa, Maria do Carmo, Costantino, Sarah, Costelli, Paola, Coto-Montes, Ana, Crack, Peter, Crespo, Jose, Criollo, Alfredo, Crippa, Valeria, Cristofani, Riccardo, Csizmadia, Tamas, Cuadrado, Antonio, Cui, Bing, Cui, Jun, Cui, Yixian, Cui, Yong, Culetto, Emmanuel, Cumino, Andrea, Cybulsky, Andrey, Czaja, Mark, Czuczwar, Stanislaw, D'Adamo, Stefania, D'Amelio, Marcello, D'Arcangelo, Daniela, D'Lugos, Andrew, D'Orazi, Gabriella, da Silva, James, Dafsari, Hormos Salimi, Dagda, Ruben, Dagdas, Yasin, Daglia, Maria, Dai, Xiaoxia, Dai, Yun, Dai, Yuyuan, Dal Col, Jessica, Dalhaimer, Paul, Dalla Valle, Luisa, Dallenga, Tobias, Dalmasso, Guillaume, Damme, Markus, Dando, Ilaria, Dantuma, Nico, Darling, April, Das, Hiranmoy, Dasarathy, Srinivasan, Dasari, Santosh, Dash, Srikanta, Daumke, Oliver, Dauphinee, Adrian, Davies, Jeffrey, Dávila, Valeria, Davis, Roger, Davis, Tanja, Dayalan Naidu, Sharadha, De Amicis, Francesca, De Bosscher, Karolien, De Felice, Francesca, De Franceschi, Lucia, De Leonibus, Chiara, de Mattos Barbosa, Mayara, De Meyer, Guido, De Milito, Angelo, De Nunzio, Cosimo, De Palma, Clara, De Santi, Mauro, De Virgilio, Claudio, De Zio, Daniela, Debnath, Jayanta, DeBosch, Brian, Decuypere, Jean-Paul, Deehan, Mark, Deflorian, Gianluca, DeGregori, James, Dehay, Benjamin, Del Rio, Gabriel, Delaney, Joe, Delbridge, Lea, Delorme-Axford, Elizabeth, Delpino, M Victoria, Demarchi, Francesca, Dembitz, Vilma, Demers, Nicholas, Deng, Hongbin, Deng, Zhiqiang, Dengjel, Joern, Dent, Paul, Denton, Donna, DePamphilis, Melvin, Der, Channing, Deretic, Vojo, Descoteaux, Albert, Devis, Laura, Devkota, Sushil, Devuyst, Olivier, Dewson, Grant, Dharmasivam, Mahendiran, Dhiman, Rohan, di Bernardo, Diego, Di Cristina, Manlio, Di Domenico, Fabio, Di Fazio, Pietro, Di Fonzo, Alessio, Di Guardo, Giovanni, Di Guglielmo, Gianni, Di Leo, Luca, Di Malta, Chiara, Di Nardo, Alessia, Di Rienzo, Martina, Di Sano, Federica, Diallinas, George, Diao, Jiajie, Diaz-Araya, Guillermo, Díaz-Laviada, Inés, Dickinson, Jared, Diederich, Marc, Dieudé, Mélanie, Dikic, Ivan, Ding, Shiping, Ding, Wen-Xing, Dini, Luciana, Dinić, Jelena, Dinic, Miroslav, Dinkova-Kostova, Albena, Dionne, Marc, Distler, Jörg, Diwan, Abhinav, Dixon, Ian, Djavaheri-Mergny, Mojgan, Dobrinski, Ina, Dobrovinskaya, Oxana, Dobrowolski, Radek, Dobson, Renwick, Đokić, Jelena, Dokmeci Emre, Serap, Donadelli, Massimo, Dong, Bo, Dong, Xiaonan, Dong, Zhiwu, Dorn Ii, Gerald, Dotsch, Volker, Dou, Huan, Dou, Juan, Dowaidar, Moataz, Dridi, Sami, Drucker, Liat, Du, Ailian, Du, Caigan, Du, Guangwei, Du, Hai-Ning, Du, Li-Lin, du Toit, André, Duan, Shao-Bin, Duan, Xiaoqiong, Duarte, Sónia, Dubrovska, Anna, Dunlop, Elaine, Dupont, Nicolas, Durán, Raúl, Dwarakanath, Bilikere, Dyshlovoy, Sergey, Ebrahimi-Fakhari, Darius, Eckhart, Leopold, Edelstein, Charles, Efferth, Thomas, Eftekharpour, Eftekhar, Eichinger, Ludwig, Eid, Nabil, Eisenberg, Tobias, Eissa, N Tony, Eissa, Sanaa, Ejarque, Miriam, El Andaloussi, Abdeljabar, El-Hage, Nazira, El-Naggar, Shahenda, Eleuteri, Anna Maria, El-Shafey, Eman, Elgendy, Mohamed, Eliopoulos, Aristides, Elizalde, María, Elks, Philip, Elsasser, Hans-Peter, Elsherbiny, Eslam, Emerling, Brooke, Emre, N., Eng, Christina, Engedal, Nikolai, Engelbrecht, Anna-Mart, Engelsen, Agnete, Enserink, Jorrit, Escalante, Ricardo, Esclatine, Audrey, Escobar-Henriques, Mafalda, Eskelinen, Eeva-Liisa, Espert, Lucile, Eusebio, Makandjou-Ola, Fabrias, Gemma, Fabrizi, Cinzia, Facchiano, Antonio, Facchiano, Francesco, Fadeel, Bengt, Fader, Claudio, Faesen, Alex, Fairlie, W Douglas, Falcó, Alberto, Falkenburger, Bjorn, Fan, Daping, Fan, Jie, Fan, Yanbo, Fang, Evandro, Fang, Yanshan, Fang, Yognqi, Fanto, Manolis, Farfel-Becker, Tamar, Faure, Mathias, Fazeli, Gholamreza, Fedele, Anthony, Feldman, Arthur, Feng, Du, Feng, Jiachun, Feng, Lifeng, Feng, Yibin, Feng, Yuchen, Feng, Wei, Fenz Araujo, Thais, Ferguson, Thomas, Fernández, Álvaro, Fernandez-Checa, Jose, Fernández-Veledo, Sonia, Fernie, Alisdair, Ferrante, Anthony, Ferraresi, Alessandra, Ferrari, Merari, Ferreira, Julio, Ferro-Novick, Susan, Figueras, Antonio, Filadi, Riccardo, Filigheddu, Nicoletta, Filippi-Chiela, Eduardo, Filomeni, Giuseppe, Fimia, Gian Maria, Fineschi, Vittorio, Finetti, Francesca, Finkbeiner, Steven, Fisher, Edward, Fisher, Paul, Flamigni, Flavio, Fliesler, Steven, Flo, Trude, Florance, Ida, Florey, Oliver, Florio, Tullio, Fodor, Erika, Follo, Carlo, Fon, Edward, Forlino, Antonella, Fornai, Francesco, Fortini, Paola, Fracassi, Anna, Fraldi, Alessandro, Franco, Brunella, Franco, Rodrigo, Franconi, Flavia, Frankel, Lisa, Friedman, Scott, Fröhlich, Leopold, Frühbeck, Gema, Fuentes, Jose, Fujiki, Yukio, Fujita, Naonobu, Fujiwara, Yuuki, Fukuda, Mitsunori, Fulda, Simone, Furic, Luc, Furuya, Norihiko, Fusco, Carmela, Gack, Michaela, Gaffke, Lidia, Galadari, Sehamuddin, Galasso, Alessia, Galindo, Maria, Gallolu Kankanamalage, Sachith, Galluzzi, Lorenzo, Galy, Vincent, Gammoh, Noor, Gan, Boyi, Ganley, Ian, Gao, Feng, Gao, Hui, Gao, Minghui, Gao, Ping, Gao, Shou-Jiang, Gao, Wentao, Gao, Xiaobo, Garcera, Ana, Garcia, Maria Noé, Garcia, Verónica, García-del Portillo, Francisco, Garcia-Escudero, Vega, Garcia-Garcia, Aracely, Garcia-Macia, Marina, García-Moreno, Diana, Garcia-Ruiz, Carmen, García-Sanz, Patricia, Garg, Abhishek, Gargini, Ricardo, Garofalo, Tina, Garry, Robert, Gassen, Nils, Gatica, Damian, Ge, Liang, Ge, Wanzhong, Geiss-Friedlander, Ruth, Gelfi, Cecilia, Genschik, Pascal, Gentle, Ian, Gerbino, Valeria, Gerhardt, Christoph, Germain, Kyla, Germain, Marc, Gewirtz, David, Ghasemipour Afshar, Elham, Ghavami, Saeid, Ghigo, Alessandra, Ghosh, Manosij, Giamas, Georgios, Giampietri, Claudia, Giatromanolaki, Alexandra, Gibson, Gary, Gibson, Spencer, Ginet, Vanessa, Giniger, Edward, Giorgi, Carlotta, Girao, Henrique, Girardin, Stephen, Giridharan, Mridhula, Giuliano, Sandy, Giulivi, Cecilia, Giuriato, Sylvie, Giustiniani, Julien, Gluschko, Alexander, Goder, Veit, Goginashvili, Alexander, Golab, Jakub, Goldstone, David, Golebiewska, Anna, Gomes, Luciana, Gomez, Rodrigo, Gómez-Sánchez, Rubén, Gomez-Puerto, Maria Catalina, Gomez-Sintes, Raquel, Gong, Qingqiu, Goni, Felix, González-Gallego, Javier, Gonzalez-Hernandez, Tomas, Gonzalez-Polo, Rosa, Gonzalez-Reyes, Jose, González-Rodríguez, Patricia, Goping, Ing Swie, Gorbatyuk, Marina, Gorbunov, Nikolai, Görgülü, Kıvanç, Gorojod, Roxana, Gorski, Sharon, Goruppi, Sandro, Gotor, Cecilia, Gottlieb, Roberta, Gozes, Illana, Gozuacik, Devrim, Graef, Martin, Gräler, Markus, Granatiero, Veronica, Grasso, Daniel, Gray, Joshua, Green, Douglas, Greenhough, Alexander, Gregory, Stephen, Griffin, Edward, Grinstaff, Mark, Gros, Frederic, Grose, Charles, Gross, Angelina, Gruber, Florian, Grumati, Paolo, Grune, Tilman, Gu, Xueyan, Guan, Jun-Lin, Guardia, Carlos, Guda, Kishore, Guerra, Flora, Guerri, Consuelo, Guha, Prasun, Guillén, Carlos, Gujar, Shashi, Gukovskaya, Anna, Gukovsky, Ilya, Gunst, Jan, Günther, Andreas, Guntur, Anyonya, Guo, Chuanyong, Guo, Chun, Guo, Hongqing, Guo, Lian-Wang, Guo, Ming, Gupta, Pawan, Gupta, Shashi Kumar, Gupta, Swapnil, Gupta, Veer Bala, Gupta, Vivek, Gustafsson, Asa, Gutterman, David, H B, Ranjitha, Haapasalo, Annakaisa, Haber, James, Hać, Aleksandra, Hadano, Shinji, Hafrén, Anders, Haidar, Mansour, Hall, Belinda, Halldén, Gunnel, Hamacher-Brady, Anne, Hamann, Andrea, Hamasaki, Maho, Han, Weidong, Hansen, Malene, Hanson, Phyllis, Hao, Zijian, Harada, Masaru, Harhaji-Trajkovic, Ljubica, Hariharan, Nirmala, Haroon, Nigil, Harris, James, Hasegawa, Takafumi, Hasima Nagoor, Noor, Haspel, Jeffrey, Haucke, Volker, Hawkins, Wayne, Hay, Bruce, Haynes, Cole, Hayrabedyan, Soren, Hays, Thomas, He, Congcong, He, Qin, He, Rong-Rong, He, You-Wen, He, Yu-Ying, Heakal, Yasser, Heberle, Alexander, Hejtmancik, J Fielding, Helgason, Gudmundur Vignir, Henkel, Vanessa, Herb, Marc, Hergovich, Alexander, Herman-Antosiewicz, Anna, Hernández, Agustín, Hernandez, Carlos, Hernandez-Diaz, Sergio, Hernandez-Gea, Virginia, Herpin, Amaury, Herreros, Judit, Hervás, Javier, Hesselson, Daniel, Hetz, Claudio, Heussler, Volker, Higuchi, Yujiro, Hilfiker, Sabine, Hill, Joseph, Hlavacek, William, Ho, Emmanuel, Ho, Idy, Ho, Philip Wing-Lok, Ho, Shu-Leong, Ho, Wan Yun, Hobbs, G Aaron, Hochstrasser, Mark, Hoet, Peter, Hofius, Daniel, Hofman, Paul, Höhn, Annika, Holmberg, Carina, Hombrebueno, Jose, Yi-Ren Hong, Chang-Won Hong, Hooper, Lora, Hoppe, Thorsten, Horos, Rastislav, Hoshida, Yujin, Hsin, I-Lun, Hsu, Hsin-Yun, Hu, Bing, Hu, Dong, Hu, Li-Fang, Hu, Ming Chang, Hu, Ronggui, Hu, Wei, Hu, Yu-Chen, Hu, Zhuo-Wei, Hua, Fang, Hua, Jinlian, Hua, Yingqi, Huan, Chongmin, Huang, Canhua, Huang, Chuanshu, Huang, Chuanxin, Huang, Chunling, Huang, Haishan, Huang, Kun, Huang, Michael, Huang, Rui, Huang, Shan, Huang, Tianzhi, Huang, Xing, Huang, Yuxiang Jack, Huber, Tobias, Hubert, Virginie, Hubner, Christian, Hughes, Stephanie, Hughes, William, Humbert, Magali, Hummer, Gerhard, Hurley, James, Hussain, Sabah, Hussain, Salik, Hussey, Patrick, Hutabarat, Martina, Hwang, Hui-Yun, Hwang, Seungmin, Ieni, Antonio, Ikeda, Fumiyo, Imagawa, Yusuke, Imai, Yuzuru, Imbriano, Carol, Imoto, Masaya, Inman, Denise, Inoki, Ken, Iovanna, Juan, Iozzo, Renato, Ippolito, Giuseppe, Irazoqui, Javier, Iribarren, Pablo, Ishaq, Mohd, ISHIKAWA, Makoto, Ishimwe, Nestor, Isidoro, Ciro, Ismail, Nahed, Issazadeh-Navikas, Shohreh, Itakura, Eisuke, Ito, Daisuke, Ivankovic, Davor, Ivanova, Saška, Iyer, Anand Krishnan V, Izquierdo, José, Izumi, Masanori, Jäättelä, Marja, Jabir, Majid Sakhi, Jackson, William, Jacobo-Herrera, Nadia, Jacomin, Anne-Claire, Jacquin, Elise, Jadiya, Pooja, Jaeschke, Hartmut, Jagannath, Chinnaswamy, Jakobi, Arjen, Jakobsson, Johan, Janji, Bassam, Jansen-Dürr, Pidder, Jansson, Patric, Jantsch, Jonathan, Januszewski, Sławomir, Jassey, Alagie, Jean, Steve, Jeltsch-David, Hélène, Jendelova, Pavla, Jenny, Andreas, Jensen, Thomas, Jessen, Niels, Jewell, Jenna, Ji, Jing, Jia, Lijun, Jia, Rui, Jiang, Liwen, Jiang, Qing, Jiang, Richeng, Jiang, Teng, Jiang, Xuejun, Jiang, Yu, Jimenez-Sanchez, Maria, Jin, Eun-Jung, Jin, Fengyan, Jin, Hongchuan, Jin, Li, Jin, Luqi, Jin, Meiyan, Jin, Si, Jo, Eun-Kyeong, Joffre, Carine, Johansen, Terje, Johnson, Gail, Johnston, Simon, Jokitalo, Eija, Jolly, Mohit Kumar, Joosten, Leo, Jordan, Joaquin, Joseph, Bertrand, Ju, Dianwen, Ju, Jeong-Sun, Ju, Jingfang, Juárez, Esmeralda, Judith, Delphine, Juhász, Gábor, Jun, Youngsoo, Jung, Chang Hwa, Jung, Sung-Chul, Jung, Yong Keun, Jungbluth, Heinz, Jungverdorben, Johannes, Just, Steffen, Kaarniranta, Kai, Kaasik, Allen, Kabuta, Tomohiro, Kaganovich, Daniel, Kahana, Alon, Kain, Renate, Kajimura, Shinjo, Kalamvoki, Maria, Kalia, Manjula, Kalinowski, Danuta, Kaludercic, Nina, Kalvari, Ioanna, Kaminska, Joanna, Kaminskyy, Vitaliy, Kanamori, Hiromitsu, Kanasaki, Keizo, Kang, Chanhee, Kang, Rui, Kang, Sang Sun, Kaniyappan, Senthilvelrajan, Kanki, Tomotake, Kanneganti, Thirumala-Devi, Kanthasamy, Anumantha, Kanthasamy, Arthi, Kantorow, Marc, Kapuy, Orsolya, Karamouzis, Michalis, Karim, Md Razaul, Karmakar, Parimal, Katare, Rajesh, Kato, Masaru, Kaufmann, Stefan, Kauppinen, Anu, Kaushal, Gur, Kaushik, Susmita, Kawasaki, Kiyoshi, Kazan, Kemal, Ke, Po-Yuan, Keating, Damien, Keber, Ursula, Kehrl, John, Keller, Kate, Keller, Christian, Kemper, Jongsook Kim, Kenific, Candia, Kepp, Oliver, Kermorgant, Stephanie, Kern, Andreas, Ketteler, Robin, Keulers, Tom, Khalfin, Boris, Khalil, Hany, Khambu, Bilon, Khan, Shahid, Khandelwal, Vinoth Kumar Megraj, Khandia, Rekha, Kho, Widuri, Khobrekar, Noopur, Khuansuwan, Sataree, Khundadze, Mukhran, Killackey, Samuel, Kim, Dasol, Kim, Deok Ryong, Kim, Do-Hyung, Kim, Dong-Eun, Kim, Eun Young, Kim, Eun-Kyoung, Kim, Hak-Rim, Kim, Hee-Sik, Kim, Hyung Ryong, Kim, Jeong Hun, Kim, Jin Kyung, Kim, Jin-Hoi, Kim, Joungmok, Kim, Ju Hwan, Kim, Keun Il, Kim, Peter, Kim, Seong-Jun, Kimball, Scot, Kimchi, 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Kazuyuki, Kuenen, Sabine, Kuerschner, Lars, Kukar, Thomas, Kumar, Ajay, Kumar, Ashok, Kumar, Deepak, Kumar, Dhiraj, Kumar, Sharad, Kume, Shinji, Kumsta, Caroline, Kundu, Chanakya, Kundu, Mondira, Kunnumakkara, Ajaikumar, Kurgan, Lukasz, Kutateladze, Tatiana, Kutlu, Ozlem, Kwak, SeongAe, Kwon, Ho Jeong, Kwon, Taeg Kyu, Kwon, Yong Tae, Kyrmizi, Irene, La Spada, Albert, Labonté, Patrick, Ladoire, Sylvain, Laface, Ilaria, Lafont, Frank, Lagace, Diane, Lahiri, Vikramjit, Lai, Zhibing, Laird, Angela, Lakkaraju, Aparna, Lamark, Trond, Lan, Sheng-Hui, Landajuela, Ane, Lane, Darius, Lane, Jon, Lang, Charles, Lange, Carsten, Langel, Ülo, Langer, Rupert, Lapaquette, Pierre, Laporte, Jocelyn, LaRusso, Nicholas, Lastres-Becker, Isabel, Lau, Wilson Chun Yu, Laurie, Gordon, Lavandero, Sergio, Law, Betty Yuen Kwan, Law, Helen Ka-wai, Layfield, Rob, Le, Weidong, Le Stunff, Herve, Leary, Alexandre, Lebrun, Jean-Jacques, Leck, Lionel, Leduc-Gaudet, Jean-Philippe, Lee, Changwook, Lee, Chung-Pei, Lee, 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Chengyu, Liang, Qiangrong, Liang, Weicheng, Liang, Yongheng, Liang, YongTian, Liao, Guanghong, Liao, Lujian, Liao, Mingzhi, Liao, Yung-Feng, Librizzi, Mariangela, Lie, Pearl, Lilly, Mary, Lim, Hyunjung, Lima, Thania, Limana, Federica, Lin, Chao, Lin, Chih-Wen, Lin, Dar-Shong, Lin, Fu-Cheng, Lin, Jiandie, Lin, Kurt, Lin, Kwang-Huei, Lin, Liang-Tzung, LIN, Pei-Hui, Lin, Qiong, Lin, Shaofeng, Lin, Su-Ju, Lin, Wenyu, Lin, Xueying, Lin, Yao-Xin, Lin, Yee-Shin, Linden, Rafael, Lindner, Paula, Ling, Shuo-Chien, Lingor, Paul, Linnemann, Amelia, Liou, Yih-Cherng, Lipinski, Marta, Lipovšek, Saška, Lira, Vitor, Lisiak, Natalia, Liton, Paloma, Liu, Chao, Liu, Ching-Hsuan, Liu, Chun-Feng, Liu, Cui Hua, Liu, Fang, Liu, Hao, Liu, Hsiao-Sheng, Liu, Hua-feng, Liu, Huifang, Liu, Jia, Liu, Jing, Liu, Julia, Liu, Leyuan, Liu, Longhua, Liu, Meilian, Liu, Qin, Liu, Wei, Liu, Wende, Liu, Xiao-Hong, Liu, Xiaodong, Liu, Xingguo, Liu, Xu, Liu, Xuedong, Liu, Yanfen, Liu, Yang, Liu, Yueyang, Liu, Yule, 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Elena, Uchiyama, Yasuo, Ugun-Klusek, Aslihan, Uhlig, Holm, Ułamek-Kozioł, Marzena, Ulasov, Ilya, Umekawa, Midori, Ungermann, Christian, Unno, Rei, Urbe, Sylvie, Uribe-Carretero, Elisabet, Üstün, Suayib, Uversky, Vladimir, Vaccari, Thomas, Vaccaro, Maria, Vahsen, Björn, Vakifahmetoglu-Norberg, Helin, Valdor, Rut, Valente, Maria, Valko, Ayelén, Vallee, Richard, Valverde, Angela, Van Den Berghe, Greet, van der Veen, Stijn, Van Kaer, Luc, van Loosdregt, Jorg, van Wijk, Sjoerd, Vandenberghe, Wim, Vanhorebeek, Ilse, Vannier-Santos, Marcos, Vannini, Nicola, Vanrell, M Cristina, Vantaggiato, Chiara, Varano, Gabriele, Varela-Nieto, Isabel, Varga, Máté, Vasconcelos, M Helena, Vats, Somya, Vavvas, Demetrios, Vega-Naredo, Ignacio, Vega-Rubin-de-Celis, Silvia, Velasco, Guillermo, Velázquez, Ariadna, Vellai, Tibor, Vellenga, Edo, Velotti, Francesca, Verdier, Mireille, Verginis, Panayotis, Vergne, Isabelle, Verkade, Paul, Verma, Manish, Verstreken, Patrik, Vervliet, Tim, Vervoorts, Jörg, Vessoni, Alexandre, Victor, Victor, Vidal, Michel, Vidoni, Chiara, Vieira, Otilia, Vierstra, Richard, Viganó, Sonia, Vihinen, Helena, Vijayan, Vinoy, Vila, Miquel, Vilar, Marçal, Villalba, José, Villalobo, Antonio, Villarejo-Zori, Beatriz, Villarroya, Francesc, Villarroya, Joan, Vincent, Olivier, Vindis, Cecile, Viret, Christophe, Viscomi, Maria Teresa, Visnjic, Dora, Vitale, Ilio, Vocadlo, David, Voitsekhovskaja, Olga, Volonté, Cinzia, Volta, Mattia, Vomero, Marta, Von Haefen, Clarissa, Vooijs, Marc, Voos, Wolfgang, Vucicevic, Ljubica, Wade-Martins, Richard, Waguri, Satoshi, Waite, Kenrick, Wakatsuki, Shuji, Walker, David, Walker, Mark, Walker, Simon, Walter, Jochen, Wandosell, Francisco, Wang, Bo, Wang, Chao-Yung, Wang, Chen, Wang, Chenran, Wang, Chenwei, Wang, Cun-Yu, Wang, Dong, Wang, Fangyang, Wang, Feng, Wang, Fengming, Wang, Guansong, Wang, Han, Wang, Hao, Wang, Hexiang, Wang, Hong-Gang, Wang, Jianrong, Wang, Jigang, Wang, Jiou, Wang, Jundong, Wang, Kui, Wang, Lianrong, Wang, Liming, Wang, Maggie Haitian, Wang, Meiqing, Wang, Nanbu, Wang, PengWei, Wang, PeiPei, Wang, Ping, Wang, Qing Jun, Wang, Qing, Wang, Qing Kenneth, Wang, Qiong, Wang, Wen-Tao, Wang, Wuyang, Wang, Xinnan, Wang, Xuejun, Wang, Yan, Wang, Yanchang, Wang, Yanzhuang, Wang, Yen-Yun, Wang, Yihua, Wang, Yipeng, Wang, Yu, wang, yuqi, Wang, Zhe, Wang, Zhenyu, Wang, Zhouguang, Warnes, Gary, Warnsmann, Verena, Watada, Hirotaka, Watanabe, Eizo, Watchon, Maxinne, Wawrzyńska, Anna, Weaver, Timothy, Wegrzyn, Grzegorz, Wehman, Ann, Wei, Huafeng, Wei, Lei, Wei, Taotao, Wei, Yongjie, Weiergräber, Oliver, Weihl, Conrad, Weindl, Günther, Weiskirchen, Ralf, Wells, Alan, Wen, Runxia, Wen, Xin, Werner, Antonia, Weykopf, Beatrice, Wheatley, Sally, Whitton, J Lindsay, Whitworth, Alexander, Wiktorska, Katarzyna, Wildenberg, Manon, Wileman, Tom, Wilkinson, Simon, Willbold, Dieter, Williams, Brett, Williams, Robin, Williams, Roger, Williamson, Peter, Wilson, Richard, Winner, Beate, Winsor, Nathaniel, Witkin, Steven, Wodrich, Harald, Woehlbier, Ute, Wollert, Thomas, Wong, Esther, Wong, Jack Ho, Wong, Richard, Wong, Vincent Kam Wai, Wong, W Wei-Lynn, Wu, An-Guo, Wu, Chengbiao, Wu, Jian, Wu, Junfang, Wu, Kenneth, Wu, Min, Wu, Shan-Ying, Wu, Shengzhou, Wu, Shu-Yan, Wu, Shufang, Wu, William, Wu, Xiaohong, Wu, Xiaoqing, Wu, Yao-Wen, Wu, Yihua, Xavier, Ramnik, Xia, Hongguang, Xia, Lixin, Xia, Zhengyuan, Xiang, Ge, Xiang, Jin, Xiang, Mingliang, Xiang, Wei, Xiao, Bin, Xiao, Guozhi, Xiao, Hengyi, Xiao, Hong-tao, Xiao, Jian, Xiao, Lan, Xiao, Shi, Xiao, Yin, Xie, Baoming, Xie, Chuan-Ming, Xie, Min, Xie, Yuxiang, Xie, Zhiping, Xie, Zhonglin, Xilouri, Maria, Xu, Congfeng, Xu, En, Xu, Haoxing, Xu, Jing, Xu, Jinrong, Xu, Liang, Xu, Wen Wen, Xu, Xiulong, Xue, Yu, Yakhine-Diop, Sokhna, Yamaguchi, Masamitsu, Yamaguchi, Osamu, Yamamoto, Ai, Yamashina, Shunhei, Yan, Shengmin, Yan, Shian-Jang, Yan, Zhen, Yanagi, Yasuo, Yang, Chuanbin, Yang, Dun-Sheng, Yang, Huan, Yang, Huang-Tian, Yang, Hui, Yang, Jin-Ming, Yang, Jing, Yang, Jingyu, Yang, Ling, Yang, Liu, Yang, Ming, Yang, Pei-Ming, Yang, Qian, Yang, Seungwon, Yang, Shu, Yang, Shun-Fa, Yang, Wannian, Yang, Wei Yuan, Yang, Xiaoyong, Yang, Xuesong, Yang, Yi, Yang, Ying, Yao, Honghong, Yao, Shenggen, Yao, Xiaoqiang, Yao, Yong-Gang, Yao, Yong-Ming, Yasui, Takahiro, Yazdankhah, Meysam, Yen, Paul, Yi, Cong, Yin, Xiao-Ming, Yin, Yanhai, Yin, Zhangyuan, Yin, Ziyi, Ying, Meidan, Ying, Zheng, Yip, Calvin, Yiu, Stephanie Pei Tung, Yoo, Young, Yoshida, Kiyotsugu, Yoshii, Saori, Yoshimori, Tamotsu, Yousefi, Bahman, Yu, Boxuan, Yu, Haiyang, Yu, Jun, Yu, Li, Yu, Ming-Lung, Yu, Seong-Woon, Yu, Victor, Yu, W Haung, Yu, Zhengping, Yu, Zhou, Yuan, Junying, Yuan, Ling-Qing, Yuan, Shilin, Yuan, Shyng-Shiou, Yuan, Yanggang, Yuan, Zengqiang, Yue, Jianbo, Yue, Zhenyu, Yun, Jeanho, Yung, Raymond, Zacks, David, Zaffagnini, Gabriele, Zambelli, Vanessa, Zanella, Isabella, Zang, Qun, Zanivan, Sara, Zappavigna, Silvia, Zaragoza, Pilar, Zarbalis, Konstantinos, Zarebkohan, Amir, Zarrouk, Amira, Zeitlin, Scott, Zeng, Jialiu, Zeng, Ju-deng, Žerovnik, Eva, Zhan, Lixuan, Zhang, Bin, Zhang, Donna, Zhang, Hanlin, Zhang, Hong, Zhang, Honghe, Zhang, Huafeng, Zhang, Huaye, Zhang, Hui, Zhang, Hui-Ling, Zhang, Jianbin, Zhang, Jianhua, Zhang, Jing-Pu, Zhang, Kalin, Zhang, Leshuai, Zhang, Lin, Zhang, Lisheng, Zhang, Lu, Zhang, Luoying, Zhang, Menghuan, Zhang, Peng, Zhang, Sheng, Zhang, Wei, Zhang, Xiangnan, Zhang, Xiao-Wei, Zhang, Xiaolei, Zhang, Xiaoyan, Zhang, Xin, Zhang, Xinxin, Zhang, Xu Dong, Zhang, Yang, Zhang, Yanjin, Zhang, Yi, Zhang, Ying-Dong, Zhang, Yingmei, Zhang, Yuan-Yuan, Zhang, Yuchen, Zhang, Zhe, Zhang, Zhengguang, Zhang, Zhibing, Zhang, Zhihai, Zhang, Zhiyong, Zhang, Zili, Zhao, Haobin, Zhao, Lei, Zhao, Shuang, Zhao, Tongbiao, Zhao, Xiao-Fan, Zhao, Ying, Zhao, Yongchao, Zhao, Yongliang, Zhao, Yuting, Zheng, Guoping, Zheng, Kai, Zheng, Ling, Zheng, Shizhong, Zheng, Xi-Long, Zheng, Yi, Zheng, Zu-Guo, Zhivotovsky, Boris, Zhong, Qing, Zhou, Ao, Zhou, Ben, Zhou, Cefan, ZHOU, Gang, Zhou, Hao, Zhou, Hong, Zhou, Hongbo, Zhou, Jie, Zhou, Jing, Zhou, Jiyong, Zhou, Kailiang, Zhou, Rongjia, Zhou, Xu-jie, Zhou, Yanshuang, Zhou, Yinghong, Zhou, Yubin, Zhou, Zheng-Yu, Zhou, Zhou, Zhu, Binglin, Zhu, Changlian, Zhu, Guo-Qing, Zhu, Haining, Zhu, Hongxin, Zhu, Hua, Zhu, Wei-Guo, Zhu, Yanping, Zhu, Yushan, Zhuang, Haixia, Zhuang, Xiaohong, Zientara-Rytter, Katarzyna, Zimmermann, Christine, Ziviani, Elena, Zoladek, Teresa, Zong, Wei-Xing, Zorov, Dmitry, Zorzano, Antonio, Zou, Weiping, Zou, Zhen, Zou, Zhengzhi, Zuryn, Steven, Zwerschke, Werner, Brand-Saberi, Beate, Dong, X Charlie, Kenchappa, Chandra Shekar, Li, Zuguo, Lin, Yong, Oshima, Shigeru, Rong, Yueguang, Sluimer, Judith, Stallings, Christina, Tong, Chun-Kit, Ahmad, S. Tariq, Alim Al-Bari, M. Abdul, Bechara, Luiz R.G., Behrens, Georg M.N., Bhuiyan, Md. Shenuarin, Broaddus, V. Courtney, Buchan, J. Ross, Burón, M. Isabel, Carter, A. Brent, Chan, Matthew T.V., Choi, Augustine M.K., D’Adamo, Stefania, D’Amelio, Marcello, D’Arcangelo, Daniela, D’Lugos, Andrew, D’Orazi, Gabriella, De Meyer, Guido R.Y., Delpino, M. Victoria, Distler, Jörg H.W., Dixon, Ian M.C., Dobson, Renwick C.J., 2nd Dorn, Gerald, Eissa, N. Tony, Engelsen, Agnete S.T., Fairlie, W. Douglas, Ferreira, Julio C.B., H.B., Ranjitha, Hanson, Phyllis I., Hejtmancik, J. Fielding, Ho, Idy H.T., Hobbs, G. Aaron, Hoet, Peter H.M., Huang, Michael L.H., Iyer, Anand Krishnan V., Johnson, Gail V.W., Joosten, Leo A.B., Karim, Md. Razaul, Kaufmann, Stefan H.E., Ko, Ben C.B., Leck, Lionel Y.W., Lima, Thania R.R., Livingston, J. Andrew, Martin, Alexandre P.J., Montes, L. Ruth, Murphy, J. Patrick, Ng, Charlene C.W., Nicolao, M. Celeste, O’Donovan, Tracey, O’Leary, Seónadh, O’Rourke, Eyleen, O’Sullivan, Mary, O’Sullivan, Timothy, Omary, M. Bishr, Pereira, Gustavo J.S., Ratnayaka, J. Arjuna, Riazuddin, S. Amer, Rouschop, Kasper M.A., Sanderson, J. Thomas, Scaglione, K. Matthew, Schapira, Anthony H.V., Scovassi, A. Ivana, St. Clair, Daret, Sunahara, Karen K.S., Symons, J. David, Triola, Gemma, van Wijk, Sjoerd J.L., Vanrell, M. Cristina, Vasconcelos, M. Helena, Whitton, J. Lindsay, Williams, Robin S.B., Wong, W. Wei-Lynn, Wu, William K.K., Yakhine-Diop, Sokhna M.S., Yu, W. Haung, Zhang, Kalin Y.B., Dong, X. Charlie, Ain Shams University [ASU], Johannes Gutenberg - Universität Mainz = Johannes Gutenberg University [JGU], Medical University Graz, Centre de Recherche des Cordeliers [CRC (UMR_S_1138 / U1138)], Institut Pasteur d'Iran, Leibniz Institute of Plant Biochemistry [IPB], The University of Texas M.D. Anderson Cancer Center [Houston], Institut de pharmacologie moléculaire et cellulaire [IPMC], Lipides - Nutrition - Cancer [Dijon - U1231] [LNC], Centre méditerranéen de médecine moléculaire [C3M], Institut de Biologie Valrose [IBV], Petites Molécules de neuroprotection, neurorégénération et remyélinisation, Signalisation Hormonale, Physiopathologie Endocrinienne et Métabolique, Institut Cochin [IC UM3 (UMR 8104 / U1016)], Institut NeuroMyoGène [INMG], Paris-Centre de Recherche Cardiovasculaire [PARCC (UMR_S 970/ U970)], Marqueurs cardiovasculaires en situation de stress [MASCOT (UMR_S_942 / U942)], Institut de Recherche sur le Cancer et le Vieillissement [IRCAN], Centre de Recherche en Cancérologie de Marseille [CRCM], Centre for Integrative Biology - CBI [Inserm U964 - CNRS UMR7104 - IGBMC], Oncogenesis, Stress, Signaling [OSS], Institut Necker Enfants-Malades [INEM - UM 111 (UMR 8253 / U1151)], Institut de Biologie Intégrative de la Cellule [I2BC], Microbes, Intestin, Inflammation et Susceptibilité de l'Hôte [M2iSH], Centre de Recherches en Cancérologie de Toulouse [CRCT], Physiopathologie et traitement des maladies du foie, Centre d’Infection et d’Immunité de Lille - INSERM U 1019 - UMR 9017 - UMR 8204 [CIIL], Institut de Génétique et de Biologie Moléculaire et Cellulaire [IGBMC], Laboratoire Bio-PeroxIL. Biochimie du peroxysome, inflammation et métabolisme lipidique [Dijon] [BIO-PEROXIL], Centre de recherche sur l'Inflammation [CRI (UMR_S_1149 / ERL_8252 / U1149)], Unité de génétique et biologie des cancers [U830], Laboratoire d'Optique et Biosciences [LOB], Institut des Maladies Métaboliques et Casdiovasculaires [UPS/Inserm U1297 - I2MC], Différenciation et communication neuronale et neuroendocrine [DC2N], Institut de Recherche en Cancérologie de Montpellier [IRCM - U1194 Inserm - UM], Centre d'Immunologie de Marseille - Luminy [CIML], Physiopathologie et imagerie des troubles neurologiques [PhIND], Laboratory of Fundamental and Applied Bioenergetics = Laboratoire de bioénergétique fondamentale et appliquée [LBFA], Imagine - Institut des maladies génétiques (IHU) [Imagine - U1163], Institut Mondor de Recherche Biomédicale [IMRB], Franco-czech Laboratory for clinical research on obesity, University of Michigan [Ann Arbor], University of Michigan System, Institut de pharmacologie moléculaire et cellulaire (IPMC), Centre National de la Recherche Scientifique (CNRS)-Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015 - 2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015 - 2019) (COMUE UCA)-Université Côte d'Azur (UCA), Lipides - Nutrition - Cancer [Dijon - U1231] (LNC), Université de Bourgogne (UB)-Institut National de la Santé et de la Recherche Médicale (INSERM)-AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement, Centre méditerranéen de médecine moléculaire (C3M), Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015 - 2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015 - 2019) (COMUE UCA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Côte d'Azur (UCA), Institut de Biologie Valrose (IBV), COMUE Université Côte d'Azur (2015 - 2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015 - 2019) (COMUE UCA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Côte d'Azur (UCA)-Centre National de la Recherche Scientifique (CNRS), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Sud - Paris 11 (UP11), Centre de Recherche des Cordeliers (CRC (UMR_S_1138 / U1138)), École pratique des hautes études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Université de Paris (UP), Université Paris-Sud - Paris 11 (UP11)-Institut National de la Santé et de la Recherche Médicale (INSERM)-AP-HP Hôpital Bicêtre (Le Kremlin-Bicêtre), Nutrition, Métabolisme, Aquaculture (NuMéA), Université de Pau et des Pays de l'Adour (UPPA)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Institut Cochin (IC UM3 (UMR 8104 / U1016)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), Institut NeuroMyoGène (INMG), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM), Paris-Centre de Recherche Cardiovasculaire (PARCC - UMR-S U970), Hôpital Européen Georges Pompidou [APHP] (HEGP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Paris (UP), Institut de Recherche sur le Cancer et le Vieillissement (IRCAN), COMUE Université Côte d'Azur (2015 - 2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015 - 2019) (COMUE UCA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Côte d'Azur (UCA), Centre des Sciences du Goût et de l'Alimentation [Dijon] (CSGA), Université de Bourgogne (UB)-AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Université Bourgogne Franche-Comté [COMUE] (UBFC), Centre de Recherche en Cancérologie de Marseille (CRCM), Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut Paoli-Calmettes, Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Aix Marseille Université (AMU), Centre for Integrative Biology - CBI (Inserm U964 - CNRS UMR7104 - IGBMC), Université de Strasbourg (UNISTRA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institute of genetics and molecular and cellular biology-Centre National de la Recherche Scientifique (CNRS), Chemistry, Oncogenesis, Stress and Signaling (COSS), Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-CRLCC Eugène Marquis (CRLCC)-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut Necker Enfants-Malades (INEM - UM 111 (UMR 8253 / U1151)), Unité de Nutrition Humaine (UNH), Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Clermont Auvergne (UCA), Institut de Biologie Intégrative de la Cellule (I2BC), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Microbes, Intestin, Inflammation et Susceptibilité de l'Hôte (M2iSH), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre de Recherche en Nutrition Humaine d'Auvergne (CRNH d'Auvergne)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Clermont Auvergne (UCA), Institut des Maladies Neurodégénératives [Bordeaux] (IMN), Université de Bordeaux (UB)-Centre National de la Recherche Scientifique (CNRS), Centre International de Recherche en Infectiologie - UMR (CIRI), École normale supérieure - Lyon (ENS Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Centre de Recherches en Cancérologie de Toulouse (CRCT), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Physiologie et Génomique des Poissons (LPGP), Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay, Centre d’Infection et d’Immunité de Lille - INSERM U 1019 - UMR 9017 - UMR 8204 (CIIL), Institut Pasteur de Lille, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille)-Centre National de la Recherche Scientifique (CNRS), Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA), Laboratoire Bio-PeroxIL. Biochimie du peroxysome, inflammation et métabolisme lipidique [Dijon] (BIO-PEROXIL), Université de Bourgogne (UB)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Bourgogne Franche-Comté [COMUE] (UBFC), Centre de recherche sur l'Inflammation (CRI (UMR_S_1149 / ERL_8252 / U1149)), Institut Jean-Pierre Bourgin (IJPB), AgroParisTech-Université Paris-Saclay-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Unité de génétique et biologie des cancers (U830), Institut Curie [Paris]-Institut National de la Santé et de la Recherche Médicale (INSERM), Laboratoire d'Optique et Biosciences (LOB), École polytechnique (X)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Institut des Maladies Métaboliques et Cardiovasculaires (I2MC), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM), Différenciation et communication neuronale et neuroendocrine (DC2N), Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut de Recherche en Cancérologie de Montpellier (IRCM - U1194 Inserm - UM), CRLCC Val d'Aurelle - Paul Lamarque-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM), Centre d'Immunologie de Marseille - Luminy (CIML), Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Physiopathologie et imagerie des troubles neurologiques (PhIND), Université de Caen Normandie (UNICAEN), Laboratory of Fundamental and Applied Bioenergetics = Laboratoire de bioénergétique fondamentale et appliquée (LBFA), Université Grenoble Alpes (UGA)-Institut National de la Santé et de la Recherche Médicale (INSERM), Epithelial biology and disease - Liliane Bettencourt Chair of Developmental Biology (Equipe Inserm U1163), Imagine - Institut des maladies génétiques (IHU) (Imagine - U1163), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Paris (UP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Paris (UP), Biomécanique cellulaire et respiratoire (BCR), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12)-Centre National de la Recherche Scientifique (CNRS), Charles University [Prague]-Institut National de la Santé et de la Recherche Médicale (INSERM), This work was supported by the National Institute of General Medical Sciences [GM131919]., Université Paris-Sud - Paris 11 (UP11)-Institut National de la Santé et de la Recherche Médicale (INSERM), Marqueurs cardiovasculaires en situation de stress (MASCOT (UMR_S_942 / U942)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Groupe Hospitalier Saint Louis - Lariboisière - Fernand Widal [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP)-Université Sorbonne Paris Nord, Université de Strasbourg (UNISTRA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Physiopathologie des Adaptations Nutritionnelles (PhAN), Université de Nantes (UN)-Institut National de la Recherche Agronomique (INRA), Département Plateforme (PF I2BC), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Institut Gustave Roussy (IGR), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO), Chinese Academy of Medical Sciences [Suzhou, Chine] (CAMS), Karolinska Institutet [Stockholm], Karolinska University Hospital [Stockholm], Department of Women's and Children's Health [Stockholm, Sweden], Centre National de la Recherche Scientifique (CNRS)-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille)-Université de Lille-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut Pasteur de Lille, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP), Université de Strasbourg (UNISTRA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-École polytechnique (X), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées, FHU OncoAge - Pathologies liées à l’âge [CHU Nice] (OncoAge), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Côte d'Azur (UCA)-Institut de Pharmacologie Moléculaire et Cellulaire [UNIV Côte d'Azur] (UPMC), Institut Universitaire du Cancer de Toulouse - Oncopole (IUCT Oncopole - UMR 1037), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-CHU Toulouse [Toulouse]-Institut National de la Santé et de la Recherche Médicale (INSERM), Life Sciences Institute [Ann Arbor, MI, USA], University of Michigan System-University of Michigan System, European Institute of Oncology IRCCS [Milan, Italy] (EIO), Ain Shams University (ASU), Johannes Gutenberg - Universität Mainz = Johannes Gutenberg University (JGU), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Université Paris Cité (UPCité), Réseau International des Instituts Pasteur (RIIP), Leibniz Institute of Plant Biochemistry (IPB), Hebrew University of Jerusalem, Université Nice Sophia Antipolis (1965 - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Centre National de la Recherche Scientifique (CNRS)-Université Côte d'Azur (UCA), Université de Bourgogne (UB)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut Agro Dijon, Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Côte d'Azur (UCA), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Côte d'Azur (UCA), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Paris-Centre de Recherche Cardiovasculaire (PARCC (UMR_S 970/ U970)), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité)-Université Sorbonne Paris Nord, Aix Marseille Université (AMU)-Institut Paoli-Calmettes, Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Oncogenesis, Stress, Signaling (OSS), Institut des Maladies Métaboliques et Casdiovasculaires (UPS/Inserm U1297 - I2MC), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Grenoble Alpes (UGA), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité), Institut Mondor de Recherche Biomédicale (IMRB), Institut National de la Santé et de la Recherche Médicale (INSERM)-IFR10-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), Charles University [Prague] (CU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Klionsky, D. 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D., Zhang, H., Zhang, H. -L., Zhang, J., Zhang, J. -P., Zhang, K. Y. B., Zhang, L. W., Zhang, L., Zhang, M., Zhang, P., Zhang, S., Zhang, W., Zhang, X., Zhang, X. -W., Zhang, X. D., Zhang, Y., Zhang, Y. -D., Zhang, Y. -Y., Zhang, Z., Zhao, H., Zhao, L., Zhao, S., Zhao, T., Zhao, X. -F., Zhao, Y., Zheng, G., Zheng, K., Zheng, L., Zheng, S., Zheng, X. -L., Zheng, Y., Zheng, Z. -G., Zhivotovsky, B., Zhong, Q., Zhou, A., Zhou, B., Zhou, C., Zhou, G., Zhou, H., Zhou, J., Zhou, K., Zhou, R., Zhou, X. -J., Zhou, Y., Zhou, Z. -Y., Zhou, Z., Zhu, B., Zhu, C., Zhu, G. -Q., Zhu, H., Zhu, W. -G., Zhu, Y., Zhuang, H., Zhuang, X., Zientara-Rytter, K., Zimmermann, C. M., Ziviani, E., Zoladek, T., Zong, W. -X., Zorov, D. B., Zorzano, A., Zou, W., Zou, Z., Zuryn, S., Zwerschke, W., Brand-Saberi, B., Dong, X. C., Kenchappa, C. S., Lin, Y., Oshima, S., Rong, Y., Sluimer, J. C., Stallings, C. L., Tong, C. -K., and Centre National de la Recherche Scientifique (CNRS)
Subjects: 0301 basic medicine, Programmed cell death, Settore BIO/06, Autophagosome, Autolysosome, [SDV]Life Sciences [q-bio], lnfectious Diseases and Global Health Radboud Institute for Molecular Life Sciences [Radboudumc 4], Autophagy-Related Proteins, Review, Computational biology, [SDV.BC]Life Sciences [q-bio]/Cellular Biology, Biology, Settore MED/04, 03 medical and health sciences, stress, Chaperone-mediated autophagy, ddc:570, Autophagy, LC3, Animals, Humans, cancer, Settore BIO/10, flux, lysosome, macroautophagy, neurodegeneration, phagophore, vacuole, Set (psychology), Molecular Biology, 030102 biochemistry & molecular biology, business.industry, Interpretation (philosophy), Autophagosomes, Cell Biology, Multicellular organism, 030104 developmental biology, Knowledge base, Biological Assay, Lysosomes, business, Biomarkers, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Abstract: Contains fulltext : 232759.pdf (Publisher’s version ) (Closed access) In 2008, we published the first set of guidelines for standardizing research in autophagy. Since then, this topic has received increasing attention, and many scientists have entered the field. Our knowledge base and relevant new technologies have also been expanding. Thus, it is important to formulate on a regular basis updated guidelines for monitoring autophagy in different organisms. Despite numerous reviews, there continues to be confusion regarding acceptable methods to evaluate autophagy, especially in multicellular eukaryotes. Here, we present a set of guidelines for investigators to select and interpret methods to examine autophagy and related processes, and for reviewers to provide realistic and reasonable critiques of reports that are focused on these processes. These guidelines are not meant to be a dogmatic set of rules, because the appropriateness of any assay largely depends on the question being asked and the system being used. Moreover, no individual assay is perfect for every situation, calling for the use of multiple techniques to properly monitor autophagy in each experimental setting. Finally, several core components of the autophagy machinery have been implicated in distinct autophagic processes (canonical and noncanonical autophagy), implying that genetic approaches to block autophagy should rely on targeting two or more autophagy-related genes that ideally participate in distinct steps of the pathway. Along similar lines, because multiple proteins involved in autophagy also regulate other cellular pathways including apoptosis, not all of them can be used as a specific marker for bona fide autophagic responses. Here, we critically discuss current methods of assessing autophagy and the information they can, or cannot, provide. Our ultimate goal is to encourage intellectual and technical innovation in the field.
Published: 2021
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21. Thalassemia Is Paradoxically Associated with a Reduced Risk of In-Hospital Complications and Mortality in COVID-19: Data from an International Registry

