1. Evaluation of the Prognosis of Neuroglioma Based on Dynamic Magnetic Resonance Enhancement
- Author
-
Naiwu Wang, Fengjia Li, Chunyu Song, Xingtao Diao, Hui Zhang, Yue Zhang, and Yong Gao
- Subjects
Male ,Oncology ,medicine.medical_specialty ,Multivariate analysis ,medicine.medical_treatment ,Contrast Media ,Brain Edema ,Kaplan-Meier Estimate ,Neurosurgical Procedures ,03 medical and health sciences ,0302 clinical medicine ,Internal medicine ,Glioma ,Temozolomide ,medicine ,Humans ,Karnofsky Performance Status ,Antineoplastic Agents, Alkylating ,Survival analysis ,Proportional Hazards Models ,Epilepsy ,medicine.diagnostic_test ,Brain Neoplasms ,business.industry ,Proportional hazards model ,Headache ,Magnetic resonance imaging ,Middle Aged ,Prognosis ,medicine.disease ,Magnetic Resonance Imaging ,Tumor Burden ,Radiation therapy ,Ki-67 Antigen ,Chemotherapy, Adjuvant ,030220 oncology & carcinogenesis ,Preoperative Period ,Female ,Radiotherapy, Adjuvant ,Surgery ,Neurology (clinical) ,Neurosurgery ,Neoplasm Grading ,business ,030217 neurology & neurosurgery ,medicine.drug - Abstract
This paper explores the diagnostic value of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) for the prognosis of glioma, and judges the relevant factors affecting the prognosis of glioma. This paper used a Cox proportional hazards model to retrospectively analyze clinical data of 81 patients with complete neuroglioma from the same neurosurgery medical team from January 2012 to November 2018, including DCE-MRI data. To determine the prognostic factors, P < 0.05 was used as the statistical standard, and the survival curve of statistically significant factors was drawn by Kaplan-Meier method. The Cox proportional hazard model analysis showed the preoperative Karnofsky Performance Status Scale (KPS) score, age, tumor pathologic grade, postoperative radiotherapy, temozolomide use, and Ki-67 expression had an impact on the prognosis of patients with neuroglioma. Multivariate analysis and DCE-MRI data showed that age, tumor grade, preoperative KPS score, postoperative radiotherapy, and Ki-67 expression were prognostic factors for patients with glioma. The older the age, the higher the pathologic grade, the higher the Ki-67 expression level, and the lower the KPS score before surgery, the worse the prognosis. Postoperative radiotherapy and appropriate temozolomide chemotherapy will help improve the prognosis of patients with neuroglioma.
- Published
- 2020