Author: Ibrahim El-Battrawy, Elisa De Michele, Manuela Balocco, Immacolata Tartaglione, Carmelo Fidone, Roberto Lisi, Maria Caterina Putti, Marcos Garca-Aguado, Michela Ribersani, Ramón Arroyo-Espliguero, Vicente Estrada, Lucia De Franceschi, Maurizio Miano, Antonella Massa, Alessandra Quota, Vincenzo Voi, Monica Fortini, Maria Domenica Cappellini, Inmaculada Fernández-Rozas, Marco Marziali, Giovanna Graziadei, Angelantonio Vitucci, Alberto Piperno, Iván Núñez Gil Md, Irene Motta, Wulandewi Marhaeni, Marco Zecca, Maddalena Casale, Antonio Piga, Silverio Perrotta, Bryan Rupinski, Charbel Maroun, Filomena Longo, Rodolfo Romero, R. Mariani, Domenico Roberti, Susanna Barella, Andrea Beccaria, Valeria Pinto, Barbara Gianesin, Mohammad Abumayyaleh, Rosamaria Rosso, Carolina Espejo Paeres, Álvaro Aparisi, Gian Luca Forni, Rita Gamberini, Ibrahim Akin, Anna Rita Denotti, Federico Bonetti, Alessia Marcon, El-Battrawy, Ibrahim, Longo, Filomena, Núñez Gil, Iván J, Abumayyaleh, Mohammad, Gianesin, Barbara, Estrada, Vicente, Aparisi, Álvaro, Arroyo-Espliguero, Ramón, Balocco, Manuela, Barella, Susanna, Beccaria, Andrea, Bonetti, Federico, Casale, Maddalena, De Michele, Elisa, Denotti, Anna Rita, Fidone, Carmelo, Fortini, Monica, Gamberini, Maria Rita, Graziadei, Giovanna, Lisi, Roberto, Massa, Antonella, Marcon, Alessia, Rubinski, Bryan, Miano, Maurizio, Motta, Irene, Pinto, Valeria Maria, Piperno, Alberto, Mariani, Raffaella, Putti, Maria Caterina, Quota, Alessandra, Ribersani, Michela, Marziali, Marco, Roberti, Domenico, Rosso, Rosamaria, Tartaglione, Immacolata, Vitucci, Angelantonio, Voi, Vincenzo, Zecca, Marco, Romero, Rodolfo, Marouneld, Charbel, Fernández-Rozas, Inmaculada, Espejo, Carolina, Marhaeni, Wulandewi, Garcia Aguado, Marco, Cappellini, Maria Domenica, Perrotta, Silverio, De Franceschi, Lucia, Piga, Antonio, Forni, Gian Luca, and Akin, Ibrahim
Subjects: Male, Pediatrics, medicine.medical_specialty, Iron Overload, Thalassemia, medicine.medical_treatment, Splenectomy, thalassaemia, Disease, law.invention, law, medicine, Humans, Registries, Continuous positive airway pressure, COVID-19, SARS-CoV-2, mortality, business.industry, Acute kidney injury, Cell Biology, medicine.disease, Intensive care unit, Hospitals, Oxygen, Cohort, Molecular Medicine, Female, business, Kidney disease
Abstract: Background: Although numerous patient specific co-factors have been shown to be associated with worse outcomes in COVID-19, the prognostic value of thalasemic syndromes in COVID-19 patients remains poorly understood. Aims: We studied the outcomes of 137 COVID-19 patients with a history of Transfusion Dependent Thalassemia (TDT) and non-Transfusion Dependent Thalassemia (NTDT) extracted from a large international cohort and compared them with the outcomes from a matched cohort of COVID-19 patients with no history of thalasemia. Results: The mean age of thalassemia patients included in our study was 41±16 years (48.9% male). Almost 81% of these patients suffered from TDT requiring blood transfusions on a regular basis. 38.7% of patients were blood group O. Cardiac iron overload was documented in 6.8% of study patients, whereas liver iron overload was documented in 35% of study patients. 25% of thalassemia patients had a history of splenectomy. 27.7% of study patients required hospitalization due to COVID-19 infection. Amongst the hospitalized patients, one patient died (0.7%) and one patient required intubation. Continuous positive airway pressure (CPAP) was required in almost 5% of study patients. After adjustment for age-, sex- and other known risk factors (cardiac disease, kidney disease and pulmonary disease), the rate of in-hospital complications (supplemental oxygen use, admission to the an intensive care unit for CPAP therapy or intubation) and all-cause mortality was significantly lower in the thalassemia group compared to the matched cohort with no history of thalassemia. Amongst thalassemia patients in general, the NTDT group exhibited a higher rate of hospitalization compared to the TDT group (p=0.001). In addition, the rate of complications such as acute kidney injury and need for supplemental oxygen was significantly higher in the NTDT group compared to the TDT group. In the multivariable logistic regression analysis, age and history of heart or kidney disease were all found to be independent risk factors for increased in-hospital, all-cause mortality, whereas the presence of thalassemia (either TDT or NTDT) was found to be independently associated with reduced all-cause mortality. Conclusions: The presence of thalassemia in COVID-19 patients was independently associated with lower in-hospital, all-cause mortality and few in-hospital complications in in our study. The pathophysiology of this is unclear and needs to be studied in vitro and in animal models. Trial Registration for sources of data extraction: NCT: 04334291, 04746066 Funding Statement: This study was funded by a non-conditioned grant from FUNDACION INTERHOSPITALARIA PARA LA INVESTIGACION CARDIOVASCULAR, FIC. (Madrid, Spain). This nonprofit institution had no role in the study design, the collection, analysis and interpretation of data, the writing of the report, or the decision to submit the paper for publication. Declaration of Interests: The authors declare no conflicts of interest. Ethics Approval Statement: The study was approved by the Ethics Committees in all of the centers involved (Banjarmasin, Bari, Cagliari, Catania, Ferrara, Gela, Genoa, Getafe, Guadalajara, Legan, Madrid, Mannheim, Milan, Monza, Naples, Olbia, Padua, Pavia, Ragusa, Rome, Salerno, Turin, Valladolid and Verona).
Published: 2021
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22. Radiation testing of a commercial 6-axis MEMS inertial navigation unit at ENEA Frascati proton linear accelerator

Author: F. Cardelli, L. Piersanti, Emiliano Trinca, Marco Sabatini, F. Fortini, Vincenzo Surrenti, Giovanni B. Palmerini, Monia Vadrucci, G. Bazzano, Paolo Nenzi, Luigi Picardi, Concetta Ronsivalle, A. Ampollini, Bazzano, G., Ampollini, A., Cardelli, F., Fortini, F., Nenzi, P., Palmerini, G. B., Picardi, L., Piersanti, L., Ronsivalle, C., Surrenti, V., Trinca, E., Vadrucci, M., and Sabatini, M.
Subjects: Atmospheric Science, 010504 meteorology & atmospheric sciences, Computer science, COTS, Aerospace Engineering, radiation hardness, 01 natural sciences, Linear particle accelerator, law.invention, law, Inertial measurement unit, 0103 physical sciences, Aerospace engineering, 010303 astronomy & astrophysics, Radiation hardening, Inertial navigation system, 0105 earth and related environmental sciences, business.industry, Navigation system, Astronomy and Astrophysics, Particle accelerator, Gyroscope, IMU, MEMS, Geophysics, Space and Planetary Science, Absorbed dose, proton, General Earth and Planetary Sciences, business
Abstract: We present the first results of a novel collaboration activity between ENEA Frascati Particle Accelerator Laboratory and University La Sapienza Guidance and Navigation Laboratory in the field of Radiation Hardness Assurance (RHA) for space applications. The aim of this research is twofold: (a) demonstrating the possibility to use the TOP-IMPLART proton accelerator for radiation hardness assurance testing, developing ad hoc dosimetric and operational procedures for RHA irradiations; (b) investigating system level radiation testing strategies for Commercial Off The Shelf (COTS) components of interest for SmallSats space missions, with focus on devices and sensors of interest for guidance, navigation and control, through simultaneous exploration of Total Ionizing Dose (TID), Displacement Damage (DD) dose and Single-Event Effects (SEE) with proton beams. A commercial 6-axis integrated Micro Electro-Mechanical Systems (MEMS) inertial navigation system (accelerometer, gyroscope) was selected as first Device Under Test (DUT). The results of experimental tests aimed to define an operational procedure and the characterization of radiation effects on the component are reported, highlighting the consequence of the device performance degradation in terms of the overall navigation system accuracy. Doses up to 50 krad(Si) were probed and cross sections for Single-Event Functional Interrupt (SEFI) evaluated at a proton energy of 30 MeV.
Published: 2021

23. Course and Lethality of SARS-CoV-2 Epidemic in Nursing Homes after Vaccination in Florence, Italy

Author: Claudia Cosma, Andrea Ungar, Eleonora Barghini, Cecilia Piga, Giulia Bandini, Paolo Carrai, Chiara Lorini, Serena Boni, Gabriele Vaccaro, Sante Giardini, Ilaria Del Lungo, Giancarlo Landini, Primo Buscemi, Letizia Martella, Aldo Lo Forte, Simone Pupo, Enrico Mossello, Daniela Balzi, Antonio Faraone, Giulia Rivasi, Enrico Benvenuti, Riccardo Barucci, Giulia Bulli, Lorenzo Stacchini, Andrea Crociani, Giacomo Fortini, Salvatore Gangemi, Irene Marozzi, M. Bulgaresi, Guglielmo Bonaccorsi, and L. Baggiani
Subjects: medicine.medical_specialty, 2019-20 coronavirus outbreak, Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), Immunology, Death risk, Article, lethality, Vaccination status, Internal medicine, vaccine, Drug Discovery, Medicine, Pharmacology (medical), older adults, Pharmacology, nursing home residents, business.industry, Mortality rate, COVID-19, Mean age, mortality, Vaccination, Infectious Diseases, hospitalization, business, Nursing homes, COVID‐19
Abstract: Evidence on the effectiveness of SARS-CoV-2 vaccines in nursing home (NHs) residents is limited. We examined the impact of the BNT162b2 mRNA SARS-CoV-2 vaccine on the course of the epidemic in NHs in the Florence Health District, Italy, before and after vaccination. Moreover, we assessed survival and hospitalization by vaccination status in SARS-CoV-2-positive cases occurring during the post-vaccination period. We calculated the weekly infection rates during the pre-vaccination (1 October–26 December 2020) and post-vaccination period (27 December 2020–31 March 2021). Cox analysis was used to analyze survival by vaccination status. The study involved 3730 residents (mean age 84, 69% female). Weekly infection rates fluctuated during the pre-vaccination period (1.8%–6.5%) and dropped to zero during the post-vaccination period. Nine unvaccinated (UN), 56 partially vaccinated (PV) and 35 fully vaccinated (FV) residents tested SARS-CoV-2+ during the post-vaccination period. FV showed significantly lower hospitalization and mortality rates than PV and UV (hospitalization: FV 3%, PV 14%, UV 33%; mortality: FV 6%, PV 18%, UV 56%). The death risk was 84% and 96% lower in PV (HR 0.157, 95%CI 0.049–0.491) and FV (HR 0.037, 95%CI 0.006–0.223) versus UV. SARS-CoV-2 vaccination was followed by a marked decline in infection rates and was associated with lower morbidity and mortality among infected NH residents.
Published: 2021

24. Benefits in pain perception, ability function and health-related quality of life in patients with failed back surgery syndrome undergoing spinal cord stimulation in a clinical practice setting

Author: Gianpaolo Fortini, Lorenzo G. Mantovani, Laura Demartini, P. Poli, Paolo Cortesi, Marisa De Rose, V. Menardo, Enrico De Simone, P Cozzolino, Luciana Scalone, A. Costantini, Furio Zucco, Angelo Lavano, Mario Meglio, Scalone, L, Zucco, F, Lavano, A, Costantini, A, De Rose, M, Poli, P, Fortini, G, Demartini, L, De Simone, E, Menardo, V, Meglio, M, Cozzolino, P, Cortesi, P, and Mantovani, L
Subjects: Male, medicine.medical_specialty, Activities of daily living, Population, Spinal cord stimulation, Pain intensity, lcsh:Computer applications to medicine. Medical informatics, Health-related quality-of-life, 03 medical and health sciences, 0302 clinical medicine, Quality of life, Rating scale, Activities of Daily Living, medicine, Pain perception, Humans, 030212 general & internal medicine, education, Aged, Health related quality of life, education.field_of_study, Disability, business.industry, Research, Public Health, Environmental and Occupational Health, Peripheral Nervous System Diseases, Pain Perception, General Medicine, Middle Aged, humanities, Oswestry Disability Index, Treatment Outcome, Physical therapy, Quality of Life, lcsh:R858-859.7, Female, Peripheral Nervous System Disease, Failed back surgery syndrome, business, 030217 neurology & neurosurgery, Human
Abstract: Background Failed back surgery syndrome (FBSS) represents one main cause of chronic neuropathic or mixed pain, functional disability and reduced Health Related Quality of Life (HRQoL). Spinal Cord Stimulation (SCS) can be a value for money option to treat patients refractory to conventional medical management (CMM). We estimated from real-world data: 1) the amount of reduced levels of HRQoL of target patients compared to general population, 2) the relationship between pain intensity, functional disability, and overall HRQoL, and 3) the improvement of patients’ health from SCS intervention, and 4) we give some insights and make some suggestions on the selection of a battery of patients’ reported health instruments for use in routine clinical practice. Methods At recruitment (before SCS) and every 6 months for 2 years after SCS a battery of questionnaires/tests were completed: the generic EQ-5D and SF-36 for HRQoL, the specific Numerical Rating Scale (NRS) to measure pain intensity, and Oswestry Disability Index (ODI) to measure functional disability. We conducted multilevel regression analyses to investigate the association of HRQoL with the NRS and ODI indexes; multiple regression analyses to compare EQ-5D data with those of the general population adjusted for age, sex and education, and statistical tests to compare the changes of HRQoL, NRS and ODI estimates at baseline with those measured during the follow-up. Results Eighty patients (40% male, mean age = 58 years) participated. HRQoL was significantly worse in the patients than in the corresponding general population. Pain, functional disability and HRQoL significantly related each other during follow-up, Significant improvements (p
Published: 2018
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25. Ophthalmologists perceived usefulness of Patient Health Questionnaire (PHQ-9) and Generalized Anxiety Disorder (GAD-7) for evaluating the mental health of patients with chronic eye diseases

Author: Anwar Ahmed, Silvio P Mariotti, Sami Al Shahwan, Samar A Al-Swailem, Stefania Fortini, and Rajiv Khandekar
Subjects: medicine.medical_specialty, Generalized anxiety disorder, Eye Diseases, Ophthalmologists, business.industry, Depression, General Medicine, Patient Health Questionnaire, medicine.disease, Mental health, Anxiety Disorders, Ophthalmology, Mental Health, medicine, Humans, Psychiatry, business
Abstract: Purpose: To evaluate the awareness of ophthalmologists about assessing the mental health of patients and usefulness of the Patient Health Questionnaire (PHQ-9) and Generalized Anxiety Disorder (GAD-7) survey. Methods: This web-based survey was performed in 2020 at an eye hospital in Saudi Arabia. Participants included ophthalmologists and physicians. Participants were queried on the need to assess mental health of patients, usefulness of the screening tool, and barriers to assessment. Their responses were graded on a Likert scale and Rasch analysis was performed. Results: Of the 100 participants, 72 were aware of assessing mental health of eye patients and 82 expressed about limited skills for such assessment. The median score for perceived usefulness of the PHQ-9 as screening tool to suspect depression was −1.0 (inter quartile range, −1.0: 0.0) [Mean Rasch score = −0.735]. The median score of perceived usefulness for the GAD-7 as screening tool to suspect anxiety was −1.0 (inter quartile range, −1.0: 0.0) [Mean Rasch score = −0.695]. The PHQ-9 related score was significantly correlated to “30–39 years” age group (Kruskal Wallis p = 0.04) and non-Saudi professionals (Mann Whitney p = 0.005). The GAD-7 related score was significantly correlated to non-Saudi professionals (Mann Whitney p = 0.04). The mental health related score was significantly and negatively correlated to the “40–59 years” age group (Kruskal Wallis p = 0.04). Conclusions: Although awareness of mental health assessment was high, eyecare professionals felt with inadequate training for performing the screening. PHQ-9 seems to be more acceptable to screen for depression than GAD-7 for screening anxiety.
Published: 2021

26. Atomic Layer Deposition and Chemical Vapor Deposition of Multipactor Suppression Coatings

Author: Chris Oldham, Art Fortini, and R. Lawrence
Subjects: Materials science, business.industry, Chemical vapor deposition, Plasma, Atomic layer deposition, Sputtering, visual_art, visual_art.visual_art_medium, Optoelectronics, Neutron, Radio frequency, Ceramic, business, Spallation Neutron Source
Abstract: The U.S. Department of Energy is looking for improved multipactor suppression coatings for high power, low frequency, RF windows. Specifically, robust uniform coatings are required for 402 MHz, pillbox windows for the Spallation Neutron Source. Coatings applied with traditional sputtering are exhibiting non-uniformity and lack of robust adhesion. These RF window use ceramics exceeding twenty inches in diameter. Calabazas Creek Research, Inc. (CCR), in collaboration with Vapor Pulse Technologies and Ultramet, is investigating Atomic Layer Deposition (ALD) and Chemical Vapor Deposition (CVD) to uniformly coat large surfaces.
Published: 2021
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27. Effects of Hydroxychloroquine on endOthelial function in eLDerly with sleep apnea (HOLD): study protocol for a randomized clinical trial

Author: Bruna Eibel, Gustavo Waclawovsky, Maria Claudia Irigoyen, Liliana Fortini Cavalheiro Boll, Antonio Lasalvia Cortes, Leticia Maria Tedesco Silva, Denis Martinez, Beatriz Juliana Caye Rossi, and Sandro Cadaval Gonçalves
Subjects: Medicine (General), medicine.medical_specialty, Heart disease, Population, Medicine (miscellaneous), law.invention, Coronary artery disease, Study Protocol, R5-920, Randomized controlled trial, law, Internal medicine, medicine, Pharmacology (medical), Endothelial dysfunction, education, education.field_of_study, business.industry, Sleep apnea, Hydroxychloroquine, Endothelial function, medicine.disease, Rheumatoid arthritis, Cardiology, business, medicine.drug
Abstract: Background Sleep apnea and coronary artery disease are prevalent and relevant diseases. The mechanism by which sleep apnea leads to coronary artery disease remains unclear. Intermittent hypoxia, caused by sleep apnea, leads to inflammation and consequent endothelial dysfunction. Endothelial dysfunction precedes the development of atherosclerotic disease and the occurrence of cardiovascular events. Agents that potentially act to improve endothelial function can help prevent cardiovascular events. Patients using immunomodulators due to rheumatic diseases have a lower prevalence of cardiovascular diseases. However, the potential cardioprotective effect of these drugs in patients without autoimmune diseases is not clear. Hydroxychloroquine (HCQ) is an immunomodulator used to treat rheumatoid arthritis and systemic lupus erythematosus. In addition to its anti-inflammatory properties, HCQ reduces cholesterol and blood glucose levels and has antithrombotic effects. The drug is inexpensive and widely available. Adverse effects of HCQ are rare and occur more frequently with high doses. Objective In this randomized clinical trial, the effect of HCQ treatment on endothelial function will be tested in seniors with sleep apnea. Methods We will recruit participants over the age of 65 and with moderate-severe sleep apnea from an ongoing cohort. We chose to use this sample already evaluated for sleep apnea for reasons of convenience, but also because the elderly with sleep apnea are vulnerable to heart disease. Endothelial function will be assessed by examining flow-mediated dilation of the brachial artery, the gold standard method, considered an independent predictor of cardiovascular events in the general population and by peripheral arterial tonometry, the most recent and most easily obtained method. Hydroxychloroquine will be used at a dose of 400 mg/daily for 8 weeks. Discussion Our study aims to obtain evidence, albeit preliminary, of the efficacy of hydroxychloroquine in improving endothelial function and reducing cardiovascular risk markers. If the improvement occurs, we plan to design a randomized multicenter clinical trial to confirm the findings. Trial registration ClinicalTrials.gov NCT04161339. Registered on November 2019.
Published: 2021

28. More than one self-limited epilepsy of childhood in the same patient: A multicenter study

Author: Alberto Espeche, Ricardo Cersósimo, Santiago Chacon, Lorena Fasulo, Sebastian Fortini, Adolfo Gallo, Marcos Semprino, Javier Adi, Roberto Caraballo, Santiago Galicchio, Beatriz Gamboni, and Pedro Cachia
Subjects: Male, Pediatrics, medicine.medical_specialty, Adolescent, Occipital epilepsy, Status epilepticus, Epilepsy, Childhood absence epilepsy, Status Epilepticus, medicine, Humans, Childhood seizure, Child, Retrospective Studies, Slow sleep, business.industry, Epileptic encephalopathy, Electroencephalography, medicine.disease, Neurology, Multicenter study, Epilepsy, Absence, Child, Preschool, Female, Neurology (clinical), Epilepsies, Partial, medicine.symptom, business
Abstract: Objective We describe the evolution of the electroclinical picture of patients with different types of self-limited epilepsy of childhood (SLEC) occurring at the same or at different times with or without atypical evolutions as well as patients with SLEC associated with childhood absence epilepsy (CAE). Material and methods A multicenter, retrospective, descriptive study was conducted evaluating patients with SLEC who had focal seizures of different types of SLEC including atypical evolutions as well as SLEC associated with absence epilepsy seen at eight Argentinian centers between April 2000 and April 2019. Of 7705 patients with SLEC, aged between 2 and 14 years (mean, 7.5 years), of whom 2013 were female and 5692 male (ratio, 1:2.8), 5068 patients had SLECTS, 2260 patients had self-limited childhood occipital epilepsy Panayiotopoulos type (SLE-P), 356 had self-limited childhood occipital epilepsy Gastaut type (SLE-G), and 21 had self-limited epilepsy with affective seizures (SLEAS). Electroclinical features typical of more than one SLEC syndrome were recognized in 998 (13 %) children. Results We recognized three well-defined groups of patients. The most frequent association was SLE-P and SLECTS, the paradigmatic type, but associations of SLE-P and SLE-G, SLECTS and SLE-G, and SLEAS and SLE-P or SLECTS were also recognized. The second-most-common association was SLEC and an atypical evolution. In this group, the most frequent combination was SLECTS with its atypical evolution, opercular status epilepticus, epileptic encephalopathy with continuous spike‐and‐waves during slow sleep, or Landau-Kleffner syndrome. SLE-P and SLE-G associated with an atypical evolution were also identified. The third, less-frequent group had SLECTS, SLE-P, or SLE-G associated with CAE. These cases support the concept that the different types of SLEC are part of a self-limited childhood seizure susceptibility syndrome. Conclusion Our study demonstrated that 13 % of our patients with SLEC have with different types of SLEC occurring at the same or at different times with or without atypical evolutions - i.e. CSWSS - as well as patients with SLEC associated with CAE, supporting the concept of the self-limited childhood seizure susceptibility syndrome.
Published: 2021

29. Standing and walking age in children with idiopathic clubfoot: French physiotherapy versus Ponseti method

Author: V. Fortini, Camilla Bettuzzi, Manuele Lampasi, Caterina Novella Abati, E. Prato, S. Di Giacinto, Alessandro Zanardi, and Giada Salvatori
Subjects: 030222 orthopedics, medicine.medical_specialty, Clubfoot, business.industry, Idiopathic clubfoot, Gross motor skill, medicine.disease, Ponseti method, 03 medical and health sciences, 0302 clinical medicine, 030225 pediatrics, Pediatrics, Perinatology and Child Health, Physical therapy, medicine, Orthopedics and Sports Medicine, business, Motor skill
Abstract: Purpose A mild delay in gross motor milestones and walking age has been reported in infants with clubfoot. The influence of different treatments on motor development has been poorly investigated. Some parents and physical therapists express concern that the Ponseti method (PM) and its constraints (abduction brace, casts) would affect development more than the French physical therapy method (FM) due to greater immobilization and lesser stimulation. The purpose of this study was to evaluate achievement of three motor milestones (pull-to-standing, cruising and independent walking) in two groups of clubfoot patients treated at two experienced institutes respectively with the PM and FM. Methods In all, 52 consecutive infants (full-term at birth, mean age at beginning of treatment 24.3 days (sd 10), mean Dimeglio score 12 (sd 3.4)) were prospectively enrolled (26 patients per centre) and followed up to walking age recording milestones. Results The two groups were not different in terms of age at the beginning of treatment (p = 0.067) and rate of tenotomy. Age at tenotomy was significantly lower in the PM group (p = 0.000). Severity (p = 0.004) and number of bilateral cases (p = 0.012) were higher in the PM group. A non-significant difference was found for age of achievement of pull-to-standing (p = 0.109), cruising (p = 0.253) and independent ambulation (p = 0.349) between the two groups. Overall, milestones were achieved approximately two months later than normal population. Sex, severity, laterality and need of tenotomy were not found to significantly influence milestones. Conclusion Our results confirmed that infants with clubfoot are expected to have a minimum delay in motor development. Infants treated with the PM and those treated with the FM did not show significant differences in gross motor milestones achievement at walking age. Level of Evidence Level II – Prospective comparative therapeutic studies
Published: 2019
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30. Suitability of commercially available POC-CCA tests for schistosomiasis: Considerations for efficiency, reproducibility and decision making criteria for field application in areas of low endemicity

Author: Paulo Marcos Zech Coelho, Aureo Almeida, Naftale Katz, Flavia Fernanda Bubula Couto, Maria Luysa C Pedrosa, and Rafaella Fortini Queiroz Grenfell
Subjects: Adult, Male, 0301 basic medicine, Adolescent, Point-of-care testing, Decision Making, Immunology, Schistosomiasis, Kappa index, Young Adult, 03 medical and health sciences, 0302 clinical medicine, parasitic diseases, Statistics, medicine, Humans, Immunology and Allergy, Child, Eggs per gram, Aged, Glycoproteins, Aged, 80 and over, Reproducibility, business.industry, Reproducibility of Results, Helminth Proteins, Middle Aged, medicine.disease, Schistosomiasis mansoni, 030104 developmental biology, Point-of-Care Testing, Antigens, Helminth, Child, Preschool, cardiovascular system, Female, business, 030215 immunology
Abstract: Background Point of care tests would be valuable for field diagnosis. However, high sensitivity will likely be required in low endemicity sets where individuals with low schistosome burden are hard to diagnose. Methods Commercially available POC tests (POC-CCA® and Urine CCA (Schisto) ECO Teste®) were evaluated to evidence their potential in low endemicity areas. Individuals with 0–76 eggs per gram of feces were selected, and comparison was performed between Kato-Katz, Saline Gradient and POC-CCA® after urine concentration (POC FLT) methods. Results Both POC-CCA had poor performances, showing low identification of less than half of positive individuals and several undiagnosed cases, revealing an accuracy of 0.44 and 0.46, and a Kappa Index of 0.308 and 0, respectively. Positivity rates of POC-CCA tests were below the one found for a single Kato-Katz slide. POC FLT had a Kappa Index of 0.617, an accuracy of 0.81, 67% of reproducibility, and was shown to have the same sensitivity of 21 Kato-Katz slides when two tests were performed. Conclusions POC-CCA® and POC Eco presented exactly the same inadequacy in low endemicity areas. POC FLT significantly improved the performance of POC-CCA®. More accurate methods must be evaluated in low endemicity areas.
Published: 2019
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31. Impacts of the hydrological potential change on the energy matrix of the Brazilian State of Minas Gerais: A case study

Author: Fidéllis B.G. L. e Estanislau, Ângela Fortini, Antonella L. Costa, and Leonardo B. Melo
Subjects: Renewable Energy, Sustainability and the Environment, business.industry, Natural resource economics, 020209 energy, Fossil fuel, Climate change, 02 engineering and technology, Energy planning, Renewable energy, Water resources, Hydroelectricity, Greenhouse gas, 0202 electrical engineering, electronic engineering, information engineering, Environmental science, business, Hydropower
Abstract: The vulnerability of electric potential generation from water resources has been evidenced due to uncertainties of climatic origin and energy planning. Changes in rainfall regimes are multifactorial phenomena difficult to model. Rainfall is the main natural way of restoring the reservoir levels of hydroelectric power plants. The reduction in rainfall levels may increase in the coming years, resulting in a probable change of the energy matrix configuration of the state of Minas Gerais (MG). This could reduce the share of renewable sources increasing dependence on the importance of energy from fossil fuels, which are the immediate primary sources of energy available. Prior examinations have portrayed the depletion of hydroelectricity in Brazil, or its macro-regions, however this work tries to supply a more focused look at the effects on the electricity and social sectors of the state of Minas Gerais. The study developed in this paper aims to investigate the hydrological potential alteration impacts and consequences on the energy matrix of the state, the greenhouse gas emissions and the social reflexes of these changes due to scenarios motivated by climate change. The investigation intends to show the importance of the water-energy-emissions nexus for energy planning and decision-making, in order to evaluate the best options for dealing with adverse and potentially destabilizing conditions. The results of the analyses show that while hydropower demand was 5.24 Mtoe in 2015, in 2030 the supply of hydropower will be 5.81 Mtoe and 4.72 Mtoe, for the conservative and severe scenarios, respectively. In addition, the effect of climate change may require an increase in the share of non-renewable sources in the energy matrix, which could increase CO2e emissions from 4.2% to 7.4% by 2030, compared to the levels in 2016.
Published: 2019
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32. Duke Activity Status Index cut-off scores for assessing functional capacity after stroke

Author: Luci Fuscaldi Teixeira-Salmela, Christina Danielli Coelho de Morais Faria, Silvia Lanziotti da Silva, Janaine Cunha Polese, and Iza Faria-Fortini
Subjects: 030506 rehabilitation, medicine.medical_specialty, 03 medical and health sciences, 0302 clinical medicine, Surveys and Questionnaires, Activities of Daily Living, medicine, Humans, Daily living, Binary logistic regression analysis, Stroke, Receiver operating characteristic, business.industry, Rehabilitation, Stroke Rehabilitation, Clinical reasoning, Regression analysis, medicine.disease, Cross-Sectional Studies, Activity Status, Physical therapy, Cut-off, 0305 other medical science, business, 030217 neurology & neurosurgery
Abstract: PURPOSE To determine the Duke Activity Status Index (DASI) cut-off scores and verify if they would be able to discriminate between chronic stroke individuals, who had poor, from those who had good functional capacity (FC). MATERIALS AND METHODS Cross-sectional study, where 92 individuals with chronic stroke had their FC measured by DASI scores and were classified into community and non-community walkers. Both the receiver operating characteristic and the area under the curve were used to determine the best DASI cut-off values that could discriminate between individuals, who had poor, from those who had good FC. Binary logistic regression analysis is used to investigate the ability of DASI scores in predicting community walkers. RESULTS DASI cut-off value of 31.95 showed to be sensitive and specific to differentiate between individuals, who had poor from good FC. The regression analysis revealed that the chance of individuals, who had better FC (≥ 31.95) be community walkers was 10.69 (95%CI:4-32.75) times higher than that of those who had poor FC (
Published: 2019
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33. Integrated models show a transient opportunity for sustainable management by tropical forest dwellers

Author: Lucas B. Fortini
Subjects: 0106 biological sciences, Window of opportunity, education.field_of_study, Watershed, Land use, Amazon rainforest, Natural resource economics, Forest management, Population, Tropics, Forestry, Management, Monitoring, Policy and Law, 010603 evolutionary biology, 01 natural sciences, Sustainable management, Business, education, 010606 plant biology & botany, Nature and Landscape Conservation
Abstract: Nearly 25% of world’s poor are dependent on forests, with 0.5–1 billion smallholders managing trees. This extensive human use of forests points to the need for sustainable timber management (STM) at smallholder scales. Similar to other tropical regions, households in the Amazon Estuary have harvested timber informally with minimal management for decades. This research provides a comprehensive look at the ecological and economic sustainability of forest use by local smallholders by integrating detailed plant demography, microeconomic, management and land use models at a whole watershed and community scale. In terms of conservation outcomes, resulting models show that forest management results in extensive harvests that allow for faster tree population recovery. In terms of economic outcomes, management also improves the long-term viability of the local timber industry in all scenarios considered. However, with respect to harvest regulations, given the costs of legalizing these small informal operations, legalization may indirectly lead to heavier ecological impacts as households need to harvest more to keep economic returns similar to the predominant alternative land use in the region (acai palm fruit agroforestry). Despite a fast-growing and resource-rich forest, an increasing extent of degraded forest area reduces the ecological and economic prospects for long-term management. Consequently, for this and other similar tropical forests, the viability of STM should not be evaluated as a binary and static yes or no response but instead as a moving window of opportunity that occurs when ecological, economic and policy conditions are met. Integrated model projections show that regionally-derived and ecologically-based sustainable management guidelines widen this window of opportunity by delivering the best ecological and economic outcomes under a range of scenarios considered.
Published: 2019
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34. Optical measurements based on practical methods for detecting time-wise morphing structures

Author: Michele Pinelli, Alessio Suman, Annalisa Fortini, and Elettra Fabbri
Subjects: Reverse engineering, business.product_category, Computer science, Point cloud, Kinect sensor, 02 engineering and technology, computer.software_genre, 01 natural sciences, NO, Digital image, 0202 electrical engineering, electronic engineering, information engineering, Computer vision, Electrical and Electronic Engineering, Aerospace, Instrumentation, Digital camera, Digital image analysis, Non-contact measurement, business.industry, Applied Mathematics, 020208 electrical & electronic engineering, 010401 analytical chemistry, Process (computing), Robotics, Condensed Matter Physics, 0104 chemical sciences, Optical method, Morphing, Artificial intelligence, business, computer, Digital image analysis, Kinect sensor, Non-contact measurement, Optical method, Point cloud, Reverse engineering, Instrumentation
Abstract: Nowadays non-contact measurement methods have become widely used systems in several fields especially robotics, aerospace, architecture, and cultural heritage. Practical devices, taken from mass markets, are increasingly being used in scientific and engineering research fields thanks to their ability to combine good accuracy with to the low-cost and ready-to-use experimental setup. In the present paper, digital image analysis (based on digital camera devices) and three-dimensional scanning technique (based on Kinect I and Kinect II sensors) are compared to evaluate their performance in detecting a time-wise shape modification. Digital camera and Kinect sensors are used to the non-contact detection of a morphing blade able to modify its geometry according to airflow temperature variation. The comparison showed the capability of the digital image technique to provide quantitative information when a proper alignment is adopted, while the three-dimensional scanning process allows the continuous blade detection useful to quantify the shape modification. Two-dimensional and three-dimensional blade shape reconstruction processes are also discussed.
Published: 2019
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35. The potential of indigenous agricultural food production under climate change in Hawaiʻi

Author: Tamara Ticktin, Lucas B. Fortini, and Natalie Kurashima
Subjects: Global and Planetary Change, education.field_of_study, Ecology, Renewable Energy, Sustainability and the Environment, business.industry, Natural resource economics, Geography, Planning and Development, Population, Climate change, Distribution (economics), Management, Monitoring, Policy and Law, Indigenous, Urban Studies, Geography, Agriculture, Food processing, Carrying capacity, Production (economics), education, business, Nature and Landscape Conservation, Food Science
Abstract: The value of land-use strategies that increase food production while conserving biodiversity is widely recognized. Many indigenous agroecosystems are productive, adaptive and ecologically principled, but are largely overlooked by planning in terms of their potential to meet current and future food needs. We developed spatial distribution models of indigenous agroecosystems in Hawai‘i to identify their potential past distribution, productive and carrying capacities, and future potential under current land-use and mild-to-severe future climate scenarios. Our results suggest that Hawaiʻi’s traditional agroecosystems could have had production levels comparable to consumption today. Carrying capacity estimates support hypotheses of large pre-colonial Hawaiian populations (>800,000). Urban development has reduced (−13%) traditional agroecosystems but 71% remain agriculturally zoned. Projected effects of three future climate scenarios vary from no change in potential production to decreases of 19% in the driest and warmest end-of-century scenario. This study highlights the food-producing potential of indigenous agriculture even under land-use and climate changes, and the value of their restoration into the future. Indigenous agroecosystems often balance food production with environmental concerns better than industrial approaches, but they are rarely considered for meeting modern food needs. This study uses spatial models and climate scenarios to find indigenous production in Hawaiʻi’s past could meet significant population demands then and, potentially, now, but with lower capacity in the warmest end-of-century scenario.
Published: 2019
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36. Test‐Retest Reliability of the ABILOCO Questionnaire in Individuals with Stroke

Author: Luci Fuscaldi Teixeira-Salmela, Kênia Kiefer Parreiras de Menezes, Marluce Lopes Basílio, Iza Faria-Fortini, Patrick Roberto Avelino, and Lucas R. Nascimento
Subjects: Male, 030506 rehabilitation, medicine.medical_specialty, Intraclass correlation, Physical Therapy, Sports Therapy and Rehabilitation, Severity of Illness Index, Disability Evaluation, 03 medical and health sciences, 0302 clinical medicine, Surveys and Questionnaires, Reliability study, Activities of Daily Living, medicine, Humans, Stroke, Reliability (statistics), Aged, Neurologic Examination, Rasch model, business.industry, Rehabilitation, Stroke Rehabilitation, Reproducibility of Results, Middle Aged, medicine.disease, Walking Speed, Test (assessment), Paresis, Treatment Outcome, Hemiparesis, Standard error, Neurology, Physical therapy, Female, Neurology (clinical), medicine.symptom, Gait Analysis, 0305 other medical science, business, 030217 neurology & neurosurgery
Abstract: BACKGROUND The ABILOCO is a self-reported questionnaire, specific for individuals with stroke, for the assessment of ability of locomotion. The ABILOCO has been investigated using the Rasch model and has shown satisfactory measurement properties. However, its test-retest reliability has not been investigated. OBJECTIVE To investigate the test-retest reliability, that is, agreement, systematic and random variability of the ABILOCO Questionnaire in individuals with chronic stroke. DESIGN A test-retest reliability study. SETTING Research laboratory. PARTICIPANTS Thirty-one individuals (21 men and 10 women; mean age, 60 years), who had poststroke hemiparesis. INTERVENTION Not applicable. MAIN OUTCOME MEASUREMENT The ABILOCO was applied twice, on two occasions, 5 to 7 days apart. Test-retest reliability was investigated, as follows: agreement by the calculation of intraclass correlation coefficients (ICCs); systematic variability by the change in the mean; random variability by the standard error of measurement (SEM) and smallest real difference (SRD). RESULTS Two outliers were identified in the sample. The ICC values for the whole sample were 0.76 (CI 95% 0.56 to 0.88), whereas the SEM (SEM%) and SRD (SRD%) were 0.55 (21%) and 1.52 (58%), respectively. CONCLUSION The ABILOCO showed to be reliable to be applied within clinical and research contexts for the assessment of changes in locomotion ability of a group of individuals with chronic stroke. However, it appears to be less suitable to detect changes at individual levels. LEVEL OF EVIDENCE III.
Published: 2019
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37. Autonomia e integração dos usuários transexuais em estratégia de saúde da família

Author: Denildo de Freitas Gomes, Rafael Gravina Fortini, Jaqueline da Silva Soares Souto, Marta Sauthier, Enéas Rangel Teixeira, and Donizete Vago Daher
Subjects: Invisibility, business.industry, Heteronomy, Rehabilitation, Applied psychology, RT1-120, Equity (finance), Vulnerability, Stigma (botany), Physical Therapy, Sports Therapy and Rehabilitation, Nursing, General Medicine, Transsexual, Paradigm shift, Health care, business, Psychology
Abstract: RESUMO Objetivos: identificar as publicações indexadas em banco de dados; caracterizar essas produções e analisar os resultados com apoio na teoria do reconhecimento honnetiana, oferecendo uma síntese dessas publicações. Metodologia: Revisão integrativa da literatura sistematizada, qualitativa. A questão constituiu-se em quais são as evidências sobre vulnerabilidades e integração dos usuários transexuais para seu reconhecimento nos cuidados em saúde? Recorte de 2012 a 2018 nos bancos de dados da BVS e PubMed com DECs e Mesh, respectivamente. A consulta fora realizada em 10 de agosto de 2017. Resultados: Foram encontrados 55 artigos e após utilização dos filtros, com critérios de inclusão e exclusão, restaram 25 artigos, emergindo três categorias, a saber, paradigma biomédico; estigma, invisibilidade e heteronomia; processo de trabalho. As discussões versaram sobre modelo biomédico e invisibilidade desses usuários estigmatizados, perpassando pelo processo de trabalho deficitário, por falta de conhecimentos sobre questões socioculturais de gênero e técnicas. Conclusão: A realidade descrita é inversa à integralidade da assistência que se deseja, distante da equidade pretendida, sensíveis à vulnerabilidade da população em estudo. Esses usuários, concebidos com rótulos pré-determinados, são sujeitos integrantes da comunidade em que a aceitação e convívio dependem de mudança de paradigma, em que a assistência/cuidado recebido contribua para o reconhecimento desses usuários. Descritores: Atenção primária à saúde; Transexualismo; Pessoas transgêneros.
Published: 2021
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38. Is there a serum proteome signature to predict mortality in severe COVID-19 patients?

Author: Henk W. P. van den Toorn, Francecsca Fortini, Franziska Voellmy, Savino Spadaro, Marco Contoli, Paola Rizzo, Luisa Marracino, Albert J. R. Heck, Francesco Vieceli Dalla Sega, Ottavio Zucchetti, Albetto Papi, Gianluca Campo, Riccardo Zenezini Chiozzi, and Carlo Alberto Volta
Subjects: Respiratory failure, Coronavirus disease 2019 (COVID-19), Serum proteome, business.industry, Intensive care, medicine, Physiology, Kawasaki disease, Respiratory system, Risk assessment, medicine.disease, business, Blood proteins
Abstract: Here we recorded serum proteome profiles of 33 COVID-19 patients admitted to respiratory and intensive care units because of respiratory failure. We received, for most patients, blood samples just after admission and at two more later timepoints. We focused on serum proteins different in abundance between the group of survivors and non-survivors and observed that a rather small panel of about a dozen proteins were significantly different in abundance between these two groups. The four structurally and functionally related type-3 cystatins AHSG, FETUB, HRG and KNG1 were all more abundant in the survivors. The family of inter-α-trypsin inhibitors, ITIH1, ITIH2, ITIH3 and ITIH4, were all found to be differentially abundant in between survivors and non-survivors, whereby ITIH1 and ITIH2 were more abundant in the survivor group and ITIH3 and ITIH4 more abundant in the non-survivors. ITIH1/ITIH2 and ITIH3/ITIH4 also did show opposite trends in protein abundance during disease progression. This panel of eight proteins, complemented with a few more, may represent a panel for mortality risk assessment and eventually even for treatment, by administration of exogenous proteins possibly aiding survival. Such administration is not unprecedented, as administration of exogenous inter-α-trypsin inhibitors is already used in the treatment of patients with severe sepsis and Kawasaki disease. The mortality risk panel defined here is in excellent agreement with findings in two recent COVID-19 serum proteomics studies on independent cohorts, supporting our findings. This panel may not be unique for COVID-19, as some of the proteins here annotated as mortality risk factors have previously been annotated as mortality markers in aging and in other diseases caused by different pathogens, including bacteria.
Published: 2021
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39. King's Parkinson's Disease Pain Scale (KPPS): Cross-cultural adaptation to Brazilian Portuguese and content validity

Author: Iza Faria-Fortini, Márcia Regina Coimbra, Paula Luciana Scalzo, Paulo Pereira Christo, and Camila Megale Almeida-Leite
Subjects: Cross-Cultural Comparison, Male, Parkinson's disease, Delphi method, Pain, Context (language use), Brazilian Portuguese, otorhinolaryngologic diseases, medicine, Content validity, Cross-cultural, Humans, Aged, Pain Measurement, business.industry, Reproducibility of Results, General Medicine, Pain scale, Middle Aged, medicine.disease, language.human_language, Scale (social sciences), language, Surgery, Female, Neurology (clinical), business, Brazil, Clinical psychology
Abstract: Pain is one of the most common and troublesome non-motor symptoms of Parkinson’s disease (PD). The King's Parkinson's Disease Pain Scale (KPPS) is the first scale of its kind to evaluate the burden and characterization of various phenotypes of pain in individuals with PD. The purpose of this study was to adapt the KPPS to Brazilian culture and to assess its content validity using the Delphi method. The process of adapting the original instrument to the Brazilian context occurred in six stages according to international standards. Following the pilot tests with individuals with PD, the pre-final version of the KPPS-Brazil was developed and submitted to judges to assess content validity. Three evaluation rounds were conducted, in which several corrections and changes suggested by the judges were accepted. The Content Validity Index (CVI) was calculated to determine the judges’ degree of agreement. The results demonstrated that the KPPS-Brazil showed a quite satisfactory level of semantic, idiomatic, cultural, and conceptual equivalence. The judges' opinion showed adequate content validity for all of the KPPS-Brazil items and the scale. The use of the KPPS-Brazil will enable an adequate assessment of pain in individuals with PD, contributing to clinical practice and research.
Published: 2021

40. Time course of endothelial dysfunction markers and mortality in COVID‐19 patients: A pilot study

Author: Alberto Fogagnolo, Luisa Marracino, Ottavio Zucchetti, Luca Ronzoni, Elisa Mikus, Marco Contoli, Marco Verri, Luca Morandi, Savino Spadaro, Francesca Torsani, Marco Manfrini, Emanuele D'Aniello, Francesca Fortini, Roberto Ferrari, Rita Pavasini, Carlo Alberto Volta, Gianluca Campo, Paola Rizzo, and Francesco Vieceli Dalla Sega
Subjects: 2019-20 coronavirus outbreak, Coronavirus disease 2019 (COVID-19), Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), MEDLINE, Medicine (miscellaneous), Socio-culturale, Bioinformatics, Letter to Editor, Text mining, COVID‐19, medicine, blood samples, Endothelial dysfunction, Prospective cohort study, lcsh:R5-920, endoglin, business.industry, COVID‐19, endothelial dysfunction markers, endothelin-1, endoglin, sE-selectin, thrombomodulin, soluble vascular cell adhesion molecule 1 [sVCAM-1], von Willebrand factor [vWF], blood samples, enoxaparin, enoxaparin, thrombomodulin, soluble vascular cell adhesion molecule 1 [sVCAM-1], medicine.disease, von Willebrand factor [vWF], endothelial dysfunction markers, Time course, endothelin-1, Molecular Medicine, sE-selectin, lcsh:Medicine (General), business
Published: 2021

41. Feasibility of Early Intervention Through Home-Based and Parent-Delivered Infant Massage in Infants at High Risk for Cerebral Palsy

Author: Valentina Menici, Camilla Antonelli, Elena Beani, Alessandra Mattiola, Matteo Giampietri, Giada Martini, Riccardo Rizzi, Alessandra Cecchi, Maria Luce Cioni, Giovanni Cioni, Giuseppina Sgandurra, Caretoy-R Consortium, Claudia Artese, Veronica Barzacchi, Marta Cervo, Carlo Dani, Paolo Dario, Marco Di Galante, Ugo Faraguna, Patrizio Fiorini, Viola Fortini, Simona Giustini, Clara Lunardi, Irene Mannari, Martina Maselli, Martina Orlando, Letizia Padrini, and Filomena Paternoster
Subjects: Infant massage, Pediatrics, medicine.medical_specialty, cerebral palsy, Intervention program, Massage, business.industry, early intervention, family-centered intervention, home-based intervention, infant massage, Daily diary, medicine.disease, Home based, RJ1-570, Cerebral palsy, Intervention (counseling), Pediatrics, Perinatology and Child Health, Medicine, business, Original Research
Abstract: Infant massage (IM) can be considered an early intervention program that leads to the environmental enrichment framework. The effectiveness of IM to promote neurodevelopment in preterm infants has been proved, but studies on infants with early brain damage are still lacking. The main aim of this study was to assess the feasibility, acceptability and usability of IM, carried out by parents at home, on infants at high risk for Cerebral Palsy. An IM daily diary and an ad hoc questionnaire, called Infant Massage Questionnaire Parent-Infant Experiences (IMQPE), were developed. IMQPE consisted of a total of 30 questions, divided into 5 areas. The parents were trained to carry out the IM with a home-based course, conducted by an expert therapist. The intensive IM program was set according to a defined daily length of at least 20 min, with a frequency of at least 5 days per week for a total of 8 weeks. Data collection consisted in the selection of the variables around the characteristics, both of the infants and the mothers, IM dosage and frequency, different body parts of the infants involved and IMQPE scores. Variable selection was carried out by minimizing the Bayesian Information Criteria (BIC) over all possible variable subsets. Nineteen high-risk infants, aged 4.83 ± 1.22 months, received IM at home for 8 weeks. The massage was given by the infants' mothers with a mean daily session dose of 27.79 ± 7.88 min and a total of 21.04 ± 8.49 h. 89.74% and 100% of mothers performed the IM for the minimum daily dosage and the frequency recommended, respectively. All the families filled in the IMQPE, with a Total mean score of 79.59% and of 82.22% in General Information on IM, 76.30% in Infant's intervention-related changes, 76.85% in IM Suitability, 79.07% in Infant's acceptance and 83.52% in Time required for the training. Different best predictors in mothers and in infants have been found. These data provide evidence of the feasibility of performing IM at home on infants at high risk for CP. Study registration: www.clinicaltrial.com (NCT03211533 and NCT03234959).
Published: 2021

42. HACEK Infective Endocarditis at a Tertiary Children's Hospital

Author: Jonathon McNeil and Mary B. Fortini
Subjects: Fastidious organism, Heart Defects, Congenital, Male, Adolescent, Aggregatibacter, Microbiology, Cardiobacterium, Tertiary Care Centers, 03 medical and health sciences, 0302 clinical medicine, 030225 pediatrics, Haemophilus, medicine, Endocarditis, Humans, 030212 general & internal medicine, Child, Retrospective Studies, biology, business.industry, Ceftriaxone, High-Throughput Nucleotide Sequencing, Infant, Endocarditis, Bacterial, medicine.disease, biology.organism_classification, Kingella species, HACEK endocarditis, Anti-Bacterial Agents, Infective endocarditis, Pediatrics, Perinatology and Child Health, Kingella, business
Abstract: HACEK organisms (Haemophilus, Aggregatibacter, Cardiobacterium, Eikenella, and Kingella species) are rare causes of endocarditis. HACEK organisms are fastidious and may escape detection by culture techniques, but the use of molecular studies may aid diagnosis. A 10-year review of pediatric HACEK endocarditis cases at Texas Children's Hospital identified 10 patients, with 2 cases recognized by next-generation sequencing, highlighting potential benefits of these assays.
Published: 2021

43. Spontaneous remission of West syndrome associated with acute infection and fever in five patients

Author: Alberto Espeche, Sebastian Fortini, and Roberto Caraballo
Subjects: 0301 basic medicine, Male, Pediatrics, medicine.medical_specialty, Spasm, Fever, Remission, Spontaneous, Spontaneous remission, Exanthema Subitum, 03 medical and health sciences, Epilepsy, 0302 clinical medicine, Seizures, medicine, Humans, Family history, Child, business.industry, Infant, Electroencephalography, medicine.disease, Hypsarrhythmia, Epileptic spasms, 030104 developmental biology, Neurology, Etiology, Respiratory virus, Female, Neurology (clinical), medicine.symptom, business, Spasms, Infantile, 030217 neurology & neurosurgery
Abstract: Objective We analyzed the records of 198 patients with West syndrome (WS) seen at a single pediatric neurology center in Argentina between June 2004 and June 2017. Five patients with infection-related spontaneous remission of the electroclinical manifestations were identified. Methods The following parameters were investigated: personal and family history, clinical characteristics of the seizures - mainly spasms - and EEG findings, type of treatment, and outcome. The inclusion criteria for WS were epileptic spasms (ES) in clusters, hypsarrhythmia, and mental deterioration. Infants with ES without hypsarrhythmia and other epileptic encephalopathies with ES were excluded. Results Five children, four boys and one girl, met the inclusion criteria of WS with spontaneous remission after a viral infection. The etiology of ES was unknown in four patients and one had a structural etiology. All patients had spontaneous remission of the ES and normalization of the EEG following acute upper respiratory infection in four and exanthema subitum in one; all of them had fever between 38.5 and 40 °C. Conclusion We report five patients with spontaneous remission of WS following acute viral infection, associated with a respiratory virus in four and exanthema subitum in one.
Published: 2021

44. Self-limited epilepsy of childhood with affective seizures: A well-defined epileptic syndrome?

Author: Alberto Espeche, Santiago Galicchio, Beatriz Gamboni, Lorena Fasulo, Roberto Caraballo, Sebastian Fortini, Santiago Chacon, Marcos Semprino, Pedro Cachia, Ricardo Cersósimo, and Javier Adi
Subjects: Abdominal pain, medicine.medical_specialty, Electroencephalography, Audiology, Pallor, Drooling, 03 medical and health sciences, Behavioral Neuroscience, Epilepsy, 0302 clinical medicine, Swallowing, Tongue, Seizures, Medicine, Humans, 030212 general & internal medicine, Child, Anarthria, Retrospective Studies, biology, medicine.diagnostic_test, business.industry, biology.organism_classification, medicine.disease, medicine.anatomical_structure, Neurology, Neurology (clinical), medicine.symptom, business, Epileptic Syndromes, 030217 neurology & neurosurgery
Abstract: Objective Here we present cases of focal epilepsy with affective symptoms analyzing seizure characteristics, EEG pattern, treatment, and outcome. Methods A multicenter, descriptive, retrospective study was conducted evaluating 18 patients with self-limited epilepsy who presented with seizures with affective symptoms seen between April 2000 and April 2018 at eight Argentinian centers. Results Eighteen patients had focal seizures with affective symptoms; all of them had affective symptoms characterized by sudden fright or terror and screaming. Seizures started with manifestations of sudden fright or terror manifested by a facial expression of fear; consciousness was mildly impaired in 15/18 patients. Eleven of the patients also had autonomic manifestations, such as pallor, sweating, and abdominal pain. In addition, four of these 11 patients had ictus emeticus and one also presented with unilateral deviation of the eyes and head. Speech arrest, salivation, glottal noises, and chewing or swallowing movements were observed in 2/18 patients at the onset of the affective seizures. Two others also had mild asymmetric dystonic seizures involving both hands and arms. Three patients had tonic deviation of the mouth involving the lips and tongue as well pharyngeal and laryngeal muscles, resulting in anarthria and drooling. Two patients had brief hemifacial focal clonic seizures. Conclusion Affective manifestations associated or not with motor and/or autonomic manifestations and associated with typical EEG features of the idiopathic focal epilepsies of childhood is a particular presentation of self-limited focal epilepsy in childhood.
Published: 2021

45. COVID-19 Rapid Antigen Test at hospital admission associated to the knowledge of individual risk factors allow overcoming the difficulty of managing suspected patients in hospitals COVID-19 Rapid Antigen Test facilitates the management of suspected patients on hospital admission

Author: Daniel Ap de Miranda, Camila Amormino Corsini, Rafaella Fortini Queiroz Grenfell, Priscila Vcc Reis, Lucélia Antunes Coutinho, Jéssica Vieira Da Assis, Raquel Nh Amorim, Sarah Vc Gomes, Maria Luysa C Pedrosa, Raphael A Silva, Maria Izabella Varc Medeiros, Natália Gregório Custódio, Douglas H da Silva, Priscilla Soares Filgueiras, Nathalie Bonatti Franco Almeida, Gabriel Fernandes, Cecilia Mf Bicalho, Raquel Vilela, adelina Júnia Lourenço, Gabriela Pv Santos, Alana K. de Oliveira, and Hercules P Neves
Subjects: medicine.medical_specialty, Coronavirus disease 2019 (COVID-19), business.industry, Transmission (medicine), Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), medicine.disease, Tachypnea, Test (assessment), Individual risk factors, Rapid antigen test, Emergency medicine, Medicine, medicine.symptom, business, Stroke
Abstract: Early diagnosis of SARS-CoV-2 is essential to limiting the spread of the virus and managing infected patients during hospitalization. The sensitivity of RT-qPCR is contested by the fact that it is time-consuming, executed by trained technicians in proper environment for material extraction. Here, we evaluated the first SARS-CoV-2 antigen test recommended by the World Health Organization at September, 2020 as an alternative for immediate diagnosis of symptomatic and suspected patients at a hospital in Brazil during the epidemic peak. All patients were submitted to RT-qPCR and rapid antigen test using nasopharyngeal swabs rigorously collected at the same time. Demographics, baseline comorbidities, symptoms and outcomes were considered. Prediction analysis revealed that previous stroke, chronic obstructive pulmonary disease, desaturation and tachypnea were the most relevant determinants of the death of COVID-19 patients. Comparison between the rapid antigen test and RT-qPCR revealed an overall PPV of 97%, extended to 100% when performed between 4 and 15 days of symptoms, with an accuracy of 90-91% from days 1 to 7 and a ‘Substantial’ agreement. The rapid antigen test presented no inconclusive result. Among the discordant results and RT-qPCR inconclusives, 72% presented bilateral multifocal ground-glass opacities on imaging and other exams alterations. The median time to obtain RT-qPCR results was 83.6 hours, against 15 minutes for the rapid test, precious time for deciding on patient isolation and management. Knowledge of the risk factors and a rapid diagnosis upon patient admission is critical to reduce mortality of COVID-19 patients, hospital internal costs and in-hospital transmission.
Published: 2021
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46. Clinical, cerebrospinal fluid, and neuroimaging findings in COVID-19 encephalopathy: a case series

Author: Iago N. Perissinotti, Jerusa Smid, Carlos Benatti Neto, Ida Fortini, Mariana Hiromi Manoel Oku, Bruno Fukelmann Guedes, Adalberto Studart-Neto, Ricardo Nitrini, Gabriel Taricani Kubota, Matheus Dalben Fiorentino, Tarso Adoni, Cesar Castello Branco Lopes, Luiz Henrique Martins Castro, Tomás Silva, Sara Terrim, Antonio Edvan Camelo-Filho, Maíra Medeiros Honorato Ferrari, Rafael Bernhart Carra, Julia Carvalhinho Carlos De Souza, José Pedro Soares Baima, Raphael de Luca e Tuma, Júlia Chartouni Rodrigues, Hélio Rodrigues Gomes, Bruno Diógenes Iepsen, Leandro Tavares Lucato, María M. Martín, and Márcia Rúbia Rodrigues Gonçalves
Subjects: Adult, Male, medicine.medical_specialty, Neurology, Coronavirus disease 2019 (COVID-19), medicine.medical_treatment, CNS demyelination, Encephalopathy, Clinical Neurology, Dermatology, Severity of Illness Index, Gastroenterology, Tertiary Care Centers, 03 medical and health sciences, 0302 clinical medicine, Cerebrospinal fluid, Neuroimaging, Internal medicine, Severity of illness, medicine, Humans, In patient, 030212 general & internal medicine, Hospital Mortality, Dialysis, Neuroradiology, Aged, Retrospective Studies, Aged, 80 and over, Mechanical ventilation, Brain Diseases, business.industry, COVID-19, Retrospective cohort study, General Medicine, Middle Aged, medicine.disease, Magnetic Resonance Imaging, Critical care, Psychiatry and Mental health, Female, Neurology (clinical), Neurosurgery, business, 030217 neurology & neurosurgery
Abstract: ObjectiveTo describe the clinical, neurological, neuroimaging and cerebrospinal fluid (CSF) findings associated with encephalopathy in patients admitted to a COVID-19 tertiary reference center.MethodsWe retrospectively reviewed records of consecutive patients with COVID-19 evaluated by a consulting neurology team from March 30, 2020 through May 15, 2020.ResultsFifty-five patients with confirmed SARS-CoV-2 were included, 43 of whom showed encephalopathy, and were further divided into mild, moderate and severe encephalopathy groups. Nineteen patients (44%) had undergone mechanical ventilation and received intravenous sedatives. Eleven (26%) patients were on dialysis. Laboratory markers of COVID-19 severity were very common in encephalopathy patients, but did not correlate with the severity of encephalopathy. Thirty-nine patients underwent neuroimaging studies, which showed mostly non-specific changes. One patient showed lesions possibly related to CNS demyelination. Four had suffered an acute stroke. SARS-CoV-2 was detected by RT-PCR in only one of 21 CSF samples. Two CSF samples showed elevated white blood cell count and all were negative for oligoclonal bands. In our case series the severity of encephalopathy correlated with higher probability of death during hospitalization (OR = 5.5 for each increment in the degree of encephalopathy, from absent (0) to mild (1), moderate (2) or severe (3), pConclusionIn our consecutive series with 43 encephalopathy cases, neuroimaging and CSF analysis did not support the role of direct viral CNS invasion or CNS inflammation as the cause of encephalopathy.
Published: 2021
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47. Incidence of deep vein thrombosis through an ultrasound surveillance protocol in patients with COVID-19 pneumonia in non-ICU setting: A multicenter prospective study

Author: Fabio Luise, Lucia Sammicheli, Irene Tassinari, Filippo Pieralli, Andrea Ungar, Chiara Beltrame, Riccardo Pini, Rossella Marcucci, Alessandro Milia, Francesca Innocenti, Margherita Giampieri, Alberto Fortini, Fulvio Pomero, Francesca Caldi, Antonio Mancini, Domenico Prisco, and Antonio Faraone
Subjects: Male, Viral Diseases, Pulmonology, Epidemiology, Deep vein, 030204 cardiovascular system & hematology, Fondaparinux, Vascular Medicine, Diagnostic Radiology, 0302 clinical medicine, Medical Conditions, Ultrasound Imaging, Medicine and Health Sciences, 030212 general & internal medicine, Prospective cohort study, Ultrasonography, Aged, 80 and over, Venous Thrombosis, Multidisciplinary, Incidence (epidemiology), Incidence, Radiology and Imaging, Anticoagulant, Venous Thromboembolism, Middle Aged, Thrombosis, Hospitals, Deep Vein Thrombosis, Intensive Care Units, medicine.anatomical_structure, Infectious Diseases, Lower Extremity, Anesthesia, Medicine, Female, medicine.symptom, Aged, Anticoagulants, COVID-19, Enoxaparin, Humans, Anatomy, medicine.drug, Research Article, medicine.drug_class, Imaging Techniques, Science, Research and Analysis Methods, Asymptomatic, 03 medical and health sciences, Diagnostic Medicine, Thromboembolism, medicine, cardiovascular diseases, business.industry, Biology and Life Sciences, Covid 19, Pneumonia, medicine.disease, Health Care, Health Care Facilities, Medical Risk Factors, Body Limbs, business
Abstract: Objective The aim of this study was to assess the incidence of deep vein thrombosis (DVT) of the lower limbs, using serial compression ultrasound (CUS) surveillance, in acutely ill patients with COVID-19 pneumonia admitted to a non-ICU setting. Methods Multicenter, prospective study of patients with COVID-19 pneumonia admitted to Internal Medicine units. All patients were screened for DVT of the lower limbs with serial CUS. Anticoagulation was defined as: low dose (enoxaparin 20–40 mg/day or fondaparinux 1.5–2.5 mg/day); intermediate dose (enoxaparin 60–80 mg/day); high dose (enoxaparin 120–160 mg or fondaparinux 5–10 mg/day or oral anticoagulation). The primary end-point of the study was the diagnosis of DVT by CUS. Results Over a two-month period, 227 consecutive patients with moderate-severe COVID-19 pneumonia were enrolled. The incidence of DVT was 13.7% (6.2% proximal, 7.5% distal), mostly asymptomatic. All patients received anticoagulation (enoxaparin 95.6%) at the following doses: low 57.3%, intermediate 22.9%, high 19.8%. Patients with and without DVT had similar characteristics, and no difference in anticoagulant regimen was observed. DVT patients were older (mean 77±9.6 vs 71±13.1 years; p = 0.042) and had higher peak D-dimer levels (5403 vs 1723 ng/mL; p = 0.004). At ROC analysis peak D-dimer level >2000 ng/mL (AUC 0.703; 95% CI 0.572–0.834; p = 0.004) was the most accurate cut-off value able to predict DVT (RR 3.74; 95%CI 1.27–10, p = 0.016). Conclusions The incidence of DVT in acutely ill patients with COVID-19 pneumonia is relevant. A surveillance protocol by serial CUS of the lower limbs is useful to timely identify DVT that would go otherwise largely undetected.
Published: 2021

48. Diagnostic potential of antigen test as a screening method for SARS-CoV-2 compared to RT-qPCR in swab samples at Hospital da Baleia, Belo Horizonte/MG

Author: Daniel Alvim Pena de Miranda, Sarah Vieira Contin Gomes, Camila Amormino Corsini, Nathalie Bonatti Franco Almeida, adelina Júnia Lourenço, Priscilla Soares Filgueiras, and Rafaella Fortini Grenfell e Queiroz
Subjects: business.industry, Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), Screening method, Medicine, business, Antigen test, Virology
Published: 2021
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49. Blood Interferon-α Levels and Severity, Outcomes, and Inflammatory Profiles in Hospitalized COVID-19 Patients

Author: Marco Contoli, Alberto Papi, Luca Tomassetti, Paola Rizzo, Francesco Vieceli Dalla Sega, Francesca Fortini, Francesca Torsani, Luca Morandi, Luca Ronzoni, Ottavio Zucchetti, Rita Pavasini, Alberto Fogagnolo, Carlo Alberto Volta, Nathan W. Bartlett, Sebastian L. Johnston, Savino Spadaro, and Gianluca Campo
Subjects: lcsh:Immunologic diseases. Allergy, 0301 basic medicine, Male, medicine.medical_specialty, Immunology, Alpha interferon, Socio-culturale, Severity of Illness Index, COVID−19, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, Severity of illness, medicine, SARS–CoV−2, Immunology and Allergy, Humans, COVID−19, SARS–CoV−2, interferon, mortality, respiratory failure, 030212 general & internal medicine, Prospective Studies, Prospective cohort study, Interferon alfa, Original Research, Aged, business.industry, SARS-CoV-2, Case-control study, respiratory failure, COVID-19, Interferon-alpha, interferon, Middle Aged, Prognosis, mortality, Hospitalization, 030104 developmental biology, Respiratory failure, Case-Control Studies, Cohort, Host-Pathogen Interactions, Population study, Female, Inflammation Mediators, lcsh:RC581-607, business, Biomarkers, medicine.drug
Abstract: Background: Deficient interferon responses have been proposed as one of the relevant mechanisms prompting severe manifestations of COVID-19.Objective: To evaluate the interferon (IFN)-α levels in a cohort of COVID-19 patients in relation to severity, evolution of the clinical manifestations and immune/inflammatory profile.Methods: This is prospective study recruiting consecutive hospitalized patients with respiratory failure associated with SARS-COV-2 infection and matched controls. After enrollment, patients were assessed every 7 ± 2 days for additional 2 consecutive visits, for a total of 21 days. The severity of the clinical condition was ranked based on the level of respiratory support required. At each time-point blood samples were obtained to assess immune cells and mediators by multiplex immunoassay.Results: Fifty-four COVD-19 and 11 control patients matched for severity were enrolled. At recruitment, lower levels of blood IFN-α were found in COVID-19 patients compared to controls (3.8-fold difference, p < 0.01). Improvements in COVID-19 severity were paralleled by a significant increase of blood IFN-α levels. A significant increase in blood IFN-α was found over the study period in survivors (70% of the study population). A similar trend was found for blood IFN-β with IFN-β levels below the threshold of detectability in a substantial proportion of subjects. Significantly higher values of blood lymphocytes and lower levels of IL-10 were found at each time point in patients who survived compared to patients who died. In patients who clinically improved and survived during the study, we found an inverse association between IL-10 and IFN-α levels.Conclusion: The study identifies a blood immune profile defined by deficient IFN-α levels associated with increased IL-10 expression in patients progressing to severe/life threatening COVID-19 conditions, suggesting the involvement of immunological pathways that could be target of pharmacological intervention.Clinical Trial Registration:ClinicalTrials.gov identifier NCT04343053.
Published: 2021

50. Adding a 'Notch' to Cardiovascular Disease Therapeutics: A MicroRNA-Based Approach

Author: Luisa Marracino, Francesca Fortini, Esmaa Bouhamida, Francesca Camponogara, Paolo Severi, Elisa Mazzoni, Simone Patergnani, Emanuele D’Aniello, Roberta Campana, Paolo Pinton, Fernanda Martini, Mauro Tognon, Gianluca Campo, Roberto Ferrari, Francesco Vieceli Dalla Sega, and Paola Rizzo
Subjects: Myocardial ischemia, Notch, QH301-705.5, business.industry, ischemia-reperfusion injury, Notch signaling pathway, heart failure, Review, Cell Biology, Disease, Bioinformatics, NO, Cell and Developmental Biology, myocardial ischemia, calcific aortic valve disease, microRNA, Gene expression, Medicine, Biology (General), Notch, miRNA, atherosclerosis, arrhytmia, heart failure, myocardial ischemia, ischemia-reperfusion injury, calcific aortic valve disease, atherosclerosis, business, Developmental Biology, miRNA, arrhytmia
Abstract: Dysregulation of the Notch pathway is implicated in the pathophysiology of cardiovascular diseases (CVDs), but, as of today, therapies based on the re-establishing the physiological levels of Notch in the heart and vessels are not available. A possible reason is the context-dependent role of Notch in the cardiovascular system, which would require a finely tuned, cell-specific approach. MicroRNAs (miRNAs) are short functional endogenous, non-coding RNA sequences able to regulate gene expression at post-transcriptional levels influencing most, if not all, biological processes. Dysregulation of miRNAs expression is implicated in the molecular mechanisms underlying many CVDs. Notch is regulated and regulates a large number of miRNAs expressed in the cardiovascular system and, thus, targeting these miRNAs could represent an avenue to be explored to target Notch for CVDs. In this Review, we provide an overview of both established and potential, based on evidence in other pathologies, crosstalks between miRNAs and Notch in cellular processes underlying atherosclerosis, myocardial ischemia, heart failure, calcification of aortic valve, and arrhythmias. We also discuss the potential advantages, as well as the challenges, of using miRNAs for a Notch-based approach for the diagnosis and treatment of the most common CVDs.
Published: 2021

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